                         SEQUENCE LISTING

<110>  Scribe Therapeutics Inc.
 
<120>  AAV VECTORS FOR GENE EDITING

<130>  SCRB-028/02WO 333322-2131

<150>  US 63/235,638
<151>  2021-08-20

<150>  US 63/123,112
<151>  2020-12-09

<160>  41847 

<170>  PatentIn version 3.5

<210>  1
<211>  986
<212>  PRT
<213>  Unknown

<220>
<223>  Deltaproteobacteria sp.

<400>  1

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Asn Ala Ala Asn Asn 
    50                  55                  60                  


Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala Ile Leu 
65                  70                  75                  80  


Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu Met Cys 
                85                  90                  95      


Lys Phe Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys 
            100                 105                 110         


Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser 
    130                 135                 140                 


Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala 
145                 150                 155                 160 


Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp 
                165                 170                 175     


Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu Arg 
                325                 330                 335     


Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys Lys 
            340                 345                 350         


Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly Val 
        355                 360                 365             


Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu Pro 
    370                 375                 380                 


Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro Lys 
385                 390                 395                 400 


Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu Lys 
                405                 410                 415     


Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu Arg 
            420                 425                 430         


Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu Glu 
        435                 440                 445             


Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp Trp 
    450                 455                 460                 


Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met Asp 
465                 470                 475                 480 


Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr Gly 
                485                 490                 495     


Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Arg Val Val 
            500                 505                 510         


Asp Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr 
        515                 520                 525             


Arg Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe 
    530                 535                 540                 


Tyr Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp 
545                 550                 555                 560 


Gly Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly 
                565                 570                 575     


Gly Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu 
            580                 585                 590         


Gln Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu 
        595                 600                 605             


Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu 
    610                 615                 620                 


Ala Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly 
625                 630                 635                 640 


Arg Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu 
                645                 650                 655     


Val Val Asp Pro Ser Asn Ile Lys Pro Val Asn Leu Ile Gly Val Asp 
            660                 665                 670         


Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly 
        675                 680                 685             


Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro Thr Asp Ile 
    690                 695                 700                 


Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala Ile Gln Ala 
705                 710                 715                 720 


Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Phe 
                725                 730                 735     


Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg Asn Ser Ala 
            740                 745                 750         


Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val Leu Val Phe 
        755                 760                 765             


Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met 
    770                 775                 780                 


Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr Ala Lys Leu 
785                 790                 795                 800 


Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala 
                805                 810                 815     


Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Thr 
            820                 825                 830         


Ala Asp Tyr Asp Gly Met Leu Val Arg Leu Lys Lys Thr Ser Asp Gly 
        835                 840                 845             


Trp Ala Thr Thr Leu Asn Asn Lys Glu Leu Lys Ala Glu Gly Gln Ile 
    850                 855                 860                 


Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Thr Val Glu Lys Glu Leu Ser 
865                 870                 875                 880 


Ala Glu Leu Asp Arg Leu Ser Glu Glu Ser Gly Asn Asn Asp Ile Ser 
                885                 890                 895     


Lys Trp Thr Lys Gly Arg Arg Asp Glu Ala Leu Phe Leu Leu Lys Lys 
            900                 905                 910         


Arg Phe Ser His Arg Pro Val Gln Glu Gln Phe Val Cys Leu Asp Cys 
        915                 920                 925             


Gly His Glu Val His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg 
    930                 935                 940                 


Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser Tyr Lys 
945                 950                 955                 960 


Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr Lys Arg 
                965                 970                 975     


Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
            980                 985     


<210>  2
<211>  978
<212>  PRT
<213>  Unknown

<220>
<223>  Planctomycetes sp.

<400>  2

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3
<211>  855
<212>  PRT
<213>  Unknown

<220>
<223>  Candidatus Sungbacteria sp.

<400>  3

Met Asp Asn Ala Asn Lys Pro Ser Thr Lys Ser Leu Val Asn Thr Thr 
1               5                   10                  15      


Arg Ile Ser Asp His Phe Gly Val Thr Pro Gly Gln Val Thr Arg Val 
            20                  25                  30          


Phe Ser Phe Gly Ile Ile Pro Thr Lys Arg Gln Tyr Ala Ile Ile Glu 
        35                  40                  45              


Arg Trp Phe Ala Ala Val Glu Ala Ala Arg Glu Arg Leu Tyr Gly Met 
    50                  55                  60                  


Leu Tyr Ala His Phe Gln Glu Asn Pro Pro Ala Tyr Leu Lys Glu Lys 
65                  70                  75                  80  


Phe Ser Tyr Glu Thr Phe Phe Lys Gly Arg Pro Val Leu Asn Gly Leu 
                85                  90                  95      


Arg Asp Ile Asp Pro Thr Ile Met Thr Ser Ala Val Phe Thr Ala Leu 
            100                 105                 110         


Arg His Lys Ala Glu Gly Ala Met Ala Ala Phe His Thr Asn His Arg 
        115                 120                 125             


Arg Leu Phe Glu Glu Ala Arg Lys Lys Met Arg Glu Tyr Ala Glu Cys 
    130                 135                 140                 


Leu Lys Ala Asn Glu Ala Leu Leu Arg Gly Ala Ala Asp Ile Asp Trp 
145                 150                 155                 160 


Asp Lys Ile Val Asn Ala Leu Arg Thr Arg Leu Asn Thr Cys Leu Ala 
                165                 170                 175     


Pro Glu Tyr Asp Ala Val Ile Ala Asp Phe Gly Ala Leu Cys Ala Phe 
            180                 185                 190         


Arg Ala Leu Ile Ala Glu Thr Asn Ala Leu Lys Gly Ala Tyr Asn His 
        195                 200                 205             


Ala Leu Asn Gln Met Leu Pro Ala Leu Val Lys Val Asp Glu Pro Glu 
    210                 215                 220                 


Glu Ala Glu Glu Ser Pro Arg Leu Arg Phe Phe Asn Gly Arg Ile Asn 
225                 230                 235                 240 


Asp Leu Pro Lys Phe Pro Val Ala Glu Arg Glu Thr Pro Pro Asp Thr 
                245                 250                 255     


Glu Thr Ile Ile Arg Gln Leu Glu Asp Met Ala Arg Val Ile Pro Asp 
            260                 265                 270         


Thr Ala Glu Ile Leu Gly Tyr Ile His Arg Ile Arg His Lys Ala Ala 
        275                 280                 285             


Arg Arg Lys Pro Gly Ser Ala Val Pro Leu Pro Gln Arg Val Ala Leu 
    290                 295                 300                 


Tyr Cys Ala Ile Arg Met Glu Arg Asn Pro Glu Glu Asp Pro Ser Thr 
305                 310                 315                 320 


Val Ala Gly His Phe Leu Gly Glu Ile Asp Arg Val Cys Glu Lys Arg 
                325                 330                 335     


Arg Gln Gly Leu Val Arg Thr Pro Phe Asp Ser Gln Ile Arg Ala Arg 
            340                 345                 350         


Tyr Met Asp Ile Ile Ser Phe Arg Ala Thr Leu Ala His Pro Asp Arg 
        355                 360                 365             


Trp Thr Glu Ile Gln Phe Leu Arg Ser Asn Ala Ala Ser Arg Arg Val 
    370                 375                 380                 


Arg Ala Glu Thr Ile Ser Ala Pro Phe Glu Gly Phe Ser Trp Thr Ser 
385                 390                 395                 400 


Asn Arg Thr Asn Pro Ala Pro Gln Tyr Gly Met Ala Leu Ala Lys Asp 
                405                 410                 415     


Ala Asn Ala Pro Ala Asp Ala Pro Glu Leu Cys Ile Cys Leu Ser Pro 
            420                 425                 430         


Ser Ser Ala Ala Phe Ser Val Arg Glu Lys Gly Gly Asp Leu Ile Tyr 
        435                 440                 445             


Met Arg Pro Thr Gly Gly Arg Arg Gly Lys Asp Asn Pro Gly Lys Glu 
    450                 455                 460                 


Ile Thr Trp Val Pro Gly Ser Phe Asp Glu Tyr Pro Ala Ser Gly Val 
465                 470                 475                 480 


Ala Leu Lys Leu Arg Leu Tyr Phe Gly Arg Ser Gln Ala Arg Arg Met 
                485                 490                 495     


Leu Thr Asn Lys Thr Trp Gly Leu Leu Ser Asp Asn Pro Arg Val Phe 
            500                 505                 510         


Ala Ala Asn Ala Glu Leu Val Gly Lys Lys Arg Asn Pro Gln Asp Arg 
        515                 520                 525             


Trp Lys Leu Phe Phe His Met Val Ile Ser Gly Pro Pro Pro Val Glu 
    530                 535                 540                 


Tyr Leu Asp Phe Ser Ser Asp Val Arg Ser Arg Ala Arg Thr Val Ile 
545                 550                 555                 560 


Gly Ile Asn Arg Gly Glu Val Asn Pro Leu Ala Tyr Ala Val Val Ser 
                565                 570                 575     


Val Glu Asp Gly Gln Val Leu Glu Glu Gly Leu Leu Gly Lys Lys Glu 
            580                 585                 590         


Tyr Ile Asp Gln Leu Ile Glu Thr Arg Arg Arg Ile Ser Glu Tyr Gln 
        595                 600                 605             


Ser Arg Glu Gln Thr Pro Pro Arg Asp Leu Arg Gln Arg Val Arg His 
    610                 615                 620                 


Leu Gln Asp Thr Val Leu Gly Ser Ala Arg Ala Lys Ile His Ser Leu 
625                 630                 635                 640 


Ile Ala Phe Trp Lys Gly Ile Leu Ala Ile Glu Arg Leu Asp Asp Gln 
                645                 650                 655     


Phe His Gly Arg Glu Gln Lys Ile Ile Pro Lys Lys Thr Tyr Leu Ala 
            660                 665                 670         


Asn Lys Thr Gly Phe Met Asn Ala Leu Ser Phe Ser Gly Ala Val Arg 
        675                 680                 685             


Val Asp Lys Lys Gly Asn Pro Trp Gly Gly Met Ile Glu Ile Tyr Pro 
    690                 695                 700                 


Gly Gly Ile Ser Arg Thr Cys Thr Gln Cys Gly Thr Val Trp Leu Ala 
705                 710                 715                 720 


Arg Arg Pro Lys Asn Pro Gly His Arg Asp Ala Met Val Val Ile Pro 
                725                 730                 735     


Asp Ile Val Asp Asp Ala Ala Ala Thr Gly Phe Asp Asn Val Asp Cys 
            740                 745                 750         


Asp Ala Gly Thr Val Asp Tyr Gly Glu Leu Phe Thr Leu Ser Arg Glu 
        755                 760                 765             


Trp Val Arg Leu Thr Pro Arg Tyr Ser Arg Val Met Arg Gly Thr Leu 
    770                 775                 780                 


Gly Asp Leu Glu Arg Ala Ile Arg Gln Gly Asp Asp Arg Lys Ser Arg 
785                 790                 795                 800 


Gln Met Leu Glu Leu Ala Leu Glu Pro Gln Pro Gln Trp Gly Gln Phe 
                805                 810                 815     


Phe Cys His Arg Cys Gly Phe Asn Gly Gln Ser Asp Val Leu Ala Ala 
            820                 825                 830         


Thr Asn Leu Ala Arg Arg Ala Ile Ser Leu Ile Arg Arg Leu Pro Asp 
        835                 840                 845             


Thr Asp Thr Pro Pro Thr Pro 
    850                 855 


<210>  4
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  4
acaucuggcg cguuuauucc auuacuuugg agccaguccc agcgacuaug ucguauggac       60

gaagcgcuua uuuaucggag agaaaccgau aaguaaaacg caucaaag                   108


<210>  5
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  5
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  6
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  6
acaucuggcg cguuuauucc auuacuuugg agccaguccc agcgacuaug ucguauggac       60

gaagcgcuua uuuaucggag a                                                 81


<210>  7
<211>  78
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  7
acaucuggcg cguuuauucc auuacuuugg agccaguccc agcgacuaug ucguauggac       60

gaagcgcuua uuuaucgg                                                     78


<210>  8
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  8
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga                                                   80


<210>  9
<211>  77
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  9
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgg                                                      77


<210>  10
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  10
guuuacacac ucccucucau agggu                                             25


<210>  11
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  11
guuuacacac ucccucucau gaggu                                             25


<210>  12
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  12
uuuuacauac ccccucucau gggau                                             25


<210>  13
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  13
guuuacacac ucccucucau ggggg                                             25


<210>  14
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  14
ccagcgacua ugucguaugg                                                   20


<210>  15
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  15
gcgcuuauuu aucggagaga aauccgauaa auaagaagc                              39


<210>  16
<211>  74
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA sequence

<400>  16
ggcgcuuuua ucucauuacu uugagagcca ucaccagcga cuaugucgua uggguaaagc       60

gcuuauuuau cgga                                                         74


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E6 primer sequence

<400>  17
tgtggtcggg gtagcggctg                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E7 primer sequence

<400>  18
tcaagtccgc catgcccgaa                                                   20


<210>  19
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  stem loop sequence


<220>
<221>  misc_feature
<222>  (4)..(18)
<223>  n is any ribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(18)
<223>  individual ribonucleotides may be absent

<400>  19
uuunnnnnnn nnnnnnnnuu u                                                 21


<210>  20
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold stem loop

<400>  20
ccagcgacua ugucguaugg                                                   20


<210>  21
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA extended stem loop

<400>  21
gcgcuuauuu aucggagaga aauccgauaa auaagaagc                              39


<210>  22
<211>  81
<212>  RNA
<213>  Unknown

<220>
<223>  Deltaproteobacteria spp.

<400>  22
acaucuggcg cguuuauucc auuacuuugg agccaguccc agcgacuaug ucguauggac       60

gaagcgcuua uuuaucggag a                                                 81


<210>  23
<211>  78
<212>  RNA
<213>  Unknown

<220>
<223>  Deltaproteobacteria spp.

<400>  23
acaucuggcg cguuuauucc auuacuuugg agccaguccc agcgacuaug ucguauggac       60

gaagcgcuua uuuaucgg                                                     78


<210>  24
<211>  23
<212>  RNA
<213>  Unknown

<220>
<223>  Deltaproteobacteria spp.

<400>  24
ccgauaagua aaacgcauca aag                                               23


<210>  25
<211>  80
<212>  RNA
<213>  Unknown

<220>
<223>  Planctomycetes spp.

<400>  25
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga                                                   80


<210>  26
<211>  77
<212>  RNA
<213>  Unknown

<220>
<223>  Planctomycetes spp.

<400>  26
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgg                                                      77


<210>  27
<211>  26
<212>  RNA
<213>  Unknown

<220>
<223>  Planctomycetes spp.

<400>  27
ucuccgauaa auaagaagca ucaaag                                            26


<210>  28
<211>  25
<212>  RNA
<213>  Unknown

<220>
<223>  Candidatus Sungbacteria sp.

<400>  28
guuuacacac ucccucucau agggu                                             25


<210>  29
<211>  25
<212>  RNA
<213>  Unknown

<220>
<223>  Candidatus Sungbacteria sp.

<400>  29
guuuacacac ucccucucau gaggu                                             25


<210>  30
<211>  25
<212>  RNA
<213>  Unknown

<220>
<223>  Candidatus Sungbacteria sp.

<400>  30
uuuuacauac ccccucucau gggau                                             25


<210>  31
<211>  25
<212>  RNA
<213>  Unknown

<220>
<223>  Candidatus Sungbacteria sp.

<400>  31
guuuacacac ucccucucau ggggg                                             25


<210>  32
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold stem loop

<400>  32
ccagcgacua ugucguagug g                                                 21


<210>  33
<211>  3142
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser 
1               5                   10                  15      


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
        35                  40                  45              


Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln 
    50                  55                  60                  


Pro Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Val 
65                  70                  75                  80  


Ala Glu Glu Pro Leu His Arg Pro Lys Lys Glu Leu Ser Ala Thr Lys 
                85                  90                  95      


Lys Asp Arg Val Asn His Cys Leu Thr Ile Cys Glu Asn Ile Val Ala 
            100                 105                 110         


Gln Ser Val Arg Asn Ser Pro Glu Phe Gln Lys Leu Leu Gly Ile Ala 
        115                 120                 125             


Met Glu Leu Phe Leu Leu Cys Ser Asp Asp Ala Glu Ser Asp Val Arg 
    130                 135                 140                 


Met Val Ala Asp Glu Cys Leu Asn Lys Val Ile Lys Ala Leu Met Asp 
145                 150                 155                 160 


Ser Asn Leu Pro Arg Leu Gln Leu Glu Leu Tyr Lys Glu Ile Lys Lys 
                165                 170                 175     


Asn Gly Ala Pro Arg Ser Leu Arg Ala Ala Leu Trp Arg Phe Ala Glu 
            180                 185                 190         


Leu Ala His Leu Val Arg Pro Gln Lys Cys Arg Pro Tyr Leu Val Asn 
        195                 200                 205             


Leu Leu Pro Cys Leu Thr Arg Thr Ser Lys Arg Pro Glu Glu Ser Val 
    210                 215                 220                 


Gln Glu Thr Leu Ala Ala Ala Val Pro Lys Ile Met Ala Ser Phe Gly 
225                 230                 235                 240 


Asn Phe Ala Asn Asp Asn Glu Ile Lys Val Leu Leu Lys Ala Phe Ile 
                245                 250                 255     


Ala Asn Leu Lys Ser Ser Ser Pro Thr Ile Arg Arg Thr Ala Ala Gly 
            260                 265                 270         


Ser Ala Val Ser Ile Cys Gln His Ser Arg Arg Thr Gln Tyr Phe Tyr 
        275                 280                 285             


Ser Trp Leu Leu Asn Val Leu Leu Gly Leu Leu Val Pro Val Glu Asp 
    290                 295                 300                 


Glu His Ser Thr Leu Leu Ile Leu Gly Val Leu Leu Thr Leu Arg Tyr 
305                 310                 315                 320 


Leu Val Pro Leu Leu Gln Gln Gln Val Lys Asp Thr Ser Leu Lys Gly 
                325                 330                 335     


Ser Phe Gly Val Thr Arg Lys Glu Met Glu Val Ser Pro Ser Ala Glu 
            340                 345                 350         


Gln Leu Val Gln Val Tyr Glu Leu Thr Leu His His Thr Gln His Gln 
        355                 360                 365             


Asp His Asn Val Val Thr Gly Ala Leu Glu Leu Leu Gln Gln Leu Phe 
    370                 375                 380                 


Arg Thr Pro Pro Pro Glu Leu Leu Gln Thr Leu Thr Ala Val Gly Gly 
385                 390                 395                 400 


Ile Gly Gln Leu Thr Ala Ala Lys Glu Glu Ser Gly Gly Arg Ser Arg 
                405                 410                 415     


Ser Gly Ser Ile Val Glu Leu Ile Ala Gly Gly Gly Ser Ser Cys Ser 
            420                 425                 430         


Pro Val Leu Ser Arg Lys Gln Lys Gly Lys Val Leu Leu Gly Glu Glu 
        435                 440                 445             


Glu Ala Leu Glu Asp Asp Ser Glu Ser Arg Ser Asp Val Ser Ser Ser 
    450                 455                 460                 


Ala Leu Thr Ala Ser Val Lys Asp Glu Ile Ser Gly Glu Leu Ala Ala 
465                 470                 475                 480 


Ser Ser Gly Val Ser Thr Pro Gly Ser Ala Gly His Asp Ile Ile Thr 
                485                 490                 495     


Glu Gln Pro Arg Ser Gln His Thr Leu Gln Ala Asp Ser Val Asp Leu 
            500                 505                 510         


Ala Ser Cys Asp Leu Thr Ser Ser Ala Thr Asp Gly Asp Glu Glu Asp 
        515                 520                 525             


Ile Leu Ser His Ser Ser Ser Gln Val Ser Ala Val Pro Ser Asp Pro 
    530                 535                 540                 


Ala Met Asp Leu Asn Asp Gly Thr Gln Ala Ser Ser Pro Ile Ser Asp 
545                 550                 555                 560 


Ser Ser Gln Thr Thr Thr Glu Gly Pro Asp Ser Ala Val Thr Pro Ser 
                565                 570                 575     


Asp Ser Ser Glu Ile Val Leu Asp Gly Thr Asp Asn Gln Tyr Leu Gly 
            580                 585                 590         


Leu Gln Ile Gly Gln Pro Gln Asp Glu Asp Glu Glu Ala Thr Gly Ile 
        595                 600                 605             


Leu Pro Asp Glu Ala Ser Glu Ala Phe Arg Asn Ser Ser Met Ala Leu 
    610                 615                 620                 


Gln Gln Ala His Leu Leu Lys Asn Met Ser His Cys Arg Gln Pro Ser 
625                 630                 635                 640 


Asp Ser Ser Val Asp Lys Phe Val Leu Arg Asp Glu Ala Thr Glu Pro 
                645                 650                 655     


Gly Asp Gln Glu Asn Lys Pro Cys Arg Ile Lys Gly Asp Ile Gly Gln 
            660                 665                 670         


Ser Thr Asp Asp Asp Ser Ala Pro Leu Val His Cys Val Arg Leu Leu 
        675                 680                 685             


Ser Ala Ser Phe Leu Leu Thr Gly Gly Lys Asn Val Leu Val Pro Asp 
    690                 695                 700                 


Arg Asp Val Arg Val Ser Val Lys Ala Leu Ala Leu Ser Cys Val Gly 
705                 710                 715                 720 


Ala Ala Val Ala Leu His Pro Glu Ser Phe Phe Ser Lys Leu Tyr Lys 
                725                 730                 735     


Val Pro Leu Asp Thr Thr Glu Tyr Pro Glu Glu Gln Tyr Val Ser Asp 
            740                 745                 750         


Ile Leu Asn Tyr Ile Asp His Gly Asp Pro Gln Val Arg Gly Ala Thr 
        755                 760                 765             


Ala Ile Leu Cys Gly Thr Leu Ile Cys Ser Ile Leu Ser Arg Ser Arg 
    770                 775                 780                 


Phe His Val Gly Asp Trp Met Gly Thr Ile Arg Thr Leu Thr Gly Asn 
785                 790                 795                 800 


Thr Phe Ser Leu Ala Asp Cys Ile Pro Leu Leu Arg Lys Thr Leu Lys 
                805                 810                 815     


Asp Glu Ser Ser Val Thr Cys Lys Leu Ala Cys Thr Ala Val Arg Asn 
            820                 825                 830         


Cys Val Met Ser Leu Cys Ser Ser Ser Tyr Ser Glu Leu Gly Leu Gln 
        835                 840                 845             


Leu Ile Ile Asp Val Leu Thr Leu Arg Asn Ser Ser Tyr Trp Leu Val 
    850                 855                 860                 


Arg Thr Glu Leu Leu Glu Thr Leu Ala Glu Ile Asp Phe Arg Leu Val 
865                 870                 875                 880 


Ser Phe Leu Glu Ala Lys Ala Glu Asn Leu His Arg Gly Ala His His 
                885                 890                 895     


Tyr Thr Gly Leu Leu Lys Leu Gln Glu Arg Val Leu Asn Asn Val Val 
            900                 905                 910         


Ile His Leu Leu Gly Asp Glu Asp Pro Arg Val Arg His Val Ala Ala 
        915                 920                 925             


Ala Ser Leu Ile Arg Leu Val Pro Lys Leu Phe Tyr Lys Cys Asp Gln 
    930                 935                 940                 


Gly Gln Ala Asp Pro Val Val Ala Val Ala Arg Asp Gln Ser Ser Val 
945                 950                 955                 960 


Tyr Leu Lys Leu Leu Met His Glu Thr Gln Pro Pro Ser His Phe Ser 
                965                 970                 975     


Val Ser Thr Ile Thr Arg Ile Tyr Arg Gly Tyr Asn Leu Leu Pro Ser 
            980                 985                 990         


Ile Thr Asp Val Thr Met Glu Asn  Asn Leu Ser Arg Val  Ile Ala Ala 
        995                 1000                 1005             


Val Ser  His Glu Leu Ile Thr  Ser Thr Thr Arg Ala  Leu Thr Phe 
    1010                 1015                 1020             


Gly Cys  Cys Glu Ala Leu Cys  Leu Leu Ser Thr Ala  Phe Pro Val 
    1025                 1030                 1035             


Cys Ile  Trp Ser Leu Gly Trp  His Cys Gly Val Pro  Pro Leu Ser 
    1040                 1045                 1050             


Ala Ser  Asp Glu Ser Arg Lys  Ser Cys Thr Val Gly  Met Ala Thr 
    1055                 1060                 1065             


Met Ile  Leu Thr Leu Leu Ser  Ser Ala Trp Phe Pro  Leu Asp Leu 
    1070                 1075                 1080             


Ser Ala  His Gln Asp Ala Leu  Ile Leu Ala Gly Asn  Leu Leu Ala 
    1085                 1090                 1095             


Ala Ser  Ala Pro Lys Ser Leu  Arg Ser Ser Trp Ala  Ser Glu Glu 
    1100                 1105                 1110             


Glu Ala  Asn Pro Ala Ala Thr  Lys Gln Glu Glu Val  Trp Pro Ala 
    1115                 1120                 1125             


Leu Gly  Asp Arg Ala Leu Val  Pro Met Val Glu Gln  Leu Phe Ser 
    1130                 1135                 1140             


His Leu  Leu Lys Val Ile Asn  Ile Cys Ala His Val  Leu Asp Asp 
    1145                 1150                 1155             


Val Ala  Pro Gly Pro Ala Ile  Lys Ala Ala Leu Pro  Ser Leu Thr 
    1160                 1165                 1170             


Asn Pro  Pro Ser Leu Ser Pro  Ile Arg Arg Lys Gly  Lys Glu Lys 
    1175                 1180                 1185             


Glu Pro  Gly Glu Gln Ala Ser  Val Pro Leu Ser Pro  Lys Lys Gly 
    1190                 1195                 1200             


Ser Glu  Ala Ser Ala Ala Ser  Arg Gln Ser Asp Thr  Ser Gly Pro 
    1205                 1210                 1215             


Val Thr  Thr Ser Lys Ser Ser  Ser Leu Gly Ser Phe  Tyr His Leu 
    1220                 1225                 1230             


Pro Ser  Tyr Leu Lys Leu His  Asp Val Leu Lys Ala  Thr His Ala 
    1235                 1240                 1245             


Asn Tyr  Lys Val Thr Leu Asp  Leu Gln Asn Ser Thr  Glu Lys Phe 
    1250                 1255                 1260             


Gly Gly  Phe Leu Arg Ser Ala  Leu Asp Val Leu Ser  Gln Ile Leu 
    1265                 1270                 1275             


Glu Leu  Ala Thr Leu Gln Asp  Ile Gly Lys Cys Val  Glu Glu Ile 
    1280                 1285                 1290             


Leu Gly  Tyr Leu Lys Ser Cys  Phe Ser Arg Glu Pro  Met Met Ala 
    1295                 1300                 1305             


Thr Val  Cys Val Gln Gln Leu  Leu Lys Thr Leu Phe  Gly Thr Asn 
    1310                 1315                 1320             


Leu Ala  Ser Gln Phe Asp Gly  Leu Ser Ser Asn Pro  Ser Lys Ser 
    1325                 1330                 1335             


Gln Gly  Arg Ala Gln Arg Leu  Gly Ser Ser Ser Val  Arg Pro Gly 
    1340                 1345                 1350             


Leu Tyr  His Tyr Cys Phe Met  Ala Pro Tyr Thr His  Phe Thr Gln 
    1355                 1360                 1365             


Ala Leu  Ala Asp Ala Ser Leu  Arg Asn Met Val Gln  Ala Glu Gln 
    1370                 1375                 1380             


Glu Asn  Asp Thr Ser Gly Trp  Phe Asp Val Leu Gln  Lys Val Ser 
    1385                 1390                 1395             


Thr Gln  Leu Lys Thr Asn Leu  Thr Ser Val Thr Lys  Asn Arg Ala 
    1400                 1405                 1410             


Asp Lys  Asn Ala Ile His Asn  His Ile Arg Leu Phe  Glu Pro Leu 
    1415                 1420                 1425             


Val Ile  Lys Ala Leu Lys Gln  Tyr Thr Thr Thr Thr  Cys Val Gln 
    1430                 1435                 1440             


Leu Gln  Lys Gln Val Leu Asp  Leu Leu Ala Gln Leu  Val Gln Leu 
    1445                 1450                 1455             


Arg Val  Asn Tyr Cys Leu Leu  Asp Ser Asp Gln Val  Phe Ile Gly 
    1460                 1465                 1470             


Phe Val  Leu Lys Gln Phe Glu  Tyr Ile Glu Val Gly  Gln Phe Arg 
    1475                 1480                 1485             


Glu Ser  Glu Ala Ile Ile Pro  Asn Ile Phe Phe Phe  Leu Val Leu 
    1490                 1495                 1500             


Leu Ser  Tyr Glu Arg Tyr His  Ser Lys Gln Ile Ile  Gly Ile Pro 
    1505                 1510                 1515             


Lys Ile  Ile Gln Leu Cys Asp  Gly Ile Met Ala Ser  Gly Arg Lys 
    1520                 1525                 1530             


Ala Val  Thr His Ala Ile Pro  Ala Leu Gln Pro Ile  Val His Asp 
    1535                 1540                 1545             


Leu Phe  Val Leu Arg Gly Thr  Asn Lys Ala Asp Ala  Gly Lys Glu 
    1550                 1555                 1560             


Leu Glu  Thr Gln Lys Glu Val  Val Val Ser Met Leu  Leu Arg Leu 
    1565                 1570                 1575             


Ile Gln  Tyr His Gln Val Leu  Glu Met Phe Ile Leu  Val Leu Gln 
    1580                 1585                 1590             


Gln Cys  His Lys Glu Asn Glu  Asp Lys Trp Lys Arg  Leu Ser Arg 
    1595                 1600                 1605             


Gln Ile  Ala Asp Ile Ile Leu  Pro Met Leu Ala Lys  Gln Gln Met 
    1610                 1615                 1620             


His Ile  Asp Ser His Glu Ala  Leu Gly Val Leu Asn  Thr Leu Phe 
    1625                 1630                 1635             


Glu Ile  Leu Ala Pro Ser Ser  Leu Arg Pro Val Asp  Met Leu Leu 
    1640                 1645                 1650             


Arg Ser  Met Phe Val Thr Pro  Asn Thr Met Ala Ser  Val Ser Thr 
    1655                 1660                 1665             


Val Gln  Leu Trp Ile Ser Gly  Ile Leu Ala Ile Leu  Arg Val Leu 
    1670                 1675                 1680             


Ile Ser  Gln Ser Thr Glu Asp  Ile Val Leu Ser Arg  Ile Gln Glu 
    1685                 1690                 1695             


Leu Ser  Phe Ser Pro Tyr Leu  Ile Ser Cys Thr Val  Ile Asn Arg 
    1700                 1705                 1710             


Leu Arg  Asp Gly Asp Ser Thr  Ser Thr Leu Glu Glu  His Ser Glu 
    1715                 1720                 1725             


Gly Lys  Gln Ile Lys Asn Leu  Pro Glu Glu Thr Phe  Ser Arg Phe 
    1730                 1735                 1740             


Leu Leu  Gln Leu Val Gly Ile  Leu Leu Glu Asp Ile  Val Thr Lys 
    1745                 1750                 1755             


Gln Leu  Lys Val Glu Met Ser  Glu Gln Gln His Thr  Phe Tyr Cys 
    1760                 1765                 1770             


Gln Glu  Leu Gly Thr Leu Leu  Met Cys Leu Ile His  Ile Phe Lys 
    1775                 1780                 1785             


Ser Gly  Met Phe Arg Arg Ile  Thr Ala Ala Ala Thr  Arg Leu Phe 
    1790                 1795                 1800             


Arg Ser  Asp Gly Cys Gly Gly  Ser Phe Tyr Thr Leu  Asp Ser Leu 
    1805                 1810                 1815             


Asn Leu  Arg Ala Arg Ser Met  Ile Thr Thr His Pro  Ala Leu Val 
    1820                 1825                 1830             


Leu Leu  Trp Cys Gln Ile Leu  Leu Leu Val Asn His  Thr Asp Tyr 
    1835                 1840                 1845             


Arg Trp  Trp Ala Glu Val Gln  Gln Thr Pro Lys Arg  His Ser Leu 
    1850                 1855                 1860             


Ser Ser  Thr Lys Leu Leu Ser  Pro Gln Met Ser Gly  Glu Glu Glu 
    1865                 1870                 1875             


Asp Ser  Asp Leu Ala Ala Lys  Leu Gly Met Cys Asn  Arg Glu Ile 
    1880                 1885                 1890             


Val Arg  Arg Gly Ala Leu Ile  Leu Phe Cys Asp Tyr  Val Cys Gln 
    1895                 1900                 1905             


Asn Leu  His Asp Ser Glu His  Leu Thr Trp Leu Ile  Val Asn His 
    1910                 1915                 1920             


Ile Gln  Asp Leu Ile Ser Leu  Ser His Glu Pro Pro  Val Gln Asp 
    1925                 1930                 1935             


Phe Ile  Ser Ala Val His Arg  Asn Ser Ala Ala Ser  Gly Leu Phe 
    1940                 1945                 1950             


Ile Gln  Ala Ile Gln Ser Arg  Cys Glu Asn Leu Ser  Thr Pro Thr 
    1955                 1960                 1965             


Met Leu  Lys Lys Thr Leu Gln  Cys Leu Glu Gly Ile  His Leu Ser 
    1970                 1975                 1980             


Gln Ser  Gly Ala Val Leu Thr  Leu Tyr Val Asp Arg  Leu Leu Cys 
    1985                 1990                 1995             


Thr Pro  Phe Arg Val Leu Ala  Arg Met Val Asp Ile  Leu Ala Cys 
    2000                 2005                 2010             


Arg Arg  Val Glu Met Leu Leu  Ala Ala Asn Leu Gln  Ser Ser Met 
    2015                 2020                 2025             


Ala Gln  Leu Pro Met Glu Glu  Leu Asn Arg Ile Gln  Glu Tyr Leu 
    2030                 2035                 2040             


Gln Ser  Ser Gly Leu Ala Gln  Arg His Gln Arg Leu  Tyr Ser Leu 
    2045                 2050                 2055             


Leu Asp  Arg Phe Arg Leu Ser  Thr Met Gln Asp Ser  Leu Ser Pro 
    2060                 2065                 2070             


Ser Pro  Pro Val Ser Ser His  Pro Leu Asp Gly Asp  Gly His Val 
    2075                 2080                 2085             


Ser Leu  Glu Thr Val Ser Pro  Asp Lys Asp Trp Tyr  Val His Leu 
    2090                 2095                 2100             


Val Lys  Ser Gln Cys Trp Thr  Arg Ser Asp Ser Ala  Leu Leu Glu 
    2105                 2110                 2115             


Gly Ala  Glu Leu Val Asn Arg  Ile Pro Ala Glu Asp  Met Asn Ala 
    2120                 2125                 2130             


Phe Met  Met Asn Ser Glu Phe  Asn Leu Ser Leu Leu  Ala Pro Cys 
    2135                 2140                 2145             


Leu Ser  Leu Gly Met Ser Glu  Ile Ser Gly Gly Gln  Lys Ser Ala 
    2150                 2155                 2160             


Leu Phe  Glu Ala Ala Arg Glu  Val Thr Leu Ala Arg  Val Ser Gly 
    2165                 2170                 2175             


Thr Val  Gln Gln Leu Pro Ala  Val His His Val Phe  Gln Pro Glu 
    2180                 2185                 2190             


Leu Pro  Ala Glu Pro Ala Ala  Tyr Trp Ser Lys Leu  Asn Asp Leu 
    2195                 2200                 2205             


Phe Gly  Asp Ala Ala Leu Tyr  Gln Ser Leu Pro Thr  Leu Ala Arg 
    2210                 2215                 2220             


Ala Leu  Ala Gln Tyr Leu Val  Val Val Ser Lys Leu  Pro Ser His 
    2225                 2230                 2235             


Leu His  Leu Pro Pro Glu Lys  Glu Lys Asp Ile Val  Lys Phe Val 
    2240                 2245                 2250             


Val Ala  Thr Leu Glu Ala Leu  Ser Trp His Leu Ile  His Glu Gln 
    2255                 2260                 2265             


Ile Pro  Leu Ser Leu Asp Leu  Gln Ala Gly Leu Asp  Cys Cys Cys 
    2270                 2275                 2280             


Leu Ala  Leu Gln Leu Pro Gly  Leu Trp Ser Val Val  Ser Ser Thr 
    2285                 2290                 2295             


Glu Phe  Val Thr His Ala Cys  Ser Leu Ile Tyr Cys  Val His Phe 
    2300                 2305                 2310             


Ile Leu  Glu Ala Val Ala Val  Gln Pro Gly Glu Gln  Leu Leu Ser 
    2315                 2320                 2325             


Pro Glu  Arg Arg Thr Asn Thr  Pro Lys Ala Ile Ser  Glu Glu Glu 
    2330                 2335                 2340             


Glu Glu  Val Asp Pro Asn Thr  Gln Asn Pro Lys Tyr  Ile Thr Ala 
    2345                 2350                 2355             


Ala Cys  Glu Met Val Ala Glu  Met Val Glu Ser Leu  Gln Ser Val 
    2360                 2365                 2370             


Leu Ala  Leu Gly His Lys Arg  Asn Ser Gly Val Pro  Ala Phe Leu 
    2375                 2380                 2385             


Thr Pro  Leu Leu Arg Asn Ile  Ile Ile Ser Leu Ala  Arg Leu Pro 
    2390                 2395                 2400             


Leu Val  Asn Ser Tyr Thr Arg  Val Pro Pro Leu Val  Trp Lys Leu 
    2405                 2410                 2415             


Gly Trp  Ser Pro Lys Pro Gly  Gly Asp Phe Gly Thr  Ala Phe Pro 
    2420                 2425                 2430             


Glu Ile  Pro Val Glu Phe Leu  Gln Glu Lys Glu Val  Phe Lys Glu 
    2435                 2440                 2445             


Phe Ile  Tyr Arg Ile Asn Thr  Leu Gly Trp Thr Ser  Arg Thr Gln 
    2450                 2455                 2460             


Phe Glu  Glu Thr Trp Ala Thr  Leu Leu Gly Val Leu  Val Thr Gln 
    2465                 2470                 2475             


Pro Leu  Val Met Glu Gln Glu  Glu Ser Pro Pro Glu  Glu Asp Thr 
    2480                 2485                 2490             


Glu Arg  Thr Gln Ile Asn Val  Leu Ala Val Gln Ala  Ile Thr Ser 
    2495                 2500                 2505             


Leu Val  Leu Ser Ala Met Thr  Val Pro Val Ala Gly  Asn Pro Ala 
    2510                 2515                 2520             


Val Ser  Cys Leu Glu Gln Gln  Pro Arg Asn Lys Pro  Leu Lys Ala 
    2525                 2530                 2535             


Leu Asp  Thr Arg Phe Gly Arg  Lys Leu Ser Ile Ile  Arg Gly Ile 
    2540                 2545                 2550             


Val Glu  Gln Glu Ile Gln Ala  Met Val Ser Lys Arg  Glu Asn Ile 
    2555                 2560                 2565             


Ala Thr  His His Leu Tyr Gln  Ala Trp Asp Pro Val  Pro Ser Leu 
    2570                 2575                 2580             


Ser Pro  Ala Thr Thr Gly Ala  Leu Ile Ser His Glu  Lys Leu Leu 
    2585                 2590                 2595             


Leu Gln  Ile Asn Pro Glu Arg  Glu Leu Gly Ser Met  Ser Tyr Lys 
    2600                 2605                 2610             


Leu Gly  Gln Val Ser Ile His  Ser Val Trp Leu Gly  Asn Ser Ile 
    2615                 2620                 2625             


Thr Pro  Leu Arg Glu Glu Glu  Trp Asp Glu Glu Glu  Glu Glu Glu 
    2630                 2635                 2640             


Ala Asp  Ala Pro Ala Pro Ser  Ser Pro Pro Thr Ser  Pro Val Asn 
    2645                 2650                 2655             


Ser Arg  Lys His Arg Ala Gly  Val Asp Ile His Ser  Cys Ser Gln 
    2660                 2665                 2670             


Phe Leu  Leu Glu Leu Tyr Ser  Arg Trp Ile Leu Pro  Ser Ser Ser 
    2675                 2680                 2685             


Ala Arg  Arg Thr Pro Ala Ile  Leu Ile Ser Glu Val  Val Arg Ser 
    2690                 2695                 2700             


Leu Leu  Val Val Ser Asp Leu  Phe Thr Glu Arg Asn  Gln Phe Glu 
    2705                 2710                 2715             


Leu Met  Tyr Val Thr Leu Thr  Glu Leu Arg Arg Val  His Pro Ser 
    2720                 2725                 2730             


Glu Asp  Glu Ile Leu Ala Gln  Tyr Leu Val Pro Ala  Thr Cys Lys 
    2735                 2740                 2745             


Ala Ala  Ala Val Leu Gly Met  Asp Lys Ala Val Ala  Glu Pro Val 
    2750                 2755                 2760             


Ser Arg  Leu Leu Glu Ser Thr  Leu Arg Ser Ser His  Leu Pro Ser 
    2765                 2770                 2775             


Arg Val  Gly Ala Leu His Gly  Val Leu Tyr Val Leu  Glu Cys Asp 
    2780                 2785                 2790             


Leu Leu  Asp Asp Thr Ala Lys  Gln Leu Ile Pro Val  Ile Ser Asp 
    2795                 2800                 2805             


Tyr Leu  Leu Ser Asn Leu Lys  Gly Ile Ala His Cys  Val Asn Ile 
    2810                 2815                 2820             


His Ser  Gln Gln His Val Leu  Val Met Cys Ala Thr  Ala Phe Tyr 
    2825                 2830                 2835             


Leu Ile  Glu Asn Tyr Pro Leu  Asp Val Gly Pro Glu  Phe Ser Ala 
    2840                 2845                 2850             


Ser Ile  Ile Gln Met Cys Gly  Val Met Leu Ser Gly  Ser Glu Glu 
    2855                 2860                 2865             


Ser Thr  Pro Ser Ile Ile Tyr  His Cys Ala Leu Arg  Gly Leu Glu 
    2870                 2875                 2880             


Arg Leu  Leu Leu Ser Glu Gln  Leu Ser Arg Leu Asp  Ala Glu Ser 
    2885                 2890                 2895             


Leu Val  Lys Leu Ser Val Asp  Arg Val Asn Val His  Ser Pro His 
    2900                 2905                 2910             


Arg Ala  Met Ala Ala Leu Gly  Leu Met Leu Thr Cys  Met Tyr Thr 
    2915                 2920                 2925             


Gly Lys  Glu Lys Val Ser Pro  Gly Arg Thr Ser Asp  Pro Asn Pro 
    2930                 2935                 2940             


Ala Ala  Pro Asp Ser Glu Ser  Val Ile Val Ala Met  Glu Arg Val 
    2945                 2950                 2955             


Ser Val  Leu Phe Asp Arg Ile  Arg Lys Gly Phe Pro  Cys Glu Ala 
    2960                 2965                 2970             


Arg Val  Val Ala Arg Ile Leu  Pro Gln Phe Leu Asp  Asp Phe Phe 
    2975                 2980                 2985             


Pro Pro  Gln Asp Ile Met Asn  Lys Val Ile Gly Glu  Phe Leu Ser 
    2990                 2995                 3000             


Asn Gln  Gln Pro Tyr Pro Gln  Phe Met Ala Thr Val  Val Tyr Lys 
    3005                 3010                 3015             


Val Phe  Gln Thr Leu His Ser  Thr Gly Gln Ser Ser  Met Val Arg 
    3020                 3025                 3030             


Asp Trp  Val Met Leu Ser Leu  Ser Asn Phe Thr Gln  Arg Ala Pro 
    3035                 3040                 3045             


Val Ala  Met Ala Thr Trp Ser  Leu Ser Cys Phe Phe  Val Ser Ala 
    3050                 3055                 3060             


Ser Thr  Ser Pro Trp Val Ala  Ala Ile Leu Pro His  Val Ile Ser 
    3065                 3070                 3075             


Arg Met  Gly Lys Leu Glu Gln  Val Asp Val Asn Leu  Phe Cys Leu 
    3080                 3085                 3090             


Val Ala  Thr Asp Phe Tyr Arg  His Gln Ile Glu Glu  Glu Leu Asp 
    3095                 3100                 3105             


Arg Arg  Ala Phe Gln Ser Val  Leu Glu Val Val Ala  Ala Pro Gly 
    3110                 3115                 3120             


Ser Pro  Tyr His Arg Leu Leu  Thr Cys Leu Arg Asn  Val His Lys 
    3125                 3130                 3135             


Val Thr  Thr Cys 
    3140         


<210>  34
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA stem loop


<220>
<221>  misc_feature
<222>  (4)..(28)
<223>  n is any ribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(28)
<223>  individual ribonucleotides may be absent

<400>  34
uuunnnnnnn nnnnnnnnnn nnnnnnnnuu u                                      31


<210>  35
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MS2 stem loop

<400>  35
acaugaggau cacccaugu                                                    19


<210>  36
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Qbeta stem loop

<400>  36
ugcaugucua agacagca                                                     18


<210>  37
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  U1 hairpin II stem loop

<400>  37
aauccauugc acuccggauu                                                   20


<210>  38
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Uvsx stem loop

<400>  38
ccucuucgga gg                                                           12


<210>  39
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PP7 stem loop

<400>  39
aggaguuucu auggaaaccc u                                                 21


<210>  40
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  phage replication loop

<400>  40
aggugggacg accucucggu cguccuaucu                                        30


<210>  41
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  kissing loop a

<400>  41
ugcucgcucc guucgagca                                                    19


<210>  42
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  kissing loop b1

<400>  42
ugcucgacgc guccucgagc a                                                 21


<210>  43
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  kissing loop b2

<400>  43
ugcucguuug cggcuacgag ca                                                22


<210>  44
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  G quadriplex M3q

<400>  44
agggagggag ggagagg                                                      17


<210>  45
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  G quadriplex telomere basket

<400>  45
gguuaggguu aggguuagg                                                    19


<210>  46
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Sarcin-ricin loop

<400>  46
cugcucagua cgagaggaac cgcag                                             25


<210>  47
<211>  78
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  pseudoknots

<400>  47
uacacuggga ucgcugaauu agagaucggc guccuuucau ucuauauacu uuggaguuuu       60

aaaaugucuc uaaguaca                                                     78


<210>  48
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXXC zing finger/ribbon domain


<220>
<221>  SITE
<222>  (2)..(3)
<223>  Xaa is any amino acid

<400>  48

Cys Xaa Xaa Cys 
1               


<210>  49
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  49

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  50
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  50

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Thr Ala Asp Tyr Asp Gly Met Leu Val Arg Leu Lys Lys Thr Ser 
            820                 825                 830         


Asp Gly Trp Ala Thr Thr Leu Asn Asn Lys Glu Leu Lys Ala Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Thr Val Glu Lys Glu 
    850                 855                 860                 


Leu Ser Ala Glu Leu Asp Arg Leu Ser Glu Glu Ser Gly Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Lys Trp Thr Lys Gly Arg Arg Asp Glu Ala Leu Phe Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Gln Phe Val Cys Leu 
            900                 905                 910         


Asp Cys Gly His Glu Val His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  51
<211>  985
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  51

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Asn Ala Ala Asn Asn 
    50                  55                  60                  


Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala Ile Leu 
65                  70                  75                  80  


Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu Met Cys 
                85                  90                  95      


Lys Phe Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile 
            100                 105                 110         


Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn 
    130                 135                 140                 


Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser 
145                 150                 155                 160 


Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn 
                165                 170                 175     


Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu 
            180                 185                 190         


Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys 
        195                 200                 205             


Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly 
    210                 215                 220                 


Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser 
225                 230                 235                 240 


Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn 
                245                 250                 255     


Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu 
            260                 265                 270         


Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly 
        275                 280                 285             


Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn 
    290                 295                 300                 


Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro 
305                 310                 315                 320 


Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu Arg Arg 
                325                 330                 335     


Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys Lys Leu 
            340                 345                 350         


Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly Val Thr 
        355                 360                 365             


Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu Pro Asn 
    370                 375                 380                 


Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro Lys Lys 
385                 390                 395                 400 


Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu Lys Lys 
                405                 410                 415     


Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu Arg Ile 
            420                 425                 430         


Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu Glu Ala 
        435                 440                 445             


Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp Trp Leu 
    450                 455                 460                 


Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met Asp Glu 
465                 470                 475                 480 


Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr Gly Asp 
                485                 490                 495     


Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Arg Val Val Asp 
            500                 505                 510         


Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr Arg 
        515                 520                 525             


Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe Tyr 
    530                 535                 540                 


Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp Gly 
545                 550                 555                 560 


Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly Gly 
                565                 570                 575     


Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu Gln 
            580                 585                 590         


Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu Phe 
        595                 600                 605             


Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu Ala 
    610                 615                 620                 


Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly Arg 
625                 630                 635                 640 


Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val 
                645                 650                 655     


Val Asp Pro Ser Asn Ile Lys Pro Val Asn Leu Ile Gly Val Asp Arg 
            660                 665                 670         


Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys 
        675                 680                 685             


Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro Thr Asp Ile Leu 
    690                 695                 700                 


Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala Ile Gln Ala Ala 
705                 710                 715                 720 


Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Phe Ala 
                725                 730                 735     


Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg Asn Ser Ala Arg 
            740                 745                 750         


Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val Leu Val Phe Glu 
        755                 760                 765             


Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Thr 
    770                 775                 780                 


Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr Ala Lys Leu Ala 
785                 790                 795                 800 


Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln 
                805                 810                 815     


Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Thr Ala 
            820                 825                 830         


Asp Tyr Asp Gly Met Leu Val Arg Leu Lys Lys Thr Ser Asp Gly Trp 
        835                 840                 845             


Ala Thr Thr Leu Asn Asn Lys Glu Leu Lys Ala Glu Gly Gln Ile Thr 
    850                 855                 860                 


Tyr Tyr Asn Arg Tyr Lys Arg Gln Thr Val Glu Lys Glu Leu Ser Ala 
865                 870                 875                 880 


Glu Leu Asp Arg Leu Ser Glu Glu Ser Gly Asn Asn Asp Ile Ser Lys 
                885                 890                 895     


Trp Thr Lys Gly Arg Arg Asp Glu Ala Leu Phe Leu Leu Lys Lys Arg 
            900                 905                 910         


Phe Ser His Arg Pro Val Gln Glu Gln Phe Val Cys Leu Asp Cys Gly 
        915                 920                 925             


His Glu Val His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser 
    930                 935                 940                 


Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser Tyr Lys Ser 
945                 950                 955                 960 


Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr Lys Arg Arg 
                965                 970                 975     


Leu Lys Glu Val Trp Lys Pro Asn Ala 
            980                 985 


<210>  52
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  52

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Asn Ala Ala Asn Asn 
    50                  55                  60                  


Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala Ile Leu 
65                  70                  75                  80  


Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu Met Cys 
                85                  90                  95      


Lys Phe Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys 
            100                 105                 110         


Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser 
    130                 135                 140                 


Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala 
145                 150                 155                 160 


Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp 
                165                 170                 175     


Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu Arg 
                325                 330                 335     


Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys Lys 
            340                 345                 350         


Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly Val 
        355                 360                 365             


Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu Pro 
    370                 375                 380                 


Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro Lys 
385                 390                 395                 400 


Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu Lys 
                405                 410                 415     


Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu Arg 
            420                 425                 430         


Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu Glu 
        435                 440                 445             


Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp Trp 
    450                 455                 460                 


Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met Asp 
465                 470                 475                 480 


Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr Gly 
                485                 490                 495     


Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Arg Val Val 
            500                 505                 510         


Asp Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr 
        515                 520                 525             


Arg Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe 
    530                 535                 540                 


Tyr Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp 
545                 550                 555                 560 


Gly Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly 
                565                 570                 575     


Gly Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu 
            580                 585                 590         


Gln Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu 
        595                 600                 605             


Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu 
    610                 615                 620                 


Ala Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly 
625                 630                 635                 640 


Arg Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu 
                645                 650                 655     


Val Val Asp Pro Ser Asn Ile Lys Pro Val Asn Leu Ile Gly Val Asp 
            660                 665                 670         


Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly 
        675                 680                 685             


Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro Thr Asp Ile 
    690                 695                 700                 


Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala Ile Gln Ala 
705                 710                 715                 720 


Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Phe 
                725                 730                 735     


Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg Asn Ser Ala 
            740                 745                 750         


Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val Leu Val Phe 
        755                 760                 765             


Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met 
    770                 775                 780                 


Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr Ala Lys Leu 
785                 790                 795                 800 


Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala 
                805                 810                 815     


Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser 
            820                 825                 830         


Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly 
        835                 840                 845             


Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile 
    850                 855                 860                 


Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser 
865                 870                 875                 880 


Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser 
                885                 890                 895     


Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys 
            900                 905                 910         


Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys 
        915                 920                 925             


Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg 
    930                 935                 940                 


Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser Tyr Lys 
945                 950                 955                 960 


Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr Lys Arg 
                965                 970                 975     


Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
            980                 985     


<210>  53
<211>  921
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  53

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Val Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro 
        675                 680                 685             


Thr Asp Ile Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Phe Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Ser Ala Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val 
            740                 745                 750         


Leu Val Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala 
        915                 920     


<210>  54
<211>  920
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  54

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala 
        915                 920 


<210>  55
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  55

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Asn Ala Ala 
    50                  55                  60                  


Asn Asn Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala 
65                  70                  75                  80  


Ile Leu Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu 
                85                  90                  95      


Met Cys Lys Phe Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  56
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  56

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu 
                325                 330                 335     


Arg Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys 
            340                 345                 350         


Lys Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly 
        355                 360                 365             


Val Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu 
    370                 375                 380                 


Pro Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro 
385                 390                 395                 400 


Lys Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu 
                405                 410                 415     


Lys Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu 
            420                 425                 430         


Arg Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu 
        435                 440                 445             


Glu Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp 
    450                 455                 460                 


Trp Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met 
465                 470                 475                 480 


Asp Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr 
                485                 490                 495     


Gly Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Ser Ile 
            500                 505                 510         


Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile Trp 
        515                 520                 525             


Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn Tyr 
    530                 535                 540                 


Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala Phe 
545                 550                 555                 560 


Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu Ile 
                565                 570                 575     


Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile Ile 
            580                 585                 590         


Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp Asn 
        595                 600                 605             


Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly Arg 
    610                 615                 620                 


Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu Pro 
625                 630                 635                 640 


Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp Ser 
                645                 650                 655     


Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn 
            660                 665                 670         


Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser 
        675                 680                 685             


Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly 
    690                 695                 700                 


Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val 
705                 710                 715                 720 


Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala 
                725                 730                 735     


Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu 
            740                 745                 750         


Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser 
        755                 760                 765             


Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln 
    770                 775                 780                 


Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly 
785                 790                 795                 800 


Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys 
                805                 810                 815     


Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg 
            820                 825                 830         


Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile 
        835                 840                 845             


Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg 
    850                 855                 860                 


Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg 
865                 870                 875                 880 


Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly 
                885                 890                 895     


Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg 
            900                 905                 910         


Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His 
        915                 920                 925             


Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu 
    930                 935                 940                 


Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn 
945                 950                 955                 960 


Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys 
                965                 970                 975     


Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
            980                 985     


<210>  57
<211>  925
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  57

Met Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu Leu Thr Asp 
1               5                   10                  15      


Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp Glu Glu Phe 
            20                  25                  30          


Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln Pro Ala Pro 
        35                  40                  45              


Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp Gly Asn Glu 
    50                  55                  60                  


Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys Gln Pro Leu 
65                  70                  75                  80  


Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys Pro His Thr 
                85                  90                  95      


Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg Leu Ile Leu 
            100                 105                 110         


Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val Thr Tyr Ser 
        115                 120                 125             


Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser Ile His Val 
    130                 135                 140                 


Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu Gln Ile Gly Gly 
145                 150                 155                 160 


Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu Ser Asp Ala Cys 
                165                 170                 175     


Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu 
            180                 185                 190         


Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu 
        195                 200                 205             


Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu 
    210                 215                 220                 


Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val 
225                 230                 235                 240 


Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu Trp Gln Lys Leu 
                245                 250                 255     


Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe 
            260                 265                 270         


Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val Asp Trp Trp 
        275                 280                 285             


Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp 
    290                 295                 300                 


Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala 
305                 310                 315                 320 


Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys 
                325                 330                 335     


Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His Leu Glu Lys Lys 
            340                 345                 350         


His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile 
        355                 360                 365             


Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu Glu Glu Glu 
    370                 375                 380                 


Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu 
385                 390                 395                 400 


Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu Ala Asp Lys 
                405                 410                 415     


Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp 
            420                 425                 430         


Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Arg Val Val Asp 
        435                 440                 445             


Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr Arg 
    450                 455                 460                 


Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe Tyr 
465                 470                 475                 480 


Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp Gly 
                485                 490                 495     


Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly Gly 
            500                 505                 510         


Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu Gln 
        515                 520                 525             


Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu Phe 
    530                 535                 540                 


Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu Ala 
545                 550                 555                 560 


Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly Arg 
                565                 570                 575     


Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val 
            580                 585                 590         


Val Asp Pro Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg 
        595                 600                 605             


Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys 
    610                 615                 620                 


Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu 
625                 630                 635                 640 


Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys 
                645                 650                 655     


Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala 
            660                 665                 670         


Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg 
        675                 680                 685             


Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu 
    690                 695                 700                 


Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala 
705                 710                 715                 720 


Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala 
                725                 730                 735     


Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr 
            740                 745                 750         


Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp 
        755                 760                 765             


Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met 
    770                 775                 780                 


Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr 
785                 790                 795                 800 


Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu 
                805                 810                 815     


Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp 
            820                 825                 830         


Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe 
        835                 840                 845             


Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe 
    850                 855                 860                 


Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp 
865                 870                 875                 880 


Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr 
                885                 890                 895     


Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe 
            900                 905                 910         


Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
        915                 920                 925 


<210>  58
<211>  975
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  58

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Thr Ser Arg Ala Asn 
    50                  55                  60                  


Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu 
65                  70                  75                  80  


His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser 
                85                  90                  95      


Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile 
            100                 105                 110         


Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn 
    130                 135                 140                 


Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser 
145                 150                 155                 160 


Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn 
                165                 170                 175     


Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu 
            180                 185                 190         


Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys 
        195                 200                 205             


Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly 
    210                 215                 220                 


Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr 
225                 230                 235                 240 


Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn 
                245                 250                 255     


Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu 
            260                 265                 270         


Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly 
        275                 280                 285             


Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn 
    290                 295                 300                 


Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro 
305                 310                 315                 320 


Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln 
                325                 330                 335     


Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu 
            340                 345                 350         


Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala 
        355                 360                 365             


Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu 
    370                 375                 380                 


Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu 
385                 390                 395                 400 


Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr 
                405                 410                 415     


Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys 
            420                 425                 430         


His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys 
        435                 440                 445             


Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu 
    450                 455                 460                 


Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys 
465                 470                 475                 480 


Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu 
                485                 490                 495     


Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn 
            500                 505                 510         


Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr 
        515                 520                 525             


Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile 
    530                 535                 540                 


Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys 
545                 550                 555                 560 


Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp 
                565                 570                 575     


Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg 
            580                 585                 590         


Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys 
        595                 600                 605             


Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr 
    610                 615                 620                 


Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg 
625                 630                 635                 640 


Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile 
                645                 650                 655     


Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu 
            660                 665                 670         


Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His 
        675                 680                 685             


Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln 
    690                 695                 700                 


Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys 
705                 710                 715                 720 


Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr 
                725                 730                 735     


Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile 
            740                 745                 750         


Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe 
        755                 760                 765             


Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys 
    770                 775                 780                 


Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala 
785                 790                 795                 800 


Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser 
                805                 810                 815     


Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly 
            820                 825                 830         


Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile 
        835                 840                 845             


Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser 
    850                 855                 860                 


Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser 
865                 870                 875                 880 


Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys 
                885                 890                 895     


Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys 
            900                 905                 910         


Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg 
        915                 920                 925             


Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn 
    930                 935                 940                 


Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln 
945                 950                 955                 960 


Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975 


<210>  59
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  59

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Arg Val Val Asp Ile Ser Gly Phe Ser Ile Gly 
            500                 505                 510         


Ser Asp Gly His Ser Ile Gln Tyr Arg Asn Leu Leu Ala Trp Lys Tyr 
        515                 520                 525             


Leu Glu Asn Gly Lys Arg Glu Phe Tyr Leu Leu Met Asn Tyr Gly Lys 
    530                 535                 540                 


Lys Gly Arg Ile Arg Phe Thr Asp Gly Thr Asp Ile Lys Lys Ser Gly 
545                 550                 555                 560 


Lys Trp Gln Gly Leu Leu Tyr Gly Gly Gly Lys Ala Lys Val Ile Asp 
                565                 570                 575     


Leu Thr Phe Asp Pro Asp Asp Glu Gln Leu Ile Ile Leu Pro Leu Ala 
            580                 585                 590         


Phe Gly Thr Arg Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser 
        595                 600                 605             


Leu Glu Thr Gly Leu Ile Lys Leu Ala Asn Gly Arg Val Ile Glu Lys 
    610                 615                 620                 


Thr Ile Tyr Asn Lys Lys Ile Gly Arg Asp Glu Pro Ala Leu Phe Val 
625                 630                 635                 640 


Ala Leu Thr Phe Glu Arg Arg Glu Val Val Asp Pro Ser Asn Ile Lys 
                645                 650                 655     


Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val 
            660                 665                 670         


Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp 
        675                 680                 685             


Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys 
    690                 695                 700                 


Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg 
705                 710                 715                 720 


Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala 
                725                 730                 735     


Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val 
            740                 745                 750         


Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly 
        755                 760                 765             


Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met 
    770                 775                 780                 


Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr 
785                 790                 795                 800 


Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn 
                805                 810                 815     


Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys 
            820                 825                 830         


Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu 
        835                 840                 845             


Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln 
    850                 855                 860                 


Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu 
865                 870                 875                 880 


Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu 
                885                 890                 895     


Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu 
            900                 905                 910         


Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln 
        915                 920                 925             


Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu 
    930                 935                 940                 


Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg 
945                 950                 955                 960 


Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu 
                965                 970                 975     


Val Trp Lys Pro Ala Val 
            980         


<210>  60
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  60

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  61
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  61

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Ala Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala 
    


<210>  62
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  62

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  63
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  63

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Gln Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  64
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  64

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Gln Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  65
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  65

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Ile Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  66
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  66

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  67
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  67

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Thr Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  68
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  68

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Ser Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  69
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  69

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  70
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  70

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Lys Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  71
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  71

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  72
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  72

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  73
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  73

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  74
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  74

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Ser Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  75
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  75

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  76
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  76

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Asp Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  77
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  77

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Phe Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  78
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  78

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  79
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  79

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  80
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  80

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  81
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  81

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  82
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  82

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Lys Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  83
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  83

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Asn Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  84
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  84

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Met Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  85
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  85

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  86
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  86

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  87
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  87

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  88
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  88

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  89
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  89

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Val 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  90
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  90

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  91
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  91

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  92
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  92

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  93
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  93

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  94
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  94

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  95
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  95

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  96
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  96

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  97
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  97

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  98
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  98

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  99
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  99

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  100
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  100

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  101
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  101

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  102
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  102

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  103
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  103

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  104
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  104

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  105
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  105

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  106
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  106

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  107
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  107

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  108
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  108

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  109
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  109

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  110
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  110

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  111
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  111

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  112
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  112

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  113
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  113

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  114
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  114

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  115
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  115

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  116
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  116

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  117
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  117

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  118
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  118

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  119
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  119

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  120
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  120

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  121
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  121

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  122
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  122

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  123
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  123

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Met Ser Ser Gly 
        115                 120                 125             


Phe Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu 
    130                 135                 140                 


Gln Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys 
145                 150                 155                 160 


Asn Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro 
                165                 170                 175     


Glu Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  124
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  124

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  125
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  125

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  126
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  126

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  127
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  127

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  128
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  128

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  129
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  129

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  130
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  130

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  131
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  131

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  132
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  132

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  133
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  133

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  134
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  134

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  135
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  135

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  136
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  136

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  137
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  137

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  138
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  138

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  139
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  139

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  140
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  140

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Gly Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  141
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  141

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu 
                325                 330                 335     


Arg Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys 
            340                 345                 350         


Lys Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly 
        355                 360                 365             


Val Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu 
    370                 375                 380                 


Pro Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro 
385                 390                 395                 400 


Lys Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu 
                405                 410                 415     


Lys Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu 
            420                 425                 430         


Arg Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu 
        435                 440                 445             


Glu Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp 
    450                 455                 460                 


Trp Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met 
465                 470                 475                 480 


Asp Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr 
                485                 490                 495     


Gly Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Ser Ile 
            500                 505                 510         


Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile Trp 
        515                 520                 525             


Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn Tyr 
    530                 535                 540                 


Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala Phe 
545                 550                 555                 560 


Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu Ile 
                565                 570                 575     


Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile Ile 
            580                 585                 590         


Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp Asn 
        595                 600                 605             


Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly Arg 
    610                 615                 620                 


Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu Pro 
625                 630                 635                 640 


Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp Ser 
                645                 650                 655     


Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn 
            660                 665                 670         


Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser 
        675                 680                 685             


Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly 
    690                 695                 700                 


Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val 
705                 710                 715                 720 


Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala 
                725                 730                 735     


Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu 
            740                 745                 750         


Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser 
        755                 760                 765             


Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln 
    770                 775                 780                 


Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly 
785                 790                 795                 800 


Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys 
                805                 810                 815     


Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg 
            820                 825                 830         


Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile 
        835                 840                 845             


Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg 
    850                 855                 860                 


Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg 
865                 870                 875                 880 


Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly 
                885                 890                 895     


Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg 
            900                 905                 910         


Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His 
        915                 920                 925             


Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu 
    930                 935                 940                 


Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn 
945                 950                 955                 960 


Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys 
                965                 970                 975     


Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
            980                 985     


<210>  142
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  142

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Val Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro 
        675                 680                 685             


Thr Asp Ile Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Phe Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Ser Ala Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val 
            740                 745                 750         


Leu Val Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  143
<211>  972
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  143

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser 
    930                 935                 940                 


Tyr Lys Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr 
945                 950                 955                 960 


Lys Arg Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
                965                 970         


<210>  144
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  144

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


His Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  145
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  145

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  146
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  146

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn His Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  147
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  147

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Ala 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  148
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  148

Arg Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Ala Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala 
225                 230                 235                 240 


Ser Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val 
                245                 250                 255     


Val Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly 
            260                 265                 270         


Lys Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His 
        275                 280                 285             


Thr Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg 
    290                 295                 300                 


Met Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp 
305                 310                 315                 320 


Asp Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu 
                325                 330                 335     


Val Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn 
            340                 345                 350         


Val Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp 
        355                 360                 365             


Gln Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu 
    370                 375                 380                 


Ser Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln 
385                 390                 395                 400 


Leu Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp 
                405                 410                 415     


Gly Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu 
            420                 425                 430         


Gly Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp 
        435                 440                 445             


Ala Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser 
    450                 455                 460                 


Phe Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg 
465                 470                 475                 480 


Cys Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro 
                485                 490                 495     


Phe Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser 
            500                 505                 510         


Lys Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys 
        515                 520                 525             


Leu Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg 
    530                 535                 540                 


Phe Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr 
545                 550                 555                 560 


Val Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe 
                565                 570                 575     


Asn Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys 
            580                 585                 590         


Arg Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr 
        595                 600                 605             


Gly Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr 
    610                 615                 620                 


Asn Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr 
625                 630                 635                 640 


Phe Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn 
                645                 650                 655     


Leu Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu 
            660                 665                 670         


Thr Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly 
        675                 680                 685             


Asn Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln 
    690                 695                 700                 


Arg Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly 
705                 710                 715                 720 


Tyr Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met 
                725                 730                 735     


Val Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp 
            740                 745                 750         


Ala Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly 
        755                 760                 765             


Lys Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp 
    770                 775                 780                 


Leu Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  149
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  149

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Gln Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  150
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  150

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Thr Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  151
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  151

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Arg Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  152
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  152

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Tyr Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  153
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  153

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


His Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  154
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  154

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Ala Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  155
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  155

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  156
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  156

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  157
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  157

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  158
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  158

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Asn Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  159
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  159

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Trp Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  160
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  160

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Tyr Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  161
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  161

Arg Gln Arg Arg Asn Glu Leu Lys Arg Ser Pro 
1               5                   10      


<210>  162
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  162

Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly 
1               5                   10                  15      


Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro 
            20                  25                  30          


Arg Asn Gln Gly Gly Tyr 
        35              


<210>  163
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  163

Arg Met Arg Ile Glx Phe Lys Asn Lys Gly Lys Asp Thr Ala Glu Leu 
1               5                   10                  15      


Arg Arg Arg Arg Val Glu Val Ser Val Glu Leu Arg Lys Ala Lys Lys 
            20                  25                  30          


Asp Glu Gln Ile Leu Lys Arg Arg Asn Val 
        35                  40          


<210>  164
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  164

Val Ser Arg Lys Arg Pro Arg Pro 
1               5               


<210>  165
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  165

Pro Pro Lys Lys Ala Arg Glu Asp 
1               5               


<210>  166
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  166

Pro Gln Pro Lys Lys Lys Pro Leu 
1               5               


<210>  167
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  167

Ser Ala Leu Ile Lys Lys Lys Lys Lys Met Ala Pro 
1               5                   10          


<210>  168
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  168

Asp Arg Leu Arg Arg 
1               5   


<210>  169
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  169

Pro Lys Gln Lys Lys Arg Lys 
1               5           


<210>  170
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  170

Arg Lys Leu Lys Lys Lys Ile Lys Lys Leu 
1               5                   10  


<210>  171
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  171

Arg Glu Lys Lys Lys Phe Leu Lys Arg Arg 
1               5                   10  


<210>  172
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  172

Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys 
1               5                   10                  15      


Lys Ser Lys Lys 
            20  


<210>  173
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  173

Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys 
1               5                   10                  15      


Lys 
    


<210>  174
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  174

Pro Arg Pro Arg Lys Ile Pro Arg 
1               5               


<210>  175
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  175

Pro Pro Arg Lys Lys Arg Thr Val Val 
1               5                   


<210>  176
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  176

Asn Leu Ser Lys Lys Lys Lys Arg Lys Arg Glu Lys 
1               5                   10          


<210>  177
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  177

Arg Arg Pro Ser Arg Pro Phe Arg Lys Pro 
1               5                   10  


<210>  178
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  178

Lys Arg Pro Arg Ser Pro Ser Ser 
1               5               


<210>  179
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  179

Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg Gly Glu Asn Glu Arg 
1               5                   10                  15      


Lys Thr Arg 
            


<210>  180
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  180

Pro Arg Pro Pro Lys Met Ala Arg Tyr Asp Asn 
1               5                   10      


<210>  181
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  181

Lys Arg Ser Phe Ser Lys Ala Phe 
1               5               


<210>  182
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  182

Lys Leu Lys Ile Lys Arg Pro Val Lys 
1               5                   


<210>  183
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  183

Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Ala Ala Lys Arg Val 
1               5                   10                  15      


Lys Leu Asp 
            


<210>  184
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  184

Pro Lys Thr Arg Arg Arg Pro Arg Arg Ser Gln Arg Lys Arg Pro Pro 
1               5                   10                  15      


Thr 
    


<210>  185
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  185

Met Ser Arg Arg Arg Lys Ala Asn Pro Thr Lys Leu Ser Glu Asn Ala 
1               5                   10                  15      


Lys Lys Leu Ala Lys Glu Val Glu Asn 
            20                  25  


<210>  186
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  186

Lys Thr Arg Arg Arg Pro Arg Arg Ser Gln Arg Lys Arg Pro Pro Thr 
1               5                   10                  15      


<210>  187
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  187

Arg Arg Lys Lys Arg Arg Pro Arg Arg Lys Lys Arg Arg 
1               5                   10              


<210>  188
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  188

Pro Lys Lys Lys Ser Arg Lys Pro Lys Lys Lys Ser Arg Lys 
1               5                   10                  


<210>  189
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  189

His Lys Lys Lys His Pro Asp Ala Ser Val Asn Phe Ser Glu Phe Ser 
1               5                   10                  15      


Lys 
    


<210>  190
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  190

Gln Arg Pro Gly Pro Tyr Asp Arg Pro Gln Arg Pro Gly Pro Tyr Asp 
1               5                   10                  15      


Arg Pro 
        


<210>  191
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  191

Leu Ser Pro Ser Leu Ser Pro Leu Leu Ser Pro Ser Leu Ser Pro Leu 
1               5                   10                  15      


<210>  192
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  192

Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala Lys Arg His 
1               5                   10                  15      


Arg Lys 
        


<210>  193
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  193

Pro Lys Arg Gly Arg Gly Arg Pro Lys Arg Gly Arg Gly Arg 
1               5                   10                  


<210>  194
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  194

Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Ala Ala Lys Arg Val 
1               5                   10                  15      


Lys Leu Asp 
            


<210>  195
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  195

Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Lys Lys Lys Arg Lys 
1               5                   10                  15      


Val 
    


<210>  196
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  196

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  197
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  197

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  198
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide transduction domain

<400>  198

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  199
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide transduction domain

<400>  199

Arg Lys Lys Arg Arg Gln Arg Arg 
1               5               


<210>  200
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide transduction domain

<400>  200

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  201
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide transduction domain

<400>  201

Thr His Arg Leu Pro Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  202
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide transduction domain

<400>  202

Gly Gly Arg Arg Ala Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  203
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide transduction domain


<220>
<221>  SITE
<222>  (4)..(50)
<223>  individual amino acid residues may be present or absent

<400>  203

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
            20                  25                  30          


Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
        35                  40                  45              


Arg Arg 
    50  


<210>  204
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide transduction domain

<400>  204

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  205
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide transduction domain

<400>  205

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  206
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide transduction domain

<400>  206

Lys Ala Leu Ala Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala 
1               5                   10                  15      


Leu Ala Lys His Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu 
            20                  25                  30          


Ala 
    


<210>  207
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide transduction domain

<400>  207

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  208
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  SITE
<222>  (6)..(10)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (11)..(15)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (16)..(20)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (21)..(25)
<223>  grouped amino acid residues may be present or absent

<400>  208

Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Ser Gly Gly Ser Gly Ser Gly Gly Ser 
            20                  25  


<210>  209
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  SITE
<222>  (7)..(12)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (13)..(18)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (19)..(24)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (25)..(30)
<223>  grouped amino acid residues may be present or absent

<400>  209

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            20                  25                  30  


<210>  210
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  SITE
<222>  (5)..(8)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (9)..(12)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (13)..(16)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (17)..(20)
<223>  grouped amino acid residues may be present or absent

<400>  210

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  211
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  211

Gly Gly Ser Gly 
1               


<210>  212
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  212

Gly Gly Ser Gly Gly 
1               5   


<210>  213
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  213

Gly Ser Gly Ser Gly 
1               5   


<210>  214
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  214

Gly Ser Gly Gly Gly 
1               5   


<210>  215
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  215

Gly Gly Gly Ser Gly 
1               5   


<210>  216
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  216

Gly Ser Ser Ser Gly 
1               5   


<210>  217
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  217

Gly Pro Gly Pro 
1               


<210>  218
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  218

Pro Pro Ala Pro Pro Ala 
1               5       


<210>  219
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  219

Pro Pro Pro Gly Pro Pro Pro 
1               5           


<210>  220
<211>  3120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40 NLS-CasX-SV40 NLS-TEV cleavage site - TwinStrep tag

<400>  220
atggctccga agaagaagcg aaaggtcagc caggaaatta aacgcatcaa caagatccgc       60

cgtcgtctgg taaaagacag caatacgaaa aaagccggaa aaaccggtcc gatgaaaacg      120

ctgctggtgc gcgtgatgac gccggatctc cgcgaacgtc ttgagaattt gcgtaagaaa      180

cctgaaaata ttccgcaacc gatttctaac acctcgcgcg ccaatctgaa taaactgctg      240

accgattaca ccgaaatgaa gaaagcgatt ctgcacgttt actgggaaga gttccagaaa      300

gacccggtcg gtctgatgag ccgcgttgcg caacctgcgc cgaaaaatat cgatcagcgc      360

aagttaatcc cggttaaaga tggtaatgaa cgtttaacct ccagcggctt tgcctgcagt      420

cagtgctgcc agccacttta tgtttataaa cttgaacagg ttaacgataa agggaaaccc      480

cataccaatt atttcggccg ctgcaatgtc agcgaacatg aacgcctgat tttgttaagc      540

ccgcataaac cggaagcgaa tgacgaactg gtgacctatt ccctgggtaa atttggtcag      600

cgggcgctgg atttttacag cattcatgtg acgcgggaaa gtaaccatcc ggtaaagcca      660

ctggaacaaa tcggcggtaa cagctgcgcc tctggcccgg ttggcaaagc gcttagcgat      720

gcctgtatgg gcgcggtggc gagctttctg acaaaatacc aggatattat cctggagcat      780

cagaaggtga tcaaaaagaa cgagaaacgt ctggcaaatt taaaggatat tgcctccgct      840

aacggcctgg cgttcccgaa gattacctta ccgccgcagc cgcacaccaa agaaggtatc      900

gaagcgtata acaacgttgt tgcccagatc gtcatctggg tgaatctcaa cctgtggcaa      960

aaactgaaaa ttggtcgtga tgaagcaaaa ccgttgcagc gactgaaagg attcccgtcg     1020

tttccgctgg ttgaacgaca ggcgaacgaa gtggattggt gggatatggt ttgtaacgtc     1080

aaaaaattga tcaacgaaaa aaaggaagat ggcaaagttt tctggcaaaa tctggcgggt     1140

tacaaacgtc aggaggcgtt gcttccgtat ctctcttcag aagaagatcg caaaaaaggc     1200

aagaagtttg ctcgctatca gtttggcgat ttattactgc atctggaaaa aaaacacggc     1260

gaagactggg gcaaagtgta cgatgaagcc tgggagcgta tcgacaaaaa agtggaaggt     1320

ttgtcgaaac atattaaact cgaagaagag cgccgcagtg aagatgcgca gtcaaaagca     1380

gcgctgacgg actggttacg tgcgaaagcc agttttgtga ttgaaggatt aaaagaagct     1440

gataaagatg aattttgccg ttgcgaactg aaactgcaaa aatggtatgg cgacctgcgc     1500

ggcaaaccgt tcgccattga ggcagaaaat agcatccttg atatctccgg tttcagcaaa     1560

caatataact gcgcgtttat ttggcagaaa gacggcgtga aaaagcttaa cctgtatctg     1620

atcattaact attttaaagg cgggaaactg cgtttcaaga aaatcaagcc ggaagcattt     1680

gaagccaatc gtttttatac cgttattaat aaaaaaagcg gtgaaatcgt gccgatggaa     1740

gttaatttta actttgatga tccgaacttg attattctgc cgctggcatt cggtaaacgg     1800

cagggccgtg agtttatctg gaacgacctg ttatcgctgg aaacgggcag cctgaaatta     1860

gccaacggtc gcgtcattga aaaaacgctc tacaaccgcc gcacccgcca ggatgagccg     1920

gcactgtttg tcgcgctgac ctttgaacgg cgtgaagtcc tcgatagcag caacatcaaa     1980

ccaatgaacc ttatcggtat tgatcgtggt gaaaacattc ctgccgttat cgccctgact     2040

gatccagaag gctgcccgct ttctcgcttc aaagattcac tgggcaaccc gacccatatc     2100

ctccgtattg gcgagagcta caaagagaaa cagcgtacca ttcaggcagc caaagaagtg     2160

gagcagcgtc gcgcgggcgg ctatagccgt aaatatgcca gcaaagctaa aaacctggcg     2220

gatgacatgg tgcgtaacac ggcgcgcgat ttgctgtact acgccgtcac ccaggacgcg     2280

atgctgattt ttgagaacct ctcccgcggt tttgggcgtc agggtaaacg cacgtttatg     2340

gcggaacgcc agtatacgcg tatggaggac tggctgaccg cgaagctggc ctatgaaggc     2400

ttgccgtcta aaacttacct gagcaagacc ctggctcagt acaccagtaa aacctgtagt     2460

aattgcggct ttaccatcac cagcgccgat tatgaccgcg tgctggaaaa gctgaagaaa     2520

accgccaccg gctggatgac caccatcaat ggtaaagagc ttaaagtcga agggcagatt     2580

acttattaca accgttataa gcggcaaaac gtggtgaaag atctgtcggt tgagctggac     2640

cgtttgtctg aagaaagcgt gaacaatgat atcagctcct ggaccaaagg tcgttccggc     2700

gaagcgttaa gtctgttgaa aaagcgcttt agccatcgcc cggtgcagga aaaattcgtt     2760

tgcctgaact gtggcttcga aacccacgcc gacgagcaag cggcgctcaa tattgcgcgt     2820

agctggctgt tcctgcgcag ccaggaatat aaaaaatatc aaaccaacaa aacaactggc     2880

aataccgaca agcgtgcctt tgttgaaacc tggcagagct tctatcgcaa aaaactgaaa     2940

gaggtctgga aaccggcggt agcgccaaag aaaaaacgca aagtgagcga aaatctttat     3000

tttcaaggta gcgcatggag tcatcctcaa ttcgagaaag gtggaggttc tggcggtgga     3060

tcgggaggtt cagcgtggag ccacccgcag ttcgaaaaag gaaggggatc cggctgctaa     3120


<210>  221
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  221

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  222
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  222

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Pro 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  223
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  223

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  224
<211>  2928
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  224
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcccgctc ctaagaacat cgaccagaga aagctgatcc ccgtgaagga cggcaacgag      360

agactgacct ctagcggctt tgcctgcagc cagtgttgcc agcctctgta cgtgtacaag      420

ctggaacaag tgaacgacaa gggcaagccc cacaccaact acttcggcag atgcaacgtg      480

tccgagcacg agaggctgat cctgctgtct cctcacaagc ccgaggccaa cgatgagctg      540

gtcacataca gcctgggcaa gttcggacag agagccctgg acttctacag catccacgtg      600

accagggaga gcaatcaccc tgtgaagccc ctggaacaga tcggcggcaa tagctgtgcc      660

tctggacctg tgggaaaagc cctgagcgac gcctgtatgg gagccgtggc atccttcctg      720

accaagtacc aggacatcat cctggaacac cagaaagtga tcaagaagaa cgagaaaaga      780

ctggccaacc tcaaggatat cgccagcgct aacggcctgg cctttcctaa gatcaccctg      840

cctccacagc ctcacaccaa agagggcatc gaggcctaca acaacgtggt ggcccagatc      900

gtgatttggg tcaacctgaa tctgtggcag aagctgaaga tcggcaggga cgaagccaag      960

ccactgcaga gactgaaggg cttccctagc ttccctctgg tggaaagaca ggccaatgaa     1020

gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa gaaagaggat     1080

ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct gaggccttac     1140

ctgagcagcg aagaggaccg gaagaagggc aagaagttcg ccagatacca gttcggcgac     1200

ctgctgctgc acctggaaaa gaagcacggc gaggactggg gcaaagtgta cgatgaggcc     1260

tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct ggaagaggaa     1320

agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag agccaaggcc     1380

agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag atgcgagctg     1440

aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga ggccgagaac     1500

agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat ttggcagaaa     1560

gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg cggcaagctg     1620

cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac cgtgatcaac     1680

aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga ccccaacctg     1740

attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg gaacgatctg     1800

ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga gaaaaccctg     1860

tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac cttcgagaga     1920

agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcat cgaccggggc     1980

gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact gagcagattc     2040

aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta caaagagaag     2100

cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg atactctagg     2160

aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac cgccagagat     2220

ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct gagcagaggc     2280

ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag aatggaagat     2340

tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc caaaacactg     2400

gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag cgccgactac     2460

gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac catcaacggc     2520

aaagagctga aggttgaggg ccagatcacc tactacaaca ggtacaagag gcagaacgtc     2580

gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa caacgacatc     2640

agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa gaggtttagc     2700

cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac acacgccgat     2760

gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca agagtacaag     2820

aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt ggaaacctgg     2880

cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtg                  2928


<210>  225
<211>  2928
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  225
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcccgctc ctaagaacat cgaccagaga aagctgatcc ccgtgaagga cggcaacgag      360

agactgacct ctagcggctt tgcctgcagc cagtgttgcc agcctctgta cgtgtacaag      420

ctggaacaag tgaacgacaa gggcaagccc cacaccaact acttcggcag atgcaacgtg      480

tccgagcacg agaggctgat cctgctgtct cctcacaagc ccgaggccaa cgatgagctg      540

gtcacataca gcctgggcaa gttcggacag agagccctgg acttctacag catccacgtg      600

accagggaga gcaatcaccc tgtgaagccc ctggaacaga tcggcggcaa tagctgtgcc      660

tctggacctg tgggaaaagc cctgagcgac gcctgtatgg gagccgtggc atccttcctg      720

accaagtacc aggacatcat cctggaacac aagaaagtga tcaagaagaa cgagaaaaga      780

ctggccaacc tcaaggatat cgccagcgct aacggcctgg cctttcctaa gatcaccctg      840

cctccacagc ctcacaccaa agagggcatc gaggcctaca acaacgtggt ggcccagatc      900

gtgatttggg tcaacctgaa tctgtggcag aagctgaaga tcggcaggga cgaagccaag      960

ccactgcaga gactgaaggg cttccctagc ttccctctgg tggaaagaca ggccaatgaa     1020

gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa gaaagaggat     1080

ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct gaggccttac     1140

ctgagcagcc ccgaggaccg gaagaagggc aagaagttcg ccagatacca gctgggcgac     1200

ctgctgctgc acctggaaaa gaagcacggc gaggactggg gcaaagtgta cgatgaggcc     1260

tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct ggaagaggaa     1320

agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag agccaaggcc     1380

agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag atgcgagctg     1440

aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga ggccgagaac     1500

agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat ttggcagaaa     1560

gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg cggcaagctg     1620

cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac cgtgatcaac     1680

aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga ccccaacctg     1740

attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg gaacgatctg     1800

ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga gaaacccctg     1860

tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac cttcgagaga     1920

agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcgt ggaccggggc     1980

gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact gagcagattc     2040

aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta caaagagaag     2100

cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg atactctagg     2160

aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac cgccagagat     2220

ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct gagcagaggc     2280

ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag aatggaagat     2340

tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc caaaacactg     2400

gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag cgccgactac     2460

gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac catcaacggc     2520

aaagagctga aggttgaggg ccagatcacc tactacaaca ggaggaagag gcagaacgtc     2580

gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa caacgacatc     2640

agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa gaggtttagc     2700

cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac acacgccgat     2760

gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca agagtacaag     2820

aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt ggaaacctgg     2880

cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtg                  2928


<210>  226
<211>  2928
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  226
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcccgctc ctaagaacat cgaccagaga aagctgatcc ccgtgaagga cggcaacgag      360

agactgacct ctagcggctt tgcctgcagc cagtgttgcc agcctctgta cgtgtacaag      420

ctggaacaag tgaacgacaa gggcaagccc cacaccaact acttcggcag atgcaacgtg      480

tccgagcacg agaggctgat cctgctgtct cctcacaagc ccgaggccaa cgatgagctg      540

gtcacataca gcctgggcaa gttcggacag agagccctgg acttctacag catccacgtg      600

accagggaga gcaatcaccc tgtgaagccc ctggaacaga tcggcggcaa tagctgtgcc      660

tctggacctg tgggaaaagc cctgagcgac gcctgtatgg gagccgtggc atccttcctg      720

accaagtacc aggacatcat cctggaacac cagaaagtga tcaagaagaa cgagaaaaga      780

ctggccaacc tcaaggatat cgccagcgct aacggcctgg cctttcctaa gatcaccctg      840

cctccacagc ctcacaccaa agagggcatc gaggcctaca acaacgtggt ggcccagatc      900

gtgatttggg tcaacctgaa tctgtggcag aagctgaaga tcggcaggga cgaagccaag      960

ccactgcaga gactgaaggg cttccctagc ttccctctgg tggaaagaca ggccaatgaa     1020

gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa gaaagaggat     1080

ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct gaggccttac     1140

ctgagcagcg aagaggaccg gaagaagggc aagaagttcg ccagatacca gctgggcgac     1200

ctgctgaagc acctggaaaa gaagcacggc gaggactggg gcaaagtgta cgatgaggcc     1260

tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct ggaagaggaa     1320

agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag agccaaggcc     1380

agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag atgcgagctg     1440

aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga ggccgagaac     1500

agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat ttggcagaaa     1560

gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg cggcaagctg     1620

cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac cgtgatcaac     1680

aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga ccccaacctg     1740

attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg gaacgatctg     1800

ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga gaaaaccctg     1860

tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac cttcgagaga     1920

agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcgt ggaccggggc     1980

gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact gagcagattc     2040

aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta caaagagaag     2100

cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg atactctagg     2160

aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac cgccagagat     2220

ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct gagcagaggc     2280

ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag aatggaagat     2340

tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc caaaacactg     2400

gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag cgccgactac     2460

gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac catcaacggc     2520

aaagagctga aggttgaggg ccagatcacc tactacaaca ggaggaagag gcagaacgtc     2580

gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa caacgacatc     2640

agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa gaggtttagc     2700

cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac acacgccgat     2760

gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca agagtacaag     2820

aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt ggaaacctgg     2880

cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtg                  2928


<210>  227
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  227

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  228
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  228

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  229
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  229

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  230
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  230

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  231
<211>  2931
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  231
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagttcggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg catcgaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     2400

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     2460

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     2520

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggtacaa gaggcagaac     2580

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     2640

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     2700

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     2760

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     2820

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     2880

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt g              2931


<210>  232
<211>  2931
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  232
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     2400

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     2460

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     2520

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggtacaa gaggcagaac     2580

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     2640

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     2700

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     2760

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     2820

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     2880

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt g              2931


<210>  233
<211>  2934
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  233
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgccca gcaagaccta cctgtccaaa     2400

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     2460

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     2520

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     2580

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     2640

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     2700

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     2760

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     2820

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     2880

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtg           2934


<210>  234
<211>  2934
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  234
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacacgggg ccccatgaaa accctgctcg tcagagtgat gacccctgac      120

ctgagagagc ggctggaaaa cctgagaaag aagcccgaga acatccctca gcctatcagc      180

aacaccagca gggccaacct gaacaagctg ctgaccgact acaccgagat gaagaaagcc      240

atcctgcacg tgtactggga agagttccag aaagaccccg tgggcctgat gagcagagtt      300

gctcagcctg ccagcaagaa gatcgaccag aacaagctga agcccgagat ggacgagaag      360

ggcaatctga ccacagccgg ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac      420

aagctggaac aggtgtccga gaaaggcaag gcctacacca actacttcgg cagatgtaac      480

gtggccgagc acgagaagct gattctgctg gcccagctga aacctgagaa ggactctgat      540

gaggccgtga cctacagcct gggcaagttt ggacagagag ccctggactt ctacagcatc      600

cacgtgacca aagaaagcac acaccccgtg aagcccctgg ctcagatcgc cggcaataga      660

tacgcctctg gacctgtggg caaagccctg tccgatgcct gcatgggaac aatcgccagc      720

ttcctgagca agtaccagga catcatcatc gagcaccaga aggtggtcaa gggcaaccag      780

aagagactgg aaagcctgag ggagctggcc ggcaaagaga acctggaata ccccagcgtg      840

accctgcctc ctcagcctca cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc      900

agagtgagaa tgtgggtcaa cctgaacctg tggcagaagc tgaaactgtc cagggacgac      960

gccaagcctc tgctgagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc     1020

aatgaagtgg attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa     1080

gaggatggca aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg     1140

ccttacctga gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg     1200

ggcgacctgc tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat     1260

gaggcctggg agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa     1320

gaggaaagaa ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc     1380

aaggccagct ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc     1440

gagctgaagc tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc     1500

gagaacagca tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg     1560

cagaaagacg gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc     1620

aagctgcggt tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg     1680

atcaacaaaa agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc     1740

aacctgatta tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac     1800

gatctgctga gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa     1860

accctgtaca acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc     1920

gagagaagag aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac     1980

cggggcgaga atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc     2040

agattcaagg actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa     2100

gagaagcaga ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac     2160

tctaggaagt acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc     2220

agagatctgc tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc     2280

agaggcttcg gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg     2340

gaagattggc tcacagctaa actggcctac gagggactga gcaagaccta cctgtccaaa     2400

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     2460

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     2520

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     2580

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     2640

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     2700

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     2760

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     2820

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     2880

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtg           2934


<210>  235
<211>  987
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  235

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu Gln 
    210                 215                 220                 


Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg Leu 
            260                 265                 270         


Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro Lys 
        275                 280                 285             


Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala Tyr 
    290                 295                 300                 


Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
            980                 985         


<210>  236
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  236

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val 
            980                 985     


<210>  237
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  237

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val 
        995     


<210>  238
<211>  1006
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  238

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro His Lys Lys 
            980                 985                 990         


Lys His Pro Asp Ala Ser Val Asn  Phe Ser Glu Phe Ser  Lys 
        995                 1000                 1005     


<210>  239
<211>  1007
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  239

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Gln Arg Pro 
            980                 985                 990         


Gly Pro Tyr Asp Arg Pro Gln Arg  Pro Gly Pro Tyr Asp  Arg Pro 
        995                 1000                 1005         


<210>  240
<211>  1005
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  240

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Leu Ser Pro 
            980                 985                 990         


Ser Leu Ser Pro Leu Leu Ser Pro  Ser Leu Ser Pro Leu  
        995                 1000                 1005 


<210>  241
<211>  1008
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  241

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Met Ser Ser Gly 
        115                 120                 125             


Phe Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu 
    130                 135                 140                 


Gln Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys 
145                 150                 155                 160 


Asn Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro 
                165                 170                 175     


Glu Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Arg Gly 
            980                 985                 990         


Lys Gly Gly Lys Gly Leu Gly Lys  Gly Gly Ala Lys Arg  His Arg Lys 
        995                 1000                 1005             


<210>  242
<211>  1013
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  242

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Ser Arg Arg 
            980                 985                 990         


Arg Lys Ala Asn Pro Thr Lys Leu  Ser Glu Asn Ala Lys  Lys Leu Ala 
        995                 1000                 1005             


Lys Glu  Val Glu Asn 
    1010             


<210>  243
<211>  998
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  243

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Ala Ala 
            980                 985                 990         


Lys Arg Val Lys Leu Asp 
        995             


<210>  244
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  244

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Lys Arg Ser 
            980                 985                 990         


Phe Ser Lys Ala Phe 
        995         


<210>  245
<211>  1008
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  245

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Lys Arg Gly 
            980                 985                 990         


Ile Asn Asp Arg Asn Phe Trp Arg  Gly Glu Asn Glu Arg  Lys Thr Arg 
        995                 1000                 1005             


<210>  246
<211>  1007
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  246

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Met Gln Glu Ile Lys 
1               5                   10                  15      


Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys 
            20                  25                  30          


Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met 
        35                  40                  45              


Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu 
    50                  55                  60                  


Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys 
65                  70                  75                  80  


Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr 
                85                  90                  95      


Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala 
            100                 105                 110         


Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys 
        115                 120                 125             


Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys 
    130                 135                 140                 


Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly 
145                 150                 155                 160 


Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu 
                165                 170                 175     


Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu 
    210                 215                 220                 


Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg 
            260                 265                 270         


Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro 
        275                 280                 285             


Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala 
    290                 295                 300                 


Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val Pro Pro Pro  Pro Lys Lys Lys Arg  Lys Val 
        995                 1000                 1005         


<210>  247
<211>  1009
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  247

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Met Gln Glu Ile Lys 
1               5                   10                  15      


Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys 
            20                  25                  30          


Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met 
        35                  40                  45              


Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu 
    50                  55                  60                  


Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys 
65                  70                  75                  80  


Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr 
                85                  90                  95      


Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala 
            100                 105                 110         


Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys 
        115                 120                 125             


Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys 
    130                 135                 140                 


Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly 
145                 150                 155                 160 


Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu 
                165                 170                 175     


Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu 
    210                 215                 220                 


Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg 
            260                 265                 270         


Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro 
        275                 280                 285             


Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala 
    290                 295                 300                 


Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val Pro Pro Pro  Pro Ala Ala Lys Arg  Val Lys Leu 
        995                 1000                 1005             


Asp 
    


<210>  248
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  248

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  249
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  249
ccaaagaaga agcggaaggt c                                                 21


<210>  250
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  250
cacaagaaga aacatccaga cgcatcagtc aactttagcg agttcagtaa a                51


<210>  251
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  251
cagcgccctg ggccttacga taggccgcaa agacccggac cgtatgatcg ccct             54


<210>  252
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  252
ctcagcccga gtcttagtcc actgctttcc ccgtccctgt ctccactg                    48


<210>  253
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  253
cggggcaagg gtggcaaggg gcttggcaag gggggggcaa agaggcacag gaag             54


<210>  254
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  254
agccgccgca gaaaagccaa tcctacaaaa ctgtcagaaa atgcgaaaaa acttgctaag       60

gaggtggaaa ac                                                           72


<210>  255
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  255
cctgccgcaa agcgagtgaa attggac                                           27


<210>  256
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  256
aagcggtcct tcagtaaggc cttt                                              24


<210>  257
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  257
aaacggggaa taaacgaccg gaacttctgg cgcggggaaa acgagcgcaa aacccga          57


<210>  258
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  258

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu 
    210                 215                 220                 


Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg 
            260                 265                 270         


Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro 
        275                 280                 285             


Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala 
    290                 295                 300                 


Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  259
<211>  1005
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  259

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala Gln 
    210                 215                 220                 


Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg Leu 
            260                 265                 270         


Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro Ser 
        275                 280                 285             


Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala Tyr 
    290                 295                 300                 


Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val Thr Ser Pro Lys  Lys Lys Arg Lys Val  
        995                 1000                 1005 


<210>  260
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  260

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala Gln 
    210                 215                 220                 


Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg Leu 
            260                 265                 270         


Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro Ser 
        275                 280                 285             


Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala Tyr 
    290                 295                 300                 


Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val 
        995     


<210>  261
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  261

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala Gln 
    210                 215                 220                 


Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg Leu 
            260                 265                 270         


Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro Ser 
        275                 280                 285             


Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala Tyr 
    290                 295                 300                 


Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Lys His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val 
        995     


<210>  262
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  262

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala Gln 
    210                 215                 220                 


Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg Leu 
            260                 265                 270         


Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro Ser 
        275                 280                 285             


Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala Tyr 
    290                 295                 300                 


Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val 
        995     


<210>  263
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  263

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala 
    210                 215                 220                 


Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro 
        275                 280                 285             


Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala 
    290                 295                 300                 


Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  264
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  264

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala 
    210                 215                 220                 


Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro 
        275                 280                 285             


Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala 
    290                 295                 300                 


Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  265
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  265

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala 
    210                 215                 220                 


Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro 
        275                 280                 285             


Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala 
    290                 295                 300                 


Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Lys His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  266
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  266

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala 
    210                 215                 220                 


Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro 
        275                 280                 285             


Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala 
    290                 295                 300                 


Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  267
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  267

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu 
    210                 215                 220                 


Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg 
            260                 265                 270         


Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro 
        275                 280                 285             


Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala 
    290                 295                 300                 


Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  268
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  268
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca gggagagcaa tcaccctgtg      660

aagcccctgg aacagatcgg cggcaatagc tgtgcctctg gacctgtggg aaaagccctg      720

agcgacgcct gtatgggagc cgtggcatcc ttcctgacca agtaccagga catcatcctg      780

gaacaccaga aagtgatcaa gaagaacgag aaaagactgg ccaacctcaa ggatatcgcc      840

agcgctaacg gcctggcctt tcctaagatc accctgcctc cacagcctca caccaaagag      900

ggcatcgagg cctacaacaa cgtggtggcc cagatcgtga tttgggtcaa cctgaatctg      960

tggcagaagc tgaagatcgg cagggacgaa gccaagccac tgcagagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagttc ggcgacctgc tgctgcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcatcgac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  269
<211>  2988
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  269
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcccg ctcctaagaa catcgaccag      360

agaaagctga tccccgtgaa ggacggcaac gagagactga cctctagcgg ctttgcctgc      420

agccagtgtt gccagcctct gtacgtgtac aagctggaac aagtgaacga caagggcaag      480

ccccacacca actacttcgg cagatgcaac gtgtccgagc acgagaggct gatcctgctg      540

tctcctcaca agcccgaggc caacgatgag ctggtcacat acagcctggg caagttcgga      600

cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag      660

cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc      720

gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag      780

caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc      840

aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc      900

gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg      960

cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct     1020

agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac     1080

gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc     1140

ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag     1200

ggcaagaagt tcgccagata ccagttcggc gacctgctgc tgcacctgga aaagaagcac     1260

ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa     1320

ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa     1380

gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag     1440

gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg     1500

agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc     1560

aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac     1620

ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc     1680

ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg     1740

gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag     1800

agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag     1860

ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag     1920

cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc     1980

aagcccatga acctgatcgg catcgaccgg ggcgagaata tccctgctgt gatcgccctg     2040

acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac     2100

atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag     2160

gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg     2220

gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac     2280

gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt     2340

atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag     2400

ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc     2460

aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa     2520

accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc     2580

acctactaca acaggtacaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac     2640

agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc     2700

gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg     2760

tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga     2820

agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc     2880

aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa     2940

gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggta                  2988


<210>  270
<211>  2988
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  270
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcccg ctcctaagaa catcgaccag      360

agaaagctga tccccgtgaa ggacggcaac gagagactga cctctagcgg ctttgcctgc      420

agccagtgtt gccagcctct gtacgtgtac aagctggaac aagtgaacga caagggcaag      480

ccccacacca actacttcgg cagatgcaac gtgtccgagc acgagaggct gatcctgctg      540

tctcctcaca agcccgaggc caacgatgag ctggtcacat acagcctggg caagttcgga      600

cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag      660

cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc      720

gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag      780

caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc      840

aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc      900

gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg      960

cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct     1020

agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac     1080

gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc     1140

ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag     1200

ggcaagaagt tcgccagata ccagctgggc gacctgctgc tgcacctgga aaagaagcac     1260

ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa     1320

ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa     1380

gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag     1440

gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg     1500

agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc     1560

aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac     1620

ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc     1680

ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg     1740

gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag     1800

agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag     1860

ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag     1920

cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc     1980

aagcccatga acctgatcgg cgtggaccgg ggcgagaata tccctgctgt gatcgccctg     2040

acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac     2100

atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag     2160

gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg     2220

gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac     2280

gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt     2340

atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag     2400

ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc     2460

aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa     2520

accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc     2580

acctactaca acaggaggaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac     2640

agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc     2700

gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg     2760

tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga     2820

agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc     2880

aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa     2940

gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggta                  2988


<210>  271
<211>  2988
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  271
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcccg ctcctaagaa catcgaccag      360

agaaagctga tccccgtgaa ggacggcaac gagagactga cctctagcgg ctttgcctgc      420

agccagtgtt gccagcctct gtacgtgtac aagctggaac aagtgaacga caagggcaag      480

ccccacacca actacttcgg cagatgcaac gtgtccgagc acgagaggct gatcctgctg      540

tctcctcaca agcccgaggc caacgatgag ctggtcacat acagcctggg caagttcgga      600

cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag      660

cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc      720

gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag      780

caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc      840

aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc      900

gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg      960

cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct     1020

agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac     1080

gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc     1140

ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag     1200

ggcaagaagt tcgccagata ccagctgggc gacctgctga agcacctgga aaagaagcac     1260

ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa     1320

ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa     1380

gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag     1440

gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg     1500

agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc     1560

aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac     1620

ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc     1680

ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg     1740

gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag     1800

agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag     1860

ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag     1920

cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc     1980

aagcccatga acctgatcgg cgtggaccgg ggcgagaata tccctgctgt gatcgccctg     2040

acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac     2100

atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag     2160

gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg     2220

gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac     2280

gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt     2340

atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag     2400

ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc     2460

aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa     2520

accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc     2580

acctactaca acaggaggaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac     2640

agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc     2700

gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg     2760

tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga     2820

agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc     2880

aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa     2940

gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggta                  2988


<210>  272
<211>  2988
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  272
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcccg ctcctaagaa catcgaccag      360

agaaagctga tccccgtgaa ggacggcaac gagagactga cctctagcgg ctttgcctgc      420

agccagtgtt gccagcctct gtacgtgtac aagctggaac aagtgaacga caagggcaag      480

ccccacacca actacttcgg cagatgcaac gtgtccgagc acgagaggct gatcctgctg      540

tctcctcaca agcccgaggc caacgatgag ctggtcacat acagcctggg caagttcgga      600

cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag      660

cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc      720

gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag      780

caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc      840

aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc      900

gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg      960

cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct     1020

agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac     1080

gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc     1140

ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag     1200

ggcaagaagt tcgccagata ccagctgggc gacctgctgc tgcacctgga aaagaagcac     1260

ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa     1320

ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa     1380

gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag     1440

gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg     1500

agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc     1560

aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac     1620

ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc     1680

ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg     1740

gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag     1800

agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag     1860

ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag     1920

cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc     1980

aagcccatga acctgatcgg cgtggaccgg ggcgagaata tccctgctgt gatcgccctg     2040

acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac     2100

atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag     2160

gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg     2220

gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac     2280

gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt     2340

atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag     2400

ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc     2460

aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa     2520

accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc     2580

acctactaca acaggtacaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac     2640

agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc     2700

gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg     2760

tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga     2820

agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc     2880

aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa     2940

gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggta                  2988


<210>  273
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  273
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac acaccccgtg      660

aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg caaagccctg      720

tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga catcatcatc      780

gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag ggagctggcc      840

ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca cacaaaagaa      900

ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa cctgaacctg      960

tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagttc ggcgacctgc tgctgcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcatcgac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  274
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  274
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac acaccccgtg      660

aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg caaagccctg      720

tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga catcatcatc      780

gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag ggagctggcc      840

ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca cacaaaagaa      900

ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa cctgaacctg      960

tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagctg ggcgacctgc tgctgcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggag gaagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  275
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  275
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac acaccccgtg      660

aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg caaagccctg      720

tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga catcatcatc      780

gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag ggagctggcc      840

ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca cacaaaagaa      900

ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa cctgaacctg      960

tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagctg ggcgacctgc tgaagcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggag gaagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  276
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  276
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac acaccccgtg      660

aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg caaagccctg      720

tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga catcatcatc      780

gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag ggagctggcc      840

ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca cacaaaagaa      900

ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa cctgaacctg      960

tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagctg ggcgacctgc tgctgcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  277
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  277
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca gggagagcaa tcaccctgtg      660

aagcccctgg aacagatcgg cggcaatagc tgtgcctctg gacctgtggg aaaagccctg      720

agcgacgcct gtatgggagc cgtggcatcc ttcctgacca agtaccagga catcatcctg      780

gaacaccaga aagtgatcaa gaagaacgag aaaagactgg ccaacctcaa ggatatcgcc      840

agcgctaacg gcctggcctt tcctaagatc accctgcctc cacagcctca caccaaagag      900

ggcatcgagg cctacaacaa cgtggtggcc cagatcgtga tttgggtcaa cctgaatctg      960

tggcagaagc tgaagatcgg cagggacgaa gccaagccac tgcagagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagctg ggcgacctgc tgctgcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  278
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T7 promoter primer

<400>  278
gaaattaata cgactcacta ta                                                22


<210>  279
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg2 backbone fwd primer

<400>  279
gaaattaata cgactcacta taggtactgg cgcttttatc tcattacttt gagagccatc       60

accagcgact atgtcgtatg ggtaaag                                           87


<210>  280
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg2 backbone rev primer

<400>  280
ctttgatgct tcttatttat cggatttctc tccgataaat aagcgcttta cccatacgac       60

atagtcgctg gtgatggc                                                     78


<210>  281
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg2.7.37 spacer primer

<400>  281
cggagcgaga catctcggcc ctttgatgct tcttatttat cggatttctc tccg             54


<210>  282
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg32 backbone fwd primer

<400>  282
gaaattaata cgactcacta taggtactgg cgcttttatc tcattacttt gagagccatc       60

accagcgact atgtcgtatg ggtaaagcgc                                        90


<210>  283
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg32 backbone rev primer

<400>  283
ctttgatgct tccctccgaa gagggcgctt tacccatacg acatag                      46


<210>  284
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg32.7.37 spacer primer

<400>  284
cggagcgaga catctcggcc ctttgatgct tccctccgaa gag                         43


<210>  285
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg64 backbone fwd primer

<400>  285
gaaattaata cgactcacta taggtactgg cgcctttatc tcattacttt gagagccatc       60

accagcgact atgtcgtatg ggtaaagcgc                                        90


<210>  286
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg64 backbone rev primer

<400>  286
ctttgatgct tcttacggac cgaagtccgt aagcgcttta cccatacgac atag             54


<210>  287
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg64.7.37 spacer primer

<400>  287
cggagcgaga catctcggcc ctttgatgct tcttacggac cgaag                       45


<210>  288
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg174 backbone fwd primer

<400>  288
gaaattaata cgactcacta taactggcgc ttttatctga ttactttgag agccatcacc       60

agcgactatg tcgtagtggg taaagct                                           87


<210>  289
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg174 backbone rev primer

<400>  289
ctttgatgct ccctccgaag agggagcttt acccactacg acatagtcgc                  50


<210>  290
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg174.7.37 spacer primer

<400>  290
cggagcgaga catctcggcc ctttgatgct ccctcc                                 36


<210>  291
<211>  130
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  291
gguacuggcg cuuuuaucuc auuacuuuga gagccaucac cagcgacuau gucguauggg       60

uaaagcgcuu auuuaucgga gagaaauccg auaaauaaga agcaucaaag ggccgagaug      120

ucucgcuccg                                                             130


<210>  292
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  292
gguacuggcg cuuuuaucuc auuacuuuga gagccaucac cagcgacuau gucguauggg       60

uaaagcgccc ucuucggagg gaagcaucaa agggccgaga ugucucg                    107


<210>  293
<211>  120
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  293
gguacuggcg ccuuuaucuc auuacuuuga gagccaucac cagcgacuau gucguauggg       60

uaaagcgcuu acggacuucg guccguaaga agcaucaaag ggccgagaug ucucgcuccg      120


<210>  294
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  294
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaagg gccgagaugu cucgcuccg                  109


<210>  295
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  295
gaggaggacg gcctggccga                                                   20


<210>  296
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  296
accgctgcgc caaggtgcgg                                                   20


<210>  297
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  297
gccaggccgt cctcctcgga                                                   20


<210>  298
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  298
gtgctcgggt gcttcggcca                                                   20


<210>  299
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  299
atggccttct tcctggcttc                                                   20


<210>  300
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  300
gcaccaccac gtaggtgcca                                                   20


<210>  301
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  301
tcctggcttc ctggtgaaga                                                   20


<210>  302
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  302
tggcttcctg gtgaagatga                                                   20


<210>  303
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  303
ccaggaagcc aggaagaagg                                                   20


<210>  304
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  304
tccttgcatg gggccaggat                                                   20


<210>  305
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  305
ggcggcaagt tctgctcagc                                                   20


<210>  306
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  306
tctccacgat cgtcagcgtg                                                   20


<210>  307
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  307
acgatcgtca gcgtgagtgc                                                   20


<210>  308
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  308
ctctagcaat ggatcgtggg                                                   20


<210>  309
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  309
caaacaaatg tgtcacaaag                                                   20


<210>  310
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  310
gatgtgtata tcacagacaa                                                   20


<210>  311
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  311
ggaataatgc tgttgttgaa                                                   20


<210>  312
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  312
aaatccagtg acaagtctgt                                                   20


<210>  313
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  313
aggccacagc actgttgctc                                                   20


<210>  314
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  314
agaagacacc ttcttcccca                                                   20


<210>  315
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  315
tccccagccc aggtaagggc                                                   20


<210>  316
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  316
ccagcccagg taagggcagc                                                   20


<210>  317
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  317
agtccctcaa gtccttccag                                                   20


<210>  318
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  318
agcagcagca gcagcagcag                                                   20


<210>  319
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  319
tcagccgccg ccgcaggcac                                                   20


<210>  320
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  320
agggtcgcca tggcggtctc                                                   20


<210>  321
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  321
tcagcttttc cagggtcgcc                                                   20


<210>  322
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  322
gccgcagccg cccccgccgc                                                   20


<210>  323
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  323
gccacagccg ggccgggtgg                                                   20


<210>  324
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  324
tcagccacag ccgggccggg                                                   20


<210>  325
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  325
cggtcggtgc agcggctcct                                                   20


<210>  326
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  326
ccacaccttc actggtccat                                                   20


<210>  327
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  327
taaaggaaag taatggacca                                                   20


<210>  328
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  328
ctggtccatt actttccttt                                                   20


<210>  329
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  329
atgttcatga gtttggagat                                                   20


<210>  330
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  330
tgagtttgga gataatacag                                                   20


<210>  331
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  331
atagacacat cggccacacc                                                   20


<210>  332
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  332
ttattaggca tgttggagac                                                   20


<210>  333
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  333
caggagacca ttgcatcatt                                                   20


<210>  334
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  334
ggcctggagg ctatccagcg                                                   20


<210>  335
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  335
ggccgagatg tctcgctccg                                                   20


<210>  336
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  336
aggccagaaa gagagagtag                                                   20


<210>  337
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  337
cgctggatag cctccaggcc                                                   20


<210>  338
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  338
tgaagctgac agcattcggg                                                   20


<210>  339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  339
gaggaggacg gccuggccga                                                   20


<210>  340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  340
accgcugcgc caaggugcgg                                                   20


<210>  341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  341
gccaggccgu ccuccucgga                                                   20


<210>  342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  342
gugcucgggu gcuucggcca                                                   20


<210>  343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  343
auggccuucu uccuggcuuc                                                   20


<210>  344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  344
gcaccaccac guaggugcca                                                   20


<210>  345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  345
uccuggcuuc cuggugaaga                                                   20


<210>  346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  346
uggcuuccug gugaagauga                                                   20


<210>  347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  347
ccaggaagcc aggaagaagg                                                   20


<210>  348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  348
uccuugcaug gggccaggau                                                   20


<210>  349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  349
ggcggcaagu ucugcucagc                                                   20


<210>  350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  350
ucuccacgau cgucagcgug                                                   20


<210>  351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  351
acgaucguca gcgugagugc                                                   20


<210>  352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  352
cucuagcaau ggaucguggg                                                   20


<210>  353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  353
caaacaaaug ugucacaaag                                                   20


<210>  354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  354
gauguguaua ucacagacaa                                                   20


<210>  355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  355
ggaauaaugc uguuguugaa                                                   20


<210>  356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  356
aaauccagug acaagucugu                                                   20


<210>  357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  357
aggccacagc acuguugcuc                                                   20


<210>  358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  358
agaagacacc uucuucccca                                                   20


<210>  359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  359
uccccagccc agguaagggc                                                   20


<210>  360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  360
ccagcccagg uaagggcagc                                                   20


<210>  361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  361
agucccucaa guccuuccag                                                   20


<210>  362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  362
agcagcagca gcagcagcag                                                   20


<210>  363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  363
ucagccgccg ccgcaggcac                                                   20


<210>  364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  364
agggucgcca uggcggucuc                                                   20


<210>  365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  365
ucagcuuuuc cagggucgcc                                                   20


<210>  366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  366
gccgcagccg cccccgccgc                                                   20


<210>  367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  367
gccacagccg ggccgggugg                                                   20


<210>  368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  368
ucagccacag ccgggccggg                                                   20


<210>  369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  369
cggucggugc agcggcuccu                                                   20


<210>  370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  370
ccacaccuuc acugguccau                                                   20


<210>  371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  371
uaaaggaaag uaauggacca                                                   20


<210>  372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  372
cugguccauu acuuuccuuu                                                   20


<210>  373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  373
auguucauga guuuggagau                                                   20


<210>  374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  374
ugaguuugga gauaauacag                                                   20


<210>  375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  375
auagacacau cggccacacc                                                   20


<210>  376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  376
uuauuaggca uguuggagac                                                   20


<210>  377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  377
caggagacca uugcaucauu                                                   20


<210>  378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  378
ggccuggagg cuauccagcg                                                   20


<210>  379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  379
ggccgagaug ucucgcuccg                                                   20


<210>  380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  380
aggccagaaa gagagaguag                                                   20


<210>  381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  381
cgcuggauag ccuccaggcc                                                   20


<210>  382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  382
ugaagcugac agcauucggg                                                   20


<210>  383
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer target oligo

<400>  383
tgaagctgac agcattcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  384
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer target oligo

<400>  384
tgaagctgac agcattcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  385
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HDV antigenomic ribozyme

<400>  385
gggtcggcat ggcatctcca cctcctcgcg gtccgacctg ggcatccgaa ggaggacgca       60

cgtccactcg gatggctaag ggagagcca                                         89


<210>  386
<211>  86
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HDV genomic ribozyme

<400>  386
ggccggcatg gtcccagcct cctcgctggc gccggctggg caacattccg aggggaccgt       60

cccctcggta atggcgaatg ggaccc                                            86


<210>  387
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HDV ribozyme

<400>  387
gatggccggc atggtcccag cctcctcgct ggcgccggct gggcaacacc ttcgggtggc       60

gaatgggac                                                               69


<210>  388
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HDV ribozyme

<400>  388
ttttggccgg catggtccca gcctcctcgc tggcgccggc tgggcaacat gcttcggcat       60

ggcgaatggg accccggg                                                     78


<210>  389
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hatchet

<400>  389
cattcctcag aaaatgacaa acctgtgggg cgtaagtaga tcttcggatc tatgatcgtg       60

cagacgttaa aatcaggt                                                     78


<210>  390
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  env25 pistol ribozyme (with CUUCGG loop)

<400>  390
cgtggttagg gccacgttaa atagttgctt aagccctaag cgttgatctt cggatcaggt       60

gcaa                                                                    64


<210>  391
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HH15 Minimal Hammerhead ribozyme

<400>  391
gggagccccg ctgatgaggt cggggagacc gaaagggact tcggtcccta cggggctccc       60


<210>  392
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sTRSV WT viral Hammerhead ribozyme

<400>  392
cctgtcaccg gatgtgcttt ccggtctgat gagtccgtga ggacgaaaca gg               52


<210>  393
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hammerhead ribozyme

<400>  393
cgactactga tgagtccgtg aggacgaaac gagtaagctc gtctagtcgc gtgtagcgaa       60

gca                                                                     63


<210>  394
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hammerhead ribozyme, smaller scar

<400>  394
cgactactga tgagtccgtg aggacgaaac gagtaagctc gtctagtcg                   49


<210>  395
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hammerhead ribozyme, guide scaffold scar

<400>  395
ccagtactga tgagtccgtg aggacgaaac gagtaagctc gtctactggc gcttttatct       60

cat                                                                     63


<210>  396
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Twisted Sister 1

<400>  396
acccgcaagg ccgacggcat ccgccgccgc tggtgcaagt ccagccgccc cttcgggggc       60

gggcgctcat gggtaac                                                      77


<210>  397
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Env-9 Twister

<400>  397
ggcaataaag cggttacaag cccgcaaaaa tagcagagta atgtcgcgat agcgcggcat       60

taatgcagct ttattg                                                       76


<210>  398
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RBMX recruiting motif

<400>  398
ccacccccac caccaccccc acccccacca ccaccc                                 36


<210>  399
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  399
agtccctcaa gtccttccag                                                   20


<210>  400
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  400
agcagcagca gcagcagcag                                                   20


<210>  401
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  401
tcagccgccg ccgcaggcac                                                   20


<210>  402
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  402
agggtcgcca tggcggtctc                                                   20


<210>  403
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  403
tcagcttttc cagggtcgcc                                                   20


<210>  404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  404
agucccucaa guccuuccag                                                   20


<210>  405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  405
agcagcagca gcagcagcag                                                   20


<210>  406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  406
ucagccgccg ccgcaggcac                                                   20


<210>  407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  407
agggucgcca uggcggucuc                                                   20


<210>  408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  408
ucagcuuuuc cagggucgcc                                                   20


<210>  409
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  409
uucguugaaa agaaaaccuu accg                                              24


<210>  410
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  410
uucuuuucaa cgaaaagcag cccc                                              24


<210>  411
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  411
uucaacgaaa agcagccccc aagc                                              24


<210>  412
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  412
uuccuagcuu gaacuucccc uuua                                              24


<210>  413
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  413
uucaaauaca auguccagca caca                                              24


<210>  414
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  414
uuccugguaa uuuguguuug ugug                                              24


<210>  415
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  415
uucaucccag ugagaaagau caag                                              24


<210>  416
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  416
uucucacugg gaugaacuag cagc                                              24


<210>  417
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  417
uucaagcuag uaacgaugcu aacg                                              24


<210>  418
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  418
uucccgcagc uaggcuaaag aguc                                              24


<210>  419
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  419
uucuuugauu guguuucuua uuug                                              24


<210>  420
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  420
uucucaucaa auaagaaaca caau                                              24


<210>  421
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  421
uucuaaaaua caguauaccu ccuc                                              24


<210>  422
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  422
uucaaacaca gaggagguau acug                                              24


<210>  423
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  423
uucugauugu uaaucauaaa gucu                                              24


<210>  424
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  424
uucuagacuu uaugauuaac aauc                                              24


<210>  425
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  425
uuccucauug cacuuccaug uugg                                              24


<210>  426
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  426
uucauuuggg auauuugacc ugcg                                              24


<210>  427
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  427
uucugaagag cuacaacgca gguc                                              24


<210>  428
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  428
uucuuguucu cucuuuuucu uugg                                              24


<210>  429
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  429
uucaaaugga gaauacgggu aaca                                              24


<210>  430
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  430
uuccaaguag uaguuaguaa ucaa                                              24


<210>  431
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  431
uucacagcaa auaauuuugg aaag                                              24


<210>  432
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  432
uuccaaaauu auuugcugug aauu                                              24


<210>  433
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  433
uucuaauuca cagcaaauaa uuuu                                              24


<210>  434
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  434
uuccuaaacu ucuaauucac agca                                              24


<210>  435
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  435
uucauucuca aguuaguuuu agau                                              24


<210>  436
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  436
uucucaaguu aguuuuagau uaga                                              24


<210>  437
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  437
uucaguccuu ucugcccacc agca                                              24


<210>  438
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  438
uuucugccca ccagcacaug cuuu                                              24


<210>  439
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  439
uucugcccac cagcacaugc uuuc                                              24


<210>  440
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  440
uucuacuugu agauugauuu aggg                                              24


<210>  441
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  441
uucucccuaa aucaaucuac aagu                                              24


<210>  442
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  442
uuccuaguca gucucgccuu accu                                              24


<210>  443
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  443
uucuccugcu ccgccugcac caug                                              24


<210>  444
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  444
uucccuaaaa acaaaaacau ccau                                              24


<210>  445
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  445
uuuuagggaa ucagaggcaa ucau                                              24


<210>  446
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  446
uucuauuguc uguccccuua cccg                                              24


<210>  447
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  447
uucacucacu ugcuuuucua uugu                                              24


<210>  448
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  448
uucaugcugc caagggaugc ugac                                              24


<210>  449
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  449
uucuagcguu gaaguacugu cccc                                              24


<210>  450
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  450
uucuucuagc guugaaguac uguc                                              24


<210>  451
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  451
uuccucacug aggaugaaau ggca                                              24


<210>  452
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  452
uucauccuca gugaggaagg ugau                                              24


<210>  453
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  453
uucaucccac agugguuugc cuau                                              24


<210>  454
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  454
uuccauugcu cccagcauua uaau                                              24


<210>  455
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  455
uucucuuccc ccgagucccu uugg                                              24


<210>  456
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  456
uucccccgag ucccuuuggc uccc                                              24


<210>  457
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  457
uucuauccug uccccaaguu cauc                                              24


<210>  458
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  458
uucuggugau gacaauuuau uaau                                              24


<210>  459
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  459
uucuaguccc aaaucugggu gcua                                              24


<210>  460
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  460
uucuguacac acguguccuu gaca                                              24


<210>  461
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  461
uucagaaugc cucaucuggu caaa                                              24


<210>  462
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  462
uucccgcugc gccguuucug caua                                              24


<210>  463
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  463
uucugccagc gcaugugucc uuuc                                              24


<210>  464
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  464
uuccccuuga aaggacacau gcgc                                              24


<210>  465
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  465
uuccucaucg gagagcacac ccug                                              24


<210>  466
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  466
uucaguugcg uugauuugau uuuu                                              24


<210>  467
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  467
uucagagguu cgguggacac aggc                                              24


<210>  468
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  468
uucgguggac acaggcagcu gccc                                              24


<210>  469
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  469
uucugggugc uggagauauc augg                                              24


<210>  470
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  470
uucuaccaau uuucuauuuu ugga                                              24


<210>  471
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  471
uuccaccucu gaaaccccga aauu                                              24


<210>  472
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  472
uucucaaauu ucgggguuuc agag                                              24


<210>  473
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  473
uucgcuauga aggccuuuaa caaa                                              24


<210>  474
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  474
uucagguucg cuaugaaggc cuuu                                              24


<210>  475
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  475
uucauagcga accugaaguc aagc                                              24


<210>  476
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  476
uucccccugu uagcaaaaac gaag                                              24


<210>  477
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  477
uucguuuuug cuaacagggg gaaa                                              24


<210>  478
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  478
uucccauugg aucucucagc ccau                                              24


<210>  479
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  479
uuccggccaa aaucaaagca ucuu                                              24


<210>  480
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  480
uucucuaaca aaccccccuu cucu                                              24


<210>  481
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  481
uuccgugcug uucugaagau ccag                                              24


<210>  482
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  482
uucagaacag cacggaaaag uuug                                              24


<210>  483
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  483
uucuccgcuc agccuuggau guuc                                              24


<210>  484
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  484
uccgcucagc cuuggauguu cuuu                                              24


<210>  485
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  485
uuccugcauc agcuuuauuu guuc                                              24


<210>  486
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  486
uucuggccau uuugaggguu cuga                                              24


<210>  487
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  487
cucaaaaugg ccagaauucc cgau                                              24


<210>  488
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  488
uucaacucuu aucuugaaac caau                                              24


<210>  489
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  489
uucaagauaa gaguugaaau aauu                                              24


<210>  490
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  490
uuccucugug gcagagggga uggc                                              24


<210>  491
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  491
cucuguggca gaggggaugg cugc                                              24


<210>  492
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  492
uucucucgug gugacagguc acag                                              24


<210>  493
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  493
uucgcaguuu uugcuugagu ugua                                              24


<210>  494
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  494
uucagacccu aauccugcag cccc                                              24


<210>  495
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  495
uucucaugaa gcaaagcaag ccuc                                              24


<210>  496
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  496
uucaugagaa ccuagaccuu gcug                                              24


<210>  497
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  497
uucuugguuu ugacauggac gcga                                              24


<210>  498
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  498
uucucuuugu ucuguuguaa uuuu                                              24


<210>  499
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  499
uucauauccg ccuauaccau acaa                                              24


<210>  500
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  500
uucuaccuuc auauccgccu auac                                              24


<210>  501
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  501
uuccugagca auggcgugag aaac                                              24


<210>  502
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  502
uucucacgcc auugcucagg aaca                                              24


<210>  503
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  503
uucaucuacc gcaucaacac acua                                              24


<210>  504
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  504
uucaagaagc cugauaaaau cucu                                              24


<210>  505
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  505
uucugucagc gucacauaca ucag                                              24


<210>  506
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  506
uucacagcua ucuucucauc aaua                                              24


<210>  507
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  507
uucuucacag cuaucuucuc auca                                              24


<210>  508
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mutant HTT spacer sequence

<400>  508
uucuucucuu uguucuguug uaau                                              24


<210>  509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  509
aaagaaaaaa acauugcccu                                                   20


<210>  510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  510
uaaauugggu gugcuagccc                                                   20


<210>  511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  511
aguggggggg ccccuccaug                                                   20


<210>  512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  512
uuccauucau ccuauccaac                                                   20


<210>  513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  513
uauccaacua uucuacauua                                                   20


<210>  514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  514
aacuauucua cauuaauuac                                                   20


<210>  515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  515
auucagauca gucaaaaaau                                                   20


<210>  516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  516
gaauagauua agcacaagua                                                   20


<210>  517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  517
gucaaaaaau auccauucac                                                   20


<210>  518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  518
auucacuuuu gucuuccucc                                                   20


<210>  519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  519
auaucuaagu uuuuuuugca                                                   20


<210>  520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  520
aaguuuuuuu ugcaauccaa                                                   20


<210>  521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  521
aacugaaaaa agacaaaagu                                                   20


<210>  522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  522
uuucaccaaa ugggacucau                                                   20


<210>  523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  523
gaugacaguc cagugccuuc                                                   20


<210>  524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  524
gauuuuacau gagucccauu                                                   20


<210>  525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  525
cagcccugcu uccuccuggc                                                   20


<210>  526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  526
gcauaguuua aacguucaca                                                   20


<210>  527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  527
guuaaggcac ugagguguga                                                   20


<210>  528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  528
ccucacauca cagugcagca                                                   20


<210>  529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  529
cagugcagca caagugcacc                                                   20


<210>  530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  530
agacaacaaa uggggggcac                                                   20


<210>  531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  531
ccccccuggg gcgcaggcag                                                   20


<210>  532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  532
uucauccuca gggggaccug                                                   20


<210>  533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  533
ucagggggac cuguaaccag                                                   20


<210>  534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  534
gguuacaggu cccccugagg                                                   20


<210>  535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  535
acggggaugc cugaggcgua                                                   20


<210>  536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  536
ccguggaucu gguuacaggu                                                   20


<210>  537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  537
cagcuuccag uuccuccagc                                                   20


<210>  538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  538
cuguccaaga cucacaguaa                                                   20


<210>  539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  539
ucucugucca agacucacag                                                   20


<210>  540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  540
ccucacaugc ucccaacaau                                                   20


<210>  541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  541
ccaccugaca cuagggaaac                                                   20


<210>  542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  542
gcucaccauu auucaccuuu                                                   20


<210>  543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  543
gagagcuggu aagugacagc                                                   20


<210>  544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  544
gguauucugg gaauucuugg                                                   20


<210>  545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  545
cuccucuuaa ggucgaacaa                                                   20


<210>  546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  546
auuacgugaa gcucucgacu                                                   20


<210>  547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  547
cucagggcuc uccuucccug                                                   20


<210>  548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  548
cucccugcgc cgacucuguc                                                   20


<210>  549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  549
gcacucaggc uguggucagc                                                   20


<210>  550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  550
aggucaugcc accccuccca                                                   20


<210>  551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  551
ggaacacugg cuuuccagca                                                   20


<210>  552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  552
gcugaaaacg aauucaucag                                                   20


<210>  553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  553
guagccuggc uagaaguuau                                                   20


<210>  554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  554
cucaaauccc aagucccugg                                                   20


<210>  555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  555
caagucccug gaacaggguc                                                   20


<210>  556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  556
cccagaagua uacagcuggg                                                   20


<210>  557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  557
cugucaucgc cccucacccu                                                   20


<210>  558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  558
ccccucaccc ucagccacca                                                   20


<210>  559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  559
cugcacuucg ggaccaaaca                                                   20


<210>  560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  560
guuugguccc gaagugcaga                                                   20


<210>  561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  561
agaccuugcc ccacccccca                                                   20


<210>  562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  562
gccacuucgu uuccagggug                                                   20


<210>  563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  563
cuaaucuggg ccuggaaugu                                                   20


<210>  564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  564
gggccuggaa uguuuacagg                                                   20


<210>  565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  565
cucaguaagg cagauuuaua                                                   20


<210>  566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  566
gccuuacuga gugaugugua                                                   20


<210>  567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  567
acccagccag cauaacccac                                                   20


<210>  568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  568
uugaggagga auugacccuc                                                   20


<210>  569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  569
ugagugauau uaauaugcuc                                                   20


<210>  570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  570
cucaggauga auuuguguuu                                                   20


<210>  571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  571
ccaaagagca uauuaauauc                                                   20


<210>  572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  572
cucccagguc cagguaagug                                                   20


<210>  573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  573
auagaaaguc auaaccaagc                                                   20


<210>  574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  574
gaaacaaaag ucucagugcu                                                   20


<210>  575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  575
auaaagcagg acaagcugac                                                   20


<210>  576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  576
ugacuuugaa cacucccagg                                                   20


<210>  577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  577
uguaaguauu auccugacuu                                                   20


<210>  578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  578
gaacacuuua uaccaagaaa                                                   20


<210>  579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  579
uauugguguu uaaaagacug                                                   20


<210>  580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  580
gucuuuuaaa caccaauaug                                                   20


<210>  581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  581
ucacaccugg cuaauuuuug                                                   20


<210>  582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  582
cagcuacucg ggaggcuaag                                                   20


<210>  583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  583
uggcucacug caaccuccgc                                                   20


<210>  584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  584
cgccacugca cucaagccug                                                   20


<210>  585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  585
ugccacugcu cucuagccug                                                   20


<210>  586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  586
caccuuacug cagccuccaa                                                   20


<210>  587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  587
cuuaagcuca gggguuggag                                                   20


<210>  588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  588
uccugaguag cugagacuac                                                   20


<210>  589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  589
ccaccaccac ccgacccaaa                                                   20


<210>  590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  590
cagugagacc cugucucuac                                                   20


<210>  591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  591
uagugcuuug ggaggcugag                                                   20


<210>  592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  592
aaacaaaaca aagcuggcca                                                   20


<210>  593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  593
uauaaagguu aaccagacag                                                   20


<210>  594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  594
gcagucauug ggagacccgg                                                   20


<210>  595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  595
acuuuccagg guagcucccu                                                   20


<210>  596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  596
gcucucccuc uggccaccca                                                   20


<210>  597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  597
gagagaccag aaccuaggac                                                   20


<210>  598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  598
acuggucagu uugaucagug                                                   20


<210>  599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  599
aacugaccag uagaucugag                                                   20


<210>  600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  600
guggauuuau cucacacugu                                                   20


<210>  601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  601
acugaucaaa cugaccagua                                                   20


<210>  602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  602
cacacugucc ucaguguugu                                                   20


<210>  603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  603
aguccaaagc aguuauuuug                                                   20


<210>  604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  604
uucucuacuu auuuuugauu                                                   20


<210>  605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  605
aaaauaagua gagaaugauu                                                   20


<210>  606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  606
gcucagaggc agaauuccaa                                                   20


<210>  607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  607
guuugggagg ccucuaaugc                                                   20


<210>  608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  608
ucagugacua gcauuagagg                                                   20


<210>  609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  609
guagauggau cguguguuca                                                   20


<210>  610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  610
acagaugccc cuuauccuca                                                   20


<210>  611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  611
aucuacagau gccccuuauc                                                   20


<210>  612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  612
uguguucagg gugacccuag                                                   20


<210>  613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  613
auuuuauacu cuccugcagg                                                   20


<210>  614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  614
cuggauacca ggauccagag                                                   20


<210>  615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  615
agggauuccu auauuacagg                                                   20


<210>  616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  616
ugguauccag ggauuccuau                                                   20


<210>  617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  617
agagguagcc gucagaacau                                                   20


<210>  618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  618
gggaacccuc uaaacuuugu                                                   20


<210>  619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  619
uccuugcuca gccuucccag                                                   20


<210>  620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  620
cuugaacuca ggaguucaag                                                   20


<210>  621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  621
uaccgcauuu uucauuuccc                                                   20


<210>  622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  622
cauuugauua guuucccuca                                                   20


<210>  623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  623
aaugagauga acaaagucuc                                                   20


<210>  624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  624
cugcuguguc ccgaggugug                                                   20


<210>  625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  625
aagacacuca caccucggga                                                   20


<210>  626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  626
aguaaaaauc aaagacacuc                                                   20


<210>  627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  627
agaccacccg gcuaacacgg                                                   20


<210>  628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  628
ccugaccuug ugauccaccu                                                   20


<210>  629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  629
caaggucagg agaucgagac                                                   20


<210>  630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  630
accugccucg gccucccaaa                                                   20


<210>  631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  631
cagcacuuug ggaggccgag                                                   20


<210>  632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  632
caaaaaaaaa aaaacagugu                                                   20


<210>  633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  633
ggccauggca cuccagccug                                                   20


<210>  634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  634
cggcucccug aaccuccagg                                                   20


<210>  635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  635
ccugaaccug gagguucagg                                                   20


<210>  636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  636
cagcuacucg ggaggcugag                                                   20


<210>  637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  637
aggcguggug gcacaugccu                                                   20


<210>  638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  638
ggcguucaag accagcccga                                                   20


<210>  639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  639
caggugaucc guccgccuug                                                   20


<210>  640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  640
ccugagauca ggcguucaag                                                   20


<210>  641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  641
guccgccuug gccucccaaa                                                   20


<210>  642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  642
cagcacuuug ggaggccaag                                                   20


<210>  643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  643
cacuggccgg gcacaguggc                                                   20


<210>  644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  644
cugccucagc cucccaagca                                                   20


<210>  645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  645
uggcucacug caaccuccac                                                   20


<210>  646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  646
caaaaaauaa auaauuuuua                                                   20


<210>  647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  647
gggcugggug ggguggcuca                                                   20


<210>  648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  648
cagcacuuug ggaggccgaa                                                   20


<210>  649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  649
accagcuucg gccucccaaa                                                   20


<210>  650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  650
cuugagguug ggaguucaug                                                   20


<210>  651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  651
ggcuugucau gaacucccaa                                                   20


<210>  652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  652
acauagagaa accccaucuc                                                   20


<210>  653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  653
cuacuaaaaa gacaaaauua                                                   20


<210>  654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  654
uagcuacugg ggaaucugag                                                   20


<210>  655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  655
gaggcaggag aaucacuuga                                                   20


<210>  656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  656
cuugaaccca ggagggagag                                                   20


<210>  657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  657
caggucacug caaccucucc                                                   20


<210>  658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  658
ucucagguca cugcaaccuc                                                   20


<210>  659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  659
guugaucuuu uccuuuaugc                                                   20


<210>  660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  660
acagauucaa cuauauauau                                                   20


<210>  661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  661
uuuccuuuau gcuuuagugc                                                   20


<210>  662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  662
ucaugaccuu ggguaaaggg                                                   20


<210>  663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  663
aucaucuuuc acauuuaggu                                                   20


<210>  664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  664
ucuuucacau uuaggucuau                                                   20


<210>  665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  665
uucacauuua ggucuauaau                                                   20


<210>  666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  666
auucuuuaau uauagaccua                                                   20


<210>  667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  667
cacaccauac acaaaaauca                                                   20


<210>  668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  668
aguuguucug uauuaacuuc                                                   20


<210>  669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  669
ugguuauaaa uuuaguguau                                                   20


<210>  670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  670
uaccuugauu cuauauuccu                                                   20


<210>  671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  671
agguaugaua cacggacacu                                                   20


<210>  672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  672
uugagcggcc aguaccacac                                                   20


<210>  673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  673
uccugccacu gcauuccagc                                                   20


<210>  674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  674
ucccaccuca gccuccugag                                                   20


<210>  675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  675
cagcacuuug ggaggcuugg                                                   20


<210>  676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  676
uaguccguuu guguugcuau                                                   20


<210>  677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  677
agccucaggu auuccuuaua                                                   20


<210>  678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  678
ggugagagcc ucagguuuuu                                                   20


<210>  679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  679
ggacacacug gguccucuuc                                                   20


<210>  680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  680
ugucaucugg acacacuggg                                                   20


<210>  681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  681
cucuugcuuu uucucucauc                                                   20


<210>  682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  682
uuucaccuca gacuccugag                                                   20


<210>  683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  683
cuugagccca gaaguucgag                                                   20


<210>  684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  684
uccugccuca gucugccaag                                                   20


<210>  685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  685
cuugauagcc cggguggugg                                                   20


<210>  686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  686
agugauccuc cugccucagu                                                   20


<210>  687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  687
uggcucgcug caaccuccac                                                   20


<210>  688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  688
ugcuacugca guccagccua                                                   20


<210>  689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  689
uuuccuuccu uuucagugaa                                                   20


<210>  690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  690
ccucucagua gcacuucugc                                                   20


<210>  691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  691
uuguguuucu ucagaguggg                                                   20


<210>  692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  692
uaauggaagu gaugcaggaa                                                   20


<210>  693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  693
cuuccauuag gaugcaaaua                                                   20


<210>  694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  694
cuuucucuuu cuuuccugca                                                   20


<210>  695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  695
ucacuuucuc uuucuuuccu                                                   20


<210>  696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  696
gugguccuca aguggcgaca                                                   20


<210>  697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  697
gcagaccugc gccugugccc                                                   20


<210>  698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  698
uuuggaaaag cacuuggcag                                                   20


<210>  699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  699
uccuuuauac uccucagcac                                                   20


<210>  700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  700
cgagcuccgu caaugcggag                                                   20


<210>  701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  701
ccacaucuac uccacugcuc                                                   20


<210>  702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  702
acuccacugc uccccuuccu                                                   20


<210>  703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  703
uuaggcucag ggaccuuggc                                                   20


<210>  704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  704
uuugacuuac auggaccaua                                                   20


<210>  705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  705
gccuggugac uuagcuuuau                                                   20


<210>  706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  706
acauuguauu augggaagga                                                   20


<210>  707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  707
ucuccuuccc auaauacaau                                                   20


<210>  708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  708
gacccaagga cagccaaacc                                                   20


<210>  709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  709
ccugugcucc ccuggcagca                                                   20


<210>  710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  710
ccaucaccug ugcuccccug                                                   20


<210>  711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  711
aucaccauca ccugugcucc                                                   20


<210>  712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  712
gacccucauc caucaccauc                                                   20


<210>  713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  713
ucagacccuc auccaucacc                                                   20


<210>  714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  714
gcagaggugu gggugacuug                                                   20


<210>  715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  715
aaaguagcca uuugcacacc                                                   20


<210>  716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  716
caaaauuaag ugaccugaag                                                   20


<210>  717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  717
caguaaccag ucauuuugca                                                   20


<210>  718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  718
cugaaggucc ugaaaaauca                                                   20


<210>  719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  719
aaggccuacu aacuucucac                                                   20


<210>  720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  720
acuaagguca aauaaaaagu                                                   20


<210>  721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  721
uuaaaguaaa guuaaucuac                                                   20


<210>  722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  722
acaaaauacu ucaagucucu                                                   20


<210>  723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  723
cugcucuguc augggacagc                                                   20


<210>  724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  724
agacauguuc ugaggcuggc                                                   20


<210>  725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  725
gagccagccu cagaacaugu                                                   20


<210>  726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  726
agaagaaaac aaauaucuga                                                   20


<210>  727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  727
aaacaaauag uaauuauauu                                                   20


<210>  728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  728
uauuuacauc uguagaacca                                                   20


<210>  729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  729
guagaaccac uggccauuua                                                   20


<210>  730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  730
uuaaaaacag uugcaguuuu                                                   20


<210>  731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  731
uucagaguuc auucuuuaaa                                                   20


<210>  732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  732
uuuuaaauag cuaauauaac                                                   20


<210>  733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  733
gucacuguug aauuuuauug                                                   20


<210>  734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  734
agcaauuuau aauuucaagg                                                   20


<210>  735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  735
uacagaguaa auaucuagca                                                   20


<210>  736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  736
cagagccuua aauacuuaag                                                   20


<210>  737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  737
ugaguuaggc acaaaauuac                                                   20


<210>  738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  738
uaucaugagu uaggcacaaa                                                   20


<210>  739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  739
cuuuguaacc acugagaagg                                                   20


<210>  740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  740
uuuauuagcu accugcacuc                                                   20


<210>  741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  741
uguauaggcu gggcuuggug                                                   20


<210>  742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  742
cagcacuuug ggaggccgag                                                   20


<210>  743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  743
gccuaccucg gccucccaaa                                                   20


<210>  744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  744
cgaggucagg aauuugagau                                                   20


<210>  745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  745
caaauuccug accucgugau                                                   20


<210>  746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  746
gccugaccga cgugaugaaa                                                   20


<210>  747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  747
cgucggucag gcugaucuca                                                   20


<210>  748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  748
cuacuaaaaa uacaaaaacu                                                   20


<210>  749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  749
cagcuacuca ggaggcugag                                                   20


<210>  750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  750
aggaggcgga gguugcaaug                                                   20


<210>  751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  751
cagcucauug caaccuccgc                                                   20


<210>  752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  752
cgccacugca cuccagccug                                                   20


<210>  753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  753
uuuucuuucu uucuuuuuuu                                                   20


<210>  754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  754
uauauaaaaa ugcagaaaau                                                   20


<210>  755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  755
cagcacuuug ggaggccgag                                                   20


<210>  756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  756
gcccgccucg gccucccaaa                                                   20


<210>  757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  757
cgaggucagg agaucgagac                                                   20


<210>  758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  758
ccugaccucg ugaucugccc                                                   20


<210>  759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  759
agaccauccu ggccaacgug                                                   20


<210>  760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  760
uggccaacgu ggugaaaccc                                                   20


<210>  761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  761
uccugccuca gccucccaag                                                   20


<210>  762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  762
uuugaacucg ggaggcagag                                                   20


<210>  763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  763
uggcucacug caaccucugc                                                   20


<210>  764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  764
caaaaaaaaa aaacaaaaaa                                                   20


<210>  765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  765
caauuuucug uuuuuuaauu                                                   20


<210>  766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  766
auaauacaca cuuugucuug                                                   20


<210>  767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  767
ucccauuaga cacucaacau                                                   20


<210>  768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  768
uucacauguc caucuuccca                                                   20


<210>  769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  769
uauauucauu auacuacaaa                                                   20


<210>  770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  770
cagcauugug agaggccgag                                                   20


<210>  771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  771
acccgccucg gccucucaca                                                   20


<210>  772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  772
cgaggucagg agaucgagac                                                   20


<210>  773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  773
ccugaccucg ugauccaccc                                                   20


<210>  774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  774
agaccauccu ggcuaacaug                                                   20


<210>  775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  775
uggcuaacau ggugaaaccc                                                   20


<210>  776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  776
cagcuacuug guaggcugag                                                   20


<210>  777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  777
cuugaaccug ggagguggag                                                   20


<210>  778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  778
cggcucagug caaccuccac                                                   20


<210>  779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  779
ugccacuaca ccccagccug                                                   20


<210>  780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  780
auacguguca cacgcagcua                                                   20


<210>  781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  781
cuucaaaccc cacuauggua                                                   20


<210>  782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  782
ccccgccuuu ccuuuacaag                                                   20


<210>  783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  783
cuuccugccu ucauacuugc                                                   20


<210>  784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  784
cccacuugaa acuccuuaca                                                   20


<210>  785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  785
ugcuugaucc uuugcuaagg                                                   20


<210>  786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  786
agcaggauac accaggcccu                                                   20


<210>  787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  787
uuugcuaagg acuugaucuu                                                   20


<210>  788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  788
aguccuuagc aaaggaucaa                                                   20


<210>  789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  789
uuuuaggcag caggaacaau                                                   20


<210>  790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  790
aaggguuuaa ggcagagaau                                                   20


<210>  791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  791
ccugucaaaa cccccucaca                                                   20


<210>  792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  792
ggguugugcu gcuguuaccc                                                   20


<210>  793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  793
ucucggguaa cagcagcaca                                                   20


<210>  794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  794
uaggguaaaa acacaguaaa                                                   20


<210>  795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  795
guaaaguauu uuuaguaaau                                                   20


<210>  796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  796
ggguuuucau guuuaauuug                                                   20


<210>  797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  797
uaauagcauu uguuuucuug                                                   20


<210>  798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  798
uaaaagacau uaaaucauaa                                                   20


<210>  799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  799
guuuauucag aaaagguaaa                                                   20


<210>  800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  800
uagaugguag aacucagcug                                                   20


<210>  801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  801
augauguauu uuaccuuuuc                                                   20


<210>  802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  802
uagccauaug uccguauucu                                                   20


<210>  803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  803
uggucccuua cauggauaua                                                   20


<210>  804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  804
auguaaggga ccaagauaac                                                   20


<210>  805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  805
auguguuugu aggauuuggg                                                   20


<210>  806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  806
uacaaacaca uagaugaaau                                                   20


<210>  807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  807
cccaaauccu acaaacacau                                                   20


<210>  808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  808
ucccccaaau ccuacaaaca                                                   20


<210>  809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  809
caaaaaaaaa aauuauauau                                                   20


<210>  810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  810
cgccacugca uuccagccug                                                   20


<210>  811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  811
gcuugccgca accuccgccu                                                   20


<210>  812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  812
cuugaaccca ugaggcggag                                                   20


<210>  813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  813
cagcuacuca agcugaggca                                                   20


<210>  814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  814
guaaucccag cuacucaagc                                                   20


<210>  815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  815
agaggucagg aguucaagac                                                   20


<210>  816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  816
gccugccucg gccucacaga                                                   20


<210>  817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  817
caacacucug ugaggccgag                                                   20


<210>  818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  818
auguaacuag auuucugcuu                                                   20


<210>  819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  819
aguuacauug auauuuuuaa                                                   20


<210>  820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  820
acuucuaguu acuaccucuu                                                   20


<210>  821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  821
uccugucuca aacagugaaa                                                   20


<210>  822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  822
cuguccugcc ugccuguggg                                                   20


<210>  823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  823
cugagagaag aagaauaacc                                                   20


<210>  824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  824
ucagacucgg ucuggguagc                                                   20


<210>  825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  825
ccuugauuga ggaggcugag                                                   20


<210>  826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  826
aggagauccu cagacucggu                                                   20


<210>  827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  827
uacaaccugc aggacccugg                                                   20


<210>  828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  828
uccuaagcug ccacccaggg                                                   20


<210>  829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  829
gaacgccuuu ccucuuaccc                                                   20


<210>  830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  830
gagcuucguc augggccaua                                                   20


<210>  831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  831
acuucccuuc cugcagcccu                                                   20


<210>  832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  832
gcaguucagg agccagacag                                                   20


<210>  833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  833
caucucucuc ugcacgcagc                                                   20


<210>  834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  834
cucucugcac gcagccucag                                                   20


<210>  835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  835
cuccuucugc ucuugucagc                                                   20


<210>  836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  836
guacccuuua acccggugga                                                   20


<210>  837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  837
ucuuugcugu uauguuuuuc                                                   20


<210>  838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  838
cuauuuaauu aguuaauuuu                                                   20


<210>  839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  839
caugcucagg gacuggucca                                                   20


<210>  840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  840
uggaugacug gugaauguac                                                   20


<210>  841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  841
aggauuuacu gagcccauca                                                   20


<210>  842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  842
uaauguuaag agccagaaau                                                   20


<210>  843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  843
cauucuguaa uuaaaagggc                                                   20


<210>  844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  844
gaccuuucug gcuugcccuu                                                   20


<210>  845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  845
cuggcagaac agccauaccc                                                   20


<210>  846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  846
cuuuuccuca ggucuuagaa                                                   20


<210>  847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  847
gugugccuuu uuuuuuuuuu                                                   20


<210>  848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  848
caaaagccua aaugacgaca                                                   20


<210>  849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  849
auguauuuuu ccauaccaac                                                   20


<210>  850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  850
ugagcugaau guuuggggca                                                   20


<210>  851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  851
acaggguugu gaguuuuccc                                                   20


<210>  852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  852
aaacugcuga cuccuguuac                                                   20


<210>  853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  853
cugguucaug gaaacaugug                                                   20


<210>  854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  854
uuugagucuu gcugguauug                                                   20


<210>  855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  855
cuaauucauu cauuuauaca                                                   20


<210>  856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  856
guuauguaca guggguccuu                                                   20


<210>  857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  857
caccaccggu auucaaaagg                                                   20


<210>  858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  858
ccacccagaa gcuucuccaa                                                   20


<210>  859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  859
uaagacgggu ccuucacaca                                                   20


<210>  860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  860
acccaauccu aagacggguc                                                   20


<210>  861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  861
ugugucuccc ccgacacaca                                                   20


<210>  862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  862
cgccacugca uuccagccug                                                   20


<210>  863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  863
uggcucacug caaccuccac                                                   20


<210>  864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  864
uuugaaccug gaagguggag                                                   20


<210>  865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  865
cagcuacuca ggaggcugac                                                   20


<210>  866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  866
agccuggcca acauggugaa                                                   20


<210>  867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  867
ugccacugca cucuagccug                                                   20


<210>  868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  868
cagcucacua cagccucgac                                                   20


<210>  869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  869
ucucaccuca gccucccuag                                                   20


<210>  870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  870
aacuauuagc caggcauagu                                                   20


<210>  871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  871
uuugagcuca gagguuugag                                                   20


<210>  872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  872
ucucaccucu gccuccccag                                                   20


<210>  873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  873
caccucugcc uccccaggug                                                   20


<210>  874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  874
cagcaccugg ggaggcagag                                                   20


<210>  875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  875
caggcguaag ccacugugcc                                                   20


<210>  876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  876
gaaaaaaaau aaaauuagcc                                                   20


<210>  877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  877
uuugagaggu uuuaagguau                                                   20


<210>  878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  878
ugccuuuucc uccuaccucu                                                   20


<210>  879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  879
gcauuuucaa auagguccua                                                   20


<210>  880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  880
ggugauaaga gaugagcuca                                                   20


<210>  881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  881
ccugauguaa auaaacaucu                                                   20


<210>  882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  882
cuuaucaccu gauguaaaua                                                   20


<210>  883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  883
uuacugcugg gccuggaagg                                                   20


<210>  884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  884
aaggcccaga cgcccuucca                                                   20


<210>  885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  885
gcucccuguu uaucuugaau                                                   20


<210>  886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  886
ugaaucugga auuuggacag                                                   20


<210>  887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  887
ggaauuugga cagccgaccu                                                   20


<210>  888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  888
uugaggucgg cuguccaaau                                                   20


<210>  889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  889
gcagacacac uuaagccaga                                                   20


<210>  890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  890
ugaaucugag cccuggugug                                                   20


<210>  891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  891
gagcccuggu gugcagaugc                                                   20


<210>  892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  892
gcacaccagg gcucagauuc                                                   20


<210>  893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  893
ugggcggccc caccccugcc                                                   20


<210>  894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  894
ggaccacggg gcuggggggg                                                   20


<210>  895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  895
uggagguccg agcugggcgu                                                   20


<210>  896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  896
aaacuucccu cugcagcggc                                                   20


<210>  897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  897
gcgccagugg gcggcuuuuc                                                   20


<210>  898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  898
gucacucaca cuucagugug                                                   20


<210>  899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  899
cagggguggc agagggacug                                                   20


<210>  900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  900
ccucucugug ccucaguuug                                                   20


<210>  901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  901
guugacacug gggacagcug                                                   20


<210>  902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  902
aggcaggcug uccaccccag                                                   20


<210>  903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  903
ccggcccaug ucaccugcaa                                                   20


<210>  904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  904
ucacucccuu gcagcccucg                                                   20


<210>  905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  905
ccucucccug ccacccgcca                                                   20


<210>  906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  906
gucuuccuuc ugccugcccc                                                   20


<210>  907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  907
ggugagaggg gugcugacag                                                   20


<210>  908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  908
uggaggccug gggacucccu                                                   20


<210>  909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  909
ugggggagcc caccaaggag                                                   20


<210>  910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  910
cuggggggug gggagcucca                                                   20


<210>  911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  911
cgucucucug ggccccugga                                                   20


<210>  912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  912
uggcugaguu ugcgcccuuc                                                   20


<210>  913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  913
ugggugugaa cucagaugcc                                                   20


<210>  914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  914
gaguucacac ccaagauccu                                                   20


<210>  915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  915
cacagcugga aacugguggc                                                   20


<210>  916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  916
uggccaggag gcuucccccu                                                   20


<210>  917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  917
augaccugag ggcugugaag                                                   20


<210>  918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  918
ccccuacgga cacucauagc                                                   20


<210>  919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  919
ggaguggcca guguugggca                                                   20


<210>  920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  920
ugaggucaag agaggacaga                                                   20


<210>  921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  921
gcccaccucc caaagugcug                                                   20


<210>  922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  922
cagcacuuug ggaggugggc                                                   20


<210>  923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  923
cugugcagcc ugggugggug                                                   20


<210>  924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  924
cuccuccuga cggcccaccc                                                   20


<210>  925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  925
gagccgggcg ggcagccaug                                                   20


<210>  926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  926
uuccuccagg auaggcggcu                                                   20


<210>  927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  927
uggaggaagg auuccagggu                                                   20


<210>  928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  928
ugucuacccu cccgugcaca                                                   20


<210>  929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  929
ggaaacugag ggucaggaag                                                   20


<210>  930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  930
gcaaaacggg augacagaag                                                   20


<210>  931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  931
cguuuugcag aucaggaaac                                                   20


<210>  932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  932
agcagcgugg uccagagcca                                                   20


<210>  933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  933
uucaagggug acgcgagaga                                                   20


<210>  934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  934
ggggccggga aaccaagcag                                                   20


<210>  935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  935
cagaucgugc uggaacugcu                                                   20


<210>  936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  936
gugaucgggg gccgggaaac                                                   20


<210>  937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  937
ugcuggaacu gcuggcccca                                                   20


<210>  938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  938
augaagaaag ggccagucac                                                   20


<210>  939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  939
gguccaucuu ugucagcugg                                                   20


<210>  940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  940
uugucagcug gccucuggga                                                   20


<210>  941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  941
ccccaggcaa cugcuccagg                                                   20


<210>  942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  942
gaggagcccu gagggguugg                                                   20


<210>  943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  943
auacccccau cccuguagcu                                                   20


<210>  944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  944
cuguagcuga gcugauucca                                                   20


<210>  945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  945
gcucagcuac agggaugggg                                                   20


<210>  946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  946
gauguuuacu gcgcuccugc                                                   20


<210>  947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  947
gauucacaag gaagcagagg                                                   20


<210>  948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  948
ggccucccau gaguuagacc                                                   20


<210>  949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  949
ccaggcccga gcuagggccu                                                   20


<210>  950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  950
aggcugaagg aacuccccca                                                   20


<210>  951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  951
agggguguug uaaucuagug                                                   20


<210>  952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  952
agugaugcuc uucuguggca                                                   20


<210>  953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  953
cuagauuaca acaccccugg                                                   20


<210>  954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  954
cuucccaccu uguccagggg                                                   20


<210>  955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  955
ggggucauuc ugggagccug                                                   20


<210>  956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  956
auggugaccu guccgccugc                                                   20


<210>  957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  957
gagccuaaug ugccagucag                                                   20


<210>  958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  958
gauaauauca gacuguugug                                                   20


<210>  959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  959
gauuggaaac uccaccaacu                                                   20


<210>  960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  960
gacuguugug cuuuggucuc                                                   20


<210>  961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  961
cagccuccuc ccuucccccu                                                   20


<210>  962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  962
accgcugcca gggccaccga                                                   20


<210>  963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  963
caagccaaca cacguuuagg                                                   20


<210>  964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  964
ggccuuuugc uuggacuugc                                                   20


<210>  965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  965
uuccccauug cccuccuaau                                                   20


<210>  966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  966
agaaaagcug gccugggagc                                                   20


<210>  967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  967
ccucucucgg aaacgccccu                                                   20


<210>  968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  968
gcggaccgcc ucgggcagcg                                                   20


<210>  969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  969
gcccagccau cagcggaccg                                                   20


<210>  970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  970
gccugccagg ccaggcccca                                                   20


<210>  971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  971
guggucagca gagugaguuu                                                   20


<210>  972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  972
uccccucugc ccuggucaaa                                                   20


<210>  973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  973
cccgagcugg gggaagugac                                                   20


<210>  974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  974
ccucuugugg ccucaggcgu                                                   20


<210>  975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  975
uccgccuucu cugggcaggg                                                   20


<210>  976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  976
caugaggcug cacuuccugu                                                   20


<210>  977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  977
agcugcuggg gcggggugug                                                   20


<210>  978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  978
aggccuccgg gcugauuagg                                                   20


<210>  979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  979
gcccggaggc cucgaugacc                                                   20


<210>  980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  980
cugaaaugcc uuccccucgg                                                   20


<210>  981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  981
caccucauua ggcagcugca                                                   20


<210>  982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  982
ugggguccug ggugcuggcu                                                   20


<210>  983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  983
cagagagccc cugccccaag                                                   20


<210>  984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  984
accuucccau uuucuugagg                                                   20


<210>  985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  985
ucaagaaaau gggaagguug                                                   20


<210>  986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  986
cccuccuggu cacauccuca                                                   20


<210>  987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  987
ucuuccuucc ccagcaacuu                                                   20


<210>  988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  988
ucugcagagg uggggguugg                                                   20


<210>  989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  989
agcgggccuu gccccaugcc                                                   20


<210>  990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  990
aggggacagc uauuccaggg                                                   20


<210>  991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  991
uuggugcugc cuuuucccag                                                   20


<210>  992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  992
gugaggcgcc ccuggcaucu                                                   20


<210>  993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  993
ccccgggggg gccuccuuga                                                   20


<210>  994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  994
uggucacguc accuccucca                                                   20


<210>  995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  995
ccuguagccc cugugcaggg                                                   20


<210>  996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  996
cagcagucug cugcucccuc                                                   20


<210>  997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  997
ccaagucacu ccugaggcug                                                   20


<210>  998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  998
gacagggagg uggcacagcc                                                   20


<210>  999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  999
gcccgggggg ggggcgguca                                                   20


<210>  1000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1000
ccagggagca guaagggcau                                                   20


<210>  1001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1001
gggucuccuc cucuccgccc                                                   20


<210>  1002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1002
agacuccacc ccugccuguc                                                   20


<210>  1003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1003
uguccccugc ccgggccccg                                                   20


<210>  1004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1004
cccuuccccu guccggccag                                                   20


<210>  1005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1005
gggugggaga gcaggccaca                                                   20


<210>  1006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1006
gggaaaaaaa cccauguuag                                                   20


<210>  1007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1007
cagcacuuug ggaggccaag                                                   20


<210>  1008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1008
acccgccuug gccucccaaa                                                   20


<210>  1009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1009
cagcuacucg ggaggcugag                                                   20


<210>  1010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1010
uugcucacuc caaccucugc                                                   20


<210>  1011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1011
ggucucucug ucacccaggc                                                   20


<210>  1012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1012
caaaaaaaaa ggggccgggc                                                   20


<210>  1013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1013
cagcacuuug ggaggccgag                                                   20


<210>  1014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1014
gccggccucg gccucccaaa                                                   20


<210>  1015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1015
ccugagguca ggaguucaag                                                   20


<210>  1016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1016
cagcuauagg aggcugaggc                                                   20


<210>  1017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1017
uggcucauug caaccucugu                                                   20


<210>  1018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1018
ugccacugca uucuagccug                                                   20


<210>  1019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1019
auauacacac acacacguaa                                                   20


<210>  1020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1020
uuuuucccua acguuacgug                                                   20


<210>  1021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1021
cagcgaaugc auuaaggcag                                                   20


<210>  1022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1022
gucagcgggu gccacaggcu                                                   20


<210>  1023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1023
uggcuccucu gugcaccacu                                                   20


<210>  1024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1024
ggacaagcuc cugggucagg                                                   20


<210>  1025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1025
ccgugguacu uuucguaccg                                                   20


<210>  1026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1026
ugguggcucc ugaccucugc                                                   20


<210>  1027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1027
ccacucuguu cccuuguuau                                                   20


<210>  1028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1028
cgcccuggug cugggauccg                                                   20


<210>  1029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1029
cagcaccagg gcgagauaac                                                   20


<210>  1030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1030
gggauaagca gggugcuguc                                                   20


<210>  1031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1031
cggaucccag caccagggcg                                                   20


<210>  1032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1032
cagggaaggu cugagaugcu                                                   20


<210>  1033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1033
cagaccuucc cugggaugag                                                   20


<210>  1034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1034
caugcuuggc uaacucaugu                                                   20


<210>  1035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1035
uccacaugag uuagccaagc                                                   20


<210>  1036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1036
gccagcgucc ugggagcaau                                                   20


<210>  1037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1037
guuccaccca gacacguuga                                                   20


<210>  1038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1038
uugugacauc uguuccaccc                                                   20


<210>  1039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1039
guuagggagg cagccaccuc                                                   20


<210>  1040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1040
aagcuacugu cacccucugu                                                   20


<210>  1041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1041
cgggugcagg guguggcguu                                                   20


<210>  1042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1042
ggcacagggg aggcacucag                                                   20


<210>  1043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1043
gagucucugc ggaugcgugg                                                   20


<210>  1044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1044
gcagagacuc ggaugaggaa                                                   20


<210>  1045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1045
caagagcccc uggggaggcu                                                   20


<210>  1046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1046
guuuaaaaca gaagcagcuc                                                   20


<210>  1047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1047
ggagaacaaa acgagcaguu                                                   20


<210>  1048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1048
ccaacugcuc guuuuguucu                                                   20


<210>  1049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1049
caagagguga cugugggcag                                                   20


<210>  1050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1050
caggaggguc ugguuggcgg                                                   20


<210>  1051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1051
agaggaagca gaagcagagg                                                   20


<210>  1052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1052
gccgggcacc uuccucaucu                                                   20


<210>  1053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1053
gcuguggccg ggacacccca                                                   20


<210>  1054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1054
gcucagugac ugcugcugcc                                                   20


<210>  1055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1055
augaggaugc uggggccggg                                                   20


<210>  1056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1056
auaggcaagg gcagcagcag                                                   20


<210>  1057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1057
ucaucgauag gcaagggcag                                                   20


<210>  1058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1058
cgggggaccc cuggcugcag                                                   20


<210>  1059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1059
ggccagcccc aggcacccca                                                   20


<210>  1060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1060
cugcaugucc gucccccaug                                                   20


<210>  1061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1061
cuccccacag aacugguguc                                                   20


<210>  1062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1062
gccccucccc ugacaccagu                                                   20


<210>  1063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1063
gcaggcccug ggccuucucc                                                   20


<210>  1064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1064
agaccacacu ccccugggcu                                                   20


<210>  1065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1065
ccuccuccug gccuguggcc                                                   20


<210>  1066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1066
ggacucugga gaauuuuuuc                                                   20


<210>  1067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1067
cuugagaaaa aauucuccag                                                   20


<210>  1068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1068
ugagccgccu cugcugcuug                                                   20


<210>  1069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1069
caagaaccuu uccuggggac                                                   20


<210>  1070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1070
ggagauguga gaacauugca                                                   20


<210>  1071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1071
ccggaugccc cacugggccu                                                   20


<210>  1072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1072
accaacagcu uggccuugcu                                                   20


<210>  1073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1073
uucagagcuc agagugaaaa                                                   20


<210>  1074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1074
guuugucugu cuguccuucu                                                   20


<210>  1075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1075
gggccuugga gauucagugg                                                   20


<210>  1076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1076
ccaaggccca gaugggcacc                                                   20


<210>  1077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1077
ccaagucaau ggcacaguuc                                                   20


<210>  1078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1078
agaaccuugc ccucuucucu                                                   20


<210>  1079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1079
ucaaaggaug agggagcguu                                                   20


<210>  1080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1080
uuugaggaug gaaccaucua                                                   20


<210>  1081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1081
ugguaccugc agucaccucc                                                   20


<210>  1082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1082
acguggacag ggaaccaacc                                                   20


<210>  1083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1083
agacaugaac auuaggaggu                                                   20


<210>  1084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1084
aacaugagca cacagugaca                                                   20


<210>  1085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1085
ugccagggug cggggcacac                                                   20


<210>  1086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1086
ggcagugugc cccgcacccu                                                   20


<210>  1087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1087
ucagaaaccu ggugcauagu                                                   20


<210>  1088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1088
gaaaccuggu gcauaguuua                                                   20


<210>  1089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1089
cgcgcccuca ccugaagcgg                                                   20


<210>  1090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1090
aggaggugcc cgucagccca                                                   20


<210>  1091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1091
cccagccccu gcugcccauc                                                   20


<210>  1092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1092
gauccccugc cagggcaggg                                                   20


<210>  1093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1093
gaugggcagc aggggcuggg                                                   20


<210>  1094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1094
ccugccaggg cagggccacu                                                   20


<210>  1095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1095
gcuggggacg uucucugccc                                                   20


<210>  1096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1096
acccuggcgg ggaaguugcu                                                   20


<210>  1097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1097
gccgggcaua ggcacccugg                                                   20


<210>  1098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1098
agggugccua ugcccggcgg                                                   20


<210>  1099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1099
gccucaccau ggccaccauc                                                   20


<210>  1100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1100
uccccugcug uaggcuggga                                                   20


<210>  1101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1101
ccaggaagcc uuggcagcca                                                   20


<210>  1102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1102
ggcgacggcc ugcugucucc                                                   20


<210>  1103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1103
gcucagcccc cuggcccugc                                                   20


<210>  1104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1104
gccgcaucac ggaaccccag                                                   20


<210>  1105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1105
cggaacccca gggcgauaga                                                   20


<210>  1106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1106
cccugggguu ccgugaugcg                                                   20


<210>  1107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1107
ccacaggcgc ccucuaucgc                                                   20


<210>  1108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1108
ggggcuggca cacaggggca                                                   20


<210>  1109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1109
cuauggaauc aagccuccag                                                   20


<210>  1110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1110
agccuccagc cccuaggccu                                                   20


<210>  1111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1111
ucugcuuccu gccagagacg                                                   20


<210>  1112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1112
uugcugaccu gggcucgccu                                                   20


<210>  1113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1113
gcaaagggaa cgucagccuc                                                   20


<210>  1114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1114
gccuggaggc caggaaggcc                                                   20


<210>  1115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1115
gcccaggggc aggggccaag                                                   20


<210>  1116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1116
gagggccacu ugcguucuca                                                   20


<210>  1117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1117
uggagggggu ucucggggga                                                   20


<210>  1118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1118
cauccuggag gggguucucg                                                   20


<210>  1119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1119
ccgggcgccu ccccaagcag                                                   20


<210>  1120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1120
gucucucagg ucucauuggc                                                   20


<210>  1121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1121
uggggcugcc uggcaccaug                                                   20


<210>  1122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1122
cuccauuggg gcccccucgg                                                   20


<210>  1123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1123
uuccucaucu cuccauuggg                                                   20


<210>  1124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1124
gaacgugaca cgcggaggca                                                   20


<210>  1125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1125
cuugccuccg cgugucacgu                                                   20


<210>  1126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1126
ugcccagaag ccaggacaug                                                   20


<210>  1127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1127
cgauggcggu ggcaaaccag                                                   20


<210>  1128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1128
ggaugccagu ggagaagagg                                                   20


<210>  1129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1129
ccuaggaccc ccucuauggc                                                   20


<210>  1130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1130
cgauaagggc uggggagguc                                                   20


<210>  1131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1131
ugauuccuca uccccuagga                                                   20


<210>  1132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1132
gaccucccca gcccuuaucg                                                   20


<210>  1133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1133
accagcagcc gccggagcgc                                                   20


<210>  1134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1134
cauggugggc ugcucugacc                                                   20


<210>  1135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1135
gccccuuuag ggugcucgcc                                                   20


<210>  1136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1136
cgcaggccag aacggccccu                                                   20


<210>  1137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1137
ccgaagccug cguuuccugc                                                   20


<210>  1138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1138
cggaccuggc cccaccccac                                                   20


<210>  1139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1139
ggguuccccg cggcuucaag                                                   20


<210>  1140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1140
cgaucccgau cccgaucccg                                                   20


<210>  1141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1141
ggauccgggu uccccgcggc                                                   20


<210>  1142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1142
cgaucccgau cccgauccca                                                   20


<210>  1143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1143
ggaucgggau ccggguuccc                                                   20


<210>  1144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1144
cgaucccgau cccaacccca                                                   20


<210>  1145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1145
ggaucgggau cgggauccgg                                                   20


<210>  1146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1146
cgaucccaac cccaacccca                                                   20


<210>  1147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1147
ggaucgggau cgggaucggg                                                   20


<210>  1148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1148
caaccccaac cccagccccg                                                   20


<210>  1149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1149
cggggcgcgg gccggggcug                                                   20


<210>  1150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1150
cgcgugcguc ccggucccgc                                                   20


<210>  1151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1151
cugcacguuc ucuuccggcc                                                   20


<210>  1152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1152
ucugcgcccu gcgggccugg                                                   20


<210>  1153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1153
uucccccuca gccgccuguc                                                   20


<210>  1154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1154
gcaagcauuu uagaaggugg                                                   20


<210>  1155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1155
cacguggccg acccuaacca                                                   20


<210>  1156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1156
gguuaggguc ggccacguga                                                   20


<210>  1157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1157
gguggcacac auaccgccuu                                                   20


<210>  1158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1158
auuaggaaga gguggggcuu                                                   20


<210>  1159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1159
cuaugaaacu gccauugcaa                                                   20


<210>  1160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1160
cacugucggc aaauuuugca                                                   20


<210>  1161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1161
uuguuuuaaa cuaaguuccu                                                   20


<210>  1162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1162
ucuuuguuuu aaacuaaguu                                                   20


<210>  1163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1163
ccaggaaagg uuuccuuugg                                                   20


<210>  1164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1164
guugguccca caaaagcagg                                                   20


<210>  1165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1165
uguggcuaau cuguuggucc                                                   20


<210>  1166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1166
uguagccucc cgcugcguga                                                   20


<210>  1167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1167
ccaggagcag uuuggggagg                                                   20


<210>  1168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1168
ccaucguaaa gccuaagauc                                                   20


<210>  1169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1169
uaaagccuaa gaucagcacu                                                   20


<210>  1170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1170
uaggcuuuac gauggugaug                                                   20


<210>  1171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1171
gcacuuggug ggucaccugg                                                   20


<210>  1172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1172
gauguugugg cacccaggaa                                                   20


<210>  1173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1173
gaugagccug gguggugcca                                                   20


<210>  1174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1174
cagggagucg aagcuguuuu                                                   20


<210>  1175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1175
cugaccugac caauggguac                                                   20


<210>  1176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1176
uuaaaaacuc caaaccccag                                                   20


<210>  1177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1177
gggguuugga guuuuuaaag                                                   20


<210>  1178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1178
agaaagggca uuugcaacag                                                   20


<210>  1179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1179
acccuuccag cuggaucacg                                                   20


<210>  1180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1180
agcuggaagg guggauaaaa                                                   20


<210>  1181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1181
cgcgcccucu ucaaugacau                                                   20


<210>  1182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1182
aggacggaag gugccggcag                                                   20


<210>  1183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1183
cauagcaagg ccucaaugga                                                   20


<210>  1184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1184
acaaauuuuc ucugccacac                                                   20


<210>  1185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1185
ugggccuaca cagugacaaa                                                   20


<210>  1186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1186
accaacuagg cuggcugucu                                                   20


<210>  1187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1187
agaagagucu gggguuguca                                                   20


<210>  1188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1188
acaaaucuag aagagucugg                                                   20


<210>  1189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1189
gugcaccugc cagaccuguc                                                   20


<210>  1190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1190
ggggaggcug gguaagauuu                                                   20


<210>  1191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1191
uacccagccu ccccagaugg                                                   20


<210>  1192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1192
ccaagcugcu ggcuucagcc                                                   20


<210>  1193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1193
ucagugugag aggcaguuac                                                   20


<210>  1194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1194
ucuuccuugc ucaaagaucc                                                   20


<210>  1195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1195
uugagcaagg aagaagaugc                                                   20


<210>  1196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1196
cacaccccgu uagaagcugg                                                   20


<210>  1197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1197
uuacaucuca ccacggucac                                                   20


<210>  1198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1198
caccacgguc accguggcua                                                   20


<210>  1199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1199
agccacggug accgugguga                                                   20


<210>  1200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1200
cggaggucac aucuagccac                                                   20


<210>  1201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1201
cagugaccag cccugcccag                                                   20


<210>  1202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1202
caugaggugu gaacuugacc                                                   20


<210>  1203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1203
caggaaagaa ggccgggguc                                                   20


<210>  1204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1204
ccuggggaau gccucggccu                                                   20


<210>  1205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1205
cgaaugccac ugccacuucc                                                   20


<210>  1206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1206
agagggaggu cagcccucag                                                   20


<210>  1207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1207
ucugauucug accugaaacu                                                   20


<210>  1208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1208
gaagaugugc aaguuacgca                                                   20


<210>  1209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1209
caggucggca cagacgcaac                                                   20


<210>  1210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1210
acugaaggac guaaguagga                                                   20


<210>  1211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1211
cccacagucc cucugcugga                                                   20


<210>  1212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1212
gagaagggaa acaucaccca                                                   20


<210>  1213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1213
gcaaacuugu uucauuuaua                                                   20


<210>  1214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1214
ccagucccca ugaggcuugu                                                   20


<210>  1215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1215
gcugcgacug guucacugcg                                                   20


<210>  1216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1216
ggaauggucu guguguuauc                                                   20


<210>  1217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1217
cagaggugca uuucaggauu                                                   20


<210>  1218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1218
ugaaaugcac cucugggauc                                                   20


<210>  1219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1219
ggugacguuu uaacagaaac                                                   20


<210>  1220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1220
caccaacauu auagcauuau                                                   20


<210>  1221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1221
accugccuug gccccccaau                                                   20


<210>  1222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1222
gcucaacugc agaacuggca                                                   20


<210>  1223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1223
cccugggagg ccagggcugu                                                   20


<210>  1224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1224
ccgacucugc gaugacucac                                                   20


<210>  1225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1225
cagagucggg gauuucgugu                                                   20


<210>  1226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1226
ugcugcaggg agcucgcagc                                                   20


<210>  1227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1227
caaauaugaa gggaaguaaa                                                   20


<210>  1228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1228
uugcaaaauc acaaauauga                                                   20


<210>  1229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1229
aaugacugac ugccaccagc                                                   20


<210>  1230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1230
ccuggcggac ugcagccacc                                                   20


<210>  1231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1231
gugaggaggg cuuggagagg                                                   20


<210>  1232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1232
uggggccucu ccaagcccuc                                                   20


<210>  1233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1233
uuccacgcca ucauggggcc                                                   20


<210>  1234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1234
gguaugugag gggaccccgc                                                   20


<210>  1235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1235
cauccgguau gugaggggac                                                   20


<210>  1236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1236
ucucuagcag acaccacgag                                                   20


<210>  1237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1237
cuguccuguc gcacuuggaa                                                   20


<210>  1238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1238
acucaccuug gcuugcuuug                                                   20


<210>  1239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1239
caagaagaaa auuaauaagc                                                   20


<210>  1240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1240
ugucccucca ggacguggug                                                   20


<210>  1241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1241
cugggcugcu auuuccaacu                                                   20


<210>  1242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1242
aacccuggca augccgcccg                                                   20


<210>  1243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1243
uuucuuccau cucaugcauc                                                   20


<210>  1244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1244
caugcaucgc aucucggaga                                                   20


<210>  1245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1245
caucucggag aacaaauuug                                                   20


<210>  1246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1246
cggagaacaa auuugauagc                                                   20


<210>  1247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1247
aauuuguucu ccgagaugcg                                                   20


<210>  1248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1248
gcaagugacg cuaucaaauu                                                   20


<210>  1249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1249
ggcaaagaug auauaagugc                                                   20


<210>  1250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1250
uugccagaug uuuccugaau                                                   20


<210>  1251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1251
ucuuugccag auguuuccug                                                   20


<210>  1252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1252
aaagucauuc ucuccugacu                                                   20


<210>  1253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1253
cagaugacac accauuuuua                                                   20


<210>  1254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1254
gggauguggg guuaagcaga                                                   20


<210>  1255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1255
augacuguga ggucuggugg                                                   20


<210>  1256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1256
guagccaaau cgccaacgua                                                   20


<210>  1257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1257
ccaacguauu ccaaaagaaa                                                   20


<210>  1258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1258
acguacuucu aauuuugcuu                                                   20


<210>  1259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1259
aucuuccuaa caacagagau                                                   20


<210>  1260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1260
auggaagagc agcuuuuggu                                                   20


<210>  1261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1261
uccuaacaac agagaucuca                                                   20


<210>  1262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1262
cuguuguuag gaagaucgau                                                   20


<210>  1263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1263
caguuccuca uaggauucag                                                   20


<210>  1264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1264
uaugaggaac ugagaucucu                                                   20


<210>  1265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1265
aaaacacaaa acauacugca                                                   20


<210>  1266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1266
caaaaauaaa uauauauaca                                                   20


<210>  1267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1267
cagcucacug aaacuuccgc                                                   20


<210>  1268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1268
cuugaaccca ggaggcggaa                                                   20


<210>  1269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1269
cagaaccuga ggaaacccgc                                                   20


<210>  1270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1270
acccuuuccc aggagucugc                                                   20


<210>  1271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1271
aacguggaga gugaggaaga                                                   20


<210>  1272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1272
gggcugucgc ucuccucugu                                                   20


<210>  1273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1273
uccucgacau ucaucuuucc                                                   20


<210>  1274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1274
uuccauccua ccaagagcgu                                                   20


<210>  1275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1275
uaccaagagc guggaaacca                                                   20


<210>  1276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1276
uacuuuguag gaaagcaaac                                                   20


<210>  1277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1277
uuaucuagca cgaagccauc                                                   20


<210>  1278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1278
agcacgaagc caucauucag                                                   20


<210>  1279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1279
uucagaucau cugcugacau                                                   20


<210>  1280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1280
gaaugauggc uucgugcuag                                                   20


<210>  1281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1281
ucugcugaca uauguuuugg                                                   20


<210>  1282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1282
gcugacauau guuuugguuu                                                   20


<210>  1283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1283
ucauccuuuc caagcauucu                                                   20


<210>  1284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1284
uuuccaagca uucuucgaag                                                   20


<210>  1285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1285
cauuccuucc ugcucaggcu                                                   20


<210>  1286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1286
uguuagaggg cugcgccuuc                                                   20


<210>  1287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1287
ugucauaugc aucgggcuaa                                                   20


<210>  1288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1288
ggcuaaggua gaaagaagaa                                                   20


<210>  1289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1289
ucucguugag cuugucucuc                                                   20


<210>  1290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1290
cauaaagcau auaccucgga                                                   20


<210>  1291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1291
ucuccacggu aagacaggcu                                                   20


<210>  1292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1292
ucuucuccac gguaagacag                                                   20


<210>  1293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1293
agaacacuca cuaacccacc                                                   20


<210>  1294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1294
gcucuuuccg ggacuucggu                                                   20


<210>  1295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1295
aaaacugacu cucaaagcuu                                                   20


<210>  1296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1296
ucagaacaaa gguguacaaa                                                   20


<210>  1297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1297
ggcaaaacac cuuauuucuc                                                   20


<210>  1298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1298
aggaacguug ucuggugagg                                                   20


<210>  1299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1299
ucagcaucgc ugucacuguc                                                   20


<210>  1300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1300
cugucacugu ccacaauguc                                                   20


<210>  1301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1301
agaagcauaa ugacauugug                                                   20


<210>  1302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1302
ucauuuagau uguagaugcu                                                   20


<210>  1303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1303
aaaugaagau gaagaauuga                                                   20


<210>  1304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1304
acaaucuaaa ugaagaugaa                                                   20


<210>  1305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1305
ugagaaaaaa agcaucuaca                                                   20


<210>  1306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1306
ucuucuccuc ggggcucaug                                                   20


<210>  1307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1307
ucuccucggg gcucauguug                                                   20


<210>  1308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1308
cugaauacau uggauuuauc                                                   20


<210>  1309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1309
aauguauuca gagauaaacg                                                   20


<210>  1310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1310
cuuucuuugu acucuuuuag                                                   20


<210>  1311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1311
cacaaaaaau ucuugugauu                                                   20


<210>  1312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1312
caagaauuuu uugugagauu                                                   20


<210>  1313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1313
cuguccucuc acagcuuucu                                                   20


<210>  1314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1314
gcagagcaaa auuuuaaaac                                                   20


<210>  1315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1315
cacuauuuaa aucacaaggu                                                   20


<210>  1316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1316
caaggucuag cuggcaauca                                                   20


<210>  1317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1317
gaugggagca cauuacaugu                                                   20


<210>  1318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1318
gauugccagc uagaccuugu                                                   20


<210>  1319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1319
agcaguacag gcuagcacau                                                   20


<210>  1320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1320
acccccuucc ugcuagaagc                                                   20


<210>  1321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1321
gccaucucug ccucuaaaaa                                                   20


<210>  1322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1322
cugccucuaa aaauauuagu                                                   20


<210>  1323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1323
ggaauaugau ucuaugggua                                                   20


<210>  1324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1324
caauaaugua gaauaacuca                                                   20


<210>  1325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1325
auauaguuua agaaagaaag                                                   20


<210>  1326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1326
uauggaauuu acggcauaaa                                                   20


<210>  1327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1327
cauuaauauu aauauauuaa                                                   20


<210>  1328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1328
cauuaauauu aauauauuaa                                                   20


<210>  1329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1329
cauuaauauu aauauauuaa                                                   20


<210>  1330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1330
cauuaauauu aauauauuaa                                                   20


<210>  1331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1331
cauuaucaau auauuaauau                                                   20


<210>  1332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1332
auauauuaau auuauaauca                                                   20


<210>  1333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1333
cauuaucaau auauuaauau                                                   20


<210>  1334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1334
auauauuaau auuauaauua                                                   20


<210>  1335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1335
auauuauauu aauauuauau                                                   20


<210>  1336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1336
auauuauuuu aauauuauau                                                   20


<210>  1337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1337
auauaauauu aauauaauau                                                   20


<210>  1338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1338
auauuauuau auuaauauua                                                   20


<210>  1339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1339
auauuauauu aauauuauau                                                   20


<210>  1340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1340
auauuauuuu aauauuauau                                                   20


<210>  1341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1341
auauaauauu aauauaauau                                                   20


<210>  1342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1342
auauuauuau auuaauauua                                                   20


<210>  1343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1343
auauuauauu aauacuacau                                                   20


<210>  1344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1344
auauuauauu aauacuauau                                                   20


<210>  1345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1345
guaacuauau uaauauaguu                                                   20


<210>  1346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1346
ggaccccacg cugcucucgg                                                   20


<210>  1347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1347
ugccuuccgg cuccccgugc                                                   20


<210>  1348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1348
ugggccggaa gacgcgccac                                                   20


<210>  1349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1349
ggaacuucug ccuguuaacu                                                   20


<210>  1350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1350
guucgaggug aaaguuaaca                                                   20


<210>  1351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1351
gcgaguaagc cgagccugcg                                                   20


<210>  1352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1352
cccucgccuc gcgcgcgcaa                                                   20


<210>  1353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1353
ccccgguucu ucuuggcccc                                                   20


<210>  1354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1354
gccggcggcg gcggcgccag                                                   20


<210>  1355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1355
uggccaacuc gcugcugcug                                                   20


<210>  1356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1356
uuauguauag cuugauuaau                                                   20


<210>  1357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1357
agcuauacau aaugaugcuu                                                   20


<210>  1358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1358
aauauuauau auucaacuuc                                                   20


<210>  1359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1359
auguauaucu aauauuauau                                                   20


<210>  1360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1360
ccacaaaaac cacaaaauua                                                   20


<210>  1361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1361
cuugagucca gggguuccag                                                   20


<210>  1362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1362
uacccuccca cuucagccuc                                                   20


<210>  1363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1363
cagcacuuug ggaggcugaa                                                   20


<210>  1364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1364
gacagauaag aaauacuaag                                                   20


<210>  1365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1365
auguaguagu cagccaaauu                                                   20


<210>  1366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1366
cagcacuuug ggaggccgag                                                   20


<210>  1367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1367
uuuuucuuua agguaacuau                                                   20


<210>  1368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1368
uuuuggcuuu auuaaagcuc                                                   20


<210>  1369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1369
guaggauucu ucaugcuugu                                                   20


<210>  1370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1370
uacagauuau uuuguuugag                                                   20


<210>  1371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1371
aggcauaccu accguguuca                                                   20


<210>  1372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1372
gaagcagaag uggcccaaaa                                                   20


<210>  1373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1373
uuauaaaaau ggaaaauugg                                                   20


<210>  1374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1374
uguuggauua gggcccaccc                                                   20


<210>  1375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1375
aacaugauug guauccuuau                                                   20


<210>  1376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1376
ccaaauaaga ucacugucug                                                   20


<210>  1377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1377
uauuuggaga uaggguauuu                                                   20


<210>  1378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1378
cugucugagg guuaggggcu                                                   20


<210>  1379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1379
uaacugcuau ucauacauuc                                                   20


<210>  1380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1380
ugggcuuugg agccagccag                                                   20


<210>  1381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1381
cagugcccuc uuuauacuau                                                   20


<210>  1382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1382
caacgacggu gucaguuacu                                                   20


<210>  1383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1383
cuagagccaa gcuuagugcc                                                   20


<210>  1384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1384
cuguaucccu agagccaagc                                                   20


<210>  1385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1385
guuuuuauuc aucccuguau                                                   20


<210>  1386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1386
ccuucugaga agcugacagu                                                   20


<210>  1387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1387
auccuaaaga uccauauuga                                                   20


<210>  1388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1388
uaaagaucca uauugagugg                                                   20


<210>  1389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1389
uuaggauaga uuaauacagc                                                   20


<210>  1390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1390
auauugagug ggaagaaaaa                                                   20


<210>  1391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1391
uuaaaauuac uuuauguaga                                                   20


<210>  1392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1392
agcuaccuca gccuccucag                                                   20


<210>  1393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1393
cuugagucca ggaagucaag                                                   20


<210>  1394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1394
caaaaaagaa aaaaaauggu                                                   20


<210>  1395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1395
uauuuaaucu ccacaacaag                                                   20


<210>  1396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1396
ccacaacaag ccuacuagau                                                   20


<210>  1397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1397
aguaggcuug uuguggagau                                                   20


<210>  1398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1398
cagcaucuag uaggcuuguu                                                   20


<210>  1399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1399
caaugugcaa auaccccaga                                                   20


<210>  1400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1400
aggugcuguu cugggguauu                                                   20


<210>  1401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1401
ggaccaguag ugaaagacaa                                                   20


<210>  1402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1402
caugccugcc aagggcaagc                                                   20


<210>  1403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1403
gccugcagaa aggagcuacc                                                   20


<210>  1404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1404
ucccaucguc ugugcagccc                                                   20


<210>  1405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1405
caucgucugu gcagcccuca                                                   20


<210>  1406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1406
ucugugcagc ccucagagga                                                   20


<210>  1407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1407
cuggcuugaa ggugagguuu                                                   20


<210>  1408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1408
uugagcagag aacaaguccc                                                   20


<210>  1409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1409
ucaguggugc uucugugccc                                                   20


<210>  1410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1410
acaagugccc ugagacaugg                                                   20


<210>  1411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1411
ugcuuguuuu ccacuugugg                                                   20


<210>  1412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1412
agagggcaaa auacugcauc                                                   20


<210>  1413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1413
ggcaagugac agcucagcuc                                                   20


<210>  1414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1414
ucccccucaa auccagucca                                                   20


<210>  1415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1415
uguggugugg gacgugaguc                                                   20


<210>  1416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1416
aacaugacau auuguucagg                                                   20


<210>  1417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1417
uguuuacaga uuuggaaacu                                                   20


<210>  1418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1418
guaaacaaga ucuaacauga                                                   20


<210>  1419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1419
ugaauaaaaa uacaugcuua                                                   20


<210>  1420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1420
uaacauuucu guuugagugg                                                   20


<210>  1421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1421
uccugaauuu gggagaaaaa                                                   20


<210>  1422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1422
ccuuccauuu uuuacuacga                                                   20


<210>  1423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1423
aagcauuagu aggcacuauu                                                   20


<210>  1424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1424
ggcaugauac cauucauuag                                                   20


<210>  1425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1425
ugaagauaua aggagaauuu                                                   20


<210>  1426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1426
uuuagauuuu cugaucugca                                                   20


<210>  1427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1427
aaaggauuuu uuuuccugag                                                   20


<210>  1428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1428
gaaaaucuaa aggauuuuuu                                                   20


<210>  1429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1429
gcaguuauaa aguuggcugu                                                   20


<210>  1430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1430
aucuuuccuu uaguacuauu                                                   20


<210>  1431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1431
uuccuuuagu acuauuguag                                                   20


<210>  1432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1432
uucuuuaaaa ggaacuacaa                                                   20


<210>  1433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1433
ucuuucuuua aaaggaacua                                                   20


<210>  1434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1434
uuuauccguu uuaaaaauug                                                   20


<210>  1435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1435
guuuuaaaaa uuggauuguc                                                   20


<210>  1436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1436
aauuuuuaaa acggauaaaa                                                   20


<210>  1437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1437
uauaccucaa caacaaaaag                                                   20


<210>  1438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1438
agaacauaga aagaaaucuu                                                   20


<210>  1439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1439
aauaucuaga acauagaaag                                                   20


<210>  1440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1440
guuaagcauc uaauaucuag                                                   20


<210>  1441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1441
ccugaacccg ggaggcagag                                                   20


<210>  1442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1442
agugagaacu guaaggcuua                                                   20


<210>  1443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1443
uuacagucca ccacaugcug                                                   20


<210>  1444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1444
cuuugcuuca cccagaaaag                                                   20


<210>  1445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1445
uuuucugggu gaagcaaagg                                                   20


<210>  1446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1446
guugcuuguc acaaagacug                                                   20


<210>  1447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1447
cagaacugcc ugaagagacg                                                   20


<210>  1448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1448
aagaauucaa ugugccucuu                                                   20


<210>  1449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1449
ccauauugag caaccaccca                                                   20


<210>  1450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1450
uaugcuuuug aaaauguaaa                                                   20


<210>  1451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1451
cagcauuuug gaaggcugag                                                   20


<210>  1452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1452
gcccgccuca gccuuccaaa                                                   20


<210>  1453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1453
ugaggucagg agaucgagac                                                   20


<210>  1454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1454
ccugaccuca ugauccgccc                                                   20


<210>  1455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1455
agaccauccu gaccaacaca                                                   20


<210>  1456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1456
ugaccaacac agugaaaccc                                                   20


<210>  1457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1457
cuugaaccag gaggcggagg                                                   20


<210>  1458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1458
guaucaguca ggauucaacc                                                   20


<210>  1459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1459
gucaggauuc aaccagagaa                                                   20


<210>  1460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1460
ugacugauac agaugccacu                                                   20


<210>  1461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1461
cuguucuuaa caccuuccaa                                                   20


<210>  1462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1462
guuggaaggu guuaagaaca                                                   20


<210>  1463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1463
cuuaaaaaaa aaaaaaaaag                                                   20


<210>  1464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1464
caucucuuaa aaaaaaaaaa                                                   20


<210>  1465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1465
cgcuauguug cucaggcugg                                                   20


<210>  1466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1466
cuccaaucag gcagaauaug                                                   20


<210>  1467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1467
ggcagaauau gaaguugccg                                                   20


<210>  1468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1468
gcaacuucau auucugccug                                                   20


<210>  1469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1469
ucggcaacuu cauauucugc                                                   20


<210>  1470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1470
cuucgguccu caucaucggc                                                   20


<210>  1471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1471
uagauagauu cuucaaugau                                                   20


<210>  1472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1472
aagauugaca guccacaauc                                                   20


<210>  1473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1473
aucuaagauu gacaguccac                                                   20


<210>  1474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1474
uugaagaauc uaucuaagau                                                   20


<210>  1475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1475
acaaauuuuu auucuaaaga                                                   20


<210>  1476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1476
cagcacuucg ggaggcugag                                                   20


<210>  1477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1477
uccuuccuca gccucccgaa                                                   20


<210>  1478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1478
cuuuagccca ggaguucgag                                                   20


<210>  1479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1479
cgaacuccug ggcuaaagag                                                   20


<210>  1480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1480
gcauggccaa cauagugaga                                                   20


<210>  1481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1481
cuacaaaaaa auaaacaaaa                                                   20


<210>  1482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1482
guagucccag cuacuuggga                                                   20


<210>  1483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1483
aacaaaaugc aaaagaggaa                                                   20


<210>  1484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1484
aauuguuagu uuccucauga                                                   20


<210>  1485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1485
cuuagaaaau ugauucagug                                                   20


<210>  1486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1486
auuuucuaag agaucuaauu                                                   20


<210>  1487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1487
ugggguuugu uguacagauu                                                   20


<210>  1488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1488
guacaacaaa ccccaugaug                                                   20


<210>  1489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1489
cccagguauu aagcuuagca                                                   20


<210>  1490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1490
uaaccaaaac caagugggcu                                                   20


<210>  1491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1491
gaaaaucaau uacuauaaua                                                   20


<210>  1492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1492
auuacuauaa uacaccauau                                                   20


<210>  1493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1493
ugugguuuuu aaauauuuua                                                   20


<210>  1494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1494
uaauaaaaau agaaaaagua                                                   20


<210>  1495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1495
augaaauacc cacagccaac                                                   20


<210>  1496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1496
uacuuaaaug ugaaagacua                                                   20


<210>  1497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1497
ugcagccuua ccagacucac                                                   20


<210>  1498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1498
aaaaaaaaag aaauuaagaa                                                   20


<210>  1499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1499
aaaaagaaua aaauacuuaa                                                   20


<210>  1500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1500
ccuguucgug gaucagaaga                                                   20


<210>  1501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1501
acgaacagga gaugucuuuc                                                   20


<210>  1502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1502
gaagacuuaa uauuguuaag                                                   20


<210>  1503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1503
uaacaauauu aagucuucug                                                   20


<210>  1504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1504
auuuggggag uacugccauc                                                   20


<210>  1505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1505
auagauucaa uauaaucccu                                                   20


<210>  1506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1506
agacaguaug guccuggcau                                                   20


<210>  1507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1507
ugccaggacc auacugucuu                                                   20


<210>  1508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1508
uuaaacgguc uugauagaau                                                   20


<210>  1509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1509
agaccguuua augauuaaca                                                   20


<210>  1510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1510
accugcuauu uaguuucaga                                                   20


<210>  1511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1511
guugagguca ggaguucaag                                                   20


<210>  1512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1512
acauaacucu gccucccaaa                                                   20


<210>  1513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1513
aaguuguagc guauuucaga                                                   20


<210>  1514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1514
auucauccac agacaccugg                                                   20


<210>  1515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1515
acagacaccu ggguuguuuu                                                   20


<210>  1516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1516
gcacacccau guucauugca                                                   20


<210>  1517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1517
ccugaaguca ggaguuugag                                                   20


<210>  1518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1518
acccaccucg gccucccaaa                                                   20


<210>  1519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1519
cuaaugguua uguauuuggu                                                   20


<210>  1520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1520
ggagguauuu cugguaaagg                                                   20


<210>  1521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1521
acauucuguc acaacaucug                                                   20


<210>  1522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1522
augacuaacc ccaaaacaga                                                   20


<210>  1523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1523
aaaccaccca gcuccucagu                                                   20


<210>  1524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1524
guggggugug gaacuggccg                                                   20


<210>  1525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1525
aacaagaaua aguaagauga                                                   20


<210>  1526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1526
caaacacuag aauaccauua                                                   20


<210>  1527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1527
uuuuggaaag caguucaaau                                                   20


<210>  1528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1528
gagagcaaag accaagccug                                                   20


<210>  1529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1529
caggaccagu aucagagagc                                                   20


<210>  1530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1530
caauauccca ggaccaguau                                                   20


<210>  1531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1531
gauuucuucc ugucuucauc                                                   20


<210>  1532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1532
gauucuuauc acaauauccc                                                   20


<210>  1533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1533
gggaugccac agaggccagg                                                   20


<210>  1534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1534
cagaugaaga caggaagaaa                                                   20


<210>  1535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1535
uucaguccac gcuuuugucc                                                   20


<210>  1536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1536
cucuccuggg cauguacaca                                                   20


<210>  1537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1537
ugccuauuuc auacaguuac                                                   20


<210>  1538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1538
cuguuuuaca gaaggagaaa                                                   20


<210>  1539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1539
agcagcaugc uucccaugug                                                   20


<210>  1540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1540
uucuauuuca cugcuuuuuu                                                   20


<210>  1541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1541
uuuucuagag uugcccauaa                                                   20


<210>  1542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1542
guacauaccu uuccagccau                                                   20


<210>  1543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1543
aguuuaaaau caguacauac                                                   20


<210>  1544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1544
uucagccuca gccuccugag                                                   20


<210>  1545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1545
cguacuauag ccuugaaguc                                                   20


<210>  1546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1546
ucccguacua uagccuugaa                                                   20


<210>  1547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1547
agccugugaa uagccacugc                                                   20


<210>  1548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1548
cuguugguuc aguggcuaga                                                   20


<210>  1549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1549
uugagguucu uuuuucaaag                                                   20


<210>  1550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1550
uuugaaaaaa gaaccucaaa                                                   20


<210>  1551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1551
aggaggcgga gguugcagug                                                   20


<210>  1552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1552
aggcucacug caaccuccgc                                                   20


<210>  1553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1553
ugccacugca cuccagcccu                                                   20


<210>  1554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1554
caaaaaaaaa aaaaaaaaaa                                                   20


<210>  1555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1555
uuuuuuuuuu uuuuuuuuuu                                                   20


<210>  1556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1556
ugcuagaggg agccacaguc                                                   20


<210>  1557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1557
ccuuugagca gaaugguuca                                                   20


<210>  1558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1558
augagaaaaa caaguuucag                                                   20


<210>  1559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1559
gccuuuuccu agaacucugu                                                   20


<210>  1560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1560
gcucucccag uacacuguug                                                   20


<210>  1561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1561
uugccaacug ugagaaucca                                                   20


<210>  1562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1562
acauggaauu uugagcaaaa                                                   20


<210>  1563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1563
cuucucuugg ugacuucacc                                                   20


<210>  1564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1564
agcauggaaa ccagcuucuu                                                   20


<210>  1565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1565
gggcaaagug acugagcugg                                                   20


<210>  1566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1566
ucuuuccauc ugggcaaagu                                                   20


<210>  1567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1567
uggaaauucc acaaugcgga                                                   20


<210>  1568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1568
aaagguguuu ggaaaugugu                                                   20


<210>  1569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1569
uaaggaaaug acucacagac                                                   20


<210>  1570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1570
caaaacaaaa caaaacaaaa                                                   20


<210>  1571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1571
cgccauugca cuccagucua                                                   20


<210>  1572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1572
cagcucacca caaccuccgc                                                   20


<210>  1573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1573
cuugaacuca ggaggcggag                                                   20


<210>  1574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1574
cccgaggucg ggaguucaag                                                   20


<210>  1575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1575
gcccuccuca gccucccaaa                                                   20


<210>  1576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1576
cagcacuuug ggaggcugag                                                   20


<210>  1577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1577
uauuuaaaca acaccccggg                                                   20


<210>  1578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1578
aggagaccca ucauauuuaa                                                   20


<210>  1579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1579
accaacuaca guggucucca                                                   20


<210>  1580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1580
ccagaccaga acugcugcug                                                   20


<210>  1581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1581
cuuuaaaucc ccagaccaga                                                   20


<210>  1582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1582
cuccagguaa cuaguaaggu                                                   20


<210>  1583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1583
uauggaguuc aagaacuuuu                                                   20


<210>  1584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1584
gagucacacc cgggcagugu                                                   20


<210>  1585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1585
guuaugcacc ugcagcuuga                                                   20


<210>  1586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1586
aaucguaugc uugcucuaau                                                   20


<210>  1587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1587
uaugcuugcu cuaaucccuc                                                   20


<210>  1588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1588
cuccaugaua gauauuucug                                                   20


<210>  1589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1589
uggagggauu agagcaagca                                                   20


<210>  1590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1590
aucauggagg gauuagagca                                                   20


<210>  1591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1591
acccucuguu ugaauauguc                                                   20


<210>  1592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1592
gccuuuaaug aucugcaaau                                                   20


<210>  1593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1593
uuaaaggcag auuagcaaga                                                   20


<210>  1594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1594
gcaaauguaa ugacucagau                                                   20


<210>  1595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1595
gagucauuac auuugcagau                                                   20


<210>  1596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1596
uauuaagacu gacauguuuu                                                   20


<210>  1597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1597
uagcacuucg ggaggccaag                                                   20


<210>  1598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1598
gccuaccuug gccucccgaa                                                   20


<210>  1599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1599
cuugagccca gaaguuccag                                                   20


<210>  1600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1600
ggaacuucug ggcucaagcg                                                   20


<210>  1601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1601
gccuaggcaa cauggcaaga                                                   20


<210>  1602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1602
cuauuuaaau auuuaauaua                                                   20


<210>  1603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1603
ucuuuuuuaa uguauuuauu                                                   20


<210>  1604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1604
uaauuauacu gagucuuucu                                                   20


<210>  1605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1605
auacaaucau aauuauacug                                                   20


<210>  1606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1606
guuaaaaagu aaucuauaca                                                   20


<210>  1607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1607
uuuguuuggg aacccaagua                                                   20


<210>  1608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1608
agauucuaau cgugcauuug                                                   20


<210>  1609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1609
ggauuaaagg gcaccgaggc                                                   20


<210>  1610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1610
ugcauuugcu uuuuccaagu                                                   20


<210>  1611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1611
cugcugucau gguuuuaggc                                                   20


<210>  1612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1612
cuuccagcag cgugaucuug                                                   20


<210>  1613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1613
cgcugcugga agugauacga                                                   20


<210>  1614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1614
ugggcccgcc aucgugaucu                                                   20


<210>  1615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1615
ugaucucauc ucuagcaggg                                                   20


<210>  1616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1616
cgauggcggg cccaagauca                                                   20


<210>  1617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1617
caucucuagc agggaaauaa                                                   20


<210>  1618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1618
cuagcaggga aauaaucggc                                                   20


<210>  1619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1619
gcccugcccg ccaggcugcu                                                   20


<210>  1620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1620
uggaauuacg ggugaguuuu                                                   20


<210>  1621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1621
cuguccuuau uacuuccaau                                                   20


<210>  1622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1622
agcaaagagc uuccuuugug                                                   20


<210>  1623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1623
acuuugcacu uucuccagaa                                                   20


<210>  1624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1624
aacaaugcac agugaagacu                                                   20


<210>  1625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1625
cuccuucuau guuuucuaag                                                   20


<210>  1626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1626
guaguccccc gccucccauu                                                   20


<210>  1627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1627
cagccagcca gagcuuaucu                                                   20


<210>  1628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1628
cuguuugcuc ucagccucca                                                   20


<210>  1629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1629
ucaagcacag ccaagucaca                                                   20


<210>  1630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1630
ugccauugcg cuccagccug                                                   20


<210>  1631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1631
ugggucacug cagccucaac                                                   20


<210>  1632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1632
ccaaaaaaaa aaaaaaaaaa                                                   20


<210>  1633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1633
ucccaccaca gccuucugag                                                   20


<210>  1634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1634
cacucuguca cccaggcugg                                                   20


<210>  1635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1635
caucucaaaa acaaagcaaa                                                   20


<210>  1636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1636
caaaaacaaa gcaaaacaaa                                                   20


<210>  1637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1637
aagcauuuaa gcaaaagaaa                                                   20


<210>  1638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1638
uuggccucuc ccaaggaacc                                                   20


<210>  1639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1639
cuuacuuucu cuccucuugu                                                   20


<210>  1640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1640
uuacuaauuc aagggccagu                                                   20


<210>  1641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1641
ugaccaaguu ggauuuauuc                                                   20


<210>  1642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1642
aacuugguca ugauguauua                                                   20


<210>  1643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1643
aauaauguaa uuuaucacgu                                                   20


<210>  1644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1644
cguuaccaga auaaagggaa                                                   20


<210>  1645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1645
cuugguuaaa uccuuaauag                                                   20


<210>  1646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1646
gccacuaaca auuagaaaau                                                   20


<210>  1647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1647
guaacauuuc cauuuucuaa                                                   20


<210>  1648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1648
agaaacauca aaaucuaaga                                                   20


<210>  1649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1649
cagcuacucg ggaggcugag                                                   20


<210>  1650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1650
cuugaaaccu gggagacaga                                                   20


<210>  1651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1651
cggcucacug caaccucugu                                                   20


<210>  1652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1652
uaaaaacaga acacgaacuu                                                   20


<210>  1653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1653
uugguuucau aagcguaggc                                                   20


<210>  1654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1654
ccuccauuca uaauggugag                                                   20


<210>  1655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1655
cggcuuugau gagcagagag                                                   20


<210>  1656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1656
aagccgggau ugcccagguu                                                   20


<210>  1657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1657
uccaagccgc aacacagcuc                                                   20


<210>  1658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1658
uggaagcagc cagugugaac                                                   20


<210>  1659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1659
agggccuccc agcuauucuc                                                   20


<210>  1660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1660
ccaucgaggg ccucccagcu                                                   20


<210>  1661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1661
gggacuugag gacccuugga                                                   20


<210>  1662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1662
aaggguccuc aagucccuga                                                   20


<210>  1663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1663
aaauccaagg guccucaagu                                                   20


<210>  1664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1664
aagggaaagg ggccugcugu                                                   20


<210>  1665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1665
ggucccacag caggccccuu                                                   20


<210>  1666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1666
caaaggccac gagggccagg                                                   20


<210>  1667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1667
ugcgaggguu uuagcugcuc                                                   20


<210>  1668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1668
gcccagaguu ggcccacaca                                                   20


<210>  1669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1669
ucaugcucac acccucgugc                                                   20


<210>  1670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1670
uccaacugcu ccccguguug                                                   20


<210>  1671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1671
gagcagacaa cacggggagc                                                   20


<210>  1672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1672
ucugacguga ccaucugagc                                                   20


<210>  1673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1673
aggacuccca agaagcucau                                                   20


<210>  1674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1674
cauuucuucc uauucugaug                                                   20


<210>  1675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1675
gaauaggaag aaaugagauc                                                   20


<210>  1676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1676
uauauauccc acagccaaua                                                   20


<210>  1677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1677
cacagccaau augggauaaa                                                   20


<210>  1678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1678
cauauuggcu gugggauaua                                                   20


<210>  1679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1679
cuuaaggacc agagaccagg                                                   20


<210>  1680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1680
accccuugcu caaugcucaa                                                   20


<210>  1681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1681
ccuaugggug uguuccaugg                                                   20


<210>  1682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1682
aaucuccuau ggguguguuc                                                   20


<210>  1683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1683
cacuucacag gugacuacgg                                                   20


<210>  1684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1684
ugagacugaa accaaacaca                                                   20


<210>  1685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1685
agcucaucuu gagacugaaa                                                   20


<210>  1686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1686
ucuaaccucc gguacccacu                                                   20


<210>  1687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1687
accgcugugu ccacgggacu                                                   20


<210>  1688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1688
guagguauca cuaagcauuu                                                   20


<210>  1689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1689
cuaagcauuu guugaaugaa                                                   20


<210>  1690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1690
gucauucauu caacaaaugc                                                   20


<210>  1691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1691
cugaaauguc uucaaaucug                                                   20


<210>  1692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1692
guauaacuau gcaaagaagu                                                   20


<210>  1693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1693
cagcaaacaa cucacaugug                                                   20


<210>  1694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1694
cagugccaac uucugaauaa                                                   20


<210>  1695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1695
aggagaauau ucucaggcuu                                                   20


<210>  1696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1696
ucaaggagaa uauucucagg                                                   20


<210>  1697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1697
ugguaagugg gcaagccuuu                                                   20


<210>  1698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1698
aauggguaga cuuuguuaga                                                   20


<210>  1699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1699
aagucccucu aacaaagucu                                                   20


<210>  1700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1700
aacuuucugu auccaagucc                                                   20


<210>  1701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1701
uuaaguccac uuucugcauc                                                   20


<210>  1702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1702
uuuuaaaaug aacacauacc                                                   20


<210>  1703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1703
cugcuucuug ccuaaacaca                                                   20


<210>  1704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1704
uuaauugaaa auuaugacca                                                   20


<210>  1705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1705
uagcucacug cagccuugaa                                                   20


<210>  1706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1706
cagcuuucug cauagcuggg                                                   20


<210>  1707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1707
cuacaaaaaa aauuuaaaaa                                                   20


<210>  1708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1708
gcacccugcu cugugacaca                                                   20


<210>  1709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1709
uugcauucug gguaugacuc                                                   20


<210>  1710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1710
ccgccuuaga cgccuguccu                                                   20


<210>  1711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1711
ggcagaggca uaaaaggaga                                                   20


<210>  1712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1712
aauucaugua ugacacccug                                                   20


<210>  1713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1713
ccuuccauua aaugagaauu                                                   20


<210>  1714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1714
ugguaucgcc uuccauuaaa                                                   20


<210>  1715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1715
gacuugucca agguuguguc                                                   20


<210>  1716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1716
ccaagcuaug ugguugaucg                                                   20


<210>  1717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1717
accacauagc uuggagauug                                                   20


<210>  1718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1718
gaacagggua cggugcagag                                                   20


<210>  1719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1719
ugagaaaugg uuagaaguga                                                   20


<210>  1720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1720
cuucuaacca uuucucauga                                                   20


<210>  1721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1721
gugugcuccc cugccuuguu                                                   20


<210>  1722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1722
ccuaaaaaca cagaaaaagg                                                   20


<210>  1723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1723
uggcgcagga ggggaaccug                                                   20


<210>  1724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1724
gaaaggcacu cccggguggg                                                   20


<210>  1725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1725
cacccgggag ugccuuucag                                                   20


<210>  1726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1726
uggcauccca cccgggagug                                                   20


<210>  1727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1727
gaggacugug guccccaaga                                                   20


<210>  1728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1728
gcaucagagg acuguggucc                                                   20


<210>  1729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1729
caccugugag uagcuacugc                                                   20


<210>  1730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1730
agcagcgauu aaggauauuu                                                   20


<210>  1731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1731
cugcuggaug ugguggugca                                                   20


<210>  1732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1732
uuaaucgcug cuggaugugg                                                   20


<210>  1733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1733
cuacagcccu ggaggucaaa                                                   20


<210>  1734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1734
gccuugccuc agccuccuga                                                   20


<210>  1735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1735
ggcuaauuuu aaaaaauugu                                                   20


<210>  1736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1736
uaguacuuug ggaggcugag                                                   20


<210>  1737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1737
accugccuca gccucccaaa                                                   20


<210>  1738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1738
cuugagguca agaguucgag                                                   20


<210>  1739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1739
cagcuacuca ggaggccgag                                                   20


<210>  1740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1740
cuugaacccg ggcggcagag                                                   20


<210>  1741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1741
cggcucacug caaccucugc                                                   20


<210>  1742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1742
caauauuuug ggaggccaag                                                   20


<210>  1743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1743
accugccuug gccucccaaa                                                   20


<210>  1744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1744
ccugaaguca ggaguucaag                                                   20


<210>  1745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1745
cuugaaccug ggaggcggag                                                   20


<210>  1746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1746
agccauugca cuccagccua                                                   20


<210>  1747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1747
uucccuucug ugcgguuaaa                                                   20


<210>  1748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1748
agcugguggu uuaaccgcac                                                   20


<210>  1749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1749
cuaaaaauug aaagcaaaau                                                   20


<210>  1750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1750
aauuuuuuuu uuuuuuuuuu                                                   20


<210>  1751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1751
cgccacugca caccagccug                                                   20


<210>  1752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1752
cggcucacug uaagcuccgc                                                   20


<210>  1753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1753
uggcuaacac ggugaaaccc                                                   20


<210>  1754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1754
agaccauccu ggcuaacacg                                                   20


<210>  1755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1755
ccugaccuug ugauccgccc                                                   20


<210>  1756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1756
caaggucagg agaucgagac                                                   20


<210>  1757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1757
gcccgccucg gccucccaaa                                                   20


<210>  1758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1758
cagcacuuug ggaggccgag                                                   20


<210>  1759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1759
aauuuuuuaa uguuauaauu                                                   20


<210>  1760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1760
uuggaaccac auaaauguuu                                                   20


<210>  1761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1761
uaagaugucu agauuccauc                                                   20


<210>  1762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1762
uacgauacac ucuauuuugc                                                   20


<210>  1763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1763
agacaucuua cgauacacuc                                                   20


<210>  1764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1764
cugaccaucc ccaaguaauu                                                   20


<210>  1765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1765
ccaaguaauu auuuuaacuc                                                   20


<210>  1766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1766
auacauauau aguauguaaa                                                   20


<210>  1767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1767
ccaccguaua uucagugaaa                                                   20


<210>  1768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1768
ccaccggugc uguuuccguu                                                   20


<210>  1769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1769
cggcaccaac ggaaacagca                                                   20


<210>  1770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1770
uugauagagu ccuagaagug                                                   20


<210>  1771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1771
aggauacauu caacgaaaua                                                   20


<210>  1772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1772
gacaaauugc guaugaauuc                                                   20


<210>  1773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1773
ggcaauaucu gacaaauugc                                                   20


<210>  1774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1774
auuuuuauaa gaaaaauaag                                                   20


<210>  1775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1775
uugucuuauu uuucuuauaa                                                   20


<210>  1776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1776
cagcacuuug ggaggccagg                                                   20


<210>  1777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1777
ucccacccug gccucccaaa                                                   20


<210>  1778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1778
cuugagccca ggaguucaag                                                   20


<210>  1779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1779
acauuucauu uucuuuucuu                                                   20


<210>  1780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1780
guacaagggg aggaaacuga                                                   20


<210>  1781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1781
ugucucaguu uccuccccuu                                                   20


<210>  1782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1782
ggcugggucu gugcuccuca                                                   20


<210>  1783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1783
cgugcaugca ucugagucag                                                   20


<210>  1784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1784
gagucagagg ccggcuuucc                                                   20


<210>  1785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1785
ugcagacugu uuuaaaauga                                                   20


<210>  1786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1786
uacccuggcc uacaguaggu                                                   20


<210>  1787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1787
ucagcuucua auaucauacc                                                   20


<210>  1788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1788
ucaacuuauu caccacuuau                                                   20


<210>  1789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1789
uucuacacac ucaacagaau                                                   20


<210>  1790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1790
aaaacauucu guugagugug                                                   20


<210>  1791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1791
gucucaaaaa aauuauaaag                                                   20


<210>  1792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1792
caccacugca gggcaagagu                                                   20


<210>  1793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1793
ugguucaccg cagccucgac                                                   20


<210>  1794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1794
cuuaagccca gaaggucgag                                                   20


<210>  1795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1795
uccugccuca gccuccagag                                                   20


<210>  1796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1796
cacccagcua auuuuuuuaa                                                   20


<210>  1797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1797
uuuuuuauag agacaggguc                                                   20


<210>  1798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1798
uccgaccuug gccucccaaa                                                   20


<210>  1799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1799
uucuauauuc aacgcauuaa                                                   20


<210>  1800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1800
uucaugugua gcugucccug                                                   20


<210>  1801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1801
acuacagaac aguaaauaaa                                                   20


<210>  1802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1802
auaaaaauau aaugaauauu                                                   20


<210>  1803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1803
aguguuucug ucuuaucaag                                                   20


<210>  1804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1804
agugguggcc uaugauuaaa                                                   20


<210>  1805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1805
uaggccacca cuugauaaga                                                   20


<210>  1806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1806
ggaagcccuu uaaucauagg                                                   20


<210>  1807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1807
auagccaggc aaaaaucgaa                                                   20


<210>  1808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1808
aauuuuccug cugcuaguga                                                   20


<210>  1809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1809
ggauuucaga ccucgguuug                                                   20


<210>  1810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1810
ggaugugucc uguguguuca                                                   20


<210>  1811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1811
cuguggccaa accgaggucu                                                   20


<210>  1812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1812
cagaaggaca gaggguucga                                                   20


<210>  1813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1813
gggugccuga gugccucaga                                                   20


<210>  1814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1814
acccugaaug gaccggggcc                                                   20


<210>  1815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1815
acuagugugu ccaaaccgag                                                   20


<210>  1816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1816
cuaaccuguc agaguguuga                                                   20


<210>  1817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1817
ccagcagccu caacacucug                                                   20


<210>  1818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1818
uguaggcugc ccucagcuuc                                                   20


<210>  1819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1819
guaagaagcu gagggcagcc                                                   20


<210>  1820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1820
ggaugacacc gcaggucucc                                                   20


<210>  1821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1821
cgauucugcc cucacuucgc                                                   20


<210>  1822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1822
ccccacucug guuauuccaa                                                   20


<210>  1823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1823
uuggaauaac cagagugggg                                                   20


<210>  1824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1824
gggggcagug ccagccaacc                                                   20


<210>  1825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1825
cagggcagug aaaaacccca                                                   20


<210>  1826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1826
aucccagggc agugaaaaac                                                   20


<210>  1827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1827
uggaugaauc auacaaaugu                                                   20


<210>  1828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1828
aagaugagcu gaauugccac                                                   20


<210>  1829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1829
uacaaauguu uaaaaauauu                                                   20


<210>  1830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1830
caauaaagcu aauauuuuua                                                   20


<210>  1831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1831
ucaaguccac caguuugaag                                                   20


<210>  1832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1832
aguccaccag uuugaagugu                                                   20


<210>  1833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1833
guuguauuac acacuucaaa                                                   20


<210>  1834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1834
ccaccaucua auuucacaac                                                   20


<210>  1835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1835
aauuucacaa cuuuuuuuuu                                                   20


<210>  1836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1836
uggcucacug caacguccac                                                   20


<210>  1837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1837
cuugugccug ggagguggac                                                   20


<210>  1838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1838
ggaacuacag gcgccugccg                                                   20


<210>  1839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1839
ggaguuugag accagccugg                                                   20


<210>  1840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1840
caggugaucu gccugccuuc                                                   20


<210>  1841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1841
ccugagauca ggaguuugag                                                   20


<210>  1842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1842
gccugccuuc gccucccaaa                                                   20


<210>  1843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1843
cagcauuuug ggaggcgaag                                                   20


<210>  1844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1844
aaauuuaacu uaauuuccau                                                   20


<210>  1845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1845
ggacuaaacg uauacuuuuc                                                   20


<210>  1846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1846
gacagccaag uccccaccaa                                                   20


<210>  1847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1847
augaaaugau ucagggacau                                                   20


<210>  1848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1848
uuucauagau cagacagcca                                                   20


<210>  1849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1849
accuccuccc auuugacuuu                                                   20


<210>  1850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1850
aagaaucaag aaugauaccg                                                   20


<210>  1851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1851
agaaugauac cgaggaguau                                                   20


<210>  1852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1852
uucuugauuc uuugaucgac                                                   20


<210>  1853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1853
ucugaaaacu ucucagaaua                                                   20


<210>  1854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1854
aucugcagga ugguaaguca                                                   20


<210>  1855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1855
gcaggauggu aagucaggcu                                                   20


<210>  1856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1856
ugcagauaga uuuggcaucc                                                   20


<210>  1857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1857
ucagcaaguc cuggucaccc                                                   20


<210>  1858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1858
caguggcagg agcaugggga                                                   20


<210>  1859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1859
gacaaaaaga gccagugaga                                                   20


<210>  1860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1860
ugucuggaaa cuuuucucac                                                   20


<210>  1861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1861
ggaaaugacu uaauuggguu                                                   20


<210>  1862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1862
aaacccaauu aagucauuuc                                                   20


<210>  1863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1863
aaccaugaau uuuacugugu                                                   20


<210>  1864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1864
uucauguauu uugagguggg                                                   20


<210>  1865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1865
cuggcaggug gcuaaacccu                                                   20


<210>  1866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1866
ccuugcugug acucgcgggu                                                   20


<210>  1867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1867
gccucuggga cuggacugug                                                   20


<210>  1868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1868
gugagggaaa cucucuuugu                                                   20


<210>  1869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1869
uuguugaaug aaaauaaaug                                                   20


<210>  1870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1870
uguauguucc aggcaccguc                                                   20


<210>  1871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1871
cugucugcuc ugcccagcag                                                   20


<210>  1872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1872
uugucaagcc uugaguguug                                                   20


<210>  1873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1873
gaggaagcaa cacucaaggc                                                   20


<210>  1874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1874
cagggcucug ugaagaguga                                                   20


<210>  1875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1875
cucuucacag agcccugcga                                                   20


<210>  1876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1876
caucacucuu cacagagccc                                                   20


<210>  1877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1877
cugcaaagcc cccaauggcc                                                   20


<210>  1878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1878
ccgaggucug cgucaccuuu                                                   20


<210>  1879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1879
cuucucacac cugcucugcc                                                   20


<210>  1880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1880
gccaucacuu cucacaccug                                                   20


<210>  1881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1881
gacagcgguc aucugccauc                                                   20


<210>  1882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1882
ugaaucugac agcggucauc                                                   20


<210>  1883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1883
auccugaauc ugacagcggu                                                   20


<210>  1884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1884
ugaaggcagg ugguggagaa                                                   20


<210>  1885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1885
uggagucagc cugaagucuu                                                   20


<210>  1886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1886
gagaaaaaga agcuccauaa                                                   20


<210>  1887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1887
agagcccaug cggaccugaa                                                   20


<210>  1888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1888
uguugaaccu gccguucccu                                                   20


<210>  1889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1889
uucuaacucu ggccuggagg                                                   20


<210>  1890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1890
ccccagugac ccccagccac                                                   20


<210>  1891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1891
uccauccccc cagugacccc                                                   20


<210>  1892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1892
gaauaacucc ucuccagcca                                                   20


<210>  1893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1893
cagcacuuug ggaggucaag                                                   20


<210>  1894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1894
accugccuug accucccaaa                                                   20


<210>  1895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1895
ugaggucagg aguuugagac                                                   20


<210>  1896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1896
uggccaggcu ggucucaaac                                                   20


<210>  1897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1897
uaucucuacu aaaaaaaaaa                                                   20


<210>  1898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1898
cuacuaaaaa aaaaauuagc                                                   20


<210>  1899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1899
cagguacucg gaaggcugug                                                   20


<210>  1900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1900
ugcuuuauuu uucuuccccu                                                   20


<210>  1901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1901
acuuacgaca cccauugcau                                                   20


<210>  1902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1902
ugaaagcccc ugagccuuug                                                   20


<210>  1903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1903
gugguguugg aggugcuggg                                                   20


<210>  1904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1904
uguaauggga gcugagacuc                                                   20


<210>  1905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1905
ucucucccag cucaguuucu                                                   20


<210>  1906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1906
cucccagcuc aguuucucau                                                   20


<210>  1907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1907
acauuucaua aaugagaaac                                                   20


<210>  1908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1908
uauaaaguaa gagcuacucu                                                   20


<210>  1909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1909
ucccaacaau ccuauaaagu                                                   20


<210>  1910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1910
uccauaauua cuaagaggag                                                   20


<210>  1911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1911
gucuuagucc cuuugggcug                                                   20


<210>  1912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1912
cuuagacuga guaauuuauc                                                   20


<210>  1913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1913
acagcagaag uuuauuuucu                                                   20


<210>  1914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1914
aggacuucca gccuccugac                                                   20


<210>  1915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1915
agaugccugc agauuuggug                                                   20


<210>  1916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1916
ugaucuagga cuuccagccu                                                   20


<210>  1917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1917
gcaggcaucu ugaucuagga                                                   20


<210>  1918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1918
uugaagcaga gagcagcccu                                                   20


<210>  1919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1919
uagcacuuug ggaggcugag                                                   20


<210>  1920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1920
ucccaccuca gccucccaaa                                                   20


<210>  1921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1921
cuugagccaa ggagcuagag                                                   20


<210>  1922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1922
cacuguguua cccaggcugg                                                   20


<210>  1923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1923
uucuuucuuu ucuuuucuuu                                                   20


<210>  1924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1924
cauucacgag ggcagagccu                                                   20


<210>  1925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1925
ccuccagaag gucccaccuc                                                   20


<210>  1926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1926
ccaaugcaau aguauugaga                                                   20


<210>  1927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1927
guaagcugaa acuuaauccc                                                   20


<210>  1928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1928
cccacaaauc uguaagcuga                                                   20


<210>  1929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1929
uggcccucga ugggagugga                                                   20


<210>  1930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1930
agggccagga ugcucugaau                                                   20


<210>  1931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1931
cagggacucc acagccccau                                                   20


<210>  1932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1932
gaaaauuaag uguaaugcaa                                                   20


<210>  1933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1933
guuuuauuaa uuuauuuguu                                                   20


<210>  1934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1934
guuucuugag acuccgucuc                                                   20


<210>  1935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1935
ggcccagguu ggaguacagu                                                   20


<210>  1936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1936
gccucccggg uucaagggau                                                   20


<210>  1937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1937
cuugaacccg ggaggcagau                                                   20


<210>  1938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1938
gccaccacgu ccggcuaauu                                                   20


<210>  1939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1939
uggccaacau ggugaaaccc                                                   20


<210>  1940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1940
agaccauccu ggccaacaug                                                   20


<210>  1941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1941
ccugaccucg ugauccaccc                                                   20


<210>  1942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1942
cgaggucagg agaucaagac                                                   20


<210>  1943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1943
acccaccucg gccucccaaa                                                   20


<210>  1944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1944
cagcauuuug ggaggccgag                                                   20


<210>  1945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1945
guuuuaaauu aacaaagcau                                                   20


<210>  1946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1946
cagugggcca gagucacaca                                                   20


<210>  1947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1947
aggagaggug gaggaucccc                                                   20


<210>  1948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1948
uccaccucuc cucgaugaca                                                   20


<210>  1949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1949
ccucaggcug uggcaaaaaa                                                   20


<210>  1950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1950
agugcaggua ugggggccag                                                   20


<210>  1951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1951
cccaccgcuc ucagcuccuu                                                   20


<210>  1952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1952
cuggccaacu caaaguccca                                                   20


<210>  1953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1953
gcauacuuuu cuguaaggcc                                                   20


<210>  1954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1954
ggccuuacag aaaaguaugc                                                   20


<210>  1955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1955
cuguaauaga ccugcaaagu                                                   20


<210>  1956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1956
acaccacccu uuuccacuau                                                   20


<210>  1957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1957
gaaaaagcag ggcugugcuc                                                   20


<210>  1958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1958
aucagaaaaa gcagggcugu                                                   20


<210>  1959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1959
caaaggcaaa uaagccuucc                                                   20


<210>  1960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1960
ucacaaaggc aaauaagccu                                                   20


<210>  1961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1961
cuuuagaaag uauuccucac                                                   20


<210>  1962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1962
uuucugguaa uuuuaagaau                                                   20


<210>  1963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1963
ucuuaauauu uugguauucu                                                   20


<210>  1964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1964
gagguccuua gugguauuuc                                                   20


<210>  1965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1965
ccacauuuuu augauuaauu                                                   20


<210>  1966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1966
uaaaaaugug gggauuuuua                                                   20


<210>  1967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1967
auaaauaagg ggucggcuau                                                   20


<210>  1968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1968
agcagaccuc aggaacucag                                                   20


<210>  1969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1969
aacaaauaau uuccaagcau                                                   20


<210>  1970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1970
cagcacuuug ggaggucgag                                                   20


<210>  1971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1971
acccgccucg accucccaaa                                                   20


<210>  1972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1972
cgaggucagg agauggagac                                                   20


<210>  1973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1973
ccugaccucg ugauccaccc                                                   20


<210>  1974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1974
cggcucacug caagcucagc                                                   20


<210>  1975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1975
caccacugca cuccagccug                                                   20


<210>  1976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1976
caaaaaaaga aaaaaaaaga                                                   20


<210>  1977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1977
uuucuuuuuu uuucuuuuuu                                                   20


<210>  1978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1978
aacaaaucau uucuuuuuuu                                                   20


<210>  1979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1979
agaggcucaa guggguugca                                                   20


<210>  1980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1980
aagcaagcgg cugggcugca                                                   20


<210>  1981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1981
acuucaggag gcuggaggca                                                   20


<210>  1982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1982
ggacagaaag ggggcuccag                                                   20


<210>  1983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1983
cuguuccuag ggcccugcuc                                                   20


<210>  1984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1984
gcacagcacg guuuuucucu                                                   20


<210>  1985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1985
cuauuuuuga aaaaagaaag                                                   20


<210>  1986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1986
cagcacugug ggaggccaag                                                   20


<210>  1987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1987
guuguaauaa aaaacaaaaa                                                   20


<210>  1988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1988
gcagguacag uuagcaugug                                                   20


<210>  1989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1989
cuuggggcca ggaguucaaa                                                   20


<210>  1990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1990
uccugccuug accucccaga                                                   20


<210>  1991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1991
cagcauucug ggaggucaag                                                   20


<210>  1992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1992
gcucaugccg gaggcacccg                                                   20


<210>  1993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1993
cggcacugcu guccucagag                                                   20


<210>  1994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1994
gcaggucccu ccucugggac                                                   20


<210>  1995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1995
cuccgcucag cucccugaau                                                   20


<210>  1996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1996
uccugcaggu ccacugagug                                                   20


<210>  1997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1997
cuuagugaca auucucgccc                                                   20


<210>  1998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1998
caccgcuggu ggccucuguc                                                   20


<210>  1999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  1999
uccaauacgu gcaguccacc                                                   20


<210>  2000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2000
cugaccucug uuugcaaucc                                                   20


<210>  2001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2001
auuuugcacu acggaaagga                                                   20


<210>  2002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2002
cagaaugugu ccucugaaga                                                   20


<210>  2003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2003
cagaggcugc cccuguucuu                                                   20


<210>  2004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2004
aggacguccu uacaguaaac                                                   20


<210>  2005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2005
agcaguucuc gguggugaaa                                                   20


<210>  2006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2006
cuuucaccac cgagaacugc                                                   20


<210>  2007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2007
accuggacac cgcagaugaa                                                   20


<210>  2008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2008
gcggugucca gguagauccc                                                   20


<210>  2009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2009
ccuggcagaa ugagguacug                                                   20


<210>  2010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2010
cccaaauaca cacagacaca                                                   20


<210>  2011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2011
cagcacuuug ggaggcugag                                                   20


<210>  2012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2012
gccugccuca gccucccaaa                                                   20


<210>  2013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2013
ugaggucagg aguucgagac                                                   20


<210>  2014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2014
cuacuagcug ggacuacagg                                                   20


<210>  2015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2015
cuugaaccug ggaggcagaa                                                   20


<210>  2016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2016
cagcucacug caacuucugc                                                   20


<210>  2017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2017
uuuuuuuuuu uuuuuugggu                                                   20


<210>  2018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2018
gcagcugucc agaagcacag                                                   20


<210>  2019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2019
gacccaaaau agcuaccucc                                                   20


<210>  2020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2020
gcaugcacag aauaacagga                                                   20


<210>  2021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2021
ucugcaugca cagaauaaca                                                   20


<210>  2022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2022
aaucugggug uuucaaagac                                                   20


<210>  2023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2023
ggguguuuca aagacaucaa                                                   20


<210>  2024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2024
acaaaaguga aagugaggaa                                                   20


<210>  2025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2025
aauggcaaag cuuccucacu                                                   20


<210>  2026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2026
agacaagaac auacauaccc                                                   20


<210>  2027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2027
caaacagaaa aaguaccagg                                                   20


<210>  2028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2028
cagcaacaaa ccucacugcg                                                   20


<210>  2029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2029
gaacagucuu caucccagca                                                   20


<210>  2030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2030
aaaacaggac uaccuuccag                                                   20


<210>  2031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2031
gcauccugug gaaccuucgu                                                   20


<210>  2032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2032
uguggaaccu ucgucagaug                                                   20


<210>  2033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2033
gacgaagguu ccacaggaug                                                   20


<210>  2034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2034
cucccugcuc uggcucuuag                                                   20


<210>  2035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2035
acuuuccccg ugcagcgggc                                                   20


<210>  2036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2036
uggcugggug cgguggcuca                                                   20


<210>  2037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2037
cagcacuuug ggaggccgag                                                   20


<210>  2038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2038
accugccucg gccucccaaa                                                   20


<210>  2039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2039
ccugagguca ggaguuugag                                                   20


<210>  2040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2040
cgugaaccca ggagguggag                                                   20


<210>  2041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2041
cggcucacug cacccuccac                                                   20


<210>  2042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2042
ugccacugua cuccagccug                                                   20


<210>  2043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2043
caaaaagaaa gaaagaaaaa                                                   20


<210>  2044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2044
uuuggaaaga cuuucuguaa                                                   20


<210>  2045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2045
aaggagagac acuuugcaug                                                   20


<210>  2046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2046
uacuuugcac ccuguguguu                                                   20


<210>  2047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2047
acccccuggg aacacacagg                                                   20


<210>  2048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2048
aucuuucuuu caguaugaaa                                                   20


<210>  2049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2049
uucuuucagu augaaaaaua                                                   20


<210>  2050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2050
cagcacuuug ggaggcugag                                                   20


<210>  2051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2051
acccuccuca gccucccaaa                                                   20


<210>  2052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2052
ccugagguca ggaguucaag                                                   20


<210>  2053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2053
cuacuaaaaa uauaaaaauu                                                   20


<210>  2054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2054
cagcuaccug ggagucugag                                                   20


<210>  2055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2055
cuugaaccug ggaggcggag                                                   20


<210>  2056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2056
caaaguggca uuucccaugg                                                   20


<210>  2057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2057
ccaagugugg acacugggac                                                   20


<210>  2058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2058
gauugcacag agugaagccc                                                   20


<210>  2059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2059
gauucucuca acggcagguu                                                   20


<210>  2060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2060
accacaucau gaaguaaaua                                                   20


<210>  2061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2061
ugaaguaaau aaggagaaaa                                                   20


<210>  2062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2062
cagcacuuug ggaggcugag                                                   20


<210>  2063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2063
ucccaccuca gccucccaaa                                                   20


<210>  2064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2064
cuugagauca ggaguucgag                                                   20


<210>  2065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2065
caagugaucc ucccaccuca                                                   20


<210>  2066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2066
ggaguucgag agcaaccugg                                                   20


<210>  2067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2067
cuacaaccuc caccuuccag                                                   20


<210>  2068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2068
gagauccugc cauugcacuc                                                   20


<210>  2069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2069
cagaucacua caaccuccac                                                   20


<210>  2070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2070
ugccauugca cuccagccug                                                   20


<210>  2071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2071
gccgugugcc ugaggccgcc                                                   20


<210>  2072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2072
aaauaaaaca ugccuuggga                                                   20


<210>  2073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2073
agcuuuagug aaaagacaac                                                   20


<210>  2074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2074
auucccaagc ccccgcuggc                                                   20


<210>  2075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2075
cuggccgagu ggugagacca                                                   20


<210>  2076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2076
cccgauggcu gucccguugc                                                   20


<210>  2077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2077
ggagaugcag gaaugccaac                                                   20


<210>  2078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2078
cggugagggg cacaaggcaa                                                   20


<210>  2079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2079
aucugcccuu gaaaggggcg                                                   20


<210>  2080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2080
gcccuugaaa ggggcggcuc                                                   20


<210>  2081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2081
cugacacagu accggccucu                                                   20


<210>  2082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2082
ucaugcccug gcacacgcac                                                   20


<210>  2083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2083
gggcgcagcu ucaaggccgc                                                   20


<210>  2084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2084
uuagagaagg ugcggaacuu                                                   20


<210>  2085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2085
ugcgaagcac aguucaggaa                                                   20


<210>  2086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2086
auucuccacu gcugucaggg                                                   20


<210>  2087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2087
cggcugcagg cuccaggcag                                                   20


<210>  2088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2088
cugugcugcc ugcugcguga                                                   20


<210>  2089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2089
gacagcugcg cgcgggagag                                                   20


<210>  2090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2090
gggugugggg aaaaucagcu                                                   20


<210>  2091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2091
gcuuccgcag gugcccaccg                                                   20


<210>  2092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2092
ccgcuggugu uuuccuccca                                                   20


<210>  2093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2093
uggagacuug gggucuuuau                                                   20


<210>  2094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2094
gaagaaaagc aaagcuauuu                                                   20


<210>  2095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2095
ucauucugca gcugaggaca                                                   20


<210>  2096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2096
cgggggcacc aacuccugcc                                                   20


<210>  2097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2097
uguagcacag uguugaauac                                                   20


<210>  2098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2098
ugggaaaaua auaccugcuc                                                   20


<210>  2099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2099
ccauuauucc acccccaccc                                                   20


<210>  2100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2100
guguagacaa aguccacagc                                                   20


<210>  2101
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2101
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  2102
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2102
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcu cgacgcgucc ucgagcagaa gcaucaaag                              99


<210>  2103
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2103
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcu cgcuccguuc gagcagaagc aucaaag                                97


<210>  2104
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2104
guacuggcgc uuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcccu cuucggaggg aagcaucaaa g                                      91


<210>  2105
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2105
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcagga guuucuaugg aaacccugaa gcaucaaag                              99


<210>  2106
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2106
guacuggcgc cuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2107
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2107
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcg cuugcgcaga agcaucaaag                                        90


<210>  2108
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2108
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2109
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2109
uacuggcgcu uuuaucgcau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2110
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2110
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga cuucgguccg auaaauaaga agcaucaaag                 110


<210>  2111
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2111
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcacau gaggauuacc caugugaagc aucaaag                                97


<210>  2112
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2112
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucgugaga aauccgauaa auaagaagca ucaaag                     106


<210>  2113
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2113
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugca ugucuaagac agcagaagca ucaaag                                 96


<210>  2114
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2114
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggg cuucggccga agcaucaaag                                        90


<210>  2115
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2115
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaauc cauugcacuc cggauugaag caucaaag                               98


<210>  2116
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2116
uacuggcgcu uuucucgcau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2117
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2117
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggacu ucgguccgau aaauaagaag caucaaag                   108


<210>  2118
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2118
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcu cguuugcggc uacgagcaga agcaucaaag                            100


<210>  2119
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2119
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgagag auaaauaaga agcaucaaag                            100


<210>  2120
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2120
uacggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggagag aaauccgaua aauaagaagc aucaaag                    107


<210>  2121
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2121
uacuggcgcc uuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2122
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2122
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaucggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2123
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2123
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggacu ucgguccgau aaauaagaag caucaaag                   108


<210>  2124
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2124
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgagaa auccgauaaa uaagaagcau caaag                      105


<210>  2125
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2125
gcgcuuuuau cucauuacuu ugagagccau caccagcgac uaugucguau ggguaaagcg       60

cuuauuuauc ggagagaaau ccgauaaaua agaagcauca aag                        103


<210>  2126
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2126
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gagauaaaua agaagcauca aag                        103


<210>  2127
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2127
uacuggcgcu uuuaucucau uacuuuggag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua uuuaucggag aguauccgau aaauaagaag caucaaag                   108


<210>  2128
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2128
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2129
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2129
agcgcuuuua ucucauuacu uugagagcca ucaccagcga cuaugucgua uggguaaagc       60

gcuuauuuau cggagagaaa ugccgauaaa uaagaagcau caaag                      105


<210>  2130
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2130
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaaauaagaa gcaucaaag                  109


<210>  2131
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2131
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uguaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2132
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2132
gcgcuuuuau cucauuacuu ugagagccau caccagcgac uaugucguau ggguaaagcg       60

cuuauuuauc ggacuucggu ccgauaaaua agcgcaucaa ag                         102


<210>  2133
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2133
uacuggcgcu uuucucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2134
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2134
guggcgcuuu uaucucauua cuuugagagc caucaccagc gacuaugucg uauggguaaa       60

gcgcuuauuu aucggagaga aauccgauaa auaagaagca ucaaag                     106


<210>  2135
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2135
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgaccuuau gucguauggg       60

uaaagcgcuu auuuaucgga gagaaauccg auaaauaaga agcaucaaag                 110


<210>  2136
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2136
gauggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggacuu cgguccgaua aauaagaagc aucaaag                    107


<210>  2137
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2137
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaaagaagca ucaaag                     106


<210>  2138
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2138
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgaucuaug ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2139
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2139
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aaggcuuauu uaucggagag aaauccgaua aaaagaagca ucaaag                     106


<210>  2140
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2140
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaaaagaagc aucaaag                    107


<210>  2141
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2141
uacuggcgcu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggacuu cgguccgaua aauaagaagc aucaaag                    107


<210>  2142
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2142
cggcgcuuuu cucgcauuac uuugagagcc aucaccagcg acuaugucgu auggguaaag       60

cgcuuauugu aucgagagau aaauaagaag caucaaag                               98


<210>  2143
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2143
cacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuucggagag aaauccgaua aauaagaagc aucaaag                    107


<210>  2144
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2144
uacuggcgcu uuaucucauu acuuugagag ccaucaccag cgacuucggu cguaugggua       60

aagcgcuuau guaucggcuu cggccgauac auaagaagca ucaaag                     106


<210>  2145
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2145
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuucgg ucguaugggu       60

aaagcgcuua uguaucggcu ucggccgaua cauaagaagc aucaaag                    107


<210>  2146
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2146
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggug       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2147
<211>  64
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2147
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuucgg ucguaugggu       60

aaag                                                                    64


<210>  2148
<211>  62
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2148
gaugggcuuu uaucucauua cuuugagagc caucaccagc gacuucgguc guauggguaa       60

ag                                                                      62


<210>  2149
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2149
gaugggcuuu uaucucauua cuuugagagc caucaccagc gacuucgguc guauggguaa       60

agcgcuuauu uaucggcuuc ggccgauaaa uaagaagcau caaag                      105


<210>  2150
<211>  156
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2150
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuaca cugggaucgc ugaauuagag aucggcgucc uuucauucua uauacuuugg      120

aguuuuaaaa ugucucuaag uacagaagca ucaaag                                156


<210>  2151
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2151
ggcgcuuuua ucucauuacu uugagagcca ucaccagcga cuucggucgu auggguaaag       60

cgcuuauuua ucggcuucgg ccgauaaaua agaagcauca aag                        103


<210>  2152
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2152
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuucggu cguaugggua       60

aagcgcuuau uuaucggcuu cggccgauaa auaagaagca ucaaag                     106


<210>  2153
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2153
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuucgg ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2154
<211>  112
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2154
uacuggcgcu uuuaucucau uacuuugaga gccaugcucc accagcgacu augucguaug       60

gguaaagcgc uuauuuaucg gagagaaauc cgauaaauaa gaagcaucaa ag              112


<210>  2155
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2155
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgggguu aggguuaggg uuagggaagc aucaaag                                97


<210>  2156
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2156
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcggaggg agggagggag agggaaagca ucaaag                                 96


<210>  2157
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2157
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcguuggg uuaggguuag gguuagggaa aagcaucaaa g                          101


<210>  2158
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2158
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggg cuucggccgg aagcaucaaa g                                      91


<210>  2159
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2159
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgccugc ucaguacgag aggaaccgca ggaagcauca aag                        103


<210>  2160
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2160
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcccuc uucggaggga agcaucaaag                                        90


<210>  2161
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2161
uacuggcgcc uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2162
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2162
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  2163
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2163
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  2164
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2164
uacuggcgcc uuuaucugca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2165
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2165
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2166
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2166
uacuggcgcc uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  2167
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2167
uacuggcgcc uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  2168
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2168
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcccuc uucggaggga agcaucaaag                                        90


<210>  2169
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2169
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2170
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2170
uacuggcgcc uuuaucauca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2171
<211>  194
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2171
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg ccggcauggu      120

cccagccucc ucgcuggcgc cggcugggca acauuccgag gggaccgucc ccucgguaau      180

ggcgaauggg accc                                                        194


<210>  2172
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2172
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  2173
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2173
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga aauccgauaa auaagaagca ucaaag                     106


<210>  2174
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2174
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  2175
<211>  92
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2175
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgccgga cuucgguccg gaagcaucaa ag                                     92


<210>  2176
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2176
uacuggcgcu uuuaucggau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2177
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2177
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  2178
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2178
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  2179
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2179
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucccucu ucggagggag caucaaag                                          88


<210>  2180
<211>  197
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2180
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg gucggcaugg      120

caucuccacc uccucgcggu ccgaccuggg cauccgaagg aggacgcacg uccacucgga      180

uggcuaaggg agagcca                                                     197


<210>  2181
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2181
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggcg caucaaag                                          88


<210>  2182
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2182
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaguu uuggccggca      120

uggucccagc cuccucgcug gcgccggcug ggcaacaugc uucggcaugg cgaaugggac      180

cccggg                                                                 186


<210>  2183
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2183
gauggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2184
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2184
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  2185
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2185
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucuuacg gacuucgguc cguaagagca ucaaag                                 96


<210>  2186
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2186
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucggacg accucucggu cguccgagca ucaaag                                 96


<210>  2187
<211>  160
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2187
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcc ugucaccgga      120

ugugcuuucc ggucugauga guccgugagg acgaaacagg                            160


<210>  2188
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2188
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  2189
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2189
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  2190
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2190
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucaggug ggacgaccuc ucggucgucc uaucugagca ucaaag                     106


<210>  2191
<211>  177
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2191
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagga uggccggcau      120

ggucccagcc uccucgcugg cgccggcugg gcaacaccuu cggguggcga augggac         177


<210>  2192
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2192
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  2193
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2193
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguacugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2194
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2194
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgugag aaauccgaua aauaagaagc aucaaag                    107


<210>  2195
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2195
guacuggcgc uuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2196
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2196
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  2197
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2197
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2198
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2198
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggagag aaauccgaua aauaagaagc aucaaag                    107


<210>  2199
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2199
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2200
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2200
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  2201
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2201
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  2202
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2202
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  2203
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2203
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  2204
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2204
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2205
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2205
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  2206
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2206
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2207
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2207
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  2208
<211>  177
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2208
gauggccggc auggucccag ccuccucgcu ggcgccggcu gggcaacacc uucggguggc       60

gaaugggacu acuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc      120

guauggguaa agcgcuuauu uaucggagag aaauccgaua aauaagaagc aucaaag         177


<210>  2209
<211>  194
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2209
ggccggcaug gucccagccu ccucgcuggc gccggcuggg caacauuccg aggggaccgu       60

ccccucggua auggcgaaug ggacccuacu ggcgcuuuua ucucauuacu uugagagcca      120

ucaccagcga cuaugucgua uggguaaagc gcuuauuuau cggagagaaa uccgauaaau      180

aagaagcauc aaag                                                        194


<210>  2210
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2210
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagcgca ucaaag                                 96


<210>  2211
<211>  172
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2211
cgugguuagg gccacguuaa auaguugcuu aagcccuaag cguugaucuu cggaucaggu       60

gcaauacugg cgcuuuuauc ucauuacuuu gagagccauc accagcgacu augucguaug      120

gguaaagcgc uuauuuaucg gagagaaauc cgauaaauaa gaagcaucaa ag              172


<210>  2212
<211>  197
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2212
gggucggcau ggcaucucca ccuccucgcg guccgaccug ggcauccgaa ggaggacgca       60

cguccacucg gauggcuaag ggagagccau acuggcgcuu uuaucucauu acuuugagag      120

ccaucaccag cgacuauguc guauggguaa agcgcuuauu uaucggagag aaauccgaua      180

aauaagaagc aucaaag                                                     197


<210>  2213
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2213
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcc aguacugaug      120

aguccgugag gacgaaacga guaagcucgu cuacuggcgc uuuuaucuca u               171


<210>  2214
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2214
uacuggcgcc uuuaucucau uacuuuagag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2215
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2215
cgacuacuga ugaguccgug aggacgaaac gaguaagcuc gucuagucgu acuggcgcuu       60

uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa agcgcuuauu      120

uaucggagag aaauccgaua aauaagaagc aucaaag                               157


<210>  2216
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2216
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugcgca ucaaag                     106


<210>  2217
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2217
uacuggcgcc uuuaucucau uacuuuagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2218
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2218
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagca uuccucagaa      120

aaugacaaac cuguggggcg uaaguagauc uucggaucua ugaucgugca gacguuaaaa      180

ucaggu                                                                 186


<210>  2219
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2219
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcg acuacugaug      120

aguccgugag gacgaaacga guaagcucgu cuagucgcgu guagcgaagc a               171


<210>  2220
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2220
cauuccucag aaaaugacaa accugugggg cguaaguaga ucuucggauc uaugaucgug       60

cagacguuaa aaucagguua cuggcgcuuu uaucucauua cuuugagagc caucaccagc      120

gacuaugucg uauggguaaa gcgcuuauuu aucggagaga aauccgauaa auaagaagca      180

ucaaag                                                                 186


<210>  2221
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2221
uuuuggccgg caugguccca gccuccucgc uggcgccggc ugggcaacau gcuucggcau       60

ggcgaauggg accccgggua cuggcgcuuu uaucucauua cuuugagagc caucaccagc      120

gacuaugucg uauggguaaa gcgcuuauuu aucggagaga aauccgauaa auaagaagca      180

ucaaag                                                                 186


<210>  2222
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2222
cgacuacuga ugaguccgug aggacgaaac gaguaagcuc gucuagucgc guguagcgaa       60

gcauacuggc gcuuuuaucu cauuacuuug agagccauca ccagcgacua ugucguaugg      120

guaaagcgcu uauuuaucgg agagaaaucc gauaaauaag aagcaucaaa g               171


<210>  2223
<211>  168
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2223
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg gagccccgcu      120

gaugaggucg gggagaccga aagggacuuc ggucccuacg gggcuccc                   168


<210>  2224
<211>  144
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2224
ccacccccac caccaccccc acccccacca ccacccuacu ggcgcuuuua ucucauuacu       60

uugagagcca ucaccagcga cuaugucgua uggguaaagc gcuuauuuau cggagagaaa      120

uccgauaaau aagaagcauc aaag                                             144


<210>  2225
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2225
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcg acuacugaug      120

aguccgugag gacgaaacga guaagcucgu cuagucg                               157


<210>  2226
<211>  172
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2226
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcg ugguuagggc      120

cacguuaaau aguugcuuaa gcccuaagcg uugaucuucg gaucaggugc aa              172


<210>  2227
<211>  184
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2227
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg caauaaagcg      120

guuacaagcc cgcaaaaaua gcagaguaau gucgcgauag cgcggcauua augcagcuuu      180

auug                                                                   184


<210>  2228
<211>  122
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2228
uacuggcgcu uuuaucucau uacuauuauc ucauuacuuu gagagccauc accagcgacu       60

augucguaug gguaaagcgc uuauuuaucg gagagaaauc cgauaaauaa gaagcaucaa      120

ag                                                                     122


<210>  2229
<211>  184
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2229
ggcaauaaag cgguuacaag cccgcaaaaa uagcagagua augucgcgau agcgcggcau       60

uaaugcagcu uuauuguacu ggcgcuuuua ucucauuacu uugagagcca ucaccagcga      120

cuaugucgua uggguaaagc gcuuauuuau cggagagaaa uccgauaaau aagaagcauc      180

aaag                                                                   184


<210>  2230
<211>  185
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2230
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagac ccgcaaggcc      120

gacggcaucc gccgccgcug gugcaagucc agccgccccu ucgggggcgg gcgcucaugg      180

guaac                                                                  185


<210>  2231
<211>  63
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2231
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aag                                                                     63


<210>  2232
<211>  168
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2232
gggagccccg cugaugaggu cggggagacc gaaagggacu ucggucccua cggggcuccc       60

uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua      120

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   168


<210>  2233
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2233
ccaguacuga ugaguccgug aggacgaaac gaguaagcuc gucuacuggc gcuuuuaucu       60

cauuacuggc gcuuuuaucu cauuacuuug agagccauca ccagcgacua ugucguaugg      120

guaaagcgcu uauuuaucgg agagaaaucc gauaaauaag aagcaucaaa g               171


<210>  2234
<211>  185
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2234
acccgcaagg ccgacggcau ccgccgccgc uggugcaagu ccagccgccc cuucgggggc       60

gggcgcucau ggguaacuac uggcgcuuuu aucucauuac uuugagagcc aucaccagcg      120

acuaugucgu auggguaaag cgcuuauuua ucggagagaa auccgauaaa uaagaagcau      180

caaag                                                                  185


<210>  2235
<211>  160
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2235
ccugucaccg gaugugcuuu ccggucugau gaguccguga ggacgaaaca gguacuggcg       60

cuuuuaucuc auuacuuuga gagccaucac cagcgacuau gucguauggg uaaagcgcuu      120

auuuaucgga gagaaauccg auaaauaaga agcaucaaag                            160


<210>  2236
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2236
guacuggcgc cuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaguggg       60

uaaagcgcuu acggacuucg guccguaaga agcaucaaag                            100


<210>  2237
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2237
guacuggcgc uuuuaucuga uuacuuugag agccaucacc agcgacuaug ucguaguggg       60

uaaagcuccc ucuucggagg gagcaucaaa g                                      91


<210>  2238
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2238
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2239
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2239
acuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2240
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2240
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2241
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2241
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucccucu ucggagggag caucaaag                                          88


<210>  2242
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2242
acuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2243
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2243
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2244
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2244
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2245
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2245
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2246
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2246
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2247
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2247
acuggcgccu uuaucaucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2248
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2248
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcgcccuc uucggaggga agcaucaaag                                        90


<210>  2249
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2249
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaucacc caugugagca ucaaag                                 96


<210>  2250
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2250
acuggcacuu uuaccugauu acuuugagag ccaacaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2251
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2251
acuggcacuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2252
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2252
acuggcccuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2253
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2253
acuggcgcuu uuaccugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2254
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2254
acuggcgcuu uuaucugauu acuuugagag ccaacaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2255
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2255
acuggcaccu uuaccugauu acuuugagag ccaacaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2256
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2256
acuggcaccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2257
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2257
acuggccccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2258
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2258
acuggcgccu uuaucugauu acuuugagag ccaacaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2259
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2259
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2260
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2260
gacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2261
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2261
acuggcgccu uuaucugauu acuuuggaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2262
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2262
acuggcgcau uuaucugauu acuuugugag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2263
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2263
acuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2264
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2264
acuggcgcuu uuaucugauu acuuuggaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2265
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2265
acuggcgcau uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2266
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2266
acuggcgcuu uuaucugauu acuuugugag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2267
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2267
acuggcgcuu uuauucugau uacuuugaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2268
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2268
acggcgcuuu uaucugauua cuuugagagc caucaccagc gacuaugucg uaguggguaa       60

agcucccucu ucggagggag caucaaag                                          88


<210>  2269
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2269
acuggcgcuu uuauaugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2270
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2270
acuggcgcuu uuaucuugau uacuuugaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2271
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2271
acuggcgcuu uuaucugauu acuuugagag ccagcaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2272
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2272
acuggcgcug uuaucugauu acuucgagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucgaag                                         89


<210>  2273
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2273
acuggcgcuc uuaucugauu acuucgagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucgaag                                         89


<210>  2274
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2274
acuggcgcuu guaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  2275
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2275
acuggcgcuu cuaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  2276
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2276
acuggcgcuu ugaucugauu accuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaagg                                         89


<210>  2277
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2277
acuggcgcuu ucaucugauu accuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaagg                                         89


<210>  2278
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2278
acuggcgcug uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2279
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2279
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucgaag                                         89


<210>  2280
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2280
acuggcgcuu uuaucugauu acuucgagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2281
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2281
acuggcacuu cuaucugauu acucugagag ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  2282
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2282
acuggcacuu cuaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  2283
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2283
acuggcaccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucaaag                               98


<210>  2284
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2284
acuggcacuu guaucugauu acucugagag ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  2285
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  2285
acuggcacuu guaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  2286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2286
caguguagac gacucugcug                                                   20


<210>  2287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2287
ugaauggggg cuggguaaaa                                                   20


<210>  2288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2288
uguaacuaag aaugccuaac                                                   20


<210>  2289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2289
cauccuguaa cuaagaaugc                                                   20


<210>  2290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2290
gcaagcucuu ugggaccugu                                                   20


<210>  2291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2291
cagcacuuug ggaggccgag                                                   20


<210>  2292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2292
accugccucg gccucccaaa                                                   20


<210>  2293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2293
cuugaggcca ggaguuagag                                                   20


<210>  2294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2294
cugcaccugg cuaauuuuug                                                   20


<210>  2295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2295
aucacugcac cuggcuaauu                                                   20


<210>  2296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2296
cuugaaccca ggagucagag                                                   20


<210>  2297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2297
ucucaaaaaa aauaauaaaa                                                   20


<210>  2298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2298
ugguuuuggu ggguuuccca                                                   20


<210>  2299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2299
ccaucuuggu uuuggugggu                                                   20


<210>  2300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2300
ucacagcuca uuacaugcua                                                   20


<210>  2301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2301
gcgccaugac aguuuucaga                                                   20


<210>  2302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2302
gaaaacuguc auggcgcuga                                                   20


<210>  2303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2303
cccaccccuu ucccagaaau                                                   20


<210>  2304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2304
caugaauaau ccaccccuug                                                   20


<210>  2305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2305
accccuuguu uagcauauaa                                                   20


<210>  2306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2306
agaaauaacc auaaaaaugg                                                   20


<210>  2307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2307
auaaagggaa agcaaguuuc                                                   20


<210>  2308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2308
cgcucaggaa acaauucgag                                                   20


<210>  2309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2309
aaguacccuc uuuugggguc                                                   20


<210>  2310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2310
agaccccaaa agaggguacu                                                   20


<210>  2311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2311
ggaccccugu ccaguagcac                                                   20


<210>  2312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2312
ugccugcuga ggaggaaacu                                                   20


<210>  2313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2313
uucauacccu gggcuggugg                                                   20


<210>  2314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2314
uggccuaggu uuauuucucu                                                   20


<210>  2315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2315
cauuuuucuc uuucuguuua                                                   20


<210>  2316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2316
uuccaguuuu aguguauaug                                                   20


<210>  2317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2317
ucucuguauc auuccaguuu                                                   20


<210>  2318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2318
cgucuuuaau auuagcugcu                                                   20


<210>  2319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2319
guaucaacau uuuguuugcu                                                   20


<210>  2320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2320
acauuuuguu ugcuauuuau                                                   20


<210>  2321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2321
cuauauuaau uauauaaaua                                                   20


<210>  2322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2322
cgccaccgca cuccagccug                                                   20


<210>  2323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2323
cggcucacug caaccugcau                                                   20


<210>  2324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2324
cuugaaugca gguugcagug                                                   20


<210>  2325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2325
gggaagcuga ggcaugagaa                                                   20


<210>  2326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2326
cagcuauccg ggaagcugag                                                   20


<210>  2327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2327
guacuaaaaa aaaaaaauua                                                   20


<210>  2328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2328
gcccaucuca gccucccaaa                                                   20


<210>  2329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2329
cagccuccca aaggauuaca                                                   20


<210>  2330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2330
uuugggaggc ugagaugggc                                                   20


<210>  2331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2331
uuuauuacau auuucaguca                                                   20


<210>  2332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2332
augauauugu gaaguuauau                                                   20


<210>  2333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2333
uggaugacug aaauauguaa                                                   20


<210>  2334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2334
uuggaaucuu caaagugaug                                                   20


<210>  2335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2335
ucaaagugau gaaugucuuu                                                   20


<210>  2336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2336
cuuugaagau uccaaggauu                                                   20


<210>  2337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2337
ugaagcuguc uaggagccac                                                   20


<210>  2338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2338
gccccucucc cuucccagag                                                   20


<210>  2339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2339
gcucaaccau cagccccucu                                                   20


<210>  2340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2340
ccaauggcua augauuaaau                                                   20


<210>  2341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2341
uuagccauug gcgaucagcu                                                   20


<210>  2342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2342
ugccuaugug augaagccuc                                                   20


<210>  2343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2343
cauaggcaug auuuaaucau                                                   20


<210>  2344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2344
ucucaucugg cuguucaucu                                                   20


<210>  2345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2345
ggcuguucau cuguauccug                                                   20


<210>  2346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2346
guauccugua aaauaugccu                                                   20


<210>  2347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2347
uguaaaauau gccuuguaau                                                   20


<210>  2348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2348
gcauacagaa cucagagaaa                                                   20


<210>  2349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2349
agcaaauuaa uugaacccaa                                                   20


<210>  2350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2350
caggccaaau aaccaggggc                                                   20


<210>  2351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2351
aggacucagu ucccacaaga                                                   20


<210>  2352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2352
guguggucag gcgcugucua                                                   20


<210>  2353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2353
accuguagac agcgccugac                                                   20


<210>  2354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2354
guucugcagc ggacaccagc                                                   20


<210>  2355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2355
acacagaaua cuucucccca                                                   20


<210>  2356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2356
aggggaaaag cgcagugucc                                                   20


<210>  2357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2357
ucaggguggc ugaauauaca                                                   20


<210>  2358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2358
gugaggggag caacacccag                                                   20


<210>  2359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2359
cgcuaacccc aacauuuuuu                                                   20


<210>  2360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2360
gaggaugugg uuuuccuccc                                                   20


<210>  2361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2361
uccgaucacg cuaaccccaa                                                   20


<210>  2362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2362
gaggccacgg ccaggcaaug                                                   20


<210>  2363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2363
ucugaggcca cggccaggca                                                   20


<210>  2364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2364
cacucuucua uugccuuuag                                                   20


<210>  2365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2365
uaaaaccccu gccaacugag                                                   20


<210>  2366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2366
caucauaauu uuuuuuuuaa                                                   20


<210>  2367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2367
uaauuuuuuu uuuaacaaaa                                                   20


<210>  2368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2368
uucauugcuc aauuaaacuc                                                   20


<210>  2369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2369
cagcagauuc agagggacuc                                                   20


<210>  2370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2370
gcugugauuc ugggggcugc                                                   20


<210>  2371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2371
cuggaguccc ucugaaucug                                                   20


<210>  2372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2372
auagacaaaa aagggaagug                                                   20


<210>  2373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2373
cagcagccgu acuucacucg                                                   20


<210>  2374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2374
ucacuuggga gucugcaccu                                                   20


<210>  2375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2375
cucaaaauug agaaaaugac                                                   20


<210>  2376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2376
augacuaaag uuuuggucaa                                                   20


<210>  2377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2377
ccaucguaaa uguacuuauu                                                   20


<210>  2378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2378
uaaauguacu uauuuggucc                                                   20


<210>  2379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2379
guuaggaucu auguguuucc                                                   20


<210>  2380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2380
uaacagauuc cccuauaaac                                                   20


<210>  2381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2381
auguguuucc uuaaagucuu                                                   20


<210>  2382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2382
aacuaagacu uuaaggaaac                                                   20


<210>  2383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2383
cagcacuuug ggaggccgag                                                   20


<210>  2384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2384
gcccaccucg gccucccaaa                                                   20


<210>  2385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2385
ugaggucagg agaucgagac                                                   20


<210>  2386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2386
ccugaccuca ugaucugccc                                                   20


<210>  2387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2387
agaccauccu ggcuaacacg                                                   20


<210>  2388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2388
uggcuaacac ggugaaaccc                                                   20


<210>  2389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2389
cggcucacug caagcuccgc                                                   20


<210>  2390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2390
auuucuagua uaacuauucu                                                   20


<210>  2391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2391
auaaucuauu ucuaguauaa                                                   20


<210>  2392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2392
uaucuauaau cuauuucuag                                                   20


<210>  2393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2393
aaucauaucu auaaucuauu                                                   20


<210>  2394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2394
aucauuaguu uguggcauua                                                   20


<210>  2395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2395
uuaguuugug gcauuacucu                                                   20


<210>  2396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2396
uuguucuaca auuauaaccu                                                   20


<210>  2397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2397
cuguauggcc ugguuuuucc                                                   20


<210>  2398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2398
cuuguggaag gccugacauc                                                   20


<210>  2399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2399
gucaggcccg cccacagcca                                                   20


<210>  2400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2400
ggaggccuga ccaucucccu                                                   20


<210>  2401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2401
cccugugaug cugugcuuca                                                   20


<210>  2402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2402
cagggagaug gucaggccuc                                                   20


<210>  2403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2403
ucuagauagc aguagcagaa                                                   20


<210>  2404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2404
agaagaugga gccaggugua                                                   20


<210>  2405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2405
uuggagauga cucacacucc                                                   20


<210>  2406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2406
ccaaugauag gucaggucac                                                   20


<210>  2407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2407
aauaaguaac agggcagcca                                                   20


<210>  2408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2408
cuuugucuug uguccuuauu                                                   20


<210>  2409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2409
cagaaauaag gacacaagac                                                   20


<210>  2410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2410
cucaucuccg caggugagga                                                   20


<210>  2411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2411
ccgcagguga ggagaaaaac                                                   20


<210>  2412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2412
uuuuggguuu cuggucucag                                                   20


<210>  2413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2413
cuagaacaac aaauggucuc                                                   20


<210>  2414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2414
uaauaauagu cucccuggug                                                   20


<210>  2415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2415
ucccaguaau cauaauaaua                                                   20


<210>  2416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2416
aauagaucag acaaugagcu                                                   20


<210>  2417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2417
auuugauuug gggugguuug                                                   20


<210>  2418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2418
gacaaugagc uagauaagag                                                   20


<210>  2419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2419
agcucauugu cugaucuauu                                                   20


<210>  2420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2420
cccacaacug aaucucuaua                                                   20


<210>  2421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2421
cuauaauacc ugauguauuu                                                   20


<210>  2422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2422
gguauuauag agauucaguu                                                   20


<210>  2423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2423
ugagggauac auuucugguu                                                   20


<210>  2424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2424
cucaugauag gcuguauagc                                                   20


<210>  2425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2425
cuuuuccaug guuuagagua                                                   20


<210>  2426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2426
guucacuccu cuuaacccac                                                   20


<210>  2427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2427
gucagaaaca gaauaucggu                                                   20


<210>  2428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2428
uuuaucuauc aaaguauaaa                                                   20


<210>  2429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2429
aucaaaguau aaaguuaucc                                                   20


<210>  2430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2430
aaguauaaag uuauccgugu                                                   20


<210>  2431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2431
guguauaagg cuggcugcaa                                                   20


<210>  2432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2432
uucacaaaug aaaguauacc                                                   20


<210>  2433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2433
guugugugca cuuauggggu                                                   20


<210>  2434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2434
ucuuuucauu ucuauuauuc                                                   20


<210>  2435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2435
guuccuugcu uaugccucua                                                   20


<210>  2436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2436
uugaguaucu guuccuugcu                                                   20


<210>  2437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2437
cagcacuuug ggaggccgag                                                   20


<210>  2438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2438
gcccaccucg gccucccaaa                                                   20


<210>  2439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2439
ccugagguua gaaguucaaa                                                   20


<210>  2440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2440
cuacuaaaaa uacaaaaauu                                                   20


<210>  2441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2441
cuugaaccca ggaggcagag                                                   20


<210>  2442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2442
ccaaaaaaga aaaaaaaaag                                                   20


<210>  2443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2443
agacuucuac ugucaugaga                                                   20


<210>  2444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2444
acgaucuuag caaaagccgu                                                   20


<210>  2445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2445
uggaucaaga cuucuacugu                                                   20


<210>  2446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2446
uagcaaaagc cguucacauc                                                   20


<210>  2447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2447
aggaugccau cuucugggga                                                   20


<210>  2448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2448
uugaugugaa cggcuuuugc                                                   20


<210>  2449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2449
ucuggggaga gacuuccuug                                                   20


<210>  2450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2450
acacuccugg aacuguacac                                                   20


<210>  2451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2451
cacaacugag aaggguccau                                                   20


<210>  2452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2452
ugaaacuugg guucauaauc                                                   20


<210>  2453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2453
cuaaguuuug uugcagugcg                                                   20


<210>  2454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2454
gcacugcaac aaaacuuagg                                                   20


<210>  2455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2455
gagaaagacu guccuugcca                                                   20


<210>  2456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2456
ucugagaaca ucagagaaag                                                   20


<210>  2457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2457
agucuucggg uucuagaaug                                                   20


<210>  2458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2458
gcccucuuaa caugcgagag                                                   20


<210>  2459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2459
ucauuuucaa ugcauguuuu                                                   20


<210>  2460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2460
cuuuauaaaa uauguaaaua                                                   20


<210>  2461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2461
cacacacaca cacacacaca                                                   20


<210>  2462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2462
caaaaaaaaa aaaguguaua                                                   20


<210>  2463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2463
cugucaccca ggcuggagug                                                   20


<210>  2464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2464
cggcucacuc caaccucugc                                                   20


<210>  2465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2465
aaauuaaaua cauuggugug                                                   20


<210>  2466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2466
uuuccaugau gagucacgaa                                                   20


<210>  2467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2467
uggaaaagau aaaguaaucc                                                   20


<210>  2468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2468
caguugcuuc uccaaauuag                                                   20


<210>  2469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2469
gugcaaugca ccuaauuugg                                                   20


<210>  2470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2470
guuauccgug caaugcaccu                                                   20


<210>  2471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2471
cagguaauuu gacuuagacc                                                   20


<210>  2472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2472
auggucuaag ucaaauuacc                                                   20


<210>  2473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2473
gaacuauuuc agugucagcu                                                   20


<210>  2474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2474
gcugacacug aaauaguuca                                                   20


<210>  2475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2475
uaaaucagcu gacacugaaa                                                   20


<210>  2476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2476
ggcaaacucu uuucuuggua                                                   20


<210>  2477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2477
uuugaacugg guaagaauuc                                                   20


<210>  2478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2478
uaucauuuga acuggguaag                                                   20


<210>  2479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2479
gucuuggaau acagguuucu                                                   20


<210>  2480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2480
uuuuaugaau cuccuaaaag                                                   20


<210>  2481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2481
ccuaaaagac accauacuuu                                                   20


<210>  2482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2482
uagaaauaac caaauuuccu                                                   20


<210>  2483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2483
auauaauuau gguuaaguua                                                   20


<210>  2484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2484
cauuuaauuu uggaacauau                                                   20


<210>  2485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2485
uucacuaaaa uguaaccuga                                                   20


<210>  2486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2486
gauuaucccg uuuaccucuc                                                   20


<210>  2487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2487
gauauguuaa guuacauggg                                                   20


<210>  2488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2488
cguuuaccuc ucuuuggaug                                                   20


<210>  2489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2489
aaagagaggu aaacgggaua                                                   20


<210>  2490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2490
ccuaaagcau ccaaagagag                                                   20


<210>  2491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2491
cuguaacacc ccaaaguuag                                                   20


<210>  2492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2492
aauuucagcu ucaaaauagu                                                   20


<210>  2493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2493
aauauauuaa agguuuaaaa                                                   20


<210>  2494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2494
aguguuuuaa accuuuaaua                                                   20


<210>  2495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2495
caccucaugg ucaaacuggu                                                   20


<210>  2496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2496
cuuacaauuu gugugugugu                                                   20


<210>  2497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2497
aaaacacaca cacacacaca                                                   20


<210>  2498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2498
ugucacugua cuccagccug                                                   20


<210>  2499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2499
cggcuaccgc aaccucugcc                                                   20


<210>  2500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2500
cagcuacuag agaggcugag                                                   20


<210>  2501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2501
ccugaggucg ggaguucgag                                                   20


<210>  2502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2502
accugccuug gccccccaaa                                                   20


<210>  2503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2503
cagcacuuug gggggccaag                                                   20


<210>  2504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2504
aacuggcaaa aggccaggcg                                                   20


<210>  2505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2505
uuuuuuguuu cauugaacca                                                   20


<210>  2506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2506
uuuuccuuua ugauguggcu                                                   20


<210>  2507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2507
uaaaggaaaa ugaucuuuuu                                                   20


<210>  2508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2508
cugagggcca agccacauca                                                   20


<210>  2509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2509
uaucccugag ggccaagcca                                                   20


<210>  2510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2510
agaagccugg cacacagcaa                                                   20


<210>  2511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2511
gacugguaag aaauucuuac                                                   20


<210>  2512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2512
cugcuuaucu ccucuguaaa                                                   20


<210>  2513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2513
ccucuguaaa guuuugauua                                                   20


<210>  2514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2514
aaacuuuaca gaggagauaa                                                   20


<210>  2515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2515
uuuuuuccau uaaucaaaac                                                   20


<210>  2516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2516
caggcuguag ugaaucucgu                                                   20


<210>  2517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2517
cguaggcuuu augugucuuc                                                   20


<210>  2518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2518
cagaacagca cgggaagaca                                                   20


<210>  2519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2519
uaaggcgccc cuuuuuauca                                                   20


<210>  2520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2520
ugagcggcga gcaagcuuau                                                   20


<210>  2521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2521
gcagcaguua cugaccagcu                                                   20


<210>  2522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2522
cugaaacaaa caaaaaaacu                                                   20


<210>  2523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2523
aguuuuuuug uuuguuucag                                                   20


<210>  2524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2524
uguuuuaagu cuuugggagu                                                   20


<210>  2525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2525
aucuugagua guuacgaggc                                                   20


<210>  2526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2526
ugaguaguua cgaggcuuug                                                   20


<210>  2527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2527
ccacugaacu auagcacugg                                                   20


<210>  2528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2528
ggguuugauu ccuggcuuag                                                   20


<210>  2529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2529
aacccagauc accacugaac                                                   20


<210>  2530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2530
auuagaaagu acucauuccc                                                   20


<210>  2531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2531
aaaaauggca aagguuaccc                                                   20


<210>  2532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2532
ggccaaacag ccaauauucc                                                   20


<210>  2533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2533
acuuuuaauu aagcugacuu                                                   20


<210>  2534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2534
acuuccaauu ucugggguuu                                                   20


<210>  2535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2535
aucuacuucc aauuucuggg                                                   20


<210>  2536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2536
aaggcucugu ucuguuuugc                                                   20


<210>  2537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2537
aaugcaaaac agaacagagc                                                   20


<210>  2538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2538
acuguuuuuu acuugggggu                                                   20


<210>  2539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2539
gaaauuacuu cacauagaga                                                   20


<210>  2540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2540
cuaaaguaua uuuccugccu                                                   20


<210>  2541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2541
cccccaaaaa agagggaguc                                                   20


<210>  2542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2542
aggaucuggu auaaaaacga                                                   20


<210>  2543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2543
uggauccccc ccaaaaaaga                                                   20


<210>  2544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2544
gguauaaaaa cgagaccuca                                                   20


<210>  2545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2545
uagcacuuug agaggccgag                                                   20


<210>  2546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2546
acccaccucg gccucucaaa                                                   20


<210>  2547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2547
cuuuaaccca ggaggcggag                                                   20


<210>  2548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2548
caguucacug caaccuccgc                                                   20


<210>  2549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2549
ccaaaaauua agggucucuu                                                   20


<210>  2550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2550
guuuugccuu ccagcugugc                                                   20


<210>  2551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2551
uaaagccagu aauccaauuu                                                   20


<210>  2552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2552
aauuuagaaa cuuagaaagu                                                   20


<210>  2553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2553
uacaacuauu ggaucuucuu                                                   20


<210>  2554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2554
aauaguugua agauuuuuca                                                   20


<210>  2555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2555
ucuucugucu gucuguguag                                                   20


<210>  2556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2556
caacacuuug ggaggcugag                                                   20


<210>  2557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2557
acccaccuca gccucccaaa                                                   20


<210>  2558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2558
ccugagguca ggaguucgag                                                   20


<210>  2559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2559
cagcuacuca ggaggcugag                                                   20


<210>  2560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2560
cuugaacuca ggagguggag                                                   20


<210>  2561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2561
uggcucaggg caaccuccac                                                   20


<210>  2562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2562
agacuugggu gcaguggcac                                                   20


<210>  2563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2563
aauauuuuga aagaaaaaua                                                   20


<210>  2564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2564
uugggaaaua aaaaguuuua                                                   20


<210>  2565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2565
aaccugccua auuuaggcca                                                   20


<210>  2566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2566
caaaaaaaaa aaaaaaaaag                                                   20


<210>  2567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2567
cgccauugga cuccagccug                                                   20


<210>  2568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2568
aggcucacua caacgucugc                                                   20


<210>  2569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2569
aagcuacucg ggaggcugag                                                   20


<210>  2570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2570
cuacuaaaaa uacaaaaauu                                                   20


<210>  2571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2571
ugaggucagg aguucaagac                                                   20


<210>  2572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2572
ccccgccucc gccucccaaa                                                   20


<210>  2573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2573
cagcacuuug ggaggcggag                                                   20


<210>  2574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2574
aaugcuccaa aauaauuuga                                                   20


<210>  2575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2575
agaaucuaau gcuccaaaau                                                   20


<210>  2576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2576
ucuuugccua gcugggggca                                                   20


<210>  2577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2577
uuucuuauau aaaauuuauu                                                   20


<210>  2578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2578
cguaugguaa auucuugccc                                                   20


<210>  2579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2579
auggcauggu uggacuuucu                                                   20


<210>  2580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2580
uuuaacaacu uacacaggcc                                                   20


<210>  2581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2581
uuuacuuuug gugcaugaau                                                   20


<210>  2582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2582
uuuaccaaaa acacauuuca                                                   20


<210>  2583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2583
aacuuaaaaa cccuuuaacc                                                   20


<210>  2584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2584
uaucuaacuu aaaaacccuu                                                   20


<210>  2585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2585
uguaaaagaa auucugugug                                                   20


<210>  2586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2586
caaaaaaaaa aaauagaaag                                                   20


<210>  2587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2587
cuuaaaccca gggggcagag                                                   20


<210>  2588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2588
cagcuacucc agaggcugag                                                   20


<210>  2589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2589
cgaggucagg aguucaagac                                                   20


<210>  2590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2590
gcccgccucc accucccaaa                                                   20


<210>  2591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2591
uagcacuuug ggagguggag                                                   20


<210>  2592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2592
caucacuuug ggaggcugag                                                   20


<210>  2593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2593
cuuugggagg cugaggcagg                                                   20


<210>  2594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2594
accugccuca gccucccaaa                                                   20


<210>  2595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2595
cgaggucagg agaucgagac                                                   20


<210>  2596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2596
ccugaccucg ugaucuaccu                                                   20


<210>  2597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2597
agaccauccg ggcguggugg                                                   20


<210>  2598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2598
gggcguggug gcgggcgccu                                                   20


<210>  2599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2599
cagcucacug caagcucugc                                                   20


<210>  2600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2600
uuaacccauu uuuaacccag                                                   20


<210>  2601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2601
caugcuuuac uuagguaaaa                                                   20


<210>  2602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2602
ccuuuggauu gcgauaguaa                                                   20


<210>  2603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2603
aaaggagaua ggcugcagca                                                   20


<210>  2604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2604
caauccaaag gagauaggcu                                                   20


<210>  2605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2605
gcuaaccuuu uagcuuaguu                                                   20


<210>  2606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2606
aaucugcuaa ccuuuuagcu                                                   20


<210>  2607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2607
uuaguaagau uucaccauuu                                                   20


<210>  2608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2608
uacuaaagau gacuacagug                                                   20


<210>  2609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2609
agggaagcug agcguaaagc                                                   20


<210>  2610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2610
uuggcuaaau uaaucaaggg                                                   20


<210>  2611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2611
ccacgaauuu ucaaaagcca                                                   20


<210>  2612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2612
gacugggucu gaaagaaacu                                                   20


<210>  2613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2613
aguuagaggc cucuuacauc                                                   20


<210>  2614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2614
aggccgguua auuaccguau                                                   20


<210>  2615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2615
aaucuauucc uggacccauc                                                   20


<210>  2616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2616
auuccuggac ccauccauuu                                                   20


<210>  2617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2617
auuuucuuug gcgacuucca                                                   20


<210>  2618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2618
aaacuggguu uggaagucgc                                                   20


<210>  2619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2619
gaaauuugca caaagaaaac                                                   20


<210>  2620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2620
acaguuugug uuucgagcuc                                                   20


<210>  2621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2621
ccaaaaucca agagaggacu                                                   20


<210>  2622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2622
aagagaggac uuauccauga                                                   20


<210>  2623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2623
augaucccca gcugcucuga                                                   20


<210>  2624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2624
uggauaaguc cucucuugga                                                   20


<210>  2625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2625
ccagcugcuc ugagaaauca                                                   20


<210>  2626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2626
auggacacaa guguguccag                                                   20


<210>  2627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2627
aaaguaaagc uucuaaugac                                                   20


<210>  2628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2628
cacuucugac accauguuaa                                                   20


<210>  2629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2629
uucauugcuu aauuaaacuc                                                   20


<210>  2630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2630
cagcagauuc agagagacuc                                                   20


<210>  2631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2631
gcugggauuc ugaggacugc                                                   20


<210>  2632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2632
cuggagucuc ucugaaucug                                                   20


<210>  2633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2633
cagcagccau auuucacuca                                                   20


<210>  2634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2634
ugucuaccua uaaguuaggu                                                   20


<210>  2635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2635
acaaagacuc aaauacagaa                                                   20


<210>  2636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2636
gguuuuucuu uuggcaaaca                                                   20


<210>  2637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2637
uaaugauuuu uaagcauagg                                                   20


<210>  2638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2638
uuaagauggu aaauuuuaug                                                   20


<210>  2639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2639
aucauucauu caaucaguuu                                                   20


<210>  2640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2640
uucauucaau caguuugcac                                                   20


<210>  2641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2641
guuugcacag uuaacucuuu                                                   20


<210>  2642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2642
uguaaagcug aagcucuguc                                                   20


<210>  2643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2643
ccugucucag uggaaucaga                                                   20


<210>  2644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2644
gacagcauuu gccccuugug                                                   20


<210>  2645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2645
cggcucacug caaccucugc                                                   20


<210>  2646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2646
uuaguagaga cgggguuuca                                                   20


<210>  2647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2647
uggccaacac ggugaaaccc                                                   20


<210>  2648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2648
ccugaccucg ugaucugccc                                                   20


<210>  2649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2649
cgaggucagg agaugaagac                                                   20


<210>  2650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2650
gcccgccucg gccucccaaa                                                   20


<210>  2651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2651
cagcacuuug ggaggccgag                                                   20


<210>  2652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2652
auguuguagu gugugucaga                                                   20


<210>  2653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2653
aagaacccuc ucuugggguc                                                   20


<210>  2654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2654
ugcucaagaa agaauucaga                                                   20


<210>  2655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2655
gggcugcucu gcccauggag                                                   20


<210>  2656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2656
ccacugcacu ccagccuggg                                                   20


<210>  2657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2657
cggcucacug caagcuccgc                                                   20


<210>  2658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2658
uggcuaacau ggugaaaccc                                                   20


<210>  2659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2659
ccugaccuug ugauccgccc                                                   20


<210>  2660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2660
caaggucagg agauugagac                                                   20


<210>  2661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2661
gcccgccuca gccucccaaa                                                   20


<210>  2662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2662
cagcacuuug ggaggcugag                                                   20


<210>  2663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2663
gcagggcgug guggcucacg                                                   20


<210>  2664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2664
agaaauaauc agcagggcgu                                                   20


<210>  2665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2665
accucuuguu uagcauauaa                                                   20


<210>  2666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2666
cagcacuuug ggaggccaag                                                   20


<210>  2667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2667
gcccgccuug gccucccaaa                                                   20


<210>  2668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2668
cuacuaaaaa uaaaaaauua                                                   20


<210>  2669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2669
cuugaacccg ggaagccgag                                                   20


<210>  2670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2670
cggcucacca caaccucggc                                                   20


<210>  2671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2671
guaaacuguc auggggcugg                                                   20


<210>  2672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2672
cugguuguuc ucacagcuca                                                   20


<210>  2673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2673
cuuucauugc caucuugguu                                                   20


<210>  2674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2674
ugguuuuggu gggcuuuggc                                                   20


<210>  2675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2675
guaaggucuu ugugaccugu                                                   20


<210>  2676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2676
ugugucagcc uccuaccuca                                                   20


<210>  2677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2677
ugugacuaug aaugccuaac                                                   20


<210>  2678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2678
ugaauagggg cgggguaaaa                                                   20


<210>  2679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2679
uuuuacauuu cuuuuuuuuu                                                   20


<210>  2680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2680
uaccacagca cuccagccug                                                   20


<210>  2681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2681
cggcucacug caaucuccac                                                   20


<210>  2682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2682
ccaccuccga gguuccagcg                                                   20


<210>  2683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2683
cuggaaccuc ggagguggag                                                   20


<210>  2684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2684
uacugggcua auuuuugugu                                                   20


<210>  2685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2685
cuacuaaaaa cacaaaaauu                                                   20


<210>  2686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2686
gccugggcaa cauggggaaa                                                   20


<210>  2687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2687
caaacuccug ggcuuaagca                                                   20


<210>  2688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2688
caacacuuug ggaggccaac                                                   20


<210>  2689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2689
uugcguccuu gcagaugaau                                                   20


<210>  2690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2690
gcaaggacgc aaggauggca                                                   20


<210>  2691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2691
uaaccuagca uaguagguag                                                   20


<210>  2692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2692
ggcuguuaac gugccucacu                                                   20


<210>  2693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2693
cuagagucuc ccugaaucug                                                   20


<210>  2694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2694
gcugugauuc ugggaccugc                                                   20


<210>  2695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2695
cagcagauuc agggagacuc                                                   20


<210>  2696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2696
aggaaaaaaa aaacaauuca                                                   20


<210>  2697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2697
gcuaaacucu guucaauuca                                                   20


<210>  2698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2698
ggccacugca cuccagccug                                                   20


<210>  2699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2699
cggcccacug caaccuccac                                                   20


<210>  2700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2700
cagcuacuca ggaggcugag                                                   20


<210>  2701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2701
cuacuaaaaa uacaaaaauu                                                   20


<210>  2702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2702
cagcauuuug ggaggccaag                                                   20


<210>  2703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2703
ucuugauauu aauguugcuu                                                   20


<210>  2704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2704
agaagaugag gccaggcgca                                                   20


<210>  2705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2705
uugucccugu guuuuuuguu                                                   20


<210>  2706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2706
cgccacugaa cuccagccug                                                   20


<210>  2707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2707
cagcucacug caaccucugu                                                   20


<210>  2708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2708
cuggaaccca ggagacagag                                                   20


<210>  2709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2709
aaagacccag gaacacagcu                                                   20


<210>  2710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2710
cacuuagcau guacgcacag                                                   20


<210>  2711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2711
uuugaaagac auugccaagu                                                   20


<210>  2712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2712
cuuuucugaa gagugacuug                                                   20


<210>  2713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2713
cgguuggugu cucuucaauc                                                   20


<210>  2714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2714
uuccucacac uuuucuuggg                                                   20


<210>  2715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2715
ugagucuacu acauuuacac                                                   20


<210>  2716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2716
uuagaaacag gaucucauuu                                                   20


<210>  2717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2717
uguuucuaaa gaugcuuuaa                                                   20


<210>  2718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2718
cauuuuguug cccaggcuag                                                   20


<210>  2719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2719
ugccaccaaa cucuagccug                                                   20


<210>  2720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2720
cuugagccca ggaguaugag                                                   20


<210>  2721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2721
uuccaccucu gaaaccccaa                                                   20


<210>  2722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2722
caggugugca cccucaaccu                                                   20


<210>  2723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2723
ucacaggugu gcacccucaa                                                   20


<210>  2724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2724
gccuaaauaa uuucuuuuua                                                   20


<210>  2725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2725
agcugcagac auacacaagc                                                   20


<210>  2726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2726
gccuggcccc agguagccuu                                                   20


<210>  2727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2727
aacauggcgg cuccaucuuc                                                   20


<210>  2728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2728
ucccuuuccu ugucaaccau                                                   20


<210>  2729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2729
uugggcccug uguaaauuag                                                   20


<210>  2730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2730
auguucuuga uuuccuuggc                                                   20


<210>  2731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2731
agaacauaga uacacacgga                                                   20


<210>  2732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2732
ugaugacaug uucccaagau                                                   20


<210>  2733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2733
ggauuuccug aggcuguguc                                                   20


<210>  2734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2734
ugggaacaug ucaucaggau                                                   20


<210>  2735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2735
ccgauaagcc uuuccaaagg                                                   20


<210>  2736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2736
gagauucaaa agaaugcaac                                                   20


<210>  2737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2737
gaauaugcgu cuauugacug                                                   20


<210>  2738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2738
acccaccucc gccucccaaa                                                   20


<210>  2739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2739
ccugagguca ggaguuugag                                                   20


<210>  2740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2740
cagcuacucg ggaggcugag                                                   20


<210>  2741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2741
cagcucacug caaccucuuc                                                   20


<210>  2742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2742
cagaaaaaaa aaaaaaaggc                                                   20


<210>  2743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2743
cagcacuuug ggaagccgag                                                   20


<210>  2744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2744
ccugacuuug ugaccugccc                                                   20


<210>  2745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2745
uggcuaacau gaugaaaccc                                                   20


<210>  2746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2746
uguuagccag gauggucuca                                                   20


<210>  2747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2747
cuacuaaaaa auacaaaaaa                                                   20


<210>  2748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2748
cggcucacug caagcuccgc                                                   20


<210>  2749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2749
caccacugca cuccagcccg                                                   20


<210>  2750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2750
caaauuaaaa aaaaaaaaaa                                                   20


<210>  2751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2751
aucucaguga gcagaaggau                                                   20


<210>  2752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2752
cagugagcag aaggaugacu                                                   20


<210>  2753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2753
uucugcucac ugagauagau                                                   20


<210>  2754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2754
cugaagcuaa aggggaaguu                                                   20


<210>  2755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2755
cagcauuucg ggaggcugag                                                   20


<210>  2756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2756
ccugcacccu cccuuccccu                                                   20


<210>  2757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2757
aaguccgggc ucacaccaga                                                   20


<210>  2758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2758
caugcugugc cuagaaucga                                                   20


<210>  2759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2759
gcgcacagga gaagugaagu                                                   20


<210>  2760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2760
ccacugugca cugcugaggg                                                   20


<210>  2761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2761
uuagaacaga cucuugcggu                                                   20


<210>  2762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2762
uccaagugag aagugaaagg                                                   20


<210>  2763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2763
uguguugugu gguauguggg                                                   20


<210>  2764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2764
ucuaguaagg aaacaagugg                                                   20


<210>  2765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2765
cuuuaguaaa agguccgguu                                                   20


<210>  2766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2766
uccugauccu ccuccccagg                                                   20


<210>  2767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2767
ggaagaucuc uuuaguaaaa                                                   20


<210>  2768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2768
uccuccccag gccaggggag                                                   20


<210>  2769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2769
uguaacuaga cuaugaaugu                                                   20


<210>  2770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2770
cuguaagggu caguugaagu                                                   20


<210>  2771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2771
cuccccauga aagaaauaua                                                   20


<210>  2772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2772
auaucccucc ccaugaaaga                                                   20


<210>  2773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2773
gggaucagca gagguguuuc                                                   20


<210>  2774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2774
cugauccaua ucccucccca                                                   20


<210>  2775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2775
gcagaggugu uucagucccg                                                   20


<210>  2776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2776
ugagccacug ucuugcugcu                                                   20


<210>  2777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2777
uaagacuagu ggaguacacc                                                   20


<210>  2778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2778
cugucguccu acaagaacca                                                   20


<210>  2779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2779
gucaguggca gagccagccu                                                   20


<210>  2780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2780
agaugagaca gagcuggugg                                                   20


<210>  2781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2781
agauggggcc uucuguccag                                                   20


<210>  2782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2782
gccaggccgu uugagcugcc                                                   20


<210>  2783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2783
cucccaggug acucucuucc                                                   20


<210>  2784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2784
ucccaccuca gccuccccaa                                                   20


<210>  2785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2785
cagcgcuugg ggaggcugag                                                   20


<210>  2786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2786
uuuauuggcc agcauggggg                                                   20


<210>  2787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2787
ucuuuuauug gccagcaugg                                                   20


<210>  2788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2788
ccuccauaaa aucaucuuuu                                                   20


<210>  2789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2789
ugagaacuuc cugggugagc                                                   20


<210>  2790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2790
uuuguucuaa ugaggugacu                                                   20


<210>  2791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2791
aggagccacc aagagucacc                                                   20


<210>  2792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2792
ccagaaagau caagccagag                                                   20


<210>  2793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2793
uucuggugau ucacuccuau                                                   20


<210>  2794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2794
agccagaguu agaagcagaa                                                   20


<210>  2795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2795
caaaaaaaaa aaaaaaaacu                                                   20


<210>  2796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2796
cagcucacua caagcucugc                                                   20


<210>  2797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2797
cuugaaccug ggaggcagag                                                   20


<210>  2798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2798
ggcuaauuuu uguauuuuua                                                   20


<210>  2799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2799
caagguaagg aguuugaggc                                                   20


<210>  2800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2800
gccugccuca gccucccaaa                                                   20


<210>  2801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2801
cagcacuuug ggaggcugag                                                   20


<210>  2802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2802
acuaacuaac caaauaaaua                                                   20


<210>  2803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2803
aaccuaauua agaaacuaaa                                                   20


<210>  2804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2804
uguaaagaga gaaagauaau                                                   20


<210>  2805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2805
uucucucuuu acaugauuuu                                                   20


<210>  2806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2806
aaguuuuaug uuuauguuca                                                   20


<210>  2807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2807
aaacuaacca caaguaaaau                                                   20


<210>  2808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2808
uauuuaggcu ucuauuuuac                                                   20


<210>  2809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2809
gacaugggaa uguuagcaca                                                   20


<210>  2810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2810
auuuauacuu gcuuuauaaa                                                   20


<210>  2811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2811
uauaaagacc uuauacaaaa                                                   20


<210>  2812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2812
cuuuuaugaa uacaaaaccc                                                   20


<210>  2813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2813
uaacauagug ggguuuauuu                                                   20


<210>  2814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2814
augcauuauu gaaauaaacc                                                   20


<210>  2815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2815
auuauauugu guuacugaau                                                   20


<210>  2816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2816
ugugaauaua cccaaagaaa                                                   20


<210>  2817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2817
auuuuuucuu uggguauauu                                                   20


<210>  2818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2818
augaaaauaa ucuauuuuuu                                                   20


<210>  2819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2819
ugcuaaagaa ggaguaacua                                                   20


<210>  2820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2820
gcccagaagg caucauuuua                                                   20


<210>  2821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2821
uuuuacccga uaagggcaca                                                   20


<210>  2822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2822
gguaaaauga ugccuucugg                                                   20


<210>  2823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2823
ucuuauuccu aauuuuaaca                                                   20


<210>  2824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2824
cuugaaccug ggaggcgggg                                                   20


<210>  2825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2825
cuacuaaaau acaaaaaaaa                                                   20


<210>  2826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2826
caguacguga gguugggagu                                                   20


<210>  2827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2827
uuaauacuga ugcuuauuga                                                   20


<210>  2828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2828
guauuaagga uaauguugaa                                                   20


<210>  2829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2829
agagguaacc ccauaguaag                                                   20


<210>  2830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2830
auaauaaguu gaaaauauaa                                                   20


<210>  2831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2831
uagcugagcc cagccugccu                                                   20


<210>  2832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2832
cacagcagca cagucuacug                                                   20


<210>  2833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2833
gcuguuugcc cuugugacug                                                   20


<210>  2834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2834
cuagccuggg gaaagaucaa                                                   20


<210>  2835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2835
uuccccaggc uagugaugug                                                   20


<210>  2836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2836
aaguugaaaa uuugaagugu                                                   20


<210>  2837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2837
ucaagucaaa aaauuuuagu                                                   20


<210>  2838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2838
agucaaaaaa uuuuaguuga                                                   20


<210>  2839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2839
uuauuuucag gaggaacuuc                                                   20


<210>  2840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2840
auguacaugg aaguuccucc                                                   20


<210>  2841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2841
uccgucauca auguacaugg                                                   20


<210>  2842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2842
guuucuauca uccuaaugaa                                                   20


<210>  2843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2843
uccuaaugaa cauaaugaau                                                   20


<210>  2844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2844
uaaugaacau aaugaauaaa                                                   20


<210>  2845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2845
agacaaacau aaacauuaac                                                   20


<210>  2846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2846
gcaaauaccc gcaaagcaga                                                   20


<210>  2847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2847
ggacaaggua ucuggaaggc                                                   20


<210>  2848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2848
ggaaggcuga gcuaagccuc                                                   20


<210>  2849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2849
caccauugca cuccagccug                                                   20


<210>  2850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2850
cagcucacug caaccuccac                                                   20


<210>  2851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2851
cuugaaccag ggagguggag                                                   20


<210>  2852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2852
cagcuacucg ggaggcugag                                                   20


<210>  2853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2853
gcugggugua guggcgggag                                                   20


<210>  2854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2854
uggccaacau ggugaaaccc                                                   20


<210>  2855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2855
agaccauccu ggccaacaug                                                   20


<210>  2856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2856
cuugacguca ugaucugucc                                                   20


<210>  2857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2857
ugacgucaag agaucgagac                                                   20


<210>  2858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2858
guccaccucg gccucccaaa                                                   20


<210>  2859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2859
cagcacuuug ggaggccgag                                                   20


<210>  2860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2860
agcgcaugcc aaguuuaggg                                                   20


<210>  2861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2861
uucuucuugg guggggugga                                                   20


<210>  2862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2862
auauuucaga gcugguuuac                                                   20


<210>  2863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2863
cuucauauca accacaucca                                                   20


<210>  2864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2864
accacaucca guuccucaaa                                                   20


<210>  2865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2865
aguuccucaa aacuggaacu                                                   20


<210>  2866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2866
aaguuccagu uuugaggaac                                                   20


<210>  2867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2867
uaauccaagu uccaguuuug                                                   20


<210>  2868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2868
ucuccggaag aagauaauac                                                   20


<210>  2869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2869
ucuuccggag aggauuuuug                                                   20


<210>  2870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2870
cguuccuggu aauuuguguu                                                   20


<210>  2871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2871
ggccucauau cacguuccug                                                   20


<210>  2872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2872
aucaggccuc auaucacguu                                                   20


<210>  2873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2873
aucuaguguc uagauaaugg                                                   20


<210>  2874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2874
agugucuaga uaauggagau                                                   20


<210>  2875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2875
agacacuaga uagauucuag                                                   20


<210>  2876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2876
ccauuaucua gacacuagau                                                   20


<210>  2877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2877
gaaacuauaa aaugugacaa                                                   20


<210>  2878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2878
gacuuacuuc cuaguucucu                                                   20


<210>  2879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2879
uuucuucugc auuuuccauu                                                   20


<210>  2880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2880
ucucaccaua uccuuucuuc                                                   20


<210>  2881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2881
aauauacauu uauuuggagu                                                   20


<210>  2882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2882
guuucgaagc cucucaguca                                                   20


<210>  2883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2883
guucacaaau ucaaagccca                                                   20


<210>  2884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2884
auacugugaa agcaagucca                                                   20


<210>  2885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2885
acaauacaca ggacaggcau                                                   20


<210>  2886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2886
uaugccuguc cuguguauug                                                   20


<210>  2887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2887
gaaggaggca cuucucuccc                                                   20


<210>  2888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2888
ucccagggcc agggacagcu                                                   20


<210>  2889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2889
cagggccagg gacagcuggu                                                   20


<210>  2890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2890
cucuccuagu gaacucccua                                                   20


<210>  2891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2891
ggcuucuugu cauucugggu                                                   20


<210>  2892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2892
cauagcaaug ggagauuuca                                                   20


<210>  2893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2893
cccauugcua ugcgauuggc                                                   20


<210>  2894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2894
ugaccuuaga aaucuuucac                                                   20


<210>  2895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2895
uucaccgagg gggaucugcg                                                   20


<210>  2896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2896
cccucgguga aagauuucua                                                   20


<210>  2897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2897
gcguuccaga acuucuggag                                                   20


<210>  2898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2898
ggccaacaag cagacuuguc                                                   20


<210>  2899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2899
cugcaaaacu acagaaaacc                                                   20


<210>  2900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2900
uaaaagcagc cagauuuaaa                                                   20


<210>  2901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2901
ggcugcuuuu aagauuuucu                                                   20


<210>  2902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2902
gcugucaauu ucauggcugc                                                   20


<210>  2903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2903
cagcacuuug ggaggccgag                                                   20


<210>  2904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2904
acccgccucg gccucccaaa                                                   20


<210>  2905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2905
cgaggucagg agaccaagac                                                   20


<210>  2906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2906
uggcuaacau ggugaaaccc                                                   20


<210>  2907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2907
cggcucacug caagcuccgc                                                   20


<210>  2908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2908
ccugaaagga agcaacugcc                                                   20


<210>  2909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2909
aaggcggcag uugcuuccuu                                                   20


<210>  2910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2910
aaucaaaggc ggcaguugcu                                                   20


<210>  2911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2911
gugaagaagg aaggcaaaau                                                   20


<210>  2912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2912
ggaaguguuu uuauuuugcc                                                   20


<210>  2913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2913
uuccaguuca aucaggaagu                                                   20


<210>  2914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2914
uuuagaauuc cuuggacagu                                                   20


<210>  2915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2915
uccucugggg ucauuuucuu                                                   20


<210>  2916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2916
gagauucagg aaagaaaugg                                                   20


<210>  2917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2917
cugaucuucc ucugggguca                                                   20


<210>  2918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2918
cucuccauuu cuuuccugaa                                                   20


<210>  2919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2919
uuuguaacau auaugugugu                                                   20


<210>  2920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2920
ugacaaaaaa aaaaaaaaaa                                                   20


<210>  2921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2921
aucuugacaa aaaaaaaaaa                                                   20


<210>  2922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2922
uuugagccca aggggcagag                                                   20


<210>  2923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2923
cagcuacuca ggaggcugag                                                   20


<210>  2924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2924
cuaguaaaaa uacaaaaauu                                                   20


<210>  2925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2925
caucucuagu aaaaauacaa                                                   20


<210>  2926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2926
ccugagguca gguguucaag                                                   20


<210>  2927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2927
accugccugg gccucccaaa                                                   20


<210>  2928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2928
uagcacuuug ggaggcccag                                                   20


<210>  2929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2929
ggccuaugug uguguuuaua                                                   20


<210>  2930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2930
agaagagaau agauuuacgu                                                   20


<210>  2931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2931
auucucuucu ugauuaugca                                                   20


<210>  2932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2932
aacguaaauc uauucucuuc                                                   20


<210>  2933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2933
aaaucuaacg uaaaucuauu                                                   20


<210>  2934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2934
uccagguauc aaaaucuaac                                                   20


<210>  2935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2935
caaaaaaaaa aaaacauaca                                                   20


<210>  2936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2936
caccacaaca cuccagccug                                                   20


<210>  2937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2937
uggcucacug caaccuccuc                                                   20


<210>  2938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2938
ucccaccuag gccuccagag                                                   20


<210>  2939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2939
caccuacucu ggaggccuag                                                   20


<210>  2940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2940
caggcaccug ccaccacacc                                                   20


<210>  2941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2941
cuacuaaaua uuuaaaaaaa                                                   20


<210>  2942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2942
ccugagguca ggaguucaag                                                   20


<210>  2943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2943
gccuaccucu gccucucaaa                                                   20


<210>  2944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2944
cagcacuuug agaggcagag                                                   20


<210>  2945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2945
cgcccggcca acagugauca                                                   20


<210>  2946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2946
cuguuggccg ggcgcgaugg                                                   20


<210>  2947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2947
cuuucaaacu aacagagguu                                                   20


<210>  2948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2948
gacuuaacca aaaaccaggu                                                   20


<210>  2949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2949
uaccagcucu guuaccuggu                                                   20


<210>  2950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2950
acgauuacag uuaauauuaa                                                   20


<210>  2951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2951
uugauauacg ugaggucagu                                                   20


<210>  2952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2952
guccuguuuc cuuagguucu                                                   20


<210>  2953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2953
uaugagacgg gaaagguuuc                                                   20


<210>  2954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2954
caccuggucu cgggucgggg                                                   20


<210>  2955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2955
cacugggcgg ggagcuaagc                                                   20


<210>  2956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2956
uccccugaau aguucauguu                                                   20


<210>  2957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2957
uugugcuuuu ccauauuuuu                                                   20


<210>  2958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2958
uaaucuuugu gcuuuuccau                                                   20


<210>  2959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2959
agccacugca cuccagccug                                                   20


<210>  2960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2960
cagcucacug caaccuccgc                                                   20


<210>  2961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2961
cuugaaccca ggaggcggag                                                   20


<210>  2962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2962
cagcuacuca agaggcugag                                                   20


<210>  2963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2963
uguuggucag gcggacuuga                                                   20


<210>  2964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2964
ccugagguca ggaguucaag                                                   20


<210>  2965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2965
gcccaccucg gccucccaaa                                                   20


<210>  2966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2966
cagcacuuug ggaggccgag                                                   20


<210>  2967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2967
cucuucugug uauguguacg                                                   20


<210>  2968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2968
ggcucuacau gguguguagu                                                   20


<210>  2969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2969
ggaacaggau ucuaaugacu                                                   20


<210>  2970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2970
uguuccagau gagcacuugu                                                   20


<210>  2971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2971
caacauagcc acaggcaguc                                                   20


<210>  2972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2972
aucuuuuuuc caucuuuugu                                                   20


<210>  2973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2973
uuuuuccauc uuuuguccua                                                   20


<210>  2974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2974
uuuguccuaa guguugcuau                                                   20


<210>  2975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2975
uugaucacac augccugacu                                                   20


<210>  2976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2976
augauuuauu auagcaacac                                                   20


<210>  2977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2977
cacaugccug acuguuugca                                                   20


<210>  2978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2978
uaugcaaaca gucaggcaug                                                   20


<210>  2979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2979
auacugggca gucuggcaug                                                   20


<210>  2980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2980
uuacucuuuu uagaugaugc                                                   20


<210>  2981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2981
aaaaagagua aagaucaaua                                                   20


<210>  2982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2982
ucuaaaaaga guaaagauca                                                   20


<210>  2983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2983
aaugugaaag acuuacagaa                                                   20


<210>  2984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2984
ugacaggaaa ucuaauguga                                                   20


<210>  2985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2985
uccugacagg aaaucuaaug                                                   20


<210>  2986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2986
gccuagaauu gacuaucauc                                                   20


<210>  2987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2987
ucugccuaga auugacuauc                                                   20


<210>  2988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2988
caacugcuuc agccauggcu                                                   20


<210>  2989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2989
ggacuuuaca uggccacaac                                                   20


<210>  2990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2990
ucgggacuuu acauggccac                                                   20


<210>  2991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2991
auugccuccc uggauggguu                                                   20


<210>  2992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2992
agggaggcaa uggaucaucg                                                   20


<210>  2993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2993
guaagggaga aauacacuuc                                                   20


<210>  2994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2994
gggcccccuc cuuccagcuc                                                   20


<210>  2995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2995
ccccaggaug uggcuuuuau                                                   20


<210>  2996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2996
uggggugaug ggagcuggaa                                                   20


<210>  2997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2997
gcauaaaagc cacauccugg                                                   20


<210>  2998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2998
ucugcauaaa agccacaucc                                                   20


<210>  2999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  2999
aaaauggcug cucaaguccc                                                   20


<210>  3000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3000
cauuccaggg agcaggaaaa                                                   20


<210>  3001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3001
cauaaaauga agggaaagac                                                   20


<210>  3002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3002
cccuggcuag cacuuacuua                                                   20


<210>  3003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3003
aagcaguuug ccucuuagcu                                                   20


<210>  3004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3004
accugaauga gggacacagu                                                   20


<210>  3005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3005
cauucugagg uucuggggcu                                                   20


<210>  3006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3006
cauuuuagcc uccuuaccuc                                                   20


<210>  3007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3007
uuaggguggg ccauaauccg                                                   20


<210>  3008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3008
gacugauguc uuacaagaag                                                   20


<210>  3009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3009
gucggauuau ggcccacccu                                                   20


<210>  3010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3010
cuucuuguaa gacaucaguc                                                   20


<210>  3011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3011
cggacuucua gccucuagga                                                   20


<210>  3012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3012
ucucaugguc cuagaggcua                                                   20


<210>  3013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3013
gcugcuggaa caaaucaccc                                                   20


<210>  3014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3014
ccccagcacu guggcuuggc                                                   20


<210>  3015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3015
ucacacguuc ugugggucag                                                   20


<210>  3016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3016
cacguggugu uggcaggauc                                                   20


<210>  3017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3017
ugccaacacc acgugagauu                                                   20


<210>  3018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3018
aguuccucau ggccugcugg                                                   20


<210>  3019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3019
gagcauccau gccaagaagg                                                   20


<210>  3020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3020
augccaagaa ggcaacagag                                                   20


<210>  3021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3021
ccuuugccca uugguuagaa                                                   20


<210>  3022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3022
uaugagucug cccacugagg                                                   20


<210>  3023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3023
ugccauugca cuccagccug                                                   20


<210>  3024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3024
uggcucacug caaccuccac                                                   20


<210>  3025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3025
ccagagguca ggaguucgag                                                   20


<210>  3026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3026
gccugccuug gccucccaaa                                                   20


<210>  3027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3027
cagcacuuug ggaggccaag                                                   20


<210>  3028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3028
cccaagcugg agugcagugg                                                   20


<210>  3029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3029
uagcucacuu gcagccucaa                                                   20


<210>  3030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3030
ccugaaccca ggaauuugag                                                   20


<210>  3031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3031
ucccacauca gccucccaag                                                   20


<210>  3032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3032
gccucccaag aacugggaac                                                   20


<210>  3033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3033
ccccccggcu gggcgguugu                                                   20


<210>  3034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3034
uguggccaua gcugcuucuc                                                   20


<210>  3035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3035
cagugccucu gugggcagca                                                   20


<210>  3036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3036
gucccagcgc agcgccccgg                                                   20


<210>  3037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3037
cccgccgacg ccuggagcgg                                                   20


<210>  3038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3038
uuuccgcaug ggccugcgcc                                                   20


<210>  3039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3039
cgcuccgccc cucagccgcc                                                   20


<210>  3040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3040
ccccgccccg cccccgucuc                                                   20


<210>  3041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3041
ccacgccccc cgcaucgcca                                                   20


<210>  3042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3042
ccacgccucc cuuaccaugc                                                   20


<210>  3043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3043
ugcuggccgg cguggccccg                                                   20


<210>  3044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3044
uggacccguc ccggcagccc                                                   20


<210>  3045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3045
gcuuuuccag ggucgccaug                                                   20


<210>  3046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3046
ccgccguagc cugggacccg                                                   20


<210>  3047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3047
ugcgaagggc gagagggcug                                                   20


<210>  3048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3048
cggcuccucc aaguucucuu                                                   20


<210>  3049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3049
cuccagcucc aaaccccgcc                                                   20


<210>  3050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3050
acugccccca caucucucca                                                   20


<210>  3051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3051
cccauuggac gcgcccucac                                                   20


<210>  3052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3052
caggcuguuu uaagugccac                                                   20


<210>  3053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3053
ugaacuaaau gaaauguccu                                                   20


<210>  3054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3054
cggugguagu aacacgauuu                                                   20


<210>  3055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3055
uguuacuacc accgugauca                                                   20


<210>  3056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3056
cuuagguggu gcuuaaaauc                                                   20


<210>  3057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3057
gcucaucuaa gccuaaguug                                                   20


<210>  3058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3058
aagccuaagu uggucugcag                                                   20


<210>  3059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3059
ccacguaagu ucaccacuuu                                                   20


<210>  3060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3060
uaaauauuag gaagaguuga                                                   20


<210>  3061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3061
acucuuccua auauuuaaga                                                   20


<210>  3062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3062
gcaacguguu gguuuuauuc                                                   20


<210>  3063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3063
cucggcaauu aaccucccca                                                   20


<210>  3064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3064
cagaugugcc agugaaaggg                                                   20


<210>  3065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3065
gagaugccca cggagucugc                                                   20


<210>  3066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3066
agcggaaccc caggacuuuc                                                   20


<210>  3067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3067
gaaauagaau acugagaggu                                                   20


<210>  3068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3068
ggaugugucc cagauggcau                                                   20


<210>  3069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3069
agaucggaaa uagaauacug                                                   20


<210>  3070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3070
gggacacauc cagaucggaa                                                   20


<210>  3071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3071
cuguuaagac ugauuaauuu                                                   20


<210>  3072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3072
gucuuaacag agauauucuu                                                   20


<210>  3073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3073
uaacagaaac aaagaacaag                                                   20


<210>  3074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3074
uugucucguc uucaaaguuu                                                   20


<210>  3075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3075
uuuucuaauu aaacuuugaa                                                   20


<210>  3076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3076
uuuagaauaa uuuauuccua                                                   20


<210>  3077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3077
aaaaaguuuu uccauccuuu                                                   20


<210>  3078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3078
cuucaguaag uaauuucuca                                                   20


<210>  3079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3079
agaaauuuac uguagugcuu                                                   20


<210>  3080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3080
uguguaaaca cuaaacaggg                                                   20


<210>  3081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3081
ggagcccugu uuaguguuua                                                   20


<210>  3082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3082
agugucugaa gcagcccagc                                                   20


<210>  3083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3083
uucuaaaaau augccuucuc                                                   20


<210>  3084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3084
gcauaagaaa gagaaggcau                                                   20


<210>  3085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3085
ucaaaauaug gguaucaaga                                                   20


<210>  3086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3086
agaaauuucc uuugcugccu                                                   20


<210>  3087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3087
ccuuugucaa ggcagcaaag                                                   20


<210>  3088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3088
aucuccuuug ucaaggcagc                                                   20


<210>  3089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3089
uauauuaccu uaaaguaaug                                                   20


<210>  3090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3090
ggacuggcaa gguggcuuac                                                   20


<210>  3091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3091
gagcacuuug ggaggccuag                                                   20


<210>  3092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3092
ccugagguca ggaguuugag                                                   20


<210>  3093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3093
aagcuaccug ggaggcugag                                                   20


<210>  3094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3094
cuugaacccg ggaggcagag                                                   20


<210>  3095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3095
caacucacug cagacucugc                                                   20


<210>  3096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3096
cgccacugca cuccagccug                                                   20


<210>  3097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3097
caaaaaaaau uuuuuuuaau                                                   20


<210>  3098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3098
ugucaaugua uuacuuaugc                                                   20


<210>  3099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3099
uccuuccacc ccuuuccucu                                                   20


<210>  3100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3100
ugccagauau aaccuguuca                                                   20


<210>  3101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3101
ggcaggauac augaggaacu                                                   20


<210>  3102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3102
uacaauauga acagguuaua                                                   20


<210>  3103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3103
aucuuacaau augaacaggu                                                   20


<210>  3104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3104
auauauuuuu ugagauguag                                                   20


<210>  3105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3105
caaaaaauau auagauauau                                                   20


<210>  3106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3106
cugcacucca gccuggguga                                                   20


<210>  3107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3107
cggcucacug cagucucugc                                                   20


<210>  3108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3108
cagcuacuca gaaggcugag                                                   20


<210>  3109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3109
cuacuaaaaa uacaaaaauu                                                   20


<210>  3110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3110
caaggucagg aguucaagac                                                   20


<210>  3111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3111
guccaccucg gccucccaaa                                                   20


<210>  3112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3112
cagcacuuug ggaggccgag                                                   20


<210>  3113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3113
acugcauuag guuuauuuau                                                   20


<210>  3114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3114
aaacuuugug agcaguguuu                                                   20


<210>  3115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3115
ucuucucaaa guaagauuga                                                   20


<210>  3116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3116
uacuuugaga agaggauuuu                                                   20


<210>  3117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3117
aucuuacuuu gagaagagga                                                   20


<210>  3118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3118
guucuguuuu uauggcucuu                                                   20


<210>  3119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3119
uguaugcuga gcagagcaca                                                   20


<210>  3120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3120
agcaugcuug ggaggguccu                                                   20


<210>  3121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3121
gaaggagaau aagaaacugc                                                   20


<210>  3122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3122
gguguuuccc ugacuuuauu                                                   20


<210>  3123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3123
guaaauauuu acuaaacaug                                                   20


<210>  3124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3124
ugcuuacugu cuauguccuu                                                   20


<210>  3125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3125
aucuugcuua cugucuaugu                                                   20


<210>  3126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3126
ccuucccugc uuugaaguuc                                                   20


<210>  3127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3127
aguguuaacu uauuuuuauu                                                   20


<210>  3128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3128
gccaggcugg agugcacuag                                                   20


<210>  3129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3129
cacuagugca cuccagccug                                                   20


<210>  3130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3130
uggcucacug caaccucugc                                                   20


<210>  3131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3131
cuugaaccca agaggcagag                                                   20


<210>  3132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3132
cagcuaaaca ggaggcugag                                                   20


<210>  3133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3133
cgccacugca cuccagccug                                                   20


<210>  3134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3134
cagcucacug caagcuccgc                                                   20


<210>  3135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3135
uggcuaacac ggugaaaccc                                                   20


<210>  3136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3136
uccuggcuaa cacggugaaa                                                   20


<210>  3137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3137
ugaucuccug accucgucau                                                   20


<210>  3138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3138
agaucauccu ggcuaacacg                                                   20


<210>  3139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3139
ccugaccucg ucauccgccg                                                   20


<210>  3140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3140
gccgaccuug ugauccgccc                                                   20


<210>  3141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3141
caaggucggc ggaugacgag                                                   20


<210>  3142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3142
gcccaccucg gccucccaaa                                                   20


<210>  3143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3143
cagcacuuug ggaggccgag                                                   20


<210>  3144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3144
cuacuaaaaa uacaaaaauu                                                   20


<210>  3145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3145
uggcaaaacc ccaucucuac                                                   20


<210>  3146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3146
caugaggccg ggaguucgag                                                   20


<210>  3147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3147
gccugccuug gccucccaaa                                                   20


<210>  3148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3148
uagcacuuug ggaggccaag                                                   20


<210>  3149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3149
acacuggcca gguauggugg                                                   20


<210>  3150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3150
cuaucguagc ucacuucagc                                                   20


<210>  3151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3151
uagcucacuu cagccuugaa                                                   20


<210>  3152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3152
cuugagccca ggaguucaag                                                   20


<210>  3153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3153
ucccaccuca accucacaau                                                   20


<210>  3154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3154
caccuggcca gaugauggcu                                                   20


<210>  3155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3155
ggccaggugu gauggcucac                                                   20


<210>  3156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3156
ucuggccagg ugugauggcu                                                   20


<210>  3157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3157
ggaauaccac uacuucauac                                                   20


<210>  3158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3158
uccuguuuca ggaauagcaa                                                   20


<210>  3159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3159
uugcuauucc ugaaacagga                                                   20


<210>  3160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3160
gaccaauacu acuugccuug                                                   20


<210>  3161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3161
acaaggcaag uaguauuggu                                                   20


<210>  3162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3162
uuauuccauc uacaaggcaa                                                   20


<210>  3163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3163
cacucacaua aaugccaaua                                                   20


<210>  3164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3164
caucucacuc acauaaaugc                                                   20


<210>  3165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3165
uccagugaca ucccaucuca                                                   20


<210>  3166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3166
ugcuacuccu cugcucuaau                                                   20


<210>  3167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3167
gaauuucaau cuuaagugaa                                                   20


<210>  3168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3168
uaagugaacu cuggcugaca                                                   20


<210>  3169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3169
gagcacugca guggcuuccu                                                   20


<210>  3170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3170
agucagucau uccucacacu                                                   20


<210>  3171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3171
gguuuguauu cagcugcaag                                                   20


<210>  3172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3172
ugcugcaaua gcuuaaacug                                                   20


<210>  3173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3173
gaagacaaaa auaagucugg                                                   20


<210>  3174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3174
uugcacucca gcccggguga                                                   20


<210>  3175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3175
caucauugca cuccagcccg                                                   20


<210>  3176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3176
cagcucacua aaaccucuac                                                   20


<210>  3177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3177
cuugaaccca ggagguagag                                                   20


<210>  3178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3178
caguuacuug ggaggcugag                                                   20


<210>  3179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3179
cuacuaaaaa cacaaaaauu                                                   20


<210>  3180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3180
ccugagguca gaaguucgag                                                   20


<210>  3181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3181
acucgccuca gccugccaaa                                                   20


<210>  3182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3182
cagcacuuug gcaggcugag                                                   20


<210>  3183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3183
agaauauaua aagaacuauu                                                   20


<210>  3184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3184
aguauccaga auauauaaag                                                   20


<210>  3185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3185
gauagaugau uuguaaaaac                                                   20


<210>  3186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3186
gauaagaauc caguauccag                                                   20


<210>  3187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3187
aucugauaag aauccaguau                                                   20


<210>  3188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3188
ucuaucugau aagaauccag                                                   20


<210>  3189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3189
aaaggaaggg agaguuuuua                                                   20


<210>  3190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3190
agaaaguaaa aagacaaucc                                                   20


<210>  3191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3191
aaauuaaaaa cuuuuacacu                                                   20


<210>  3192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3192
auuuugucuu ugguugcugu                                                   20


<210>  3193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3193
aagaaaucau ugucuaaucc                                                   20


<210>  3194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3194
uugucuaauc caaagucaaa                                                   20


<210>  3195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3195
aaagucaaaa agguuuacuc                                                   20


<210>  3196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3196
gacuuaaaug uaaaacucua                                                   20


<210>  3197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3197
auuuugaguu aauuuuuaua                                                   20


<210>  3198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3198
uaguacccuu guugaaaauu                                                   20


<210>  3199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3199
uccuuaauug uauaaauuua                                                   20


<210>  3200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3200
acauaaagac caacagguag                                                   20


<210>  3201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3201
ugugccagua ccauacaguc                                                   20


<210>  3202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3202
agacuguaug guacuggcac                                                   20


<210>  3203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3203
ugaaaaggaa caaaguugga                                                   20


<210>  3204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3204
aucuugaaaa ggaacaaagu                                                   20


<210>  3205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3205
uacaauucgu acggaaaugc                                                   20


<210>  3206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3206
gcuugucagu uucaacaaag                                                   20


<210>  3207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3207
uacuuggcuu cuuuguugaa                                                   20


<210>  3208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3208
cucucagaau ccuacuuggc                                                   20


<210>  3209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3209
guagaucaac uuggggagua                                                   20


<210>  3210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3210
acagauucaa cacaaucccu                                                   20


<210>  3211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3211
acuuggggag uauucgcauc                                                   20


<210>  3212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3212
uaacaauauu gucuuccacc                                                   20


<210>  3213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3213
gaccauuuac acaaaguuug                                                   20


<210>  3214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3214
caugacaggu gaaaauuaua                                                   20


<210>  3215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3215
aauacuaucu caugacaggu                                                   20


<210>  3216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3216
uauuuuaacc uaggaguggg                                                   20


<210>  3217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3217
cgccacugca cuccagccug                                                   20


<210>  3218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3218
cggcucacug caaccucugc                                                   20


<210>  3219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3219
cagcuacuag ggaggccgug                                                   20


<210>  3220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3220
ccugagguca ggaguucaag                                                   20


<210>  3221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3221
acccgccuca gccucccaaa                                                   20


<210>  3222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3222
cagcacuuug ggaggcugag                                                   20


<210>  3223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3223
ucaagcagca cagaugaaaa                                                   20


<210>  3224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3224
gugcugcuug aagauauuuu                                                   20


<210>  3225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3225
uugucuaacu uccuaagaac                                                   20


<210>  3226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3226
gggaagaaga cacaagaaac                                                   20


<210>  3227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3227
cagucaagca aacaaaaaau                                                   20


<210>  3228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3228
cauuacauau guauuuuuuu                                                   20


<210>  3229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3229
augacacauu guuaaguaaa                                                   20


<210>  3230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3230
ccaaaagucc ucuuuuaaaa                                                   20


<210>  3231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3231
ccaucaccuc cauuuccugu                                                   20


<210>  3232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3232
ccuccauuuc cuguaaauaa                                                   20


<210>  3233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3233
agugguugac uuauuuacag                                                   20


<210>  3234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3234
auucaaaggu aguuuaucaa                                                   20


<210>  3235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3235
acacucaaaa cauuuagucu                                                   20


<210>  3236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3236
aauuuaauac aauauuaaac                                                   20


<210>  3237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3237
auuugggggc uagaauguau                                                   20


<210>  3238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3238
ugucucuaac auacauucua                                                   20


<210>  3239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3239
cagugagguc ucagggacag                                                   20


<210>  3240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3240
uuugggaucu cauaagcaga                                                   20


<210>  3241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3241
caaaugauac caaacgacug                                                   20


<210>  3242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3242
cauaagcaga cucucucugc                                                   20


<210>  3243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3243
gagucugugu uuuaacaggu                                                   20


<210>  3244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3244
gcuguagggc cguugagcau                                                   20


<210>  3245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3245
cagcuacaga aaugcucaac                                                   20


<210>  3246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3246
aagcgagucc cacuaccaau                                                   20


<210>  3247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3247
gagcagccac uauggagaaa                                                   20


<210>  3248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3248
uuauuucugc ccuucaccuu                                                   20


<210>  3249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3249
cucgcagccu cauccuuauu                                                   20


<210>  3250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3250
uggugcacaa gacgcucguc                                                   20


<210>  3251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3251
uuuaaaaaca uaaauuaaac                                                   20


<210>  3252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3252
uuuuggcugg gcacaauggu                                                   20


<210>  3253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3253
ucccaccaca ccgucucaaa                                                   20


<210>  3254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3254
uccagccucc ucagccuccu                                                   20


<210>  3255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3255
uagcucacug cagccucaaa                                                   20


<210>  3256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3256
aaaugcauau auauacauau                                                   20


<210>  3257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3257
uuucaucuaa augcauauau                                                   20


<210>  3258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3258
cuuugacaau accacaugcu                                                   20


<210>  3259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3259
ucaccagcau gugguauugu                                                   20


<210>  3260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3260
ugggcauuaa uccuagagaa                                                   20


<210>  3261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3261
uagagaaaug aaaccuuaau                                                   20


<210>  3262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3262
aagaacugga aucagcucag                                                   20


<210>  3263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3263
gcucagaugu ccuucaacag                                                   20


<210>  3264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3264
gagcugauuc caguucuuag                                                   20


<210>  3265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3265
guagcucauu ccuuuuuauu                                                   20


<210>  3266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3266
caaaagguua uacauacugu                                                   20


<210>  3267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3267
uacaguaugu auaaccuuuu                                                   20


<210>  3268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3268
cuaaaacugu gccauugcaa                                                   20


<210>  3269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3269
auucuccauc ccuaaaacug                                                   20


<210>  3270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3270
cuaaccccag gcaaccacua                                                   20


<210>  3271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3271
ugccacugca cuccagccug                                                   20


<210>  3272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3272
uuucucacug caaccucugc                                                   20


<210>  3273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3273
cuugaaccca ggaggcagag                                                   20


<210>  3274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3274
aaauaaucca acacacauga                                                   20


<210>  3275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3275
aacacacaug acauuaaaac                                                   20


<210>  3276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3276
agaucagguc ggacguggug                                                   20


<210>  3277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3277
ugauguuuua augucaugug                                                   20


<210>  3278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3278
ggucggacgu gguggcucau                                                   20


<210>  3279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3279
cagcacuuuu gggaggccaa                                                   20


<210>  3280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3280
gcccaccuug gccucccaaa                                                   20


<210>  3281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3281
cuugagguca ggaguucgag                                                   20


<210>  3282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3282
uguuggcccg gcuggucucg                                                   20


<210>  3283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3283
ugacuaaaaa uacaaaaauu                                                   20


<210>  3284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3284
ccaaaaaaaa aaaaccaaga                                                   20


<210>  3285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3285
ugguuuuuuu uuuuuggaga                                                   20


<210>  3286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3286
auuaaaauac agcauuacug                                                   20


<210>  3287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3287
cagcacuuug ggaggccgag                                                   20


<210>  3288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3288
cggccuccca aagugcuggg                                                   20


<210>  3289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3289
gcccaucucg gccucccaaa                                                   20


<210>  3290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3290
cgaggucagg agauccagac                                                   20


<210>  3291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3291
ccugaccucg ugaucugccc                                                   20


<210>  3292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3292
agaccauccc ggcuaacacg                                                   20


<210>  3293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3293
cggcuaacac ggugaaaccc                                                   20


<210>  3294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3294
cagcucacug ccagcucugc                                                   20


<210>  3295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3295
cgccacugca cuccagccug                                                   20


<210>  3296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3296
gcacgggcac acaagcguaa                                                   20


<210>  3297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3297
agcaaucugc acgggcacac                                                   20


<210>  3298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3298
uccgccagcc uccucuaauu                                                   20


<210>  3299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3299
uggugcacug caaccucugc                                                   20


<210>  3300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3300
cagcuacucg ggaggcugcg                                                   20


<210>  3301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3301
gaggucagga guucgagacc                                                   20


<210>  3302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3302
ucugagguca ggaguucgag                                                   20


<210>  3303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3303
gcugccccag ccucccaaag                                                   20


<210>  3304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3304
cagcacuuug ggaggcuggg                                                   20


<210>  3305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3305
cuuuugguaa auguagucac                                                   20


<210>  3306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3306
ccauacuuac uuuucaugua                                                   20


<210>  3307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3307
guucaucauc uuaacuaaau                                                   20


<210>  3308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3308
ucuuaacuaa auuccauggg                                                   20


<210>  3309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3309
uaacuaaauu ccauggggga                                                   20


<210>  3310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3310
cauuuugucc aauaagcaaa                                                   20


<210>  3311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3311
aacuuaaaaa cacugccuug                                                   20


<210>  3312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3312
aaaacauagg accaacuaaa                                                   20


<210>  3313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3313
ccccucucua cuuuauuuug                                                   20


<210>  3314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3314
aaauaaagua gagaggggug                                                   20


<210>  3315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3315
gaagccauag guuuggaugg                                                   20


<210>  3316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3316
aaaccuaugg cuucagaugu                                                   20


<210>  3317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3317
uuagccugau caucuucgcc                                                   20


<210>  3318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3318
ggcuaaagau gccuccuucc                                                   20


<210>  3319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3319
ucuucgccag gcuguuuauc                                                   20


<210>  3320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3320
ucgccaggcu guuuaucucc                                                   20


<210>  3321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3321
ccuuuugcuu ggcugagaag                                                   20


<210>  3322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3322
acauaccaca cagaccucag                                                   20


<210>  3323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3323
uuaacugacu acaaucaaca                                                   20


<210>  3324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3324
cuuguaaucu augccaucau                                                   20


<210>  3325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3325
augccaucau cuucuguacu                                                   20


<210>  3326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3326
ucuucuguac ugcugagaaa                                                   20


<210>  3327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3327
ucuguacugc ugagaaagaa                                                   20


<210>  3328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3328
aacuauacca cugguuguaa                                                   20


<210>  3329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3329
uacaaccagu gguauaguuu                                                   20


<210>  3330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3330
cuaaagccaa acugcaucuu                                                   20


<210>  3331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3331
uguguuaaca ucacuaaagc                                                   20


<210>  3332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3332
auuucacguu ugaaucaugu                                                   20


<210>  3333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3333
ccucuguauu ucaccaauac                                                   20


<210>  3334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3334
gugugaucuu gggcauguca                                                   20


<210>  3335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3335
cacagauaug aagucauaca                                                   20


<210>  3336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3336
ugggcauguc augguuggca                                                   20


<210>  3337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3337
cagugcuuug ggaggccaag                                                   20


<210>  3338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3338
uggccuccca aagcacuggg                                                   20


<210>  3339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3339
ucccaucuug gccucccaaa                                                   20


<210>  3340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3340
cuugaggcca ggaguuugag                                                   20


<210>  3341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3341
ugaggccccg ucucuacaaa                                                   20


<210>  3342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3342
ucccgucuca gccuccugag                                                   20


<210>  3343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3343
uuucagccua ggaguuuaag                                                   20


<210>  3344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3344
uggcucacuu uagccuuaaa                                                   20


<210>  3345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3345
uacuccagcc ugggcagcag                                                   20


<210>  3346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3346
ugcucugcug cccaggcugg                                                   20


<210>  3347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3347
ugacucuaaa aaaaaguaaa                                                   20


<210>  3348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3348
ucuguuuuuu cugugagcag                                                   20


<210>  3349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3349
guuuuuucug ugagcagcgu                                                   20


<210>  3350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3350
ggacagggaa gcacagggca                                                   20


<210>  3351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3351
ccauucugcc cgcaacaugg                                                   20


<210>  3352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3352
uugucugaca auaugugaaa                                                   20


<210>  3353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3353
auuuaaaaua gcugggacac                                                   20


<210>  3354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3354
auuuaagaug aagaaggacc                                                   20


<210>  3355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3355
uaaauggauu ucugaaucca                                                   20


<210>  3356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3356
uuguauauag ccagaaauau                                                   20


<210>  3357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3357
agacacugaa augaauaaug                                                   20


<210>  3358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3358
uuuaugcaaa aauuaaaacc                                                   20


<210>  3359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3359
augguuugau auuuuugcau                                                   20


<210>  3360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3360
aaccauagau gguuuuaaaa                                                   20


<210>  3361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3361
cgaagcacag aggagugggc                                                   20


<210>  3362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3362
ccacuaaucc cgaagcacag                                                   20


<210>  3363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3363
uggggcauug acuguagguc                                                   20


<210>  3364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3364
agcaaggaaa gcugaccuac                                                   20


<210>  3365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3365
uucucacugg gaugaacuag                                                   20


<210>  3366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3366
cagugagaaa gaucaagcaa                                                   20


<210>  3367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3367
uucugaccgu uguuccuagu                                                   20


<210>  3368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3368
acagcuacua ggaacaacgg                                                   20


<210>  3369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3369
uaggugaaua ugucuccuac                                                   20


<210>  3370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3370
gaauucuguu acccacaugg                                                   20


<210>  3371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3371
ugauuuuagu acugacaaaa                                                   20


<210>  3372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3372
agauuauuug ucuaaaaauu                                                   20


<210>  3373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3373
ccacacguuu uugucaguac                                                   20


<210>  3374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3374
cgccauugca cuccagccug                                                   20


<210>  3375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3375
cggcucacug caaccucugc                                                   20


<210>  3376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3376
cuugaaccca ggaggcagag                                                   20


<210>  3377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3377
cuacuaaaaa uacaaaauua                                                   20


<210>  3378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3378
gccugaccaa caucucuacu                                                   20


<210>  3379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3379
cgaacuccca accuuaggug                                                   20


<210>  3380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3380
ccuaagguug ggaguucgag                                                   20


<210>  3381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3381
gcccgccuca gccucccaaa                                                   20


<210>  3382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3382
cagcacuuug ggaggcugag                                                   20


<210>  3383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3383
ccgggcgccc uggcucacgc                                                   20


<210>  3384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3384
ugacuccguc ucaaaaaaaa                                                   20


<210>  3385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3385
gucacccagg cuggagugca                                                   20


<210>  3386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3386
ugccacugca cuccagccug                                                   20


<210>  3387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3387
uggcuuacug caagcucugc                                                   20


<210>  3388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3388
cuacuaaaaa uacaaaaaau                                                   20


<210>  3389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3389
agaccacggu gaaaccccau                                                   20


<210>  3390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3390
ccugaccuca ugacccgcuc                                                   20


<210>  3391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3391
cagcacuuug ggaggcugag                                                   20


<210>  3392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3392
cugccaucua cuucauaagu                                                   20


<210>  3393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3393
acuucauaag uuuuucuucu                                                   20


<210>  3394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3394
gucuucauua aacucccuau                                                   20


<210>  3395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3395
uccauucuuu ccuguagucc                                                   20


<210>  3396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3396
auucuuuccu guagucccuu                                                   20


<210>  3397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3397
acuuacauga ggucuccaga                                                   20


<210>  3398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3398
uguaggaauc cacuuacaug                                                   20


<210>  3399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3399
ccaaaaaaaa aacacaaauc                                                   20


<210>  3400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3400
gcuuauuuuu aaugccucug                                                   20


<210>  3401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3401
cuuugaaagu auauaauaca                                                   20


<210>  3402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3402
uacacaguau uucacaaaca                                                   20


<210>  3403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3403
uagcguugua uucuacaaua                                                   20


<210>  3404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3404
cugcuaccug uguaagcugg                                                   20


<210>  3405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3405
aaagucaccc agcuuacaca                                                   20


<210>  3406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3406
cuaguuacac aguucuugug                                                   20


<210>  3407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3407
cacaagaacu guguaacuag                                                   20


<210>  3408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3408
gaugguacau gugaaacacu                                                   20


<210>  3409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3409
gaucccacaa gaacugugua                                                   20


<210>  3410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3410
augcaguugc uuuuucacag                                                   20


<210>  3411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3411
cauugcgaug cccaucaucc                                                   20


<210>  3412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3412
caaugggaua cgcuucccgc                                                   20


<210>  3413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3413
uccaaagcua uauguuaucu                                                   20


<210>  3414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3414
aaagcuauau guuaucuuua                                                   20


<210>  3415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3415
uuacuuuuuu uuuuuugaga                                                   20


<210>  3416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3416
cagcucacug caagcuccac                                                   20


<210>  3417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3417
cuacuaaaaa uacaaaaauu                                                   20


<210>  3418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3418
uggcuaacac ggugaaaccc                                                   20


<210>  3419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3419
agaccauccu ggcuaacacg                                                   20


<210>  3420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3420
ccugaccucg ugauccgccc                                                   20


<210>  3421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3421
cgaggucagg agaucaagac                                                   20


<210>  3422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3422
gcccgccucg gccucccaaa                                                   20


<210>  3423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3423
cagcacuuug ggaggccgag                                                   20


<210>  3424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3424
uuacuuuuuu ugugaaauga                                                   20


<210>  3425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3425
gaucuccacc auccaggucu                                                   20


<210>  3426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3426
gaugaacaau gaccaaaugu                                                   20


<210>  3427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3427
ccaccaucca ggucucagag                                                   20


<210>  3428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3428
aggucucaga gaacauaauu                                                   20


<210>  3429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3429
uauuuccugg gucaauaagc                                                   20


<210>  3430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3430
cuuucaaucu gagugcguca                                                   20


<210>  3431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3431
gagugcguca ggcuuuauuc                                                   20


<210>  3432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3432
aaagacaaaa ugacaagaau                                                   20


<210>  3433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3433
uaagauugau uugugguucu                                                   20


<210>  3434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3434
uaagaugucu caacauacuu                                                   20


<210>  3435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3435
aucuuaagau gucucaacau                                                   20


<210>  3436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3436
aaauaauagc uguuaauggu                                                   20


<210>  3437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3437
uaugaaacca agaauaaccu                                                   20


<210>  3438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3438
cuaaaaagua uagaguguau                                                   20


<210>  3439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3439
ccuucagcua uauacucuga                                                   20


<210>  3440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3440
cuguuuccug uuaacucucc                                                   20


<210>  3441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3441
auacuuagga accaguaacu                                                   20


<210>  3442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3442
aaaucaucug gaaaauuugu                                                   20


<210>  3443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3443
ucuggaaaau uuguuaaaaa                                                   20


<210>  3444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3444
ggaaaauuug uuaaaaauac                                                   20


<210>  3445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3445
ucuugggaau acccaggaau                                                   20


<210>  3446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3446
agguacauau uaguaagagg                                                   20


<210>  3447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3447
auagaucucc cauauauuag                                                   20


<210>  3448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3448
auggauuuuu guauauuuau                                                   20


<210>  3449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3449
cccauauauu agcauaaauc                                                   20


<210>  3450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3450
gcuagaaaau auaacguuua                                                   20


<210>  3451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3451
uuaaacguua uauuuucuag                                                   20


<210>  3452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3452
aguucacagu agcaccaaua                                                   20


<210>  3453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3453
aacucuaagg aaucgauaaa                                                   20


<210>  3454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3454
auaaauaugc aaaaacuuua                                                   20


<210>  3455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3455
auuccuuaga guucgauaua                                                   20


<210>  3456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3456
uucagaaaca uuaacagaag                                                   20


<210>  3457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3457
agaaaguggu caccuauauc                                                   20


<210>  3458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3458
uccuaucuag aaagugguca                                                   20


<210>  3459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3459
ugaucaaaau ucuaguagag                                                   20


<210>  3460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3460
agauuauuuu aaauuucugu                                                   20


<210>  3461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3461
aaauucuagu agagguauuu                                                   20


<210>  3462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3462
caaaaucauc accaggccug                                                   20


<210>  3463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3463
ucaccaggcc ugguguggug                                                   20


<210>  3464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3464
ccaggccugg ugugguggcc                                                   20


<210>  3465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3465
cagcacuuug ggaggcugag                                                   20


<210>  3466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3466
gccugccuca gccucccaaa                                                   20


<210>  3467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3467
ccugagguca agaguuugag                                                   20


<210>  3468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3468
aggcucaccg caaccuguac                                                   20


<210>  3469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3469
caccacugca uuccagccug                                                   20


<210>  3470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3470
acacuaauau ggugagacuu                                                   20


<210>  3471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3471
cuauuuuaau gucacauaca                                                   20


<210>  3472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3472
aaucacuauu uuaaugucac                                                   20


<210>  3473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3473
guaugaauuu augaugggug                                                   20


<210>  3474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3474
uaaauucaua cagauacaca                                                   20


<210>  3475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3475
uuucccucau uucccuaaua                                                   20


<210>  3476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3476
cuaccucaua uugcaaacaa                                                   20


<210>  3477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3477
gaacuuuaug uuuguuugca                                                   20


<210>  3478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3478
uaguuugagg aagguuaaca                                                   20


<210>  3479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3479
accuucaaca aaauugaaag                                                   20


<210>  3480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3480
auaugcuguc aauacuuucc                                                   20


<210>  3481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3481
aagguuacua gccuguguaa                                                   20


<210>  3482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3482
uuaagaaaaa cacugucgac                                                   20


<210>  3483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3483
gcuugaguuu cuauaacaaa                                                   20


<210>  3484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3484
guagacugaa acugaaacaa                                                   20


<210>  3485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3485
gaauauucuu aauguuugcc                                                   20


<210>  3486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3486
ccucugacaa aaaucugaau                                                   20


<210>  3487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3487
aaagcuuuau auuuucccaa                                                   20


<210>  3488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3488
uuacacacuu uccuaggggu                                                   20


<210>  3489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3489
cauuagaaaa uuaaaaauaa                                                   20


<210>  3490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3490
ccuuuuagug guaggccauu                                                   20


<210>  3491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3491
uaaauuuuca auccccuuuu                                                   20


<210>  3492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3492
caauaaacac auaaauaaau                                                   20


<210>  3493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3493
caccauugca cucuggccca                                                   20


<210>  3494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3494
cggcucacug caaccucugc                                                   20


<210>  3495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3495
caugaacccg ggaagcagag                                                   20


<210>  3496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3496
cagcuacuca ggaggcugag                                                   20


<210>  3497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3497
cuacuaaaaa uacaaaaaau                                                   20


<210>  3498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3498
ugaggucagg aguucgagac                                                   20


<210>  3499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3499
gcgccccucg gccucccagu                                                   20


<210>  3500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3500
caacacuggg aggccgaggg                                                   20


<210>  3501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3501
ggccaggcgc aguggcucac                                                   20


<210>  3502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3502
augaauguua acuaacauuc                                                   20


<210>  3503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3503
ugucucuaaa aaaaauuuuu                                                   20


<210>  3504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3504
uacucuguca cccaggcagg                                                   20


<210>  3505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3505
ugccugggug acagaguaag                                                   20


<210>  3506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3506
uagcccacug cagccugaac                                                   20


<210>  3507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3507
cuuaagccca ggaguucagg                                                   20


<210>  3508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3508
uucugccuca gccuuuugag                                                   20


<210>  3509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3509
auaaaacauu uaaaaauuag                                                   20


<210>  3510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3510
caucuauaaa acauuuaaaa                                                   20


<210>  3511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3511
ugcuguauug cccaggcugg                                                   20


<210>  3512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3512
cuugggccca ggaauucuag                                                   20


<210>  3513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3513
ucccaccuug gccucccaaa                                                   20


<210>  3514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3514
cagcgcuuug ggaggccaag                                                   20


<210>  3515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3515
auuggucaga agugguggcu                                                   20


<210>  3516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3516
uucauuauuu uuuaacugaa                                                   20


<210>  3517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3517
uagccagaag caaaaaucuu                                                   20


<210>  3518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3518
ucuugccuug aaauaguuga                                                   20


<210>  3519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3519
ggcaaagaag aauaguuauc                                                   20


<210>  3520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3520
caggaaaaug aauguggaga                                                   20


<210>  3521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3521
cugcacuccc agcucugccu                                                   20


<210>  3522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3522
uuucaggugg cucuaccucc                                                   20


<210>  3523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3523
caccaguugg aguggaaaac                                                   20


<210>  3524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3524
cuuuuuaaua uuagguaggg                                                   20


<210>  3525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3525
uuuggggaaa gaggggagca                                                   20


<210>  3526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3526
aguccuaauc ccuggagccu                                                   20


<210>  3527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3527
cuggagccug uaaauauuac                                                   20


<210>  3528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3528
uaaaacaauu uuccauauaa                                                   20


<210>  3529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3529
caucauaaaa caauuuucca                                                   20


<210>  3530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3530
ugaauuuaau cacaucauaa                                                   20


<210>  3531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3531
ugagaugagg gggcuaucuu                                                   20


<210>  3532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3532
caagauccug aauuuaauca                                                   20


<210>  3533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3533
uggaugaucu ggguaggcac                                                   20


<210>  3534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3534
aagauagccc ccucaucuca                                                   20


<210>  3535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3535
uccaagauag cccccucauc                                                   20


<210>  3536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3536
ggguaggcac uaaaugcaau                                                   20


<210>  3537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3537
cauauauaua aaaaggaggc                                                   20


<210>  3538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3538
cccucugccu ccuuuuuaua                                                   20


<210>  3539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3539
ucacagggcc uucucucugu                                                   20


<210>  3540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3540
uucuguucca ucuucacagg                                                   20


<210>  3541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3541
cuccaauuuu caaggccagc                                                   20


<210>  3542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3542
uaaaaaaaaa aaaaaaaaag                                                   20


<210>  3543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3543
uuuaccccuu uaaguugguu                                                   20


<210>  3544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3544
auaaauacua aaaaaaaaaa                                                   20


<210>  3545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3545
uucuugggug uuucuuggag                                                   20


<210>  3546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3546
cccucuccaa gaaacaccca                                                   20


<210>  3547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3547
gcugaccuuc ccuccacuau                                                   20


<210>  3548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3548
caaguaccca gggacacaaa                                                   20


<210>  3549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3549
ccacucccua aucucaagua                                                   20


<210>  3550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3550
guuuaacaaa gcacaucuug                                                   20


<210>  3551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3551
ugcaccgccc uuaauccauu                                                   20


<210>  3552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3552
auuuaacccu uaguggacac                                                   20


<210>  3553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3553
auaaccuuac ccccaacccc                                                   20


<210>  3554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3554
caaggcagaa gaauuuuucu                                                   20


<210>  3555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3555
gaucucucuu ucuuuuccca                                                   20


<210>  3556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3556
gauuguuacu gugucugcgu                                                   20


<210>  3557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3557
cucuuucuuu ucccacauuu                                                   20


<210>  3558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3558
uggacuguuc ucaaugagcu                                                   20


<210>  3559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3559
gggaggugua cccaauagcu                                                   20


<210>  3560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3560
gggaagugag gagccccucu                                                   20


<210>  3561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3561
cagacggggc ggcggggcag                                                   20


<210>  3562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3562
ucugggaagu ggggagcacc                                                   20


<210>  3563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3563
cugcccggcc gcccaucguc                                                   20


<210>  3564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3564
aggaagugag gagcaucucu                                                   20


<210>  3565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3565
caucuaggaa gugaggagca                                                   20


<210>  3566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3566
cagacgaugg gcggccaggc                                                   20


<210>  3567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3567
ucugggaugu gaggagcccc                                                   20


<210>  3568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3568
uggcacuuug ggaggccaag                                                   20


<210>  3569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3569
cgggucacua caaccuucac                                                   20


<210>  3570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3570
cgccacugca cuccagccug                                                   20


<210>  3571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3571
cggcaccucg ggaggccgag                                                   20


<210>  3572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3572
gccagccucg gccucccgag                                                   20


<210>  3573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3573
cuugcaguca ggagcuggag                                                   20


<210>  3574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3574
caggcacuug gcaggcugag                                                   20


<210>  3575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3575
gguagggagg uugcagugag                                                   20


<210>  3576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3576
cuacucacug caaccucccu                                                   20


<210>  3577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3577
gagggagacu gugcgagggc                                                   20


<210>  3578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3578
cuaaacugaa auuaaggaau                                                   20


<210>  3579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3579
accuuauuac accauuucac                                                   20


<210>  3580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3580
caaucuaccu uauuacacca                                                   20


<210>  3581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3581
ucaucacaau cuaccuuauu                                                   20


<210>  3582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3582
ccuuuuuugg uucauuagcu                                                   20


<210>  3583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3583
caaagaagcc agaaauaggg                                                   20


<210>  3584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3584
agcucuuucu uuccuuuauu                                                   20


<210>  3585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3585
accaucaagc ucuuucuuuc                                                   20


<210>  3586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3586
cugccuuuua cauguaaugu                                                   20


<210>  3587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3587
gaaaaaucgc ugccuuuuac                                                   20


<210>  3588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3588
aauucuugua agcacaguga                                                   20


<210>  3589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3589
gacaaagugg auuucaaagc                                                   20


<210>  3590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3590
acuuugucug auauuaacag                                                   20


<210>  3591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3591
ugggcaagag ccuuugcuuu                                                   20


<210>  3592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3592
cauccugggc aagagccuuu                                                   20


<210>  3593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3593
uuaugaaaug accaucucau                                                   20


<210>  3594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3594
ccuucaucau uaugaaauga                                                   20


<210>  3595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3595
gccuggcaua gcaagcugaa                                                   20


<210>  3596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3596
acagugauag agauuucagu                                                   20


<210>  3597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3597
cuguggauuu gucuguuucu                                                   20


<210>  3598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3598
cuaucacugu ggauuugucu                                                   20


<210>  3599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3599
uugagagcgg cuacugaaau                                                   20


<210>  3600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3600
ggaucuagaa cacuugacca                                                   20


<210>  3601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3601
agauauuaug gcuacguguu                                                   20


<210>  3602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3602
agaacacuug accaacacug                                                   20


<210>  3603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3603
uggcaaacau ucugugagca                                                   20


<210>  3604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3604
gcucuaucuu ggcaaacauu                                                   20


<210>  3605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3605
uuaaguugga auauauuaua                                                   20


<210>  3606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3606
uccuauaaua uauuccaacu                                                   20


<210>  3607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3607
gaggcuuuuc cagguuaucu                                                   20


<210>  3608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3608
aaaagacuuu caaauuuccc                                                   20


<210>  3609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3609
gucaauccaa aagacuuuca                                                   20


<210>  3610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3610
auuguuuuua uaucagucaa                                                   20


<210>  3611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3611
uucuuuccua aaacaggcau                                                   20


<210>  3612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3612
augaccucag cuucuaccuu                                                   20


<210>  3613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3613
agaguuacca gaagggccag                                                   20


<210>  3614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3614
accugccucg gccucccaaa                                                   20


<210>  3615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3615
acaaaaaaca aaaaaauuag                                                   20


<210>  3616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3616
ucccaccuua gacuccuggu                                                   20


<210>  3617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3617
caguucacug cagccucaac                                                   20


<210>  3618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3618
ugggcaacag aaugagaccc                                                   20


<210>  3619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3619
uaaagauagg agcagaaguc                                                   20


<210>  3620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3620
uuaugauguc cauucuucua                                                   20


<210>  3621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3621
auaaaaccaa aagcugguuc                                                   20


<210>  3622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3622
agaacaucaa uaaauuggua                                                   20


<210>  3623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3623
auaaauuggu aaagcugaua                                                   20


<210>  3624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3624
gcuuuaccaa uuuauugaug                                                   20


<210>  3625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3625
ggaaugaggg agaugacagu                                                   20


<210>  3626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3626
cccucauucc ugauauugcu                                                   20


<210>  3627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3627
auacuacugu caucucccuc                                                   20


<210>  3628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3628
auauaaucua uacuacuguc                                                   20


<210>  3629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3629
cagcaccuug ggaggccgag                                                   20


<210>  3630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3630
guccaccucg gccucccaag                                                   20


<210>  3631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3631
ccugagguca ggaguuuggg                                                   20


<210>  3632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3632
cagcuacuug ggaggcugag                                                   20


<210>  3633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3633
cagcucacug caaccuccgc                                                   20


<210>  3634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3634
caaaacaaau aaauaaauaa                                                   20


<210>  3635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3635
auaaguuguc aaauuuauug                                                   20


<210>  3636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3636
auuucaucua uaaguuguca                                                   20


<210>  3637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3637
ucuugagaga gcuuuaauag                                                   20


<210>  3638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3638
auaucuucuu gagagagcuu                                                   20


<210>  3639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3639
gcuuaucuau aucuucuuga                                                   20


<210>  3640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3640
auuuuauuga auuuaaaugu                                                   20


<210>  3641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3641
auauuuaguu acuggaaaac                                                   20


<210>  3642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3642
cagguaaagg uuuucugaug                                                   20


<210>  3643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3643
gaaaaccuuu accugugauu                                                   20


<210>  3644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3644
caauucagac acuaaauuuu                                                   20


<210>  3645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3645
uaauuauuuc uucacauuaa                                                   20


<210>  3646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3646
ugccuguuuu cuuuuuacuu                                                   20


<210>  3647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3647
aaaguaaaaa gaaaacaggc                                                   20


<210>  3648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3648
uucaaacacu gugcuccaaa                                                   20


<210>  3649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3649
aucauuucaa agaccuuucc                                                   20


<210>  3650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3650
uuucaaagac cuuuccucag                                                   20


<210>  3651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3651
auguggaaua cagacagcca                                                   20


<210>  3652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3652
acaaacuuau aaaagcauaa                                                   20


<210>  3653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3653
uuacugaugu ggacuuuugg                                                   20


<210>  3654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3654
guaaugauca acaaacuuau                                                   20


<210>  3655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3655
uccaaccauu guuugcaauu                                                   20


<210>  3656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3656
cuagguaaaa auugcaaaca                                                   20


<210>  3657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3657
aacuacucug aaaccaaaug                                                   20


<210>  3658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3658
caaucuaacu acucugaaac                                                   20


<210>  3659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3659
ugaaagagca accucauuuu                                                   20


<210>  3660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3660
aaaugagguu gcucuuucau                                                   20


<210>  3661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3661
cccguauuac ugggauuugc                                                   20


<210>  3662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3662
caguaauacg ggggaugugc                                                   20


<210>  3663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3663
caagaauagc aaaucccagu                                                   20


<210>  3664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3664
uuguguuacu gguuuggaug                                                   20


<210>  3665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3665
aaaccaguaa cacaaggaug                                                   20


<210>  3666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3666
guuuagcucu cucuuggcuu                                                   20


<210>  3667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3667
ugcuccaacu gucuaaacaa                                                   20


<210>  3668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3668
gaccaugauc aucuggcauc                                                   20


<210>  3669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3669
uggucagauu guguuuuugu                                                   20


<210>  3670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3670
ucuggcaucu uagggugaaa                                                   20


<210>  3671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3671
ggcaucuuag ggugaaauau                                                   20


<210>  3672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3672
uagggugaaa uaugguuaua                                                   20


<210>  3673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3673
ugcuuucggu augggccaaa                                                   20


<210>  3674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3674
cuccugcccc uuuuuaaucu                                                   20


<210>  3675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3675
guucagcagu cuaucucucc                                                   20


<210>  3676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3676
uagacaaccc acugcuuucu                                                   20


<210>  3677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3677
gaaguuuuua aacgaaaauu                                                   20


<210>  3678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3678
cuucuuuuuu aaaaaauaaa                                                   20


<210>  3679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3679
aaaacuauuu caaaauaaag                                                   20


<210>  3680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3680
aauuuuuuuc uauaaaucua                                                   20


<210>  3681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3681
aguuacccca guuauuauca                                                   20


<210>  3682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3682
uccuaauuua gugugagaca                                                   20


<210>  3683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3683
uaauuuagug ugagacauuu                                                   20


<210>  3684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3684
auauugauau gcuauuaacu                                                   20


<210>  3685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3685
auauugauuc auuaaacaug                                                   20


<210>  3686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3686
gaauaaaguc uggacuuaag                                                   20


<210>  3687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3687
gguguccugc auggaauucu                                                   20


<210>  3688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3688
cuauggaacu uuuucugcug                                                   20


<210>  3689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3689
cugcacagca gaaaaaguuc                                                   20


<210>  3690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3690
gacucugcgu caucacugca                                                   20


<210>  3691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3691
ugacaucuga cucugcguca                                                   20


<210>  3692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3692
aaguaagaac cguguggaug                                                   20


<210>  3693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3693
acacgguucu uacuuugaua                                                   20


<210>  3694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3694
uccacacggu ucuuacuuug                                                   20


<210>  3695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3695
uuguuguagg cugagagaag                                                   20


<210>  3696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3696
cuucuucucu cagccuacaa                                                   20


<210>  3697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3697
uugaguguuc uucuguuuug                                                   20


<210>  3698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3698
ucagggacuc aaaacagaag                                                   20


<210>  3699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3699
gaaaggaaaa aagugcagac                                                   20


<210>  3700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3700
ccaaaccaua caagagcacc                                                   20


<210>  3701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3701
ccaaaccaua caauagagca                                                   20


<210>  3702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3702
gccugcauug cuugccacac                                                   20


<210>  3703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3703
guucccuuca uugaccuagg                                                   20


<210>  3704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3704
aguggcuacc aucgguuccc                                                   20


<210>  3705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3705
cauuuuaugg uuaagaaaac                                                   20


<210>  3706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3706
auguuuuugu ggcaugugua                                                   20


<210>  3707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3707
ucacacauac acagacacac                                                   20


<210>  3708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3708
aguaguggca auuaguccuc                                                   20


<210>  3709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3709
ucaaaguggu aagaaguguu                                                   20


<210>  3710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3710
uuacacucuu acccagcaag                                                   20


<210>  3711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3711
ugcuggguaa gaguguaagg                                                   20


<210>  3712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3712
aucuugcugg guaagagugu                                                   20


<210>  3713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3713
caugguuucc augguauccu                                                   20


<210>  3714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3714
uuuugcccag ggaaucuuug                                                   20


<210>  3715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3715
uugcuuugug gcuagcacuu                                                   20


<210>  3716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3716
cgcuuucugu ggucaggacg                                                   20


<210>  3717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3717
cauggcucca gagaagccag                                                   20


<210>  3718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3718
cacuuaugca gugacguaua                                                   20


<210>  3719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3719
guuucaccuu guucuccgug                                                   20


<210>  3720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3720
gcaggcacgg agaacaaggu                                                   20


<210>  3721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3721
uuggcaccac uugcauggug                                                   20


<210>  3722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3722
uugcuugcuu cuuuuauucu                                                   20


<210>  3723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3723
gccacugcac uccagccugg                                                   20


<210>  3724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3724
cggcucauug cagccuugag                                                   20


<210>  3725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3725
uccuggcuug gccccuugag                                                   20


<210>  3726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3726
cuacaaauaa uuuuaaaaau                                                   20


<210>  3727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3727
caucucuaca aauaauuuua                                                   20


<210>  3728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3728
cgccagguug cccaggcugg                                                   20


<210>  3729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3729
cuugagccca ggcguucaag                                                   20


<210>  3730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3730
ucccuccuug guuucccaaa                                                   20


<210>  3731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3731
cagcacuuug ggaaaccaag                                                   20


<210>  3732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3732
caggugugag ccacugugcc                                                   20


<210>  3733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3733
agggccaggc acaguggcuc                                                   20


<210>  3734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3734
agaacugaaa caucaagggc                                                   20


<210>  3735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3735
aauaucaaga acugaaacau                                                   20


<210>  3736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3736
ucagagucag aaaaucuaaa                                                   20


<210>  3737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3737
aaaaagaggg cuaucccagg                                                   20


<210>  3738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3738
cagguugccu ugguucaugg                                                   20


<210>  3739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3739
gagagcagcc aaacccugcu                                                   20


<210>  3740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3740
gaggaagcag gaaucugaga                                                   20


<210>  3741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3741
cgcugccagc ccgcugggcc                                                   20


<210>  3742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3742
ggaucuggcu agguuugcuc                                                   20


<210>  3743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3743
ugaucccgcu gccagcccgc                                                   20


<210>  3744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3744
ggcuagguuu gcucucacug                                                   20


<210>  3745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3745
gacauagccu ggcagcaugc                                                   20


<210>  3746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3746
ccaccaccgu caagaggcug                                                   20


<210>  3747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3747
cuucagccuc uugacggugg                                                   20


<210>  3748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3748
acucuuucac cuacuggcug                                                   20


<210>  3749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3749
ucaccgccuc uugucucaag                                                   20


<210>  3750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3750
ccgccucuug ucucaagggg                                                   20


<210>  3751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3751
uaugcugcca gagaguggga                                                   20


<210>  3752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3752
aaagucuuca agagccccua                                                   20


<210>  3753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3753
uuuaggaaga gugacccggu                                                   20


<210>  3754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3754
uggcucgagg cccugcacuc                                                   20


<210>  3755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3755
cccagcgacu ggcguagauu                                                   20


<210>  3756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3756
acgccagucg cugggugaug                                                   20


<210>  3757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3757
agguuugaua aggcuucuag                                                   20


<210>  3758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3758
aaccuugauu uagcuuuaca                                                   20


<210>  3759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3759
uguuguugca guuuguacug                                                   20


<210>  3760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3760
uaauccuguu guugcaguuu                                                   20


<210>  3761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3761
cagaaacguu uaaauccuaa                                                   20


<210>  3762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3762
cauucuggga aauucugagg                                                   20


<210>  3763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3763
gguuuugauu uucaagcuug                                                   20


<210>  3764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3764
aaaccagauc acauucuggg                                                   20


<210>  3765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3765
caguccacuu acaucaacug                                                   20


<210>  3766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3766
acugcccaug ccacgguuaa                                                   20


<210>  3767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3767
cuuuaaccgu ggcaugggca                                                   20


<210>  3768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3768
ucgacugaug uuuggcacag                                                   20


<210>  3769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3769
acugauguuu ggcacagcuu                                                   20


<210>  3770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3770
gucgaugauc ucuuuaaccg                                                   20


<210>  3771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3771
ccuagcuuga gaagcccuuc                                                   20


<210>  3772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3772
uuacuagcuu gaaguugacc                                                   20


<210>  3773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3773
ggacguacuu ucugguuuag                                                   20


<210>  3774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3774
cucaacccuc cuugcucacu                                                   20


<210>  3775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3775
uuuucugcag guguggcccc                                                   20


<210>  3776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3776
gcaggguccc gagcacugug                                                   20


<210>  3777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3777
uccaacagaa uguucugcua                                                   20


<210>  3778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3778
aacagaaugu ucugcuagug                                                   20


<210>  3779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3779
ucacuagcag aacauucugu                                                   20


<210>  3780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3780
uuaaucuuca cuagcagaac                                                   20


<210>  3781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3781
uaaagccccu ggaguaaauc                                                   20


<210>  3782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3782
uauauauaua auuuuuuuuu                                                   20


<210>  3783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3783
caaaaaaaaa aaaaaaaaaa                                                   20


<210>  3784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3784
cgccauugca cuccagccug                                                   20


<210>  3785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3785
uggcucacug caaccuccgc                                                   20


<210>  3786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3786
cagcuacucg agaggcugag                                                   20


<210>  3787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3787
ccugagguca ggaguucaag                                                   20


<210>  3788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3788
gcccgccuug gccucccaaa                                                   20


<210>  3789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3789
cagcacuuug ggaggccaag                                                   20


<210>  3790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3790
uggccaggug ggguggcuca                                                   20


<210>  3791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3791
accauuuuaa uuuugauguu                                                   20


<210>  3792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3792
aaauuaaaau gguagauggu                                                   20


<210>  3793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3793
aauacuacau aacaucaaaa                                                   20


<210>  3794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3794
ucaaauacua cauaacauca                                                   20


<210>  3795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3795
aguuuauuca guaacuuccu                                                   20


<210>  3796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3796
uaguuuccuu uuagcucguu                                                   20


<210>  3797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3797
cuaguucuaa aacgagcuaa                                                   20


<210>  3798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3798
caucacuagu ucuaaaacga                                                   20


<210>  3799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3799
cuugugauuu guuguaggcu                                                   20


<210>  3800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3800
caagagauuu auggaagaca                                                   20


<210>  3801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3801
aagccuacaa caaaucacaa                                                   20


<210>  3802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3802
aucaaagccu acaacaaauc                                                   20


<210>  3803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3803
uccaagguua cagcucgagc                                                   20


<210>  3804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3804
cauguacccc auaaauauau                                                   20


<210>  3805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3805
aaauaucuca uguaccccau                                                   20


<210>  3806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3806
caccauggaa aguuggauau                                                   20


<210>  3807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3807
aacuuuccau ggugugauua                                                   20


<210>  3808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3808
augcccucaa gcauuuaucc                                                   20


<210>  3809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3809
uuuguguuac aaacaaucca                                                   20


<210>  3810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3810
aguuacaugc uuuacuuauu                                                   20


<210>  3811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3811
ccugagguca ggaguuugag                                                   20


<210>  3812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3812
gcccgccucg gccucccaaa                                                   20


<210>  3813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3813
caacacuuug ggaggccgag                                                   20


<210>  3814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3814
ggcccggcac aguggcucac                                                   20


<210>  3815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3815
cagcauuuug ggaggcugag                                                   20


<210>  3816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3816
ccugccucag ccucccaaaa                                                   20


<210>  3817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3817
ccugagauca ggaguucgag                                                   20


<210>  3818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3818
caggugauca ccugccucag                                                   20


<210>  3819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3819
ggaguucgag accagccugg                                                   20


<210>  3820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3820
uggcuacucg ggaggcugag                                                   20


<210>  3821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3821
cuugaaccug gggguggagg                                                   20


<210>  3822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3822
cggcucacug caaccuccac                                                   20


<210>  3823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3823
cgccacugca uuccagccug                                                   20


<210>  3824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3824
accugccuca gguucccaaa                                                   20


<210>  3825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3825
cccaaguagc ugagacuaua                                                   20


<210>  3826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3826
ucccaccuca aucucccaag                                                   20


<210>  3827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3827
auagguagcu gagauugugc                                                   20


<210>  3828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3828
cagcuaccua uagauucaac                                                   20


<210>  3829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3829
acuauauauu auugucuaug                                                   20


<210>  3830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3830
uagacaauaa uauauagucg                                                   20


<210>  3831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3831
cucugcugug cugucgaaua                                                   20


<210>  3832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3832
cugagcaaac uucacucugu                                                   20


<210>  3833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3833
cacaccugcu gcuuaacaga                                                   20


<210>  3834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3834
uuauucagua auucacaaug                                                   20


<210>  3835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3835
ucuaccaaac agcauuuccu                                                   20


<210>  3836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3836
aauaaagagu aaccuuuuga                                                   20


<210>  3837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3837
caucuaauaa agaguaaccu                                                   20


<210>  3838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3838
uuauaauuga agcccacuag                                                   20


<210>  3839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3839
gguaacuacu uuaaggucua                                                   20


<210>  3840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3840
agaguguaca acuuaccugc                                                   20


<210>  3841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3841
guagcagcug gcccccgaca                                                   20


<210>  3842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3842
uuuaugucuc agcucagaug                                                   20


<210>  3843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3843
gagcugagac auaaaggauc                                                   20


<210>  3844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3844
augucagaaa uugucacgua                                                   20


<210>  3845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3845
gugugcuugu uuauuuucua                                                   20


<210>  3846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3846
cacccuuccg caagagacuu                                                   20


<210>  3847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3847
cauaagucuc uugcggaagg                                                   20


<210>  3848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3848
cugcugggcu gcaacagagc                                                   20


<210>  3849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3849
uuuaagcaag uacuaugugc                                                   20


<210>  3850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3850
auuugucugu uacaugaguu                                                   20


<210>  3851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3851
uaacggauug agaaacaaaa                                                   20


<210>  3852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3852
guuaagauac aacuguuuug                                                   20


<210>  3853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3853
gcucccuccu ucuccuuaac                                                   20


<210>  3854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3854
gcauguauug cugguuaagg                                                   20


<210>  3855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3855
gcaucagcau guauugcugg                                                   20


<210>  3856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3856
cauagacccu cagcuccauc                                                   20


<210>  3857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3857
ugagucacug ggaauguggu                                                   20


<210>  3858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3858
uauauggguc gggcauagug                                                   20


<210>  3859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3859
aagguaugag ccacuaugcc                                                   20


<210>  3860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3860
cagcacuuca ggaggccaag                                                   20


<210>  3861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3861
accugccuug gccuccugaa                                                   20


<210>  3862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3862
ucccaccuca gccucucgag                                                   20


<210>  3863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3863
cuugagccug ggagguggag                                                   20


<210>  3864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3864
uggcucaaca cgaccuccac                                                   20


<210>  3865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3865
caccacugca cuccagccug                                                   20


<210>  3866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3866
agaaaagaac uuauauggcu                                                   20


<210>  3867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3867
cuaaggaaau uuccuuuugu                                                   20


<210>  3868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3868
uuuuucuuuu acuaucauuu                                                   20


<210>  3869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3869
uuuaaaaaaa uguguuauau                                                   20


<210>  3870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3870
agguucugca cauagcagcc                                                   20


<210>  3871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3871
aaacggcacu gggaaauggg                                                   20


<210>  3872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3872
cuaucuaaac ggcacuggga                                                   20


<210>  3873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3873
gacuaaugag ucaaugcagg                                                   20


<210>  3874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3874
ggaggaagaa aaaccugacu                                                   20


<210>  3875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3875
caggaauuca cccaacacac                                                   20


<210>  3876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3876
gugacucacu gcucuguguc                                                   20


<210>  3877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3877
uaauacuucu uaaaacacuc                                                   20


<210>  3878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3878
aaaaggcugg guuuaaaaau                                                   20


<210>  3879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3879
ucugugauca uaagagaaau                                                   20


<210>  3880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3880
cagaggaucu aaaaggcugg                                                   20


<210>  3881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3881
uaagagaaau gaaggauguc                                                   20


<210>  3882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3882
uucauuucuc uuaugaucac                                                   20


<210>  3883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3883
acauuucauc cuccuguucu                                                   20


<210>  3884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3884
uccuguucuu ucagcugagu                                                   20


<210>  3885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3885
cauuagggac uguuggaaua                                                   20


<210>  3886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3886
guccaggaga ccuuggcugc                                                   20


<210>  3887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3887
uaccuuaauu ucauugucau                                                   20


<210>  3888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3888
cucgcauguu ugugaccuga                                                   20


<210>  3889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3889
uuuguguuau uuuugaggca                                                   20


<210>  3890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3890
cccaauucaa cucuucaccc                                                   20


<210>  3891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3891
agaaaccauc ucccaauuca                                                   20


<210>  3892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3892
gcucuggaaa aaugccuuuu                                                   20


<210>  3893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3893
ucccgcagcu agguuaaaga                                                   20


<210>  3894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3894
gagccuguug gcuuccuguu                                                   20


<210>  3895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3895
ucuucaaacc cacuuuagug                                                   20


<210>  3896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3896
ucaaacccac uuuaguguuu                                                   20


<210>  3897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3897
guagagcaug ugacaggguc                                                   20


<210>  3898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3898
uguaaucugu agagcaugug                                                   20


<210>  3899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3899
ccucccagga gggucacuug                                                   20


<210>  3900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3900
ucaccuccca ggagggucac                                                   20


<210>  3901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3901
gauggacuug gauuagaauu                                                   20


<210>  3902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3902
gauuccacuc uacccagugu                                                   20


<210>  3903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3903
aaguccaucu gauuccacuc                                                   20


<210>  3904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3904
aagcccuucc cgugggugac                                                   20


<210>  3905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3905
uucagcuaau aagagcagua                                                   20


<210>  3906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3906
ccuuaguauu aacaagaaaa                                                   20


<210>  3907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3907
cccuucguca uuccaaaacc                                                   20


<210>  3908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3908
ucucccuucg ucauuccaaa                                                   20


<210>  3909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3909
aaagaauuua guguaauauu                                                   20


<210>  3910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3910
cuuuggaaug ggaguaggug                                                   20


<210>  3911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3911
guacacuggg gucuguugaa                                                   20


<210>  3912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3912
cagaggggac ugccuucaac                                                   20


<210>  3913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3913
cuggcuguca gagcucagau                                                   20


<210>  3914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3914
gagcucugac agccagagau                                                   20


<210>  3915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3915
ucugagcucu gacagccaga                                                   20


<210>  3916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3916
aucaucugag cucugacagc                                                   20


<210>  3917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3917
uuuucaugau uucgaucacc                                                   20


<210>  3918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3918
ugaaaaugau gagaacuaag                                                   20


<210>  3919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3919
aaaucaugaa aaugaugaga                                                   20


<210>  3920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3920
ccauuugagu augaugaugc                                                   20


<210>  3921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3921
uacucaaaug gugaucgaaa                                                   20


<210>  3922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3922
ucauacucaa auggugaucg                                                   20


<210>  3923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3923
guuaauuacu uccuuccuga                                                   20


<210>  3924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3924
auucugcuac cucucugcuc                                                   20


<210>  3925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3925
agagccuggu acaguggcuu                                                   20


<210>  3926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3926
uccuaccuca gccucccaag                                                   20


<210>  3927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3927
ugcccaggcu ggucucaaac                                                   20


<210>  3928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3928
cuaaaaaaac ugaaaaaaaa                                                   20


<210>  3929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3929
uguccagcua auuuuuuuuc                                                   20


<210>  3930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3930
cagcucagug uagccucgaa                                                   20


<210>  3931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3931
uguuuuacca cccaugcugg                                                   20


<210>  3932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3932
augaaauuca guaguaccaa                                                   20


<210>  3933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3933
uguugguacu acugaauuuc                                                   20


<210>  3934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3934
uuguuuauaa uccuguuggu                                                   20


<210>  3935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3935
uugugucuca caggcaaaca                                                   20


<210>  3936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3936
caaagaaaaa aaaagaaaga                                                   20


<210>  3937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3937
uggcucacca caaccucugu                                                   20


<210>  3938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3938
cuugaacccg ggagacagag                                                   20


<210>  3939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3939
cagcuacuag gaggcugagg                                                   20


<210>  3940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3940
ccacgcucgg cuaauuuugu                                                   20


<210>  3941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3941
cuacuaaaag uacaaaauua                                                   20


<210>  3942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3942
ccugagguca ggaguucgag                                                   20


<210>  3943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3943
ucccaccuca gccucccaaa                                                   20


<210>  3944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3944
cagcacuuug ggaggcugag                                                   20


<210>  3945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3945
gaauucagug uguacguuau                                                   20


<210>  3946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3946
aagaaauaua auacguaagc                                                   20


<210>  3947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3947
aauaagaaac acaaucaaag                                                   20


<210>  3948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3948
guccuccucc uccuccccag                                                   20


<210>  3949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3949
ccgggugcug agaacccagc                                                   20


<210>  3950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3950
gcugaucacc uacucauagg                                                   20


<210>  3951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3951
gcagaucccc gggugcugag                                                   20


<210>  3952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3952
ccuacucaua ggccaggccc                                                   20


<210>  3953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3953
aaguucuagg ugacccagug                                                   20


<210>  3954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3954
uggagguggg ggcuacagug                                                   20


<210>  3955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3955
uuaggaaggc aucuuggagg                                                   20


<210>  3956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3956
uggaggugga ggagacagcc                                                   20


<210>  3957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3957
agaagugggc ggcugucucc                                                   20


<210>  3958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3958
ccaugucgug uucaaucuuc                                                   20


<210>  3959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3959
ucuuccagau ccugacuucu                                                   20


<210>  3960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3960
ggaagaagau ugaacacgac                                                   20


<210>  3961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3961
ugacuucuag guucagcuuu                                                   20


<210>  3962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3962
aggcacaagc cagcaaagag                                                   20


<210>  3963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3963
ucacaucugu uuucuuggag                                                   20


<210>  3964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3964
guuuucuugg aguuaaucgu                                                   20


<210>  3965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3965
uuaccucuau aucgcuugcu                                                   20


<210>  3966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3966
cuugcuuauu auucuuuggc                                                   20


<210>  3967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3967
guuuuucccc agugugguca                                                   20


<210>  3968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3968
aacuugaguu auccagcucu                                                   20


<210>  3969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3969
agcucucugc cccagucugg                                                   20


<210>  3970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3970
accugcccag acuggggcag                                                   20


<210>  3971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3971
ucaggucugu aguacacuug                                                   20


<210>  3972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3972
uaggacuucu cuuugccauu                                                   20


<210>  3973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3973
aacgggagaa cugcaaagga                                                   20


<210>  3974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3974
aggaacuggg cauccaacgg                                                   20


<210>  3975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3975
ucuaguagcu uccugagaga                                                   20


<210>  3976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3976
ucucucagga agcuacuaga                                                   20


<210>  3977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3977
uuuucccuca gaaaugcaaa                                                   20


<210>  3978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3978
ccaacgugac ccgauuccuu                                                   20


<210>  3979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3979
ggucacguug gagauuuuaa                                                   20


<210>  3980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3980
cuucaguucu gggaaaauuu                                                   20


<210>  3981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3981
aacuaaccaa uuucaggaga                                                   20


<210>  3982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3982
aggaggacca acauccaacu                                                   20


<210>  3983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3983
uaccuuuuuc uuuucuuuuu                                                   20


<210>  3984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3984
aaaaaguacc agaaaaagaa                                                   20


<210>  3985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3985
aucucaaacu cuucuauuca                                                   20


<210>  3986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3986
caaacucuuc uauucauugu                                                   20


<210>  3987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3987
agagacaaag aaaagaaaga                                                   20


<210>  3988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3988
caccacugca ccacaaccug                                                   20


<210>  3989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3989
uagcucacug cagccucaaa                                                   20


<210>  3990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3990
caaaaaaaaa aaaaaaaaag                                                   20


<210>  3991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3991
caccaccgca cucuagccug                                                   20


<210>  3992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3992
cagcuacuug agaggcugag                                                   20


<210>  3993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3993
ccugagguca ggcguucgag                                                   20


<210>  3994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3994
gccugccuug gccuccgaaa                                                   20


<210>  3995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3995
cggcacuuuc ggaggccaag                                                   20


<210>  3996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3996
uuagaucuuu aaauaccagu                                                   20


<210>  3997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3997
aaugaugggc ucacgccugu                                                   20


<210>  3998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3998
uuaaauacca guaucuauaa                                                   20


<210>  3999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  3999
auaagucuuu uccucuugag                                                   20


<210>  4000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4000
cuggaaggaa auuacucauu                                                   20


<210>  4001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4001
ugcaaccggg gacuggaagg                                                   20


<210>  4002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4002
cacgucuguc cucagccuau                                                   20


<210>  4003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4003
caagaggugu uuacauaggc                                                   20


<210>  4004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4004
cucucaaucu uugccggagg                                                   20


<210>  4005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4005
uugccggagg ugggggaggg                                                   20


<210>  4006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4006
aaggcagccc aggaagcagc                                                   20


<210>  4007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4007
cuccacuuuc agauguaugu                                                   20


<210>  4008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4008
gaaaguggag ggauggagag                                                   20


<210>  4009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4009
cuccuacccu ccccuguccc                                                   20


<210>  4010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4010
gucaguuaug uagcucuugu                                                   20


<210>  4011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4011
uguaaagaag uuguauaaag                                                   20


<210>  4012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4012
agcguguugg auuagaaauc                                                   20


<210>  4013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4013
aacacgcugg auugaacuug                                                   20


<210>  4014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4014
cccacccucu gguuuauucu                                                   20


<210>  4015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4015
guguuuggca gguaauuuug                                                   20


<210>  4016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4016
uuaguguauc ccuuggugaa                                                   20


<210>  4017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4017
cuuggugaau aaccacaaag                                                   20


<210>  4018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4018
auggucuaug uacacagaau                                                   20


<210>  4019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4019
uguguauuag uauuccugua                                                   20


<210>  4020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4020
cuacaaugga augcuaugaa                                                   20


<210>  4021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4021
cuggguuguu ucuaguucuu                                                   20


<210>  4022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4022
ugcacagcua gagguggagu                                                   20


<210>  4023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4023
cccaacaacu ccaccucuag                                                   20


<210>  4024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4024
cagcugcagu agaaacugcc                                                   20


<210>  4025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4025
ccauacacag uggcaaaagg                                                   20


<210>  4026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4026
gcaauuccaa gugcuagcga                                                   20


<210>  4027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4027
ggaaggcuaa gaguaaaagc                                                   20


<210>  4028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4028
cauuaugauu uuaauuucca                                                   20


<210>  4029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4029
uaaugugauu ccagaaaaca                                                   20


<210>  4030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4030
uuaaacuuca gagccaaggg                                                   20


<210>  4031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4031
cuucccuuuu gaaguacucu                                                   20


<210>  4032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4032
auucuaaaau acaguaugcc                                                   20


<210>  4033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4033
cuucuccaag ccagcuaaca                                                   20


<210>  4034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4034
caagaauccc uucuccaagc                                                   20


<210>  4035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4035
cuacaauccc aagaaucccu                                                   20


<210>  4036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4036
uaauaaugag uagcucucau                                                   20


<210>  4037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4037
uuguaugagu ccaaauagac                                                   20


<210>  4038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4038
cggcucacug cagccuccac                                                   20


<210>  4039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4039
cuugaaccug ggagguggag                                                   20


<210>  4040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4040
cuugagguca ggaguuugag                                                   20


<210>  4041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4041
gccuucuuca gccucccaaa                                                   20


<210>  4042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4042
cagcacuuug ggaggcugaa                                                   20


<210>  4043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4043
uaaaaaacua cuuuggccaa                                                   20


<210>  4044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4044
uuucuugcag cuaaaaaagu                                                   20


<210>  4045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4045
cugacaaacu uuuuuagcug                                                   20


<210>  4046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4046
ucucugacaa acuuuuuuag                                                   20


<210>  4047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4047
ugugccuaac aguguccaga                                                   20


<210>  4048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4048
ggggucucac agccuuuaga                                                   20


<210>  4049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4049
cuguucaggg cucucagcuc                                                   20


<210>  4050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4050
auagaaacaa ugcuaaugac                                                   20


<210>  4051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4051
cuuaugggaa acgaggggau                                                   20


<210>  4052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4052
ccucguuucc cauaagggau                                                   20


<210>  4053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4053
gugccuuaag gacaugcucc                                                   20


<210>  4054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4054
cucaugcuau uguuuguggc                                                   20


<210>  4055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4055
cugaagcacu guaacauguu                                                   20


<210>  4056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4056
ggccauaaac uggccccaaa                                                   20


<210>  4057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4057
ccucccaggg aauuuacacg                                                   20


<210>  4058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4058
gaugccaguu acuaguuuac                                                   20


<210>  4059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4059
gauuuauaaa uaaguuucuc                                                   20


<210>  4060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4060
uuguucagca ugcacugagc                                                   20


<210>  4061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4061
agucauggcu cagagcauag                                                   20


<210>  4062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4062
auuucccauu auucaaaacu                                                   20


<210>  4063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4063
uggugacuau guuacuuaag                                                   20


<210>  4064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4064
uaaaauugaa aaggggugac                                                   20


<210>  4065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4065
agauuuaaau ggccaucauu                                                   20


<210>  4066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4066
ugauaaaaau auccuaaaau                                                   20


<210>  4067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4067
uuagaguuau agcacuuucu                                                   20


<210>  4068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4068
aaaggagaaa gugcuauaac                                                   20


<210>  4069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4069
gcaauuuaac uggacaugac                                                   20


<210>  4070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4070
gaaauaucug caauuuaacu                                                   20


<210>  4071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4071
aagauguucc aguccugaga                                                   20


<210>  4072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4072
ucgaucggaa auaucugcaa                                                   20


<210>  4073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4073
cuuagggugg ggcauuuacu                                                   20


<210>  4074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4074
acaaaugaca aaguuaagga                                                   20


<210>  4075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4075
agaauugagg ccuccaccau                                                   20


<210>  4076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4076
auguccucuc cgcaauggug                                                   20


<210>  4077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4077
uguauuacau aaaacuuaac                                                   20


<210>  4078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4078
uuuaucuacu uggacuuuug                                                   20


<210>  4079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4079
acuuggacuu uugcuuccgu                                                   20


<210>  4080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4080
agccgcuguc cgccgaaugg                                                   20


<210>  4081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4081
gcagugagca ucugccagca                                                   20


<210>  4082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4082
gccagcacuc aagaaggaca                                                   20


<210>  4083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4083
ugaguacaug cuggagacuc                                                   20


<210>  4084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4084
gguuuuauuu auuucaaagg                                                   20


<210>  4085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4085
ucugguuuua uuuauuucaa                                                   20


<210>  4086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4086
cucagcuucu agaccaggcu                                                   20


<210>  4087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4087
accagugcca aauagccugg                                                   20


<210>  4088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4088
gcagggucac agagacccau                                                   20


<210>  4089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4089
cacguccaca ugcucgcuuc                                                   20


<210>  4090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4090
cuagcucagc aagguccuuu                                                   20


<210>  4091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4091
ugaacgagua cgccaugagg                                                   20


<210>  4092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4092
uguuugugcc aucuugaucu                                                   20


<210>  4093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4093
ugaucucuca ggaucucuuc                                                   20


<210>  4094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4094
agauggcaca aacaugauca                                                   20


<210>  4095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4095
cucaggaucu cuucuuuuuu                                                   20


<210>  4096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4096
ugagagauca agauggcaca                                                   20


<210>  4097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4097
cuucuuuuuu aacagauuaa                                                   20


<210>  4098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4098
guuaaaaaag aagagauccu                                                   20


<210>  4099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4099
ccaaacagug agucagaugu                                                   20


<210>  4100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4100
gacucacugu uuggagauuc                                                   20


<210>  4101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4101
uaacaucuga cucacuguuu                                                   20


<210>  4102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4102
ucgacaggaa cgaguaagcc                                                   20


<210>  4103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4103
gcagagugga guguucaucc                                                   20


<210>  4104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4104
guucuuugaa ugucagucau                                                   20


<210>  4105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4105
cccgcauuug acucacggug                                                   20


<210>  4106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4106
ugaccucugg uuuuagaaac                                                   20


<210>  4107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4107
acccaguaaa uacugauuga                                                   20


<210>  4108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4108
guauuuacug gguggaugaa                                                   20


<210>  4109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4109
cagagccuag cacacagugg                                                   20


<210>  4110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4110
ccuugaguga gcauauacca                                                   20


<210>  4111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4111
caguacauua gaauuacugc                                                   20


<210>  4112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4112
aauugcuuaa aaugaggcug                                                   20


<210>  4113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4113
uacaaaacuu agcuaaaugg                                                   20


<210>  4114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4114
uuuuaagcca cuuacaauuu                                                   20


<210>  4115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4115
ugaauugaag auaaugcuaa                                                   20


<210>  4116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4116
ucaauucaug auucuauuaa                                                   20


<210>  4117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4117
acacgcagca cuuacauggc                                                   20


<210>  4118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4118
caugagacuc ugcuuuuauu                                                   20


<210>  4119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4119
uuaccuugcc uuguuuuuuu                                                   20


<210>  4120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4120
acucaugacc aguuauauuu                                                   20


<210>  4121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4121
uacuucuccc uuuuuuuauu                                                   20


<210>  4122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4122
ucuuauuuca ucuauaagua                                                   20


<210>  4123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4123
auaaguauuu caguaucucu                                                   20


<210>  4124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4124
cuauagauga ggacucuucu                                                   20


<210>  4125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4125
auagagauac ugaaauacuu                                                   20


<210>  4126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4126
uuuuaaaaau aaaguuuuaa                                                   20


<210>  4127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4127
gaccaucauu uuaaaaauaa                                                   20


<210>  4128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4128
cagaacuuug ggaggccaag                                                   20


<210>  4129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4129
gcccagcuug gccucccaaa                                                   20


<210>  4130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4130
cuugaaccug ggaguuugag                                                   20


<210>  4131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4131
gccaagugug gugaugcaug                                                   20


<210>  4132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4132
ccacacuugg cugauuuuuu                                                   20


<210>  4133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4133
cagccuccca aguagcuggg                                                   20


<210>  4134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4134
uccaggcuca ugugacccuc                                                   20


<210>  4135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4135
aggcugcagu gauccaugau                                                   20


<210>  4136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4136
cugcagccuu gaucuuccag                                                   20


<210>  4137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4137
augauuguac cacugcacuc                                                   20


<210>  4138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4138
uggaucacug cagccuugau                                                   20


<210>  4139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4139
ugggugaugg agcaagauuc                                                   20


<210>  4140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4140
cccaggaugg agugcagugg                                                   20


<210>  4141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4141
ugcuccauca cccaggaugg                                                   20


<210>  4142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4142
aauacccacc aacucauuau                                                   20


<210>  4143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4143
auuuuucucu cuacucuuuu                                                   20


<210>  4144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4144
gcaucuaaau aaaauugguc                                                   20


<210>  4145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4145
aaauaaaauu ggucgauaag                                                   20


<210>  4146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4146
accaauuuua uuuagaugcu                                                   20


<210>  4147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4147
uuaucgacca auuuuauuua                                                   20


<210>  4148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4148
cuuugaugaa cugguucccc                                                   20


<210>  4149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4149
aagagauuua caauccuuau                                                   20


<210>  4150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4150
caguuuuuuu cccuuagagu                                                   20


<210>  4151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4151
gguuucucaa uaaaugaacu                                                   20


<210>  4152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4152
gaccacagga aaacuuagaa                                                   20


<210>  4153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4153
ccacugugua aauuaacacc                                                   20


<210>  4154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4154
auaauuggag gaaaagccuu                                                   20


<210>  4155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4155
gacaaggcuu uuccuccaau                                                   20


<210>  4156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4156
gaguccagua uuucuuauau                                                   20


<210>  4157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4157
uaaaauauua uauaagaaau                                                   20


<210>  4158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4158
guuaaaaaaa auugagcaua                                                   20


<210>  4159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4159
agcagccuuc uuaaaagcau                                                   20


<210>  4160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4160
uaaaaguuua gagaucauug                                                   20


<210>  4161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4161
cuaaacuuuu augaucaagc                                                   20


<210>  4162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4162
uuggucugau gggaaaagca                                                   20


<210>  4163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4163
gaccaaugau cucuaaacuu                                                   20


<210>  4164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4164
gacccggcac agaguuggga                                                   20


<210>  4165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4165
augagaaagc cugcaggccu                                                   20


<210>  4166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4166
guucacaaau guuagaaacc                                                   20


<210>  4167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4167
aaacuguguu aaauugggau                                                   20


<210>  4168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4168
caauuuaaca caguuucgau                                                   20


<210>  4169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4169
uggaaggaca gggauagagg                                                   20


<210>  4170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4170
cuguccuucc aggauuacug                                                   20


<210>  4171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4171
auacccuuuu uuccccuuca                                                   20


<210>  4172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4172
gcaauuaagu cucacaucca                                                   20


<210>  4173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4173
uuuauuuacu uuggagaaag                                                   20


<210>  4174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4174
agaguuuaga auuugccagu                                                   20


<210>  4175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4175
uaucuagagu uuagaauuug                                                   20


<210>  4176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4176
cuauaacaua ucuuacucca                                                   20


<210>  4177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4177
uacuccaucu ucuuuugacu                                                   20


<210>  4178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4178
ucuuuugacu aaaaacuguu                                                   20


<210>  4179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4179
uaggccuggc caaacuauua                                                   20


<210>  4180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4180
auauuuugcc cacacuugcu                                                   20


<210>  4181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4181
aaaauuauca auauuuugcc                                                   20


<210>  4182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4182
aagaagcaaa cucucucacc                                                   20


<210>  4183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4183
uagaauugcu uuuacugcau                                                   20


<210>  4184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4184
uccuagaauu gcuuuuacug                                                   20


<210>  4185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4185
acaaggaggg agaaaaaggc                                                   20


<210>  4186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4186
auaggagggu cagcaagauu                                                   20


<210>  4187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4187
ugcugacccu ccuauggaug                                                   20


<210>  4188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4188
caaauuuccu uuauaaaucu                                                   20


<210>  4189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4189
aaguaugaag caaaauaagg                                                   20


<210>  4190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4190
auuacuugcu uaaaauuuau                                                   20


<210>  4191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4191
uucuuucuuu cugagucuag                                                   20


<210>  4192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4192
cguguucaua aauguuauuc                                                   20


<210>  4193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4193
uacacaucac guguucauaa                                                   20


<210>  4194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4194
ccauaguaug aaagcagugc                                                   20


<210>  4195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4195
gcccccuccu aaauucuguu                                                   20


<210>  4196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4196
gcacccacau uuccuucacc                                                   20


<210>  4197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4197
ccuggcuccu cucaauguaa                                                   20


<210>  4198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4198
auuuugaaca aagaaucucc                                                   20


<210>  4199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4199
gcuuauacuu ugacuucuua                                                   20


<210>  4200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4200
ggccccuuac acaaaacauu                                                   20


<210>  4201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4201
caagucugug gcagcuacuc                                                   20


<210>  4202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4202
caggucagca aaccacagug                                                   20


<210>  4203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4203
gaagagcuaa aagugagacu                                                   20


<210>  4204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4204
gacaguguag aagaguauaa                                                   20


<210>  4205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4205
uuaauauuau aaaauacaug                                                   20


<210>  4206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4206
gaaguucaaa uuucacuggu                                                   20


<210>  4207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4207
ugugggacau acuuacacua                                                   20


<210>  4208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4208
ggcaacugua auuaaaggga                                                   20


<210>  4209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4209
cauuauauga acauaaugaa                                                   20


<210>  4210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4210
gacaggaggc ggugcucagg                                                   20


<210>  4211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4211
guggcagcau uagauuccca                                                   20


<210>  4212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4212
aaugcugcca cugaucugac                                                   20


<210>  4213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4213
aaugccugau gaucugaggu                                                   20


<210>  4214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4214
ggcauuagau ucucauaagg                                                   20


<210>  4215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4215
ucaggcauua gauucucaua                                                   20


<210>  4216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4216
gagguggaac agucucgucu                                                   20


<210>  4217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4217
ccuggcccug uggaaaaauu                                                   20


<210>  4218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4218
cagugcuacc caaccuuucu                                                   20


<210>  4219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4219
aaaaacacua uuaugagugc                                                   20


<210>  4220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4220
cuauuuccca aaacugguga                                                   20


<210>  4221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4221
ucauucucau gcugcuccuc                                                   20


<210>  4222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4222
ugggaauuua gaaaacaaca                                                   20


<210>  4223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4223
uuagcuucca uguuguuuuc                                                   20


<210>  4224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4224
cauuggugga agugauaggg                                                   20


<210>  4225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4225
cuuccaccaa ugugaucauu                                                   20


<210>  4226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4226
uaagcuucac uuuuuuguug                                                   20


<210>  4227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4227
uacacagcac caagaccaca                                                   20


<210>  4228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4228
auagagugua acuaguauua                                                   20


<210>  4229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4229
uccuugccaa aacuuauaau                                                   20


<210>  4230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4230
uuauuuuaua aauaggggag                                                   20


<210>  4231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4231
uuccaaagug cugaaauuac                                                   20


<210>  4232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4232
cuucagccca ggaguuugag                                                   20


<210>  4233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4233
uaccaccuca gccuccaaag                                                   20


<210>  4234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4234
ugauggcagc ugcacugagc                                                   20


<210>  4235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4235
agauucacug cagccucaac                                                   20


<210>  4236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4236
ugcucuguca ccaggcucag                                                   20


<210>  4237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4237
ggaggagggg cuuuaaaugu                                                   20


<210>  4238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4238
uggaacuauu uucccuacug                                                   20


<210>  4239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4239
ucauguuaau uugccagaaa                                                   20


<210>  4240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4240
ucaagucguc agagggaucu                                                   20


<210>  4241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4241
cucugacgac uugaagaugc                                                   20


<210>  4242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4242
gagaguuccu uccuggccug                                                   20


<210>  4243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4243
gucugucccc agcucugcgu                                                   20


<210>  4244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4244
agcucccaaa ggcagcucuc                                                   20


<210>  4245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4245
cagccucuac cacugggucu                                                   20


<210>  4246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4246
auagccugcu aggcaccaga                                                   20


<210>  4247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4247
gacugaaguc uuacugcugc                                                   20


<210>  4248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4248
gccuuguuuc cuguccuuua                                                   20


<210>  4249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4249
cuaaugaaaa guuauacuug                                                   20


<210>  4250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4250
gagauuucua auacuuuuaa                                                   20


<210>  4251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4251
cagauuauuu agcugacuaa                                                   20


<210>  4252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4252
uagcuuuuuu gauuucuuag                                                   20


<210>  4253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4253
aaaaagcuaa gauaaauugc                                                   20


<210>  4254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4254
uuagaacuau auauuugaau                                                   20


<210>  4255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4255
caguucaaca uuuuaauuuc                                                   20


<210>  4256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4256
agcuguuuga agauuuucac                                                   20


<210>  4257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4257
ucaaacagcu ugauucaacu                                                   20


<210>  4258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4258
agaagaaaug ugaaaaucuu                                                   20


<210>  4259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4259
gcuuguuacu uuaucuguca                                                   20


<210>  4260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4260
gucacuuucu gugauuugca                                                   20


<210>  4261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4261
cagaaaguga cagauaaagu                                                   20


<210>  4262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4262
ccuuuuuguu uucuugaaag                                                   20


<210>  4263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4263
gagucuugug uugaaucuua                                                   20


<210>  4264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4264
uacugauuuu cuuguauuuc                                                   20


<210>  4265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4265
guaagauuca acacaagacu                                                   20


<210>  4266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4266
uguauuucuu guaauacugu                                                   20


<210>  4267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4267
cuucucagau gagugauuau                                                   20


<210>  4268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4268
gagaagagau auacacagag                                                   20


<210>  4269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4269
cucaucugag aagagauaua                                                   20


<210>  4270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4270
gauaaccagg ccugaauagu                                                   20


<210>  4271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4271
gauuccagca acauucacac                                                   20


<210>  4272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4272
gaauugcuuu gucauaaauu                                                   20


<210>  4273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4273
uaaauuucua auguucgggg                                                   20


<210>  4274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4274
uagcuuuaug ggccauaugg                                                   20


<210>  4275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4275
ucuugccuca gcccccugag                                                   20


<210>  4276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4276
uuuuucagcc auauuuaacu                                                   20


<210>  4277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4277
gaauguucug auaaaacuua                                                   20


<210>  4278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4278
gaacauucug auauguacaa                                                   20


<210>  4279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4279
caaacacuuu aauaaaaguu                                                   20


<210>  4280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4280
gcuaguuuug guacacauua                                                   20


<210>  4281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4281
uuugcaaugc caguuauuuu                                                   20


<210>  4282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4282
uaaaagacug auccuuuuuu                                                   20


<210>  4283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4283
gucuuuuaag auuucaaaau                                                   20


<210>  4284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4284
uuuuuugugu caugauuuga                                                   20


<210>  4285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4285
ugacacaaaa aaggaucagu                                                   20


<210>  4286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4286
cauuuaauac ugcaaauaau                                                   20


<210>  4287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4287
uaacaggaau agcauucuag                                                   20


<210>  4288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4288
auaauauuug cgucaucaua                                                   20


<210>  4289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4289
uaguaugaga uacuuaauca                                                   20


<210>  4290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4290
cauacuauga ugacgcaaau                                                   20


<210>  4291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4291
aguuugagau uuuagugaaa                                                   20


<210>  4292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4292
caaacuugau uaaguaucuc                                                   20


<210>  4293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4293
uuuuggcuuc uaaacaaugu                                                   20


<210>  4294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4294
cuccuaauuc aagaauauag                                                   20


<210>  4295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4295
ucguucucac cgccacugga                                                   20


<210>  4296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4296
gucaucuucg uucucaccgc                                                   20


<210>  4297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4297
gagcaaugug aaucagucau                                                   20


<210>  4298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4298
ucuucuggcu gggacauggg                                                   20


<210>  4299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4299
caugucccag ccagaagagg                                                   20


<210>  4300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4300
ugucucuuuu aagccuuuuu                                                   20


<210>  4301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4301
uuuuuaagug aaaucugccc                                                   20


<210>  4302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4302
gcccaaauua uaagacagau                                                   20


<210>  4303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4303
gucuuauaau uugggcagau                                                   20


<210>  4304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4304
aacacaacuc uaccuucauc                                                   20


<210>  4305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4305
uauauccaac acaacucuac                                                   20


<210>  4306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4306
gugguuugca aauauguucc                                                   20


<210>  4307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4307
uccaaaucag ugguuugcaa                                                   20


<210>  4308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4308
cuaucuucca aaucaguggu                                                   20


<210>  4309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4309
uaacaaaagc caucucuauc                                                   20


<210>  4310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4310
gaauucaccu uuuuggcauu                                                   20


<210>  4311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4311
aauaaaaugc caaaaaggug                                                   20


<210>  4312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4312
acuaaauaau aggaaacuuu                                                   20


<210>  4313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4313
acauggaauu aacacagcaa                                                   20


<210>  4314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4314
cacaucauug uaaguuuaug                                                   20


<210>  4315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4315
uuguaaguuu auggaaguua                                                   20


<210>  4316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4316
uacuucugac uuuuucuuug                                                   20


<210>  4317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4317
aaauaauuau ugggaauuuc                                                   20


<210>  4318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4318
caugugagug ucauuaaaug                                                   20


<210>  4319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4319
uuguggcuac aucacaugug                                                   20


<210>  4320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4320
uauuaagacu guugguuuca                                                   20


<210>  4321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4321
ucagaauuac auuaaugaga                                                   20


<210>  4322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4322
uuccagauca uauaaugcuu                                                   20


<210>  4323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4323
ggaaggauga aauaauauuu                                                   20


<210>  4324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4324
uauaaugcuu aaguucugau                                                   20


<210>  4325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4325
gaacuuaagc auuauaugau                                                   20


<210>  4326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4326
uaaagucuag aaaauuaaaa                                                   20


<210>  4327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4327
uuuaauuuuc uagacuuuau                                                   20


<210>  4328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4328
aaugcuauug gccuuugaaa                                                   20


<210>  4329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4329
uuacaguuau aacuuaccau                                                   20


<210>  4330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4330
auauuacuac uuaaacuuaa                                                   20


<210>  4331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4331
aaaucaauaa auauuaauua                                                   20


<210>  4332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4332
auaaauauua auuauuaaaa                                                   20


<210>  4333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4333
uugcuuuuaa cuuuuuccau                                                   20


<210>  4334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4334
cuacauucuu uguguuuaau                                                   20


<210>  4335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4335
uauauaagua uuuuuauacc                                                   20


<210>  4336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4336
ucauauauaa guauuuuuau                                                   20


<210>  4337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4337
uccaaggcuu cuucuucucc                                                   20


<210>  4338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4338
agaucggaug ucagcagcuc                                                   20


<210>  4339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4339
cgauucagag ucauccucca                                                   20


<210>  4340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4340
gaugucagca gcucugccuu                                                   20


<210>  4341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4341
gaucucgauu cagagucauc                                                   20


<210>  4342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4342
uauauuuguu guuuuccaug                                                   20


<210>  4343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4343
ccuacucaca aagcccuaug                                                   20


<210>  4344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4344
caugaguugg auggguuaug                                                   20


<210>  4345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4345
aacucaugag auguuucgac                                                   20


<210>  4346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4346
cauuucccaa cccccagcau                                                   20


<210>  4347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4347
cauaauuuuu caucccauuu                                                   20


<210>  4348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4348
auaggcaauu uuucauccca                                                   20


<210>  4349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4349
gccuuuguuu acagauaguu                                                   20


<210>  4350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4350
guaaacaaag gcagauucuu                                                   20


<210>  4351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4351
uuuuucuuuu uugagauaga                                                   20


<210>  4352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4352
caaaaaagaa aaaagauaac                                                   20


<210>  4353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4353
gcacugggug acagugugag                                                   20


<210>  4354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4354
cuggaaccca gaaggcggag                                                   20


<210>  4355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4355
cuugagguca ggaguucaag                                                   20


<210>  4356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4356
gccugccuca gccucccaca                                                   20


<210>  4357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4357
cggcacugug ggaggcugag                                                   20


<210>  4358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4358
guaacuggcc gggcacagug                                                   20


<210>  4359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4359
aaugaaauuc ucuguguacu                                                   20


<210>  4360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4360
uuuauaaagu acacagagaa                                                   20


<210>  4361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4361
ucaucuuuua uaaaguacac                                                   20


<210>  4362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4362
aguuauuagu accuucaguu                                                   20


<210>  4363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4363
uaucuaaaag aauauuuuag                                                   20


<210>  4364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4364
aaaagaauau uuuagcuaua                                                   20


<210>  4365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4365
gaauaauucu aguaguaauu                                                   20


<210>  4366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4366
auuuuuauuu uguaaauaaa                                                   20


<210>  4367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4367
aaaaaaaauc uauuuuuauu                                                   20


<210>  4368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4368
cagcaauccg gauacuauaa                                                   20


<210>  4369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4369
ggauacuaua aagcucacau                                                   20


<210>  4370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4370
ggauugcugu gauguuuuau                                                   20


<210>  4371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4371
uccaggagaa uaggacugga                                                   20


<210>  4372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4372
cgacuccagu ccuauucucc                                                   20


<210>  4373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4373
ugaauguggc uuggaagaag                                                   20


<210>  4374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4374
cucuggggug ggcuugccuu                                                   20


<210>  4375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4375
ccuucugaua agccuuauuu                                                   20


<210>  4376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4376
gaaggugaua uucucaaaug                                                   20


<210>  4377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4377
cucacacugc cucccacuac                                                   20


<210>  4378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4378
uucaagcauc ucucacacug                                                   20


<210>  4379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4379
ucaggaugcu gugcagcuga                                                   20


<210>  4380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4380
ugaagaugcu gaaaugcagg                                                   20


<210>  4381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4381
aauguuucag cugcacagca                                                   20


<210>  4382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4382
caggcuugca aaauaacgaa                                                   20


<210>  4383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4383
uucacugagg cugaagacag                                                   20


<210>  4384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4384
cauccuucac ugaggcugaa                                                   20


<210>  4385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4385
guggagagcu ggcugcuucu                                                   20


<210>  4386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4386
ucacagaaca gccacgguca                                                   20


<210>  4387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4387
cagaacagcc acggucacag                                                   20


<210>  4388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4388
acugaguccg ccugcagugu                                                   20


<210>  4389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4389
ggccagcugu gacuugacaa                                                   20


<210>  4390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4390
guggcagagc uugucaaguc                                                   20


<210>  4391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4391
ccaucagugg cagagcuugu                                                   20


<210>  4392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4392
uccucauccc caucaguggc                                                   20


<210>  4393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4393
ugagccacag cuccagccag                                                   20


<210>  4394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4394
gacccugcca uggaccugaa                                                   20


<210>  4395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4395
uucaggucca uggcaggguc                                                   20


<210>  4396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4396
gcgacagcuc ccagaccacc                                                   20


<210>  4397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4397
ggcccuucgg ugguggucug                                                   20


<210>  4398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4398
uuuuuuuuau uuuuuauuug                                                   20


<210>  4399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4399
cagcacuuug ggagacugag                                                   20


<210>  4400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4400
gccugccuca gucucccaaa                                                   20


<210>  4401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4401
cuugagguca ggaguucgag                                                   20


<210>  4402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4402
cggcucauug caaccucugc                                                   20


<210>  4403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4403
ugacacugca cuccagcccg                                                   20


<210>  4404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4404
cucgagccug ggaggcagaa                                                   20


<210>  4405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4405
caccuacuca ggaggcugag                                                   20


<210>  4406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4406
aaggucagga guuugagacc                                                   20


<210>  4407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4407
ucuaagguca ggaguuugag                                                   20


<210>  4408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4408
acccaccuug gccuccuaaa                                                   20


<210>  4409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4409
caauacuuua ggaggccaag                                                   20


<210>  4410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4410
uuugaguucu ucccuggaga                                                   20


<210>  4411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4411
aauaccccua uugacagcgc                                                   20


<210>  4412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4412
aagcugcgcu gucaauaggg                                                   20


<210>  4413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4413
uuaauggaga gcuugaccuc                                                   20


<210>  4414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4414
gauaccuuca cugaaggaaa                                                   20


<210>  4415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4415
gaugagguca agcucuccau                                                   20


<210>  4416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4416
acuauuccaa uuuuuuaccu                                                   20


<210>  4417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4417
uuaaggagcc uauuauaaac                                                   20


<210>  4418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4418
guuuauaaua ggcuccuuaa                                                   20


<210>  4419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4419
guggucuuaa ugaaauguga                                                   20


<210>  4420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4420
cauuucauua agaccacaga                                                   20


<210>  4421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4421
aaugggaaau guuguaaaag                                                   20


<210>  4422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4422
cuaaguuagu ggacaaaaaa                                                   20


<210>  4423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4423
augaggguuu uuuguccacu                                                   20


<210>  4424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4424
uugcuaccac ccaucucugu                                                   20


<210>  4425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4425
cuguaaccuu uugaucaugu                                                   20


<210>  4426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4426
aaagguuaca gagaugggug                                                   20


<210>  4427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4427
uguaacacug aagcucuguu                                                   20


<210>  4428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4428
ugguugccag ggacuuggcg                                                   20


<210>  4429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4429
auacaaugga auaguauuug                                                   20


<210>  4430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4430
ugcuguuaug aacgugggug                                                   20


<210>  4431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4431
guacacccac guucauaaca                                                   20


<210>  4432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4432
uugaguguuu uacuuaauag                                                   20


<210>  4433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4433
ugugaugugg aaucaugccc                                                   20


<210>  4434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4434
caagauguuu cauguccacu                                                   20


<210>  4435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4435
ugccccaagc ugauggcuaa                                                   20


<210>  4436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4436
gcuuggggca ugauuccaca                                                   20


<210>  4437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4437
acuaaauuua ggguauggua                                                   20


<210>  4438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4438
ccuaaauugc aaagacuaaa                                                   20


<210>  4439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4439
cucauuccca cuacauuaug                                                   20


<210>  4440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4440
guaagcucuu agcaguuucc                                                   20


<210>  4441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4441
gucauuuauu ucaaggcaca                                                   20


<210>  4442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4442
ccaagagaca agcccuccaa                                                   20


<210>  4443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4443
cacuucaaaa uucucacagc                                                   20


<210>  4444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4444
gcaggcccaa auacugguug                                                   20


<210>  4445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4445
uggggcuguc caaucugcag                                                   20


<210>  4446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4446
ucauccuggg gcuguccaau                                                   20


<210>  4447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4447
ggaagaauac cuguggcuuc                                                   20


<210>  4448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4448
ccuguagucc acauacccau                                                   20


<210>  4449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4449
uaauuauauc uuugcuucca                                                   20


<210>  4450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4450
uugcuuccaa gaagaagucc                                                   20


<210>  4451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4451
aaggacuucu ucuuggaagc                                                   20


<210>  4452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4452
gcuauucaga acucagaaaa                                                   20


<210>  4453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4453
uacuuuuucu ugaucuaaau                                                   20


<210>  4454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4454
agaaaaagua ugauuauucc                                                   20


<210>  4455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4455
aaaucuuaua cuuuugaguu                                                   20


<210>  4456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4456
uauacuuuug aguuaucuua                                                   20


<210>  4457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4457
uagcauaaau guauaauugu                                                   20


<210>  4458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4458
ugauuucucu guuuuuaaag                                                   20


<210>  4459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4459
agauuaagug acaaauuucc                                                   20


<210>  4460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4460
acacugcugu cagaaggcug                                                   20


<210>  4461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4461
cucaacacaa auuuaucaac                                                   20


<210>  4462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4462
cccgguucag uagcuucauc                                                   20


<210>  4463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4463
agaaaacaag gugagggaca                                                   20


<210>  4464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4464
ucacacaagc ucagaaacac                                                   20


<210>  4465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4465
cccuggcuac ugucuacuuu                                                   20


<210>  4466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4466
cugggccuuu aaauuucccc                                                   20


<210>  4467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4467
auucuguacu gaauguuucc                                                   20


<210>  4468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4468
gacaaggaaa cauucaguac                                                   20


<210>  4469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4469
aagaaaucag acaaggaaac                                                   20


<210>  4470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4470
uucauuugau gguugcguau                                                   20


<210>  4471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4471
aaugaaugau ccaagaaauc                                                   20


<210>  4472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4472
uuuuacaugu aaauguaacu                                                   20


<210>  4473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4473
aucagaauua uagccuuugg                                                   20


<210>  4474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4474
gaauuauagc cuuuggcauc                                                   20


<210>  4475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4475
cccuaucuac caggcccacu                                                   20


<210>  4476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4476
accaggccca cuuccucuua                                                   20


<210>  4477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4477
aagaggaagu gggccuggua                                                   20


<210>  4478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4478
ccugccacag cccugugacc                                                   20


<210>  4479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4479
cuuuaucccc agcaccuggc                                                   20


<210>  4480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4480
ccagcaccug gcuuaagugc                                                   20


<210>  4481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4481
guugaaugaa cuaaugcaug                                                   20


<210>  4482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4482
aaggugacau uggacagucc                                                   20


<210>  4483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4483
guggacuguc caaugucacc                                                   20


<210>  4484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4484
ucaguggacu guccaauguc                                                   20


<210>  4485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4485
gcuucguuuu ugcuaacagg                                                   20


<210>  4486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4486
ccuuuuguac ucaccauuuu                                                   20


<210>  4487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4487
gaggaugagu uugguuuuca                                                   20


<210>  4488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4488
ucagauucua cuuccucugc                                                   20


<210>  4489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4489
uuuccucccu ccccucggcu                                                   20


<210>  4490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4490
guuguuugag gcugaaggug                                                   20


<210>  4491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4491
cccaagccac cuucagccuc                                                   20


<210>  4492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4492
cuguccggaa ccagcacugc                                                   20


<210>  4493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4493
uucuucagca aacucuauaa                                                   20


<210>  4494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4494
uauuuucuca gauuuaauca                                                   20


<210>  4495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4495
gagaaaauaa gaugugaacu                                                   20


<210>  4496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4496
uuauuguaaa aacuauuuca                                                   20


<210>  4497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4497
caaaugaacu caaaacacuu                                                   20


<210>  4498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4498
aaagggaacc caugaaacaa                                                   20


<210>  4499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4499
gauuuaaacc uaaagcacaa                                                   20


<210>  4500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4500
gauguguaua uauguuggcu                                                   20


<210>  4501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4501
cgcccaugcu uacuauggag                                                   20


<210>  4502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4502
uuuuuaagug gaaucuggaa                                                   20


<210>  4503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4503
ggaauuuuaa ucagauuuau                                                   20


<210>  4504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4504
gauuuauuau cugacaaccu                                                   20


<210>  4505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4505
gauuaaaauu ccagauucca                                                   20


<210>  4506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4506
gacaaccuag aauuauaauc                                                   20


<210>  4507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4507
agaaagucug ugguauugag                                                   20


<210>  4508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4508
uauugccaau auguccucaa                                                   20


<210>  4509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4509
cuaauucuua aauccugaaa                                                   20


<210>  4510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4510
ugaaacuuuu uuuuuuuuaa                                                   20


<210>  4511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4511
cuuaggguua uuauagugaa                                                   20


<210>  4512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4512
aaauucagaa augacuucac                                                   20


<210>  4513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4513
ucucuucaca ccucuuuuuc                                                   20


<210>  4514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4514
acuuucuaac ucgaaacaaa                                                   20


<210>  4515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4515
ccacagagga acaguauguc                                                   20


<210>  4516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4516
ugaacuacau cgaucaugga                                                   20


<210>  4517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4517
aucauggaga cccacagguu                                                   20


<210>  4518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4518
auguaguuca agaugucuga                                                   20


<210>  4519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4519
uggagaccca cagguucgag                                                   20


<210>  4520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4520
gcuccauccu cagcaggucc                                                   20


<210>  4521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4521
ucagcagguc ccgcuuccac                                                   20


<210>  4522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4522
cccacgugga agcgggaccu                                                   20


<210>  4523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4523
aaucucccac guggaagcgg                                                   20


<210>  4524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4524
aaacuuaaac cuuaguaagc                                                   20


<210>  4525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4525
ucuaaacuua aaccuuagua                                                   20


<210>  4526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4526
ucaucuaaac uuaaaccuua                                                   20


<210>  4527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4527
gccaaagaaa auguauuucc                                                   20


<210>  4528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4528
uucaguguuu uccgcagcaa                                                   20


<210>  4529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4529
ucuguggaac cauuucuuca                                                   20


<210>  4530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4530
uugcuacaau uaaaauugga                                                   20


<210>  4531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4531
aucucucagc uuuagaaaga                                                   20


<210>  4532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4532
cucagcuuua gaaagaaaac                                                   20


<210>  4533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4533
uuuaggaaga ggucuauuuc                                                   20


<210>  4534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4534
uuaaguguaa agucuguuga                                                   20


<210>  4535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4535
gaccacuuug ggaggccaag                                                   20


<210>  4536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4536
uuccaccuug gccucccaaa                                                   20


<210>  4537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4537
ccccuccacc ucagcuuccc                                                   20


<210>  4538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4538
cuggggcuca agcaaucccc                                                   20


<210>  4539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4539
aggcugcagu aaggcguggu                                                   20


<210>  4540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4540
guugaauuaa aaaaaaaaaa                                                   20


<210>  4541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4541
cuaaggcuca cuuuaacucu                                                   20


<210>  4542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4542
cuuaaagaau ugagccuauu                                                   20


<210>  4543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4543
aagcaaaaaa ccuacaauug                                                   20


<210>  4544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4544
cacaaauuug acaauuguag                                                   20


<210>  4545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4545
uguggcuagc ugggggucuu                                                   20


<210>  4546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4546
caugcauggc ugacacaaag                                                   20


<210>  4547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4547
cagacccagg gguaggaaca                                                   20


<210>  4548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4548
guuacagagg ggccugccgc                                                   20


<210>  4549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4549
auguuuguga aguugcuguu                                                   20


<210>  4550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4550
caguaaauac aagcuuaaaa                                                   20


<210>  4551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4551
auguucuuga gagguguggg                                                   20


<210>  4552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4552
ugguugcagu uaaacccaga                                                   20


<210>  4553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4553
gcugcagucc uaacucacug                                                   20


<210>  4554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4554
ucgaugugcu gacucugagg                                                   20


<210>  4555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4555
augugcugac ucugaggaac                                                   20


<210>  4556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4556
augaucagcu gcaguccuaa                                                   20


<210>  4557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4557
cugcaagggu uuccagaagc                                                   20


<210>  4558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4558
auuagauuuc augaacuaag                                                   20


<210>  4559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4559
aauggaugug acucacuuac                                                   20


<210>  4560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4560
cagaacuuuc aauugagcuu                                                   20


<210>  4561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4561
cuugaugcaa ggaaugaugu                                                   20


<210>  4562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4562
agugauccca gaacuuucaa                                                   20


<210>  4563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4563
uuccuugcau caagugaucc                                                   20


<210>  4564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4564
aguacccugu ccaucagaaa                                                   20


<210>  4565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4565
gaaauccgag ugguuuaggu                                                   20


<210>  4566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4566
gagugguuua gguagaugac                                                   20


<210>  4567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4567
accuaaacca cucggauuuc                                                   20


<210>  4568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4568
cugucaucua ccuaaaccac                                                   20


<210>  4569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4569
ugucucuaaa uaaauaauaa                                                   20


<210>  4570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4570
ugcucugucg cccaggcuug                                                   20


<210>  4571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4571
uagcucacug aagcuuugaa                                                   20


<210>  4572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4572
ggaggcugag gcaggaggac                                                   20


<210>  4573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4573
agcccaggag uuugagacca                                                   20


<210>  4574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4574
aucaagccca ggaguuugag                                                   20


<210>  4575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4575
uccaucuugg ccucccaaag                                                   20


<210>  4576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4576
uggccuccca aagugcuggg                                                   20


<210>  4577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4577
cagcacuuug ggaggccaag                                                   20


<210>  4578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4578
acucuucuac uuauauuuua                                                   20


<210>  4579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4579
agaauacuua aaugacgagg                                                   20


<210>  4580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4580
uugucuuaaa cuuuuaaaaa                                                   20


<210>  4581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4581
uggcucacug caaccacagc                                                   20


<210>  4582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4582
uuagaauguu uauaaaucug                                                   20


<210>  4583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4583
gggcuuguuc ucggcuccac                                                   20


<210>  4584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4584
guggguggag ccgagaacaa                                                   20


<210>  4585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4585
ugcugcccac ucaugcacgc                                                   20


<210>  4586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4586
aggugcccug gaaggaccuu                                                   20


<210>  4587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4587
uuuaguuacu caguaaacac                                                   20


<210>  4588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4588
uuauacaggg guaagcgguu                                                   20


<210>  4589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4589
cacaaaaaua aaccgcuuac                                                   20


<210>  4590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4590
aaaacaugac gaaugcauuu                                                   20


<210>  4591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4591
ugaaaguuau aaucuuguca                                                   20


<210>  4592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4592
ugucauaugg auuuaagucu                                                   20


<210>  4593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4593
auaugacaag auuauaacuu                                                   20


<210>  4594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4594
uaccuaaaau uuagucaaau                                                   20


<210>  4595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4595
uguauuugac uaaauuuuag                                                   20


<210>  4596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4596
uucucucuaa agcuuuuaaa                                                   20


<210>  4597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4597
auuugcuugg agaugaagac                                                   20


<210>  4598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4598
ccaagcaaau ggaugacaac                                                   20


<210>  4599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4599
cuaauuaggu auuuaccaau                                                   20


<210>  4600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4600
cuuuuccuuu uuugguugaa                                                   20


<210>  4601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4601
uuuaguacuu caaccaaaaa                                                   20


<210>  4602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4602
uuugaauucu ucccucucuu                                                   20


<210>  4603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4603
gagcucauuu cagccauucu                                                   20


<210>  4604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4604
aaaaaagucu aaaauuauaa                                                   20


<210>  4605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4605
ccuucaauuc ugcugccacc                                                   20


<210>  4606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4606
cuguuaauau uuugcuauau                                                   20


<210>  4607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4607
ggucaaaauu acaugcaauu                                                   20


<210>  4608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4608
gacaauuucc acuuaauauu                                                   20


<210>  4609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4609
caaccgcaua gcaaaacaac                                                   20


<210>  4610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4610
cggcucacug caaccucugu                                                   20


<210>  4611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4611
cuugaaccag ggagacagag                                                   20


<210>  4612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4612
cagcuacucg ggaggcugag                                                   20


<210>  4613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4613
ugaaacccug ucucuacuaa                                                   20


<210>  4614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4614
cggggucaga aguucgagac                                                   20


<210>  4615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4615
accugcauug gccucccaaa                                                   20


<210>  4616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4616
cagcacuuug ggaggccaau                                                   20


<210>  4617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4617
ucuaauagcu uuauggaggu                                                   20


<210>  4618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4618
cauuucuguc accccaaaug                                                   20


<210>  4619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4619
uugugcccau uugcuguaac                                                   20


<210>  4620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4620
auuuucuguc ccuuaagauu                                                   20


<210>  4621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4621
uaagggacag aaaauagaug                                                   20


<210>  4622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4622
cagcacuuug ggaggccgag                                                   20


<210>  4623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4623
accaaccucg gccucccaaa                                                   20


<210>  4624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4624
cuugagguca ggaguucgag                                                   20


<210>  4625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4625
gacuaauuuu uguauuuuua                                                   20


<210>  4626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4626
cagcuacucg ggaggcugag                                                   20


<210>  4627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4627
cuugaaccug ggaggcggag                                                   20


<210>  4628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4628
cugcucacug caaccuccgc                                                   20


<210>  4629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4629
cgccacugcc uuccaaccug                                                   20


<210>  4630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4630
uuguuuguuu ugagacaguc                                                   20


<210>  4631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4631
auacuaugac cccaguacua                                                   20


<210>  4632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4632
cacaauuaag uaaaagaagc                                                   20


<210>  4633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4633
guaguuuguu cauuuuuauu                                                   20


<210>  4634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4634
auccaucaga uggauauuau                                                   20


<210>  4635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4635
aucagaugga uauuauagag                                                   20


<210>  4636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4636
gauggauauu auagaguuca                                                   20


<210>  4637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4637
gauggauaga uaaaauaugg                                                   20


<210>  4638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4638
aucugaugga uagauaaaau                                                   20


<210>  4639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4639
ugcaggcaaa uguucacagu                                                   20


<210>  4640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4640
acucaagaga aaugaagaca                                                   20


<210>  4641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4641
ccuagaagug gauuuuuaaa                                                   20


<210>  4642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4642
acuucuaggu gaucuacuca                                                   20


<210>  4643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4643
cagacuucac cauguaacca                                                   20


<210>  4644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4644
cauucuggua gugggaguau                                                   20


<210>  4645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4645
ggcacaauca cauucuggua                                                   20


<210>  4646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4646
guuuuuuggg cagaaguuga                                                   20


<210>  4647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4647
acuucugccc aaaaaacuga                                                   20


<210>  4648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4648
caaaaaaaau aaauaaauaa                                                   20


<210>  4649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4649
uagaaugaga cccuaucuca                                                   20


<210>  4650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4650
caccaccaca cuccagccug                                                   20


<210>  4651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4651
cggcucacug cagucucugc                                                   20


<210>  4652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4652
cuugaaccug ggaggcagag                                                   20


<210>  4653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4653
cuaccaaaaa auacaaaaau                                                   20


<210>  4654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4654
cuugagguca ggagcuugag                                                   20


<210>  4655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4655
accugccuug gccuuccaaa                                                   20


<210>  4656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4656
cagcacuuug gaaggccaag                                                   20


<210>  4657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4657
gccgggugug guagcucacg                                                   20


<210>  4658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4658
uuguaaucaa acuacugaaa                                                   20


<210>  4659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4659
aacuacugaa aagaaaacca                                                   20


<210>  4660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4660
uuguaauuug cauuucuuug                                                   20


<210>  4661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4661
aagaaaugca aauuacaaug                                                   20


<210>  4662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4662
cugaauaggc aagucauaua                                                   20


<210>  4663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4663
uuugcagaaa augguaaagc                                                   20


<210>  4664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4664
uggcucauug caacuauugc                                                   20


<210>  4665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4665
cuugaaccca ggaggcaaua                                                   20


<210>  4666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4666
cagcuacuug ggaggcugag                                                   20


<210>  4667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4667
uuaguagaga ugggguuuug                                                   20


<210>  4668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4668
cuacuaaaga uacaaaaauu                                                   20


<210>  4669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4669
gcccggccaa cauggcaaaa                                                   20


<210>  4670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4670
ugaacuccug gccucaagcg                                                   20


<210>  4671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4671
cagcacuuug ggaggccgag                                                   20


<210>  4672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4672
ugaguagaau uuuuucuaga                                                   20


<210>  4673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4673
agucuccaug aggaaagaga                                                   20


<210>  4674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4674
ucaauuaaag ucucuuuccu                                                   20


<210>  4675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4675
uggggcuugc agaccaauau                                                   20


<210>  4676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4676
uauuggucug caagccccau                                                   20


<210>  4677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4677
acacucagua auacuuuuag                                                   20


<210>  4678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4678
gccaucaaca cucaguaaua                                                   20


<210>  4679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4679
aaacugaauu caaauggaga                                                   20


<210>  4680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4680
cagcuuaagc uuugccaucu                                                   20


<210>  4681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4681
gggaguguuu gggacaguuu                                                   20


<210>  4682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4682
acaagugcug aacagugucu                                                   20


<210>  4683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4683
gaagguuuag aaagagaacu                                                   20


<210>  4684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4684
cuuucuauuu acacuauuaa                                                   20


<210>  4685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4685
agcacuaugg ggggcugagg                                                   20


<210>  4686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4686
acccaccuca gccccccaua                                                   20


<210>  4687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4687
cgaggucagg aguucaagag                                                   20


<210>  4688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4688
ccuuggccag gcuguucuug                                                   20


<210>  4689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4689
cagcuacuca ggaggcugag                                                   20


<210>  4690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4690
cuugaaccug gacggcagag                                                   20


<210>  4691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4691
uggcucacug caaccucugc                                                   20


<210>  4692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4692
cagggucacu cucaugcacc                                                   20


<210>  4693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4693
gcagggagga ggguggucua                                                   20


<210>  4694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4694
caggugaguu ucaucuacuu                                                   20


<210>  4695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4695
acuuucuuaa gcaaauuaac                                                   20


<210>  4696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4696
gcuuguccuu ggucacauuu                                                   20


<210>  4697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4697
aguaguggcc guggcaagag                                                   20


<210>  4698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4698
cuugccacgg ccacuacugg                                                   20


<210>  4699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4699
aagcaguguu uaccugaaac                                                   20


<210>  4700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4700
cauuucuccg ucagcacaau                                                   20


<210>  4701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4701
ucacauuguc gggaaaaugc                                                   20


<210>  4702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4702
ggaaagggca uuuucccgac                                                   20


<210>  4703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4703
ugagcugaag cuuuuuucua                                                   20


<210>  4704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4704
aaggacugac cuacacucaa                                                   20


<210>  4705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4705
uaucaaagga cugaccuaca                                                   20


<210>  4706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4706
uuuugaggau ugaccacacc                                                   20


<210>  4707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4707
ucaaaaugau aauauccuau                                                   20


<210>  4708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4708
cucagcugug acacuguaaa                                                   20


<210>  4709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4709
cuuaauaguu uauuacauuc                                                   20


<210>  4710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4710
guuaaaacau uuucacuuua                                                   20


<210>  4711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4711
ucuuuaaagg uaacacaacu                                                   20


<210>  4712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4712
ugccuguuga uuuuuuggug                                                   20


<210>  4713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4713
acaggcauga uagaauacaa                                                   20


<210>  4714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4714
acuaguucag ugauuugcga                                                   20


<210>  4715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4715
cugaacuagu ggauaacccu                                                   20


<210>  4716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4716
cgcaaaucac ugaacuagug                                                   20


<210>  4717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4717
uucacauuua uuguggagcu                                                   20


<210>  4718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4718
ugucaaaugg ccacauauau                                                   20


<210>  4719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4719
cauucuuauc ugcuucuuag                                                   20


<210>  4720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4720
gcuucuuagg ugagugggac                                                   20


<210>  4721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4721
ucagaauucu agcuugcaga                                                   20


<210>  4722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4722
ucucugcaag cuagaauucu                                                   20


<210>  4723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4723
cuucugcaau cuucucugca                                                   20


<210>  4724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4724
uauaaagcca auuuuuaaaa                                                   20


<210>  4725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4725
uuuaagcuua gaagucauuu                                                   20


<210>  4726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4726
cuugaugcuu uuuuucugaa                                                   20


<210>  4727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4727
agugaucauu uaagcuuaga                                                   20


<210>  4728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4728
aauaucaaag ucauaauucc                                                   20


<210>  4729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4729
aagucauaau uccugaauaa                                                   20


<210>  4730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4730
uaacacuuug ggaggcccag                                                   20


<210>  4731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4731
cagcuacucg ggaggcugag                                                   20


<210>  4732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4732
cucagccucc cgaguagcug                                                   20


<210>  4733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4733
cuugagcccc ggaggcagag                                                   20


<210>  4734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4734
uggcucacug caaccucugc                                                   20


<210>  4735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4735
gaggggaaau auuaaggugg                                                   20


<210>  4736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4736
ucuccaagag agaaaaugcc                                                   20


<210>  4737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4737
uaaaggagua uuuguccuga                                                   20


<210>  4738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4738
ucuuucacug cuucuacuua                                                   20


<210>  4739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4739
aauccucuuu cacugcuucu                                                   20


<210>  4740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4740
ggaauuugau aagcuuagaa                                                   20


<210>  4741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4741
aauuccugau aaucaaaucc                                                   20


<210>  4742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4742
ucugaaauga cauuaagaag                                                   20


<210>  4743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4743
auuaauaaau auucaucuuc                                                   20


<210>  4744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4744
caguuggcau cuauuaauaa                                                   20


<210>  4745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4745
uuaaaauuga uuacuaacua                                                   20


<210>  4746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4746
auuuuaauga uaucucaguu                                                   20


<210>  4747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4747
cgcaagaccc aauugaccac                                                   20


<210>  4748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4748
aucacgcaag acccaauuga                                                   20


<210>  4749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4749
uaaucuccuu aguuuuguug                                                   20


<210>  4750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4750
ccuuaguuuu guugaguguc                                                   20


<210>  4751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4751
cucacagugu cuuguccacg                                                   20


<210>  4752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4752
gauuggcuuu auucaaacca                                                   20


<210>  4753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4753
gauuuuguau cccucacagu                                                   20


<210>  4754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4754
cccauuauag uuauauacaa                                                   20


<210>  4755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4755
cccacggcac uuuuuugcau                                                   20


<210>  4756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4756
guuuaaguug aaauacaugc                                                   20


<210>  4757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4757
uuauuccaua acaauggcug                                                   20


<210>  4758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4758
aaauuuauuu ucagcccguu                                                   20


<210>  4759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4759
uuaaucuuaa acuuuuaaau                                                   20


<210>  4760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4760
uaaacuuuua aaugccauuu                                                   20


<210>  4761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4761
aauggcauuu aaaaguuuaa                                                   20


<210>  4762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4762
uuaaaaauau auguuuuaau                                                   20


<210>  4763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4763
caucaaccac cagagcacuc                                                   20


<210>  4764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4764
accaccagag cacucacagu                                                   20


<210>  4765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4765
agaaagagac uuacugugag                                                   20


<210>  4766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4766
gucuuacuga cauuguaaua                                                   20


<210>  4767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4767
uacggugagg ugcuugucuu                                                   20


<210>  4768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4768
augaggcuug cuaagaaauu                                                   20


<210>  4769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4769
cagcuuacuc caggaaugua                                                   20


<210>  4770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4770
gaaaaaacau agucauuuac                                                   20


<210>  4771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4771
cagcacuuug ggaggccaag                                                   20


<210>  4772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4772
gacuccugac cucaagugag                                                   20


<210>  4773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4773
cuacuaaaaa uacaaaaauu                                                   20


<210>  4774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4774
cagcuacuca ggaggcugag                                                   20


<210>  4775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4775
cuugaaccug ggagguagag                                                   20


<210>  4776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4776
gaaguuuaaa augucuagau                                                   20


<210>  4777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4777
agacauuuua aacuucugau                                                   20


<210>  4778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4778
ugccauugca cuccagccug                                                   20


<210>  4779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4779
cagcucacca caaccuccac                                                   20


<210>  4780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4780
cagcuacuca ggaggcugag                                                   20


<210>  4781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4781
ccugagguug ggaguuugag                                                   20


<210>  4782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4782
gcccuccucg accccccaaa                                                   20


<210>  4783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4783
cagcacuuug gggggucgag                                                   20


<210>  4784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4784
aagaauccaa gaauaauuaa                                                   20


<210>  4785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4785
aagaauaauu aaauuaugua                                                   20


<210>  4786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4786
cacuauauac uagcauaugu                                                   20


<210>  4787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4787
ccauauuguu aaaaauucuc                                                   20


<210>  4788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4788
ggauuguaau auugagugaa                                                   20


<210>  4789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4789
agauuauaca ucuccauauu                                                   20


<210>  4790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4790
gacuauaccc ccaccagguu                                                   20


<210>  4791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4791
gccaguguga gaaauguaua                                                   20


<210>  4792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4792
ccaagauaaa uuuugggauu                                                   20


<210>  4793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4793
uggugauuau cugccagugu                                                   20


<210>  4794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4794
caaaauuuau cuuggugauu                                                   20


<210>  4795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4795
acaaucccaa aauuuaucuu                                                   20


<210>  4796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4796
uccacaaucc caaaauuuau                                                   20


<210>  4797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4797
gaaaaauaua aagaagaaaa                                                   20


<210>  4798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4798
gaaaaaaaua auauacaaaa                                                   20


<210>  4799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4799
caaaaaauaa aaauaaaaag                                                   20


<210>  4800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4800
cacucuguug cccaggcuag                                                   20


<210>  4801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4801
ugccacugug cucuagccug                                                   20


<210>  4802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4802
uggcucacug cagccuccgc                                                   20


<210>  4803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4803
uuugaaccca ggaagcggag                                                   20


<210>  4804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4804
cgaggucagg aguucgagac                                                   20


<210>  4805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4805
acccaccucg gccucccaaa                                                   20


<210>  4806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4806
cagcacuuug ggaggccgag                                                   20


<210>  4807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4807
agggaagacc auacugcaga                                                   20


<210>  4808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4808
uaaacuuugc uuauuuauuu                                                   20


<210>  4809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4809
caagccuaca acagugcccg                                                   20


<210>  4810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4810
uguuuuucca ucccaagccu                                                   20


<210>  4811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4811
ucucccugac cagccugcag                                                   20


<210>  4812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4812
uuaggagcug agcuccagcu                                                   20


<210>  4813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4813
cccacccuuc cgccucucaa                                                   20


<210>  4814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4814
uuccagggug ugggcagcac                                                   20


<210>  4815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4815
caaugaagag agguuccugu                                                   20


<210>  4816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4816
gaauggcaau uauaucccaa                                                   20


<210>  4817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4817
gucccaccau gguacaacuu                                                   20


<210>  4818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4818
ugugguuauc auacacagau                                                   20


<210>  4819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4819
uacacagauc ucaguuuucu                                                   20


<210>  4820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4820
guguaugaua accacaggau                                                   20


<210>  4821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4821
caguuuucuu cucauuguuu                                                   20


<210>  4822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4822
ccuguuaccc uuuauaaaaa                                                   20


<210>  4823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4823
cacccaaaca ccacaaaggu                                                   20


<210>  4824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4824
aaacugagaa gaaagaaaca                                                   20


<210>  4825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4825
uaauaacuau guuuauguca                                                   20


<210>  4826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4826
auuuggcuuu uuggaaaaau                                                   20


<210>  4827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4827
gauggaauac uuguuucugc                                                   20


<210>  4828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4828
gauauuuuuc caaaaagcca                                                   20


<210>  4829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4829
augccuaaga acauuuggca                                                   20


<210>  4830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4830
ccauuucgua ugcuagguca                                                   20


<210>  4831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4831
ucaccauuuc guaugcuagg                                                   20


<210>  4832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4832
uuuuuaaaua aaagcuguua                                                   20


<210>  4833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4833
acuggaggaa aaucauuuuu                                                   20


<210>  4834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4834
gggaaauaau uucaagucuu                                                   20


<210>  4835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4835
auuacugaga augauuuugg                                                   20


<210>  4836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4836
uucucaguaa uugauacaca                                                   20


<210>  4837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4837
cauuugagaa guaaaccugc                                                   20


<210>  4838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4838
gcagguuuac uucucaaaug                                                   20


<210>  4839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4839
guuggucauu ugcugacaca                                                   20


<210>  4840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4840
acuucaagca aauaucaguu                                                   20


<210>  4841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4841
gcucuagaau gauugcuuuc                                                   20


<210>  4842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4842
uucuagagca gauaauguaa                                                   20


<210>  4843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4843
uaggucuggc acuagacuuc                                                   20


<210>  4844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4844
guucaaguaa acauacaguu                                                   20


<210>  4845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4845
auauuuuaaa uuguaaaaag                                                   20


<210>  4846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4846
uuuaaaucua uauuuuaaau                                                   20


<210>  4847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4847
ucguuucugc aucuguucac                                                   20


<210>  4848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4848
guucacaagg gguugauauu                                                   20


<210>  4849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4849
accccuugug aacagaugca                                                   20


<210>  4850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4850
auucuauguu cucuuaaugc                                                   20


<210>  4851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4851
ccuagaaaag acaguguaag                                                   20


<210>  4852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4852
uguaguaaaa guuauugaaa                                                   20


<210>  4853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4853
uuuaacacgc cauaucuugu                                                   20


<210>  4854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4854
ggaaaacuaa ccacgucaga                                                   20


<210>  4855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4855
aguacacuau uuuuccauag                                                   20


<210>  4856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4856
ccaguucagc agaaccauug                                                   20


<210>  4857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4857
gaaugaaagu auuggggccu                                                   20


<210>  4858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4858
acuaccugau uucauuucuc                                                   20


<210>  4859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4859
gguaguagau cugaaugaaa                                                   20


<210>  4860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4860
uuugagaaau gaaaucaggu                                                   20


<210>  4861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4861
gagcuccaua aaaaucauuu                                                   20


<210>  4862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4862
uuccuauaaa ucagagcucc                                                   20


<210>  4863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4863
acuaacaucu uuccuauaaa                                                   20


<210>  4864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4864
gaggcacuca guggaggcac                                                   20


<210>  4865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4865
caacgguaca gcucuuccua                                                   20


<210>  4866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4866
uuguggccau cccaacggua                                                   20


<210>  4867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4867
aaugggaacc aagcugacga                                                   20


<210>  4868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4868
cucagcccau caagaugcuu                                                   20


<210>  4869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4869
agaugcuuug auuuuggccg                                                   20


<210>  4870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4870
ugaugggcug agagauccaa                                                   20


<210>  4871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4871
aagcaucuug augggcugag                                                   20


<210>  4872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4872
aaguccugga gucccuguuu                                                   20


<210>  4873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4873
aaauccaagu ccuggagucc                                                   20


<210>  4874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4874
cuggcaauga ccuuauagua                                                   20


<210>  4875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4875
gaaauuugac uaaagggaca                                                   20


<210>  4876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4876
cagugcccga gggaguacug                                                   20


<210>  4877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4877
aaaacuaacu ugagaaugaa                                                   20


<210>  4878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4878
cccucuaauc uaaaacuaac                                                   20


<210>  4879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4879
cucuccuugg gcagauuuau                                                   20


<210>  4880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4880
gcccaaggag agugauuagg                                                   20


<210>  4881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4881
ccaaggugcu acacccucuc                                                   20


<210>  4882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4882
ucgccaaggu gcuacacccu                                                   20


<210>  4883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4883
uccauuauca ucgccaaggu                                                   20


<210>  4884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4884
auuucaaugg acuccgucuu                                                   20


<210>  4885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4885
ccaugaaaga auuggggccu                                                   20


<210>  4886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4886
uuuagucccu uucacgaaac                                                   20


<210>  4887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4887
uauuaaaaua cucaucuuuu                                                   20


<210>  4888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4888
uucauccaac uugaacaugg                                                   20


<210>  4889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4889
aacuugaaca ugggcuggag                                                   20


<210>  4890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4890
ccugagucuc ccuaccuucu                                                   20


<210>  4891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4891
acauuaaucu ccugagucuc                                                   20


<210>  4892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4892
ugccuuagca ucaacauuaa                                                   20


<210>  4893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4893
gugucuuccc uacaguccca                                                   20


<210>  4894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4894
cagguuucuu ugucuucaca                                                   20


<210>  4895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4895
ugggcaggug ugugguggug                                                   20


<210>  4896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4896
guguucccaa uuuccaugac                                                   20


<210>  4897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4897
guuucaguuu gaguuuggcu                                                   20


<210>  4898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4898
guugaauauc aggcacagau                                                   20


<210>  4899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4899
ggcacagaug ucuggccaac                                                   20


<210>  4900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4900
gugccugaua uucaacugau                                                   20


<210>  4901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4901
cagccagugc ucccaaaucu                                                   20


<210>  4902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4902
cugagaaguu caugggccuc                                                   20


<210>  4903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4903
ccuucagcag gugagagaag                                                   20


<210>  4904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4904
aggacguggg cacaaauguu                                                   20


<210>  4905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4905
agcacccaag ugggacauua                                                   20


<210>  4906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4906
gucccuucuu uauucucuuu                                                   20


<210>  4907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4907
gagcaauuuu guucauuuaa                                                   20


<210>  4908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4908
aaaugugacc auguggaugg                                                   20


<210>  4909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4909
acauggucac auuuugaugu                                                   20


<210>  4910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4910
acuugccuca gucucccaaa                                                   20


<210>  4911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4911
cuugaggcca agaguucgag                                                   20


<210>  4912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4912
cgaaaccccc ucucuacuaa                                                   20


<210>  4913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4913
aauuuuuugu auuuuuagua                                                   20


<210>  4914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4914
cagcacuuug ggaggccgag                                                   20


<210>  4915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4915
gcccaccucg gccucccaaa                                                   20


<210>  4916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4916
cgaggucaag agaucaagac                                                   20


<210>  4917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4917
cuugaccucg ugauccgccc                                                   20


<210>  4918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4918
agaccauccu ggcuaacaca                                                   20


<210>  4919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4919
uggcuaacac agugaaaccc                                                   20


<210>  4920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4920
gagcauggug gcgggcgccu                                                   20


<210>  4921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4921
gggaggcgga gcuugcagug                                                   20


<210>  4922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4922
cggcucacug caagcuccgc                                                   20


<210>  4923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4923
ugccacugca cuccagccug                                                   20


<210>  4924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4924
aauuuuuuuu uugagacgga                                                   20


<210>  4925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4925
cagcuacuug ggaggcugag                                                   20


<210>  4926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4926
aggcuuacug caaacuccgc                                                   20


<210>  4927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4927
ucagucacug uuaucccuaa                                                   20


<210>  4928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4928
gucacuguua ucccuaagag                                                   20


<210>  4929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4929
cuaagaggga aauaccuagc                                                   20


<210>  4930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4930
auucugagcu uucuuggcua                                                   20


<210>  4931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4931
ugguuaaugg cuacuguccu                                                   20


<210>  4932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4932
cagggacagu uuugcuuuuc                                                   20


<210>  4933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4933
acuucaaaac aaauguuaac                                                   20


<210>  4934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4934
auuguacaaa uaguuaacau                                                   20


<210>  4935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4935
uaaauccauu guacaaauag                                                   20


<210>  4936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4936
caaaaaaaaa aaaaaaaaaa                                                   20


<210>  4937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4937
caccauugca cuccagccca                                                   20


<210>  4938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4938
cagcucacug caacuucugc                                                   20


<210>  4939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4939
uuugaaccca ggaggcagaa                                                   20


<210>  4940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4940
gccucgagag gcugaggcag                                                   20


<210>  4941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4941
cagcuguaau cugccucgag                                                   20


<210>  4942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4942
cuucagguca ggaguuugag                                                   20


<210>  4943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4943
auccgcuucg gccucccaaa                                                   20


<210>  4944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4944
gcuucggccu cccaaagugu                                                   20


<210>  4945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4945
caacacuuug ggaggccgaa                                                   20


<210>  4946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4946
uaggcugggc gugguggcuc                                                   20


<210>  4947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4947
gauuacucuc ucuuugccuu                                                   20


<210>  4948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4948
gauauaaaca guaagugaac                                                   20


<210>  4949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4949
cccuacuaac uucccauucu                                                   20


<210>  4950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4950
gucuucuccc uucucugcaa                                                   20


<210>  4951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4951
cuggagaguc ccagccucag                                                   20


<210>  4952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4952
uuccuuaacc ccugcuggug                                                   20


<210>  4953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4953
gggcgggaaa cgcugcuaug                                                   20


<210>  4954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4954
ugucuuuaca ucucugggca                                                   20


<210>  4955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4955
cugggcacug cucugguccu                                                   20


<210>  4956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4956
ugcaggcugc uacccccauc                                                   20


<210>  4957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4957
ugaguguccu cuucaguugg                                                   20


<210>  4958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4958
ggguucaguu cuucagucac                                                   20


<210>  4959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4959
agacacugaa gacaggagaa                                                   20


<210>  4960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4960
gcuauaugua agugucacgg                                                   20


<210>  4961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4961
acaaaucagc uauauguaag                                                   20


<210>  4962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4962
caccgugucu gacauaucca                                                   20


<210>  4963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4963
gccccugccc cauuuacccc                                                   20


<210>  4964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4964
agcuagaaac aggucaccac                                                   20


<210>  4965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4965
caaggucagg agaucgagac                                                   20


<210>  4966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4966
ccugaccuug ugaugcacug                                                   20


<210>  4967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4967
agaccauucc ggcucacacg                                                   20


<210>  4968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4968
gccucccagg uagcugggac                                                   20


<210>  4969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4969
cggcucacug caagcuccgc                                                   20


<210>  4970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4970
gagcucuauc uccucucagg                                                   20


<210>  4971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4971
ccucucaggc cagugguggc                                                   20


<210>  4972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4972
aaugccacca cuggccugag                                                   20


<210>  4973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4973
ucacauggcc cacaggaaaa                                                   20


<210>  4974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4974
uucuuuuucu cucucucucu                                                   20


<210>  4975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4975
cccuggugcu ccuuugugua                                                   20


<210>  4976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4976
uggggguagu uucuaauggu                                                   20


<210>  4977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4977
aaucaccucc caccaggccc                                                   20


<210>  4978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4978
ccucccacca ggccccaccu                                                   20


<210>  4979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4979
ccagugucgg agguggggcc                                                   20


<210>  4980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4980
caugcugaau uguaaucucc                                                   20


<210>  4981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4981
gagcaugaac ccuauuguga                                                   20


<210>  4982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4982
cucaaaugug caguucacaa                                                   20


<210>  4983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4983
agguugcaug cuccuuauga                                                   20


<210>  4984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4984
aaugccugau gaugauuuga                                                   20


<210>  4985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4985
ggcauuagau ucucauaagg                                                   20


<210>  4986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4986
ucaggcauua gauucucaua                                                   20


<210>  4987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4987
ucaucaggca uuagauucuc                                                   20


<210>  4988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4988
cgaaaccauc ccccgccaac                                                   20


<210>  4989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4989
cccgccaacc cugguuugug                                                   20


<210>  4990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4990
gucuggacca gaaguggcag                                                   20


<210>  4991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4991
cauuuggauu acugcacuag                                                   20


<210>  4992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4992
aaaugagaua guauaucagu                                                   20


<210>  4993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4993
caaaaaaauu aaauuaaauu                                                   20


<210>  4994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4994
ugacacugca cuccaagcug                                                   20


<210>  4995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4995
uagcucacug cggccucgau                                                   20


<210>  4996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4996
aggccgcagu gagcuaugau                                                   20


<210>  4997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4997
cccaggcuca agugauccuu                                                   20


<210>  4998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4998
cuugagccug ggagaucgag                                                   20


<210>  4999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  4999
uucugccuca gccuucucag                                                   20


<210>  5000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5000
aaaaauuagc ugggcauggu                                                   20


<210>  5001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5001
cgccaaccca cuccagccug                                                   20


<210>  5002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5002
cagcucacug caacuucugc                                                   20


<210>  5003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5003
cuugaaccug ggaggcagaa                                                   20


<210>  5004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5004
caacuacucg ggaggcugag                                                   20


<210>  5005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5005
cgaggucaca aguucgagac                                                   20


<210>  5006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5006
cagcacuuug ggaggccgag                                                   20


<210>  5007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5007
caagaaugcu guuuccuggc                                                   20


<210>  5008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5008
ccagaaucag uuuuagaacc                                                   20


<210>  5009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5009
guuuuagaac ccauaaagga                                                   20


<210>  5010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5010
acaguaaugu ccagaagacg                                                   20


<210>  5011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5011
cuugaacccg ggaggcagaa                                                   20


<210>  5012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5012
cuacuaaaaa aaaaaaaaaa                                                   20


<210>  5013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5013
agaccacccu ggcuaacaug                                                   20


<210>  5014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5014
ccugacuuca ugauccgccu                                                   20


<210>  5015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5015
ugaagucagg agaucgagac                                                   20


<210>  5016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5016
gccugccucg gccucccaaa                                                   20


<210>  5017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5017
cagcacuuug ggaggccgag                                                   20


<210>  5018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5018
gggaagaaau gcagacagua                                                   20


<210>  5019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5019
ggugcaugga cuggaaggca                                                   20


<210>  5020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5020
uauuaugguu uaaggugacu                                                   20


<210>  5021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5021
uggacuuccc aaccuccaga                                                   20


<210>  5022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5022
aggacuuucg ccuugcccuc                                                   20


<210>  5023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5023
auauauaaga ggccccacag                                                   20


<210>  5024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5024
cauucaugag gggucugccc                                                   20


<210>  5025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5025
cccugguaau uaaguuucag                                                   20


<210>  5026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5026
uagaaaagug cuuguuaugg                                                   20


<210>  5027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5027
gggagugagu aaguagcaga                                                   20


<210>  5028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5028
ugccuucacu cugcuccaug                                                   20


<210>  5029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5029
uggagcagag ugaaggcaag                                                   20


<210>  5030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5030
agacucccaa ugcucuagga                                                   20


<210>  5031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5031
ccaauacaca acacaugaga                                                   20


<210>  5032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5032
ggauuuguug acuucuagcu                                                   20


<210>  5033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5033
agauguauuc auaaagccuc                                                   20


<210>  5034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5034
cugagccugu uuccucuuuu                                                   20


<210>  5035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5035
cagccuccca aagugcugga                                                   20


<210>  5036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5036
ucccaucuca gccucccaaa                                                   20


<210>  5037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5037
cuggagcuug gaguucgaga                                                   20


<210>  5038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5038
uagugugaga uccugucucc                                                   20


<210>  5039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5039
cacacuauga ugcccaggcu                                                   20


<210>  5040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5040
ugucuccuca agaaauuaaa                                                   20


<210>  5041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5041
cccagcuaau uuuuuaauuu                                                   20


<210>  5042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5042
acucuggagg cugagguggg                                                   20


<210>  5043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5043
ucccaccuca gccuccagag                                                   20


<210>  5044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5044
uauuucauug uagccucaac                                                   20


<210>  5045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5045
ugggugacga gugagacccu                                                   20


<210>  5046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5046
ucaacucauu cucugugcac                                                   20


<210>  5047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5047
uugugugggu aaaaguaaau                                                   20


<210>  5048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5048
ggguccaaga acaaaaugag                                                   20


<210>  5049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5049
cauguuuuug uuuuuuuguu                                                   20


<210>  5050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5050
gacgaaaggg gaaggagaaa                                                   20


<210>  5051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5051
guaccguuga gucccaagaa                                                   20


<210>  5052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5052
gucauguaga aacauaggau                                                   20


<210>  5053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5053
uauguuucua caugacagau                                                   20


<210>  5054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5054
guaaagugag agaaaguuuc                                                   20


<210>  5055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5055
ugaaccgcac cuggagaaac                                                   20


<210>  5056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5056
gucauuaguu ucuaauaucu                                                   20


<210>  5057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5057
cucuccuaug cuucccuggu                                                   20


<210>  5058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5058
ccugcaacca gggaagcaua                                                   20


<210>  5059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5059
ggaggccucu ccagccauca                                                   20


<210>  5060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5060
acaccacuuc ccuuacugaa                                                   20


<210>  5061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5061
auuccuaagc aucuacacca                                                   20


<210>  5062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5062
guuuuuucac ucacuacauc                                                   20


<210>  5063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5063
gaaucaguuu uuucacucac                                                   20


<210>  5064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5064
gaauuuuuga cauaucagaa                                                   20


<210>  5065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5065
ccacuuucuc ucgccuuuag                                                   20


<210>  5066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5066
gaguuggagg agcuuaaacc                                                   20


<210>  5067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5067
uagccccuuc uguucugacc                                                   20


<210>  5068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5068
auacugcucu cggugggcag                                                   20


<210>  5069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5069
gggacgccug gccaccuguc                                                   20


<210>  5070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5070
cuggccccug ggugccaaga                                                   20


<210>  5071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5071
aggcuauuua uuuauuuauu                                                   20


<210>  5072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5072
cggcucagug caagcucugc                                                   20


<210>  5073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5073
uggccaacaa ggugaaaccc                                                   20


<210>  5074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5074
agaccauccu ggccaacaag                                                   20


<210>  5075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5075
ccugaccucg ugauccgucc                                                   20


<210>  5076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5076
cgaggucagg agaucaagac                                                   20


<210>  5077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5077
guccaccuca gccucucaaa                                                   20


<210>  5078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5078
cagcacuuug agaggcugag                                                   20


<210>  5079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5079
guaauauaca acaugauguu                                                   20


<210>  5080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5080
uguuguauau uacagauaua                                                   20


<210>  5081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5081
cagcacuuug ggaggcugag                                                   20


<210>  5082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5082
gcccaccuca gccucccaaa                                                   20


<210>  5083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5083
cgaggucggg aguucaagac                                                   20


<210>  5084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5084
ugucucuacu aaaaauacca                                                   20


<210>  5085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5085
ggcaggugga gguugcagug                                                   20


<210>  5086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5086
cccaggcuag agugcagugg                                                   20


<210>  5087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5087
ccucacguau cauuguuuug                                                   20


<210>  5088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5088
uuguuuugug gugagaacac                                                   20


<210>  5089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5089
acucuuucag ugauuuucuu                                                   20


<210>  5090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5090
cugaaagagu agauuuuaag                                                   20


<210>  5091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5091
acuguauagc auggugacug                                                   20


<210>  5092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5092
cuugaacuca uuccuccugu                                                   20


<210>  5093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5093
uugaccaaca cauucaaggu                                                   20


<210>  5094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5094
caaaaaaaac cuugaaugug                                                   20


<210>  5095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5095
ugccauggua cuccagccug                                                   20


<210>  5096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5096
caucucacug caaccuccgc                                                   20


<210>  5097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5097
cacugcaacc uccgccuccc                                                   20


<210>  5098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5098
cagcuacuca ggaggcugag                                                   20


<210>  5099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5099
cuugagguca ggaguucgag                                                   20


<210>  5100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5100
gccugccuug gccugccaaa                                                   20


<210>  5101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5101
cagcacuuug gcaggccaag                                                   20


<210>  5102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5102
uuuaaaacgc uugaggccgg                                                   20


<210>  5103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5103
uuagaaaaga gcaucuuuua                                                   20


<210>  5104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5104
uccuccugua cuacagucaa                                                   20


<210>  5105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5105
guauauuacu aucaucuuuc                                                   20


<210>  5106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5106
ucuuucugau gaauuaaaua                                                   20


<210>  5107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5107
uucugaugaa uuaaauaaac                                                   20


<210>  5108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5108
gaaagaugau aguaauauac                                                   20


<210>  5109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5109
guuuaaugau aauguuugug                                                   20


<210>  5110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5110
uuaaaccgau acuaaauauu                                                   20


<210>  5111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5111
ucccuguuug auuacuuggu                                                   20


<210>  5112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5112
cuguuugauu acuuggugug                                                   20


<210>  5113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5113
aacagggaug auguaaaaau                                                   20


<210>  5114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5114
uaggcucaga gagguucugg                                                   20


<210>  5115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5115
gcugcuccua ugauucucua                                                   20


<210>  5116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5116
uaggagcagc ugauucaagg                                                   20


<210>  5117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5117
guuagagaau cauaggagca                                                   20


<210>  5118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5118
uaacaaaaca acugugcaca                                                   20


<210>  5119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5119
aaaggucaga ggaaauacuu                                                   20


<210>  5120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5120
ugauuuccag uaaucucuuu                                                   20


<210>  5121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5121
ugauuuuuua aaguauucua                                                   20


<210>  5122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5122
cuuuaaaacu uggcaaguua                                                   20


<210>  5123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5123
aaauaacuug ccaaguuuua                                                   20


<210>  5124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5124
aaaaguuuau cuuuugugug                                                   20


<210>  5125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5125
uuugugugca uauuuuuaaa                                                   20


<210>  5126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5126
gauaccucag guccuguuac                                                   20


<210>  5127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5127
gauugucuag aagcuuuaaa                                                   20


<210>  5128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5128
ucaucacugg ggaguuucua                                                   20


<210>  5129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5129
cuggggaguu ucuaucaucu                                                   20


<210>  5130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5130
ucuuccuuca uaccucaaac                                                   20


<210>  5131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5131
uccuucauac cucaaacugc                                                   20


<210>  5132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5132
ugcaguuuga gguaugaagg                                                   20


<210>  5133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5133
uuuaaaaaua uauaugcaca                                                   20


<210>  5134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5134
auuagacgua aguaugugug                                                   20


<210>  5135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5135
acuauccauu agacguaagu                                                   20


<210>  5136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5136
uaagaaaaac aucaacuauc                                                   20


<210>  5137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5137
uacaaaucau aagaaaaaca                                                   20


<210>  5138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5138
caaagggcuu auacauccua                                                   20


<210>  5139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5139
uaaacaaagc ugaaagacaa                                                   20


<210>  5140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5140
uacagguguu uuggauuuuc                                                   20


<210>  5141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5141
aaaacaccug uaugauagaa                                                   20


<210>  5142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5142
uagcugugag uacaaacaau                                                   20


<210>  5143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5143
aucuuagcug ugaguacaaa                                                   20


<210>  5144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5144
uagcucuguc acuguaauca                                                   20


<210>  5145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5145
cuccagacuc caccagggcc                                                   20


<210>  5146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5146
guguacaggc uuccuucccu                                                   20


<210>  5147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5147
gcuagggaaa guuuauguca                                                   20


<210>  5148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5148
ggugaacagu uucuuacgcu                                                   20


<210>  5149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5149
cuagacagaa aggcuggcuc                                                   20


<210>  5150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5150
gcaauuuguu agauaugaag                                                   20


<210>  5151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5151
aacaaauugc agaugaacag                                                   20


<210>  5152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5152
aucuaucugu cugcucaucu                                                   20


<210>  5153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5153
aucugucugc ucaucuauua                                                   20


<210>  5154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5154
gucugcucau cuauuagaag                                                   20


<210>  5155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5155
auuagaagca uccuuguuuu                                                   20


<210>  5156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5156
uuguuuuuuu uuuuucuuuu                                                   20


<210>  5157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5157
cuugagcccu gagacugcag                                                   20


<210>  5158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5158
ucccaccuca gcuccugagu                                                   20


<210>  5159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5159
ucccuccuug gccucccaaa                                                   20


<210>  5160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5160
cagcacuuug ggaggccaag                                                   20


<210>  5161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5161
ccucauaaau accauuaagc                                                   20


<210>  5162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5162
guuccccugu uguucuuuag                                                   20


<210>  5163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5163
agaaaauucu aaagaacaac                                                   20


<210>  5164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5164
auaaagaaga auauccagaa                                                   20


<210>  5165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5165
caaaaucaau aaagaagaau                                                   20


<210>  5166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5166
acuucuacuu guagauugau                                                   20


<210>  5167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5167
acaaguagaa guugauucua                                                   20


<210>  5168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5168
aucuacaagu agaaguugau                                                   20


<210>  5169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5169
gagguauaag uucucccuaa                                                   20


<210>  5170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5170
cacauucugg acagggugac                                                   20


<210>  5171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5171
uuuaaauuuc augugcuucu                                                   20


<210>  5172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5172
uuaaguuuuu uuuaaaaucc                                                   20


<210>  5173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5173
agaaaugugc aagagcuaug                                                   20


<210>  5174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5174
ucagguauuc cucuguuuuu                                                   20


<210>  5175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5175
uuuaucaaac guauguggcu                                                   20


<210>  5176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5176
aacguaugug gcuuauuuuc                                                   20


<210>  5177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5177
uucagaaaau aagccacaua                                                   20


<210>  5178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5178
aacauccuuc agaaaauaag                                                   20


<210>  5179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5179
uccaaaauua ucaaacaucc                                                   20


<210>  5180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5180
ucucuacggc auuuuucaac                                                   20


<210>  5181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5181
ucuugaauuu cagggcaccu                                                   20


<210>  5182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5182
ugaauuucag ggcaccuuuc                                                   20


<210>  5183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5183
guuuauuauu uuccuuccug                                                   20


<210>  5184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5184
uggacuccug uuuccuuugc                                                   20


<210>  5185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5185
ccgcggucag cuccugcugc                                                   20


<210>  5186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5186
agcaagacac gccaggcacu                                                   20


<210>  5187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5187
uugaguauug ccucugguuu                                                   20


<210>  5188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5188
gaggagugca ggaagggcca                                                   20


<210>  5189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5189
uaauucucau cucaugaccu                                                   20


<210>  5190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5190
caugaccucu uuucccuucu                                                   20


<210>  5191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5191
gaccucuccu ggacaacagg                                                   20


<210>  5192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5192
cacaugacau caccacauca                                                   20


<210>  5193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5193
ccacaucacc ucguuccuug                                                   20


<210>  5194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5194
ccucguuccu uggacccuca                                                   20


<210>  5195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5195
agcagugaca ccacugaggg                                                   20


<210>  5196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5196
aaauaccaug acuacgcuag                                                   20


<210>  5197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5197
acucacauuu ucaguuucug                                                   20


<210>  5198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5198
aagaacccuu gugaaagaga                                                   20


<210>  5199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5199
uuuagaaucu uaacacaucu                                                   20


<210>  5200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5200
uaacacaucu uacaccugau                                                   20


<210>  5201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5201
uacaccugau uuaauauuuu                                                   20


<210>  5202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5202
gguguaagau guguuaagau                                                   20


<210>  5203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5203
aaauugaacc aacccuaugu                                                   20


<210>  5204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5204
cugucaaauu cacauagggu                                                   20


<210>  5205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5205
cugggagaaa ucacugucaa                                                   20


<210>  5206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5206
uaguguauaa ggaauaggac                                                   20


<210>  5207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5207
aaaaauagaa aauacuaagu                                                   20


<210>  5208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5208
gguauguggu auaucaaaaa                                                   20


<210>  5209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5209
guaucuggua ugugguauau                                                   20


<210>  5210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5210
uaaucaguau cugguaugug                                                   20


<210>  5211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5211
gaaaggaauu ucuuuccaaa                                                   20


<210>  5212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5212
gcugcagccg ucgauguuug                                                   20


<210>  5213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5213
acggcugcag cagaugccuc                                                   20


<210>  5214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5214
cauaauguac aaccaaagac                                                   20


<210>  5215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5215
ugacagggcc aguaaccgug                                                   20


<210>  5216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5216
agcgugaccu ugggaaggug                                                   20


<210>  5217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5217
ucagaacagc acggaaaagu                                                   20


<210>  5218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5218
aaggcugagc ggagaaaccc                                                   20


<210>  5219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5219
gagaaagaac auccaaggcu                                                   20


<210>  5220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5220
agugugccag ccacaaccca                                                   20


<210>  5221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5221
aggauggagc cugguucucc                                                   20


<210>  5222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5222
uagaugaacu cagcccagaa                                                   20


<210>  5223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5223
uguauuagcu uagacccagu                                                   20


<210>  5224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5224
guggguuuca aaauguguuu                                                   20


<210>  5225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5225
gugucagaga auaugacugu                                                   20


<210>  5226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5226
cacagaaagu cagcggcaga                                                   20


<210>  5227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5227
acgagacuuu uaacucaggc                                                   20


<210>  5228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5228
uggcacgugu auaccuaugu                                                   20


<210>  5229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5229
acccaucacc uacauuaggu                                                   20


<210>  5230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5230
ccuacauuag guauuucucc                                                   20


<210>  5231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5231
cucccccagu ccccucacuc                                                   20


<210>  5232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5232
cacaccgggg cccaugggga                                                   20


<210>  5233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5233
gaaaaccaaa caccgcaugu                                                   20


<210>  5234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5234
ugugauaguu ugcugagaau                                                   20


<210>  5235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5235
caagaucaga aaaccaaaca                                                   20


<210>  5236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5236
uucucagcaa acuaucacaa                                                   20


<210>  5237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5237
uccaugugcc ugcaaaggac                                                   20


<210>  5238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5238
augugccugc aaaggacaug                                                   20


<210>  5239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5239
uuuuuuaugg cuguauagua                                                   20


<210>  5240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5240
agucuaucau ugauggacau                                                   20


<210>  5241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5241
uugauggaca uucggguugg                                                   20


<210>  5242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5242
augauagacu ggauuaagaa                                                   20


<210>  5243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5243
uagaaugauu uauaauccuu                                                   20


<210>  5244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5244
uucuacgaua aagacacaug                                                   20


<210>  5245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5245
uuuggguaua ugcccaguaa                                                   20


<210>  5246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5246
cauuacuggg cauauaccca                                                   20


<210>  5247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5247
ccagacuguc uuccacaaua                                                   20


<210>  5248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5248
guuguuucgu gacuuuuuaa                                                   20


<210>  5249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5249
uuaaaaaguc acgaaacaac                                                   20


<210>  5250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5250
ccauccuaac uggcgugaga                                                   20


<210>  5251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5251
uaacuggcgu gagaugguau                                                   20


<210>  5252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5252
cacgccaguu aggauggcga                                                   20


<210>  5253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5253
cauugugauu uugaucugca                                                   20


<210>  5254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5254
caaugagaua ccaucucacg                                                   20


<210>  5255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5255
aaaucacaau gagauaccau                                                   20


<210>  5256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5256
gcauuucucu aaugaccagu                                                   20


<210>  5257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5257
ccacugguca uuagagaaau                                                   20


<210>  5258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5258
uuuguccauu uuuugauggg                                                   20


<210>  5259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5259
aaaaauggac aaaggauaug                                                   20


<210>  5260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5260
acaaagaacu uaaacaaauu                                                   20


<210>  5261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5261
agaaucuaca aagaacuuaa                                                   20


<210>  5262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5262
uuugucagau ggguagauug                                                   20


<210>  5263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5263
gacaaaagau uaacauccag                                                   20


<210>  5264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5264
acccaucuga caaaagauua                                                   20


<210>  5265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5265
cauucuguag guugccuguu                                                   20


<210>  5266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5266
gagugaacag gcaaccuaca                                                   20


<210>  5267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5267
ucagagugaa caggcaaccu                                                   20


<210>  5268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5268
aauuaaacua aagagcuucu                                                   20


<210>  5269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5269
cguuugucaa uuuuggcuuu                                                   20


<210>  5270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5270
uagaagaaaa ccugggccau                                                   20


<210>  5271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5271
aagacuuaaa cauaagaccu                                                   20


<210>  5272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5272
aucuugaguu gauuuuugug                                                   20


<210>  5273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5273
ugaguugauu uuuguguaag                                                   20


<210>  5274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5274
acucaagaug gaucaaagac                                                   20


<210>  5275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5275
uuuccccauu gcuuaugugu                                                   20


<210>  5276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5276
uugacaaacc ugacacacau                                                   20


<210>  5277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5277
gaugauugua gauguguggu                                                   20


<210>  5278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5278
gaucuuugac aaaccugaca                                                   20


<210>  5279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5279
ucugaucuuu gacaaaccug                                                   20


<210>  5280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5280
acaaucaucu gaucuuugac                                                   20


<210>  5281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5281
guuuugguac caguaccaug                                                   20


<210>  5282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5282
cacuaccuga cuucaaacua                                                   20


<210>  5283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5283
ugggcuagaa gaacaaagcu                                                   20


<210>  5284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5284
cugacuuucu ucacagaauu                                                   20


<210>  5285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5285
agcuaucacu gacuuucuuc                                                   20


<210>  5286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5286
ccccaucaag cuaucacuga                                                   20


<210>  5287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5287
auaaauuacu uugggcagca                                                   20


<210>  5288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5288
ugaaaauggc cuugcugccc                                                   20


<210>  5289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5289
auaucgugaa aauggccuug                                                   20


<210>  5290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5290
augaacaugg aauguuuuuc                                                   20


<210>  5291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5291
cuuguaaguu gucuuccuag                                                   20


<210>  5292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5292
ugagugaacu cccauucaca                                                   20


<210>  5293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5293
caagcauucc uauacaccaa                                                   20


<210>  5294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5294
augugcaaaa aucacaagca                                                   20


<210>  5295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5295
ugagacuuug cugaaguugc                                                   20


<210>  5296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5296
gcuuaaggag auuuugagcu                                                   20


<210>  5297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5297
ccuuaagcug auuagcaacu                                                   20


<210>  5298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5298
ugucaucugc aaacagggac                                                   20


<210>  5299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5299
gcaaacaggg acaguuuuac                                                   20


<210>  5300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5300
ggcaagagaa agcaauaaag                                                   20


<210>  5301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5301
uugucuugug ccgguuuucg                                                   20


<210>  5302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5302
uacugaaugg gcaaaaacug                                                   20


<210>  5303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5303
caacauagua agagcuauuu                                                   20


<210>  5304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5304
auaccuaguu uauugagagu                                                   20


<210>  5305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5305
auggaacgua ucucaacaua                                                   20


<210>  5306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5306
guugagauaa ucauaugguu                                                   20


<210>  5307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5307
caacagaugc agaaaaggcc                                                   20


<210>  5308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5308
uaugguuuuu guuguugguu                                                   20


<210>  5309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5309
cauaaacaga accaacaaca                                                   20


<210>  5310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5310
aucacauaaa cagaaccaac                                                   20


<210>  5311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5311
auaaacguaa uccaucacau                                                   20


<210>  5312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5312
cuggaaugca aggcugguuc                                                   20


<210>  5313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5313
agucagcuuc aucccuggaa                                                   20


<210>  5314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5314
accacaauca agucagcuuc                                                   20


<210>  5315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5315
aaaagcuuau ccaccacaau                                                   20


<210>  5316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5316
agcagcacau caaaaagcuu                                                   20


<210>  5317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5317
ucaauaaaau acuggcaaac                                                   20


<210>  5318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5318
auguucauca gggauauugg                                                   20


<210>  5319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5319
augugaaaau ccucaauaaa                                                   20


<210>  5320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5320
gggauauugg ccuaaaauuc                                                   20


<210>  5321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5321
cugaugaaca ucgaugugaa                                                   20


<210>  5322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5322
ggaugaugcu ggccucauaa                                                   20


<210>  5323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5323
ugauaccaaa gccuggcaga                                                   20


<210>  5324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5324
uccugauacc aaagccuggc                                                   20


<210>  5325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5325
ucccuaacuc auuuuaugag                                                   20


<210>  5326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5326
auagaaaaag agagaauccu                                                   20


<210>  5327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5327
ccucuuugua ccucugguag                                                   20


<210>  5328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5328
auccuggacu uuuuuugguu                                                   20


<210>  5329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5329
uggacuuuuu uugguuagua                                                   20


<210>  5330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5330
gucuauucag agauucagcu                                                   20


<210>  5331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5331
cugaauagac ugauaacagg                                                   20


<210>  5332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5332
auuucuucua gauuuucuag                                                   20


<210>  5333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5333
agaagaaaug gauaaauucc                                                   20


<210>  5334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5334
cuacccaaau aaacuagaaa                                                   20


<210>  5335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5335
gagaauacua uaaacaucuc                                                   20


<210>  5336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5336
cacagaaaua caaacuacca                                                   20


<210>  5337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5337
guggugauau ccccuuuauc                                                   20


<210>  5338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5338
ccaccgaucc cacagaaaua                                                   20


<210>  5339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5339
ccuuuaucgu uuuuauugag                                                   20


<210>  5340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5340
uuuuuauuga gucuauuuga                                                   20


<210>  5341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5341
aauagacuca auaaaaacga                                                   20


<210>  5342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5342
auaaaauagg uagaccgcua                                                   20


<210>  5343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5343
uuucaaaaaa ccagcaccug                                                   20


<210>  5344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5344
aggugcuggu uuuuugaaaa                                                   20


<210>  5345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5345
augaauccag gugcugguuu                                                   20


<210>  5346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5346
ccuucaguuc ugcucugauc                                                   20


<210>  5347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5347
gagcagaacu gaaggagaua                                                   20


<210>  5348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5348
uaguuauuuu uugucuucug                                                   20


<210>  5349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5349
caauuaaaag aacuagaaaa                                                   20


<210>  5350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5350
aaaauuaaca cccuaacauc                                                   20


<210>  5351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5351
uuucugcuuu cucuuguggg                                                   20


<210>  5352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5352
cugggacaca uuuaaagcag                                                   20


<210>  5353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5353
cacucaaaac cacacaacua                                                   20


<210>  5354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5354
ugaguucuaa uuugauugca                                                   20


<210>  5355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5355
aauuagaacu caggauugag                                                   20


<210>  5356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5356
caacaaacug ucugucagac                                                   20


<210>  5357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5357
acagaacaua cauucuucuc                                                   20


<210>  5358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5358
acagaacucu gcaccccaaa                                                   20


<210>  5359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5359
aggacuugaa cucagcacug                                                   20


<210>  5360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5360
uuguuaauuu ucuggcucau                                                   20


<210>  5361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5361
augagccaga aaauuaacaa                                                   20


<210>  5362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5362
gccuaauauu gacagugggg                                                   20


<210>  5363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5363
gggugcuccu guauuggggg                                                   20


<210>  5364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5364
uaaauauaca cgcccccaau                                                   20


<210>  5365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5365
auucaacaag aagagcuaac                                                   20


<210>  5366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5366
cuuuaccauu auguaauggc                                                   20


<210>  5367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5367
acaaaguuca aaggagacaa                                                   20


<210>  5368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5368
gagacuagga uugcaauccc                                                   20


<210>  5369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5369
uagucucuga uaaaacagac                                                   20


<210>  5370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5370
cugcuuuuuu uuugcuuucc                                                   20


<210>  5371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5371
aacaagcaaa uggaaagcaa                                                   20


<210>  5372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5372
uccuccaucc cuuuauuuug                                                   20


<210>  5373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5373
cuuuauuuug agccaaugag                                                   20


<210>  5374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5374
cacaugcaaa gacacucauu                                                   20


<210>  5375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5375
aauuugccag ucugugucuu                                                   20


<210>  5376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5376
aauucacaca uagcaauauu                                                   20


<210>  5377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5377
ugucauuaug auccuaguug                                                   20


<210>  5378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5378
uaaugacagg aucaaauuca                                                   20


<210>  5379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5379
uaguugguua uuuugcccgu                                                   20


<210>  5380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5380
guuaacgggc aaaauaacca                                                   20


<210>  5381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5381
cugcauuugc uugucuguaa                                                   20


<210>  5382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5382
uuuacagaca agcaaaugca                                                   20


<210>  5383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5383
agccaaacua agcuucauaa                                                   20


<210>  5384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5384
uacaagccag aaaagagugg                                                   20


<210>  5385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5385
cucugcagaa auccuacaag                                                   20


<210>  5386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5386
gcuguuaguc ugaugggcuu                                                   20


<210>  5387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5387
gacuaacagc agaucucucu                                                   20


<210>  5388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5388
ugguggaucu gaugauuaug                                                   20


<210>  5389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5389
accaagauug aaaugaagga                                                   20


<210>  5390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5390
gaugauuaug ugucuugggg                                                   20


<210>  5391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5391
gauccaccaa gauugaaaug                                                   20


<210>  5392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5392
ucagauccac caagauugaa                                                   20


<210>  5393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5393
uugugguguu cucuguauuu                                                   20


<210>  5394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5394
aggagaacuu ccccaaccua                                                   20


<210>  5395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5395
ugaagagugu uuucuaacuu                                                   20


<210>  5396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5396
cuuucaggua caccaaucaa                                                   20


<210>  5397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5397
aacguagauu uggucuuuuc                                                   20


<210>  5398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5398
acguuugauu gguguaccug                                                   20


<210>  5399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5399
ugucuucucg cuuuauuuca                                                   20


<210>  5400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5400
aauuaaugaa auaaagcgag                                                   20


<210>  5401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5401
ucaaucacug auauccuuuc                                                   20


<210>  5402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5402
cugauauccu uucuucugcu                                                   20


<210>  5403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5403
gugauugaag aucaaauuaa                                                   20


<210>  5404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5404
uuucuucugc uugauugaau                                                   20


<210>  5405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5405
agcagaagaa aggauaucag                                                   20


<210>  5406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5406
gcugucgaag cuuguguaua                                                   20


<210>  5407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5407
ggucauuuaa gcucuucucu                                                   20


<210>  5408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5408
caaggaagcu aaaaaccuug                                                   20


<210>  5409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5409
aacucauucu ccauccaguu                                                   20


<210>  5410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5410
aguuuuguuc ccuugcuggu                                                   20


<210>  5411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5411
caacuccuca ccagcaaggg                                                   20


<210>  5412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5412
uuuggaggag aagagguguu                                                   20


<210>  5413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5413
uugugguuuu aucuaccuuu                                                   20


<210>  5414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5414
accuuugguc uuugauguug                                                   20


<210>  5415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5415
aagaccaaag guagauaaaa                                                   20


<210>  5416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5416
guaggucacc aacaucaaag                                                   20


<210>  5417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5417
acaaaaagga cacccacacc                                                   20


<210>  5418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5418
acaucaacaa aaaggacacc                                                   20


<210>  5419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5419
ccagcagagg cugcagaaca                                                   20


<210>  5420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5420
ggcagcaaua uuugcuguuc                                                   20


<210>  5421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5421
uuccucugga aacaucgucc                                                   20


<210>  5422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5422
ucccagagca cgaagguguc                                                   20


<210>  5423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5423
gagcuugaau gccguaccgg                                                   20


<210>  5424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5424
ggagaagcug ucugcugccu                                                   20


<210>  5425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5425
gaacaaaagg cagcagacag                                                   20


<210>  5426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5426
agagaggcag uaggccuugc                                                   20


<210>  5427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5427
caggucgauu ucagagugcu                                                   20


<210>  5428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5428
accugggaug caggagcuug                                                   20


<210>  5429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5429
ccuggucugc ugguugugaa                                                   20


<210>  5430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5430
cacugggacu ugcuggacag                                                   20


<210>  5431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5431
ccugucuucu gugucgaucu                                                   20


<210>  5432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5432
acacagaaga caggugauuu                                                   20


<210>  5433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5433
cacugggagc uguagacugg                                                   20


<210>  5434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5434
cuuguuuuuu gagguggagu                                                   20


<210>  5435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5435
gcacaaucuc ggcccacugc                                                   20


<210>  5436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5436
cggcccacug caaccuuugc                                                   20


<210>  5437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5437
cuugaaacca ggaggcaaag                                                   20


<210>  5438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5438
cagcuacucc ggaggcugag                                                   20


<210>  5439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5439
ccacuaaaaa uacaaaaaau                                                   20


<210>  5440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5440
caaggucagg aguucgagac                                                   20


<210>  5441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5441
acccaccuca gccuccuaga                                                   20


<210>  5442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5442
cagcacucua ggaggcugag                                                   20


<210>  5443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5443
caggugucag ccaccacgcc                                                   20


<210>  5444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5444
gaaaauaugg cugggcgugg                                                   20


<210>  5445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5445
cccucucuuu gcccuaaacc                                                   20


<210>  5446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5446
cacguucaaa uuuaaaacau                                                   20


<210>  5447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5447
ucuaacuggg auucuuuaaa                                                   20


<210>  5448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5448
aacugggauu cuuuaaauag                                                   20


<210>  5449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5449
caguuagaug auuuuuauuu                                                   20


<210>  5450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5450
uacuauuuaa agaaucccag                                                   20


<210>  5451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5451
aaugcugccu uauccaaaua                                                   20


<210>  5452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5452
aaauaauaaa aguaaauuau                                                   20


<210>  5453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5453
ucauuaaauu gugacuuauu                                                   20


<210>  5454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5454
aucuucauua aauugugacu                                                   20


<210>  5455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5455
acuaacauca aucuucauua                                                   20


<210>  5456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5456
uuauauucuu gaaaucagcc                                                   20


<210>  5457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5457
gccauauggu ugugugugua                                                   20


<210>  5458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5458
uuauguaccu uuaaaaauau                                                   20


<210>  5459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5459
cugaaaauuu uuacauuugg                                                   20


<210>  5460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5460
aguuauucuu augccaaaug                                                   20


<210>  5461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5461
uauucucugg ccugugucuu                                                   20


<210>  5462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5462
accuuuaacu guaaagacac                                                   20


<210>  5463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5463
uuuuugcugu uucaagacag                                                   20


<210>  5464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5464
uuuuguuugu acuuuggaag                                                   20


<210>  5465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5465
guggucuuuu agagggggau                                                   20


<210>  5466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5466
cccucuaaaa gaccacggau                                                   20


<210>  5467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5467
cccucacuga cucacagcau                                                   20


<210>  5468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5468
gaaaccuugc caugcuguga                                                   20


<210>  5469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5469
cuuucugcca cacagcaguu                                                   20


<210>  5470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5470
uuccagcugc cucagaacug                                                   20


<210>  5471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5471
agaugcuuag auugucaggc                                                   20


<210>  5472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5472
ggauaucuuu ccagcugccu                                                   20


<210>  5473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5473
aagcaucugg auaucuuucc                                                   20


<210>  5474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5474
caagccuggc cugacaaucu                                                   20


<210>  5475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5475
gugaccuugc uuaggugaag                                                   20


<210>  5476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5476
gagccccugc accaacaugc                                                   20


<210>  5477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5477
agcucaccuc uccagcuaca                                                   20


<210>  5478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5478
uggaacuagg uaaacucaca                                                   20


<210>  5479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5479
uuuucuuuuu cuaaauagca                                                   20


<210>  5480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5480
uuauuuauuc cauacucauu                                                   20


<210>  5481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5481
aaugcauaau acauuucaau                                                   20


<210>  5482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5482
ucuauaauau aaugcaaaag                                                   20


<210>  5483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5483
gcaaaccggg aaacugucuc                                                   20


<210>  5484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5484
ucccaccuca gccccgagua                                                   20


<210>  5485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5485
uggcucuuug cagccucaac                                                   20


<210>  5486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5486
ugccauugca cuccagcaug                                                   20


<210>  5487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5487
cccaaaacag acaguauaaa                                                   20


<210>  5488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5488
aaucacccaa aacagacagu                                                   20


<210>  5489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5489
uuaucaaauc acccaaaaca                                                   20


<210>  5490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5490
gggcauauca uuaucaaauc                                                   20


<210>  5491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5491
uguguuucuu gugccugggu                                                   20


<210>  5492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5492
uggcucacug caagcucugc                                                   20


<210>  5493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5493
uggcuaacac agugaaaccu                                                   20


<210>  5494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5494
ccugaccucg ugaucugccc                                                   20


<210>  5495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5495
cgaggucagg agauugagac                                                   20


<210>  5496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5496
gcccgccugg gccucccaaa                                                   20


<210>  5497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5497
cagcacuuug ggaggcccag                                                   20


<210>  5498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5498
uugaagaaau aauggccuag                                                   20


<210>  5499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5499
cagccccuuu aagagaggga                                                   20


<210>  5500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5500
uucaggaaau cacagccccu                                                   20


<210>  5501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5501
guaagcuaug ggacaacacu                                                   20


<210>  5502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5502
aacacugaaa agagcaucag                                                   20


<210>  5503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5503
gagaacuuga aaacacaaua                                                   20


<210>  5504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5504
uuucuucuac agugucuacu                                                   20


<210>  5505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5505
guuaaucugu uguuaauccu                                                   20


<210>  5506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5506
guuguuaauc cuguccagcg                                                   20


<210>  5507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5507
uguccagcgu auuuuuuuuu                                                   20


<210>  5508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5508
caccacuaaa cuccagccug                                                   20


<210>  5509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5509
gcucacugca accuccaccu                                                   20


<210>  5510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5510
cuaauaaaaa uacacaaauu                                                   20


<210>  5511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5511
ccugagguca ggaguucaag                                                   20


<210>  5512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5512
gccucggucu cccaaagugu                                                   20


<210>  5513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5513
caacacuuug ggagaccgag                                                   20


<210>  5514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5514
cuaauuuugu uuuuaucucu                                                   20


<210>  5515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5515
cuagaaguuu gauuuagguc                                                   20


<210>  5516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5516
aacuucuaga gauaaaaaca                                                   20


<210>  5517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5517
uucucugcua guucuaagau                                                   20


<210>  5518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5518
uagaacuagc agagaaggau                                                   20


<210>  5519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5519
ucuaauaacu ucccaguucu                                                   20


<210>  5520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5520
accaaugaga aacaccaaga                                                   20


<210>  5521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5521
aucaaccaau gagaaacacc                                                   20


<210>  5522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5522
aauaaaaaau uggcagccau                                                   20


<210>  5523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5523
aacaaaguaa aauucacaag                                                   20


<210>  5524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5524
augggaacac aaaaauauau                                                   20


<210>  5525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5525
ucuugagcuu uguucugagg                                                   20


<210>  5526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5526
auauguaacu caacuaaccu                                                   20


<210>  5527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5527
gacaaauuau aaagcaagac                                                   20


<210>  5528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5528
ugaguacucu accuaaugaa                                                   20


<210>  5529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5529
uuuccaaugc uucuuucccu                                                   20


<210>  5530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5530
cugcugagua cucgagaggg                                                   20


<210>  5531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5531
ggggaagguc ccucucgagu                                                   20


<210>  5532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5532
ccagagcucu cucugucuug                                                   20


<210>  5533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5533
aaggagacca agacagccac                                                   20


<210>  5534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5534
cugggagacg agagacuaag                                                   20


<210>  5535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5535
cuguccuuca uugcucaugu                                                   20


<210>  5536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5536
aauguaauag agugagacuu                                                   20


<210>  5537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5537
agcauuccau acacauuugu                                                   20


<210>  5538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5538
cuacuugucu aacaaaggac                                                   20


<210>  5539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5539
gcugggagcu aguaaaaaca                                                   20


<210>  5540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5540
gaauuuuaaa aauguguggc                                                   20


<210>  5541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5541
auugcuuauu aguagaggau                                                   20


<210>  5542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5542
ucuacuaaua agcaauagau                                                   20


<210>  5543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5543
gcugcuaaaa gccaacacca                                                   20


<210>  5544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5544
cgaacugguu uccaucagcu                                                   20


<210>  5545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5545
aggcauucag aaugguggcg                                                   20


<210>  5546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5546
ucuucuuucu ugauucuuuu                                                   20


<210>  5547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5547
agaaagaaga agaugcuaac                                                   20


<210>  5548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5548
caaaaaaaaa aaaaaaagaa                                                   20


<210>  5549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5549
cggcucacug uaaccucugc                                                   20


<210>  5550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5550
cuugaaccag ggaggcagag                                                   20


<210>  5551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5551
cagcuacuug agaggcugag                                                   20


<210>  5552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5552
cuaccaaaaa uacaaaauua                                                   20


<210>  5553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5553
cuugagguca ggaguucaag                                                   20


<210>  5554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5554
aggcaggugc aucacuugag                                                   20


<210>  5555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5555
cccaaaaugc ugggauuaca                                                   20


<210>  5556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5556
cagcauuuug ggagaucgag                                                   20


<210>  5557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5557
agaaggggcu gggaguggug                                                   20


<210>  5558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5558
cguuauagau guugauaaaa                                                   20


<210>  5559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5559
auaacgagau guacagcacc                                                   20


<210>  5560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5560
acaucuauaa cgagauguac                                                   20


<210>  5561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5561
gcaaaaauga ccaaauaacu                                                   20


<210>  5562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5562
guccuagaau ugucuuaaaa                                                   20


<210>  5563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5563
cacauugcug uaucauaguu                                                   20


<210>  5564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5564
uaguuguguu cacugaacau                                                   20


<210>  5565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5565
guagagcccc ugaauauguu                                                   20


<210>  5566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5566
aguccuguuc gcagggcagg                                                   20


<210>  5567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5567
aguaccuguu gucuauuagg                                                   20


<210>  5568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5568
guucauucac ucauuaauuc                                                   20


<210>  5569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5569
aaguuauaua cauuacaacc                                                   20


<210>  5570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5570
gaggaaaguu uucaauuucu                                                   20


<210>  5571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5571
uguaccuuca auuucugucu                                                   20


<210>  5572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5572
uagacagaaa uugaagguac                                                   20


<210>  5573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5573
cugagucgcu uaaugucuca                                                   20


<210>  5574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5574
cuucaacaca cuguagaaag                                                   20


<210>  5575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5575
uaggauaccu gaaauccugc                                                   20


<210>  5576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5576
uaggaucucu ucaacacacu                                                   20


<210>  5577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5577
ugcuuuaguc gagaaccaau                                                   20


<210>  5578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5578
uugguucucg acuaaagcag                                                   20


<210>  5579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5579
gcugggagga uugugggguc                                                   20


<210>  5580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5580
ucccagcuga uuaugccaac                                                   20


<210>  5581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5581
uggacugagc caaaaagugc                                                   20


<210>  5582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5582
uucccuucac uccccaggag                                                   20


<210>  5583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5583
cauuuagaau ugcaaggaaa                                                   20


<210>  5584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5584
caugagguau uaauagugau                                                   20


<210>  5585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5585
cuauuaauac cucaugagau                                                   20


<210>  5586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5586
aguuauuuac agauggauuu                                                   20


<210>  5587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5587
guaaauaacu ggauauguua                                                   20


<210>  5588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5588
aucuguaaau aacuggauau                                                   20


<210>  5589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5589
aauccaucug uaaauaacug                                                   20


<210>  5590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5590
cccacacaaa uaucaaaucc                                                   20


<210>  5591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5591
acaauguggc gugaacaaca                                                   20


<210>  5592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5592
aacugggagg ccaaguuugu                                                   20


<210>  5593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5593
uccaacccca gcaagucaca                                                   20


<210>  5594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5594
ucuaauaguc ugcuguauuc                                                   20


<210>  5595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5595
ccuagaguuc ucugaauaca                                                   20


<210>  5596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5596
accauauaua ucuccuagag                                                   20


<210>  5597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5597
uugcaucaac cauauauauc                                                   20


<210>  5598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5598
ucuuugcauc aaccauauau                                                   20


<210>  5599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5599
cacucacugg ccacacacuu                                                   20


<210>  5600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5600
cagagguggg gguagaggag                                                   20


<210>  5601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5601
uuguuacagg ccugaaaagu                                                   20


<210>  5602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5602
uggauauauu accuuguguu                                                   20


<210>  5603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5603
aagaugcuuc uauggccuuc                                                   20


<210>  5604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5604
cagcucacug caagcucugc                                                   20


<210>  5605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5605
uggguucaug ccauucuccu                                                   20


<210>  5606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5606
cgccuggcua acuuuuuuuu                                                   20


<210>  5607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5607
uggcuaacau ggugaaaccc                                                   20


<210>  5608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5608
agaccauccu ggcuaacaug                                                   20


<210>  5609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5609
ccugaccucg ugaucugccc                                                   20


<210>  5610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5610
cgaggucagg agaucgagac                                                   20


<210>  5611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5611
gcccgucccg gccucccaaa                                                   20


<210>  5612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5612
cagcacuuug ggaggccggg                                                   20


<210>  5613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5613
guauaguagc aauaauagaa                                                   20


<210>  5614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5614
cuuguuuuuc cuuuuauaaa                                                   20


<210>  5615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5615
cuaaauuuau aaaaggaaaa                                                   20


<210>  5616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5616
cuaacauaca gccuggaaca                                                   20


<210>  5617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5617
cuucuaagaa acauauauga                                                   20


<210>  5618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5618
uugauguaaa uauuuuaaag                                                   20


<210>  5619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5619
augauauccc uucuaagaaa                                                   20


<210>  5620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5620
uguaauuucu ucuaaauuac                                                   20


<210>  5621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5621
guaauuuaga agaaauuaca                                                   20


<210>  5622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5622
uuuaaaugac cuucaccuuu                                                   20


<210>  5623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5623
cacuuaagac ugggcugagu                                                   20


<210>  5624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5624
agucuccuca cucgcagaag                                                   20


<210>  5625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5625
gaagagggcg augcugccac                                                   20


<210>  5626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5626
cccucuucag auaaugacac                                                   20


<210>  5627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5627
gacacguucu gaucguguga                                                   20


<210>  5628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5628
gaacguguca gauugagaaa                                                   20


<210>  5629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5629
ugugaaugug aaauugguuu                                                   20


<210>  5630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5630
gagugcagag gagauuauuu                                                   20


<210>  5631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5631
ccucugcacu cagauauacu                                                   20


<210>  5632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5632
uuaaauaauc uccucugcac                                                   20


<210>  5633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5633
gccaaauggg aauaaaaggg                                                   20


<210>  5634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5634
aaccaucugc caaaugggaa                                                   20


<210>  5635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5635
gcacgguucu uugugacacu                                                   20


<210>  5636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5636
auaaguaagc cuucaacuaa                                                   20


<210>  5637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5637
cauucguuug uuugaaccuc                                                   20


<210>  5638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5638
aaaaccugcu ucuguaacug                                                   20


<210>  5639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5639
agaagacagu aauuaacccg                                                   20


<210>  5640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5640
gaauccagaa gacaguaauu                                                   20


<210>  5641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5641
gguuugucac uuuuaucuuu                                                   20


<210>  5642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5642
uucauccauc auaccuguuc                                                   20


<210>  5643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5643
aucauaccug uuccuaauuu                                                   20


<210>  5644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5644
uaccuguucc uaauuuagua                                                   20


<210>  5645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5645
acuuuaaaga aauguggucu                                                   20


<210>  5646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5646
guugcugcug cuuaucuuuu                                                   20


<210>  5647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5647
uuuucaugca ccuagcuggu                                                   20


<210>  5648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5648
uugccccagc ucccuggacu                                                   20


<210>  5649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5649
cuaacagcca accccagguu                                                   20


<210>  5650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5650
acuugccucc ccuccaaaau                                                   20


<210>  5651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5651
cacaauuuaa auucaaacuu                                                   20


<210>  5652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5652
uaauuguauc ucacaauuua                                                   20


<210>  5653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5653
agaguuaguu uaaacagauu                                                   20


<210>  5654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5654
guuuaaacua acucuagauu                                                   20


<210>  5655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5655
auuauuacca uaauugauca                                                   20


<210>  5656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5656
auuaugguaa uaauugauaa                                                   20


<210>  5657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5657
ucugcaguuu caagcuaucu                                                   20


<210>  5658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5658
gcaguuucaa gcuaucuaac                                                   20


<210>  5659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5659
aacagguuca cuuaccucuu                                                   20


<210>  5660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5660
ggugcccaca gcaacuauag                                                   20


<210>  5661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5661
ugaagggaca ggacuagcca                                                   20


<210>  5662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5662
ugaggaaaau gugcaucaug                                                   20


<210>  5663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5663
cugcagauga aacugccuuu                                                   20


<210>  5664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5664
gcagugauuu aacugggacg                                                   20


<210>  5665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5665
ucaaaauuua acugucauuu                                                   20


<210>  5666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5666
cggcucaaaa augacaguua                                                   20


<210>  5667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5667
ugggcuacuu ucuuaugugg                                                   20


<210>  5668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5668
guuaauccug ucagcacugu                                                   20


<210>  5669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5669
ugucagcacu guuacucacc                                                   20


<210>  5670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5670
guguugaccg agugcccuca                                                   20


<210>  5671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5671
gcuuguuuuu uuuguuguug                                                   20


<210>  5672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5672
caaaaaaaaa acaaaaaaaa                                                   20


<210>  5673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5673
caccccugca cuccagccug                                                   20


<210>  5674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5674
cggcucacug ccagcuccgc                                                   20


<210>  5675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5675
uggcuaacac agugaaaccu                                                   20


<210>  5676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5676
ccugaccucg ugaucugccc                                                   20


<210>  5677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5677
cgaggucagg agauggagac                                                   20


<210>  5678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5678
gcccgccucg gccucccaaa                                                   20


<210>  5679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5679
cagcacuuug ggaggccgag                                                   20


<210>  5680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5680
aggggugggc uuugcguugg                                                   20


<210>  5681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5681
ggccaacgca aagcccaccc                                                   20


<210>  5682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5682
uucuuucaca aaaccugucc                                                   20


<210>  5683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5683
gucuaaaugg gccauugcuc                                                   20


<210>  5684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5684
gggcucuggc uucccuuggg                                                   20


<210>  5685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5685
gaacaaacau gaaaccagag                                                   20


<210>  5686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5686
accggucccc uuucucccag                                                   20


<210>  5687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5687
uaagaacugg gagaaagggg                                                   20


<210>  5688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5688
gcauagaguu caaugguuug                                                   20


<210>  5689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5689
uuaucagcau agaguucaau                                                   20


<210>  5690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5690
auggaagcuc cccgucaggu                                                   20


<210>  5691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5691
gagaggcgac acguaagggc                                                   20


<210>  5692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5692
uauuacuaaa ccaguuucag                                                   20


<210>  5693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5693
gugccacccu aucugccauu                                                   20


<210>  5694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5694
gccauuaacg ugaacagaug                                                   20


<210>  5695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5695
guucacguua auggcagaua                                                   20


<210>  5696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5696
gacaauaccc aaaauuacac                                                   20


<210>  5697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5697
cauuggaaaa acaaauaaua                                                   20


<210>  5698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5698
ccucaacaac uuuacuauac                                                   20


<210>  5699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5699
aggaaucccc ucaacaacuu                                                   20


<210>  5700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5700
aggcugauuu cagaauagag                                                   20


<210>  5701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5701
gccuagauaa uugcagaaca                                                   20


<210>  5702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5702
gcugucaaga auuuuauuua                                                   20


<210>  5703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5703
gcauaaauuu uaaauaaaau                                                   20


<210>  5704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5704
uauuauugau gugaaauuuu                                                   20


<210>  5705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5705
auaauaggau uaaaauguaa                                                   20


<210>  5706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5706
aaaauaauaa aaugcuauua                                                   20


<210>  5707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5707
gacuaacaua cugugcauuu                                                   20


<210>  5708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5708
caagacuugu uuggaaguag                                                   20


<210>  5709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5709
gaaaauucca uauguuguca                                                   20


<210>  5710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5710
gucaacacaa uuaaaugcuu                                                   20


<210>  5711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5711
ugugguggag cacuaguuuu                                                   20


<210>  5712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5712
ucuuagagaa agcaguuuua                                                   20


<210>  5713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5713
agcaagaaaa agcugcagag                                                   20


<210>  5714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5714
gggaacacuu uccuucugca                                                   20


<210>  5715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5715
uccuagcucu ccucugccuc                                                   20


<210>  5716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5716
uagcugcugu gccccugugc                                                   20


<210>  5717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5717
gugcccucgc gcagagcagg                                                   20


<210>  5718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5718
caucugugcc cucgcgcaga                                                   20


<210>  5719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5719
acucuaaccc caccccugcc                                                   20


<210>  5720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5720
cggacaccug uuagcuugau                                                   20


<210>  5721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5721
agcuaacagg uguccgugau                                                   20


<210>  5722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5722
ugaauuauuu uauguugcuu                                                   20


<210>  5723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5723
auauaagcaa cauaaaauaa                                                   20


<210>  5724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5724
uaauuuuaaa agaaaggucu                                                   20


<210>  5725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5725
auuuagaccu uucuuuuaaa                                                   20


<210>  5726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5726
gaggcaauca uuccaaacau                                                   20


<210>  5727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5727
uuccaaacau cuuuuucuuc                                                   20


<210>  5728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5728
uuuucuucuu gguauuacua                                                   20


<210>  5729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5729
uaugaacgcu aucauucaaa                                                   20


<210>  5730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5730
uucaaaacag aucauuggaa                                                   20


<210>  5731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5731
guuuugaaug auagcguuca                                                   20


<210>  5732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5732
uuggaauucc uaaaaucauu                                                   20


<210>  5733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5733
uucagcucug ugauggcauc                                                   20


<210>  5734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5734
cagagcugaa ugauuuuagg                                                   20


<210>  5735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5735
uggccagugg aaggaaggcu                                                   20


<210>  5736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5736
cgacaccgaa gacgacagug                                                   20


<210>  5737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5737
ucucagggaa aaaaauucaa                                                   20


<210>  5738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5738
uacuguuucu ugaauuuuuu                                                   20


<210>  5739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5739
guaccuuagg uuaucuuacu                                                   20


<210>  5740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5740
aucuguaccu uagguuaucu                                                   20


<210>  5741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5741
agugaagaac uuuuagcguu                                                   20


<210>  5742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5742
uagccaaaag gccaagaagc                                                   20


<210>  5743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5743
cuucuuggcc uuuuggcuaa                                                   20


<210>  5744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5744
aacuugccgu gaauuaaauu                                                   20


<210>  5745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5745
aaauuuaauu cacggcaagu                                                   20


<210>  5746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5746
cucauccagu gguauuggag                                                   20


<210>  5747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5747
agugguauug gagauauagu                                                   20


<210>  5748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5748
ccaauaccac uggaugagag                                                   20


<210>  5749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5749
ggcaaaacag aaagcccuga                                                   20


<210>  5750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5750
ucaggcaaaa cagaaagccc                                                   20


<210>  5751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5751
ccuggguucc uuauuuaagc                                                   20


<210>  5752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5752
uucuuugagc uuuuugaacu                                                   20


<210>  5753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5753
guucaaaaag cucaaagaaa                                                   20


<210>  5754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5754
uccagcauug cccuauugac                                                   20


<210>  5755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5755
guaggcuuuu gaacuuugac                                                   20


<210>  5756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5756
uaagacccuu gcaaacuccc                                                   20


<210>  5757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5757
gggaguuugc aagggucuua                                                   20


<210>  5758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5758
accgggcugu guugcgaggc                                                   20


<210>  5759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5759
gaagcccuug ugaggccgug                                                   20


<210>  5760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5760
auacuuuggc ugugugaauc                                                   20


<210>  5761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5761
guaggcaacc acacccagua                                                   20


<210>  5762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5762
gugagagggu cagagaguau                                                   20


<210>  5763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5763
aucuaaugac agagugaguu                                                   20


<210>  5764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5764
aaugacagag ugaguuuacu                                                   20


<210>  5765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5765
aguggcuuug acuaaaugua                                                   20


<210>  5766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5766
gaaaagacaa uaaagacuuc                                                   20


<210>  5767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5767
aguagauuau ucuugagacc                                                   20


<210>  5768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5768
acuugauuca ucugaaaaga                                                   20


<210>  5769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5769
uuuucaaauu gacuuuugaa                                                   20


<210>  5770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5770
caaaaugauc aguguucaga                                                   20


<210>  5771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5771
uuuugugaug acuucuaaaa                                                   20


<210>  5772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5772
guguucagag gaagagcuuu                                                   20


<210>  5773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5773
uuauaccaug uggaagguca                                                   20


<210>  5774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5774
aucauuauac cauguggaag                                                   20


<210>  5775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5775
cuuaccauaa accaaguaug                                                   20


<210>  5776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5776
acaaaaugcu uucaagaaau                                                   20


<210>  5777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5777
ggcauuucau ggaaauuaca                                                   20


<210>  5778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5778
gcuuuauuug uuccucuuaa                                                   20


<210>  5779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5779
aguaccauca gguaagagga                                                   20


<210>  5780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5780
gguaagagga auguauguug                                                   20


<210>  5781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5781
acgacaguuc caacauacau                                                   20


<210>  5782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5782
gcacggguca auaaaguauc                                                   20


<210>  5783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5783
acccaggccc cagaaagccc                                                   20


<210>  5784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5784
cccugcaccg gcaucuaccc                                                   20


<210>  5785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5785
uuuuuuuuuu uuugagaugg                                                   20


<210>  5786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5786
caaaaaaaaa aaaaggauac                                                   20


<210>  5787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5787
ugccaccaca cuccagccug                                                   20


<210>  5788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5788
uggcucauug caagcuccac                                                   20


<210>  5789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5789
cagcuacucg ggagguggag                                                   20


<210>  5790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5790
cuacuaaaaa uacaaaaaaa                                                   20


<210>  5791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5791
uggugaaacc ccaucucuac                                                   20


<210>  5792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5792
cuugagguca ggaguucgaa                                                   20


<210>  5793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5793
uccugccuug gccucccaaa                                                   20


<210>  5794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5794
uagcacuuug ggaggccaag                                                   20


<210>  5795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5795
uuaaaguggg cacagccaca                                                   20


<210>  5796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5796
cgugacucuc agaccaggag                                                   20


<210>  5797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5797
uucaagauag ugaggcccuc                                                   20


<210>  5798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5798
ugaacgaucu cgugacucuc                                                   20


<210>  5799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5799
auugacagug uuggucaaga                                                   20


<210>  5800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5800
ugaccaacac ugucaauuga                                                   20


<210>  5801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5801
uuuuaagguu ucuaccaucu                                                   20


<210>  5802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5802
caacucugaa auaaaaacuu                                                   20


<210>  5803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5803
gcucaaagaa aaagaccuua                                                   20


<210>  5804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5804
cucuuuuuaa augacuucuc                                                   20


<210>  5805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5805
ucauaaagcc auagcuuuuc                                                   20


<210>  5806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5806
cauaauugca augcaaaagu                                                   20


<210>  5807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5807
uaaagagguc ugaaaaugag                                                   20


<210>  5808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5808
gccacauguu cagugagcuc                                                   20


<210>  5809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5809
agagcucacu gaacaugugg                                                   20


<210>  5810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5810
uuucuaaaca gacauaucca                                                   20


<210>  5811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5811
cuaauaaacu ugugcucaac                                                   20


<210>  5812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5812
acugaagagc accugcuucc                                                   20


<210>  5813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5813
uuggcaaacu ucaaacacag                                                   20


<210>  5814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5814
aauguauauu aaucuuuggc                                                   20


<210>  5815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5815
gagaaaaggc acaacaugaa                                                   20


<210>  5816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5816
uuguuauuug uauagaauuu                                                   20


<210>  5817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5817
uccugagcaa agugugcacc                                                   20


<210>  5818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5818
gaacgaaaca caaguuccuc                                                   20


<210>  5819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5819
cagcgaggac agggggacac                                                   20


<210>  5820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5820
caucuguuug gauccuagag                                                   20


<210>  5821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5821
guuuggaucc uagagucuuc                                                   20


<210>  5822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5822
aaacagaugu gaucccagcg                                                   20


<210>  5823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5823
uagagucuuc cagcugaacu                                                   20


<210>  5824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5824
ccaacaccua uaagagcgug                                                   20


<210>  5825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5825
gucgagacag ucgcuuccac                                                   20


<210>  5826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5826
uccucccaau guuagccaaa                                                   20


<210>  5827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5827
ucccaauguu agccaaacag                                                   20


<210>  5828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5828
cuaugcaaca acaagccaag                                                   20


<210>  5829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5829
gcucuuccuu caguccuaau                                                   20


<210>  5830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5830
gugccuugau agcaguucuc                                                   20


<210>  5831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5831
aggcacagau uaggacugaa                                                   20


<210>  5832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5832
cagguuggua uugcccaccu                                                   20


<210>  5833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5833
ccccuguaaa guaggugggc                                                   20


<210>  5834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5834
cacagcuccg agagguuaug                                                   20


<210>  5835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5835
ccuccauaac cucucggagc                                                   20


<210>  5836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5836
ggcagcacac agcuuuagag                                                   20


<210>  5837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5837
aaccaccaaa uaaaacacug                                                   20


<210>  5838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5838
cacugcaaca accucugccu                                                   20


<210>  5839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5839
cuacuaaaaa uacaaaaaac                                                   20


<210>  5840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5840
cuugcgccca ggaguuuaaa                                                   20


<210>  5841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5841
accaaccuug gccugccaaa                                                   20


<210>  5842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5842
cuaaucagaa uuucuaugau                                                   20


<210>  5843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5843
gaauuucuau gaucaaauga                                                   20


<210>  5844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5844
uagaaauucu gauuagugau                                                   20


<210>  5845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5845
aaugacauga aucauuguuu                                                   20


<210>  5846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5846
uuguuuccac aacugcagug                                                   20


<210>  5847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5847
caugagcugc cuggcacagc                                                   20


<210>  5848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5848
ugauuauaca caauaaacaa                                                   20


<210>  5849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5849
agaugaacaa acauguauuu                                                   20


<210>  5850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5850
aaugccaaaa accacggacu                                                   20


<210>  5851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5851
caugccucua aguuuaaauc                                                   20


<210>  5852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5852
auaucacaug ccucuaaguu                                                   20


<210>  5853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5853
gaaugggggu gcagucauga                                                   20


<210>  5854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5854
ugagaccagu uagacaacag                                                   20


<210>  5855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5855
cuguccuguu gucuaacugg                                                   20


<210>  5856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5856
uggcuucugg ugagauugac                                                   20


<210>  5857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5857
caccagaagc caagaucccu                                                   20


<210>  5858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5858
guaggcaggg agacccugac                                                   20


<210>  5859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5859
cauucuuuuc ugugcguaau                                                   20


<210>  5860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5860
gaguagagug gagaucgaag                                                   20


<210>  5861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5861
ccacucuacu cagauuacgc                                                   20


<210>  5862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5862
aaggccugaa uacauaguaa                                                   20


<210>  5863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5863
gccgcaaugg aaauugugug                                                   20


<210>  5864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5864
cacaauuucc auugcggcag                                                   20


<210>  5865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5865
agcacuacuu cugaaugcaa                                                   20


<210>  5866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5866
uguuacuggc agugcauaca                                                   20


<210>  5867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5867
gugaucaaag cagauuaaag                                                   20


<210>  5868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5868
cugauguaug cacugccagu                                                   20


<210>  5869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5869
aagcagauua aagaaagacc                                                   20


<210>  5870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5870
gcuuugauca cugauguaug                                                   20


<210>  5871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5871
ucacuccaag aaggcagggg                                                   20


<210>  5872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5872
caacaaaauc uucacuccaa                                                   20


<210>  5873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5873
gccgccaugg uauagacuuc                                                   20


<210>  5874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5874
ggaacaccgu acagaagaau                                                   20


<210>  5875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5875
aggagggaag agaguuaggu                                                   20


<210>  5876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5876
ccagcugaac aaugccacuc                                                   20


<210>  5877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5877
ccaaagcuuc uucucaucac                                                   20


<210>  5878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5878
ggugacauuu gagugaauuu                                                   20


<210>  5879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5879
uuccuuucug caaauucacu                                                   20


<210>  5880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5880
ccuaggcuug uaucuuuccu                                                   20


<210>  5881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5881
gcgcaaaccc ucucaaggcu                                                   20


<210>  5882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5882
ugcuaaaacc uacaccacau                                                   20


<210>  5883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5883
uucuuauucc ugaguugaga                                                   20


<210>  5884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5884
cuuggcagca ugaaagcaaa                                                   20


<210>  5885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5885
aagccaccag caaaccuugc                                                   20


<210>  5886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5886
cccccaaagc ccugcucucu                                                   20


<210>  5887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5887
agacaggcuc ugaccuccug                                                   20


<210>  5888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5888
gguguaugag ccuggaguug                                                   20


<210>  5889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5889
gagaugucca cucacagugg                                                   20


<210>  5890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5890
cagaugcuga cccccugccc                                                   20


<210>  5891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5891
uggcuuuagg aaccccacac                                                   20


<210>  5892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5892
gcugucagca ccuugggaac                                                   20


<210>  5893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5893
gugcccucgg ugcugccaaa                                                   20


<210>  5894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5894
ucccuguugc uucugcccuc                                                   20


<210>  5895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5895
guucaugaca caggagacac                                                   20


<210>  5896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5896
ccguuguggu guucacagac                                                   20


<210>  5897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5897
uaacccaugu cugugaacac                                                   20


<210>  5898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5898
augcagccaa uccuaaccca                                                   20


<210>  5899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5899
uggacccucg ccugugcuca                                                   20


<210>  5900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5900
uggagcucaa gucaguuguu                                                   20


<210>  5901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5901
uacaacaagg gaacaacuga                                                   20


<210>  5902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5902
gugccuugaa aaacaccaca                                                   20


<210>  5903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5903
guuugcagag uuguuuacua                                                   20


<210>  5904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5904
auaaguaaug guugaacaca                                                   20


<210>  5905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5905
ugcaaaauag cccaagcuaa                                                   20


<210>  5906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5906
cagcacuuug ggaggccaag                                                   20


<210>  5907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5907
gccugccuug gccucccaaa                                                   20


<210>  5908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5908
ucccaccuca gccuccugag                                                   20


<210>  5909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5909
cuugagccca uucgugcgcc                                                   20


<210>  5910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5910
uaaacgucuc ugcucuucuc                                                   20


<210>  5911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5911
uugcccccuc acccacagag                                                   20


<210>  5912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5912
gccccauguu ccuauagcca                                                   20


<210>  5913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5913
cuuucuuaau cugccccaug                                                   20


<210>  5914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5914
cucccacaac aguuguaaca                                                   20


<210>  5915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5915
cauguaugug uauacaaagg                                                   20


<210>  5916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5916
uuaccaacau uuuggggacc                                                   20


<210>  5917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5917
acuagcacug cagcacccug                                                   20


<210>  5918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5918
aaaugacaag auuucuguua                                                   20


<210>  5919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5919
ugucauuuag auuuuuauua                                                   20


<210>  5920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5920
ucaccuuccc ucauuuaaaa                                                   20


<210>  5921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5921
caucgucacc uucccucauu                                                   20


<210>  5922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5922
ucucaucguc accuucccuc                                                   20


<210>  5923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5923
uaaucaucuc aucgucaccu                                                   20


<210>  5924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5924
ucauaaucau cucaucguca                                                   20


<210>  5925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5925
guggaauuag acaccacaaa                                                   20


<210>  5926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5926
caaauaaugu auuuaacacu                                                   20


<210>  5927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5927
gcugagccag gcgagagacu                                                   20


<210>  5928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5928
ggacggcuug uucaggcucu                                                   20


<210>  5929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5929
gagccugaac aagccgucca                                                   20


<210>  5930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5930
ugacacugua cuccagccug                                                   20


<210>  5931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5931
cggcucacug caagcucugc                                                   20


<210>  5932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5932
cuacuaaaaa uacaaaaaaa                                                   20


<210>  5933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5933
uggcuaacac ggugaaaccc                                                   20


<210>  5934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5934
agaccauccu ggcuaacacg                                                   20


<210>  5935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5935
ccugaccucg ugacccgccc                                                   20


<210>  5936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5936
cagccuccca aagugcuggg                                                   20


<210>  5937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5937
cagcacuuug ggaggcugag                                                   20


<210>  5938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5938
ccaaaaaaaa uaaaaaggcc                                                   20


<210>  5939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5939
uggcuaacac agugaaaccc                                                   20


<210>  5940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5940
cgaccauccu ggcuaacaca                                                   20


<210>  5941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5941
ccugaccuug ugauccgccc                                                   20


<210>  5942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5942
caaggucagg agaucgcgac                                                   20


<210>  5943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5943
gcccgccucg gccucccaaa                                                   20


<210>  5944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5944
caacacuuug ggaggccgag                                                   20


<210>  5945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5945
cugaguccca aagugugcuc                                                   20


<210>  5946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5946
uaccaauaaa ccucucuauc                                                   20


<210>  5947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5947
uccuuuuuuc uucagcugug                                                   20


<210>  5948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5948
acaguugaac agugcucacg                                                   20


<210>  5949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5949
ggaauucugg ccauuuugag                                                   20


<210>  5950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5950
gaacccucaa aauggccaga                                                   20


<210>  5951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5951
ucaguugacu gggaaaucag                                                   20


<210>  5952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5952
ccuguacagu aauuaauagg                                                   20


<210>  5953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5953
cuuaaccuau uaauuacugu                                                   20


<210>  5954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5954
gagccuauaa cuaacccaug                                                   20


<210>  5955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5955
cgugacuucc caaaaggcau                                                   20


<210>  5956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5956
guguaauuuu cuaauccguc                                                   20


<210>  5957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5957
guccugcauu aucuauggcu                                                   20


<210>  5958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5958
auggcucuug guucauaccu                                                   20


<210>  5959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5959
cuacugagga caagagacag                                                   20


<210>  5960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5960
gagacucacu uuuacuggcu                                                   20


<210>  5961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5961
aauccugucu ucccucauaa                                                   20


<210>  5962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5962
ugucuucccu cauaaauugu                                                   20


<210>  5963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5963
cuguccuugg ggagcuucca                                                   20


<210>  5964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5964
aggcagcaag cacuuacgag                                                   20


<210>  5965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5965
agcaaaggug gagagggacc                                                   20


<210>  5966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5966
guggagaugc ccuguguugu                                                   20


<210>  5967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5967
ccacugauga caaaccaagu                                                   20


<210>  5968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5968
ccuucgacaa cacagggcau                                                   20


<210>  5969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5969
auuuuagcca gcugcuucaa                                                   20


<210>  5970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5970
ucaauuuuag ccagcugcuu                                                   20


<210>  5971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5971
gucacaggaa uuuaauguau                                                   20


<210>  5972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5972
ucugucacag gaauuuaaug                                                   20


<210>  5973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5973
gcuuguauuu guguaauggu                                                   20


<210>  5974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5974
ucagugagga aggugauaca                                                   20


<210>  5975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5975
ccuuccucac ugaggaugaa                                                   20


<210>  5976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5976
uuucauguau acuuggcgua                                                   20


<210>  5977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5977
uuuuuguuuc uuggaagguu                                                   20


<210>  5978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5978
gacacauuag cagugugccu                                                   20


<210>  5979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5979
acaucuucaa gucugguagg                                                   20


<210>  5980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5980
ucaagucugg uaggugaauc                                                   20


<210>  5981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5981
cauuagucuu ccuggagugu                                                   20


<210>  5982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5982
gguguacucu uacagcaaca                                                   20


<210>  5983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5983
uuucaccacc cugcuuucca                                                   20


<210>  5984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5984
ugaauaaugc ugcuaugaau                                                   20


<210>  5985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5985
agggacacuu caguugguuc                                                   20


<210>  5986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5986
aucgagggac acuucaguug                                                   20


<210>  5987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5987
auucauccau cgagggacac                                                   20


<210>  5988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5988
gguguauauu uacaguggaa                                                   20


<210>  5989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5989
cauaguauuu guccuuuugu                                                   20


<210>  5990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5990
augaauuaac uacuccaggu                                                   20


<210>  5991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5991
uguaaaaaua acuccccucc                                                   20


<210>  5992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5992
ccaccauuca uuucuagaau                                                   20


<210>  5993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5993
aagcacuuug agaggccaag                                                   20


<210>  5994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5994
uccugccuug gccucucaaa                                                   20


<210>  5995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5995
guacaaacaa acuagccggg                                                   20


<210>  5996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5996
ccggcuaguu uguuuguaca                                                   20


<210>  5997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5997
uccagccuca gucuccugag                                                   20


<210>  5998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5998
cuugagccca ggagguuaag                                                   20


<210>  5999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  5999
cacuagagac uuaaccuccu                                                   20


<210>  6000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6000
uaaccauuuu uggcucuugu                                                   20


<210>  6001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6001
caguggcuua ugccuguaau                                                   20


<210>  6002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6002
caacacuuug ggaggucaag                                                   20


<210>  6003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6003
uuuuaccuug accucccaaa                                                   20


<210>  6004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6004
cuugaagcca ggagcuuggg                                                   20


<210>  6005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6005
agaccccuau cucuacaaag                                                   20


<210>  6006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6006
cuacaaagaa aaucaaaaac                                                   20


<210>  6007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6007
aaaacuagcu agauauggug                                                   20


<210>  6008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6008
agcuaguuuu ugauuuucuu                                                   20


<210>  6009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6009
ucccaccuca gccucccaag                                                   20


<210>  6010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6010
cuugagcuca ggaguucgag                                                   20


<210>  6011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6011
uucuguagcc caggcuggag                                                   20


<210>  6012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6012
aaaaaaaaaa aaaaguaaac                                                   20


<210>  6013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6013
uggccuccaa auuuaacaca                                                   20


<210>  6014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6014
uuuguaaaag uaacaaaaac                                                   20


<210>  6015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6015
aggacgguga agguugggca                                                   20


<210>  6016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6016
cagcacuuug ggaggcugag                                                   20


<210>  6017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6017
ccccgccuca gccucccaaa                                                   20


<210>  6018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6018
cuugagcuug agaccagccu                                                   20


<210>  6019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6019
ccacaaaaau aaaaaaauaa                                                   20


<210>  6020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6020
uggcucacua cagcuugacc                                                   20


<210>  6021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6021
ugccacugca cuccagccug                                                   20


<210>  6022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6022
cgcccaggcu ggagugcagu                                                   20


<210>  6023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6023
agaccauguc ucuagagaaa                                                   20


<210>  6024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6024
uaugacuuuc uuggguucac                                                   20


<210>  6025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6025
uucuucuugg aaaacacacu                                                   20


<210>  6026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6026
uuuguaauga gaaugcuuug                                                   20


<210>  6027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6027
ccuagaacua ggcuucuagc                                                   20


<210>  6028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6028
agccacauuu ugguuugccu                                                   20


<210>  6029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6029
acugcugaac aaucaagcca                                                   20


<210>  6030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6030
guuggaagcc cuugauauua                                                   20


<210>  6031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6031
agggcuucca acagaucaac                                                   20


<210>  6032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6032
ugacuccuaa gccgcuuaaa                                                   20


<210>  6033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6033
aagaccuaua gaaagagaug                                                   20


<210>  6034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6034
cuuucuauag gucuuugauc                                                   20


<210>  6035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6035
uucuaggauc cuuggcucuc                                                   20


<210>  6036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6036
uagaaggaug gcaucucuuu                                                   20


<210>  6037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6037
uuggcucucu ugggaacuag                                                   20


<210>  6038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6038
aguucccaag agagccaagg                                                   20


<210>  6039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6039
gaaucuaguu cccaagagag                                                   20


<210>  6040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6040
uggagugcaa uggugccauc                                                   20


<210>  6041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6041
cggcucaccg caaccucugc                                                   20


<210>  6042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6042
cagcuacucg ggaggcugag                                                   20


<210>  6043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6043
ccugagguca ggaguucgag                                                   20


<210>  6044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6044
acccgccucg gccucccaaa                                                   20


<210>  6045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6045
cagcacuuug ggaggccgag                                                   20


<210>  6046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6046
auguaugacu gaaacacuga                                                   20


<210>  6047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6047
gaaccgaaga cauuuucauu                                                   20


<210>  6048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6048
acuugccaaa uuaacuuggu                                                   20


<210>  6049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6049
cuaccaucua cuugccaaau                                                   20


<210>  6050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6050
ucaccuagca uuguugggau                                                   20


<210>  6051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6051
caacaaugcu aggugaagau                                                   20


<210>  6052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6052
ucugaaguug acagaccaaa                                                   20


<210>  6053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6053
gaaguugaca gaccaaaaua                                                   20


<210>  6054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6054
gaauuacaug uuuaguucua                                                   20


<210>  6055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6055
caucuuuauu acgguagagu                                                   20


<210>  6056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6056
uuauuacggu agaguuaaug                                                   20


<210>  6057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6057
cccauuaacu cuaccguaau                                                   20


<210>  6058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6058
ugacaaauua ugauguggug                                                   20


<210>  6059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6059
uaauuuguca ugauuuauag                                                   20


<210>  6060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6060
ccacaucaua auuugucaug                                                   20


<210>  6061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6061
cugcaacuga aagacuguug                                                   20


<210>  6062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6062
aguguuguaa uucugugguc                                                   20


<210>  6063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6063
cagcucugcu uucuucuuuu                                                   20


<210>  6064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6064
uuaaaauaaa auuuaaaaau                                                   20


<210>  6065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6065
aggcauguug guacaugccu                                                   20


<210>  6066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6066
ccugaagcua agaguuaaag                                                   20


<210>  6067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6067
uccugccucu gccucccaaa                                                   20


<210>  6068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6068
cugcuuccug uguuaguuuu                                                   20


<210>  6069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6069
ucggucaugu gaaaacagcc                                                   20


<210>  6070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6070
cauaggccua cuugaggggc                                                   20


<210>  6071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6071
auggaaugcu guccagucuc                                                   20


<210>  6072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6072
guuacugcau gugcuccucu                                                   20


<210>  6073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6073
cuugcagcag accaucaguu                                                   20


<210>  6074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6074
uuucuguuuu caguucuggu                                                   20


<210>  6075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6075
cuuuuuaagg caacuacuug                                                   20


<210>  6076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6076
caaaagcacc cugcucccau                                                   20


<210>  6077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6077
aagcuccuuu cucuuacugg                                                   20


<210>  6078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6078
aguaagagaa aggagcuuug                                                   20


<210>  6079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6079
uagaguaaaa gauagcauuu                                                   20


<210>  6080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6080
uuuacucuaa gauauguaug                                                   20


<210>  6081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6081
ucaaauggac caaggcugaa                                                   20


<210>  6082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6082
uggcucuugc cugcacggaa                                                   20


<210>  6083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6083
caagucuuga uauuuccuau                                                   20


<210>  6084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6084
agacuuguga uacugacgca                                                   20


<210>  6085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6085
ugccucugcc ugcccaccca                                                   20


<210>  6086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6086
ugccugccug ccuguacucu                                                   20


<210>  6087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6087
uggagaaagg ggccucuuca                                                   20


<210>  6088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6088
uuaaaaagaa acaagaaaau                                                   20


<210>  6089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6089
ucggauuaug cuucacugac                                                   20


<210>  6090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6090
gaagaucuuu aaaaagaaac                                                   20


<210>  6091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6091
uucauuaaca agccauauuu                                                   20


<210>  6092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6092
aaaccaacug guggcaaaau                                                   20


<210>  6093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6093
aauccaaacc aacugguggc                                                   20


<210>  6094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6094
cacaaaggca agacuagucc                                                   20


<210>  6095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6095
cucggacaug uagaaggaca                                                   20


<210>  6096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6096
cugugcagcu caaauguggu                                                   20


<210>  6097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6097
gcgcaauaag acagugacca                                                   20


<210>  6098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6098
cacaauugag gcaaaauauu                                                   20


<210>  6099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6099
ugucucugcu ggaaguccua                                                   20


<210>  6100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6100
gaccagccac auuucaggua                                                   20


<210>  6101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6101
aaucagacca gccacauuuc                                                   20


<210>  6102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6102
acacagagcu guuuaaauuu                                                   20


<210>  6103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6103
uuugaccuua uuuaaucugc                                                   20


<210>  6104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6104
gcccaacauu ugcaaguaag                                                   20


<210>  6105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6105
aauacaguaa uucugccacc                                                   20


<210>  6106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6106
ugaaaccaau caaauacagu                                                   20


<210>  6107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6107
cguguuuuua uauaaguaag                                                   20


<210>  6108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6108
caaagugguu ugccuauuuc                                                   20


<210>  6109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6109
aggauaagca gaauagccaa                                                   20


<210>  6110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6110
uagauggaau gugaaauagg                                                   20


<210>  6111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6111
uucuuggcua uucugcuuau                                                   20


<210>  6112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6112
cucucuuuug guccaagaua                                                   20


<210>  6113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6113
uggaccaaaa gagagggaug                                                   20


<210>  6114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6114
guuucuaaac cagucuaucu                                                   20


<210>  6115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6115
ucuguuucua aaccagucua                                                   20


<210>  6116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6116
gcuuuguuug uuguccaugu                                                   20


<210>  6117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6117
cggugagcaa agcuggaagg                                                   20


<210>  6118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6118
ugugcucuuc ccugccugcc                                                   20


<210>  6119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6119
agacuauacc cagucagggu                                                   20


<210>  6120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6120
ccaccaccca cgaccaggac                                                   20


<210>  6121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6121
ccucugccac agaggaaggg                                                   20


<210>  6122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6122
augucaacuu uauuacuaua                                                   20


<210>  6123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6123
caguuaauuc uuagaacugc                                                   20


<210>  6124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6124
uuuagaacuu aagcacaaag                                                   20


<210>  6125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6125
ugugccaaaa ccaagaauga                                                   20


<210>  6126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6126
aucuuucucu caucaggcca                                                   20


<210>  6127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6127
augggcaaga aagaaugcuu                                                   20


<210>  6128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6128
uucucucauc aggccacuuc                                                   20


<210>  6129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6129
ggccacuucu uggguugaua                                                   20


<210>  6130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6130
acccaagaag uggccugaug                                                   20


<210>  6131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6131
cuucuccacg ccacacagug                                                   20


<210>  6132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6132
agagcuccua gggcagaaac                                                   20


<210>  6133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6133
caauuccacc aucgagagcu                                                   20


<210>  6134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6134
caucccaauu ccaccaucga                                                   20


<210>  6135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6135
cacauccugc cuguuuugaa                                                   20


<210>  6136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6136
ugccuguuuu gaaaacagca                                                   20


<210>  6137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6137
gccuuccugc ccgccuccuu                                                   20


<210>  6138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6138
uggucuccgg gcacuugguc                                                   20


<210>  6139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6139
caaggguggc acaggggagc                                                   20


<210>  6140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6140
acaggcucug ccuucuuucu                                                   20


<210>  6141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6141
cuacucggga cccuaggaag                                                   20


<210>  6142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6142
ucucaucuca gccacguucu                                                   20


<210>  6143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6143
cagccacguu cucagugcca                                                   20


<210>  6144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6144
gugaaccaag aacacccuca                                                   20


<210>  6145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6145
ucugugucug guuggggaca                                                   20


<210>  6146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6146
aaggccacaa agccuucuuu                                                   20


<210>  6147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6147
gagaccacag ugcugcugcu                                                   20


<210>  6148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6148
ucacagaaaa cacaucagag                                                   20


<210>  6149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6149
ccuguuuuua uccucacaga                                                   20


<210>  6150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6150
uggaaucacc uguuuuuauc                                                   20


<210>  6151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6151
cauggugaca cccgccuggu                                                   20


<210>  6152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6152
gaauagcaaa agcuuuagaa                                                   20


<210>  6153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6153
cucucucugc ggagagcaag                                                   20


<210>  6154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6154
uucucaugag ccucugucca                                                   20


<210>  6155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6155
cagcggaaca ggggaccuuc                                                   20


<210>  6156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6156
uguccccaag uucauccuca                                                   20


<210>  6157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6157
ucauccuccu gccggcuucc                                                   20


<210>  6158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6158
uccugccggc uuccuggccc                                                   20


<210>  6159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6159
uucuggauuc ucuggaauug                                                   20


<210>  6160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6160
agaaggaugu ggcgucagga                                                   20


<210>  6161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6161
aaggcaaaau ucaauuccag                                                   20


<210>  6162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6162
auugcaggcc agguguggug                                                   20


<210>  6163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6163
ugugcacuuu gggaagccaa                                                   20


<210>  6164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6164
gcccaccuug gcuucccaaa                                                   20


<210>  6165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6165
caaacuccug ggcucaagca                                                   20


<210>  6166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6166
uguuucuaua gaaaauacaa                                                   20


<210>  6167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6167
uccugucuca gguuccugag                                                   20


<210>  6168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6168
auugagcccc ggaggccaaa                                                   20


<210>  6169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6169
cagcccacug uagcuuuggc                                                   20


<210>  6170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6170
ugccacugua cuccagucug                                                   20


<210>  6171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6171
auugcauacu ucaccguagc                                                   20


<210>  6172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6172
uaggcccucc agcuugauuc                                                   20


<210>  6173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6173
agcuggaggg ccuaggauga                                                   20


<210>  6174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6174
auuaaguggc uagacagaga                                                   20


<210>  6175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6175
ccuuugugac cuuggcuguu                                                   20


<210>  6176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6176
agcuucucga cacgggacuu                                                   20


<210>  6177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6177
aauuaacaag aagaggcccu                                                   20


<210>  6178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6178
uuagggaugu ucagaauccc                                                   20


<210>  6179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6179
cuaaugaucu aauuaacaag                                                   20


<210>  6180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6180
cagcaucaua guauguuccu                                                   20


<210>  6181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6181
uaguauguuc cuccucccgc                                                   20


<210>  6182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6182
acuaggaggu ggcccucaga                                                   20


<210>  6183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6183
uccaccugaa cuucccuaau                                                   20


<210>  6184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6184
guucgcaggg cuguaauaag                                                   20


<210>  6185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6185
uacaccuaag gaagcugagg                                                   20


<210>  6186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6186
aaggucaccc agguaguaga                                                   20


<210>  6187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6187
uggcucuacu gucuacuacc                                                   20


<210>  6188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6188
gaaccaggca gucugauuca                                                   20


<210>  6189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6189
gacugccugg uucagaucgu                                                   20


<210>  6190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6190
aagcuguguu cuagguggcu                                                   20


<210>  6191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6191
cgggucuguc ccugcacgug                                                   20


<210>  6192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6192
uccuugaagg cagugcaugc                                                   20


<210>  6193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6193
uucugugggg cccucuguuc                                                   20


<210>  6194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6194
caggaaaccu ggaggagcca                                                   20


<210>  6195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6195
ccaaagugaa aggguccuaa                                                   20


<210>  6196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6196
acacaucccc aaagugaaag                                                   20


<210>  6197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6197
caaaaaaaaa aaaaaaaaaa                                                   20


<210>  6198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6198
ugccacugca cucuagccug                                                   20


<210>  6199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6199
uggccacugc ugccccugcc                                                   20


<210>  6200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6200
cagguauuug ggaggcggga                                                   20


<210>  6201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6201
cuugagguca ggaguucgag                                                   20


<210>  6202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6202
gcccaccuug gccucccaaa                                                   20


<210>  6203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6203
cagcacuuug ggaggccaag                                                   20


<210>  6204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6204
gaaauaaaau uuugauccca                                                   20


<210>  6205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6205
aaauuuuauu ucugauuuaa                                                   20


<210>  6206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6206
caacagugau gccaggcagc                                                   20


<210>  6207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6207
cuguugggau caaaauuuua                                                   20


<210>  6208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6208
gggcugccug gcaucacugu                                                   20


<210>  6209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6209
gggggagagg guggccuugg                                                   20


<210>  6210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6210
aaaggagagg auagaaugaa                                                   20


<210>  6211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6211
ucuccuuugg auaaacaagg                                                   20


<210>  6212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6212
ugacuucauu cuauccucuc                                                   20


<210>  6213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6213
uucucagggc uccaggaauc                                                   20


<210>  6214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6214
agcugagugu guugcugagg                                                   20


<210>  6215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6215
ugggccuagg caggccaagc                                                   20


<210>  6216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6216
cugcacucgg gccacagcgg                                                   20


<210>  6217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6217
cacuuauuua auggacuggu                                                   20


<210>  6218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6218
cagcacuuug ggaggcugag                                                   20


<210>  6219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6219
acccgccuca gccucccaaa                                                   20


<210>  6220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6220
cgagcucagg aguucaagac                                                   20


<210>  6221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6221
uagcuacuug ggaggcugag                                                   20


<210>  6222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6222
uggcucacug caaacuccac                                                   20


<210>  6223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6223
caaaaaaaaa aaaaaaagua                                                   20


<210>  6224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6224
uacuuuuuuu uuuuuuuuug                                                   20


<210>  6225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6225
guuucugcuu agaaaaauca                                                   20


<210>  6226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6226
gaauuuucua aaugccaggu                                                   20


<210>  6227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6227
ucgcguagcc auguggcacu                                                   20


<210>  6228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6228
cgguccagug ccacauggcu                                                   20


<210>  6229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6229
cagcagcugc cacuaggcug                                                   20


<210>  6230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6230
cugcggaaca gccuaguggc                                                   20


<210>  6231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6231
uggaacgagc ccgcaaguuc                                                   20


<210>  6232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6232
ccacccaccc ggcccuggug                                                   20


<210>  6233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6233
gacaccagag cagcaccagg                                                   20


<210>  6234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6234
cauuuagaaa gcaacugcua                                                   20


<210>  6235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6235
ugugggauau gcuugucaug                                                   20


<210>  6236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6236
cacaagaugc aaugguguca                                                   20


<210>  6237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6237
uuagauaaug aaguaacagu                                                   20


<210>  6238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6238
aaggauaacc agaaccacau                                                   20


<210>  6239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6239
ucagcacagu auuucuggaa                                                   20


<210>  6240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6240
ugagccuucc agaaauacug                                                   20


<210>  6241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6241
cacgcugggg aaaagaaguu                                                   20


<210>  6242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6242
auacugagca gagaggcacg                                                   20


<210>  6243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6243
acucugugcc guauguagug                                                   20


<210>  6244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6244
accaagcauu ucaaaugucg                                                   20


<210>  6245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6245
uaacaggccu aagacaucca                                                   20


<210>  6246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6246
gcugcggauu cagcagauca                                                   20


<210>  6247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6247
gcagcugauu ucuaugcacg                                                   20


<210>  6248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6248
gcugaauccg cagcugauuu                                                   20


<210>  6249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6249
cuccuuuucu gacagauggg                                                   20


<210>  6250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6250
gucagaaaag gagugaucug                                                   20


<210>  6251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6251
gaguaagcag gcccaucugu                                                   20


<210>  6252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6252
gaaagcucug aaucugggaa                                                   20


<210>  6253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6253
gggaauugug uccccugaau                                                   20


<210>  6254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6254
aagcauuucu guuacuccaa                                                   20


<210>  6255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6255
ucuaagcauu ucuguuacuc                                                   20


<210>  6256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6256
gaggggguca cgaaacaguc                                                   20


<210>  6257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6257
aguuuuccuu uauaaccuuc                                                   20


<210>  6258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6258
ugaaauaaca uuaauagauu                                                   20


<210>  6259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6259
auuaauguua uuucaggaua                                                   20


<210>  6260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6260
cagcaccuug ggaagccaag                                                   20


<210>  6261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6261
gcccgccuug gcuucccaag                                                   20


<210>  6262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6262
ccugaggcca ggacuucgag                                                   20


<210>  6263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6263
uguuggccag gcuggucucg                                                   20


<210>  6264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6264
cuugaaccua ggaggaaaag                                                   20


<210>  6265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6265
cagcucacug caaccuuuuc                                                   20


<210>  6266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6266
cgccacugca cucuagccug                                                   20


<210>  6267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6267
caaaaaaaaa aaaaaaaaaa                                                   20


<210>  6268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6268
auuaauuuuu uuuuuuuuuu                                                   20


<210>  6269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6269
auggauuuuu aaccuaauaa                                                   20


<210>  6270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6270
auugauccau uaauuuuuuu                                                   20


<210>  6271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6271
uucuuuaaug guaauguaaa                                                   20


<210>  6272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6272
uaauuuuacc uuuacauuac                                                   20


<210>  6273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6273
ccauaagugu ccaagaugcc                                                   20


<210>  6274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6274
uggacacuua uggggauuua                                                   20


<210>  6275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6275
cccaccaccc acagcuggaa                                                   20


<210>  6276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6276
uuuuauuucc augagaugag                                                   20


<210>  6277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6277
cauggaaaua aaaagauacu                                                   20


<210>  6278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6278
aguugcagaa auuccugcug                                                   20


<210>  6279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6279
ccucucaggc uggcucccag                                                   20


<210>  6280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6280
gggagccagc cugagaggag                                                   20


<210>  6281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6281
uaaacccaca gugacagagu                                                   20


<210>  6282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6282
gucuuaccuc uuggugaacu                                                   20


<210>  6283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6283
uguguaccac aacacaccca                                                   20


<210>  6284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6284
uguucugagu cacccuagau                                                   20


<210>  6285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6285
agggugacuc agaacaagau                                                   20


<210>  6286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6286
caggccauac accgcccggu                                                   20


<210>  6287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6287
acuguaguca guaacagccc                                                   20


<210>  6288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6288
agauauagag gagugcuguc                                                   20


<210>  6289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6289
ugaugugguu gggggagggg                                                   20


<210>  6290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6290
ugccccuccc caggucuaac                                                   20


<210>  6291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6291
gugcucuguc ccucuguuca                                                   20


<210>  6292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6292
auaggcuagg ugugguggcu                                                   20


<210>  6293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6293
caguauuuug agaggcugaa                                                   20


<210>  6294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6294
ucccacuuca gccucucaaa                                                   20


<210>  6295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6295
ccagaaaaaa aaaauuuaaa                                                   20


<210>  6296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6296
cgucccugua guucagcugc                                                   20


<210>  6297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6297
uccugccuca gccucccaag                                                   20


<210>  6298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6298
cuugagcuca ggaguuagag                                                   20


<210>  6299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6299
uagcucacug uaaccucuaa                                                   20


<210>  6300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6300
ugccacugug cuccagccua                                                   20


<210>  6301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6301
guagaauuuu gguuuuuacc                                                   20


<210>  6302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6302
ugagggauua caggaaaagu                                                   20


<210>  6303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6303
cucaggauuu agaagagaac                                                   20


<210>  6304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6304
agcuaagaau auucugaaau                                                   20


<210>  6305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6305
uguuuaaaaa cacuucuucc                                                   20


<210>  6306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6306
acauguuuag aguggugaug                                                   20


<210>  6307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6307
ccacucuaaa cauguugaug                                                   20


<210>  6308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6308
gccgugaaag uugccaacug                                                   20


<210>  6309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6309
aacauagcca gugugaguuc                                                   20


<210>  6310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6310
gcaccuuuau uucagaacuc                                                   20


<210>  6311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6311
accauaaagc ugcacauuca                                                   20


<210>  6312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6312
auuccuaagc uacaauaaac                                                   20


<210>  6313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6313
gaauguugua uguguaauau                                                   20


<210>  6314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6314
ucuucaguau uuugcaaaua                                                   20


<210>  6315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6315
ucaguauuuu gcaaauaagc                                                   20


<210>  6316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6316
agaaacauug ucaaugcauc                                                   20


<210>  6317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6317
guugcuccuu cuagaagaca                                                   20


<210>  6318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6318
ggggacuaag uaacuuugug                                                   20


<210>  6319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6319
uccucuucuc cagacaucug                                                   20


<210>  6320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6320
cagaagagaa ugagagcccc                                                   20


<210>  6321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6321
uguguagaug acacuugcau                                                   20


<210>  6322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6322
acacaggaug uucuccuggu                                                   20


<210>  6323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6323
aaacuaaauc uagaaugaau                                                   20


<210>  6324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6324
agaaugaaug uuuacuucug                                                   20


<210>  6325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6325
agugacugga aggccaggcc                                                   20


<210>  6326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6326
aaugcccggc uauuggcuca                                                   20


<210>  6327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6327
uguaggcgug agccaauagc                                                   20


<210>  6328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6328
uuaguuauua uuauuccauu                                                   20


<210>  6329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6329
gaaccccacu acagucaaug                                                   20


<210>  6330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6330
uccuaccuca gccucucgag                                                   20


<210>  6331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6331
cuugagccca ggaguuugag                                                   20


<210>  6332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6332
cuaaaaaaau aaaaaauaaa                                                   20


<210>  6333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6333
aaguguggug gcucgugccu                                                   20


<210>  6334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6334
cagcucuuug agaagcugag                                                   20


<210>  6335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6335
uccgcccuca gcuucucaaa                                                   20


<210>  6336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6336
ucccuucuca gucucucagg                                                   20


<210>  6337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6337
aacaccuuuu cuacaaauua                                                   20


<210>  6338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6338
uaaaauguga caaagaacau                                                   20


<210>  6339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6339
aucauaaaau gugacaaaga                                                   20


<210>  6340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6340
cauauuuacc auggagaauu                                                   20


<210>  6341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6341
uacuacucag agauaacuug                                                   20


<210>  6342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6342
cugaguagua ugauuacagg                                                   20


<210>  6343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6343
aacagcaagu uaucucugag                                                   20


<210>  6344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6344
agaccaaaau cuaacagcaa                                                   20


<210>  6345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6345
uauagauacu acugucacau                                                   20


<210>  6346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6346
auaagauacc auguuuguga                                                   20


<210>  6347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6347
gaaaaggaag ccgacucucc                                                   20


<210>  6348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6348
uagagacuuu uucuggugau                                                   20


<210>  6349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6349
ccagaaaaag ucucuaggau                                                   20


<210>  6350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6350
uuaaaaguag aacaaaauag                                                   20


<210>  6351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6351
uuuuucuuau auuucuguga                                                   20


<210>  6352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6352
aacuuuauua acuuauaaaa                                                   20


<210>  6353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6353
ucccaaaucc aaaaaucuga                                                   20


<210>  6354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6354
caaauccaaa aaucugaaau                                                   20


<210>  6355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6355
aaaaaucuga aauccaaaau                                                   20


<210>  6356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6356
gaaauccaaa augcuccaaa                                                   20


<210>  6357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6357
aaaaugcucc aaauucugaa                                                   20


<210>  6358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6358
gaaaccuucc aaugaacauu                                                   20


<210>  6359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6359
gaaaaucuga aaccuuccaa                                                   20


<210>  6360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6360
uaaauucaga auacuucuga                                                   20


<210>  6361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6361
gaaguauucu gaauuuagga                                                   20


<210>  6362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6362
caaacauuuc agauaagggu                                                   20


<210>  6363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6363
gaaauguuug ggaucagaag                                                   20


<210>  6364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6364
gacaguacag guugaauaac                                                   20


<210>  6365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6365
ucugacagua cagguugaau                                                   20


<210>  6366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6366
caaaugaaaa auauuaaucg                                                   20


<210>  6367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6367
uuaaccaaau aucaaggaau                                                   20


<210>  6368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6368
aggaauugau cacauuuuac                                                   20


<210>  6369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6369
auuccuugau auuugguuaa                                                   20


<210>  6370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6370
cauuuuacag uuucugccua                                                   20


<210>  6371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6371
uaggcagaaa cuguaaaaug                                                   20


<210>  6372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6372
agaugaaaag gcucugcaug                                                   20


<210>  6373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6373
ugauucauaa uccuaggcag                                                   20


<210>  6374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6374
uaaauaucua cacuuaagau                                                   20


<210>  6375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6375
acacuuaaga uuuauuugau                                                   20


<210>  6376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6376
uaaguguaga uauuuaagau                                                   20


<210>  6377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6377
aauaaaucuu aaguguagau                                                   20


<210>  6378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6378
cacauaucaa auaaaucuua                                                   20


<210>  6379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6379
auucauauuu uggauucaac                                                   20


<210>  6380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6380
aaaauaugaa uggaucccac                                                   20


<210>  6381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6381
cugccacagu uuugacagaa                                                   20


<210>  6382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6382
ccuaucacug ccacaguuuu                                                   20


<210>  6383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6383
caaaauugga aaaagaguaa                                                   20


<210>  6384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6384
acagcacugc cugcccucuc                                                   20


<210>  6385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6385
cagcgcaacg cugccccugc                                                   20


<210>  6386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6386
gcagguagca ggggcagcgu                                                   20


<210>  6387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6387
cgcugaggcc ugccuuuguc                                                   20


<210>  6388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6388
aguuuccuac cuccucaauu                                                   20


<210>  6389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6389
caaauauaaa ccucacuaaa                                                   20


<210>  6390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6390
cucaucauau uuuuccuuag                                                   20


<210>  6391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6391
uauuuuuccu uagugucaga                                                   20


<210>  6392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6392
cauucaagau cugaucagcc                                                   20


<210>  6393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6393
ugaaugugau uuacaaugag                                                   20


<210>  6394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6394
gaucagccuu ucccacgagc                                                   20


<210>  6395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6395
gaucuugaau gugauuuaca                                                   20


<210>  6396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6396
gccuuuccca cgagccucca                                                   20


<210>  6397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6397
gugccguuca ucggaacucu                                                   20


<210>  6398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6398
gaacucugcu gccagcggcc                                                   20


<210>  6399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6399
aggcaauuca gucucguugu                                                   20


<210>  6400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6400
ugccgacuau ugccaguugc                                                   20


<210>  6401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6401
gaaauuaaag uuaaaaauuu                                                   20


<210>  6402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6402
uuuguucuuu uccuucuugc                                                   20


<210>  6403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6403
ccuccaagca cugaagaguu                                                   20


<210>  6404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6404
aucucagcca gucgggagcu                                                   20


<210>  6405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6405
cagccagucg ggagcugugc                                                   20


<210>  6406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6406
uugcuugucg ccggguagaa                                                   20


<210>  6407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6407
ggguuucucu ucccaauacc                                                   20


<210>  6408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6408
auaucagggu uucucuuccc                                                   20


<210>  6409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6409
gugaccaugu caagaccaua                                                   20


<210>  6410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6410
gcaaacuugc cguuacucgu                                                   20


<210>  6411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6411
gacacacgag uaacggcaag                                                   20


<210>  6412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6412
gacuguuucu uguauuuuuu                                                   20


<210>  6413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6413
uaguaagggc agacuagaaa                                                   20


<210>  6414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6414
guucauccuu uuuaaaugag                                                   20


<210>  6415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6415
uuuuuaaaug agcaugaggu                                                   20


<210>  6416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6416
aggaauaccu ucagagcagc                                                   20


<210>  6417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6417
uggguugucc uaacacaagg                                                   20


<210>  6418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6418
uuuauauccu ggguuguccu                                                   20


<210>  6419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6419
auauccuuua uauccugggu                                                   20


<210>  6420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6420
augugccuua uagguggguu                                                   20


<210>  6421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6421
auuucuuguc cugugaauuu                                                   20


<210>  6422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6422
gguuguuuua aaaguaggaa                                                   20


<210>  6423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6423
cacuuucuaa agaguaaagg                                                   20


<210>  6424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6424
uuuacucuuu agaaagugag                                                   20


<210>  6425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6425
ugccggucau ccuuuacucu                                                   20


<210>  6426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6426
cgucugugac gugaguggag                                                   20


<210>  6427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6427
caggacagug aauacaggca                                                   20


<210>  6428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6428
gguuuaucuu agcaaaauca                                                   20


<210>  6429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6429
uagcaaaauc aaagcauguc                                                   20


<210>  6430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6430
aagcauguca ucuaauugcu                                                   20


<210>  6431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6431
aauugcuaaa caagaguugg                                                   20


<210>  6432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6432
gagagacauu acucaauccu                                                   20


<210>  6433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6433
uuggcaugca ggacuuacau                                                   20


<210>  6434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6434
gcauccuguu gccauuuuau                                                   20


<210>  6435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6435
uguugccauu uuaugucuuc                                                   20


<210>  6436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6436
uuuaguugug uuugcaaagu                                                   20


<210>  6437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6437
cuacaucucc uaugugagug                                                   20


<210>  6438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6438
ccuaugugag uguauuucca                                                   20


<210>  6439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6439
cugcccccca ccccgccccg                                                   20


<210>  6440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6440
ugcuguguac uuugagcuga                                                   20


<210>  6441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6441
acaagguacu cuaaagacug                                                   20


<210>  6442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6442
cauuuaaaaa caccaucaac                                                   20


<210>  6443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6443
caaacugucc accuaauugu                                                   20


<210>  6444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6444
ucccaaacug uccaccuaau                                                   20


<210>  6445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6445
gcuaugagag ugacaacuuc                                                   20


<210>  6446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6446
cccgccaucu gcuaugagag                                                   20


<210>  6447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6447
ggacugaaga cuaagucuag                                                   20


<210>  6448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6448
cccucaucug gacugaagac                                                   20


<210>  6449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6449
uuuaaucucc cucaucugga                                                   20


<210>  6450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6450
ugugccagau gaggugauuu                                                   20


<210>  6451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6451
ggcacaagau auuuauaauc                                                   20


<210>  6452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6452
ccucaucugg cacaagauau                                                   20


<210>  6453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6453
guugucuuac ugggauauuu                                                   20


<210>  6454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6454
caguaagaca acugauagga                                                   20


<210>  6455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6455
aauaucccag uaagacaacu                                                   20


<210>  6456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6456
aagacucaaa ugcacaaauu                                                   20


<210>  6457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6457
ucuaagacuc aaaugcacaa                                                   20


<210>  6458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6458
guuuuacauu uauuaagaaa                                                   20


<210>  6459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6459
caguuuguac uccauuaaua                                                   20


<210>  6460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6460
ugaccuguuu gaguauugau                                                   20


<210>  6461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6461
auacucaaac aggucaugau                                                   20


<210>  6462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6462
ucucaucaau acucaaacag                                                   20


<210>  6463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6463
ccuuagagug uauauuucua                                                   20


<210>  6464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6464
uagugugcag aguuuagacu                                                   20


<210>  6465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6465
ccguccagcg ggugggaaga                                                   20


<210>  6466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6466
gccacaggug acagaggcac                                                   20


<210>  6467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6467
aggucugagg gagccaagca                                                   20


<210>  6468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6468
gcacugcuug gcucccucag                                                   20


<210>  6469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6469
aggaauaguc ggccguggcc                                                   20


<210>  6470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6470
ccucauaccu ucuggccacc                                                   20


<210>  6471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6471
aaauucauau ucauaagcug                                                   20


<210>  6472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6472
cuccccagca accagggcag                                                   20


<210>  6473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6473
ucuccugggu ugucugcuuu                                                   20


<210>  6474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6474
cuggagcuac aggccuaggc                                                   20


<210>  6475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6475
uguuccccuu auccauuuuu                                                   20


<210>  6476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6476
auuuuuuucu ucccaggacu                                                   20


<210>  6477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6477
ugucaaaucc caguguugga                                                   20


<210>  6478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6478
caguguugga ccaggucaga                                                   20


<210>  6479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6479
gaccuggucc aacacuggga                                                   20


<210>  6480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6480
gauuccugcu gaagauauga                                                   20


<210>  6481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6481
gauucaccag cucugcaccu                                                   20


<210>  6482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6482
ucagcaggaa uccgauucac                                                   20


<210>  6483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6483
ugaaggcauu cauaucuuca                                                   20


<210>  6484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6484
ucagcuuuuc uugugacuuc                                                   20


<210>  6485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6485
cacuuggaag ucacaagaaa                                                   20


<210>  6486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6486
ucaugugacc cacuuguuga                                                   20


<210>  6487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6487
ugugacccac uuguugacaa                                                   20


<210>  6488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6488
cgucccugcc cagacuggag                                                   20


<210>  6489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6489
gaaauggagu ccuccccacu                                                   20


<210>  6490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6490
gcauaacccc caugucccga                                                   20


<210>  6491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6491
agacagaaaa gcacauuguu                                                   20


<210>  6492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6492
acggaggugu uguuuugaaa                                                   20


<210>  6493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6493
agcuggcccc aaggcugggu                                                   20


<210>  6494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6494
caaaccauac acccagccuu                                                   20


<210>  6495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6495
ggccuccacu ggaggaacaa                                                   20


<210>  6496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6496
uguguuuguu ccuccagugg                                                   20


<210>  6497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6497
ucuaagcucc auggccaaga                                                   20


<210>  6498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6498
aagcuccaug gccaagacag                                                   20


<210>  6499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6499
acuuccaaga cacuagaaac                                                   20


<210>  6500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6500
uuagucguaa aagagacccu                                                   20


<210>  6501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6501
aagggucucu uuuacgacua                                                   20


<210>  6502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6502
cgcugcaucc aagggucucu                                                   20


<210>  6503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6503
aacagaggug ugaguagagg                                                   20


<210>  6504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6504
gggguugggg ggugaagaac                                                   20


<210>  6505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6505
acgcagggcu aaagcaccag                                                   20


<210>  6506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6506
gaacacacug uuguguugcc                                                   20


<210>  6507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6507
auuuacuaaa auuguuuauc                                                   20


<210>  6508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6508
uuuuuuuuuu uuuugagaca                                                   20


<210>  6509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6509
uggcucacug caaccuccgc                                                   20


<210>  6510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6510
uaugaaccca ggaggcggag                                                   20


<210>  6511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6511
cgucucuacu aaaaauacaa                                                   20


<210>  6512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6512
ccugagguca ggaguuugag                                                   20


<210>  6513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6513
gcccaccucg gccucccaaa                                                   20


<210>  6514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6514
cagcacuuug ggaggccgag                                                   20


<210>  6515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6515
uaagauucau gcagugaaag                                                   20


<210>  6516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6516
uaagauaaac aauuuuaggc                                                   20


<210>  6517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6517
cucaguaagu uagcuuucac                                                   20


<210>  6518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6518
cuaagcaaau uuaucacuca                                                   20


<210>  6519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6519
guuuauuagg uuuuccaaau                                                   20


<210>  6520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6520
ugaaugccaa aaguugaagc                                                   20


<210>  6521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6521
uaguuuaaua cucagaaaag                                                   20


<210>  6522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6522
aucuuaguuu aauacucaga                                                   20


<210>  6523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6523
uucagguaaa acaucuaucu                                                   20


<210>  6524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6524
gccaccaauc uuuaaauggc                                                   20


<210>  6525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6525
uuaaauggcu aaacaaaagg                                                   20


<210>  6526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6526
aaauugacau aagaaauacc                                                   20


<210>  6527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6527
uuuucaaacu uuaggguggu                                                   20


<210>  6528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6528
cugaggucuu ggaugacacu                                                   20


<210>  6529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6529
aagaccucag ugauacacca                                                   20


<210>  6530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6530
aagcuaaagu gucauccaag                                                   20


<210>  6531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6531
aagagcauaa aaaauuaaaa                                                   20


<210>  6532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6532
guucucucuu aguauuuuaa                                                   20


<210>  6533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6533
aaaauauuuu uaagaaaauu                                                   20


<210>  6534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6534
gguaagaaaa acacaacaga                                                   20


<210>  6535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6535
guuguuauug uuuguuaacc                                                   20


<210>  6536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6536
gagcauuaaa gguuaacaaa                                                   20


<210>  6537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6537
cuaggcuuaa gcauggagcu                                                   20


<210>  6538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6538
ugucuuccag cccgagcugc                                                   20


<210>  6539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6539
uucaacuugc uccaguaggc                                                   20


<210>  6540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6540
guuugguaau uaaaauuaaa                                                   20


<210>  6541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6541
uauuuuuaaa aagcauucca                                                   20


<210>  6542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6542
acugccuuua uuguacauuu                                                   20


<210>  6543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6543
aauacauuga aagcguuuac                                                   20


<210>  6544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6544
ccccugaggu cuggcccagc                                                   20


<210>  6545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6545
guccacagga cugcacgugg                                                   20


<210>  6546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6546
acacauccgu ccacaggacu                                                   20


<210>  6547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6547
gauucucaga gaauugcuug                                                   20


<210>  6548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6548
gaugaaagcu caagacauug                                                   20


<210>  6549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6549
acuucgaaag gcagucaagc                                                   20


<210>  6550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6550
gugcucacgu uugcacccac                                                   20


<210>  6551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6551
ccugaaacag aaggaccucg                                                   20


<210>  6552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6552
gucccugccc acucuggccc                                                   20


<210>  6553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6553
ugcuuuucaa auaaaacugc                                                   20


<210>  6554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6554
cugaccaguc cagucacuuu                                                   20


<210>  6555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6555
cagccuggca guaagucuug                                                   20


<210>  6556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6556
uucacccuca ccucgccacu                                                   20


<210>  6557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6557
gcaccuacca uguuaggugg                                                   20


<210>  6558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6558
accuaacaug guaggugcag                                                   20


<210>  6559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6559
uaauuuuaga gacaugaaaa                                                   20


<210>  6560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6560
ucuggaagua cuuuaugucu                                                   20


<210>  6561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6561
ggaaguacuu uaugucuuaa                                                   20


<210>  6562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6562
agaacgugua cacauucugg                                                   20


<210>  6563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6563
uuaaagggcc aucgcugugc                                                   20


<210>  6564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6564
cugugcugcc ugcccucagc                                                   20


<210>  6565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6565
gugccauuac ucacaaaaug                                                   20


<210>  6566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6566
uuuugugagu aauggcacug                                                   20


<210>  6567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6567
caaaccauau gacuccacgu                                                   20


<210>  6568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6568
cuguccuuca gguuucagcu                                                   20


<210>  6569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6569
cacgcugacu uucccacuuc                                                   20


<210>  6570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6570
cagcacaggg ugauugcugc                                                   20


<210>  6571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6571
cccugugcug ugaucacacg                                                   20


<210>  6572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6572
gcagcaauca cccugugcug                                                   20


<210>  6573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6573
ugcauacagc aggcacauaa                                                   20


<210>  6574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6574
uauuugacuc ucacaacccc                                                   20


<210>  6575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6575
cacagggggu ugugagaguc                                                   20


<210>  6576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6576
cuagaaccca cgcucucaaa                                                   20


<210>  6577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6577
cuccugggcu acguggccac                                                   20


<210>  6578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6578
caguugugga accguccaaa                                                   20


<210>  6579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6579
aaugccagga cagggccuaa                                                   20


<210>  6580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6580
augagcagau cccgcugagu                                                   20


<210>  6581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6581
gcucauggau caaaugccag                                                   20


<210>  6582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6582
cgcugagucu ggaucuccag                                                   20


<210>  6583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6583
agacucagcg ggaucugcuc                                                   20


<210>  6584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6584
ccaggcaggg cuggacugcu                                                   20


<210>  6585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6585
acugugugca cuucauccug                                                   20


<210>  6586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6586
uggaggccgg ugaguccccg                                                   20


<210>  6587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6587
uaguuccugu cugcuucacc                                                   20


<210>  6588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6588
ccaauuccua gcuuaguacc                                                   20


<210>  6589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6589
accucuccau ccccaauucc                                                   20


<210>  6590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6590
ggaagggcug ggccccaucu                                                   20


<210>  6591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6591
cuuacucucc aauauauugg                                                   20


<210>  6592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6592
aaauaaaaug acuaaaaaag                                                   20


<210>  6593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6593
aaaauaccuc uaaacuuuau                                                   20


<210>  6594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6594
cagagacaua aaguuuagag                                                   20


<210>  6595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6595
uuggucuuag cuguuuuaug                                                   20


<210>  6596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6596
uauaagacua aauacauaaa                                                   20


<210>  6597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6597
uaagauuaau aacauuacau                                                   20


<210>  6598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6598
uaugaucaua uaagacuaaa                                                   20


<210>  6599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6599
ucugaaugua auguuauuaa                                                   20


<210>  6600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6600
ucaacaaggg ucauuagcca                                                   20


<210>  6601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6601
cucuauaaca uuuaauuuaa                                                   20


<210>  6602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6602
gugcauuugu agccaacuug                                                   20


<210>  6603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6603
uuguuuucaa guuggcuaca                                                   20


<210>  6604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6604
agggauuacu acuuaaaagc                                                   20


<210>  6605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6605
cuggaucuuu guuuucaagu                                                   20


<210>  6606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6606
cuauaaccuc caagaagucu                                                   20


<210>  6607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6607
ucacuauaac cuccaagaag                                                   20


<210>  6608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6608
aaaucaucac uauaaccucc                                                   20


<210>  6609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6609
ugagccgucu cauaauaacc                                                   20


<210>  6610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6610
cucacccuga gguuauuaug                                                   20


<210>  6611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6611
gaaugaaauc ugaaguucaa                                                   20


<210>  6612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6612
gaaguucaaa ucuucagaca                                                   20


<210>  6613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6613
ucagacauau accacuaacc                                                   20


<210>  6614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6614
cuugguuagu gguauauguc                                                   20


<210>  6615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6615
aggcuagucu gucuaucccu                                                   20


<210>  6616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6616
cuuucaacuu uugugaggcu                                                   20


<210>  6617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6617
gugcuuuuua uucaacauuu                                                   20


<210>  6618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6618
gcgaggagga ggaggaagua                                                   20


<210>  6619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6619
acuuccuccu ccuccucgcu                                                   20


<210>  6620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6620
aaacacacag aguaagucuc                                                   20


<210>  6621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6621
uucacagaga cgugcaccgc                                                   20


<210>  6622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6622
guacacaugc ggcugucucu                                                   20


<210>  6623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6623
cagcuggucu guagggucag                                                   20


<210>  6624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6624
cagaauaacu gcagagugug                                                   20


<210>  6625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6625
uugagggcag ggaacagguu                                                   20


<210>  6626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6626
cucaacaaaa gguuguugcu                                                   20


<210>  6627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6627
guuuuggugg auauuuaaaa                                                   20


<210>  6628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6628
accaaaacag auggcugaac                                                   20


<210>  6629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6629
aaaucccagu gauuuaagcc                                                   20


<210>  6630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6630
cagugauuua agccaguuau                                                   20


<210>  6631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6631
cugggauuug gauuuuuuuu                                                   20


<210>  6632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6632
uccucccaac aggcacugcc                                                   20


<210>  6633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6633
ggcaucuuuu ccaugcucug                                                   20


<210>  6634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6634
uuuccaugcu cuguggcuca                                                   20


<210>  6635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6635
ugagugcacc agugcuuuug                                                   20


<210>  6636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6636
ugguugugga uggaguuuuc                                                   20


<210>  6637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6637
acaaccagga uugcacaaaa                                                   20


<210>  6638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6638
caaaccucug uggguccuuc                                                   20


<210>  6639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6639
caaacugaag ccugaaggac                                                   20


<210>  6640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6640
ugaaaucaca aacugaagcc                                                   20


<210>  6641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6641
uccagccgag uggcaccuca                                                   20


<210>  6642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6642
acagccugag gugccacucg                                                   20


<210>  6643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6643
ugugcuucug uggugaggau                                                   20


<210>  6644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6644
ucaccacaga agcacaggau                                                   20


<210>  6645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6645
acacgguugg cacuauucuu                                                   20


<210>  6646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6646
aucaguuaau cccuccaugu                                                   20


<210>  6647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6647
guuaaucccu ccauguaaag                                                   20


<210>  6648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6648
cuccauguaa agcaccugga                                                   20


<210>  6649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6649
guuccaggug cuuuacaugg                                                   20


<210>  6650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6650
ugauuuuuag uuagauuucc                                                   20


<210>  6651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6651
ugauagcauu uguugaguau                                                   20


<210>  6652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6652
aacuaaaaau caugauagca                                                   20


<210>  6653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6653
uggcgguuug aguuagagca                                                   20


<210>  6654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6654
ucacccaaac agaacccacu                                                   20


<210>  6655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6655
ucuucaccca aacagaaccc                                                   20


<210>  6656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6656
ccucgauagg acguuacuuc                                                   20


<210>  6657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6657
aggugauuaa aaaaacaaag                                                   20


<210>  6658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6658
aauaaauauu aauaggccgg                                                   20


<210>  6659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6659
cagcacuuug ggaggccgag                                                   20


<210>  6660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6660
gcccgccucg gccucccaaa                                                   20


<210>  6661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6661
cgaggucagg agaucgagac                                                   20


<210>  6662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6662
ccugaccucg ugauccgccc                                                   20


<210>  6663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6663
agaccauccc agcuaaaacg                                                   20


<210>  6664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6664
cagcuaaaac ggugaaaccc                                                   20


<210>  6665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6665
cggcucacug caagcuccgc                                                   20


<210>  6666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6666
cgccacugca cuccagccug                                                   20


<210>  6667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6667
uaggaaguug cccaaacugu                                                   20


<210>  6668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6668
cguggccugu ggguaauagc                                                   20


<210>  6669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6669
uauuuuagua gguaugauau                                                   20


<210>  6670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6670
uaccuacuaa aauaugauuu                                                   20


<210>  6671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6671
acagaauggu gucuugaguc                                                   20


<210>  6672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6672
ucccaagggu gugaaguguc                                                   20


<210>  6673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6673
uugcuucacu ggcuuuccua                                                   20


<210>  6674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6674
aagggccaug uugucauccu                                                   20


<210>  6675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6675
uguggcuccu cagccucaga                                                   20


<210>  6676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6676
cagagagugg gccagagggc                                                   20


<210>  6677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6677
cagcagaaaa uggggagaau                                                   20


<210>  6678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6678
gccuauacca uacaauucuc                                                   20


<210>  6679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6679
gcaggccuuc aguggccaac                                                   20


<210>  6680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6680
acuuagacuc ugaguuggcc                                                   20


<210>  6681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6681
uauaugccca guguagaaag                                                   20


<210>  6682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6682
aaacaagcaa cgguuaagag                                                   20


<210>  6683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6683
uaaguauauc acugcagccu                                                   20


<210>  6684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6684
cugcagccug ugagauggug                                                   20


<210>  6685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6685
cacaggcugc agugauauac                                                   20


<210>  6686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6686
ucaucagccu ggcccgccug                                                   20


<210>  6687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6687
ucagccuggc ccgccugccc                                                   20


<210>  6688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6688
gccuggcccg ccugccccuu                                                   20


<210>  6689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6689
ccgcagccca gaggcugccu                                                   20


<210>  6690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6690
cuaagagauu aguguuagac                                                   20


<210>  6691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6691
cuuagggaug uagggccuca                                                   20


<210>  6692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6692
ggucuaacac uaaucucuua                                                   20


<210>  6693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6693
cacucacucg agggggugug                                                   20


<210>  6694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6694
ccaaaggaaa aucucacuca                                                   20


<210>  6695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6695
cagcacuuug ggaagccaag                                                   20


<210>  6696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6696
gcccaccuug gcuucccaaa                                                   20


<210>  6697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6697
cuugagguca ggauuucgag                                                   20


<210>  6698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6698
ugaccucaag ugauccgccc                                                   20


<210>  6699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6699
cuacuaaaaa uauaaaaauu                                                   20


<210>  6700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6700
cagcuacuca ggagacugag                                                   20


<210>  6701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6701
cuugaaccca ggaggcgaag                                                   20


<210>  6702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6702
cggcuuacug caaccuucgc                                                   20


<210>  6703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6703
cgccacugca cucuagccug                                                   20


<210>  6704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6704
auaacaccua ccuuuuuuuu                                                   20


<210>  6705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6705
gaacccuugu uucagauaac                                                   20


<210>  6706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6706
gaaacaaggg uucugaucaa                                                   20


<210>  6707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6707
acccucacuc uccucaagcu                                                   20


<210>  6708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6708
ucucccacca gcccgcugaa                                                   20


<210>  6709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6709
cccaccagcc cgcugaaaua                                                   20


<210>  6710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6710
uauuucagcg ggcugguggg                                                   20


<210>  6711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6711
ucuuauuuca gcgggcuggu                                                   20


<210>  6712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6712
ucaggcagga aagaaaggcc                                                   20


<210>  6713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6713
aacaauacug cguccuugga                                                   20


<210>  6714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6714
ugagagauaa ggauucugcc                                                   20


<210>  6715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6715
cucaggauca aacaauacug                                                   20


<210>  6716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6716
uuaucucuca ggaucaaaca                                                   20


<210>  6717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6717
ggaauaccuu cauucccugc                                                   20


<210>  6718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6718
gguuaugaga caguaacugc                                                   20


<210>  6719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6719
ucaggugugc ucuggacggc                                                   20


<210>  6720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6720
ggaaggcagc uguaacaggc                                                   20


<210>  6721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6721
guuaugcucc ccuaugcucc                                                   20


<210>  6722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6722
cuuaccucac cacaggaaag                                                   20


<210>  6723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6723
uagagccccc ucugccuuug                                                   20


<210>  6724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6724
gcacaaaggc agagggggcu                                                   20


<210>  6725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6725
ugggguuccg uuggguccuu                                                   20


<210>  6726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6726
gcucacgguc uggccagcuc                                                   20


<210>  6727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6727
ugccacuuga acagcaucaa                                                   20


<210>  6728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6728
agccugccuc uggauucuuc                                                   20


<210>  6729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6729
agaggcaggc uugaugcugu                                                   20


<210>  6730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6730
gagcugaacc ucauugaacg                                                   20


<210>  6731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6731
ugaggcugcu ggcacacccc                                                   20


<210>  6732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6732
gcucugcccu cccacuuccu                                                   20


<210>  6733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6733
aguggcccuc ccaaaucugc                                                   20


<210>  6734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6734
gaguugaguc aggacagaca                                                   20


<210>  6735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6735
uccgaguuga gucaggacag                                                   20


<210>  6736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6736
ucucaggugu ggaagcuugg                                                   20


<210>  6737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6737
aagcuuccac accugagaag                                                   20


<210>  6738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6738
ccucccgguu ugggugacca                                                   20


<210>  6739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6739
cagggaaugc ugugccaaaa                                                   20


<210>  6740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6740
ccguggaguu ccuccaggaa                                                   20


<210>  6741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6741
accgcaucaa cacacuaggu                                                   20


<210>  6742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6742
acacacuagg uacucuuggg                                                   20


<210>  6743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6743
accgggagga aauccagagc                                                   20


<210>  6744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6744
agagccccca guacugggau                                                   20


<210>  6745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6745
caguacuggg ggcucuggau                                                   20


<210>  6746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6746
ucucauuuga cuccagaaaa                                                   20


<210>  6747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6747
uuucuggagu caaaugagaa                                                   20


<210>  6748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6748
ugcuuaaauc uuuucuggag                                                   20


<210>  6749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6749
auuuucucag uauaaaagga                                                   20


<210>  6750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6750
caguuccugu guuuuguggc                                                   20


<210>  6751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6751
cagcuuugug uauuccgggc                                                   20


<210>  6752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6752
aaggcagaau uuggucucac                                                   20


<210>  6753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6753
gacuggugaa cacaagaaaa                                                   20


<210>  6754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6754
uguugugucu caguggucca                                                   20


<210>  6755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6755
gcucccgucu gcuuguuccc                                                   20


<210>  6756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6756
gcaacaauuc uaugaaauag                                                   20


<210>  6757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6757
aauaggggca aaagugguga                                                   20


<210>  6758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6758
caccucuugc caucaaauag                                                   20


<210>  6759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6759
ugugguggga cuguaaucag                                                   20


<210>  6760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6760
gucaguucuc agugacugug                                                   20


<210>  6761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6761
gcagaagccc gagggacugg                                                   20


<210>  6762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6762
aaacaagccu caaaucugca                                                   20


<210>  6763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6763
cagaagguug uggcaggaga                                                   20


<210>  6764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6764
ucacagccag gaagaggagg                                                   20


<210>  6765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6765
guaucagugg ccuccugcuc                                                   20


<210>  6766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6766
guggccuccu gcucucuccc                                                   20


<210>  6767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6767
gacgugcgug acccaagacu                                                   20


<210>  6768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6768
gugucugaau caguccugca                                                   20


<210>  6769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6769
guccugcacg cucuccuucu                                                   20


<210>  6770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6770
cggggacccc gauguccauu                                                   20


<210>  6771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6771
ggguccccgu gauaaacggg                                                   20


<210>  6772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6772
cgucucucug gccuuaccac                                                   20


<210>  6773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6773
ugauggggac augaagcaca                                                   20


<210>  6774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6774
ugaugucuga ggcagccacg                                                   20


<210>  6775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6775
aacgaacagu uguuucugac                                                   20


<210>  6776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6776
auagggaugg agggucuguc                                                   20


<210>  6777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6777
cuauugauga gcugcauucg                                                   20


<210>  6778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6778
gacagacccu ccaucccuau                                                   20


<210>  6779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6779
ccguuccuac cuugauacac                                                   20


<210>  6780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6780
agguaggaac ggggauucag                                                   20


<210>  6781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6781
auucuucuag acaggucaga                                                   20


<210>  6782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6782
guaguaugug aauucuaccu                                                   20


<210>  6783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6783
acagaguugu gcagccagcu                                                   20


<210>  6784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6784
ucccuggagu ccagcccuga                                                   20


<210>  6785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6785
gcugcacugu ccgagacaca                                                   20


<210>  6786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6786
uugaggaaac cgaaguauag                                                   20


<210>  6787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6787
ccuccauuuc aucauugagg                                                   20


<210>  6788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6788
uagaacugug ugagguuuaa                                                   20


<210>  6789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6789
cgaggggcug cgucaccagg                                                   20


<210>  6790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6790
gucaagacac cauucagcua                                                   20


<210>  6791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6791
cagcccccag accucagcag                                                   20


<210>  6792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6792
uuaacaugga augcaccgua                                                   20


<210>  6793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6793
auacgauugu gcccuuucug                                                   20


<210>  6794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6794
uauugauccu uaacauggaa                                                   20


<210>  6795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6795
uuuaguuuau caauauucag                                                   20


<210>  6796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6796
auauucagag gaguguaggu                                                   20


<210>  6797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6797
cugcaagaca uuagaaaaau                                                   20


<210>  6798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6798
ggcuucuuga aguguucacg                                                   20


<210>  6799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6799
uguuagcgua auguacguga                                                   20


<210>  6800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6800
agggccugca uuccacaacu                                                   20


<210>  6801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6801
gaaucaaggg ccugcauucc                                                   20


<210>  6802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6802
agauugucuu uaaauucaug                                                   20


<210>  6803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6803
ugaugacuug ugacauaugu                                                   20


<210>  6804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6804
uugaauuccc ucauacauuu                                                   20


<210>  6805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6805
aggacuccuu ugggcacaaa                                                   20


<210>  6806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6806
gauuguuuca gggcccgugu                                                   20


<210>  6807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6807
gaugggcaaa agcccauuuu                                                   20


<210>  6808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6808
uuugguagca cuuaaggcuc                                                   20


<210>  6809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6809
ggguccucuc ugugucuucc                                                   20


<210>  6810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6810
acguccuggc cgugcaggcc                                                   20


<210>  6811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6811
ccucacuggu gcucagugca                                                   20


<210>  6812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6812
ccugcacagg ccacacggac                                                   20


<210>  6813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6813
uacaagugaa aaacaccaga                                                   20


<210>  6814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6814
gagggauugu ggagcaagag                                                   20


<210>  6815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6815
cucugauaau gcucagcuuc                                                   20


<210>  6816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6816
cuugcuccac aaucccucug                                                   20


<210>  6817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6817
uuuauaucag gcaugggauc                                                   20


<210>  6818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6818
ggcaugggau ccugucccuu                                                   20


<210>  6819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6819
caugccugau auaaaugaug                                                   20


<210>  6820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6820
ugucccuucu cugucuccgg                                                   20


<210>  6821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6821
cugguguggu gagcaugcca                                                   20


<210>  6822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6822
ggaaaugaau gagaagcauu                                                   20


<210>  6823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6823
ugcuggucuu acagcccgug                                                   20


<210>  6824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6824
acacaagcug aaucuccagc                                                   20


<210>  6825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6825
ccagcuuuuc cuaagaaacc                                                   20


<210>  6826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6826
caggcaucgg agcuugucac                                                   20


<210>  6827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6827
gagcuuguca ccugguuuaa                                                   20


<210>  6828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6828
ccacacaacu cucuucuuuu                                                   20


<210>  6829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6829
caaaucccca cacaacucuc                                                   20


<210>  6830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6830
cagagcucua cgcuaaaaua                                                   20


<210>  6831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6831
auggcccucc aagugcucag                                                   20


<210>  6832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6832
agccuucaag gagcucauaa                                                   20


<210>  6833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6833
acuugccucc uccaaagggg                                                   20


<210>  6834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6834
ggggucuggc agaggguuag                                                   20


<210>  6835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6835
ccccaauucc cgggcaccag                                                   20


<210>  6836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6836
ugcucccgcu ccugccggcu                                                   20


<210>  6837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6837
ggucagccug ggcaccgagg                                                   20


<210>  6838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6838
ggguccccca gagagcuugc                                                   20


<210>  6839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6839
ccaagaccca cagggcucug                                                   20


<210>  6840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6840
gcacaggggg gcagggccgc                                                   20


<210>  6841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6841
agacucaggg ugcugguguu                                                   20


<210>  6842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6842
gccacgagaa gcugcugcua                                                   20


<210>  6843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6843
guagcagcag cuucucgugg                                                   20


<210>  6844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6844
accccgagcg ggagcugggg                                                   20


<210>  6845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6845
guuuuauucc uaggucccgc                                                   20


<210>  6846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6846
cuacauguga ggucucuuaa                                                   20


<210>  6847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6847
cuaucgcuac augugagguc                                                   20


<210>  6848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6848
gaggaggaaa cagaagcaca                                                   20


<210>  6849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6849
cuucacuuau cugaggagga                                                   20


<210>  6850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6850
auaacauuuu aggaggcuga                                                   20


<210>  6851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6851
uggcucacug cagccucaac                                                   20


<210>  6852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6852
uaugcaaaug gcccuacguu                                                   20


<210>  6853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6853
ggaacccggu gagcgaaaga                                                   20


<210>  6854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6854
caggguuucu gcugugaagg                                                   20


<210>  6855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6855
gucaaaggug aaaggacaga                                                   20


<210>  6856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6856
ugggguggaa acaucuguca                                                   20


<210>  6857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6857
uauuggucau uuucacuuau                                                   20


<210>  6858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6858
ccccaacccc gcugcauuug                                                   20


<210>  6859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6859
uucaauguuu gcguuguguc                                                   20


<210>  6860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6860
caugacaguu gguuugcgga                                                   20


<210>  6861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6861
uacuggggcu gaaguacggu                                                   20


<210>  6862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6862
cagacagggc agggguggca                                                   20


<210>  6863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6863
aggggcuaaa caucccagac                                                   20


<210>  6864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6864
cuggcacuag ccccaacuca                                                   20


<210>  6865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6865
ucacuggcac uagccccaac                                                   20


<210>  6866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6866
cgcagccacc acgcagucag                                                   20


<210>  6867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6867
agagcgcggg ucacaaaggc                                                   20


<210>  6868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6868
cacguauugg uuccguguuu                                                   20


<210>  6869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6869
gaauggaguc cccaaaacac                                                   20


<210>  6870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6870
cuucguagag ccucuuucug                                                   20


<210>  6871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6871
ggggccaguc aaccccagga                                                   20


<210>  6872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6872
caccccugag ggaggaggaa                                                   20


<210>  6873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6873
gucauuugau uuguuugagg                                                   20


<210>  6874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6874
aaugacugau aagaaauuuc                                                   20


<210>  6875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6875
cauguacuug gaaaauaccc                                                   20


<210>  6876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6876
cgcauauucc acaggaaaca                                                   20


<210>  6877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6877
acuccuguuc gcaguuuuug                                                   20


<210>  6878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6878
agcggcugua caacucaagc                                                   20


<210>  6879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6879
ugccguccag cucagccagg                                                   20


<210>  6880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6880
ugaucaguga gguggucaga                                                   20


<210>  6881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6881
ggauggccgg gguccuccug                                                   20


<210>  6882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6882
gugagguggu cagauccgua                                                   20


<210>  6883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6883
gaccaccuca cugaucagga                                                   20


<210>  6884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6884
guaagugagc cuucccauuc                                                   20


<210>  6885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6885
agaacgcuac uacuggcaag                                                   20


<210>  6886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6886
aggcaacgca uccagaacgc                                                   20


<210>  6887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6887
cgcuguuaga auccaggcaa                                                   20


<210>  6888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6888
ccagcuucua guggucucag                                                   20


<210>  6889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6889
gcucaaacug guugcgcucg                                                   20


<210>  6890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6890
cgucuucuga agggugcacc                                                   20


<210>  6891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6891
ucgcucagua ccuggugccu                                                   20


<210>  6892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6892
caaggacggc agcugccuug                                                   20


<210>  6893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6893
gccuugggac cugguguugg                                                   20


<210>  6894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6894
gagaagcacu gcagcucacg                                                   20


<210>  6895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6895
cagugaccug ugaauggcac                                                   20


<210>  6896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6896
cugggcuuau gacaucauug                                                   20


<210>  6897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6897
uuguaguagc ccauccccac                                                   20


<210>  6898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6898
ccacagaacc acggugugug                                                   20


<210>  6899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6899
uagauggugg aaaugcuacu                                                   20


<210>  6900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6900
acgaugccuc agcgccacca                                                   20


<210>  6901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6901
gggugcuaua gucucuuuuu                                                   20


<210>  6902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6902
gcuggcaccu ugaccaugaa                                                   20


<210>  6903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6903
cacaccaaau cugcuggcac                                                   20


<210>  6904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6904
augaagcaga gagcagcccu                                                   20


<210>  6905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6905
ucuggcuggg uccucacggu                                                   20


<210>  6906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6906
acaagggcuc ucccaucaug                                                   20


<210>  6907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6907
ugaccucauc accucccaag                                                   20


<210>  6908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6908
ccucccaagg ccccaccuuc                                                   20


<210>  6909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6909
cuccugaaac uccuacacug                                                   20


<210>  6910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6910
cagcggucaa guguucaucc                                                   20


<210>  6911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6911
ucuugaguuc cuccuuauuc                                                   20


<210>  6912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6912
ggauucagcc agugcagcau                                                   20


<210>  6913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6913
ugauaaacca gaagcagaau                                                   20


<210>  6914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6914
ccacauggua uuugccaagu                                                   20


<210>  6915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6915
aucaccugca cacgugaaau                                                   20


<210>  6916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6916
ccugcacacg ugaaaucauu                                                   20


<210>  6917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6917
uugcccgugg gucccgacau                                                   20


<210>  6918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6918
ggcgaagcau auucaaggau                                                   20


<210>  6919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6919
uugaauaugc uucgccagau                                                   20


<210>  6920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6920
auuuuaugau agcaauggaa                                                   20


<210>  6921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6921
uaaaauggau uacuagguaa                                                   20


<210>  6922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6922
gggccugccu agcccgugcu                                                   20


<210>  6923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6923
uucaccguca ugacagcauu                                                   20


<210>  6924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6924
cuccagccgc uaacauuugc                                                   20


<210>  6925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6925
ucccuugugg guguccuuca                                                   20


<210>  6926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6926
cucuucacgg cgaacacccu                                                   20


<210>  6927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6927
ugugggcaac acccagaggg                                                   20


<210>  6928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6928
gggccugagc acaaaaccac                                                   20


<210>  6929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6929
cccuaggcaa guguugugcc                                                   20


<210>  6930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6930
guaaucaaau gagaaauaau                                                   20


<210>  6931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6931
aaugagaaau aaucauuuug                                                   20


<210>  6932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6932
uuuugaaaag cagauccuaa                                                   20


<210>  6933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6933
gcuuuucaaa augauuauuu                                                   20


<210>  6934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6934
uaaggcagga uggucaugga                                                   20


<210>  6935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6935
ugccuuagga ucugcuuuuc                                                   20


<210>  6936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6936
uccagaaagc augagugcac                                                   20


<210>  6937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6937
ucugugaagg uuuucagcgc                                                   20


<210>  6938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6938
agagcauguc guuuugaggu                                                   20


<210>  6939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6939
gugccacccg agagcagguc                                                   20


<210>  6940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6940
ggaccugcuc ucggguggca                                                   20


<210>  6941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6941
ccucacacgc acaacgccac                                                   20


<210>  6942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6942
caggaacaag gaccaaaaga                                                   20


<210>  6943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6943
uuccacaaaa acaagaggcc                                                   20


<210>  6944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6944
agcgcuccau gggaauucug                                                   20


<210>  6945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6945
gcucuuuaac agugaggaga                                                   20


<210>  6946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6946
accuaaacac uuagcccacg                                                   20


<210>  6947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6947
aaaaccuagc aggguuaaau                                                   20


<210>  6948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6948
gggaucccca agacuacccc                                                   20


<210>  6949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6949
cugauagugg uuucugucaa                                                   20


<210>  6950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6950
ccaagacuac cccaggcuuu                                                   20


<210>  6951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6951
uagcugagag ucuuucuaga                                                   20


<210>  6952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6952
gcaaagaaaa uuagcaaggg                                                   20


<210>  6953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6953
ccccaugggc cucugcccuu                                                   20


<210>  6954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6954
ucucccagcg gggucgugca                                                   20


<210>  6955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6955
ucacugagga ggggcucccu                                                   20


<210>  6956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6956
ugagaggccu gugugcaagg                                                   20


<210>  6957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6957
cggucaucag cgacuaucuc                                                   20


<210>  6958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6958
gcgacuaucu ccucuccaac                                                   20


<210>  6959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6959
ccucuccaac cugaaaggga                                                   20


<210>  6960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6960
cuuucagguu ggagaggaga                                                   20


<210>  6961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6961
cccagugagu gggagccugg                                                   20


<210>  6962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6962
cccucuccaa gugcccaggc                                                   20


<210>  6963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6963
ggccaggagc cugggcacuu                                                   20


<210>  6964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6964
gugggaaccc aggugggugc                                                   20


<210>  6965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6965
gcucucauuc ucugcuccca                                                   20


<210>  6966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6966
caguggaaac aagagggagg                                                   20


<210>  6967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6967
uaaagcugcu ggacggcagg                                                   20


<210>  6968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6968
cugugaagag cuugacuugc                                                   20


<210>  6969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6969
cugcuaaagc cucugcgacu                                                   20


<210>  6970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6970
gccacccaca ugggggaguu                                                   20


<210>  6971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6971
uugcuccuaa uucuugcccu                                                   20


<210>  6972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6972
cuggccauuc cucccagacc                                                   20


<210>  6973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6973
ccuuugacaa gugggcagga                                                   20


<210>  6974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6974
ugccagacgg ccaccggcau                                                   20


<210>  6975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6975
ggggccauug cccucaucca                                                   20


<210>  6976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6976
aggccagagu gucacaagcc                                                   20


<210>  6977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6977
uugcugggca gugggugcug                                                   20


<210>  6978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6978
cuggagccug gcauagggcc                                                   20


<210>  6979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6979
ggcacauaug uuggugcagu                                                   20


<210>  6980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6980
cgucacugca ccaacauaug                                                   20


<210>  6981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6981
caaacgcaac uccuggacca                                                   20


<210>  6982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6982
agguagaaau ggugcguggg                                                   20


<210>  6983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6983
gucaccacgu ggucccaccu                                                   20


<210>  6984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6984
cugggcacgu uuuugugggu                                                   20


<210>  6985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6985
uauuggcucc ucuguucaca                                                   20


<210>  6986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6986
cccgacagcg ccggccuucc                                                   20


<210>  6987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6987
cagaaggcag cacgucauga                                                   20


<210>  6988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6988
ugacgugcug ccuucuguga                                                   20


<210>  6989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6989
agggccucgu ugagggacag                                                   20


<210>  6990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6990
aacguggaga gggcuucaca                                                   20


<210>  6991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6991
aggcucagcc acccccaucc                                                   20


<210>  6992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6992
ucuggacgua gggccggaau                                                   20


<210>  6993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6993
auaauacagg ugagugggcc                                                   20


<210>  6994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6994
ugcaaggaaa agagaaggga                                                   20


<210>  6995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6995
uaccaguggg ccaguuuuga                                                   20


<210>  6996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6996
cugcacaguc ucagguguuc                                                   20


<210>  6997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6997
gcacagggag aaaggccucu                                                   20


<210>  6998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6998
ccccacacau cugcacaggg                                                   20


<210>  6999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  6999
uuuaccacug ugcccucaga                                                   20


<210>  7000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7000
aggcgggaga gcugcucaga                                                   20


<210>  7001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7001
cuggucaagc ugagugugga                                                   20


<210>  7002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7002
ggcccagagc cgccauggcc                                                   20


<210>  7003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7003
gagggcaccu agucgagguc                                                   20


<210>  7004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7004
ccuugcaaga aaggcucugg                                                   20


<210>  7005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7005
cauguggcug agcugggcug                                                   20


<210>  7006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7006
gccccuugcu ugcccaggac                                                   20


<210>  7007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7007
ccugcuuuca gaucuccagg                                                   20


<210>  7008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7008
gaaagcaggu gauaucagcc                                                   20


<210>  7009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7009
ccagggacuc acuggacccc                                                   20


<210>  7010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7010
ugcagccccc gacagcgagu                                                   20


<210>  7011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7011
cugacucgcu gucgggggcu                                                   20


<210>  7012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7012
guucuuuuug auagguaaga                                                   20


<210>  7013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7013
aaaagaacag auacccgcuc                                                   20


<210>  7014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7014
cucagccguu agcuucccua                                                   20


<210>  7015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7015
gcagacacac acaaaagcac                                                   20


<210>  7016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7016
ccuggcgcug uugcuggagu                                                   20


<210>  7017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7017
cuggcaggac uccagcaaca                                                   20


<210>  7018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7018
cuccugaggg cucagggaca                                                   20


<210>  7019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7019
ugagagggga gcccacgggg                                                   20


<210>  7020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7020
uccugccgcu gcuccucacc                                                   20


<210>  7021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7021
uugagacccg uguggucagu                                                   20


<210>  7022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7022
ggggcccuug uccuugagaa                                                   20


<210>  7023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7023
accaugucgc caggacugag                                                   20


<210>  7024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7024
ggagccuugu ugcacugccu                                                   20


<210>  7025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7025
ggguggccag uggggagcca                                                   20


<210>  7026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7026
ggucaaacag uggagcaagg                                                   20


<210>  7027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7027
acaugaaaac agaccagcac                                                   20


<210>  7028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7028
caaaaagaaa agaaaaaaaa                                                   20


<210>  7029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7029
caccauugca cuccagccug                                                   20


<210>  7030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7030
cggcucacug caaccuccgc                                                   20


<210>  7031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7031
cuugaacccg ggaggcggag                                                   20


<210>  7032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7032
cagcuacuag ggaggcugag                                                   20


<210>  7033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7033
cuugaguuca ggaguucgag                                                   20


<210>  7034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7034
acccuccuug gccucccaaa                                                   20


<210>  7035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7035
cagcacuuug ggaggccaag                                                   20


<210>  7036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7036
acaugggggc cgggcgcagu                                                   20


<210>  7037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7037
uucuucaguc cccauaugcu                                                   20


<210>  7038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7038
guggucagcu gcgaggugcc                                                   20


<210>  7039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7039
gugcacacau gccagccgug                                                   20


<210>  7040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7040
cguucccguc ucaucagugc                                                   20


<210>  7041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7041
cuuucagugc ugaaaagcaa                                                   20


<210>  7042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7042
ugaaacacgc ccccugagca                                                   20


<210>  7043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7043
gguuagggaa gaagcagcga                                                   20


<210>  7044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7044
gugcucucgc ugcuucuucc                                                   20


<210>  7045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7045
cuauguguuc uaacgcuucg                                                   20


<210>  7046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7046
uaacaaaaga acccguuccc                                                   20


<210>  7047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7047
cuuuuguaac auccuucccg                                                   20


<210>  7048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7048
uucccgcugc gccguuucug                                                   20


<210>  7049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7049
gggcugggag ggacccucgg                                                   20


<210>  7050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7050
gcauuuuccc caguauuaga                                                   20


<210>  7051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7051
ugggaggagg gacgcagguc                                                   20


<210>  7052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7052
ggaaaggcuu uccuugugaa                                                   20


<210>  7053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7053
uggccaccac ucuggcuuca                                                   20


<210>  7054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7054
ugccccaguu ucuagacgac                                                   20


<210>  7055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7055
ugaacaaagu caucggagag                                                   20


<210>  7056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7056
gagaguuucu guccaaccag                                                   20


<210>  7057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7057
cacaugcaac cucaccuuau                                                   20


<210>  7058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7058
ccaucccaca ugcaaccuca                                                   20


<210>  7059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7059
gcugggaagu cggaggcaac                                                   20


<210>  7060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7060
ccgcgaccca cgggcuggug                                                   20


<210>  7061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7061
ucucuggguc ccuggugcug                                                   20


<210>  7062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7062
ugaaacauga gccucggugu                                                   20


<210>  7063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7063
gugggguuuu ugcaaagguu                                                   20


<210>  7064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7064
aggcacaaug accaaagcua                                                   20


<210>  7065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7065
cccucucggg gaaaggcuua                                                   20


<210>  7066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7066
uuacuuaagc cuuuccccga                                                   20


<210>  7067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7067
aguucccacc cccagaugcu                                                   20


<210>  7068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7068
ggggguggga acuggaucuu                                                   20


<210>  7069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7069
agccagccaa ggguugcagg                                                   20


<210>  7070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7070
gcgccuccac cuccauuccu                                                   20


<210>  7071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7071
agguggcccu uccggggcuc                                                   20


<210>  7072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7072
gcaggauggg caagcuggag                                                   20


<210>  7073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7073
ugcugaugac augugggagg                                                   20


<210>  7074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7074
ggugucugua gaagucugug                                                   20


<210>  7075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7075
ccggcugcug acuuguuuac                                                   20


<210>  7076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7076
ggagaaagga ccuggucacc                                                   20


<210>  7077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7077
gggccagaag uccucccucc                                                   20


<210>  7078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7078
agacacgggg cguggcaugc                                                   20


<210>  7079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7079
gugcauccag acacggggcg                                                   20


<210>  7080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7080
ugagaagaaa agagagaagg                                                   20


<210>  7081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7081
guaaagagau uaauuuuaac                                                   20


<210>  7082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7082
cuuuacugau auaauuaaau                                                   20


<210>  7083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7083
caaggccugu gcugcaugcg                                                   20


<210>  7084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7084
cagucaccuu gugaaugcau                                                   20


<210>  7085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7085
uaggggugcg cucaccugca                                                   20


<210>  7086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7086
auggagcagc aggucccaac                                                   20


<210>  7087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7087
cuucugcccc cguuccagcu                                                   20


<210>  7088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7088
ugcacgguga ccccuuuuag                                                   20


<210>  7089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7089
gcacucuccu gacuaaaagg                                                   20


<210>  7090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7090
gugcucaucg gagacugccc                                                   20


<210>  7091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7091
gagacugccc cacggcccug                                                   20


<210>  7092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7092
ccaggccagg ucccuggacc                                                   20


<210>  7093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7093
acuuccauuu uaaugacuug                                                   20


<210>  7094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7094
agaauccacu uccauuuuaa                                                   20


<210>  7095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7095
gcagcagccc ggccauccag                                                   20


<210>  7096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7096
agcuccuaca ucagcagcag                                                   20


<210>  7097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7097
acgggcauga ccaaaccaag                                                   20


<210>  7098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7098
cagcugcucc ccagcugcca                                                   20


<210>  7099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7099
gaccccuuuc uaccgcuccu                                                   20


<210>  7100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7100
ccauuccgua uugguugggg                                                   20


<210>  7101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7101
uagcuuuuuc cuggaaagcc                                                   20


<210>  7102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7102
caggccagau guuguuccug                                                   20


<210>  7103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7103
ggccugugau acugcugucu                                                   20


<210>  7104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7104
agccaggaac aacaucuggc                                                   20


<210>  7105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7105
cugggcucaa cauagaguuu                                                   20


<210>  7106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7106
cgucguaaac aagaggaaga                                                   20


<210>  7107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7107
aaaccagucc uuagcaaggg                                                   20


<210>  7108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7108
ccggagcaca caggcagguc                                                   20


<210>  7109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7109
augcaugugc auauagacac                                                   20


<210>  7110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7110
auaauuuuac acacacaccu                                                   20


<210>  7111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7111
ccgucuugag aggugugugu                                                   20


<210>  7112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7112
aggcguggga cguggucagg                                                   20


<210>  7113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7113
uagugggcaa ugaaugagcc                                                   20


<210>  7114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7114
cacuggcgaa gauggucucc                                                   20


<210>  7115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7115
ucgccagugg gauccuagug                                                   20


<210>  7116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7116
gcucucugca gaagggagga                                                   20


<210>  7117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7117
uguuccuaaa aaucuguggc                                                   20


<210>  7118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7118
guggcaagca cccaucguau                                                   20


<210>  7119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7119
uauuauccaa auuuuguugc                                                   20


<210>  7120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7120
aaauuuuguu gcaaauguga                                                   20


<210>  7121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7121
cauuugcaac aaaauuugga                                                   20


<210>  7122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7122
ccccacagcc cacccccaaa                                                   20


<210>  7123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7123
ggaaagauuu uaaugaaacc                                                   20


<210>  7124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7124
uucccgauau uaccagcagg                                                   20


<210>  7125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7125
ccuacauaga cucagcuggg                                                   20


<210>  7126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7126
gagaaggccc ugugcccuaa                                                   20


<210>  7127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7127
ucauggaggg ggucauuuca                                                   20


<210>  7128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7128
cagcuccaag aggaggagcu                                                   20


<210>  7129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7129
gucccgagcu ccacgugggg                                                   20


<210>  7130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7130
uucccagcag acauccucau                                                   20


<210>  7131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7131
ucaucgggcu uugucccucc                                                   20


<210>  7132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7132
ggcuuugucc cucccccgcu                                                   20


<210>  7133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7133
uccuucuucu cacuccuaca                                                   20


<210>  7134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7134
ugagagcugc ugagggaccu                                                   20


<210>  7135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7135
ugagcucucc aaggucccuc                                                   20


<210>  7136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7136
gggugguaac ugccagccuu                                                   20


<210>  7137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7137
uccaaggcug gcaguuacca                                                   20


<210>  7138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7138
uggccaacgu ggaccugccu                                                   20


<210>  7139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7139
cagcccugcu ggcuccaggg                                                   20


<210>  7140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7140
cucgucaguc cuucccuuug                                                   20


<210>  7141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7141
aaauuaaagg aaaaaaaugg                                                   20


<210>  7142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7142
guuguugcug ugugaggcuu                                                   20


<210>  7143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7143
ggcauuaugg aggguccccc                                                   20


<210>  7144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7144
cuggcuacag aaaacacggg                                                   20


<210>  7145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7145
gcagggcagg aagaccaccu                                                   20


<210>  7146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7146
uaagcuuaua ugacauacac                                                   20


<210>  7147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7147
ggcccagcac agagacuaga                                                   20


<210>  7148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7148
caccucuggu guggccgggg                                                   20


<210>  7149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7149
ccgcugggcu gagcagaggc                                                   20


<210>  7150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7150
ccaaggcuuc cgagaggcuc                                                   20


<210>  7151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7151
ugggaugcag augucuuacc                                                   20


<210>  7152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7152
caagaugacu acaccaccaa                                                   20


<210>  7153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7153
gcaucccaag augacuacac                                                   20


<210>  7154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7154
cugcucagag aaagggggcc                                                   20


<210>  7155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7155
cuaucccugc ucagagaaag                                                   20


<210>  7156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7156
gucugccgga gggauguggu                                                   20


<210>  7157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7157
cuccggcaga cugaucccua                                                   20


<210>  7158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7158
gucuccucau aggugacacc                                                   20


<210>  7159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7159
gagagcacac ccuguccccu                                                   20


<210>  7160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7160
aauaccaccg aaggcacagg                                                   20


<210>  7161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7161
caacaaagcc aguagcagcc                                                   20


<210>  7162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7162
ggaagucgcu uccccugcgu                                                   20


<210>  7163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7163
gacuuacagu gcuccacgca                                                   20


<210>  7164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7164
uguagaggca aggccccccu                                                   20


<210>  7165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7165
uccgcgagcc cacgagucug                                                   20


<210>  7166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7166
ccaggaccuc uuuugggaaa                                                   20


<210>  7167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7167
cuugcggguc ccccaggcuc                                                   20


<210>  7168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7168
ucuggggggg cccgccagug                                                   20


<210>  7169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7169
cuggaggcag agggcugaag                                                   20


<210>  7170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7170
accucaggac cagccugucc                                                   20


<210>  7171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7171
uggccccugu acccucugga                                                   20


<210>  7172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7172
uuccccuccu ggccccaauu                                                   20


<210>  7173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7173
cggggggccc cugggcaggc                                                   20


<210>  7174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7174
ccacccaucu gcacaggcug                                                   20


<210>  7175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7175
gcacaggcug ugcucaccac                                                   20


<210>  7176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7176
acccagaaau gcugagcagg                                                   20


<210>  7177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7177
ugcucagcau uucugggugg                                                   20


<210>  7178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7178
cuucuaaaua augaggcugg                                                   20


<210>  7179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7179
guccccugcu ggggaggggc                                                   20


<210>  7180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7180
gcugccugcc ugguucuugu                                                   20


<210>  7181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7181
uccaggcagc auucccaggg                                                   20


<210>  7182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7182
accuuggagc ugcuggggac                                                   20


<210>  7183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7183
cccagcaugg ugcuggcuaa                                                   20


<210>  7184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7184
gacuauauca cccagcaugg                                                   20


<210>  7185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7185
uguuaccccu guuguggagg                                                   20


<210>  7186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7186
cccggcacaa gggguaagca                                                   20


<210>  7187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7187
cuuggcaucu cccggcacaa                                                   20


<210>  7188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7188
gcaggcacuc cacagagcuc                                                   20


<210>  7189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7189
ccacucgacu aaggucagcc                                                   20


<210>  7190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7190
cuacugccug gcacuggggc                                                   20


<210>  7191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7191
ucccuacugc cuggcacugg                                                   20


<210>  7192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7192
gggccucagg agacaucauc                                                   20


<210>  7193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7193
gccccaugag acuaguccag                                                   20


<210>  7194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7194
cuggggcccu ccccauacac                                                   20


<210>  7195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7195
ugacugcggg caagagggag                                                   20


<210>  7196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7196
cggccucugc ccgcugcccc                                                   20


<210>  7197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7197
gcacccgaaa cguaacacau                                                   20


<210>  7198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7198
ggggcucucg gcaggcugug                                                   20


<210>  7199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7199
cagucccuca gccccacagg                                                   20


<210>  7200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7200
ggcugcccau cagcucccug                                                   20


<210>  7201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7201
gcucccugcg uacccagacu                                                   20


<210>  7202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7202
gcccagcaag ccagggggag                                                   20


<210>  7203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7203
cugcuguccu caccggccgg                                                   20


<210>  7204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7204
gcccccaguu cagugccgcc                                                   20


<210>  7205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7205
gccugggcgg cggugagagg                                                   20


<210>  7206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7206
auauugcggc gagcgggcca                                                   20


<210>  7207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7207
gggcugcacu gacgggccau                                                   20


<210>  7208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7208
aaaugacguu ucccguuuaa                                                   20


<210>  7209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7209
gacaggcagg aauuuaguua                                                   20


<210>  7210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7210
cggcguccgu ccaguugcgg                                                   20


<210>  7211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7211
ucucguacac cuuggcguug                                                   20


<210>  7212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7212
cgaagagcuu gcuggccauc                                                   20


<210>  7213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7213
ccucgcccag ccugcgcucg                                                   20


<210>  7214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7214
agaucaagau caccaacaug                                                   20


<210>  7215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7215
ugaucuccuc gcccagccug                                                   20


<210>  7216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7216
agaucaccaa caugaccuuc                                                   20


<210>  7217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7217
ugaucuugau cuccucgccc                                                   20


<210>  7218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7218
ccaacaugac cuuccaguac                                                   20


<210>  7219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7219
ucccgacuca gagcuccaag                                                   20


<210>  7220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7220
uggccucugc ccagcaccag                                                   20


<210>  7221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7221
acugagccuc ugccaugagc                                                   20


<210>  7222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7222
ccaggugagg ugcaggacca                                                   20


<210>  7223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7223
cccuggcugg gugguccccu                                                   20


<210>  7224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7224
uaaagugcgu ggguccccag                                                   20


<210>  7225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7225
ccccacaccu gugaccuuca                                                   20


<210>  7226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7226
uggaagcuga caggcucucc                                                   20


<210>  7227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7227
acgcaacuga aagcggagac                                                   20


<210>  7228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7228
aaucaacgca acugaaagcg                                                   20


<210>  7229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7229
gucaugcuca gcacccuagg                                                   20


<210>  7230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7230
ucagagguuc gguggacaca                                                   20


<210>  7231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7231
cucagccucc aggaauggag                                                   20


<210>  7232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7232
gccaugacgu gcagugcacc                                                   20


<210>  7233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7233
agucacccag ccacagcuuc                                                   20


<210>  7234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7234
uuguccuuuu ucuuuauacc                                                   20


<210>  7235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7235
cuaaccucug ccccaggcuu                                                   20


<210>  7236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7236
ccugcucacc aucuggcugu                                                   20


<210>  7237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7237
ggcugugccu guuugcuggg                                                   20


<210>  7238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7238
agcuuauugu uuccaacggc                                                   20


<210>  7239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7239
cugccucacu ggacccagua                                                   20


<210>  7240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7240
ggcagugugg gaaggggccc                                                   20


<210>  7241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7241
ggcccacccc agggccucug                                                   20


<210>  7242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7242
agcgcuacaa ccugcaaccu                                                   20


<210>  7243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7243
aggcuccugc ccagacugua                                                   20


<210>  7244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7244
gcccuguagc ugggggaggg                                                   20


<210>  7245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7245
aaguaagccc cucccccagc                                                   20


<210>  7246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7246
ucacuauguc auugauauaa                                                   20


<210>  7247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7247
cuaugucauu gauauaaaaa                                                   20


<210>  7248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7248
augacauagu gaugaucaaa                                                   20


<210>  7249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7249
ccacacuuug cugugugacu                                                   20


<210>  7250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7250
caucuccaca cuuugcugug                                                   20


<210>  7251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7251
cuauauuuau auaucuuaua                                                   20


<210>  7252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7252
uauaauaccu uauuauuaca                                                   20


<210>  7253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7253
gugcaugcug ggaccuuggg                                                   20


<210>  7254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7254
gagcccgugu agguccugaa                                                   20


<210>  7255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7255
ugacccugga gccuggccga                                                   20


<210>  7256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7256
gccaggcucc agggucaaga                                                   20


<210>  7257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7257
gucaugcauu uuaauuuccu                                                   20


<210>  7258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7258
auggcuaggu aauagggcca                                                   20


<210>  7259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7259
caucaauggc uagguaauag                                                   20


<210>  7260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7260
caggacucgg ggaccuuggc                                                   20


<210>  7261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7261
ucgaagcggc cuucguagga                                                   20


<210>  7262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7262
uccucgaagc ggccuucgua                                                   20


<210>  7263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7263
cuccgacagc uccuccagcu                                                   20


<210>  7264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7264
cagcccccac cauuuagaga                                                   20


<210>  7265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7265
cuuuugagcu gcacggaaag                                                   20


<210>  7266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7266
guaccuuucu cagagggugg                                                   20


<210>  7267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7267
caggagagaa gacgcagcau                                                   20


<210>  7268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7268
cguguugccg ugggcaugac                                                   20


<210>  7269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7269
aucccacacc ucagacccgu                                                   20


<210>  7270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7270
cacaccucag acccgucccg                                                   20


<210>  7271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7271
ugcaggcaca gucacguggc                                                   20


<210>  7272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7272
uccuguucuu gccuccaaau                                                   20


<210>  7273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7273
acaaucuucc uguucuugcc                                                   20


<210>  7274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7274
uuaguagaga aggcgucucc                                                   20


<210>  7275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7275
ugagucaagc agcggccccc                                                   20


<210>  7276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7276
caggccuccu gcugguuccu                                                   20


<210>  7277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7277
gggagggcag cccccacgcc                                                   20


<210>  7278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7278
ggcccaaagc gcggaucuca                                                   20


<210>  7279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7279
gcgcuuuggg ccugaucagg                                                   20


<210>  7280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7280
cacgccccug agguuggcug                                                   20


<210>  7281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7281
cuggcccaca cucugcucug                                                   20


<210>  7282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7282
cccggcggcc uagaaauggg                                                   20


<210>  7283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7283
caggcccuuc cuucugggac                                                   20


<210>  7284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7284
gccuaaggcc ggguggggcu                                                   20


<210>  7285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7285
cucccugggg guggucucuc                                                   20


<210>  7286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7286
ugccagggag cacccuucac                                                   20


<210>  7287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7287
cacccuuucc agaccgaagg                                                   20


<210>  7288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7288
acaccccuuc ggucuggaaa                                                   20


<210>  7289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7289
gcuagucgca aaggacggca                                                   20


<210>  7290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7290
cgccacugcu cucugcacaa                                                   20


<210>  7291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7291
uggcucacug caaccuccgc                                                   20


<210>  7292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7292
cuugaaccca cgaggcggag                                                   20


<210>  7293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7293
cagcuacucg ggaggcugag                                                   20


<210>  7294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7294
cuacuaaaaa uacaaaaauu                                                   20


<210>  7295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7295
ccugagguca ggaguucaag                                                   20


<210>  7296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7296
accugccucu gccucccaaa                                                   20


<210>  7297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7297
cagcacuuug ggaggcagag                                                   20


<210>  7298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7298
uacugggcaa auggggaaac                                                   20


<210>  7299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7299
ugcaggugca gagccugcag                                                   20


<210>  7300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7300
ugcgcuccug cagcugcagg                                                   20


<210>  7301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7301
ucuccagcag acucaucaug                                                   20


<210>  7302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7302
ucaccaaguc cagcgucuag                                                   20


<210>  7303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7303
ccaaguccag cgucuaggcc                                                   20


<210>  7304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7304
ugccagaggc cagguggaag                                                   20


<210>  7305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7305
augauacuug acguggcuuu                                                   20


<210>  7306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7306
uugauaguaa cgacacugga                                                   20


<210>  7307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7307
aagccacguc aaguaucauu                                                   20


<210>  7308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7308
ucaccaagcc agcaacagca                                                   20


<210>  7309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7309
gggcauccuc accaagccag                                                   20


<210>  7310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7310
aucagggcau ccucaccaag                                                   20


<210>  7311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7311
aucaaucagg gcauccucac                                                   20


<210>  7312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7312
cgaaaaugaa agcagaugga                                                   20


<210>  7313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7313
gcuuucauuu ucgggaucca                                                   20


<210>  7314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7314
ggcgucagag gccauuuaag                                                   20


<210>  7315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7315
gguguuucca cugccuccuu                                                   20


<210>  7316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7316
ccagcaccca gaacacucaa                                                   20


<210>  7317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7317
ugguggauga cacaaaggcc                                                   20


<210>  7318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7318
accaugauau cuccagcacc                                                   20


<210>  7319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7319
caaccugcaa ccauuucucu                                                   20


<210>  7320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7320
gugggggaca gagggguggu                                                   20


<210>  7321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7321
cccucuggcu gccaagcgag                                                   20


<210>  7322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7322
ugccaggcag ugcugcaguc                                                   20


<210>  7323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7323
ugcgacaagc agcagcagcu                                                   20


<210>  7324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7324
uacccucuag ggggucuuga                                                   20


<210>  7325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7325
ugcuugccca gcuccccuuu                                                   20


<210>  7326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7326
ccccagagcc ugugugccga                                                   20


<210>  7327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7327
cacagcaaca ugggccgagu                                                   20


<210>  7328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7328
ggcagcugga aacuggcacc                                                   20


<210>  7329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7329
cuucucaacc acagggucag                                                   20


<210>  7330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7330
ucuguccucc uggggccacc                                                   20


<210>  7331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7331
gaugcgggcc ugaguuuugg                                                   20


<210>  7332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7332
gaugugcccg cauccucugu                                                   20


<210>  7333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7333
uuugcuuaac aaacacacug                                                   20


<210>  7334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7334
aggguggcac agguguccag                                                   20


<210>  7335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7335
guuaugucuu gugggagcgu                                                   20


<210>  7336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7336
uuuagaaccu ccaucuguua                                                   20


<210>  7337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7337
gggacagcac accgcgaguc                                                   20


<210>  7338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7338
gagucaguga uucaugcccu                                                   20


<210>  7339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7339
cugacucuga uuagagaggg                                                   20


<210>  7340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7340
ccuuagagaa ggggcaggcg                                                   20


<210>  7341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7341
ccucauguca gcagaacuca                                                   20


<210>  7342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7342
ugggguuggu gccuuucauc                                                   20


<210>  7343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7343
gcagcauguc cuuaacaacu                                                   20


<210>  7344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7344
gaaaguuguu aaggacaugc                                                   20


<210>  7345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7345
uuuuuuuucu ccuuaaugga                                                   20


<210>  7346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7346
cagccauugc uaaaauauuu                                                   20


<210>  7347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7347
aauauuuuag caauggcuga                                                   20


<210>  7348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7348
uaucaaauau uuuagcaaug                                                   20


<210>  7349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7349
ggagccaggc agaugugcuu                                                   20


<210>  7350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7350
gccuggcucc ugauucuagu                                                   20


<210>  7351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7351
uaaugcauua gcuaaaaacg                                                   20


<210>  7352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7352
cagcacuuug ggaggcugag                                                   20


<210>  7353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7353
ucccgccuca gccucccaaa                                                   20


<210>  7354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7354
ucugagguca ggaguucaag                                                   20


<210>  7355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7355
cagcuacuug ggaggcugag                                                   20


<210>  7356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7356
cuugaacccg ggaggcggag                                                   20


<210>  7357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7357
cagcucacug caaccuccgc                                                   20


<210>  7358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7358
uuuuuuaauu uuuuuuuuuu                                                   20


<210>  7359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7359
ugcuuauuuu auuuaucuuu                                                   20


<210>  7360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7360
gaaaacaaag guaacucuac                                                   20


<210>  7361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7361
ucauuuucaa caaguuuaag                                                   20


<210>  7362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7362
cauucagagu uggaaugaau                                                   20


<210>  7363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7363
aaauaauacc ugagcgcugg                                                   20


<210>  7364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7364
uuuuauuaau gucauuccaa                                                   20


<210>  7365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7365
cuucuugguu uugacaugga                                                   20


<210>  7366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7366
cguccauguc aaaaccaaga                                                   20


<210>  7367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7367
ucgcguccau gucaaaacca                                                   20


<210>  7368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7368
cagucugcgg uuccaacucc                                                   20


<210>  7369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7369
uguggcugcu ggaggccagg                                                   20


<210>  7370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7370
caccagcaac gcaggagucu                                                   20


<210>  7371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7371
uuaaaagugg gccaggugcg                                                   20


<210>  7372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7372
cagcacuuug ggaggccaag                                                   20


<210>  7373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7373
gccugucuug gccucccaaa                                                   20


<210>  7374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7374
cgaggucagg acauugagau                                                   20


<210>  7375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7375
caauguccug accucgugau                                                   20


<210>  7376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7376
uccuggcuaa cacggugaaa                                                   20


<210>  7377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7377
uggcuaacac ggugaaaccc                                                   20


<210>  7378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7378
cagcucacug caagcuccac                                                   20


<210>  7379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7379
cuccacugca cuccagccug                                                   20


<210>  7380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7380
uauuagaaau uaaaccugag                                                   20


<210>  7381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7381
cuggcuuaag agaagcccac                                                   20


<210>  7382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7382
ggguaagaau gagcuucucc                                                   20


<210>  7383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7383
guauauucuu ccgugauccu                                                   20


<210>  7384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7384
cggaagaaua uaccgauuau                                                   20


<210>  7385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7385
uauuccaaca cuggacaggu                                                   20


<210>  7386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7386
cgccacugca cuccagccug                                                   20


<210>  7387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7387
cuacuaaaaa uacaaaaaau                                                   20


<210>  7388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7388
uggcuaacac agugaaaccc                                                   20


<210>  7389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7389
ccugacaucg ugauccaccc                                                   20


<210>  7390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7390
ugauccaccc gccucggccu                                                   20


<210>  7391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7391
cgaugucagg agauugagac                                                   20


<210>  7392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7392
acccgccucg gccucccaaa                                                   20


<210>  7393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7393
gauacccuau caaugaacuu                                                   20


<210>  7394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7394
gauuccacac acaaccggcc                                                   20


<210>  7395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7395
augaacuucu acuucauuuc                                                   20


<210>  7396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7396
auugguccgu cuugugcuuc                                                   20


<210>  7397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7397
ugccuuugug accucacacg                                                   20


<210>  7398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7398
gcauaacuua gugaaccaaa                                                   20


<210>  7399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7399
guauuuuaaa aucacuuuug                                                   20


<210>  7400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7400
cuuuuggcga uaucaccaau                                                   20


<210>  7401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7401
ccaaaaguga uuuuaaaaua                                                   20


<210>  7402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7402
ccaaucuuag aaaagucuuu                                                   20


<210>  7403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7403
uagaaaaguc uuucaguugg                                                   20


<210>  7404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7404
gaauucugaa agacaccacc                                                   20


<210>  7405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7405
uugguaacaa augcugucag                                                   20


<210>  7406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7406
uuuuuuugag uaaaaagugu                                                   20


<210>  7407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7407
ggaacacacg uauggagcac                                                   20


<210>  7408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7408
agacggcagc ucagcccauu                                                   20


<210>  7409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7409
uuucaacguc cugcccgagc                                                   20


<210>  7410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7410
cggacauuug gaagugaccg                                                   20


<210>  7411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7411
gugcgcaugu cagcuccgug                                                   20


<210>  7412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7412
cggggucuuc acggggucuu                                                   20


<210>  7413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7413
ucagacuaug augaaagcag                                                   20


<210>  7414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7414
gacuaugaug aaagcagcug                                                   20


<210>  7415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7415
uagucugaug aucacggggu                                                   20


<210>  7416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7416
ccagugagcc agcucugggu                                                   20


<210>  7417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7417
cagacagcgu gugggaaccg                                                   20


<210>  7418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7418
ccagugccua caagacagca                                                   20


<210>  7419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7419
gcuuuccacc ugacccuauc                                                   20


<210>  7420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7420
uugucuuuac aggguuucga                                                   20


<210>  7421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7421
cccuacagcc uuauuucccu                                                   20


<210>  7422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7422
gcucacauga cauuuuuuga                                                   20


<210>  7423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7423
uggccuaggg gaggauagaa                                                   20


<210>  7424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7424
uccccuaggc caggaugccu                                                   20


<210>  7425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7425
ccaggacuca gaacaugcga                                                   20


<210>  7426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7426
cagcuggguc cggagggaga                                                   20


<210>  7427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7427
uacaguagaa aaagccaguu                                                   20


<210>  7428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7428
gugagggaca ugaccagcca                                                   20


<210>  7429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7429
guggcuugug cagggaccac                                                   20


<210>  7430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7430
ccgccuugcu gggcacuagc                                                   20


<210>  7431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7431
gcucuccugc ucugcaccac                                                   20


<210>  7432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7432
aaaugaggcc caaguguggc                                                   20


<210>  7433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7433
gggaaaacau ccaaaugagg                                                   20


<210>  7434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7434
uuuuuccagg uagcccacag                                                   20


<210>  7435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7435
ccucugccca gcacgcccgg                                                   20


<210>  7436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7436
gacucaggcu gagaggugca                                                   20


<210>  7437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7437
cacagagacu gugugagcug                                                   20


<210>  7438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7438
ggcaggcugg caugagcuga                                                   20


<210>  7439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7439
gccgcuaaga accagcgcug                                                   20


<210>  7440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7440
gauuccagug uguggaggca                                                   20


<210>  7441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7441
gauucucccg uucaagagga                                                   20


<210>  7442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7442
cguggguccc uuacugaugg                                                   20


<210>  7443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7443
guaagggacc cacgagauga                                                   20


<210>  7444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7444
gcugcaccac gguuuauugc                                                   20


<210>  7445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7445
uucaaaacuc acuaguguac                                                   20


<210>  7446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7446
caacccgacc ucacguguaa                                                   20


<210>  7447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7447
guguggaaaa aaguaaaucu                                                   20


<210>  7448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7448
cguuguuaca gcaccguuug                                                   20


<210>  7449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7449
ucaagaaaga guccaaagcc                                                   20


<210>  7450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7450
aucuucaaga aagaguccaa                                                   20


<210>  7451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7451
acaggccauc caucuucaag                                                   20


<210>  7452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7452
aagccuuaau accaaaaccc                                                   20


<210>  7453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7453
gguuuuggua uuaaggcuuu                                                   20


<210>  7454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7454
ggccuguuuu guacuucuaa                                                   20


<210>  7455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7455
gccaggaccc acacuuccaa                                                   20


<210>  7456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7456
ccaccugugu gcuucuagag                                                   20


<210>  7457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7457
gucugcucua gaagcacaca                                                   20


<210>  7458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7458
ccgcugccuc accucugacc                                                   20


<210>  7459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7459
guggccucug ccaaccaugg                                                   20


<210>  7460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7460
cugucuugcu ucuccugacc                                                   20


<210>  7461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7461
cgcaggugcc gguuugucgg                                                   20


<210>  7462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7462
cugcagcugg cugccccggc                                                   20


<210>  7463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7463
agcaaucuua ucuaggagcc                                                   20


<210>  7464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7464
uaucuaggag ccugcagggu                                                   20


<210>  7465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7465
aggagccugc agggucccau                                                   20


<210>  7466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7466
cacuugucuc augggacccu                                                   20


<210>  7467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7467
ggcaaacugc cuuaaagggg                                                   20


<210>  7468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7468
gccuucuagg gcccugaggc                                                   20


<210>  7469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7469
gccuuccagc cugcagcagg                                                   20


<210>  7470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7470
ccuucuuggg gaacuuugcu                                                   20


<210>  7471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7471
caccggcuuu cauagcaccc                                                   20


<210>  7472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7472
ggggccccgu ggagccuggu                                                   20


<210>  7473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7473
ggggacuguc cagucaccgg                                                   20


<210>  7474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7474
gaccccaucc ugccuucaag                                                   20


<210>  7475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7475
ugccuucaag ccagcguaga                                                   20


<210>  7476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7476
acgcuggcuu gaaggcagga                                                   20


<210>  7477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7477
ggucugggua cacugggccu                                                   20


<210>  7478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7478
uccccuccuu gagggccaac                                                   20


<210>  7479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7479
acaaccaaug ccaggcuccc                                                   20


<210>  7480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7480
uggcagcacg ggugaguaag                                                   20


<210>  7481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7481
ucagcucagg gcgggugggg                                                   20


<210>  7482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7482
aaauuccgag cgugaauggg                                                   20


<210>  7483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7483
ugugcaauua ucauuaaauu                                                   20


<210>  7484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7484
uuaaauuaca gggacaauuu                                                   20


<210>  7485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7485
ugaaauuaaa auugucccug                                                   20


<210>  7486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7486
acugccgcuc agccuucgaa                                                   20


<210>  7487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7487
ccuuauugau uucuaucccc                                                   20


<210>  7488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7488
auaaggugau uuaaaauuua                                                   20


<210>  7489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7489
ccaaaaaagc cugcugaaau                                                   20


<210>  7490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7490
caauacaaau uucagcaggc                                                   20


<210>  7491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7491
cuaugucuuu uauuucucuu                                                   20


<210>  7492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7492
agagaaaaag aaauuacagc                                                   20


<210>  7493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7493
aaaccugaca aggacaucaa                                                   20


<210>  7494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7494
gaguuacaug gguuucauac                                                   20


<210>  7495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7495
uucucuuuuu ucugaaaaaa                                                   20


<210>  7496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7496
uuacacaauu uuuuucagaa                                                   20


<210>  7497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7497
cugaaacaga aaacagccaa                                                   20


<210>  7498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7498
gagcuuccac auuaagaagc                                                   20


<210>  7499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7499
uuuauuucaa acuaguuuuu                                                   20


<210>  7500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7500
aaauuuguag uauauaacua                                                   20


<210>  7501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7501
caaagaaaac uagaaaauua                                                   20


<210>  7502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7502
uguuugaccu gaguuauuua                                                   20


<210>  7503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7503
cauuaaaugc uaaaggacug                                                   20


<210>  7504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7504
acuauagaau aaauacucuu                                                   20


<210>  7505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7505
aaccuaauua acacauauag                                                   20


<210>  7506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7506
uuuauguucu uuuuuuuuuu                                                   20


<210>  7507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7507
guaagaacau aaggccgggu                                                   20


<210>  7508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7508
gaaauaagac cauaccauau                                                   20


<210>  7509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7509
acuuugaaau cauauuauac                                                   20


<210>  7510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7510
uauuauacua uuugauauau                                                   20


<210>  7511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7511
aauaguauaa uaugauuuca                                                   20


<210>  7512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7512
accagcaaug gauuccugca                                                   20


<210>  7513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7513
auugcuggua gaugcacacu                                                   20


<210>  7514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7514
gaaaacaccu uuauuuugcu                                                   20


<210>  7515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7515
uuaaaaaaug aaagcaaaau                                                   20


<210>  7516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7516
ccaaagcuca auaaauccca                                                   20


<210>  7517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7517
augagugauu uuuuuaaauu                                                   20


<210>  7518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7518
cucauagauc cccaaagcuc                                                   20


<210>  7519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7519
aaagaaacug uggccaaaau                                                   20


<210>  7520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7520
gaaauaaaac auguauuggu                                                   20


<210>  7521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7521
ugguaucuga aauaaaacau                                                   20


<210>  7522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7522
caaauagaaa uaugaagaaa                                                   20


<210>  7523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7523
uguagugacu gcucugcuca                                                   20


<210>  7524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7524
uuuaaaaaua aaaaaaacua                                                   20


<210>  7525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7525
cagccuccac agccuccccu                                                   20


<210>  7526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7526
caauggguaa gggaagagga                                                   20


<210>  7527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7527
ucaggguauu ccaaagcaca                                                   20


<210>  7528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7528
aacauaaucc ucaggguauu                                                   20


<210>  7529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7529
ucccaaagau gggacaucuu                                                   20


<210>  7530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7530
uugggaagau gcagaaacua                                                   20


<210>  7531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7531
ugacucaaug uguaucauau                                                   20


<210>  7532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7532
uauuugaccu uauaaucacc                                                   20


<210>  7533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7533
cccucagaac cacaaaagaa                                                   20


<210>  7534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7534
aauugcuuua acagcauuua                                                   20


<210>  7535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7535
ugaauacugu auaaauucaa                                                   20


<210>  7536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7536
aaugacuaga acagagcaug                                                   20


<210>  7537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7537
aaacauuuua aacauaaaau                                                   20


<210>  7538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7538
aaagaaauca gaacaaagaa                                                   20


<210>  7539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7539
gaacaaagaa augaaaacau                                                   20


<210>  7540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7540
uuaaagauua uuuacaugug                                                   20


<210>  7541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7541
guauagaauc auuaaagauu                                                   20


<210>  7542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7542
aaaauggcag aaaauaaucu                                                   20


<210>  7543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7543
caauugaaga gagaugugaa                                                   20


<210>  7544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7544
cucuucaauu gagauuauuc                                                   20


<210>  7545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7545
cucaguuuau ucacaucucu                                                   20


<210>  7546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7546
cagcacuggc aaauuugaaa                                                   20


<210>  7547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7547
agguguugcu uuaagagaug                                                   20


<210>  7548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7548
cuuaaagcaa caccuagauu                                                   20


<210>  7549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7549
ugcuauacau cacagugauu                                                   20


<210>  7550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7550
cagugauuuu ugugaugaaa                                                   20


<210>  7551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7551
cugugaugua uagcaagauu                                                   20


<210>  7552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7552
caaaaaucac ugugauguau                                                   20


<210>  7553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7553
acccaccugg gccucccaaa                                                   20


<210>  7554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7554
cuugagggua ggaguuccaa                                                   20


<210>  7555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7555
ugggggagac agaguuuggg                                                   20


<210>  7556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7556
caaacucugu cucccccacg                                                   20


<210>  7557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7557
acacuucuca gauaaagaua                                                   20


<210>  7558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7558
gagaaguguu gauuuucuuc                                                   20


<210>  7559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7559
uuaucugaga aguguugauu                                                   20


<210>  7560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7560
acuucuaagc cuaugcagug                                                   20


<210>  7561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7561
aauccacuuc uaagccuaug                                                   20


<210>  7562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7562
gugaauuuga agauacagca                                                   20


<210>  7563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7563
ucaaauucac ugauuuucuu                                                   20


<210>  7564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7564
ggauaaaaau gauugcagca                                                   20


<210>  7565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7565
agaugcuuca gacugggcca                                                   20


<210>  7566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7566
uuuuuaucca gaugcuucag                                                   20


<210>  7567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7567
uguggcagac ugcaugugga                                                   20


<210>  7568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7568
gucaccuuua uuucuucaac                                                   20


<210>  7569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7569
aagaaaucca acaaacccca                                                   20


<210>  7570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7570
aacaaacccc acacaggauu                                                   20


<210>  7571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7571
uguguggggu uuguuggauu                                                   20


<210>  7572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7572
cacccagaaa caucauagcc                                                   20


<210>  7573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7573
ugaaaauagc cagaaacaau                                                   20


<210>  7574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7574
uuguucuuuu cauguaaggu                                                   20


<210>  7575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7575
gaaauaauag uggucagagg                                                   20


<210>  7576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7576
cacuggccaa agccaaccag                                                   20


<210>  7577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7577
cugcuggugu aucccacugg                                                   20


<210>  7578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7578
gacuccagag agagcacagc                                                   20


<210>  7579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7579
gcugggcugg cugaagccca                                                   20


<210>  7580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7580
ugcuggcgcu ucccauuggc                                                   20


<210>  7581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7581
gugugugcug gcugcucagc                                                   20


<210>  7582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7582
ggcggggcgc auggcucaug                                                   20


<210>  7583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7583
caacacucag gaggcugagg                                                   20


<210>  7584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7584
uccuaccuca gccuccugag                                                   20


<210>  7585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7585
cagcucacug cagccucaac                                                   20


<210>  7586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7586
cacugcuaca cucuagccug                                                   20


<210>  7587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7587
caaaaaaaaa aaaaaaaaaa                                                   20


<210>  7588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7588
gcucacugau ggugaauucc                                                   20


<210>  7589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7589
gugagcagau gaaauaaauu                                                   20


<210>  7590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7590
cauaguauau uuauauauuu                                                   20


<210>  7591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7591
gaugcuuuga uauauguuua                                                   20


<210>  7592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7592
gauuguacaa uuuuucauuu                                                   20


<210>  7593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7593
aagcaucaga uuguacaauu                                                   20


<210>  7594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7594
uccagagcag cgccaagcca                                                   20


<210>  7595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7595
gcgcauaggc aggagccaag                                                   20


<210>  7596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7596
caaaaaaaaa aaaaaaagag                                                   20


<210>  7597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7597
cggcucacag caaccuccgc                                                   20


<210>  7598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7598
aguguagaca gagaggggac                                                   20


<210>  7599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7599
cuuuuucagg ggaagaaacu                                                   20


<210>  7600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7600
uggccagugc uuuuggggac                                                   20


<210>  7601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7601
caagucccca aaagcacugg                                                   20


<210>  7602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7602
ucucaagucc ccaaaagcac                                                   20


<210>  7603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7603
ggugcccggg cccugcgugg                                                   20


<210>  7604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7604
uugcaguuac cagggcuaga                                                   20


<210>  7605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7605
gcaucauugc aguuaccagg                                                   20


<210>  7606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7606
agggucaagg gcuggcuccc                                                   20


<210>  7607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7607
uaaacagggc agaaagggag                                                   20


<210>  7608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7608
uaaagcccag accauuuuac                                                   20


<210>  7609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7609
cauagguauu uuuuuugguc                                                   20


<210>  7610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7610
aggaccaaaa aaaauaccua                                                   20


<210>  7611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7611
uuauuuuacu cuccaauuac                                                   20


<210>  7612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7612
uugucuaaaa uuuuauaccc                                                   20


<210>  7613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7613
aguuccaacc agacacaaga                                                   20


<210>  7614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7614
ucccacgcug cuaaaucaag                                                   20


<210>  7615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7615
cagcuucugg ggauugggcc                                                   20


<210>  7616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7616
ccagaagcug ugauugugac                                                   20


<210>  7617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7617
uuggggcugc cguuugcccc                                                   20


<210>  7618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7618
gugcagagug agacuauaaa                                                   20


<210>  7619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7619
aguagagaua aaaagggaaa                                                   20


<210>  7620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7620
cuacuugaua uuuacuucug                                                   20


<210>  7621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7621
cugcccaagc accuguccca                                                   20


<210>  7622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7622
cuguuagaag accucacauc                                                   20


<210>  7623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7623
cugcuggcug uuggccagag                                                   20


<210>  7624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7624
auuccuuguc acgugggcgg                                                   20


<210>  7625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7625
accgucacuc ccugacccca                                                   20


<210>  7626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7626
auuaauagua aagcuagcag                                                   20


<210>  7627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7627
cauaaguuca gcuuauaguu                                                   20


<210>  7628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7628
gagcaauuua aauugccaga                                                   20


<210>  7629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7629
aauauaaaac caguuugcau                                                   20


<210>  7630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7630
cuuacuguau ugcuuuuuaa                                                   20


<210>  7631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7631
cuuuaaaaag caauacagua                                                   20


<210>  7632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7632
uuaaagaguc uugcagaaga                                                   20


<210>  7633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7633
uucuccacca cucacuggua                                                   20


<210>  7634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7634
agcauuccuu gaaauauggc                                                   20


<210>  7635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7635
gaauguuuag agcuggggag                                                   20


<210>  7636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7636
guagccggcc cucccccggg                                                   20


<210>  7637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7637
gcagggcucc cucucaugac                                                   20


<210>  7638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7638
ggucuccagc ucggaggccc                                                   20


<210>  7639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7639
acgugaaaaa agcaucucau                                                   20


<210>  7640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7640
caugaagaug uagugaaauu                                                   20


<210>  7641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7641
ucaugagaug cuuuuuucac                                                   20


<210>  7642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7642
ccaugugaag gacaccagag                                                   20


<210>  7643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7643
uguuccagug augaagaagg                                                   20


<210>  7644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7644
cuggaacagg auucgaagcg                                                   20


<210>  7645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7645
agcuugggcu ucagccagcc                                                   20


<210>  7646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7646
uauugaaaau uccaccagac                                                   20


<210>  7647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7647
uuguuucaau uucaagggcu                                                   20


<210>  7648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7648
cuuucagagu cggccgcaac                                                   20


<210>  7649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7649
aguugcggcc gacucugaaa                                                   20


<210>  7650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7650
aaucgaguug cggccgacuc                                                   20


<210>  7651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7651
aaaucccaac augcuuucua                                                   20


<210>  7652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7652
caacaugcuu ucuaaggagg                                                   20


<210>  7653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7653
aaaguuauuc augaugauuc                                                   20


<210>  7654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7654
ugaauaacuu uugauauuuc                                                   20


<210>  7655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7655
ucaugaauaa cuuuugauau                                                   20


<210>  7656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7656
ucaugacuuu cuaguccaau                                                   20


<210>  7657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7657
aaugcaaaau cgucaugacu                                                   20


<210>  7658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7658
ccacguuuaa aauacuugca                                                   20


<210>  7659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7659
ucgccacguu uaaaauacuu                                                   20


<210>  7660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7660
ugggcuacuu aggcuccauu                                                   20


<210>  7661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7661
gcggcugcau gcggcgccug                                                   20


<210>  7662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7662
acucgcuggu gaccaugaag                                                   20


<210>  7663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7663
ucauggucac cagcgagugg                                                   20


<210>  7664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7664
ugcacgacug ugugcagcug                                                   20


<210>  7665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7665
ccggucgucc gggcacacgg                                                   20


<210>  7666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7666
caagauccac caaggcauug                                                   20


<210>  7667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7667
ugugauuaaa caagucuggg                                                   20


<210>  7668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7668
accaaggcau ugcucggcgg                                                   20


<210>  7669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7669
cuguccugua ccgagacaug                                                   20


<210>  7670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7670
gcucacccau gucucgguac                                                   20


<210>  7671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7671
gcguccccgu ccagaaaggc                                                   20


<210>  7672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7672
gacugacagg uucugggacc                                                   20


<210>  7673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7673
guguaagagu ccuggucgcu                                                   20


<210>  7674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7674
guggaaucug uguaagaguc                                                   20


<210>  7675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7675
acugcggcac acugcccccu                                                   20


<210>  7676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7676
ugcucauagg agggggcagu                                                   20


<210>  7677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7677
ccgcagaccg cuacagggug                                                   20


<210>  7678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7678
aaauguucga aagacuaagg                                                   20


<210>  7679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7679
uccuuagucu uucgaacauu                                                   20


<210>  7680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7680
uaaacagccg gaguaguuuc                                                   20


<210>  7681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7681
ugagaccauc cuaagaagac                                                   20


<210>  7682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7682
uaagaagacc cucuaaggcu                                                   20


<210>  7683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7683
gacucaccua acuacacagg                                                   20


<210>  7684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7684
cauagccucc ccaguuagag                                                   20


<210>  7685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7685
uguggccgcc ucaugacccc                                                   20


<210>  7686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7686
uugucagcuu cucccuccuc                                                   20


<210>  7687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7687
auuguaugga aauuuuaaga                                                   20


<210>  7688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7688
caaauaacau auuuucauuu                                                   20


<210>  7689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7689
uuuacauauc acaaauaaca                                                   20


<210>  7690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7690
auccuuuaca uaucacaaau                                                   20


<210>  7691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7691
guccccaguu gauggcaacc                                                   20


<210>  7692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7692
acuggggacu gauucaguaa                                                   20


<210>  7693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7693
aggaaccuac ccaaaagaaa                                                   20


<210>  7694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7694
aaauaacaca aauucuccuu                                                   20


<210>  7695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7695
guggcucacg uugccaagcu                                                   20


<210>  7696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7696
cugggaaagc uagcucuggg                                                   20


<210>  7697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7697
gccaucgcug ggaaagcuag                                                   20


<210>  7698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7698
ugucauaucu guugucgugg                                                   20


<210>  7699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7699
guugucgugg gucuugauag                                                   20


<210>  7700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7700
agacccacga caacagauau                                                   20


<210>  7701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7701
caggacgcag gcaggcagga                                                   20


<210>  7702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7702
cacgugacgu ggcucccacu                                                   20


<210>  7703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7703
ccacccgcug agccuucucg                                                   20


<210>  7704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7704
accccugcug gaaggacaag                                                   20


<210>  7705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7705
cuuagugggg auguccccug                                                   20


<210>  7706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7706
ccacuaagag auggaccacu                                                   20


<210>  7707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7707
caggaggugc uuucagccau                                                   20


<210>  7708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7708
uccaugaaug gcugaaagca                                                   20


<210>  7709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7709
ggcugcagug gcaaagggcc                                                   20


<210>  7710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7710
ucuuggccau cugcugcugc                                                   20


<210>  7711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7711
gcugcugcau gguggcaggg                                                   20


<210>  7712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7712
uagguagcug gagaagaggc                                                   20


<210>  7713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7713
guguuuuauu uauuugccaa                                                   20


<210>  7714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7714
gccaaagggg aaaaauugaa                                                   20


<210>  7715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7715
ccuuucagaa aacuccuccc                                                   20


<210>  7716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7716
uuuacccucc aagcaugcau                                                   20


<210>  7717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7717
uauccuuuac ccuccaagca                                                   20


<210>  7718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7718
aaauaaaacu uaagccgcau                                                   20


<210>  7719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7719
aacaaaucaa aauaaaacuu                                                   20


<210>  7720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7720
auuaguaaau uugguuacuu                                                   20


<210>  7721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7721
aaaagauaau acgcuaugau                                                   20


<210>  7722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7722
uuuugaugug cugcuugagu                                                   20


<210>  7723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7723
uagcguauua ucuuuuugau                                                   20


<210>  7724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7724
cuggcacaua acacaucaua                                                   20


<210>  7725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7725
uugcaucccu ggcacauaac                                                   20


<210>  7726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7726
auaaauguga uauaucccau                                                   20


<210>  7727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7727
cauuuauuga uuugcauaug                                                   20


<210>  7728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7728
cuccuauuca acauaguacu                                                   20


<210>  7729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7729
ugguuugcug augacauaau                                                   20


<210>  7730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7730
uaggucacug uaaccucaaa                                                   20


<210>  7731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7731
cuugagucca agaguuugag                                                   20


<210>  7732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7732
ucccgccuca gccucccaag                                                   20


<210>  7733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7733
guaguauuuc uuuauaccaa                                                   20


<210>  7734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7734
uuauugguau aaagaaauac                                                   20


<210>  7735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7735
agcugagaaa gaaaucaagg                                                   20


<210>  7736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7736
aggaagcaau cccauuuaca                                                   20


<210>  7737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7737
cauuuacaau aacuacaaaa                                                   20


<210>  7738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7738
acauauucaa uguaaucccu                                                   20


<210>  7739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7739
cuaccaaaau accuacguaa                                                   20


<210>  7740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7740
uaaaauuuau auggaaccaa                                                   20


<210>  7741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7741
ccagcuuugu ucuuuuugcu                                                   20


<210>  7742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7742
cagauggcca cucugcucac                                                   20


<210>  7743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7743
guuaccuggc cugacuuuuc                                                   20


<210>  7744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7744
agacuggaca ugguuaguag                                                   20


<210>  7745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7745
aaaaaaauau uaagugccuu                                                   20


<210>  7746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7746
augugcugaa ccugaaacuc                                                   20


<210>  7747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7747
auuuugaaac uuccucucau                                                   20


<210>  7748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7748
acacuuuuuu uuuuuuuaca                                                   20


<210>  7749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7749
cggcacuuug ggaggccaag                                                   20


<210>  7750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7750
guuuugaccu caaguaguaa                                                   20


<210>  7751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7751
caaugaaugc aaaauaacaa                                                   20


<210>  7752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7752
uguuucugcc uuuugaugcu                                                   20


<210>  7753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7753
aaaggcagaa acaugaucuc                                                   20


<210>  7754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7754
uuguaauuug ccauguuagc                                                   20


<210>  7755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7755
aucauuguaa uuugccaugu                                                   20


<210>  7756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7756
caggaaugca aguauggucu                                                   20


<210>  7757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7757
guguauaaaa aaugaucaua                                                   20


<210>  7758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7758
cguacuuucc cuucucauua                                                   20


<210>  7759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7759
uauauuuuau uuuuauccuc                                                   20


<210>  7760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7760
ucccuccaga ggauuucaau                                                   20


<210>  7761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7761
ucuggaggga ggauaaaaau                                                   20


<210>  7762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7762
cuaauuuuaa aauuuuuaaa                                                   20


<210>  7763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7763
ggugaaagca gccuuuucug                                                   20


<210>  7764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7764
gccacuuaua guaacaauuc                                                   20


<210>  7765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7765
ucuucuugag cugucagaac                                                   20


<210>  7766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7766
ggcagaugcg ggucacugau                                                   20


<210>  7767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7767
gugacccgca ucugccugau                                                   20


<210>  7768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7768
cagagccaag acucaaugug                                                   20


<210>  7769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7769
acuuuuucua gguucucccu                                                   20


<210>  7770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7770
aaacaaaaca aaacauaagg                                                   20


<210>  7771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7771
uaggcccuaa gauauuuugg                                                   20


<210>  7772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7772
uagggccuau gaugucccaa                                                   20


<210>  7773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7773
cuacuuaaau gucuuuucau                                                   20


<210>  7774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7774
acaaaauucc auuucaaaca                                                   20


<210>  7775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7775
guuacaaaac ucugugcggc                                                   20


<210>  7776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7776
caggaaggcu gggcgcagug                                                   20


<210>  7777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7777
aaauaauauc acaggaaggc                                                   20


<210>  7778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7778
ugucgcaauc uaaauaauau                                                   20


<210>  7779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7779
acaaucaugu cgcaaucuaa                                                   20


<210>  7780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7780
uccacaauca ugucgcaauc                                                   20


<210>  7781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7781
gugacguggc ugccccagag                                                   20


<210>  7782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7782
gaggcucugg ggcagccacg                                                   20


<210>  7783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7783
cuucacuguc cucucauugg                                                   20


<210>  7784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7784
aucucuucac uguccucuca                                                   20


<210>  7785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7785
uccucccccg cagagucugu                                                   20


<210>  7786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7786
gggguccacu gccagcccug                                                   20


<210>  7787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7787
ugucugacca ccccaaccuc                                                   20


<210>  7788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7788
cggcagcacc uucucguucg                                                   20


<210>  7789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7789
aggcaggaac cccuuccugc                                                   20


<210>  7790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7790
cugggcaggc acucugcugc                                                   20


<210>  7791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7791
gaucaaacac ggguuugucc                                                   20


<210>  7792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7792
gaucccuggg caggcacucu                                                   20


<210>  7793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7793
aacacggguu uguccagccu                                                   20


<210>  7794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7794
guguccccug gugagccagc                                                   20


<210>  7795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7795
gaagaggcug gcucaccagg                                                   20


<210>  7796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7796
gggcgaccug gcacugcacu                                                   20


<210>  7797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7797
gggcucccgu uggggccgcc                                                   20


<210>  7798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7798
ggugcccgcc cacccaagca                                                   20


<210>  7799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7799
ggggcuuggc ucugggcuug                                                   20


<210>  7800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7800
cugcccuccc acaggagugg                                                   20


<210>  7801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7801
ugcccuguaa gugacacaca                                                   20


<210>  7802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7802
caacaugucu gacauuacag                                                   20


<210>  7803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7803
guucuuuuca caugaaaagg                                                   20


<210>  7804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7804
uuuucaugug aaaagaacag                                                   20


<210>  7805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7805
gaggaacaca aggggcagac                                                   20


<210>  7806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7806
gacacaguug cagacugaaa                                                   20


<210>  7807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7807
gaaauuguga cuuaccgcca                                                   20


<210>  7808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7808
aauggcaaau acacuuucac                                                   20


<210>  7809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7809
cacugguguu cagggccaug                                                   20


<210>  7810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7810
uaacuugcug guuuaaaagc                                                   20


<210>  7811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7811
cacacucuca auucgucuau                                                   20


<210>  7812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7812
aaaacuuacu uucuguguuu                                                   20


<210>  7813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7813
cugugcacaa aauucuuuaa                                                   20


<210>  7814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7814
guccaugaaa agaaucccug                                                   20


<210>  7815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7815
ucagugaaau aagacauucc                                                   20


<210>  7816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7816
gagaaaucuu cagugaaaua                                                   20


<210>  7817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7817
uuaucauuuu gguucaauga                                                   20


<210>  7818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7818
uuuugguuca augauuuaaa                                                   20


<210>  7819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7819
uugaaccaaa augauaagga                                                   20


<210>  7820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7820
ucaccucacg cuuuuguccc                                                   20


<210>  7821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7821
cugugggcca gggaugggcu                                                   20


<210>  7822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7822
cuggcccaca gcgaugccag                                                   20


<210>  7823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7823
uggguuacac acgcacuggc                                                   20


<210>  7824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7824
cucuggucuc ggcuucaggu                                                   20


<210>  7825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7825
cgacacucgu gugguggaga                                                   20


<210>  7826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7826
ccaccacacg agugucggga                                                   20


<210>  7827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7827
ugucauuuaa ucagucuuaa                                                   20


<210>  7828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7828
gucuuaaggu ggagggagga                                                   20


<210>  7829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7829
ucccuccacc uuaagacuga                                                   20


<210>  7830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7830
aggauaaagu gaccgguguu                                                   20


<210>  7831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7831
uggauuuggu uccggguccu                                                   20


<210>  7832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7832
uucaaaacac cggucacuuu                                                   20


<210>  7833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7833
guucaugcuu ucucuuucug                                                   20


<210>  7834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7834
uucauguaua aauugccugc                                                   20


<210>  7835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7835
uuuggaggca aauaaaacuu                                                   20


<210>  7836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7836
auugcugaca gaagcaaucu                                                   20


<210>  7837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7837
uggccacgca gagauccccu                                                   20


<210>  7838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7838
cugcguggcc aggauacacu                                                   20


<210>  7839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7839
ccuggugcua gggcuuucca                                                   20


<210>  7840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7840
gcacacccug aauuucagga                                                   20


<210>  7841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7841
agcccgccca cugcgguucc                                                   20


<210>  7842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7842
ucaguuucuu ugcuuauaag                                                   20


<210>  7843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7843
uguuuaaugu gcacaugagc                                                   20


<210>  7844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7844
agagcucaug ugcacauuaa                                                   20


<210>  7845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7845
gugucacauu cugccguugu                                                   20


<210>  7846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7846
aacaacggca gaaugugaca                                                   20


<210>  7847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7847
ccccacucug ccucggugcc                                                   20


<210>  7848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7848
agcagcucac aguagucugc                                                   20


<210>  7849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7849
caccugcaga cuacugugag                                                   20


<210>  7850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7850
cuguguggaa acacagccag                                                   20


<210>  7851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7851
uuuuauaggc uguggucagu                                                   20


<210>  7852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7852
gcucagcugg gcugucucug                                                   20


<210>  7853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7853
ugucuaguuu uggugauuaa                                                   20


<210>  7854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7854
ccaaaacuag acaggaugac                                                   20


<210>  7855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7855
auuaaucacc aaaacuagac                                                   20


<210>  7856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7856
cucacuuaga aauauuuugu                                                   20


<210>  7857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7857
ugcuuuuaua gcuuaggcuc                                                   20


<210>  7858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7858
uugucaaguu ggaguguguu                                                   20


<210>  7859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7859
gccccuuucu ucugaaaaag                                                   20


<210>  7860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7860
gcucccugcc cccacccaca                                                   20


<210>  7861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7861
cccuccagcu cgaccucaca                                                   20


<210>  7862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7862
uccuuuucuc auuucuucac                                                   20


<210>  7863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7863
ccucacccac ugcagccucc                                                   20


<210>  7864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7864
accuguggag gcugcagugg                                                   20


<210>  7865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7865
gggagcuccc agagcgccca                                                   20


<210>  7866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7866
ccauguccuc cucaugccuu                                                   20


<210>  7867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7867
ucccgcuccc uucuccugaa                                                   20


<210>  7868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7868
cugcugcugc ugugggggca                                                   20


<210>  7869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7869
gcccagcccc ugcacuggac                                                   20


<210>  7870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7870
ugcgucccac ccuggucucc                                                   20


<210>  7871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7871
ugagcgaugg ccacugucaa                                                   20


<210>  7872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7872
cucaggaugg gggcaggugg                                                   20


<210>  7873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7873
uuuuaauuau ucaucugugu                                                   20


<210>  7874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7874
guguuggugc uuuugucccc                                                   20


<210>  7875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7875
uucacucaac agacagcucu                                                   20


<210>  7876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7876
gguguucagc agacaucagc                                                   20


<210>  7877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7877
gccagagcgu cagggcgagg                                                   20


<210>  7878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7878
cugaaagcca cuguccccgc                                                   20


<210>  7879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7879
uccgccaugg ccaggucuga                                                   20


<210>  7880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7880
gccugucagc uguggagcug                                                   20


<210>  7881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7881
cuuggggcaa gucacuuucu                                                   20


<210>  7882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7882
cgccgguccu uguuagcgaa                                                   20


<210>  7883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7883
ggcagccguu ugugacagcu                                                   20


<210>  7884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7884
ggcaauuacg guaacccucc                                                   20


<210>  7885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7885
caugcuacuu uuggugcaca                                                   20


<210>  7886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7886
acauggguaa guacuccgag                                                   20


<210>  7887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7887
cuugguuucu gaaaaaggug                                                   20


<210>  7888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7888
agcugaaaaa aaaaaauagu                                                   20


<210>  7889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7889
uacuauuuuu uuuuuucagc                                                   20


<210>  7890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7890
aacagacaca uagagagcuu                                                   20


<210>  7891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7891
acuucuauuc aaauacacug                                                   20


<210>  7892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7892
uaaaaugaua acaaaaaaga                                                   20


<210>  7893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7893
uuuuaugauc gacuucuauu                                                   20


<210>  7894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7894
augggucaag gaagaaauua                                                   20


<210>  7895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7895
uacaguuuag aaccauuuau                                                   20


<210>  7896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7896
ucaccaguag aauauaauca                                                   20


<210>  7897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7897
ccaguagaau auaaucaaag                                                   20


<210>  7898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7898
aagugauuuu cagugaaaaa                                                   20


<210>  7899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7899
cuuugauuau auucuacugg                                                   20


<210>  7900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7900
ucauuuccuu aauuugcauu                                                   20


<210>  7901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7901
aaauagaaaa aaccaaacag                                                   20


<210>  7902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7902
agaaaaagag ggaggccagg                                                   20


<210>  7903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7903
cagcacuuug ggaggcugau                                                   20


<210>  7904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7904
gccucccaaa gugcugagau                                                   20


<210>  7905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7905
uccugcauca gccucccaaa                                                   20


<210>  7906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7906
cuugggccca ggaauuugag                                                   20


<210>  7907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7907
cuacaaaaaa agaaaaagag                                                   20


<210>  7908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7908
uuguccucuu ccucuuuuuc                                                   20


<210>  7909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7909
agaaugaaag acagguccua                                                   20


<210>  7910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7910
aauguacagu auaaaguugu                                                   20


<210>  7911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7911
uuaggaaaau auaaaugauc                                                   20


<210>  7912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7912
uuuauauuuu ccuaaagauu                                                   20


<210>  7913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7913
aaguuggccu aagaagaagu                                                   20


<210>  7914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7914
guuucuacuu cuucuuaggc                                                   20


<210>  7915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7915
aaucaguuuc uacuucuucu                                                   20


<210>  7916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7916
acauaggcaa aaaugauuug                                                   20


<210>  7917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7917
uuuuugccua uguugauuua                                                   20


<210>  7918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7918
uugacuucca aaucauuuuu                                                   20


<210>  7919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7919
aaacccccau aggcaccaug                                                   20


<210>  7920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7920
guauauuggu uugggcaugg                                                   20


<210>  7921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7921
gucagcuuag gcuaaguaau                                                   20


<210>  7922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7922
ugguggguuu aacaaagcag                                                   20


<210>  7923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7923
gcuuuguuaa acccaccagg                                                   20


<210>  7924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7924
ggucauggcu cucagccaua                                                   20


<210>  7925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7925
cagcuuuaua ggaaaguuaa                                                   20


<210>  7926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7926
gacucagagc uccgcuccuu                                                   20


<210>  7927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7927
aaacagugug acucuggaac                                                   20


<210>  7928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7928
ucagccuggu guuaccuagu                                                   20


<210>  7929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7929
accuccuaga auacagcuug                                                   20


<210>  7930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7930
cgucagcacc ugugaaucgu                                                   20


<210>  7931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7931
ugagaaggag gcgguggccu                                                   20


<210>  7932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7932
ggucaccaug cuggucccau                                                   20


<210>  7933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7933
aacuuaaaaa gucauuuguc                                                   20


<210>  7934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7934
aacaaucaaa cuuaaaaagu                                                   20


<210>  7935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7935
gaaguuauau aaaagguaca                                                   20


<210>  7936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7936
aacauauuau auuuauuauu                                                   20


<210>  7937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7937
cagucccagc aaauaccauu                                                   20


<210>  7938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7938
accaucugcc ccugaugugu                                                   20


<210>  7939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7939
gccccugaug uguagaguag                                                   20


<210>  7940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7940
ggggcagaug guggaugcuc                                                   20


<210>  7941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7941
uuuaugcuuu uacacacuca                                                   20


<210>  7942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7942
cuggacucuu ucaguggaag                                                   20


<210>  7943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7943
aaaugaagua agucaguuuc                                                   20


<210>  7944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7944
acccuaacug acuucauuua                                                   20


<210>  7945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7945
uugaaaaaug uucugugucu                                                   20


<210>  7946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7946
ugagggcucc cuguggucag                                                   20


<210>  7947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7947
gaccacaggg agcccucagg                                                   20


<210>  7948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7948
uaaaaauuca gagugacaag                                                   20


<210>  7949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7949
ccuaacacuu cccacacuga                                                   20


<210>  7950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7950
cacguuucua guacugacuc                                                   20


<210>  7951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7951
gaauucuggg ucuuuccugg                                                   20


<210>  7952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7952
cgaggggucc gugagaccug                                                   20


<210>  7953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7953
ccagcagcac uuucugggcu                                                   20


<210>  7954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7954
gugacuaugc ugggcccaga                                                   20


<210>  7955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7955
guaaaauggg cugauugacu                                                   20


<210>  7956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7956
gcccauuuua cagaugaagc                                                   20


<210>  7957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7957
cagucaauca gcccauuuua                                                   20


<210>  7958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7958
auagcaugua aacacuuuuc                                                   20


<210>  7959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7959
aucucaguca aucagcccau                                                   20


<210>  7960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7960
ggaauagcac cuccucagaa                                                   20


<210>  7961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7961
cuguuuucua acccucagca                                                   20


<210>  7962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7962
caacaaaagc cugccacaac                                                   20


<210>  7963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7963
ggcauccuau gggcaggcca                                                   20


<210>  7964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7964
uaugggcagg ccagaagugu                                                   20


<210>  7965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7965
gguaaggcug uaugagugag                                                   20


<210>  7966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7966
acauuuccca guaccaccac                                                   20


<210>  7967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7967
ccaaguggcc uggugugugg                                                   20


<210>  7968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7968
uccccuugga aucaccuugg                                                   20


<210>  7969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7969
ccuuggaauc accuuggaaa                                                   20


<210>  7970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7970
ccuuggaaaa cccuggauca                                                   20


<210>  7971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7971
aggguuuucc aaggugauuc                                                   20


<210>  7972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7972
uuuugaaaga ugcucaugga                                                   20


<210>  7973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7973
uucaaaauga uccaggguuu                                                   20


<210>  7974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7974
cauuggggcu caucacagua                                                   20


<210>  7975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7975
caguaucaag guagaagagg                                                   20


<210>  7976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7976
agguagaaga ggaagcugag                                                   20


<210>  7977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7977
uacuggucuc agcuuccucu                                                   20


<210>  7978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7978
caugguggcu gaagguggug                                                   20


<210>  7979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7979
cugccagacc ccauggucgu                                                   20


<210>  7980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7980
ugaaagagga ggacaccaca                                                   20


<210>  7981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7981
ggucuccaag aaccaagggg                                                   20


<210>  7982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7982
accccuuccu acucaguggc                                                   20


<210>  7983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7983
uguguguucc aggcugugug                                                   20


<210>  7984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7984
cuacagggag aggcagggcc                                                   20


<210>  7985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7985
gcugcccugg gcgccuggca                                                   20


<210>  7986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7986
caggccccca aggggcuggc                                                   20


<210>  7987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7987
cccacccacc cccgcaguca                                                   20


<210>  7988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7988
ccgaagcacc aaagccaacc                                                   20


<210>  7989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7989
aagagacagg ucuccggugg                                                   20


<210>  7990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7990
caggggcagu ggggaggggc                                                   20


<210>  7991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7991
ggagcccugg gcgccccucc                                                   20


<210>  7992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7992
gcugaccuca gagcagggcu                                                   20


<210>  7993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7993
gggcagcgug aggccucaca                                                   20


<210>  7994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7994
agacccuagg cugggcucug                                                   20


<210>  7995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7995
cauccagacc cuaggcuggg                                                   20


<210>  7996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7996
ucacggggcu gacgguucuc                                                   20


<210>  7997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7997
ucuagggugc caucgccccu                                                   20


<210>  7998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7998
ccccucccca cugcuguucc                                                   20


<210>  7999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  7999
gcuggguguc cccaacccca                                                   20


<210>  8000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8000
gagagacggc cuccaccacc                                                   20


<210>  8001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8001
agguucuucu gcagagaggc                                                   20


<210>  8002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8002
aaugcccagg ccagagcuug                                                   20


<210>  8003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8003
gagccggcug gccuaaccag                                                   20


<210>  8004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8004
caggcaagag caggcccugg                                                   20


<210>  8005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8005
ccaggcuucc cccacacuga                                                   20


<210>  8006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8006
uaggccuggg cugccugugg                                                   20


<210>  8007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8007
gccccuaccc caggggucac                                                   20


<210>  8008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8008
ggcuucccag acuggcaucu                                                   20


<210>  8009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8009
gccccgcucu gggcacugcu                                                   20


<210>  8010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8010
gggcucagac gcucagacca                                                   20


<210>  8011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8011
ucugucaugg uuccgcgccg                                                   20


<210>  8012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8012
ccgccgcugu caccccgccg                                                   20


<210>  8013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8013
cacccagacc cgggccuggc                                                   20


<210>  8014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8014
cugccccaca cccucccugg                                                   20


<210>  8015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8015
cuccugcguc cccucugcag                                                   20


<210>  8016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8016
cuuccuauac cagguccccu                                                   20


<210>  8017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8017
gccccagccu ggcagggccu                                                   20


<210>  8018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8018
ccugccccac cacggccccg                                                   20


<210>  8019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8019
accaagcauc accugcccca                                                   20


<210>  8020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8020
caggaaggca cccgggacag                                                   20


<210>  8021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8021
cuccaacagg gacaaagacu                                                   20


<210>  8022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8022
gacaguccca ggaggcaggg                                                   20


<210>  8023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8023
gugagucugu aggugaacau                                                   20


<210>  8024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8024
cguauccugc gcaguugaga                                                   20


<210>  8025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8025
ugcgcaguug agaucugcag                                                   20


<210>  8026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8026
caacugcgca ggauacggga                                                   20


<210>  8027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8027
gcagccuucu ggggcuggcg                                                   20


<210>  8028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8028
ccucccacgc cagccccaga                                                   20


<210>  8029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8029
acccagaggg ggcauggcac                                                   20


<210>  8030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8030
gaccgaccuc ugggcaaccc                                                   20


<210>  8031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8031
ccucaucuga ccgaccucug                                                   20


<210>  8032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8032
gggccucuga gcggagagga                                                   20


<210>  8033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8033
agggaggcuu augaggggcc                                                   20


<210>  8034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8034
acaagggagg uggucuccag                                                   20


<210>  8035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8035
ccacugguaa caaaaagaac                                                   20


<210>  8036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8036
gggcccuucc cagaaggaaa                                                   20


<210>  8037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8037
ugagcacguc uuucuguuau                                                   20


<210>  8038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8038
aagggcugcu cagccacagc                                                   20


<210>  8039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8039
uguggagagu guggccccag                                                   20


<210>  8040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8040
agcucagaaa agccaccggg                                                   20


<210>  8041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8041
cucggguuuc ugaguuucag                                                   20


<210>  8042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8042
ggcccaagac auggacugcu                                                   20


<210>  8043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8043
gcccgggggc aggcgcggaa                                                   20


<210>  8044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8044
uugcucucgg ugggacugag                                                   20


<210>  8045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8045
accaccagga ggcucugcuc                                                   20


<210>  8046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8046
cagcuccggg cugaagaccg                                                   20


<210>  8047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8047
ucuccccaua gaaacaucaa                                                   20


<210>  8048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8048
agaacagggc gaccuucccu                                                   20


<210>  8049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8049
gagagcuggg guucagcucu                                                   20


<210>  8050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8050
ggagccucgu ccugggcugc                                                   20


<210>  8051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence ATCN PAM

<400>  8051
ccaagggcag cccaggacga                                                   20


<210>  8052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8052
aaaacugaaa uccaaagaaa                                                   20


<210>  8053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8053
ccaggaagcc gguguaaaau                                                   20


<210>  8054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8054
cccaccagaa aggugguauu                                                   20


<210>  8055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8055
cccccaccag aaagguggua                                                   20


<210>  8056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8056
agcugugcug cgcuuggcuc                                                   20


<210>  8057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8057
gccacgggug gguuuugcuc                                                   20


<210>  8058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8058
aagucucugc cacggguggg                                                   20


<210>  8059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8059
cuaagucucu gccacgggug                                                   20


<210>  8060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8060
auggacaagg aacauggguc                                                   20


<210>  8061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8061
cuccagcagg aaaacaauga                                                   20


<210>  8062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8062
agcaggaaaa caaugagaaa                                                   20


<210>  8063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8063
uuguuuuccu gcuggaggga                                                   20


<210>  8064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8064
uccauuucuc auuguuuucc                                                   20


<210>  8065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8065
uucaaacacu ugacuugccc                                                   20


<210>  8066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8066
uguaaaaucc gaugacaguc                                                   20


<210>  8067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8067
uuuccugcag gaaggcacug                                                   20


<210>  8068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8068
ggggucccgc ggacaggagu                                                   20


<210>  8069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8069
uguccgcggg accccagagc                                                   20


<210>  8070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8070
uggcuguaga gguucgagca                                                   20


<210>  8071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8071
acagccagga ggaagcaggg                                                   20


<210>  8072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8072
aaccucuaca gccaggagga                                                   20


<210>  8073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8073
agacaaguca ccuugcucga                                                   20


<210>  8074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8074
caccucagug ccuuaacgga                                                   20


<210>  8075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8075
gugccuuaac ggauagaagc                                                   20


<210>  8076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8076
uccccucaca ucacagugca                                                   20


<210>  8077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8077
caucacagug cagcacaagu                                                   20


<210>  8078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8078
gguggcagcg gggaaggggc                                                   20


<210>  8079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8079
agggcucggg uggcagcggg                                                   20


<210>  8080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8080
ccuagguccu gggcauccag                                                   20


<210>  8081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8081
uagguccugg gcauccagac                                                   20


<210>  8082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8082
cauggccugu gccccccauu                                                   20


<210>  8083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8083
ugcuguccuc ccauggccug                                                   20


<210>  8084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8084
caugcugucc ucccauggcc                                                   20


<210>  8085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8085
augguuguca ggaccagggc                                                   20


<210>  8086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8086
ucuaugguug ucaggaccag                                                   20


<210>  8087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8087
cguggugagu gagcacaugg                                                   20


<210>  8088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8088
ccacgugagc accugccucc                                                   20


<210>  8089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8089
cucaccacgu gagcaccugc                                                   20


<210>  8090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8090
ccccuggggc gcaggcaggg                                                   20


<210>  8091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8091
gggggaccug uaaccagauc                                                   20


<210>  8092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8092
ggcauccccg uggaucuggu                                                   20


<210>  8093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8093
gugggggccu gccaccccug                                                   20


<210>  8094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8094
cagaauggcc uggcuggagg                                                   20


<210>  8095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8095
gaauggccug gcuggaggaa                                                   20


<210>  8096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8096
agccaggcca uucugagagu                                                   20


<210>  8097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8097
gagacuccaa gaaacacuga                                                   20


<210>  8098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8098
gaggccauca cagcuuccag                                                   20


<210>  8099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8099
aagaaacacu gacaugaaac                                                   20


<210>  8100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8100
accaaugacc ccagucaaua                                                   20


<210>  8101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8101
caguaacagc ucaaccaaug                                                   20


<210>  8102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8102
guccaagacu cacaguaaca                                                   20


<210>  8103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8103
ucacaugcuc ccaacaauuc                                                   20


<210>  8104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8104
caugcuccca acaauuccag                                                   20


<210>  8105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8105
caacaauucc agaaggcagg                                                   20


<210>  8106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8106
gcauccccac cugacacuag                                                   20


<210>  8107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8107
guuucccuag ugucaggugg                                                   20


<210>  8108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8108
cacaccugug ccucaguuuc                                                   20


<210>  8109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8109
ucccucccac accugugccu                                                   20


<210>  8110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8110
agggccuggc ugggaauucu                                                   20


<210>  8111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8111
aaugcuauuu agacacauga                                                   20


<210>  8112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8112
gcauuuauuu uucuucaaau                                                   20


<210>  8113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8113
ccauuauuca ccuuugcacc                                                   20


<210>  8114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8114
aacaaaacca cacccuggcu                                                   20


<210>  8115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8115
cagaugugca ccuucacaca                                                   20


<210>  8116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8116
gaugugcacc uucacacauu                                                   20


<210>  8117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8117
aaauguguga aggugcacau                                                   20


<210>  8118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8118
ccucuuaagg ucgaacaaaa                                                   20


<210>  8119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8119
ucuuaagguc gaacaaaaug                                                   20


<210>  8120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8120
uaaggucgaa caaaaugacc                                                   20


<210>  8121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8121
gccugugggg caggacacug                                                   20


<210>  8122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8122
guguccugcc ccacaggcug                                                   20


<210>  8123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8123
cccgucugcc cugccugcug                                                   20


<210>  8124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8124
gcaggcaggg cagacggggg                                                   20


<210>  8125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8125
cgacucucug ccucugacuc                                                   20


<210>  8126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8126
acucucugcc ucugacucgc                                                   20


<210>  8127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8127
cugccucuga cucgcccauu                                                   20


<210>  8128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8128
gccucugacu cgcccauuua                                                   20


<210>  8129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8129
gacucgccca uuuaacagaa                                                   20


<210>  8130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8130
cccauuuaac agaaaccaua                                                   20


<210>  8131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8131
uucccuggca gggcagggcu                                                   20


<210>  8132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8132
ccuucccugg cagggcaggg                                                   20


<210>  8133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8133
gggcucuccu ucccuggcag                                                   20


<210>  8134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8134
gucaucacuc agggcucucc                                                   20


<210>  8135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8135
cugcgccgac ucugucauca                                                   20


<210>  8136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8136
cccucugucu gcagcccagg                                                   20


<210>  8137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8137
gucugcagcc caggcucuua                                                   20


<210>  8138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8138
uaauugcccu gcaaaugccg                                                   20


<210>  8139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8139
caugccuugc cuugugccag                                                   20


<210>  8140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8140
cccaaccaca aacagaaacc                                                   20


<210>  8141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8141
gcaaagcgca ggaaaugaga                                                   20


<210>  8142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8142
uuuccugcgc uuugcugagg                                                   20


<210>  8143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8143
cgucucauuu ccugcgcuuu                                                   20


<210>  8144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8144
gcgggcagcu cacgucucau                                                   20


<210>  8145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8145
cagcgggcag cucacgucuc                                                   20


<210>  8146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8146
uaggaaguga cucucagcgg                                                   20


<210>  8147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8147
cuggccucuu aggaagugac                                                   20


<210>  8148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8148
agagcacaug ggcucucagg                                                   20


<210>  8149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8149
ugagguggcu uuguagaacc                                                   20


<210>  8150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8150
caggcguccg cacugcacuc                                                   20


<210>  8151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8151
ggcguccgca cugcacuccc                                                   20


<210>  8152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8152
cgcugaccac agccugagug                                                   20


<210>  8153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8153
ggcugugguc agcgggagug                                                   20


<210>  8154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8154
cagaaagccu uccuuuuucc                                                   20


<210>  8155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8155
gcauccaggu caugccaccc                                                   20


<210>  8156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8156
cccggcggcu cugcauccag                                                   20


<210>  8157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8157
ggggcucccc cggcggcucu                                                   20


<210>  8158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8158
gaauucagaa ggcucugggg                                                   20


<210>  8159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8159
gcugugugug guucucugaa                                                   20


<210>  8160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8160
cagcugugug ugguucucug                                                   20


<210>  8161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8161
cucagcugug ugugguucuc                                                   20


<210>  8162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8162
gacucagcac ugccaagcgu                                                   20


<210>  8163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8163
gcacugccaa gcguccuccc                                                   20


<210>  8164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8164
caggacuucc ugagcccccu                                                   20


<210>  8165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8165
ggaaguccug ggaggacgcu                                                   20


<210>  8166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8166
gugccaggcg cccgccagga                                                   20


<210>  8167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8167
uggcgggcgc cuggcacgga                                                   20


<210>  8168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8168
ccuggcgggc gccuggcacg                                                   20


<210>  8169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8169
cucuccuggc gggcgccugg                                                   20


<210>  8170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8170
gccugugcag cauccggaac                                                   20


<210>  8171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8171
ccucagagag aaacgugcca                                                   20


<210>  8172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8172
gagagaaacg ugccaggcca                                                   20


<210>  8173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8173
gaggugagcu gcuggaaagc                                                   20


<210>  8174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8174
cugaggugag cugcuggaaa                                                   20


<210>  8175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8175
aagugcccag cuguggcagg                                                   20


<210>  8176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8176
aaucccaagu cccuggaaca                                                   20


<210>  8177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8177
cauaggcccc acucgugcca                                                   20


<210>  8178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8178
uaggccccac ucgugccagg                                                   20


<210>  8179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8179
ugccaggccc caguguccac                                                   20


<210>  8180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8180
cacagccuuc caagccccag                                                   20


<210>  8181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8181
gucaucgccc cucacccuca                                                   20


<210>  8182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8182
cccucagcca ccagugggga                                                   20


<210>  8183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8183
gccaccagug gggagcccca                                                   20


<210>  8184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8184
ccacuggugg cugaggguga                                                   20


<210>  8185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8185
uuuuggggcu ccccacuggu                                                   20


<210>  8186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8186
ucucugcacu ucgggaccaa                                                   20


<210>  8187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8187
gcacuucggg accaaacaga                                                   20


<210>  8188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8188
ggggcccgcc cccaucugcc                                                   20


<210>  8189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8189
caaccaggug gccaagguac                                                   20


<210>  8190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8190
accagguggc caagguacag                                                   20


<210>  8191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8191
guaccuuggc caccugguug                                                   20


<210>  8192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8192
cuucaagggc ccaugaccaa                                                   20


<210>  8193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8193
ucaagggccc augaccaagu                                                   20


<210>  8194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8194
ggugacugag gcuggguuaa                                                   20


<210>  8195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8195
gucaccugag gguuuucggg                                                   20


<210>  8196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8196
uguuaaccca gccucaguca                                                   20


<210>  8197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8197
guacugcuca guccuggcag                                                   20


<210>  8198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8198
guccuggcag guucccacaa                                                   20


<210>  8199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8199
ggcuucucuu ggcaaaggcc                                                   20


<210>  8200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8200
uggcaaaggc caugucaucg                                                   20


<210>  8201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8201
guaaggcaga uuuauaagga                                                   20


<210>  8202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8202
uacaaagcgg ggggacaaga                                                   20


<210>  8203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8203
gaaaacgguc ugggggugca                                                   20


<210>  8204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8204
cuugucugca cccccagacc                                                   20


<210>  8205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8205
ucucggagug caagguugag                                                   20


<210>  8206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8206
gagugcaagg uugagcaugg                                                   20


<210>  8207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8207
gagaagagcu cgcuugucug                                                   20


<210>  8208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8208
accuugcacu ccgagaagag                                                   20


<210>  8209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8209
guggguuaug cuggcugggu                                                   20


<210>  8210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8210
ucaaagaugg aaaacacaaa                                                   20


<210>  8211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8211
aagauggaaa acacaaauuc                                                   20


<210>  8212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8212
ggaugaauuu guguuuucca                                                   20


<210>  8213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8213
uuggugaugg ccaggaaauc                                                   20


<210>  8214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8214
cccaggucca gguaaguguc                                                   20


<210>  8215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8215
cagguccagg uaagugucca                                                   20


<210>  8216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8216
cccccaugcc gggaauucuc                                                   20


<210>  8217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8217
cccaugccgg gaauucucac                                                   20


<210>  8218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8218
ccuccuagug accaggaacu                                                   20


<210>  8219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8219
uagugaccag gaacuuccag                                                   20


<210>  8220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8220
gugcuguguu ucuugcuugg                                                   20


<210>  8221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8221
cuugaaaaga cuuuaaagaa                                                   20


<210>  8222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8222
ugaaaagacu uuaaagaaag                                                   20


<210>  8223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8223
uccugggagu guucaaaguc                                                   20


<210>  8224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8224
caggaagaga cggugcagga                                                   20


<210>  8225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8225
ggaggcuaag gcaggagaau                                                   20


<210>  8226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8226
cgaguagcug ggauuacagg                                                   20


<210>  8227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8227
ugccuuagcc ucccgaguag                                                   20


<210>  8228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8228
uggguucaag uaauucuccu                                                   20


<210>  8229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8229
gccuccuggg uucaaguaau                                                   20


<210>  8230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8230
cugcaaccuc cgccuccugg                                                   20


<210>  8231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8231
agccugggcg acagagcaag                                                   20


<210>  8232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8232
gucgcccagg cuugagugca                                                   20


<210>  8233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8233
gucucaaaaa aaaaaaaaaa                                                   20


<210>  8234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8234
aaaaaaaaaa aaaagaaaag                                                   20


<210>  8235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8235
cucuguugcc caggcuagag                                                   20


<210>  8236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8236
guugcccagg cuagagagca                                                   20


<210>  8237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8237
agccugggca acagagugag                                                   20


<210>  8238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8238
cuagccuggg caacagagug                                                   20


<210>  8239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8239
aaccccugag cuuaagugau                                                   20


<210>  8240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8240
gggguuggag gcugcaguaa                                                   20


<210>  8241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8241
cacauuaucc uccugaguag                                                   20


<210>  8242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8242
ugaguagcug agacuacagg                                                   20


<210>  8243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8243
ggaggauaau gugggagaau                                                   20


<210>  8244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8244
gcuacucagg aggauaaugu                                                   20


<210>  8245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8245
acaaaaauau uaaaaaauca                                                   20


<210>  8246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8246
cugugaugcc caggcugguc                                                   20


<210>  8247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8247
ugggcucaag cagucaccca                                                   20


<210>  8248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8248
agcagucacc caccucagcc                                                   20


<210>  8249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8249
gccucccaaa gcacuaggau                                                   20


<210>  8250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8250
caaagcacua ggauuacagg                                                   20


<210>  8251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8251
caccuguaau ccuagugcuu                                                   20


<210>  8252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8252
ugcuaaaagg gcuuccucuc                                                   20


<210>  8253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8253
cugaacuucc cuaccuuucu                                                   20


<210>  8254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8254
gaacuucccu accuuucuuc                                                   20


<210>  8255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8255
auguuggcag uccuacuccc                                                   20


<210>  8256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8256
caauuaaccu ggggcugucu                                                   20


<210>  8257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8257
caaugacugc agaucuuaua                                                   20


<210>  8258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8258
acaccaauau uccugguccc                                                   20


<210>  8259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8259
cucaacacca auauuccugg                                                   20


<210>  8260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8260
ggccacccau ccacuuucca                                                   20


<210>  8261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8261
cucuggccac ccauccacuu                                                   20


<210>  8262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8262
cccucuggcc acccauccac                                                   20


<210>  8263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8263
cuuuuaccua ucagcucucc                                                   20


<210>  8264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8264
uggcuuggga agcaggaguc                                                   20


<210>  8265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8265
ugcuucccaa gccaggagcg                                                   20


<210>  8266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8266
cagaucuacu ggucaguuug                                                   20


<210>  8267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8267
gaucuacugg ucaguuugau                                                   20


<210>  8268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8268
cacuguccuc aguguuguca                                                   20


<210>  8269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8269
guguugucag ccacaaaaua                                                   20


<210>  8270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8270
ugcuaaucau ucucuacuua                                                   20


<210>  8271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8271
acuuauuuuu gauuuuaaua                                                   20


<210>  8272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8272
guguaaauuc auaaacuggc                                                   20


<210>  8273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8273
aguauauguc ucaguguaaa                                                   20


<210>  8274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8274
gagcagaucu guuugggagg                                                   20


<210>  8275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8275
gaggcagaau uccaaacuca                                                   20


<210>  8276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8276
caaacagauc ugcucagagg                                                   20


<210>  8277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8277
aaugcuaguc acugaggaua                                                   20


<210>  8278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8278
gugacuagca uuagaggccu                                                   20


<210>  8279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8279
ugcaggugca gccuaggguc                                                   20


<210>  8280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8280
ccugcaggug cagccuaggg                                                   20


<210>  8281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8281
aacuauucga cagguccugg                                                   20


<210>  8282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8282
aguagcucug uaccuguaau                                                   20


<210>  8283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8283
guaccuguaa uauaggaauc                                                   20


<210>  8284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8284
ggauccuggu auccagggau                                                   20


<210>  8285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8285
aaacuuugug ccuguggucc                                                   20


<210>  8286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8286
gccuucccag uagcugggac                                                   20


<210>  8287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8287
uugcucagcc uucccaguag                                                   20


<210>  8288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8288
ggaguucaag gcaagccugg                                                   20


<210>  8289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8289
ugaguucaag ugauccuccu                                                   20


<210>  8290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8290
cuauguugcc caggcuugcc                                                   20


<210>  8291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8291
cugcaucuua ccgcauuuuu                                                   20


<210>  8292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8292
cacugcaucu uaccgcauuu                                                   20


<210>  8293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8293
uuugauuagu uucccucaaa                                                   20


<210>  8294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8294
aaaugaacuu ucauuuuugg                                                   20


<210>  8295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8295
ggacacagca gugaugccuu                                                   20


<210>  8296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8296
caccucggga cacagcagug                                                   20


<210>  8297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8297
uuagaaaagu cuggcauuua                                                   20


<210>  8298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8298
ggguguggug gugggcgccu                                                   20


<210>  8299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8299
acuaaaaaua caaaaaauuc                                                   20


<210>  8300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8300
aucuccugac cuugugaucc                                                   20


<210>  8301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8301
ugaccuugug auccaccugc                                                   20


<210>  8302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8302
gccucccaaa gugcugggau                                                   20


<210>  8303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8303
caaagugcug ggauuacaag                                                   20


<210>  8304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8304
cgcuuguaau cccagcacuu                                                   20


<210>  8305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8305
cacgcuugua aucccagcac                                                   20


<210>  8306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8306
aaaaaaaaaa aacagugucu                                                   20


<210>  8307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8307
agccugggca acaaaagcaa                                                   20


<210>  8308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8308
gcucccugaa ccuccagguu                                                   20


<210>  8309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8309
cugaaccucc agguucaggc                                                   20


<210>  8310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8310
agguucaggc gauuccccug                                                   20


<210>  8311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8311
gccucccgag uagcugggau                                                   20


<210>  8312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8312
cgaguagcug ggauuacagg                                                   20


<210>  8313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8313
ggaggcugag acaggggaau                                                   20


<210>  8314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8314
acuaaacaua caaaauuauc                                                   20


<210>  8315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8315
ggugauccgu ccgccuuggc                                                   20


<210>  8316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8316
caaagugcug ggauuacagg                                                   20


<210>  8317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8317
ugccuguaau cccagcacuu                                                   20


<210>  8318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8318
cuggccgggc acaguggcuc                                                   20


<210>  8319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8319
caagcagcua ggacuacagg                                                   20


<210>  8320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8320
gccucccaag cagcuaggac                                                   20


<210>  8321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8321
cagguucaag caauuauccc                                                   20


<210>  8322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8322
accucccagg uucaagcaau                                                   20


<210>  8323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8323
cugcaaccuc caccucccag                                                   20


<210>  8324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8324
gccacccagg cuggugugca                                                   20


<210>  8325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8325
cucugccacc caggcuggug                                                   20


<210>  8326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8326
aaaaauaaau aauuuuuaaa                                                   20


<210>  8327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8327
ugccuguaau cucagcacuu                                                   20


<210>  8328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8328
gcacuuuggg aggccgaagc                                                   20


<210>  8329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8329
caaagugcug agauuacagg                                                   20


<210>  8330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8330
agugauccac cagcuucggc                                                   20


<210>  8331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8331
caaccucaag ugauccacca                                                   20


<210>  8332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8332
auguugauca ggcuugucau                                                   20


<210>  8333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8333
acuaaaaaga caaaauuagc                                                   20


<210>  8334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8334
gauuccccag uagcuaggau                                                   20


<210>  8335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8335
ugccucagau uccccaguag                                                   20


<210>  8336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8336
uggguucaag ugauucuccu                                                   20


<210>  8337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8337
cuccuggguu caagugauuc                                                   20


<210>  8338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8338
cccuccuggg uucaagugau                                                   20


<210>  8339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8339
ggucacugca accucucccu                                                   20


<210>  8340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8340
agccugggca acaagagcaa                                                   20


<210>  8341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8341
uguugcccag gcuggagugc                                                   20


<210>  8342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8342
gucucaaaaa aaaaaauaua                                                   20


<210>  8343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8343
aaaaaaaaaa uauauauaua                                                   20


<210>  8344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8344
ugaccuuggg uaaagggaaa                                                   20


<210>  8345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8345
caccauacac aaaaaucaau                                                   20


<210>  8346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8346
aggauagaaa aguagacgaa                                                   20


<210>  8347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8347
cugaauuauu auagcauuug                                                   20


<210>  8348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8348
gaauuauuau agcauuuguu                                                   20


<210>  8349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8349
acaacaacaa augcuauaau                                                   20


<210>  8350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8350
guugcccagg cuggaaugca                                                   20


<210>  8351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8351
ugccacugca uuccagccug                                                   20


<210>  8352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8352
uuguagccuc aaccuccugg                                                   20


<210>  8353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8353
accuccuggg cucaagcaau                                                   20


<210>  8354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8354
ugggcucaag caaucuuccc                                                   20


<210>  8355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8355
agcaaucuuc ccaccucagc                                                   20


<210>  8356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8356
gccuccugag uggcugggac                                                   20


<210>  8357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8357
ugaguggcug ggacuacagg                                                   20


<210>  8358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8358
ggaggcugag gugggaagau                                                   20


<210>  8359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8359
acaaaaaauu uaaaaauaag                                                   20


<210>  8360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8360
cucuguugcu caggcggucu                                                   20


<210>  8361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8361
guugcucagg cggucuugaa                                                   20


<210>  8362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8362
ggcggucuug aacuccuggg                                                   20


<210>  8363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8363
ugggcucaag caacccuuuc                                                   20


<210>  8364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8364
agcaacccuu ucacccaagc                                                   20


<210>  8365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8365
caaagugcug ggauuacagg                                                   20


<210>  8366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8366
uguaauccca gcacuuuggg                                                   20


<210>  8367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8367
gccuaguaua gcuuuuuaau                                                   20


<210>  8368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8368
gguauuccuu auagcaacac                                                   20


<210>  8369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8369
ugguucugca agcuguguaa                                                   20


<210>  8370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8370
ccagaugcaa augcugugca                                                   20


<210>  8371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8371
caccagaugc aaaugcugug                                                   20


<210>  8372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8372
gguuuuuucc acuuacggca                                                   20


<210>  8373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8373
ucaccuugug ccguaagugg                                                   20


<210>  8374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8374
ucaugucauc uggacacacu                                                   20


<210>  8375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8375
caucauguca ucuggacaca                                                   20


<210>  8376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8376
ugcuuuuucu cucaucaugu                                                   20


<210>  8377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8377
cuugcuuuuu cucucaucau                                                   20


<210>  8378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8378
uuucccaucu cucuugcuuu                                                   20


<210>  8379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8379
cagggaacua auggaaugag                                                   20


<210>  8380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8380
gggaacuaau ggaaugagaa                                                   20


<210>  8381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8381
uuccauuagu ucccugagag                                                   20


<210>  8382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8382
cucagugcug gaaagacagc                                                   20


<210>  8383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8383
gugcuggaaa gacagcacca                                                   20


<210>  8384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8384
ugaauggcuu ggugcugucu                                                   20


<210>  8385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8385
ugacccaugc acuucccauu                                                   20


<210>  8386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8386
agcacugggu gugguggcac                                                   20


<210>  8387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8387
gcugcucagg agucugaggu                                                   20


<210>  8388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8388
ggagucugag gugaaaggau                                                   20


<210>  8389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8389
ugagcagcug agaccacagg                                                   20


<210>  8390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8390
gacuccugag cagcugagac                                                   20


<210>  8391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8391
agcgauccuu ucaccucaga                                                   20


<210>  8392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8392
aacuucuggg cucaagcgau                                                   20


<210>  8393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8393
ucucugcuaa aaauacaaaa                                                   20


<210>  8394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8394
gcuaaaaaua caaaaauuag                                                   20


<210>  8395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8395
gucugccaag uagcuggaac                                                   20


<210>  8396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8396
ugccucaguc ugccaaguag                                                   20


<210>  8397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8397
accacccggg cuaucaagug                                                   20


<210>  8398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8398
cugcaaccuc caccacccgg                                                   20


<210>  8399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8399
guugccuagg cuggacugca                                                   20


<210>  8400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8400
aaauauguaa auaaaagaaa                                                   20


<210>  8401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8401
uucuuuucaa aauuuuuuuc                                                   20


<210>  8402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8402
gaaggaauuc acugaaaagg                                                   20


<210>  8403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8403
cugccuaucu uuuccuuccu                                                   20


<210>  8404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8404
cacugccuau cuuuuccuuc                                                   20


<210>  8405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8405
guagcacuuc ugccccagcu                                                   20


<210>  8406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8406
caguagcacu ucugccccag                                                   20


<210>  8407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8407
ucucaguagc acuucugccc                                                   20


<210>  8408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8408
gaagaaacac aacgaucucc                                                   20


<210>  8409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8409
cacucugaag aaacacaacg                                                   20


<210>  8410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8410
uucuuuccug caucacuucc                                                   20


<210>  8411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8411
uaucaucacu uucucuuucu                                                   20


<210>  8412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8412
ucucauauca ucacuuucuc                                                   20


<210>  8413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8413
aguggcgaca gggugggguc                                                   20


<210>  8414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8414
ucacaaccag accccacccu                                                   20


<210>  8415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8415
aacuagcucu ucacaaccag                                                   20


<210>  8416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8416
aauguccucc aacuagcucu                                                   20


<210>  8417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8417
ccaauguccu ccaacuagcu                                                   20


<210>  8418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8418
ucuccaaugu ccuccaacua                                                   20


<210>  8419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8419
cacacauccg cagaccugcg                                                   20


<210>  8420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8420
caccacccuc agcagucugu                                                   20


<210>  8421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8421
gcagucugug aauacccauc                                                   20


<210>  8422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8422
ucagcacaga guccaugucc                                                   20


<210>  8423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8423
gcacagaguc caugucccug                                                   20


<210>  8424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8424
gugcugagga guauaaagga                                                   20


<210>  8425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8425
ugggcacccu gcuccgcauu                                                   20


<210>  8426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8426
gcauugacgg agcucgagau                                                   20


<210>  8427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8427
gucaaugcgg agcagggugc                                                   20


<210>  8428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8428
agauccccac aucuacucca                                                   20


<210>  8429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8429
agcuccguca augcggagca                                                   20


<210>  8430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8430
acugcucccc uuccucucaa                                                   20


<210>  8431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8431
ccuuccucuc aacuuccauc                                                   20


<210>  8432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8432
caacuuccau cauuaggcuc                                                   20


<210>  8433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8433
acuuccauca uuaggcucag                                                   20


<210>  8434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8434
gggaccuugg cccuuucccu                                                   20


<210>  8435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8435
uuaccuuaag ucgucuccuc                                                   20


<210>  8436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8436
ucaucuuuug acuuacaugg                                                   20


<210>  8437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8437
ucuuuugacu uacauggacc                                                   20


<210>  8438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8438
uucccauaau acaauguuga                                                   20


<210>  8439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8439
ccuucccaua auacaauguu                                                   20


<210>  8440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8440
gguuuggcug uccuuggguc                                                   20


<210>  8441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8441
cugcugccag gggagcacag                                                   20


<210>  8442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8442
ccuggcagca gggaggcauc                                                   20


<210>  8443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8443
uccaucacca ucaccugugc                                                   20


<210>  8444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8444
ccaucagcag aggugugggu                                                   20


<210>  8445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8445
gcugaugggg agguccccau                                                   20


<210>  8446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8446
aaauuaagug accugaagca                                                   20


<210>  8447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8447
gaauaaaagc cacuuucagc                                                   20


<210>  8448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8448
guucuauuua aguaguuuua                                                   20


<210>  8449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8449
cuggucauuu cuggguauug                                                   20


<210>  8450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8450
ggucauuucu ggguauugcu                                                   20


<210>  8451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8451
gaagguccug aaaaaucaca                                                   20


<210>  8452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8452
cacugcaguu uguaacccuu                                                   20


<210>  8453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8453
auacagcaaa agggcaaaac                                                   20


<210>  8454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8454
acauucaggc uccauacagc                                                   20


<210>  8455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8455
gucaugggac agcacaaaua                                                   20


<210>  8456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8456
gaacaugucu ggaugccagg                                                   20


<210>  8457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8457
gauauuuguu uucuucugga                                                   20


<210>  8458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8458
auguaauguu acuaaugugg                                                   20


<210>  8459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8459
ugaauugccc uauuaaaugg                                                   20


<210>  8460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8460
guuuauucua auauguaaac                                                   20


<210>  8461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8461
gaaggauuua cuuuuaauuu                                                   20


<210>  8462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8462
auaaaauuca acagugacug                                                   20


<210>  8463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8463
guaagauuac agaaauuauu                                                   20


<210>  8464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8464
gugauaaaua auuucuguaa                                                   20


<210>  8465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8465
ugauaugauu guuaccaauc                                                   20


<210>  8466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8466
uuguaaccac ugagaaggag                                                   20


<210>  8467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8467
gugguuacaa agagauuggu                                                   20


<210>  8468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8468
uucucagugg uuacaaagag                                                   20


<210>  8469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8469
ccaggcaaug ccuuuugcuc                                                   20


<210>  8470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8470
aggcaaugcc uuuugcucag                                                   20


<210>  8471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8471
gagaaccugc auaugcuuug                                                   20


<210>  8472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8472
gagcaaaagg cauugccugg                                                   20


<210>  8473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8473
gcuuucccaa agcauaugca                                                   20


<210>  8474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8474
aguccaggga acacuguuau                                                   20


<210>  8475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8475
caaagugcug ggauuacagg                                                   20


<210>  8476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8476
gccucccaaa gugcugggau                                                   20


<210>  8477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8477
ugaucugccu accucggccu                                                   20


<210>  8478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8478
aauuccugac cucgugaucu                                                   20


<210>  8479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8479
acuaaaaaua caaaaacuag                                                   20


<210>  8480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8480
ggaggcugag gcaggagaau                                                   20


<210>  8481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8481
ugaguagcug ggauuacaug                                                   20


<210>  8482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8482
gccuccugag uagcugggau                                                   20


<210>  8483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8483
ugccucagcc uccugaguag                                                   20


<210>  8484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8484
uggauucaag caauucuccu                                                   20


<210>  8485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8485
gccuccugga uucaagcaau                                                   20


<210>  8486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8486
uugcaaccuc cgccuccugg                                                   20


<210>  8487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8487
gcucauugca accuccgccu                                                   20


<210>  8488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8488
agccugggca acagagcgag                                                   20


<210>  8489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8489
guugcccagg cuggagugca                                                   20


<210>  8490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8490
cucuguugcc caggcuggag                                                   20


<210>  8491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8491
gucucaaaaa aaaaaaaaaa                                                   20


<210>  8492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8492
aaaaaaaaaa aaaagaaaga                                                   20


<210>  8493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8493
cgccuguaau cccagcacuu                                                   20


<210>  8494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8494
caaagugcug ggauuacagg                                                   20


<210>  8495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8495
gccucccaaa gugcugggau                                                   20


<210>  8496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8496
ugaucugccc gccucggccu                                                   20


<210>  8497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8497
ugaccucgug aucugcccgc                                                   20


<210>  8498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8498
aucuccugac cucgugaucu                                                   20


<210>  8499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8499
acuaacaacg ccugucuggg                                                   20


<210>  8500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8500
ugccuguagu cccagcuacu                                                   20


<210>  8501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8501
caaguagcug ggacuacagg                                                   20


<210>  8502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8502
gccucccaag uagcugggac                                                   20


<210>  8503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8503
ugccucagcc ucccaaguag                                                   20


<210>  8504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8504
ggaggcagag guugcaguga                                                   20


<210>  8505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8505
cgaguucaaa ugauccuccu                                                   20


<210>  8506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8506
gccucccgag uucaaaugau                                                   20


<210>  8507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8507
cugcaaccuc ugccucccga                                                   20


<210>  8508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8508
gucaccaggc uggaaugcag                                                   20


<210>  8509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8509
cucugucacc aggcuggaau                                                   20


<210>  8510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8510
aucucaaaaa aaaaaaacaa                                                   20


<210>  8511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8511
aaaaaaaaaa acaaaaaaaa                                                   20


<210>  8512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8512
aucacaauuu ucuguuuuuu                                                   20


<210>  8513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8513
acauuaugaa uguccauaau                                                   20


<210>  8514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8514
caccuguaau cccagcauug                                                   20


<210>  8515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8515
caaugcuggg auuacaggug                                                   20


<210>  8516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8516
cacaaugcug ggauuacagg                                                   20


<210>  8517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8517
gccucucaca augcugggau                                                   20


<210>  8518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8518
ugauccaccc gccucggccu                                                   20


<210>  8519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8519
ugaccucgug auccacccgc                                                   20


<210>  8520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8520
aucuccugac cucgugaucc                                                   20


<210>  8521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8521
acuaaaaaua caaaaaauua                                                   20


<210>  8522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8522
gccuaccaag uagcugggau                                                   20


<210>  8523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8523
ugccucagcc uaccaaguag                                                   20


<210>  8524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8524
cagguucaag ugauucuccu                                                   20


<210>  8525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8525
accucccagg uucaagugau                                                   20


<210>  8526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8526
gugcaaccuc caccucccag                                                   20


<210>  8527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8527
gcucagugca accuccaccu                                                   20


<210>  8528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8528
gugacccagg cuggggugua                                                   20


<210>  8529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8529
cucucaaaaa aaaaaaaaga                                                   20


<210>  8530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8530
caaaaaaaaa aaaagagugu                                                   20


<210>  8531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8531
aaaaaaaaaa aagaguguag                                                   20


<210>  8532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8532
uuuuuuuuuu uugagaggga                                                   20


<210>  8533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8533
uguacaacuu cuacacucuu                                                   20


<210>  8534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8534
aucaauacgu gucacacgca                                                   20


<210>  8535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8535
cuaccccuca aucaauacgu                                                   20


<210>  8536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8536
caguugucuu guaaaggaaa                                                   20


<210>  8537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8537
ccgccuuucc uuuacaagac                                                   20


<210>  8538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8538
uccugccuuc auacuugcug                                                   20


<210>  8539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8539
cgccccaacc aacuaugugg                                                   20


<210>  8540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8540
uuacaguucc acacucccgc                                                   20


<210>  8541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8541
gccuuaaacc cuucgauugu                                                   20


<210>  8542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8542
cacuguaccu augaccagaa                                                   20


<210>  8543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8543
ugucaaaacc cccucacacu                                                   20


<210>  8544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8544
aucuccuguc aaaacccccu                                                   20


<210>  8545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8545
ccacaugccc uccaucuccu                                                   20


<210>  8546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8546
ugccgaccgg ccuucagggc                                                   20


<210>  8547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8547
ugcauuagcc uucauagggc                                                   20


<210>  8548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8548
gguaacagca gcacaaccca                                                   20


<210>  8549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8549
cggguaacag cagcacaacc                                                   20


<210>  8550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8550
cacccccaug cacacaggcc                                                   20


<210>  8551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8551
gcuguuagua guguucccaa                                                   20


<210>  8552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8552
uaugcaaaaa uuucuggguu                                                   20


<210>  8553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8553
aaaaaaaaaa uuauauauau                                                   20


<210>  8554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8554
aucucaaaaa aaaaaauuau                                                   20


<210>  8555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8555
guuugcccag gcuggaaugc                                                   20


<210>  8556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8556
gccucauggg uucaagugau                                                   20


<210>  8557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8557
uggguucaag ugauucuccu                                                   20


<210>  8558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8558
ugccucagcu ugaguagcug                                                   20


<210>  8559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8559
gcuugaguag cugggauuac                                                   20


<210>  8560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8560
agcugaggca ggagaaucac                                                   20


<210>  8561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8561
ugaccucuug aucugccugc                                                   20


<210>  8562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8562
ugaucugccu gccucggccu                                                   20


<210>  8563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8563
gccucacaga guguugggau                                                   20


<210>  8564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8564
cagaguguug ggauuacagg                                                   20


<210>  8565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8565
gugaggccga ggcaggcaga                                                   20


<210>  8566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8566
caccuguaau cccaacacuc                                                   20


<210>  8567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8567
ugcuuggaag cagaaaucua                                                   20


<210>  8568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8568
aacagugaaa caaaggacca                                                   20


<210>  8569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8569
gggaucacug uccugccugc                                                   20


<210>  8570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8570
cagggaucac uguccugccu                                                   20


<210>  8571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8571
agccuugccc aggcuuccug                                                   20


<210>  8572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8572
aggcaggaag ccugggcaag                                                   20


<210>  8573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8573
ccaggcagga agccugggca                                                   20


<210>  8574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8574
cuccaggcag gaagccuggg                                                   20


<210>  8575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8575
aaguccuagc cuucagacuc                                                   20


<210>  8576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8576
ccaaguccua gccuucagac                                                   20


<210>  8577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8577
gucuggguag cucuccaagu                                                   20


<210>  8578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8578
gacucggucu ggguagcucu                                                   20


<210>  8579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8579
uugauugagg aggcugaguu                                                   20


<210>  8580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8580
aucaaggaga uccucagacu                                                   20


<210>  8581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8581
ucaaucaagg agauccucag                                                   20


<210>  8582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8582
gccuccucaa ucaaggagau                                                   20


<210>  8583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8583
acucagccuc cucaaucaag                                                   20


<210>  8584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8584
ccaaagucuc aacucagccu                                                   20


<210>  8585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8585
gcccugcaaa uuuacuuugg                                                   20


<210>  8586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8586
gguacucugc ccugcaaauu                                                   20


<210>  8587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8587
cugguacucu gcccugcaaa                                                   20


<210>  8588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8588
ucucugguac ucugcccugc                                                   20


<210>  8589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8589
ccucucuggu acucugcccu                                                   20


<210>  8590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8590
cuccucucug guacucugcc                                                   20


<210>  8591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8591
uugcagcucu cuccucucug                                                   20


<210>  8592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8592
uccuuccccu cuuugcagcu                                                   20


<210>  8593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8593
gcauaggguu cuccccaagc                                                   20


<210>  8594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8594
ccaagcccag cugagggcgc                                                   20


<210>  8595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8595
gcugggcuug gggagaaccc                                                   20


<210>  8596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8596
cugcgccugg gcuagcaccc                                                   20


<210>  8597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8597
gcgccugggc uagcacccug                                                   20


<210>  8598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8598
cuuccagggu gcuagcccag                                                   20


<210>  8599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8599
ucacuuccag ggugcuagcc                                                   20


<210>  8600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8600
cacagggcca ggagcagugu                                                   20


<210>  8601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8601
uggcccugug ugagcugcaa                                                   20


<210>  8602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8602
uaagcugcca cccagggucc                                                   20


<210>  8603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8603
guugugggua agaggaaagg                                                   20


<210>  8604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8604
uacccacaac ugaggcaaua                                                   20


<210>  8605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8605
guaaggcagc aucagaacgc                                                   20


<210>  8606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8606
ucccaaacaa cccuccuaug                                                   20


<210>  8607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8607
uauggcccau gacgaagcuc                                                   20


<210>  8608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8608
gauacugaag gaaugaaaaa                                                   20


<210>  8609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8609
ucuccuccuc ucacaccuca                                                   20


<210>  8610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8610
uccucucaca ccucacagcu                                                   20


<210>  8611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8611
ucucacaccu cacagcuggc                                                   20


<210>  8612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8612
cacaccucac agcuggcucc                                                   20


<210>  8613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8613
caccucacag cuggcuccuu                                                   20


<210>  8614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8614
cagcuggcuc cuucacagcc                                                   20


<210>  8615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8615
uucacagccu uauccacuuc                                                   20


<210>  8616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8616
ugaacugcag auagucguuu                                                   20


<210>  8617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8617
cucugcacgc agccucagag                                                   20


<210>  8618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8618
cugcacgcag ccucagaguc                                                   20


<210>  8619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8619
gcacgcagcc ucagagucac                                                   20


<210>  8620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8620
gagucacucc uugacuucag                                                   20


<210>  8621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8621
gaggcugcgu gcagagagag                                                   20


<210>  8622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8622
uugacuucag uggcccucag                                                   20


<210>  8623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8623
gcucuccccc aucucuccuu                                                   20


<210>  8624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8624
cccccaucuc uccuucugcu                                                   20


<210>  8625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8625
cccaucucuc cuucugcucu                                                   20


<210>  8626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8626
ccuucugcuc uugucagccc                                                   20


<210>  8627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8627
uucugcucuu gucagcccca                                                   20


<210>  8628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8628
ugucagcccc augccagcca                                                   20


<210>  8629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8629
ccacaaggua cagccauguc                                                   20


<210>  8630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8630
ucaaggaggc ccucacuguc                                                   20


<210>  8631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8631
aggaggcccu cacuguccac                                                   20


<210>  8632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8632
uugaggagac ccccgaagcc                                                   20


<210>  8633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8633
cuguccaccg gguuaaaggg                                                   20


<210>  8634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8634
uuaucacuau uuaauuaguu                                                   20


<210>  8635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8635
gugccuggac cagucccuga                                                   20


<210>  8636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8636
gggacugguc caggcacuga                                                   20


<210>  8637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8637
guaaauccug gaugacuggu                                                   20


<210>  8638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8638
uguacauuca ccagucaucc                                                   20


<210>  8639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8639
gcuccuguac auucaccagu                                                   20


<210>  8640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8640
cuggucauuu cuggcucuua                                                   20


<210>  8641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8641
ggucauuucu ggcucuuaac                                                   20


<210>  8642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8642
uaacauuaug auuuuaggcu                                                   20


<210>  8643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8643
acaggcccaa agguccccaa                                                   20


<210>  8644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8644
uucuguaauu aaaagggcaa                                                   20


<210>  8645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8645
caucacuggc agaacagcca                                                   20


<210>  8646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8646
ggucuuagaa aacagcuccc                                                   20


<210>  8647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8647
uuuccucagg ucuuagaaaa                                                   20


<210>  8648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8648
ugguacucgg ugguuugagu                                                   20


<210>  8649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8649
gugguuugag uagucuggcg                                                   20


<210>  8650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8650
aaccaccgag uaccaugaga                                                   20


<210>  8651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8651
aggacacugu ggggagguag                                                   20


<210>  8652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8652
ccacaguguc cuagagaacg                                                   20


<210>  8653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8653
ggauggcugc ugagcugggu                                                   20


<210>  8654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8654
gcagccaucc ugagcugaau                                                   20


<210>  8655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8655
caacccugug gauguaacag                                                   20


<210>  8656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8656
uguuacaucc acaggguugu                                                   20


<210>  8657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8657
cauguuucca ugaaccagug                                                   20


<210>  8658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8658
aaagauguuc auauauauuc                                                   20


<210>  8659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8659
auucuuaaga cuuccugcug                                                   20


<210>  8660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8660
uuuggacccc aggcuccauu                                                   20


<210>  8661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8661
cauuuggacc ccaggcucca                                                   20


<210>  8662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8662
guggcuguuc aggggccaau                                                   20


<210>  8663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8663
ccaucccacc accgguauuc                                                   20


<210>  8664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8664
aggcuguggg aagagcuaca                                                   20


<210>  8665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8665
agcugucucc ccaucccacc                                                   20


<210>  8666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8666
ucccacagcc ucgagcuguc                                                   20


<210>  8667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8667
aaggccggcu agaccuguag                                                   20


<210>  8668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8668
acccagaagc uucuccaagg                                                   20


<210>  8669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8669
aucuccaccc agaagcuucu                                                   20


<210>  8670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8670
cuucccaccu ggcaugucuu                                                   20


<210>  8671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8671
ucccaccugg caugucuugc                                                   20


<210>  8672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8672
ugccguguag gguguccuug                                                   20


<210>  8673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8673
ccugccgugu aggguguccu                                                   20


<210>  8674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8674
caccuccacc ccacugugug                                                   20


<210>  8675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8675
ccuccacccc acugugugcc                                                   20


<210>  8676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8676
accccacugu gugcccuuuu                                                   20


<210>  8677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8677
ggaaggccag gcgaggcuuc                                                   20


<210>  8678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8678
ccuggccuuc cagaggcagc                                                   20


<210>  8679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8679
cugggagugc cucccuccag                                                   20


<210>  8680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8680
cagggagcag ggcaaaggga                                                   20


<210>  8681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8681
cuccagccuc uccucagggu                                                   20


<210>  8682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8682
agccucuccu caggguucga                                                   20


<210>  8683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8683
ccucaggguu cgaaggggcu                                                   20


<210>  8684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8684
ucaggguucg aaggggcuuc                                                   20


<210>  8685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8685
ggguucgaag gggcuuccuc                                                   20


<210>  8686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8686
uaaggugcag aggcagcccu                                                   20


<210>  8687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8687
gcaccuuagg aggaagcccc                                                   20


<210>  8688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8688
cccgacacac acacacuugc                                                   20


<210>  8689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8689
cacaacugga aaugggguua                                                   20


<210>  8690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8690
guuucuuucu uuuucuuuuc                                                   20


<210>  8691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8691
aaaaaaaaaa aaaaaaaaaa                                                   20


<210>  8692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8692
auugcccagg cuggaaugca                                                   20


<210>  8693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8693
cugcaaccuc caccuuccag                                                   20


<210>  8694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8694
accuuccagg uucaaacgau                                                   20


<210>  8695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8695
ugcgucagcc uccugaguag                                                   20


<210>  8696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8696
ugaguagcug ggauuacagg                                                   20


<210>  8697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8697
ggaggcugac gcaggagaau                                                   20


<210>  8698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8698
cacccaggcu agagugcagu                                                   20


<210>  8699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8699
cccaggcuag agugcagugg                                                   20


<210>  8700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8700
agccugggug agagggcaag                                                   20


<210>  8701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8701
cuacagccuc gacuugcugg                                                   20


<210>  8702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8702
acuugcuggg uuuuagcaau                                                   20


<210>  8703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8703
caccucagcc ucccuaguag                                                   20


<210>  8704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8704
ccucagccuc ccuaguagcu                                                   20


<210>  8705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8705
gccucccuag uagcugggac                                                   20


<210>  8706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8706
cuaguagcug ggacuacagg                                                   20


<210>  8707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8707
gcaaaaaauc caacuauuag                                                   20


<210>  8708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8708
guaacauagc aagacuucgc                                                   20


<210>  8709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8709
aaccucugag cucaaaugau                                                   20


<210>  8710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8710
gagcucaaau gaucaucuca                                                   20


<210>  8711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8711
gagguuugag accagccuca                                                   20


<210>  8712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8712
aaugaucauc ucaccucugc                                                   20


<210>  8713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8713
ccucugccuc cccaggugcu                                                   20


<210>  8714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8714
gccuccccag gugcugggau                                                   20


<210>  8715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8715
ccaggugcug ggaucacagg                                                   20


<210>  8716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8716
aucagaaaaa aaauaaaauu                                                   20


<210>  8717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8717
aaagauaacc acccacucua                                                   20


<210>  8718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8718
caaaagauaa ccacccacuc                                                   20


<210>  8719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8719
uaccucuaag gccucuuccc                                                   20


<210>  8720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8720
aaggccucuu ccccuugccc                                                   20


<210>  8721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8721
uccccuugcc ccacauugua                                                   20


<210>  8722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8722
uaucaccuga uguaaauaaa                                                   20


<210>  8723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8723
ucucuuauca ccugauguaa                                                   20


<210>  8724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8724
gcaucauuac ugcugggccu                                                   20


<210>  8725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8725
cuguuuaucu ugaaucugga                                                   20


<210>  8726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8726
aagaugguuu gcaucugcag                                                   20


<210>  8727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8727
gauucaagau ggcaauucug                                                   20


<210>  8728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8728
agaauaguag uuucagacuu                                                   20


<210>  8729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8729
auuuucagac uguuuaccag                                                   20


<210>  8730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8730
cagugacacc ccagugccca                                                   20


<210>  8731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8731
ugcguguccc ucccagugac                                                   20


<210>  8732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8732
cucacgggcg agaacuaagc                                                   20


<210>  8733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8733
cgggcgagaa cuaagcaccu                                                   20


<210>  8734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8734
cccgugagug agguagcgug                                                   20


<210>  8735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8735
ucccggggcc gcggaggcca                                                   20


<210>  8736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8736
gcggccccgg gacgaggccc                                                   20


<210>  8737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8737
gggugggcgg ggaacugcac                                                   20


<210>  8738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8738
gaccuccagg auugcgggac                                                   20


<210>  8739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8739
aggauugcgg gacccgccgg                                                   20


<210>  8740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8740
ccggcggguc ccgcaauccu                                                   20


<210>  8741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8741
uggccccgcc ccggccccgc                                                   20


<210>  8742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8742
uccuggcccc gccccggccc                                                   20


<210>  8743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8743
gucccgcccg cgcccgccca                                                   20


<210>  8744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8744
cgcccgcggg acccgccgcc                                                   20


<210>  8745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8745
gccgccaggc gcucccgccc                                                   20


<210>  8746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8746
acccagggcc cgcgggccag                                                   20


<210>  8747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8747
uggcccgcgg gcccuggguc                                                   20


<210>  8748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8748
ccuggcccgc gggcccuggg                                                   20


<210>  8749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8749
gcggguaagc cucggcggcg                                                   20


<210>  8750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8750
gcggcggguc ucggcggguc                                                   20


<210>  8751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8751
gcgggucucg ggggucucgc                                                   20


<210>  8752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8752
ggggucucgc gggggggcgg                                                   20


<210>  8753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8753
cgggggggcg gucuccgcgu                                                   20


<210>  8754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8754
gcgucuggaa ggggcucggc                                                   20


<210>  8755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8755
gcgggccuug gcggucuggg                                                   20


<210>  8756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8756
cggcgggucu cgggggucuc                                                   20


<210>  8757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8757
gcgggucucg ggggucucgg                                                   20


<210>  8758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8758
ggggucucgg gggagucucg                                                   20


<210>  8759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8759
ggggagucuc ggggucccga                                                   20


<210>  8760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8760
cccgagaccc ccgagacccg                                                   20


<210>  8761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8761
gggucccgac aggucucggc                                                   20


<210>  8762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8762
gcgggucucg ggggucucgg                                                   20


<210>  8763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8763
ggggucucgg gggagucucc                                                   20


<210>  8764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8764
ggggagucuc cggggagucu                                                   20


<210>  8765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8765
cccgagaccc ccgagacccg                                                   20


<210>  8766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8766
ggggagucuc aggggucccg                                                   20


<210>  8767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8767
ccggagacuc ccccgagacc                                                   20


<210>  8768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8768
ggggucccgg caggucuugg                                                   20


<210>  8769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8769
ggggagucuc agggucccgg                                                   20


<210>  8770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8770
cccgagaccu gccaagaccu                                                   20


<210>  8771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8771
gggucccggc agguaugggc                                                   20


<210>  8772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8772
ggugcgcagc agccuccccc                                                   20


<210>  8773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8773
cccgggcccc ggggccuccg                                                   20


<210>  8774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8774
guguccuugc caaaggacgc                                                   20


<210>  8775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8775
ggcacugccc gccgugccca                                                   20


<210>  8776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8776
cucgggcacu gcccgccgug                                                   20


<210>  8777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8777
ggggugggag gcggugcgac                                                   20


<210>  8778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8778
caccccugag cccccggcaa                                                   20


<210>  8779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8779
cgccccucug gccccgcggc                                                   20


<210>  8780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8780
ggccccgcgg cggggccccu                                                   20


<210>  8781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8781
ccacaagacu caaaggcugc                                                   20


<210>  8782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8782
aaggcugcgg cgggcacucg                                                   20


<210>  8783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8783
cucuccgccc uucccggaau                                                   20


<210>  8784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8784
ccgcccuucc cggaauccaa                                                   20


<210>  8785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8785
gcccuucccg gaauccaaac                                                   20


<210>  8786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8786
gcagcggccg cgcuucacgg                                                   20


<210>  8787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8787
gugaagcgcg gccgcugcag                                                   20


<210>  8788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8788
cacuucagug ugaaucagcg                                                   20


<210>  8789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8789
gacgcccggc uaucagucac                                                   20


<210>  8790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8790
caugggcaac agggaaucuc                                                   20


<210>  8791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8791
ugggcaacag ggaaucucag                                                   20


<210>  8792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8792
gggguggcag agggacugga                                                   20


<210>  8793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8793
gccaccccug agauucccug                                                   20


<210>  8794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8794
agucccucug ccaccccuga                                                   20


<210>  8795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8795
uccagucccu cugccacccc                                                   20


<210>  8796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8796
cugcagccca gcacuuuccc                                                   20


<210>  8797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8797
gggccucggc ucccuggggg                                                   20


<210>  8798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8798
gcucccuggg gguauugagg                                                   20


<210>  8799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8799
cuggggguau ugagggccug                                                   20


<210>  8800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8800
auacccccag ggagccgagg                                                   20


<210>  8801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8801
ggcccucaau acccccaggg                                                   20


<210>  8802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8802
ccacagcagg gcucaggccc                                                   20


<210>  8803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8803
uuuccgugag caccuccuau                                                   20


<210>  8804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8804
cggaaaggag caccagcaga                                                   20


<210>  8805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8805
uauccccucu cugugccuca                                                   20


<210>  8806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8806
cugugccuca guuugcucau                                                   20


<210>  8807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8807
gugccucagu uugcucaucu                                                   20


<210>  8808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8808
guuugcucau cuguugacac                                                   20


<210>  8809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8809
ucuguugaca cuggggacag                                                   20


<210>  8810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8810
uggucuagug gccacacuua                                                   20


<210>  8811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8811
gugugggcug cuggggugga                                                   20


<210>  8812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8812
uccuugccga agcaagccuc                                                   20


<210>  8813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8813
uugccgaagc aagccucugg                                                   20


<210>  8814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8814
ggguucaggu cagcccugca                                                   20


<210>  8815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8815
augagccugg acaagcuccu                                                   20


<210>  8816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8816
uggaguuggu gcagggcuga                                                   20


<210>  8817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8817
ugcccucacu ggcucaggcc                                                   20


<210>  8818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8818
cuggcucagg cccuguggga                                                   20


<210>  8819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8819
ggcccugugg gaccagagga                                                   20


<210>  8820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8820
ggucccacag ggccugagcc                                                   20


<210>  8821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8821
ucugguccca cagggccuga                                                   20


<210>  8822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8822
acccccuccu gguucuuccc                                                   20


<210>  8823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8823
ugguucuucc cacucugucc                                                   20


<210>  8824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8824
guccacuguc uccucuacgu                                                   20


<210>  8825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8825
ucuacguaga caccgucgaa                                                   20


<210>  8826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8826
acguagacac cgucgaaggg                                                   20


<210>  8827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8827
uggagcccaa ccucagggcc                                                   20


<210>  8828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8828
aagagggccc uucgacggug                                                   20


<210>  8829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8829
gggccccacu ccaggcacuc                                                   20


<210>  8830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8830
aggcacucca cuccuggcag                                                   20


<210>  8831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8831
acuccuggca ggacaggagg                                                   20


<210>  8832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8832
uggcaggaca ggaggccugg                                                   20


<210>  8833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8833
uguccugcca ggaguggagu                                                   20


<210>  8834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8834
ucccaggccu ccuguccugc                                                   20


<210>  8835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8835
cuugcagccc ucgucccagg                                                   20


<210>  8836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8836
cucccuugca gcccucgucc                                                   20


<210>  8837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8837
cccugccacc cgccaggcuc                                                   20


<210>  8838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8838
cugccacccg ccaggcuccc                                                   20


<210>  8839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8839
cuuugccugg cucugugccc                                                   20


<210>  8840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8840
gugcccugcg uuaggcacac                                                   20


<210>  8841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8841
agggugugcc uaacgcaggg                                                   20


<210>  8842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8842
ccagauggcc cuggcuggca                                                   20


<210>  8843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8843
caccagaugg cccuggcugg                                                   20


<210>  8844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8844
cugaaaggcc agguccccug                                                   20


<210>  8845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8845
aggaucaugg gggagcccac                                                   20


<210>  8846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8846
cccaugaucc uggaggccug                                                   20


<210>  8847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8847
uuggugggcu cccccaugau                                                   20


<210>  8848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8848
ucaggccagc cuccuuggug                                                   20


<210>  8849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8849
gucugccucu ucaggccagc                                                   20


<210>  8850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8850
cucugucugc cucuucaggc                                                   20


<210>  8851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8851
gggccugccu uggcccuuuc                                                   20


<210>  8852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8852
guccaugugg gcagaaaggg                                                   20


<210>  8853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8853
gcacccugcu uccucugucc                                                   20


<210>  8854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8854
agcugacuca gcacccugcu                                                   20


<210>  8855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8855
ccacccccca gggaugcacg                                                   20


<210>  8856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8856
gggccccugg acuucccguc                                                   20


<210>  8857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8857
cugggccccu ggacuucccg                                                   20


<210>  8858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8858
ucucucuggg ccccuggacu                                                   20


<210>  8859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8859
ggaaccaagg cuggccaucu                                                   20


<210>  8860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8860
cugccccuca ggaaccaagg                                                   20


<210>  8861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8861
gccaggaucu ugggugugaa                                                   20


<210>  8862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8862
gaugccacca guuuccagcu                                                   20


<210>  8863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8863
uggccaugau cacacagcug                                                   20


<210>  8864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8864
guuuucucau ccaugaccug                                                   20


<210>  8865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8865
uccaugaccu gagggcugug                                                   20


<210>  8866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8866
ggucauggau gagaaaacgg                                                   20


<210>  8867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8867
uagccaccca ccagguacaa                                                   20


<210>  8868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8868
gcgacccacu gucacugaau                                                   20


<210>  8869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8869
cccugguccu cagggccgcu                                                   20


<210>  8870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8870
cugguccuca gggccgcugu                                                   20


<210>  8871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8871
gggccgcugu auguccuguu                                                   20


<210>  8872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8872
aggccagucc cugcccccac                                                   20


<210>  8873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8873
ccaggccagu cccugccccc                                                   20


<210>  8874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8874
cagguuccug cccacauugg                                                   20


<210>  8875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8875
ggccuuaguc caaugugggc                                                   20


<210>  8876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8876
ugauggacuc aggccuuagu                                                   20


<210>  8877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8877
aaagcucccu uguggggaca                                                   20


<210>  8878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8878
cuugugggga caccccaggu                                                   20


<210>  8879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8879
gcccuccuca cucucugucc                                                   20


<210>  8880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8880
ucacucucug uccucucuug                                                   20


<210>  8881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8881
cucucugucc ucucuugacc                                                   20


<210>  8882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8882
cuguccucuc uugaccucau                                                   20


<210>  8883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8883
guccucucuu gaccucauga                                                   20


<210>  8884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8884
cuugaccuca ugaucugccc                                                   20


<210>  8885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8885
ugaccucaug aucugcccac                                                   20


<210>  8886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8886
ugaucugccc accucccaaa                                                   20


<210>  8887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8887
caaagugcug ggauuacagg                                                   20


<210>  8888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8888
cgccuguaau cccagcacuu                                                   20


<210>  8889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8889
gccaggcgug ggggcucacg                                                   20


<210>  8890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8890
cccacccagg cugcacagug                                                   20


<210>  8891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8891
ucacccaccc aggcugcaca                                                   20


<210>  8892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8892
ccuuguggca aauuccccgu                                                   20


<210>  8893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8893
caccuugugg caaauucccc                                                   20


<210>  8894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8894
acugcgucug ggguaggaca                                                   20


<210>  8895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8895
caccccucgg gccaaugaau                                                   20


<210>  8896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8896
ggccaaugaa uacagggugg                                                   20


<210>  8897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8897
ugacggccca cccuguauuc                                                   20


<210>  8898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8898
uccugacggc ccacccugua                                                   20


<210>  8899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8899
gaucccuccu ccugacggcc                                                   20


<210>  8900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8900
cuaccgcccg ccuuuggcuu                                                   20


<210>  8901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8901
cacccucccu accgcccgcc                                                   20


<210>  8902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8902
cgucaaacug gucucccacc                                                   20


<210>  8903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8903
ccacaccugg caugcaaagg                                                   20


<210>  8904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8904
auacccucac cacaccuggc                                                   20


<210>  8905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8905
caggccccuc cauacccuca                                                   20


<210>  8906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8906
uugccuccca ggccccucca                                                   20


<210>  8907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8907
aggauaggcg gcuccucccc                                                   20


<210>  8908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8908
uccccagaag gccucugcau                                                   20


<210>  8909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8909
ccagaaggcc ucugcauucu                                                   20


<210>  8910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8910
gcauucuucu gguggcccug                                                   20


<210>  8911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8911
guguccagac agggccacca                                                   20


<210>  8912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8912
agccccucgg uguccagaca                                                   20


<210>  8913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8913
gggacuuagg cagcccacac                                                   20


<210>  8914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8914
cuaccacccc cucugggacu                                                   20


<210>  8915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8915
cuggcuggcc cccuucccug                                                   20


<210>  8916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8916
ucaccacccc uuggccugug                                                   20


<210>  8917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8917
ccaccccuug gccugugcac                                                   20


<210>  8918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8918
cgugcacagg ccaaggggug                                                   20


<210>  8919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8919
uggcaccauc cugucuaccc                                                   20


<210>  8920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8920
gccacgggcc aggagaccug                                                   20


<210>  8921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8921
uggcccgugg cugagggcca                                                   20


<210>  8922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8922
ggucuccugg cccguggcug                                                   20


<210>  8923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8923
guuuccugau cugcaaaacg                                                   20


<210>  8924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8924
ggaccacgcu gcuggauuug                                                   20


<210>  8925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8925
uccuucaagg gugacgcgag                                                   20


<210>  8926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8926
cgucacccuu gaaggaugag                                                   20


<210>  8927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8927
cgcgucaccc uugaaggaug                                                   20


<210>  8928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8928
acccgccccg aaccugggca                                                   20


<210>  8929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8929
ugucugaccc aggucuccac                                                   20


<210>  8930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8930
aacuccuguc ugacccaggu                                                   20


<210>  8931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8931
caggagggga gaaaggugcc                                                   20


<210>  8932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8932
ugggagccug caccaccucg                                                   20


<210>  8933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8933
ccuccuggga gccugcacca                                                   20


<210>  8934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8934
cccaaccuuc ucucuucucc                                                   20


<210>  8935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8935
cuucucccca ggcucuguaa                                                   20


<210>  8936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8936
ucuccccagg cucuguaacu                                                   20


<210>  8937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8937
ccaggcucug uaacuuccaa                                                   20


<210>  8938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8938
guaacuucca aggccaugag                                                   20


<210>  8939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8939
uggccuugga aguuacagag                                                   20


<210>  8940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8940
cauggccuug gaaguuacag                                                   20


<210>  8941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8941
gggcguuggg gccagcaguu                                                   20


<210>  8942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8942
gggaagaaug ugggcucggc                                                   20


<210>  8943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8943
gccaccugga gcaguugccu                                                   20


<210>  8944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8944
agguggccga gcccacauuc                                                   20


<210>  8945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8945
ccaggcaacu gcuccaggug                                                   20


<210>  8946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8946
gaucucccca ggcaacugcu                                                   20


<210>  8947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8947
ucugaucucc ccaggcaacu                                                   20


<210>  8948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8948
gggcuccucu gaucucccca                                                   20


<210>  8949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8949
gccaaccccu cagggcuccu                                                   20


<210>  8950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8950
ugguauccau acccccaucc                                                   20


<210>  8951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8951
gcuacaggga uggggguaug                                                   20


<210>  8952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8952
gcuuccuugu gaaucagaug                                                   20


<210>  8953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8953
ugcugagccu gcuccaggca                                                   20


<210>  8954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8954
gcaggagcgc aguaaacauc                                                   20


<210>  8955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8955
aggcagcugg guggggcgua                                                   20


<210>  8956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8956
agccugcaga gggaggccag                                                   20


<210>  8957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8957
gcaggcuuga gcagacaggc                                                   20


<210>  8958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8958
cucugcaggc uugagcagac                                                   20


<210>  8959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8959
ccaccccagg gucagccagg                                                   20


<210>  8960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8960
agaaggcagu gugcgugcca                                                   20


<210>  8961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8961
gccccgugug ccauggcacg                                                   20


<210>  8962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8962
cggccucagc cccgugugcc                                                   20


<210>  8963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8963
gccccugccu cgcggccuca                                                   20


<210>  8964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8964
gugccgcuuc ccucggcccc                                                   20


<210>  8965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8965
caggcaccag aggggagcug                                                   20


<210>  8966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8966
ggcaccagag gggagcugag                                                   20


<210>  8967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8967
ggugccugag agaagcucug                                                   20


<210>  8968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8968
ccucuggugc cugagagaag                                                   20


<210>  8969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8969
gcuccccucu ggugccugag                                                   20


<210>  8970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8970
gagcaggcuu cgucugaggg                                                   20


<210>  8971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8971
gagcccagaa cucagcuccc                                                   20


<210>  8972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8972
gacgaagccu gcucugagcc                                                   20


<210>  8973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8973
uugugaaaug gggugaaagu                                                   20


<210>  8974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8974
ugggaggcca gauccccagg                                                   20


<210>  8975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8975
caugaguuag accuacuuuc                                                   20


<210>  8976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8976
ggccugggga ucuggccucc                                                   20


<210>  8977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8977
cugcccuuga cacuguguga                                                   20


<210>  8978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8978
guuuggggga guuccuucag                                                   20


<210>  8979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8979
cccaaacgga gcugcccauu                                                   20


<210>  8980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8980
auccaggggu guuguaaucu                                                   20


<210>  8981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8981
ucuguggcau uugagggucc                                                   20


<210>  8982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8982
aaugccacag aagagcauca                                                   20


<210>  8983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8983
ggacagugga cagggcugca                                                   20


<210>  8984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8984
cagaaugacc ccugaucccu                                                   20


<210>  8985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8985
gccuugggag ucuggggcag                                                   20


<210>  8986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8986
caaggcugag aaaaagccaa                                                   20


<210>  8987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8987
ggggcagugg uggaccuccu                                                   20


<210>  8988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8988
uucagaaggc ugcugcccag                                                   20


<210>  8989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8989
ugcaacacug ggugccugug                                                   20


<210>  8990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8990
ugcagugcau gccuagccca                                                   20


<210>  8991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8991
gaccuguggc cugucugcuc                                                   20


<210>  8992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8992
ccugccuggc ccaccuugcc                                                   20


<210>  8993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8993
cucccuuaga agcaauuuca                                                   20


<210>  8994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8994
cccuuagaag caauuucagc                                                   20


<210>  8995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8995
cuuagaagca auuucagcug                                                   20


<210>  8996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8996
ggguacccuc ccuggccacc                                                   20


<210>  8997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8997
cuggccaccc ccaacuccac                                                   20


<210>  8998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8998
acccugagcu gggugccuuc                                                   20


<210>  8999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  8999
ggguggaguu ggggguggcc                                                   20


<210>  9000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9000
ggaaggcacc cagcucaggg                                                   20


<210>  9001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9001
ugcuugggaa cucaggaagg                                                   20


<210>  9002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9002
ggaaggucag ggucgcgucu                                                   20


<210>  9003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9003
gacgcgaccc ugaccuuccu                                                   20


<210>  9004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9004
cagacgcgac ccugaccuuc                                                   20


<210>  9005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9005
gggacaggcc cacgugggca                                                   20


<210>  9006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9006
cccuuccucu gggacaggcc                                                   20


<210>  9007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9007
ccucacccuu ccucugggac                                                   20


<210>  9008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9008
cccagccucc cacuccuggg                                                   20


<210>  9009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9009
cagccuccca cuccugggca                                                   20


<210>  9010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9010
cacuccuggg cagggaagug                                                   20


<210>  9011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9011
ugggcaggga aguggcgcgg                                                   20


<210>  9012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9012
uugaaggugg cuugucacuc                                                   20


<210>  9013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9013
ccccaccugu guuuaacucu                                                   20


<210>  9014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9014
acugagcauc agagccuaau                                                   20


<210>  9015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9015
guagaguuaa acacaggugg                                                   20


<210>  9016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9016
gaugcucagu agaguuaaac                                                   20


<210>  9017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9017
accaacuggg cggcagcugc                                                   20


<210>  9018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9018
cacgaaacuc uucagguuuc                                                   20


<210>  9019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9019
ucagguuucc aucacagccu                                                   20


<210>  9020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9020
ucccuucccc cugcgggcug                                                   20


<210>  9021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9021
cuucccccug cgggcugcgc                                                   20


<210>  9022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9022
guggcccugg cagcgguaga                                                   20


<210>  9023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9023
cuaucuaccg cugccagggc                                                   20


<210>  9024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9024
ccaggcuuug guccucccua                                                   20


<210>  9025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9025
uccucaccag gcuuuggucc                                                   20


<210>  9026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9026
gcggcucuuc cucaccaggc                                                   20


<210>  9027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9027
gcucggcggc ucuuccucac                                                   20


<210>  9028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9028
cccugaacga aagugcuuuc                                                   20


<210>  9029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9029
cugaacgaaa gugcuuucuu                                                   20


<210>  9030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9030
guagcugcuc uuccuaaacg                                                   20


<210>  9031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9031
uccuaaacgu guguuggcuu                                                   20


<210>  9032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9032
agccaacaca cguuuaggaa                                                   20


<210>  9033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9033
aaucucaagc caacacacgu                                                   20


<210>  9034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9034
uugggaccca aagcccuggu                                                   20


<210>  9035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9035
ggugccagcu cuuugggacc                                                   20


<210>  9036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9036
ccauuaggag ggcaaugggg                                                   20


<210>  9037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9037
uaauggugag aaauccggcc                                                   20


<210>  9038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9038
caggccagcu uuucuggauc                                                   20


<210>  9039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9039
gggcucccag gccagcuuuu                                                   20


<210>  9040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9040
augcagggcu guguaccccc                                                   20


<210>  9041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9041
gagccagagg aggcaggcca                                                   20


<210>  9042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9042
gagccugguc uccaugcagg                                                   20


<210>  9043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9043
ggcucugagc cuggucucca                                                   20


<210>  9044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9044
ucuggcucug agccuggucu                                                   20


<210>  9045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9045
gcacucaucu ccucucucgg                                                   20


<210>  9046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9046
ucuccucucu cggaaacgcc                                                   20


<210>  9047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9047
ucucucggaa acgccccucc                                                   20


<210>  9048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9048
cucggaaacg ccccucccug                                                   20


<210>  9049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9049
cggaaacgcc ccucccugac                                                   20


<210>  9050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9050
gaaacgcccc ucccugaccc                                                   20


<210>  9051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9051
cugaccccag cugcuuccuc                                                   20


<210>  9052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9052
ccuccuacuc gaggccagaa                                                   20


<210>  9053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9053
uccuacucga ggccagaaag                                                   20


<210>  9054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9054
uacucgaggc cagaaaggga                                                   20


<210>  9055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9055
aggccagaaa gggaagcccc                                                   20


<210>  9056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9056
aguaggagga gaggaagcag                                                   20


<210>  9057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9057
ccccacugga aaggggcuuc                                                   20


<210>  9058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9058
ggcagcgcca gccacucacc                                                   20


<210>  9059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9059
gcugaccacu gaucugccug                                                   20


<210>  9060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9060
cucugcugac cacugaucug                                                   20


<210>  9061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9061
gcccugguca aacucacucu                                                   20


<210>  9062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9062
ggggaugcac ccccgucauc                                                   20


<210>  9063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9063
uguggccuca ggcguuccca                                                   20


<210>  9064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9064
ggcguuccca ggcugagacc                                                   20


<210>  9065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9065
gccugggaac gccugaggcc                                                   20


<210>  9066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9066
aggaacacag gugcugggug                                                   20


<210>  9067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9067
gguggcucca ccaggccagg                                                   20


<210>  9068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9068
accaggccag gccgugugac                                                   20


<210>  9069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9069
gccuucucug ggcagggcag                                                   20


<210>  9070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9070
gggcagggca gggacaggaa                                                   20


<210>  9071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9071
ugggaugcgu gagggugagg                                                   20


<210>  9072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9072
cgcaucccau gaggcugcac                                                   20


<210>  9073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9073
cccucacgca ucccaugagg                                                   20


<210>  9074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9074
cacacacccc gccccagcag                                                   20


<210>  9075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9075
uggggggcca cucccacaca                                                   20


<210>  9076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9076
aaagccggcg ucaggucauc                                                   20


<210>  9077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9077
augaccugac gccggcuuug                                                   20


<210>  9078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9078
gggcugauua ggacuaaugg                                                   20


<210>  9079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9079
ggggugcagc cucagccucc                                                   20


<210>  9080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9080
gccuccaccc gccacccgua                                                   20


<210>  9081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9081
acccgccacc cguacccgcc                                                   20


<210>  9082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9082
ggacuucguu ccugcuguac                                                   20


<210>  9083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9083
uuccucccca ccggaggagc                                                   20


<210>  9084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9084
ccaccggagg agcugcuccc                                                   20


<210>  9085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9085
gguggggagg aaggagccac                                                   20


<210>  9086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9086
uccggugggg aggaaggagc                                                   20


<210>  9087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9087
caggcgggac ccugggggug                                                   20


<210>  9088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9088
gaaaugccuu ccccucggga                                                   20


<210>  9089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9089
ggacccucac cgcgacugga                                                   20


<210>  9090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9090
ccgcgacugg acuucgcuca                                                   20


<210>  9091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9091
gcuucagacc cugggcugca                                                   20


<210>  9092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9092
uuaggcagcu gcagcccagg                                                   20


<210>  9093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9093
acuuuacaca cccagggccc                                                   20


<210>  9094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9094
cuccacuuua cacacccagg                                                   20


<210>  9095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9095
gagcccugag ccauccuggg                                                   20


<210>  9096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9096
gagguggcca cugccccucc                                                   20


<210>  9097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9097
gggcucagag guggccacug                                                   20


<210>  9098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9098
cugagaucaa ccuucccauu                                                   20


<210>  9099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9099
gagaucaacc uucccauuuu                                                   20


<210>  9100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9100
gagagccccu gccccaagua                                                   20


<210>  9101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9101
agaaaauggg aagguugauc                                                   20


<210>  9102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9102
uggucacauc cucaagaaaa                                                   20


<210>  9103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9103
ggggcaggaa guugcugggg                                                   20


<210>  9104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9104
aucuucuucc uuccccagca                                                   20


<210>  9105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9105
gcagaggauc uagcgggccu                                                   20


<210>  9106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9106
gcagaggugg ggguuggggg                                                   20


<210>  9107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9107
ggacaccagc ccuggaauag                                                   20


<210>  9108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9108
aagaccuacc cagagccacc                                                   20


<210>  9109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9109
ggguaggucu ucgagggggc                                                   20


<210>  9110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9110
cggauccccc cgggggggcc                                                   20


<210>  9111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9111
uugaggggga gcaggaggag                                                   20


<210>  9112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9112
aggaggcccc cccgggggga                                                   20


<210>  9113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9113
cccucaagga ggcccccccg                                                   20


<210>  9114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9114
ugcucccccu caaggaggcc                                                   20


<210>  9115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9115
uccugcuccc ccucaaggag                                                   20


<210>  9116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9116
gccuggcccc uccuccugcu                                                   20


<210>  9117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9117
ggcuguguga aagacacccu                                                   20


<210>  9118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9118
cuuuucaaaa ccaggguguc                                                   20


<210>  9119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9119
cccuuuucaa aaccagggug                                                   20


<210>  9120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9120
agccccucuc ccuuuucaaa                                                   20


<210>  9121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9121
cuagccccuc ucccuuuuca                                                   20


<210>  9122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9122
ggccccaccu cucuagcccc                                                   20


<210>  9123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9123
ggggucugga gaccacugcc                                                   20


<210>  9124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9124
agaccccaga guaagcuuga                                                   20


<210>  9125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9125
aagcaguggc cacaagaaga                                                   20


<210>  9126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9126
uggucuucuu guggccacug                                                   20


<210>  9127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9127
ucauggucuu cuuguggcca                                                   20


<210>  9128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9128
ggcggggucu ggggaaaggg                                                   20


<210>  9129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9129
acgaacccac uucugucugu                                                   20


<210>  9130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9130
cacccagccu ucugcagccu                                                   20


<210>  9131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9131
acucccaccc agccuucugc                                                   20


<210>  9132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9132
uccacuccca cccagccuuc                                                   20


<210>  9133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9133
ccuuucaucc ccuguagccc                                                   20


<210>  9134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9134
cuccccuuuc auccccugua                                                   20


<210>  9135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9135
gcagucugcu gcucccuccc                                                   20


<210>  9136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9136
gucucccucc uccuuggcug                                                   20


<210>  9137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9137
cuccuccuug gcuggcuuuu                                                   20


<210>  9138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9138
uccuuggcug gcuuuucugg                                                   20


<210>  9139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9139
uuggcuggcu uuucuggcag                                                   20


<210>  9140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9140
ggaccaugcc acugucugcc                                                   20


<210>  9141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9141
cuggggaggg aaagggcauc                                                   20


<210>  9142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9142
ccagggaggc agcucuggac                                                   20


<210>  9143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9143
ugaggcugug uccccagagu                                                   20


<210>  9144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9144
ggagugacuu ggggaugccc                                                   20


<210>  9145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9145
ggggacacag ccucaggagu                                                   20


<210>  9146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9146
cugucugaug cagccugccc                                                   20


<210>  9147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9147
ggcaggggca ggcugcauca                                                   20


<210>  9148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9148
ggcagcucag gcaggggcag                                                   20


<210>  9149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9149
uggcugggaa gcagccacgg                                                   20


<210>  9150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9150
uccuggcugg gaagcagcca                                                   20


<210>  9151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9151
agagucuuac ugccacccga                                                   20


<210>  9152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9152
ggagucagca gggccuguaa                                                   20


<210>  9153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9153
gguggcagua agacucugga                                                   20


<210>  9154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9154
acguacugcu cggguggcag                                                   20


<210>  9155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9155
ggggaggcug ucucgggcuc                                                   20


<210>  9156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9156
ccagagcccc caggugaagu                                                   20


<210>  9157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9157
ggcucccgug ccaggggugg                                                   20


<210>  9158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9158
cgugccaggg gugggugcag                                                   20


<210>  9159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9159
cugcacccac cccuggcacg                                                   20


<210>  9160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9160
ugccugccca gccucccugc                                                   20


<210>  9161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9161
ccugccugcc cagccucccu                                                   20


<210>  9162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9162
ggccucggcu cccacggguc                                                   20


<210>  9163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9163
gcucccacgg gucuggggcu                                                   20


<210>  9164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9164
cacgggucug gggcuguggu                                                   20


<210>  9165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9165
aguuaggguc cccaaccacc                                                   20


<210>  9166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9166
gaggaaggac cuggccugga                                                   20


<210>  9167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9167
gaggggugaa uggcucuagu                                                   20


<210>  9168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9168
aggccagguc cuuccucaga                                                   20


<210>  9169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9169
cuggggaugg cgcuccaggc                                                   20


<210>  9170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9170
cgccuggccu ucugcccccg                                                   20


<210>  9171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9171
agccguuccc caccugcaaa                                                   20


<210>  9172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9172
uggaacagcc ugagaggugu                                                   20


<210>  9173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9173
ggcuguucca cgaguuccuc                                                   20


<210>  9174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9174
caggcuguuc cacgaguucc                                                   20


<210>  9175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9175
ccggacaccu cucaggcugu                                                   20


<210>  9176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9176
aggccaccca ugcccuaccu                                                   20


<210>  9177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9177
gggcucaagg ccacccaugc                                                   20


<210>  9178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9178
gccucagggc ucaaggccac                                                   20


<210>  9179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9179
gcucagccuc agggcucaag                                                   20


<210>  9180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9180
aagacagcuc cgcucagccu                                                   20


<210>  9181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9181
caaagacagc uccgcucagc                                                   20


<210>  9182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9182
gcugaggcug cagcagaaag                                                   20


<210>  9183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9183
gcagaggugg cucucaaaga                                                   20


<210>  9184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9184
gagggaggaa ggagcugggc                                                   20


<210>  9185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9185
gagccagccu gucacagccu                                                   20


<210>  9186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9186
cucggagcca gccugucaca                                                   20


<210>  9187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9187
uuccucccuc ggagccagcc                                                   20


<210>  9188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9188
gcccccaacc augcaacugu                                                   20


<210>  9189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9189
ccgcccccaa ccaugcaacu                                                   20


<210>  9190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9190
ucuccgcccc caaccaugca                                                   20


<210>  9191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9191
uccucuccgc ccccaaccau                                                   20


<210>  9192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9192
accccugccu gucuugaccg                                                   20


<210>  9193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9193
gcggucaaga caggcagggg                                                   20


<210>  9194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9194
gcaccccugc agucugggcc                                                   20


<210>  9195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9195
cugcaccccu gcagucuggg                                                   20


<210>  9196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9196
gccgcagccu cucugcaccc                                                   20


<210>  9197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9197
uuucccggca ggccgggccc                                                   20


<210>  9198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9198
cugggccucu cugaacagug                                                   20


<210>  9199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9199
cugaacagug gagcguugug                                                   20


<210>  9200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9200
gaacagugga gcguugugag                                                   20


<210>  9201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9201
acuguucaga gaggcccagu                                                   20


<210>  9202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9202
caacgcucca cuguucagag                                                   20


<210>  9203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9203
gggccacgcu gagggugagg                                                   20


<210>  9204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9204
gcguggccca gagggggccu                                                   20


<210>  9205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9205
cccucagcgu ggcccagagg                                                   20


<210>  9206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9206
uguccucacc cucagcgugg                                                   20


<210>  9207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9207
ugcccgcugg cuccuguccu                                                   20


<210>  9208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9208
gggcccgggc aggggacagg                                                   20


<210>  9209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9209
gggguuccca ggcugaggag                                                   20


<210>  9210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9210
gccugggaac cccagagccu                                                   20


<210>  9211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9211
ucagccuggg aaccccagag                                                   20


<210>  9212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9212
cgguucccca acccgggguc                                                   20


<210>  9213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9213
guuccccaac ccggggucug                                                   20


<210>  9214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9214
uucuuccuuc uuuuugccuc                                                   20


<210>  9215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9215
cugucagcac cucuuccugu                                                   20


<210>  9216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9216
gucagcaccu cuuccuguug                                                   20


<210>  9217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9217
uccuguugcc ucccucuugc                                                   20


<210>  9218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9218
cucuugcucc ugggccugcc                                                   20


<210>  9219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9219
ugcuccuggg ccugccugca                                                   20


<210>  9220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9220
ugggccugcc ugcaucuccc                                                   20


<210>  9221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9221
cuuccccugu ccggccagag                                                   20


<210>  9222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9222
ggccggacag gggaagggag                                                   20


<210>  9223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9223
caggccgggg ucucuggccg                                                   20


<210>  9224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9224
cccaccccga ugccugcugc                                                   20


<210>  9225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9225
caccccgaug ccugcugcag                                                   20


<210>  9226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9226
gcuggggcug cagcaggcau                                                   20


<210>  9227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9227
aggcgacagg ccagccccuc                                                   20


<210>  9228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9228
caggccagca caggugggcu                                                   20


<210>  9229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9229
uggggccacu cacaggccag                                                   20


<210>  9230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9230
ugaggccaac cuaaaauuua                                                   20


<210>  9231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9231
ggagguuucc ugucuaggcu                                                   20


<210>  9232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9232
ggguuuauua uucuauuccc                                                   20


<210>  9233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9233
cuggguuuau uauucuauuc                                                   20


<210>  9234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9234
ugccuguaau cccagcacuu                                                   20


<210>  9235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9235
caaagugcug ggauuacagg                                                   20


<210>  9236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9236
acuaauccac ccgccuuggc                                                   20


<210>  9237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9237
ugaccucaac uaauccaccc                                                   20


<210>  9238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9238
acuaaaaaua caaaaauaag                                                   20


<210>  9239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9239
ggaggcugag acgugagaau                                                   20


<210>  9240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9240
cgaguagcug ggauuacaag                                                   20


<210>  9241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9241
gccucccgag uagcugggau                                                   20


<210>  9242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9242
cgucucagcc ucccgaguag                                                   20


<210>  9243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9243
caguuucaag caauucucac                                                   20


<210>  9244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9244
gccucccagu uucaagcaau                                                   20


<210>  9245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9245
aaccucugcc ucccaguuuc                                                   20


<210>  9246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9246
cuccaaccuc ugccucccag                                                   20


<210>  9247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9247
agccugggug acagagagac                                                   20


<210>  9248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9248
gucacccagg cuggagugca                                                   20


<210>  9249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9249
cugucaccca ggcuggagug                                                   20


<210>  9250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9250
aaaaaaaagg ggccgggcgc                                                   20


<210>  9251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9251
cacuuguaau cccagcacuu                                                   20


<210>  9252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9252
caaagugcug ggauuacaag                                                   20


<210>  9253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9253
gccucccaaa gugcugggau                                                   20


<210>  9254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9254
ggugaucugc cggccucggc                                                   20


<210>  9255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9255
ugaccucagg ugaucugccg                                                   20


<210>  9256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9256
acuaaaaaua caaauuagcu                                                   20


<210>  9257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9257
uauagcuggg auuacagguc                                                   20


<210>  9258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9258
gccuccuaua gcugggauua                                                   20


<210>  9259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9259
ugccucagcc uccuauagcu                                                   20


<210>  9260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9260
uugguucaag cacuucuccu                                                   20


<210>  9261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9261
gucuccuugg uucaagcacu                                                   20


<210>  9262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9262
uugcaaccuc ugucuccuug                                                   20


<210>  9263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9263
cuuuggugcc caggcuagaa                                                   20


<210>  9264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9264
gucucaaaaa aauauaugug                                                   20


<210>  9265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9265
aaaaaauaua ugugugugug                                                   20


<210>  9266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9266
agugcugaaa ugaguggaca                                                   20


<210>  9267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9267
uuucagcacu ugaggguuag                                                   20


<210>  9268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9268
guccacucau uucagcacuu                                                   20


<210>  9269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9269
gccuuggugg gucccagccu                                                   20


<210>  9270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9270
cuuacccagg aacccuguca                                                   20


<210>  9271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9271
guggugcaca gaggagccau                                                   20


<210>  9272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9272
gugcaccacu gaggguccuu                                                   20


<210>  9273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9273
ucugugcacc acugaggguc                                                   20


<210>  9274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9274
ugggucaggg caaaggacgc                                                   20


<210>  9275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9275
gcccaggcac uuuacggcgu                                                   20


<210>  9276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9276
ggcucagccc aggcacuuua                                                   20


<210>  9277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9277
ugcacacacc ucgggcucag                                                   20


<210>  9278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9278
cuuggaccgc acaaaaccau                                                   20


<210>  9279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9279
ucaccguggu acuuuucgua                                                   20


<210>  9280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9280
caggccacuu acugcuauac                                                   20


<210>  9281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9281
ggccacuuac ugcuauacgg                                                   20


<210>  9282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9282
ugaccucugc cguuggcucu                                                   20


<210>  9283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9283
gccguuggcu cuggguggga                                                   20


<210>  9284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9284
gggugggagc aguggggcug                                                   20


<210>  9285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9285
cacccagagc caacggcaga                                                   20


<210>  9286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9286
gacuggcgcc ccuacugcau                                                   20


<210>  9287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9287
ugcuggggug gcaugcagua                                                   20


<210>  9288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9288
gcaucuccac ucuguucccu                                                   20


<210>  9289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9289
acucuguucc cuuguuaucu                                                   20


<210>  9290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9290
guucccuugu uaucucgccc                                                   20


<210>  9291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9291
cccuggugcu gggauccggg                                                   20


<210>  9292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9292
gccauaggca cuuggcccag                                                   20


<210>  9293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9293
caagcacucu gccauaggca                                                   20


<210>  9294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9294
gaguccuguu gcuaauaagc                                                   20


<210>  9295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9295
gaggaccaaa ccagacagcu                                                   20


<210>  9296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9296
acgcuuauua gcaacaggac                                                   20


<210>  9297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9297
cccuccacgc uuauuagcaa                                                   20


<210>  9298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9298
guccuccccc uccacgcuua                                                   20


<210>  9299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9299
gggagugaag ugacuugccc                                                   20


<210>  9300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9300
cugagccuug cuccguccuc                                                   20


<210>  9301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9301
agcuuaaggg accaaggcug                                                   20


<210>  9302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9302
agucccagcc uuggucccuu                                                   20


<210>  9303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9303
ugggcaccau ucacgccugg                                                   20


<210>  9304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9304
ucccagggaa ggucugagau                                                   20


<210>  9305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9305
gaccuucccu gggaugagcu                                                   20


<210>  9306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9306
ccugggcaug uggccuggac                                                   20


<210>  9307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9307
gucucucaug ucagaaggug                                                   20


<210>  9308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9308
caugucagaa ggugggugcc                                                   20


<210>  9309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9309
ugucagaagg ugggugccuu                                                   20


<210>  9310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9310
uaccugcaac cccagggccu                                                   20


<210>  9311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9311
gucugacucu auguaauccc                                                   20


<210>  9312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9312
auguaauccc augcuuggcu                                                   20


<210>  9313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9313
uguggaagau ugcucccagg                                                   20


<210>  9314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9314
caggacgcug gcggaugugu                                                   20


<210>  9315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9315
cauccuugug acaucuguuc                                                   20


<210>  9316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9316
gacucacauc cuugugacau                                                   20


<210>  9317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9317
cuaacagauu gggagcccag                                                   20


<210>  9318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9318
caaucuguua gggaggcagc                                                   20


<210>  9319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9319
gucugggcuc ccaaucuguu                                                   20


<210>  9320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9320
ggcacagcac cuacaggcaa                                                   20


<210>  9321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9321
ccugugcccg auaccaugag                                                   20


<210>  9322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9322
ugguaucggg cacaggggag                                                   20


<210>  9323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9323
gccugaaguc ucaugguauc                                                   20


<210>  9324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9324
acucggccug aagucucaug                                                   20


<210>  9325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9325
ugcacagugu cacuccacuc                                                   20


<210>  9326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9326
cuugcacagu gucacuccac                                                   20


<210>  9327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9327
ccaugacucc agccgagccc                                                   20


<210>  9328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9328
agccgagccc acugaauagg                                                   20


<210>  9329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9329
gcuggaguca uggugaggcu                                                   20


<210>  9330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9330
guuuccugcu cucgguuucc                                                   20


<210>  9331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9331
cgguuuccuc agcugccugg                                                   20


<210>  9332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9332
guuuccucag cugccuggug                                                   20


<210>  9333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9333
gcugccuggu ggguuccacu                                                   20


<210>  9334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9334
cugggggucu ccuucugucc                                                   20


<210>  9335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9335
gggggucucc uucugucccg                                                   20


<210>  9336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9336
uucugucccg gcaccgccug                                                   20


<210>  9337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9337
uguuccucau ccgagucucu                                                   20


<210>  9338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9338
uccgagucuc ugcggaugcg                                                   20


<210>  9339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9339
gaugaggaac aggagcaggc                                                   20


<210>  9340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9340
gcggaugcgu ggaccccgcc                                                   20


<210>  9341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9341
gugcagccuc agcacuaagu                                                   20


<210>  9342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9342
gcacuaaguc cuggguccag                                                   20


<210>  9343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9343
gggacugccc caguuacucc                                                   20


<210>  9344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9344
uggggaaacu gaggacugga                                                   20


<210>  9345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9345
guuuccccag gaguaacugg                                                   20


<210>  9346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9346
aguccucagu uuccccagga                                                   20


<210>  9347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9347
gcuucuuugc ccgaguuuuc                                                   20


<210>  9348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9348
ggcaaagaag cagagcucca                                                   20


<210>  9349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9349
agggugagca ccagaccacu                                                   20


<210>  9350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9350
cccuagagaa aacucgggca                                                   20


<210>  9351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9351
uucuucaagg gaaccagcag                                                   20


<210>  9352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9352
augcugcugg uucccuugaa                                                   20


<210>  9353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9353
caggccacag cccccuuuug                                                   20


<210>  9354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9354
cccaggccac agcccccuuu                                                   20


<210>  9355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9355
ccaggggcuc uugggaucag                                                   20


<210>  9356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9356
ugggaucagu uuaaaacaga                                                   20


<210>  9357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9357
uaacuccuca agggugggcu                                                   20


<210>  9358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9358
ucaagggugg gcuggagccc                                                   20


<210>  9359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9359
agggugggcu ggagccccug                                                   20


<210>  9360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9360
agcccacccu ugaggaguua                                                   20


<210>  9361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9361
gcaggacagg aaggccuggg                                                   20


<210>  9362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9362
cuguacccca cauggcgugg                                                   20


<210>  9363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9363
uacccagagc ccugcccccu                                                   20


<210>  9364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9364
ggguaggagg ccaggggaca                                                   20


<210>  9365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9365
acagaggcca gggcccaccc                                                   20


<210>  9366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9366
guggaggggg cagggcucug                                                   20


<210>  9367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9367
gaaggaagcc caccaaccuu                                                   20


<210>  9368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9368
cagaaggaag cccaccaacc                                                   20


<210>  9369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9369
ucuccuucuu acccacccca                                                   20


<210>  9370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9370
ccuucuuacc caccccagag                                                   20


<210>  9371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9371
uucuuaccca ccccagagcc                                                   20


<210>  9372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9372
ggggugggua agaaggagag                                                   20


<210>  9373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9373
gcaggaaaug ccugguaggg                                                   20


<210>  9374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9374
gguuguguug uagggguggg                                                   20


<210>  9375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9375
gggugacacu agccacgcug                                                   20


<210>  9376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9376
cucagccucg agguccuaau                                                   20


<210>  9377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9377
gccucgaggu ccuaaucggg                                                   20


<210>  9378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9378
agguccuaau cgggagaaca                                                   20


<210>  9379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9379
aggcugagug agcugcaacg                                                   20


<210>  9380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9380
cgauuaggac cucgaggcug                                                   20


<210>  9381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9381
uuuuguucuc ccgauuagga                                                   20


<210>  9382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9382
aucgccaacu gcucguuuug                                                   20


<210>  9383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9383
gugcccgcuc caucgccaac                                                   20


<210>  9384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9384
gaacacagug gacauuuccu                                                   20


<210>  9385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9385
cugccccucc cuugguccag                                                   20


<210>  9386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9386
cuugguccag cagccuagcc                                                   20


<210>  9387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9387
uaucacaaga ggugacugug                                                   20


<210>  9388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9388
ugugauagga gggcuaggcu                                                   20


<210>  9389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9389
ugggaugcgu gggacgccug                                                   20


<210>  9390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9390
cgccaaccag acccuccugg                                                   20


<210>  9391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9391
gcuucugcuu ccucuagaug                                                   20


<210>  9392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9392
agaugaggaa ggugcccggc                                                   20


<210>  9393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9393
ucuagaggaa gcagaagcag                                                   20


<210>  9394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9394
gggcccaggg ggugugcuua                                                   20


<210>  9395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9395
gugacugcug cugcccuugc                                                   20


<210>  9396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9396
ucgauaggca agggcagcag                                                   20


<210>  9397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9397
cggccccagc auccucaucg                                                   20


<210>  9398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9398
agggugaccu cccggcccca                                                   20


<210>  9399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9399
gcacccacca agcgcagccu                                                   20


<210>  9400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9400
aggggcucug cacccaccaa                                                   20


<210>  9401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9401
ugcagccagg ggucccccga                                                   20


<210>  9402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9402
ggggaccccu ggcugcagga                                                   20


<210>  9403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9403
ugugcugaau uacaccaucu                                                   20


<210>  9404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9404
ugggcucaug ugcugaauua                                                   20


<210>  9405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9405
guggggccua gcucaugggc                                                   20


<210>  9406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9406
ccguggggcc uagcucaugg                                                   20


<210>  9407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9407
uccacacccc agcuggcugg                                                   20


<210>  9408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9408
ugcagcauga acagaccucg                                                   20


<210>  9409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9409
gcauguccgu cccccauguc                                                   20


<210>  9410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9410
ccccacagaa cuggugucag                                                   20


<210>  9411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9411
ccacagaacu ggugucaggg                                                   20


<210>  9412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9412
ccugacacca guucuguggg                                                   20


<210>  9413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9413
cugaggagug ggggcccugc                                                   20


<210>  9414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9414
gaggaguggg ggcccugccg                                                   20


<210>  9415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9415
gagaggcagc ccccacccgg                                                   20


<210>  9416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9416
ucagagaggc agcccccacc                                                   20


<210>  9417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9417
guccacggca gggcccccac                                                   20


<210>  9418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9418
cacacaggcu caguccacgg                                                   20


<210>  9419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9419
ccugggcugg accccaaucc                                                   20


<210>  9420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9420
ucuagaccac acuccccugg                                                   20


<210>  9421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9421
gccccgcccu ugccccuugg                                                   20


<210>  9422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9422
ucugccccgc ccuugccccu                                                   20


<210>  9423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9423
accuccucug ccccgcccuu                                                   20


<210>  9424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9424
ccaccuccuc ugccccgccc                                                   20


<210>  9425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9425
accuggaacg ccacccucuc                                                   20


<210>  9426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9426
gcaccuuggc agcagcagug                                                   20


<210>  9427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9427
cugcaccuug gcagcagcag                                                   20


<210>  9428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9428
gucugugcca agggccgcgg                                                   20


<210>  9429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9429
ccgcggcccu uggcacagac                                                   20


<210>  9430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9430
agaacaggcg ucuccccgcg                                                   20


<210>  9431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9431
gcguccggcc gugcuuuucc                                                   20


<210>  9432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9432
cuucccuuga cacuagagca                                                   20


<210>  9433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9433
agugucaagg gaagggagga                                                   20


<210>  9434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9434
agugaggaaa cugaggcuca                                                   20


<210>  9435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9435
cuugagcagu gggggugggg                                                   20


<210>  9436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9436
guuuccucac uugagcagug                                                   20


<210>  9437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9437
gagugggcca caggccagga                                                   20


<210>  9438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9438
gagccucagu uuccucacuu                                                   20


<210>  9439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9439
uggccugugg cccacucuga                                                   20


<210>  9440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9440
uccuggccug uggcccacuc                                                   20


<210>  9441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9441
auccccuccu ccuggccugu                                                   20


<210>  9442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9442
auucugccug ccaaggucac                                                   20


<210>  9443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9443
augcauguga ccuuggcagg                                                   20


<210>  9444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9444
cuggugggag ccacugggug                                                   20


<210>  9445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9445
ggugggagcc acuggguggg                                                   20


<210>  9446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9446
caccagagag ggccgcucua                                                   20


<210>  9447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9447
cgggacccug cggggcuggg                                                   20


<210>  9448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9448
ggacccugcg gggcuggggc                                                   20


<210>  9449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9449
ccgcagccag ccugggcacc                                                   20


<210>  9450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9450
uggccugaag gguuucacug                                                   20


<210>  9451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9451
ccuggccuga aggguuucac                                                   20


<210>  9452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9452
ccucuccugg ccugaagggu                                                   20


<210>  9453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9453
ccacccugcc ucgccucucc                                                   20


<210>  9454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9454
uccccacccu gccucgccuc                                                   20


<210>  9455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9455
cacccaaggc uggggcccac                                                   20


<210>  9456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9456
ggagaauuuu uucucaagug                                                   20


<210>  9457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9457
agaguccuga uguguggggu                                                   20


<210>  9458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9458
agugauuaaa agguagaaac                                                   20


<210>  9459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9459
ucaguguuug ugaagaacug                                                   20


<210>  9460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9460
ggauucacac uucaguucuu                                                   20


<210>  9461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9461
gcugcuugug guuugagacu                                                   20


<210>  9462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9462
aaccacaagc agcagaggcg                                                   20


<210>  9463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9463
agucucaaac cacaagcagc                                                   20


<210>  9464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9464
ccagucucaa accacaagca                                                   20


<210>  9465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9465
aggcgagcag cagugccagc                                                   20


<210>  9466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9466
ccuggagcca cucuccaguc                                                   20


<210>  9467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9467
ccuugccuca cuucacuguc                                                   20


<210>  9468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9468
cuucacuguc uccagcccca                                                   20


<210>  9469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9469
agccccaccu caccgucucc                                                   20


<210>  9470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9470
ccgucuccag ccccaccuca                                                   20


<210>  9471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9471
agccccaccu cacccucacc                                                   20


<210>  9472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9472
cccucaccac ccucggccug                                                   20


<210>  9473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9473
ccacccucgg ccuggaagcc                                                   20


<210>  9474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9474
gccuggaagc ccgcccuggc                                                   20


<210>  9475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9475
ucccuccagc caguguacgg                                                   20


<210>  9476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9476
cuccagccag uguacggccc                                                   20


<210>  9477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9477
agccagugua cggccccugc                                                   20


<210>  9478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9478
ggccuggcca ggcaggggcc                                                   20


<210>  9479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9479
gccuagggca acccucuucc                                                   20


<210>  9480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9480
uccaggugug gaggcccccg                                                   20


<210>  9481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9481
acaccuggaa gaggguugcc                                                   20


<210>  9482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9482
caugcccauc ucaagaaccu                                                   20


<210>  9483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9483
agaaccuuuc cuggggacag                                                   20


<210>  9484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9484
guccccagga aagguucuug                                                   20


<210>  9485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9485
ggccuggugu cucugucccc                                                   20


<210>  9486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9486
caggccuggu gucucugucc                                                   20


<210>  9487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9487
cucaggccug gugucucugu                                                   20


<210>  9488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9488
ggaugcccca cugggccuuc                                                   20


<210>  9489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9489
caucuccgga ugccccacug                                                   20


<210>  9490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9490
gaggacagag cuugagggcc                                                   20


<210>  9491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9491
gagggaagcu gcaauguucu                                                   20


<210>  9492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9492
guccucagag ggaagcugca                                                   20


<210>  9493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9493
agcucugucc ucagagggaa                                                   20


<210>  9494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9494
cugaagccca ggugccaugc                                                   20


<210>  9495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9495
gaagcccagg ugccaugcag                                                   20


<210>  9496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9496
gccuccaccc ugcaccgcuc                                                   20


<210>  9497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9497
acccugcacc gcucugugaa                                                   20


<210>  9498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9498
gugaagcccc uggggccucu                                                   20


<210>  9499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9499
gagccccgaa cacacugcgu                                                   20


<210>  9500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9500
gaggccccag gggcuucaca                                                   20


<210>  9501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9501
agugcaccag ccuuucucug                                                   20


<210>  9502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9502
guuuugcagc gagcagccuc                                                   20


<210>  9503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9503
cugcaaaaca gagaaaggcu                                                   20


<210>  9504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9504
cgugcgugcc cagggcuggc                                                   20


<210>  9505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9505
cugggcagag guccaggggu                                                   20


<210>  9506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9506
gcccagugag acaagccgcc                                                   20


<210>  9507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9507
gcugcggccg ugcugcacuc                                                   20


<210>  9508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9508
aguucuuuga aaaccucucu                                                   20


<210>  9509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9509
cucauugaga guccaauuag                                                   20


<210>  9510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9510
cauugagagu ccaauuagcg                                                   20


<210>  9511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9511
uugagagucc aauuagcgcu                                                   20


<210>  9512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9512
augagagagg uuuucaaaga                                                   20


<210>  9513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9513
caaugagaga gguuuucaaa                                                   20


<210>  9514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9514
gagcucugaa ggauguacug                                                   20


<210>  9515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9515
gagugaaaaa auugugacuu                                                   20


<210>  9516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9516
gaaggaugua cugguuacaa                                                   20


<210>  9517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9517
cuggggucug gccucaugua                                                   20


<210>  9518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9518
uguauggaca ugacagugaa                                                   20


<210>  9519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9519
ucuguuuguc ugucuguccu                                                   20


<210>  9520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9520
uggguccugc caugggccug                                                   20


<210>  9521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9521
aaggcccaga ugggcaccag                                                   20


<210>  9522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9522
ccacgggucc aagucccacu                                                   20


<210>  9523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9523
aagucaaugg cacaguucug                                                   20


<210>  9524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9524
gaaaucucca agucaauggc                                                   20


<210>  9525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9525
ucucugaaau cuccaaguca                                                   20


<210>  9526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9526
aaggaugagg gagcguuugg                                                   20


<210>  9527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9527
uccuuugagg auggaaccau                                                   20


<210>  9528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9528
cucauccuuu gaggauggaa                                                   20


<210>  9529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9529
acauggaaac caaacgcucc                                                   20


<210>  9530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9530
cugcugcgcc guggugaaug                                                   20


<210>  9531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9531
ggccacauuc accacggcgc                                                   20


<210>  9532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9532
cguucacccc uuuggccugc                                                   20


<210>  9533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9533
uggccucgcg uucaccccuu                                                   20


<210>  9534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9534
ccugccaugc cugacccaca                                                   20


<210>  9535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9535
ugcacacagg guccaccagc                                                   20


<210>  9536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9536
cacccuccug cacacagggu                                                   20


<210>  9537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9537
accucccacc cuccugcaca                                                   20


<210>  9538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9538
ccaccuccca cccuccugca                                                   20


<210>  9539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9539
ugaaggcugg gcucuccacc                                                   20


<210>  9540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9540
gcaggugccc acagccuccu                                                   20


<210>  9541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9541
gcagugcccg cccagguugg                                                   20


<210>  9542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9542
acaaggcugu gaccaaccug                                                   20


<210>  9543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9543
cccugacagg cacgcccaca                                                   20


<210>  9544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9544
cugacaggca cgcccacacu                                                   20


<210>  9545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9545
ugcugaaaag agaccuccua                                                   20


<210>  9546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9546
uuucagcacg agacaaacau                                                   20


<210>  9547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9547
uaauguucau gucuugauaa                                                   20


<210>  9548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9548
uggugucccu cuccacggga                                                   20


<210>  9549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9549
ccacgggaac ucaggguguc                                                   20


<210>  9550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9550
acgggaacuc agggugucca                                                   20


<210>  9551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9551
ggguguccag ggaacugcug                                                   20


<210>  9552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9552
cugucacugu gugcucaugu                                                   20


<210>  9553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9553
uguuugaugg ggagggcucu                                                   20


<210>  9554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9554
ccaucaaaca ugagcacaca                                                   20


<210>  9555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9555
gugcugggga cauccugcca                                                   20


<210>  9556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9556
aaggcugggg ucagcccugg                                                   20


<210>  9557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9557
uccaaggcug gggucagccc                                                   20


<210>  9558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9558
ggcaggcucc uccaaggcug                                                   20


<210>  9559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9559
cucaggcagg cuccuccaag                                                   20


<210>  9560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9560
gcacaguggc agccugggga                                                   20


<210>  9561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9561
guuucccccu cugcacagug                                                   20


<210>  9562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9562
aagagccuug gacccuuccg                                                   20


<210>  9563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9563
uugagacccu caguuucccc                                                   20


<210>  9564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9564
acugaccgga aggguccaag                                                   20


<210>  9565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9565
agcugccuuu ccuggugugg                                                   20


<210>  9566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9566
aaggcuguca gggcuucugu                                                   20


<210>  9567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9567
gagucacuga aggaguaagu                                                   20


<210>  9568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9568
gagcugcagc acuccaaggc                                                   20


<210>  9569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9569
uucagugacu ccgagcugca                                                   20


<210>  9570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9570
agacuuacuu acuccuucag                                                   20


<210>  9571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9571
uccagacuua cuuacuccuu                                                   20


<210>  9572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9572
ggcagcuccu ccagacuuac                                                   20


<210>  9573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9573
cuggacuggc gggggguggg                                                   20


<210>  9574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9574
cacucugccu ggugcccaca                                                   20


<210>  9575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9575
gccuggugcc cacagccugg                                                   20


<210>  9576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9576
gcuacucagc cuugagcguc                                                   20


<210>  9577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9577
gccuugagcg ucugugccgg                                                   20


<210>  9578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9578
aggcugagua gcugagccac                                                   20


<210>  9579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9579
gcuucugcag gaggaagaag                                                   20


<210>  9580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9580
ugcagaagcu gaguuacccg                                                   20


<210>  9581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9581
ccuucuuccu ccugcagaag                                                   20


<210>  9582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9582
uuuugcuccc cuucuuccuc                                                   20


<210>  9583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9583
gcaguguacu ggcuggccgg                                                   20


<210>  9584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9584
ccgcagugua cuggcuggcc                                                   20


<210>  9585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9585
gggacugggu gacgccaccg                                                   20


<210>  9586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9586
caagugccag cccccucggg                                                   20


<210>  9587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9587
ccucccaagu gccagccccc                                                   20


<210>  9588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9588
ccugaagcgg ccaccagggg                                                   20


<210>  9589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9589
ggccagggcc gcggggcccc                                                   20


<210>  9590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9590
ccagggcaga agggcacggu                                                   20


<210>  9591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9591
ucccacaggc ucaccagggc                                                   20


<210>  9592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9592
cgcucaggug gcuucggccg                                                   20


<210>  9593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9593
gguggcuucg gccgagggaa                                                   20


<210>  9594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9594
gccgaagcca ccugagcggg                                                   20


<210>  9595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9595
ccauagccag cgaccacgga                                                   20


<210>  9596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9596
guggucgcug gcuaugguga                                                   20


<210>  9597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9597
caccagccgc cgccguugug                                                   20


<210>  9598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9598
augucuccca ccagccgccg                                                   20


<210>  9599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9599
ucgaugucuc ccaccagccg                                                   20


<210>  9600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9600
ccugggcuga cgggcaccuc                                                   20


<210>  9601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9601
ccaaaggagu agagcagcag                                                   20


<210>  9602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9602
uuuggugagu ggcccugccc                                                   20


<210>  9603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9603
acuccuuugg ugaguggccc                                                   20


<210>  9604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9604
gcccgugcug ggccuggggc                                                   20


<210>  9605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9605
ucggcugggg acguucucug                                                   20


<210>  9606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9606
ucaucggcug gggacguucu                                                   20


<210>  9607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9607
ugcugcuggu gcccgccuuc                                                   20


<210>  9608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9608
gcacagcccg ugcccugcag                                                   20


<210>  9609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9609
ggggacugcc ugccacccgc                                                   20


<210>  9610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9610
aaagcgggug gcaggcaguc                                                   20


<210>  9611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9611
cuccaaagcg gguggcaggc                                                   20


<210>  9612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9612
ccauggccac cauccagggu                                                   20


<210>  9613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9613
ucggccucac cauggccacc                                                   20


<210>  9614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9614
cagccuacag caggggaaga                                                   20


<210>  9615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9615
cccuggcccu gcccugggug                                                   20


<210>  9616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9616
cgcccuggcc cugcccuggg                                                   20


<210>  9617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9617
cugaaauaac gccccugcuu                                                   20


<210>  9618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9618
cacaccagcg cuuccaguuc                                                   20


<210>  9619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9619
gcguguacuc caggcccgag                                                   20


<210>  9620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9620
aggcccgaga acaggaagag                                                   20


<210>  9621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9621
ggccuggagu acacgcugag                                                   20


<210>  9622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9622
uccuguucuc gggccuggag                                                   20


<210>  9623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9623
accucuuccu guucucgggc                                                   20


<210>  9624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9624
gcagccugcg ccgccugggc                                                   20


<210>  9625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9625
ccagggcuca gcagccugcg                                                   20


<210>  9626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9626
ccccagggcu cagcagccug                                                   20


<210>  9627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9627
gcacgcgcca ccucucccca                                                   20


<210>  9628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9628
ccugggcuuc cccgggcggc                                                   20


<210>  9629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9629
ccccugggcu uccccgggcg                                                   20


<210>  9630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9630
acgcuugggu uggucgaguc                                                   20


<210>  9631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9631
accaacccaa gcguggagcc                                                   20


<210>  9632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9632
agaggguggg uccuggccac                                                   20


<210>  9633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9633
ggagacagua aggacucgac                                                   20


<210>  9634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9634
uggccaggac ccacccucug                                                   20


<210>  9635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9635
gcugucgcuc guggccagga                                                   20


<210>  9636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9636
gcccccuggc ccugcugcgc                                                   20


<210>  9637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9637
aucgcccugg gguuccguga                                                   20


<210>  9638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9638
aaugccaucc ccacaggcgc                                                   20


<210>  9639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9639
ccaaugccau ccccacaggc                                                   20


<210>  9640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9640
ugcaggcucu ccaaugccau                                                   20


<210>  9641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9641
agggucccaa caccaagaga                                                   20


<210>  9642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9642
ugguguuggg acccuugagg                                                   20


<210>  9643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9643
cuugguguug ggacccuuga                                                   20


<210>  9644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9644
cuggcaucug gggcuggcac                                                   20


<210>  9645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9645
agccccuagg ccuguggguc                                                   20


<210>  9646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9646
aggggcagcg ucucuggcag                                                   20


<210>  9647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9647
ggcaggaagc agaagaugaa                                                   20


<210>  9648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9648
gaccugcugu ucaucuucug                                                   20


<210>  9649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9649
ucgcagccuc cgaccugcug                                                   20


<210>  9650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9650
cugccccugg aaauggcacc                                                   20


<210>  9651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9651
gagcauaggg cccaggguga                                                   20


<210>  9652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9652
gagccucccu gccccuggaa                                                   20


<210>  9653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9653
cugggcuuca cccugggccc                                                   20


<210>  9654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9654
gguggucuuu ucccuaggcg                                                   20


<210>  9655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9655
cugugcagcu cggguggucu                                                   20


<210>  9656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9656
ggcccgcagu caaggcaugg                                                   20


<210>  9657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9657
ccucuggccc gcagucaagg                                                   20


<210>  9658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9658
acggccaucg uugcugaccu                                                   20


<210>  9659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9659
ccacggccau cguugcugac                                                   20


<210>  9660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9660
aggcugauug ggggcaucag                                                   20


<210>  9661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9661
gagagguggc ccagacugca                                                   20


<210>  9662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9662
gagcuuugcg gccuuccugg                                                   20


<210>  9663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9663
cggagcuuug cggccuuccu                                                   20


<210>  9664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9664
uaugcagucu gggccaccuc                                                   20


<210>  9665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9665
uggccccugc cccugggcag                                                   20


<210>  9666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9666
uggccuuaag cgaccgcccc                                                   20


<210>  9667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9667
gaguagggcu uggcaaccca                                                   20


<210>  9668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9668
gagccacucc uggccuuaag                                                   20


<210>  9669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9669
acccugcccu auuucgaagc                                                   20


<210>  9670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9670
gaugcuucga aauagggcag                                                   20


<210>  9671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9671
gugccuuccu aggggccagg                                                   20


<210>  9672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9672
uggccccuag gaaggcacug                                                   20


<210>  9673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9673
uugaaagccu ggcucuggaa                                                   20


<210>  9674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9674
ggaacaggag ccacuggucc                                                   20


<210>  9675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9675
uguuccagag ccaggcuuuc                                                   20


<210>  9676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9676
ggggaccagu ggcuccuguu                                                   20


<210>  9677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9677
aggaugcgau gagggccaac                                                   20


<210>  9678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9678
ucgcauccug gaggggguuc                                                   20


<210>  9679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9679
uggccacugg uuggcccuca                                                   20


<210>  9680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9680
cucuccccac cuaaccccau                                                   20


<210>  9681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9681
ccccaccuaa ccccaugggg                                                   20


<210>  9682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9682
ccaccuaacc ccauggggcu                                                   20


<210>  9683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9683
cacccagcca guagccccau                                                   20


<210>  9684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9684
ucccacccag ccaguagccc                                                   20


<210>  9685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9685
ccaagcaguc agagguggcc                                                   20


<210>  9686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9686
gacugcuugg ggaggcgccc                                                   20


<210>  9687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9687
cuggggccac cucugacugc                                                   20


<210>  9688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9688
guccugcagu uucugugugc                                                   20


<210>  9689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9689
gcauucucug uccugcaguu                                                   20


<210>  9690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9690
uuggcucggc auucucuguc                                                   20


<210>  9691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9691
ggucucauug gcucggcauu                                                   20


<210>  9692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9692
caggucucau uggcucggca                                                   20


<210>  9693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9693
uggugccagg cagccccaug                                                   20


<210>  9694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9694
aggccaaugu ccagccccgu                                                   20


<210>  9695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9695
ggacggggcu ggacauuggc                                                   20


<210>  9696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9696
caggccaugg cccuugagcc                                                   20


<210>  9697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9697
agggccaugg ccugugagug                                                   20


<210>  9698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9698
gcucaagggc cauggccugu                                                   20


<210>  9699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9699
auuggggccc ccucggcuca                                                   20


<210>  9700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9700
ccauuggggc ccccucggcu                                                   20


<210>  9701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9701
ucucuccauu ggggcccccu                                                   20


<210>  9702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9702
gcgugucacg uucagauccu                                                   20


<210>  9703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9703
cugggcuggc augucuggug                                                   20


<210>  9704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9704
guccuugccu ucccacuccc                                                   20


<210>  9705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9705
ccaauucucg guccuugccu                                                   20


<210>  9706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9706
acgguccuau guuuggugga                                                   20


<210>  9707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9707
cuacgguccu auguuuggug                                                   20


<210>  9708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9708
gugcccuugg cgggcucucu                                                   20


<210>  9709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9709
gaacaggaca cuguuguacc                                                   20


<210>  9710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9710
ucuccacugg caucccgaug                                                   20


<210>  9711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9711
acuggcaucc cgauggcggu                                                   20


<210>  9712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9712
uggcagggcg ggguggacug                                                   20


<210>  9713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9713
auggcuccug gcagggcggg                                                   20


<210>  9714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9714
uccccuagga cccccucuau                                                   20


<210>  9715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9715
ccagcccuua ucgugauucc                                                   20


<210>  9716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9716
cgugggcacg gccguggcuc                                                   20


<210>  9717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9717
ccaacagccc gggcagcagg                                                   20


<210>  9718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9718
aacagcccgg gcagcagggg                                                   20


<210>  9719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9719
uggccuucac gcugcugcug                                                   20


<210>  9720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9720
ugcuggaccu ccuggccuuc                                                   20


<210>  9721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9721
gccuccugcu ggaccuccug                                                   20


<210>  9722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9722
ggcggcugcu gguggauggg                                                   20


<210>  9723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9723
acccccuccc caucccaugg                                                   20


<210>  9724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9724
ccaucccaug gugggcugcu                                                   20


<210>  9725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9725
gaccuggccu ggguggggug                                                   20


<210>  9726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9726
gcuuccccgc uaacccgacc                                                   20


<210>  9727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9727
ggggccuggc auacccccac                                                   20


<210>  9728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9728
ccggcugucg gguguggggg                                                   20


<210>  9729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9729
ggccuacgga cgcaggggcc                                                   20


<210>  9730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9730
ggaccguugc cuuugcggcu                                                   20


<210>  9731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9731
caggaccguu gccuuugcgg                                                   20


<210>  9732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9732
cccuggucuc ucaggaccgu                                                   20


<210>  9733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9733
cacgcccucg uaacagcgag                                                   20


<210>  9734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9734
uaacagcgag agaaaacuug                                                   20


<210>  9735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9735
cuguuacgag ggcgugggag                                                   20


<210>  9736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9736
cgcuguuacg agggcguggg                                                   20


<210>  9737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9737
gucucccugg cgggggccau                                                   20


<210>  9738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9738
cuggcggggg ccauggggug                                                   20


<210>  9739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9739
ugcguccggu gugcacccca                                                   20


<210>  9740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9740
cacuccgcca ucccgcgugc                                                   20


<210>  9741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9741
gccaucccgc gugcgucccg                                                   20


<210>  9742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9742
aacccccacg ccgcgcgccu                                                   20


<210>  9743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9743
caccgccccc accccgcgcg                                                   20


<210>  9744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9744
ccuacccugc gcaccucuca                                                   20


<210>  9745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9745
cacccgcccc acccccgcgu                                                   20


<210>  9746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9746
cccgccccac ccccgcguac                                                   20


<210>  9747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9747
ucccccaccc cgcgcguccc                                                   20


<210>  9748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9748
cccaccccgc gcguccccug                                                   20


<210>  9749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9749
gguugggggu gggacagggg                                                   20


<210>  9750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9750
ggacggacgg ucgcacagac                                                   20


<210>  9751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9751
gcacguucuc uuccggccgg                                                   20


<210>  9752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9752
uccggccgga gucaguggcg                                                   20


<210>  9753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9753
ggccggaaga gaacgugcag                                                   20


<210>  9754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9754
ccgguccugc gggucgcugc                                                   20


<210>  9755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9755
gggugcugcu aacccacagc                                                   20


<210>  9756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9756
gcucagggug cugcuaaccc                                                   20


<210>  9757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9757
uccgcuccgc ucagggugcu                                                   20


<210>  9758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9758
ggguuacgcg gcggcgggca                                                   20


<210>  9759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9759
gccucggggu uacgcggcgg                                                   20


<210>  9760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9760
uggccuggcc uccuugggcc                                                   20


<210>  9761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9761
uugggcccac gacgccugcc                                                   20


<210>  9762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9762
gcggggcagg cgucgugggc                                                   20


<210>  9763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9763
ggcccauggg uccgcuccgc                                                   20


<210>  9764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9764
ggcgagcgcu ggcgcagccu                                                   20


<210>  9765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9765
ccugaggccc cgcacacaaa                                                   20


<210>  9766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9766
ccguggaagg accgcgggcu                                                   20


<210>  9767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9767
ugccacacac acagcggugg                                                   20


<210>  9768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9768
ggcugcguga gcugaccccg                                                   20


<210>  9769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9769
cgcagcccga gcagaauggc                                                   20


<210>  9770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9770
cugugcaccu acuuuugcug                                                   20


<210>  9771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9771
gugcaccuac uuuugcugcg                                                   20


<210>  9772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9772
gcaccaaacg cagcaaaagu                                                   20


<210>  9773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9773
gccgccuguc cugggacuuc                                                   20


<210>  9774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9774
gcccacccaa uucacaccau                                                   20


<210>  9775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9775
cugggucacc cgaaggagga                                                   20


<210>  9776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9776
uucgggugac ccagggagcg                                                   20


<210>  9777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9777
uccuucgggu gacccaggga                                                   20


<210>  9778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9778
uuccgggcgc agaagcaccc                                                   20


<210>  9779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9779
agcguggguc gggugcuucu                                                   20


<210>  9780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9780
gggcaggaga agcuuugggc                                                   20


<210>  9781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9781
ugcccagagg gaccguuucc                                                   20


<210>  9782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9782
agccaggccc aaagcuucuc                                                   20


<210>  9783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9783
cggaaccacg ccaacgccug                                                   20


<210>  9784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9784
caccuccccu cccaccuucu                                                   20


<210>  9785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9785
ccucccaccu ucuaaaaugc                                                   20


<210>  9786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9786
caccuucuaa aaugcuugcg                                                   20


<210>  9787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9787
cguggccgac ccuaaccaga                                                   20


<210>  9788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9788
auagagaacu uccaauugug                                                   20


<210>  9789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9789
auggaguaaa ggcgguaugu                                                   20


<210>  9790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9790
uccuaauaga ugcaguuuuc                                                   20


<210>  9791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9791
gggaaaaaag cuaauaacag                                                   20


<210>  9792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9792
augaaacugc cauugcaaaa                                                   20


<210>  9793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9793
cugucggcaa auuuugcaau                                                   20


<210>  9794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9794
auuuugcuuc uaaccuccau                                                   20


<210>  9795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9795
augcccuccu uguuuacugc                                                   20


<210>  9796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9796
uuguuuacug cugcacgcag                                                   20


<210>  9797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9797
cacaguucaa ccugcgugca                                                   20


<210>  9798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9798
ucaaccguag uuucuaaucu                                                   20


<210>  9799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9799
cgcugcguga cucuucaacc                                                   20


<210>  9800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9800
ccaaacugcu ccuggcgaua                                                   20


<210>  9801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9801
uggcgauaac aucaccaucg                                                   20


<210>  9802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9802
ucugauguug uggcacccag                                                   20


<210>  9803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9803
gugcgaaaac agcuucgacu                                                   20


<210>  9804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9804
cugugauuuc aucucugacc                                                   20


<210>  9805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9805
gaccugacca auggguacuu                                                   20


<210>  9806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9806
cuggcugccc cccacccacc                                                   20


<210>  9807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9807
aaaccccaga ugcucaggga                                                   20


<210>  9808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9808
gggagaccga guaauaauaa                                                   20


<210>  9809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9809
cugagcaucu gggguuugga                                                   20


<210>  9810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9810
gucucccuga gcaucugggg                                                   20


<210>  9811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9811
agucucccac acagcuagcu                                                   20


<210>  9812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9812
cacacagcua gcucugcgug                                                   20


<210>  9813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9813
gcgugaauua ccuuuucucu                                                   20


<210>  9814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9814
guugcaaaug cccuuucuug                                                   20


<210>  9815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9815
ucaaugacau gacacgcagc                                                   20


<210>  9816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9816
agcugcgugu caugucauug                                                   20


<210>  9817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9817
uacacucuag cugcguguca                                                   20


<210>  9818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9818
auggacagcc aggugccugg                                                   20


<210>  9819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9819
uuuccucuuu gcuuggccaa                                                   20


<210>  9820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9820
uugcuuggcc aaagaggguu                                                   20


<210>  9821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9821
uuggccaagc aaagaggaaa                                                   20


<210>  9822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9822
ggacccuggc ccaacccucu                                                   20


<210>  9823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9823
gccacacggc uacugccacu                                                   20


<210>  9824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9824
ucuagauuug uggauccgug                                                   20


<210>  9825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9825
gagccaucug gggaggcugg                                                   20


<210>  9826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9826
gagacagguc uggcaggugc                                                   20


<210>  9827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9827
ccagauggcu cagagacagg                                                   20


<210>  9828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9828
ggcccugacg ggggaaaucu                                                   20


<210>  9829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9829
ucuccaagcu gcuggcuuca                                                   20


<210>  9830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9830
aagcugcugg cuucagccca                                                   20


<210>  9831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9831
gucuugcgcu uuccagagag                                                   20


<210>  9832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9832
ggaaagcgca agacagagac                                                   20


<210>  9833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9833
cuggaaagcg caagacagag                                                   20


<210>  9834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9834
cucuggaaag cgcaagacag                                                   20


<210>  9835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9835
uuuugagcuc caggccuacc                                                   20


<210>  9836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9836
aaaugaguca gucucucucu                                                   20


<210>  9837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9837
aggccuacca ggcagcccaa                                                   20


<210>  9838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9838
cacacugagg auggcucaug                                                   20


<210>  9839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9839
cacugaggau ggcucaugcu                                                   20


<210>  9840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9840
gugugagagg caguuacugc                                                   20


<210>  9841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9841
ugcucugguc cagccauggc                                                   20


<210>  9842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9842
gguccagcca uggcuugaac                                                   20


<210>  9843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9843
caacaagaac aaagccagac                                                   20


<210>  9844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9844
uucucccuag caucuucuuc                                                   20


<210>  9845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9845
cuagcaucuu cuuccuugcu                                                   20


<210>  9846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9846
aagaucccac accccguuag                                                   20


<210>  9847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9847
ccuccccagu cguagucugg                                                   20


<210>  9848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9848
ccagucguag ucugguuaau                                                   20


<210>  9849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9849
ccacggucac cguggcuaga                                                   20


<210>  9850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9850
gcgaugcuuc aggcacguac                                                   20


<210>  9851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9851
ugagguguga acuugacccc                                                   20


<210>  9852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9852
ugagaucaca gugaccagcc                                                   20


<210>  9853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9853
gucauccccu ggggaaugcc                                                   20


<210>  9854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9854
gccugcaaga ccgcauaccg                                                   20


<210>  9855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9855
cucagcaagg uggcaggucc                                                   20


<210>  9856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9856
gcaagguggc aggucccaac                                                   20


<210>  9857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9857
uggugcaagg cuuguuggga                                                   20


<210>  9858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9858
cuggccagcu ugugaaguuc                                                   20


<210>  9859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9859
uuacuucuua cagcucacag                                                   20


<210>  9860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9860
cagucccucc cggguccagc                                                   20


<210>  9861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9861
cggguccagc acaccugagg                                                   20


<210>  9862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9862
ggugugcugg acccgggagg                                                   20


<210>  9863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9863
cucuugauua gugcagggga                                                   20


<210>  9864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9864
ugauuagugc aggggaaaag                                                   20


<210>  9865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9865
ucccaccucc gagagugcag                                                   20


<210>  9866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9866
caccuccgag agugcagugu                                                   20


<210>  9867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9867
gagagugcag uguccugaau                                                   20


<210>  9868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9868
gaggugggag gagacugggu                                                   20


<210>  9869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9869
cggagguggg aggagacugg                                                   20


<210>  9870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9870
auucaggaca cugcacucuc                                                   20


<210>  9871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9871
gcuggaacag ccacaguugg                                                   20


<210>  9872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9872
gauuucuaaa auaucugcaa                                                   20


<210>  9873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9873
uggggacugg ggauucuggc                                                   20


<210>  9874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9874
gggaucggga auggucugug                                                   20


<210>  9875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9875
ccccacccgc ugccugcggu                                                   20


<210>  9876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9876
agcucccccc acccgcugcc                                                   20


<210>  9877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9877
aaaaaaaauu acuuuuuugg                                                   20


<210>  9878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9878
caccuauaau uggggggcca                                                   20


<210>  9879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9879
gguaauccac cugccuuggc                                                   20


<210>  9880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9880
ugcuuccuua acaguggcuu                                                   20


<210>  9881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9881
cagccagagc cugcuuggga                                                   20


<210>  9882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9882
gccagagccu gcuugggagu                                                   20


<210>  9883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9883
ggcugagagg uggggacaga                                                   20


<210>  9884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9884
caagcaggcu cuggcugaga                                                   20


<210>  9885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9885
guagucaucu gcucaacugc                                                   20


<210>  9886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9886
acugcagaac uggcagacgc                                                   20


<210>  9887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9887
cacugagccc acagcccugg                                                   20


<210>  9888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9888
gugggagcug acggggggcg                                                   20


<210>  9889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9889
cagggagaug cugccagcac                                                   20


<210>  9890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9890
cugggaggcc agggcugugg                                                   20


<210>  9891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9891
ucucacaggu cagcggccgg                                                   20


<210>  9892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9892
caggucagcg gccggcagag                                                   20


<210>  9893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9893
gccggccgcu gaccugugag                                                   20


<210>  9894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9894
gacacagcuc cugaaaaaca                                                   20


<210>  9895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9895
ugaaaaacac gaaauccccg                                                   20


<210>  9896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9896
gcgaugacuc accugcugcg                                                   20


<210>  9897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9897
ccugcugcgu gcccugagcu                                                   20


<210>  9898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9898
gggcacgcag caggugaguc                                                   20


<210>  9899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9899
acgcacgggu ucuguggugu                                                   20


<210>  9900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9900
cgcugccuug acaccacaga                                                   20


<210>  9901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9901
cagcacuguc cucacgcugc                                                   20


<210>  9902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9902
cugcagcagg auggugcccu                                                   20


<210>  9903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9903
aguccuggca cagccggaac                                                   20


<210>  9904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9904
ucaagaagac aguggcuuua                                                   20


<210>  9905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9905
cucuucaaga agacaguggc                                                   20


<210>  9906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9906
ggggccagcc cacggcccuc                                                   20


<210>  9907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9907
caggggccag cccacggccc                                                   20


<210>  9908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9908
cugaaaggag gggacuuggg                                                   20


<210>  9909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9909
gaaaggaggg gacuugggga                                                   20


<210>  9910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9910
uuucagagag ugcucucagg                                                   20


<210>  9911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9911
ccaagucccc uccuuucaga                                                   20


<210>  9912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9912
aacuccccaa guccccuccu                                                   20


<210>  9913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9913
ucacagccag aaacgucaac                                                   20


<210>  9914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9914
cagccagaaa cgucaacaga                                                   20


<210>  9915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9915
uucccagaca aacuuggcac                                                   20


<210>  9916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9916
cggccuuucg ugccaaguuu                                                   20


<210>  9917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9917
gccugggcuc agacaugucc                                                   20


<210>  9918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9918
ccuggagcuc cugcgggugg                                                   20


<210>  9919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9919
aggugaggcu ucccggccac                                                   20


<210>  9920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9920
ugcggguggc ugcaguccgc                                                   20


<210>  9921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9921
cggaucaccu ggcggacugc                                                   20


<210>  9922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9922
ucacggauca ccuggcggac                                                   20


<210>  9923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9923
aagcccuccu cacggaucac                                                   20


<210>  9924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9924
ccaagcccuc cucacggauc                                                   20


<210>  9925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9925
uguacggguc ccugccaucc                                                   20


<210>  9926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9926
cagacugucc ugccuggcug                                                   20


<210>  9927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9927
ugcccucaca gacuguccug                                                   20


<210>  9928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9928
ugccuccugc ccucacagac                                                   20


<210>  9929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9929
ucuugccucc ugcccucaca                                                   20


<210>  9930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9930
cauaccggau gugauuggcc                                                   20


<210>  9931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9931
gucgaaguug gggcccucag                                                   20


<210>  9932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9932
gucuacucgc ccagcggagg                                                   20


<210>  9933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9933
cccagcggag ggagaggcug                                                   20


<210>  9934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9934
gcugggcgag uagacugagg                                                   20


<210>  9935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9935
cuccgcuggg cgaguagacu                                                   20


<210>  9936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9936
cccuccgcug ggcgaguaga                                                   20


<210>  9937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9937
gcugccacgu ggccacaucc                                                   20


<210>  9938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9938
cuagcagaca ccacgagcag                                                   20


<210>  9939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9939
agcagacacc acgagcaguu                                                   20


<210>  9940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9940
uggugucugc uagagaggau                                                   20


<210>  9941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9941
gaacugcucg uggugucugc                                                   20


<210>  9942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9942
gaaagggugc accagagugg                                                   20


<210>  9943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9943
ggugcacccu uucagagcgc                                                   20


<210>  9944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9944
guccugucgc acuuggaauu                                                   20


<210>  9945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9945
cucaaaucaa cucaccuugg                                                   20


<210>  9946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9946
aaucaacuca ccuuggcuug                                                   20


<210>  9947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9947
ccuuggcuug cuuuguuugg                                                   20


<210>  9948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9948
aaacaaagca agccaaggug                                                   20


<210>  9949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9949
gguauaaacc ucugggacaa                                                   20


<210>  9950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9950
gggacaaagc cacauacucc                                                   20


<210>  9951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9951
aggaacaggc agcacacgaa                                                   20


<210>  9952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9952
aggacguggu gaagggccug                                                   20


<210>  9953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9953
acaugcggca ggggucggcc                                                   20


<210>  9954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9954
ccacaugcgg caggggucgg                                                   20


<210>  9955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9955
ccaaggugcg uucucuccac                                                   20


<210>  9956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9956
gucagcugcu caccaaggug                                                   20


<210>  9957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9957
ugugccucag ucagcugcuc                                                   20


<210>  9958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9958
uuuauuugaa aaucacuggg                                                   20


<210>  9959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9959
gcuuaccaca uccaacccug                                                   20


<210>  9960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9960
aucauuucuu ccaucucaug                                                   20


<210>  9961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9961
ugcaucgcau cucggagaac                                                   20


<210>  9962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9962
gagaacaaau uugauagcgu                                                   20


<210>  9963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9963
gagaugcgau gcaugagaug                                                   20


<210>  9964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9964
ugacuuuaca uuucugcuua                                                   20


<210>  9965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9965
ccugacuuua cauuucugcu                                                   20


<210>  9966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9966
cagucauuga uaaguugguu                                                   20


<210>  9967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9967
gugcucagca ccaagaacaa                                                   20


<210>  9968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9968
cagcgcucca cacacacuca                                                   20


<210>  9969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9969
acacacacuc aauccacgua                                                   20


<210>  9970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9970
auccacguac uucuaauuuu                                                   20


<210>  9971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9971
cagaaggaaa caaagcaaaa                                                   20


<210>  9972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9972
ggugguugca cuucugaauu                                                   20


<210>  9973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9973
ccaccaccaa aagcugcucu                                                   20


<210>  9974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9974
accaccaaaa gcugcucuuc                                                   20


<210>  9975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9975
uccaucgauc uuccuaacaa                                                   20


<210>  9976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9976
guuguuagga agaucgaugg                                                   20


<210>  9977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9977
guuccucaua ggauucaggg                                                   20


<210>  9978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9978
uaggauucag gggcuaucaa                                                   20


<210>  9979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9979
aaaauaaaua uauauacaua                                                   20


<210>  9980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9980
aucucaaaaa uaaauauaua                                                   20


<210>  9981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9981
cucuguugcc caggcuggag                                                   20


<210>  9982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9982
guugcccagg cuggagugca                                                   20


<210>  9983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9983
agccugggca acagagcgag                                                   20


<210>  9984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9984
gcucacugaa acuuccgccu                                                   20


<210>  9985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9985
cugaaacuuc cgccuccugg                                                   20


<210>  9986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9986
uggguucaag agauucuccu                                                   20


<210>  9987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9987
ugaacccagg aggcggaagu                                                   20


<210>  9988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9988
ugccccagcc ugcugaguag                                                   20


<210>  9989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9989
gguucuggga uaaccuuuau                                                   20


<210>  9990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9990
ucucugguag cuuuuccagc                                                   20


<210>  9991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9991
gguagcuuuu ccagcucuuu                                                   20


<210>  9992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9992
uuccuugccg cuuaucaacc                                                   20


<210>  9993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9993
gcucuuuugc uggcuucucg                                                   20


<210>  9994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9994
uuugcuggcu ucucguuuuc                                                   20


<210>  9995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9995
uuuucuuccu cacucuccac                                                   20


<210>  9996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9996
cucuccacgu uggauuccag                                                   20


<210>  9997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9997
ccacguugga uuccaggucc                                                   20


<210>  9998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9998
acguuggauu ccagguccaa                                                   20


<210>  9999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  9999
ccucuguguc cuccccgccu                                                   20


<210>  10000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10000
ucuguguccu ccccgccuga                                                   20


<210>  10001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10001
guguccuccc cgccugaacu                                                   20


<210>  10002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10002
ccgccugaac ugucaccuuc                                                   20


<210>  10003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10003
uugcucucag ggucacuggc                                                   20


<210>  10004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10004
cagggucacu ggcuuccuug                                                   20


<210>  10005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10005
gggucacugg cuuccuugcu                                                   20


<210>  10006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10006
uccuggacau cuuccucgac                                                   20


<210>  10007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10007
acauucaucu uuccauccua                                                   20


<210>  10008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10008
ugguaggaug gaaagaugaa                                                   20


<210>  10009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10009
ugcccugugg uuuccacgcu                                                   20


<210>  10010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10010
uuuuuuaauu uaaaaacauu                                                   20


<210>  10011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10011
cuuuuuuuaa uuuaaaaaca                                                   20


<210>  10012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10012
cucuuuuuuu aauuuaaaaa                                                   20


<210>  10013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10013
uucucucucu uuuuuuaauu                                                   20


<210>  10014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10014
uccuuuccaa gcauucuucg                                                   20


<210>  10015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10015
cagccugagc aggaaggaau                                                   20


<210>  10016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10016
gccugagcag gaaggaauga                                                   20


<210>  10017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10017
ggcugagaga cuucgaagaa                                                   20


<210>  10018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10018
uuccuuccug cucaggcuga                                                   20


<210>  10019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10019
aagacaucuc auuccuuccu                                                   20


<210>  10020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10020
uccaacauau ggugaggggg                                                   20


<210>  10021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10021
ugaggugcug ccacccuacc                                                   20


<210>  10022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10022
ggagcagggc ugugcugcug                                                   20


<210>  10023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10023
agcuuccuga ggugcuccug                                                   20


<210>  10024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10024
ggaagcugga gguagggugg                                                   20


<210>  10025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10025
ugcucuuccu uugccaauuc                                                   20


<210>  10026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10026
uccuuugcca auucugccuc                                                   20


<210>  10027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10027
gucuucaucc uguuagaggg                                                   20


<210>  10028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10028
aacaggauga agacggaggc                                                   20


<210>  10029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10029
cgaaccauca ugucauaugc                                                   20


<210>  10030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10030
gugagugaag aguuuguuuc                                                   20


<210>  10031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10031
cugagcuugg gugaccgacu                                                   20


<210>  10032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10032
ucacucacug agcuugggug                                                   20


<210>  10033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10033
caccuugggu uuuuccuuuu                                                   20


<210>  10034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10034
guucucugac uugggaguuu                                                   20


<210>  10035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10035
gacuugggag uuuuguggga                                                   20


<210>  10036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10036
caagucagag aacagagaca                                                   20


<210>  10037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10037
ugucccacaa aacucccaag                                                   20


<210>  10038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10038
ccugucccac aaaacuccca                                                   20


<210>  10039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10039
gugagcucga gggcaucuuc                                                   20


<210>  10040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10040
cggagaagcu agaccaagac                                                   20


<210>  10041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10041
agggcaucuu cucguugagc                                                   20


<210>  10042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10042
agcucacgga gaagcuagac                                                   20


<210>  10043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10043
uugagcuugu cucucccucu                                                   20


<210>  10044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10044
acgagaagau gcccucgagc                                                   20


<210>  10045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10045
cccucugggg aaaaaauaac                                                   20


<210>  10046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10046
cucuggggaa aaaauaacag                                                   20


<210>  10047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10047
ggggaaaaaa uaacagacac                                                   20


<210>  10048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10048
caauaaaugc uuuuacugaa                                                   20


<210>  10049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10049
uauaaaauau uaaacacagc                                                   20


<210>  10050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10050
acgguaagac aggcucacca                                                   20


<210>  10051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10051
cuaacccacc uucucuuguu                                                   20


<210>  10052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10052
uguuuugacu uggcaaugag                                                   20


<210>  10053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10053
uugccaaguc aaaacaagag                                                   20


<210>  10054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10054
ucaaucagcu cuuuccggga                                                   20


<210>  10055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10055
uuccgggacu ucgguuucuc                                                   20


<210>  10056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10056
cgcuccucgc cuuccuguug                                                   20


<210>  10057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10057
ucgccuuccu guugagucuu                                                   20


<210>  10058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10058
ccuuccuguu gagucuucuu                                                   20


<210>  10059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10059
acaggaaggc gaggagcggg                                                   20


<210>  10060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10060
uucacaagaa gacucaacag                                                   20


<210>  10061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10061
uccaaagugg gcagcaguca                                                   20


<210>  10062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10062
aaagugggca gcagucagcu                                                   20


<210>  10063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10063
gcugggggca aaaggcagaa                                                   20


<210>  10064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10064
aggcccugcc cagggaggug                                                   20


<210>  10065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10065
agucaccugu accacggcgc                                                   20


<210>  10066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10066
agucaccugc acgccacggc                                                   20


<210>  10067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10067
agucaccucc acgccacggc                                                   20


<210>  10068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10068
aagcuuuguc uugucagugu                                                   20


<210>  10069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10069
caaagcuuug ucuugucagu                                                   20


<210>  10070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10070
gacucuggca ucgggcaaaa                                                   20


<210>  10071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10071
ggcaucgggc aaaacaccuu                                                   20


<210>  10072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10072
gagcucaugg guagaacgag                                                   20


<210>  10073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10073
gagaaauaag guguuuugcc                                                   20


<210>  10074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10074
uggguagaac gagcuauuuu                                                   20


<210>  10075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10075
uucuacccau gagcucagag                                                   20


<210>  10076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10076
aaauagcucg uucuacccau                                                   20


<210>  10077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10077
acgcccacag gcccgugcac                                                   20


<210>  10078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10078
ccagacaacg uuccucgauc                                                   20


<210>  10079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10079
auccucagca ucgcugucac                                                   20


<210>  10080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10080
gcaucgcugu cacuguccac                                                   20


<210>  10081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10081
augucugcca aagacuggcc                                                   20


<210>  10082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10082
uuauggccag ucuuuggcag                                                   20


<210>  10083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10083
ugaugucgcu gacagaagag                                                   20


<210>  10084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10084
ucugucagcg acaucaugag                                                   20


<210>  10085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10085
uccaguuucu uuccauaccu                                                   20


<210>  10086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10086
aguuucuuuc cauaccugcu                                                   20


<210>  10087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10087
ggaacagcag guauggaaag                                                   20


<210>  10088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10088
ucaucaucuu cuccucgggg                                                   20


<210>  10089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10089
ucggggcuca uguugcuguu                                                   20


<210>  10090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10090
gggcucaugu ugcuguugua                                                   20


<210>  10091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10091
uguugcuguu guauucuccg                                                   20


<210>  10092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10092
gaagcguuua ucucugaaua                                                   20


<210>  10093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10093
gaauacauug gauuuauccc                                                   20


<210>  10094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10094
uuuaguaaag ucuguguacg                                                   20


<210>  10095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10095
caaaaaauuc uugugauuuc                                                   20


<210>  10096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10096
aggacagcca acuuugaaua                                                   20


<210>  10097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10097
cagcuuucuu uagggaauuc                                                   20


<210>  10098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10098
cacagcuuuc uuuagggaau                                                   20


<210>  10099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10099
guccucucac agcuuucuuu                                                   20


<210>  10100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10100
cccaucucug uccucucaca                                                   20


<210>  10101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10101
gcggauaaag aauggugaag                                                   20


<210>  10102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10102
cuauuuaaau cacaaggucu                                                   20


<210>  10103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10103
caucugauug ccagcuagac                                                   20


<210>  10104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10104
augaacucug uacggacaga                                                   20


<210>  10105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10105
guacggacag aggcugcuug                                                   20


<210>  10106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10106
cucccucugc agggacagac                                                   20


<210>  10107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10107
gccucuaaaa auauuaguuc                                                   20


<210>  10108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10108
aaaaauauua guucucauua                                                   20


<210>  10109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10109
uuaucuggaa uaugauucua                                                   20


<210>  10110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10110
uauuacguau uuauagccua                                                   20


<210>  10111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10111
uucuuucuua aacuauauag                                                   20


<210>  10112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10112
ccgugcgccc cccgcuuacc                                                   20


<210>  10113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10113
ggaagguaag cggggggcgc                                                   20


<210>  10114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10114
cgcacgggcc cucaggaagg                                                   20


<210>  10115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10115
aacggauugg aguuggccuu                                                   20


<210>  10116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10116
aauccguucg aggugaaagu                                                   20


<210>  10117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10117
cgcucccgcc ggcgccccgg                                                   20


<210>  10118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10118
cgccggcgcc ccggaggccu                                                   20


<210>  10119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10119
ggggcgccgg cgggagcgcg                                                   20


<210>  10120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10120
ggcccuuggg cgcagcgggg                                                   20


<210>  10121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10121
ucucgcgaga acagcgcagc                                                   20


<210>  10122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10122
cgagaacagc gcagcaccuc                                                   20


<210>  10123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10123
cgagacgagg aagcgguucc                                                   20


<210>  10124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10124
gacucgcgag aaguaaacac                                                   20


<210>  10125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10125
cgagaaguaa acaccgcgcc                                                   20


<210>  10126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10126
cgagucggag gugcugcgcu                                                   20


<210>  10127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10127
ccgauaggcu cagcgacuac                                                   20


<210>  10128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10128
gcgacuacaa cucccagcag                                                   20


<210>  10129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10129
cagcaggcca cgcgccgcgg                                                   20


<210>  10130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10130
uggcgcaggg ccuucuggga                                                   20


<210>  10131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10131
cagaaggccc ugcgccaaga                                                   20


<210>  10132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10132
ccgccgcggc cggggcacua                                                   20


<210>  10133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10133
cucuucagcu aagccguuag                                                   20


<210>  10134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10134
ucagcuaagc cguuagcgcc                                                   20


<210>  10135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10135
gcgcuaacgg cuuagcugaa                                                   20


<210>  10136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10136
cgggcgggcu cggcgcuaac                                                   20


<210>  10137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10137
gucuccucgg ucucgcagaa                                                   20


<210>  10138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10138
ucggucucgc agaauccgcc                                                   20


<210>  10139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10139
gucucgcaga auccgccggc                                                   20


<210>  10140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10140
cagaauccgc cggcggcggc                                                   20


<210>  10141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10141
auguccuggc gccgccgccg                                                   20


<210>  10142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10142
agaacaucgu ggccaacucg                                                   20


<210>  10143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10143
agcuccaugu ccuggcgccg                                                   20


<210>  10144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10144
cugcugcuga aagcgcguca                                                   20


<210>  10145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10145
gggggggggg ucgggggcgc                                                   20


<210>  10146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10146
gucucggacc ucaugucucc                                                   20


<210>  10147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10147
gaccucaugu cucccuugcc                                                   20


<210>  10148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10148
ugucucccuu gccugcgucu                                                   20


<210>  10149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10149
cuugccugcg ucucaagaga                                                   20


<210>  10150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10150
agagagcugg cgacagagcc                                                   20


<210>  10151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10151
ugagacgcag gcaagggaga                                                   20


<210>  10152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10152
cuugagacgc aggcaaggga                                                   20


<210>  10153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10153
gucgccagcu cucuugagac                                                   20


<210>  10154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10154
gaccucaagu cccugugcua                                                   20


<210>  10155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10155
agucccugug cuagccacgg                                                   20


<210>  10156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10156
aaccauuaau caagcuauac                                                   20


<210>  10157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10157
gcauguaucc auguauaucu                                                   20


<210>  10158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10158
acaaaaacca caaaauuauc                                                   20


<210>  10159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10159
cuauguugcc caggcuaguc                                                   20


<210>  10160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10160
agugauccua cccucccacu                                                   20


<210>  10161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10161
cacuucagcc ucccaaagug                                                   20


<210>  10162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10162
caaagugcug ggauuacagg                                                   20


<210>  10163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10163
gccaacaaaa gguuacccca                                                   20


<210>  10164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10164
caccuguaau cccagcacuu                                                   20


<210>  10165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10165
agaacauucu uuuggccagg                                                   20


<210>  10166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10166
ucaaaaaacu cuagaauuag                                                   20


<210>  10167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10167
aaaaacucua gaauuagggc                                                   20


<210>  10168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10168
agaauuaggg cuuucuuaag                                                   20


<210>  10169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10169
aguaaauaug ugguuaauug                                                   20


<210>  10170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10170
uauuacauuu uugugcuuug                                                   20


<210>  10171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10171
aacaaaauaa ucuguaggau                                                   20


<210>  10172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10172
auaaauaccc uaucuccaaa                                                   20


<210>  10173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10173
aaauaagauc acugucugag                                                   20


<210>  10174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10174
gacagugauc uuauuuggag                                                   20


<210>  10175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10175
aaagcccaug aucuuaacug                                                   20


<210>  10176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10176
gugcccucuu uauacuaucu                                                   20


<210>  10177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10177
uuauacuauc ucaacgacgg                                                   20


<210>  10178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10178
acgacggugu caguuacuuc                                                   20


<210>  10179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10179
aaaacgguuu auugugugcc                                                   20


<210>  10180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10180
agggauacag ggaugaauaa                                                   20


<210>  10181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10181
uucugagaag cugacaguca                                                   20


<210>  10182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10182
gaaggagaua uucaucuguu                                                   20


<210>  10183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10183
gugucugcuu gcuucagccc                                                   20


<210>  10184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10184
ucuguuuagc ucauugaaac                                                   20


<210>  10185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10185
guuuagcuca uugaaacacu                                                   20


<210>  10186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10186
uugaaacacu cauuguuuuc                                                   20


<210>  10187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10187
uuguuuucuu ucucuuucuc                                                   20


<210>  10188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10188
uucucucuuu cuuucucucu                                                   20


<210>  10189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10189
cuuucuuucu cucucuuucc                                                   20


<210>  10190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10190
uucuuucucu cucuuucccu                                                   20


<210>  10191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10191
auuuuagcug uaaaaaagaa                                                   20


<210>  10192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10192
auauggaucu uuaggauaga                                                   20


<210>  10193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10193
ccauggcugu gcaucccaaa                                                   20


<210>  10194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10194
uccuuucccc uuuucgggug                                                   20


<210>  10195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10195
cugucugcca aauaaaagcu                                                   20


<210>  10196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10196
cccugucugc caaauaaaag                                                   20


<210>  10197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10197
gcagcuggga ccacaagcau                                                   20


<210>  10198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10198
ucagcagcug ggaccacaag                                                   20


<210>  10199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10199
gccuccucag cagcugggac                                                   20


<210>  10200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10200
ugaguccagg aagucaaggc                                                   20


<210>  10201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10201
agagauccag cuaccucagc                                                   20


<210>  10202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10202
cugcagccuu gacuuccugg                                                   20


<210>  10203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10203
gucacccagg cuagaaugca                                                   20


<210>  10204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10204
aaaaagaaaa aaaauggucc                                                   20


<210>  10205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10205
acaacaagcc uacuagaugc                                                   20


<210>  10206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10206
gcaucuagua ggcuuguugu                                                   20


<210>  10207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10207
augugcaaau accccagaac                                                   20


<210>  10208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10208
ucuaggugcu guucuggggu                                                   20


<210>  10209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10209
uuccacccac uuggccuggc                                                   20


<210>  10210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10210
gcaccuggcu ugcccuuggc                                                   20


<210>  10211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10211
ugcaacccuu gcugcucugc                                                   20


<210>  10212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10212
uuugcucaug caacccuugc                                                   20


<210>  10213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10213
uucuuccugg acaugggaca                                                   20


<210>  10214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10214
aguugucugu guaccucauu                                                   20


<210>  10215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10215
ucuugcuuac ccuccaguug                                                   20


<210>  10216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10216
auaaagcacc ucuucuugcu                                                   20


<210>  10217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10217
caggagaccc aaaaugggua                                                   20


<210>  10218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10218
ggagacccaa aauggguagc                                                   20


<210>  10219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10219
ugagagcugu acugucacuc                                                   20


<210>  10220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10220
uuucugcagg cagaucaucc                                                   20


<210>  10221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10221
ccuucaagcc agggauagac                                                   20


<210>  10222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10222
uggguagaaa ggggcagggu                                                   20


<210>  10223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10223
ugcccuuguu cauggugccc                                                   20


<210>  10224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10224
gugcaggcca gggcacacaa                                                   20


<210>  10225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10225
gccacgccuu ggccucccug                                                   20


<210>  10226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10226
cugccaugcu cauugguguc                                                   20


<210>  10227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10227
uuggugucca aagucuggag                                                   20


<210>  10228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10228
agacuuugga caccaaugag                                                   20


<210>  10229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10229
uggucuuauu cauauuucac                                                   20


<210>  10230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10230
gcucaaugau ucagcagcuu                                                   20


<210>  10231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10231
augauucagc agcuugggca                                                   20


<210>  10232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10232
gggcacuugu agaucaugcu                                                   20


<210>  10233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10233
agauuccaca aguggaaaac                                                   20


<210>  10234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10234
gcucuguacu ccuuuaagag                                                   20


<210>  10235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10235
uaaucuuccc ccucaaaucc                                                   20


<210>  10236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10236
ggacaucuug ugguguggga                                                   20


<210>  10237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10237
cgucccacac cacaagaugu                                                   20


<210>  10238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10238
ggacucacgu cccacaccac                                                   20


<210>  10239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10239
ugaucucagu ugaaauauug                                                   20


<210>  10240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10240
guuuccaaau cuguaaacaa                                                   20


<210>  10241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10241
ccauggcuuc uaaauggcag                                                   20


<210>  10242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10242
gccauuuaga agccauggug                                                   20


<210>  10243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10243
aacagaaaug uuaagauaua                                                   20


<210>  10244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10244
caaauucagg aggauauggc                                                   20


<210>  10245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10245
ugaauuuggg agaaaaaagg                                                   20


<210>  10246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10246
uuccauuuuu uacuacgacc                                                   20


<210>  10247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10247
ugucagccag ugcagugagc                                                   20


<210>  10248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10248
cugcacuggc ugacaggagg                                                   20


<210>  10249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10249
ccaauggaau gucuaagcuc                                                   20


<210>  10250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10250
caggaaaaaa aauccuuuag                                                   20


<210>  10251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10251
ggaaaaaaaa uccuuuagau                                                   20


<210>  10252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10252
auaaaaaaua uauauuuuua                                                   20


<210>  10253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10253
ccauguugcc caggcugguc                                                   20


<210>  10254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10254
ccccaugacc gagccaauua                                                   20


<210>  10255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10255
ccaugaccga gccaauuauu                                                   20


<210>  10256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10256
gucaugggga gaggaauuuu                                                   20


<210>  10257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10257
aaaaguuuac aaaugaccca                                                   20


<210>  10258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10258
acaacaaaaa gacaauccaa                                                   20


<210>  10259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10259
ugcuuaucug uuaagcaucu                                                   20


<210>  10260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10260
cggguucagg cgauucuccu                                                   20


<210>  10261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10261
gccucccggg uucaggcgau                                                   20


<210>  10262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10262
auacaguaaa agucaagaac                                                   20


<210>  10263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10263
cucgauacag uaaaagucaa                                                   20


<210>  10264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10264
ucaggcaguu cugugauacc                                                   20


<210>  10265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10265
aaagaggcac auugaauucu                                                   20


<210>  10266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10266
uuagaguggg uuugguauca                                                   20


<210>  10267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10267
ccacugcauc caagaauuca                                                   20


<210>  10268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10268
auauugagca accacccaau                                                   20


<210>  10269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10269
auauggagau aaacugcuca                                                   20


<210>  10270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10270
ugcuguaauc ccagcauuuu                                                   20


<210>  10271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10271
gccuuccaaa augcugggau                                                   20


<210>  10272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10272
ugauccgccc gccucagccu                                                   20


<210>  10273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10273
ugaccucaug auccgcccgc                                                   20


<210>  10274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10274
aucuccugac cucaugaucc                                                   20


<210>  10275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10275
acuaaaauac aaaaaguuag                                                   20


<210>  10276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10276
caaguagcug ggacuacagg                                                   20


<210>  10277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10277
gccucccaag uagcugggac                                                   20


<210>  10278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10278
ugguucaagu gauuccccug                                                   20


<210>  10279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10279
gccuccuggu ucaagugauu                                                   20


<210>  10280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10280
uuaaaugaau uaguggcauc                                                   20


<210>  10281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10281
gguugaaucc ugacugauac                                                   20


<210>  10282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10282
ggcagaauuu cuuccuccag                                                   20


<210>  10283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10283
aggaagacuc aucucuguuc                                                   20


<210>  10284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10284
ucucuguucu uaacaccuuc                                                   20


<210>  10285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10285
guucuuaaca ccuuccaacu                                                   20


<210>  10286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10286
uaaaaaaaaa aaaaaaaguu                                                   20


<210>  10287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10287
cuauguugcu caggcuggcc                                                   20


<210>  10288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10288
ggcuggccuc gaacucuuga                                                   20


<210>  10289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10289
aacucuugag cucaagugau                                                   20


<210>  10290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10290
ccaaucaggc agaauaugaa                                                   20


<210>  10291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10291
aaucaggcag aauaugaagu                                                   20


<210>  10292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10292
ucaucggcaa cuucauauuc                                                   20


<210>  10293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10293
cgaagugcug ggauuacagg                                                   20


<210>  10294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10294
gccucccgaa gugcugggau                                                   20


<210>  10295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10295
uuccucagcc ucccgaagug                                                   20


<210>  10296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10296
uuagcccagg aguucgagau                                                   20


<210>  10297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10297
ugggcuaaag agauccuccu                                                   20


<210>  10298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10298
aacuccuggg cuaaagagau                                                   20


<210>  10299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10299
cuauguuggc caugcugauc                                                   20


<210>  10300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10300
acaaaaaaau aaacaaaaaa                                                   20


<210>  10301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10301
uuugcauuuu guuugauguc                                                   20


<210>  10302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10302
ugacaucaaa caaaaugcaa                                                   20


<210>  10303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10303
uagaaaauug auucagugua                                                   20


<210>  10304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10304
auauucugaa acuuuaaaua                                                   20


<210>  10305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10305
aacucuauau ucugaaacuu                                                   20


<210>  10306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10306
cuuggacuaa aaauaacauu                                                   20


<210>  10307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10307
uggacuaaaa auaacauuuu                                                   20


<210>  10308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10308
gcuucuucau uuuaggucaa                                                   20


<210>  10309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10309
uuaaauuaca uuuugugucu                                                   20


<210>  10310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10310
cgccuguaau cccggcacuu                                                   20


<210>  10311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10311
caggguucuc aaauauuaaa                                                   20


<210>  10312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10312
ggguucucaa auauuaaaau                                                   20


<210>  10313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10313
aauauuaaaa uucagccaaa                                                   20


<210>  10314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10314
uguucgugga ucagaagacu                                                   20


<210>  10315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10315
ccaaauugau cuauagauuc                                                   20


<210>  10316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10316
ucaauuucaa aacuuaguac                                                   20


<210>  10317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10317
auuucaaaac uuaguacaaa                                                   20


<210>  10318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10318
auuuuucuga aacuaaauag                                                   20


<210>  10319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10319
ugaccucaac ugauccacau                                                   20


<210>  10320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10320
acugauccac auaacucugc                                                   20


<210>  10321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10321
gccucccaaa gugcugggau                                                   20


<210>  10322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10322
aacagguauc ugcacaccca                                                   20


<210>  10323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10323
acuaaaaaua caaaacuauu                                                   20


<210>  10324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10324
gucucuacua aaaauacaaa                                                   20


<210>  10325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10325
aacuccugac uucaggugau                                                   20


<210>  10326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10326
ugacuucagg ugauccaccc                                                   20


<210>  10327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10327
gccucccaaa gugcugggau                                                   20


<210>  10328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10328
agauguugug acagaaugua                                                   20


<210>  10329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10329
uucaguccca aucuacauuc                                                   20


<210>  10330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10330
uccuucaguc ccaaucuaca                                                   20


<210>  10331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10331
aaggcuuuuu uggaaggguu                                                   20


<210>  10332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10332
gcaugaacca cuuaccuagu                                                   20


<210>  10333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10333
ugucacagcg gaggaaacgg                                                   20


<210>  10334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10334
gcugugacau gagugacugu                                                   20


<210>  10335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10335
guuuccuccg cugugacaug                                                   20


<210>  10336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10336
cugggccucc guuuccuccg                                                   20


<210>  10337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10337
uggcucccug ggccuccguu                                                   20


<210>  10338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10338
agagaaagcc agauagagag                                                   20


<210>  10339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10339
gcacacugag gagcugggug                                                   20


<210>  10340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10340
gugugcagag aagccacacc                                                   20


<210>  10341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10341
ucagugugca gagaagccac                                                   20


<210>  10342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10342
cuaaaggaau aagcaucuaa                                                   20


<210>  10343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10343
ggcugggugc cauggcucau                                                   20


<210>  10344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10344
cugauacugg uccugggaua                                                   20


<210>  10345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10345
gauacugguc cugggauauu                                                   20


<210>  10346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10346
guggcauccc agaugaagac                                                   20


<210>  10347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10347
guuuuacaga aggagaaacu                                                   20


<210>  10348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10348
uucuguaaaa cagagauaau                                                   20


<210>  10349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10349
guuucuccuu cuguaaaaca                                                   20


<210>  10350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10350
auagccucag uuucuccuuc                                                   20


<210>  10351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10351
ggucccucag ccagugagug                                                   20


<210>  10352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10352
gccagugagu ggcugaagcc                                                   20


<210>  10353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10353
cuggcugagg gaccugagcc                                                   20


<210>  10354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10354
cucccaagaa gggaaugcau                                                   20


<210>  10355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10355
caagaaggga augcauccuu                                                   20


<210>  10356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10356
agaaaaagau uuuuuaaaau                                                   20


<210>  10357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10357
uagguaguua ugggcaacuc                                                   20


<210>  10358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10358
uauuuuucuc aguuuuuaca                                                   20


<210>  10359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10359
guuuuuacaa uggaaauggc                                                   20


<210>  10360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10360
auuggcuuuu aucaaguuua                                                   20


<210>  10361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10361
ggaggcugag gcugaaggau                                                   20


<210>  10362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10362
ugaguagcug ggacuacagg                                                   20


<210>  10363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10363
gccuccugag uagcugggac                                                   20


<210>  10364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10364
guucucucuu uuuaaaaugg                                                   20


<210>  10365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10365
cuuuuuaaaa uggcagguau                                                   20


<210>  10366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10366
uuuuaaaaug gcagguaucc                                                   20


<210>  10367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10367
aaaacagcau guauaagcaa                                                   20


<210>  10368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10368
aagauguuua uacccagcgc                                                   20


<210>  10369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10369
cgaguagcug ggauuacagg                                                   20


<210>  10370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10370
gccucccgag uagcugggau                                                   20


<210>  10371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10371
auccaggagg cggagguugc                                                   20


<210>  10372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10372
uggauugagg caauuuuccu                                                   20


<210>  10373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10373
gccuccugga uugaggcaau                                                   20


<210>  10374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10374
cugcaaccuc cgccuccugg                                                   20


<210>  10375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10375
agcccuggcg acagagugag                                                   20


<210>  10376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10376
gucgccaggg cuggagugca                                                   20


<210>  10377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10377
cucugucgcc agggcuggag                                                   20


<210>  10378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10378
aucucaaaaa aaaaaaaaaa                                                   20


<210>  10379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10379
aaaaaaaaaa aaaaaaaaaa                                                   20


<210>  10380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10380
uagagcaagu caagagcuau                                                   20


<210>  10381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10381
aagagcaauu aauucaucuu                                                   20


<210>  10382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10382
ugacuugcuc uaagagcaau                                                   20


<210>  10383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10383
agcaggauag cucuugacuu                                                   20


<210>  10384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10384
cucuagcagg auagcucuug                                                   20


<210>  10385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10385
gggacugugg cucccucuag                                                   20


<210>  10386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10386
aaggggaugc ccgggacaaa                                                   20


<210>  10387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10387
uuuauugaac cauucugcuc                                                   20


<210>  10388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10388
gcgcuugucu ucgccucauu                                                   20


<210>  10389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10389
cauugcauug uucuuuuaaa                                                   20


<210>  10390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10390
uugauuaggc aacccguaac                                                   20


<210>  10391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10391
guaaugucua aauguguucu                                                   20


<210>  10392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10392
aaauccgccu uuuccuagaa                                                   20


<210>  10393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10393
ccaaauccgc cuuuuccuag                                                   20


<210>  10394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10394
ccucuccaaa uccgccuuuu                                                   20


<210>  10395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10395
cguuacucac cucuccaaau                                                   20


<210>  10396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10396
ccacccagcu agcagcgcug                                                   20


<210>  10397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10397
ggaccuugcu ccccacccag                                                   20


<210>  10398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10398
cccaguacac uguugccuua                                                   20


<210>  10399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10399
caguacacug uugccuuagu                                                   20


<210>  10400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10400
caguuggcaa agauuauucc                                                   20


<210>  10401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10401
aaauuccaug uggauucuca                                                   20


<210>  10402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10402
uggugacuuc accuuuuacc                                                   20


<210>  10403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10403
uaguucugaa gaagcugguu                                                   20


<210>  10404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10404
gucacuuugc ccagauggaa                                                   20


<210>  10405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10405
guacuaugug aauuugggac                                                   20


<210>  10406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10406
guuuggacac guauguaccu                                                   20


<210>  10407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10407
uaccuacauc aaaagguguu                                                   20


<210>  10408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10408
cagacucacg agggguguuu                                                   20


<210>  10409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10409
cgaggggugu uuuuuuuguu                                                   20


<210>  10410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10410
ugagucugug agucauuucc                                                   20


<210>  10411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10411
aaacaaaaca aaacaaaaca                                                   20


<210>  10412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10412
aucucaaaac aaaacaaaac                                                   20


<210>  10413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10413
uguugccuag acuggagugc                                                   20


<210>  10414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10414
agucuaggca acaagagcga                                                   20


<210>  10415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10415
gcucaccaca accuccgccu                                                   20


<210>  10416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10416
ccacaaccuc cgccuccuga                                                   20


<210>  10417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10417
gccuccugag uucaagcgau                                                   20


<210>  10418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10418
ugaguucaag cgauucuccu                                                   20


<210>  10419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10419
ggaggcggag guugugguga                                                   20


<210>  10420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10420
ugccucagcc ucccgaguag                                                   20


<210>  10421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10421
gccucccgag uagcugguau                                                   20


<210>  10422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10422
cgaguagcug guauuacagg                                                   20


<210>  10423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10423
ggaggcugag gcaggagaau                                                   20


<210>  10424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10424
acuaaaaaua cgaaaauuag                                                   20


<210>  10425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10425
cuacuaaaaa uacgaaaauu                                                   20


<210>  10426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10426
auguugguca ggguggucuu                                                   20


<210>  10427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10427
cgaccucggg ugauccgccc                                                   20


<210>  10428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10428
ggugauccgc ccuccucagc                                                   20


<210>  10429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10429
ucagccuccc aaagugcugg                                                   20


<210>  10430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10430
gccucccaaa gugcugggau                                                   20


<210>  10431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10431
caaagugcug ggauuacagg                                                   20


<210>  10432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10432
cgccuguaau cccagcacuu                                                   20


<210>  10433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10433
uagauggaga ccacuguagu                                                   20


<210>  10434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10434
aucuaggaga cccaucauau                                                   20


<210>  10435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10435
auccaccaac uacagugguc                                                   20


<210>  10436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10436
uuaaaucccc agaccagaac                                                   20


<210>  10437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10437
agguaacuag uaagguaauu                                                   20


<210>  10438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10438
auaugaucac uccagguaac                                                   20


<210>  10439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10439
uagggacuua aaaguucuug                                                   20


<210>  10440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10440
ggagcagguu acacugcccg                                                   20


<210>  10441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10441
ugaguuaaac auacaguauu                                                   20


<210>  10442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10442
gauauuacug cucccauauu                                                   20


<210>  10443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10443
cauauuacaa uucaaaggaa                                                   20


<210>  10444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10444
uaggucagcu uucuaauuaa                                                   20


<210>  10445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10445
ugaaguaaca acuacguugg                                                   20


<210>  10446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10446
gguacaguuc cagagaccau                                                   20


<210>  10447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10447
ggaacuguac cagagggaca                                                   20


<210>  10448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10448
aaucccucca ugauagauau                                                   20


<210>  10449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10449
augauagaua uuucuguaag                                                   20


<210>  10450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10450
guuugaauau guccuagaac                                                   20


<210>  10451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10451
ugcuaaucug ccuuuaauga                                                   20


<210>  10452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10452
gauuuuguga aagaacagag                                                   20


<210>  10453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10453
guucuuucac aaaaucugag                                                   20


<210>  10454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10454
cgccuguaau ccuagcacuu                                                   20


<210>  10455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10455
cgaagugcua ggauuacagg                                                   20


<210>  10456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10456
agcgaucugc cuaccuuggc                                                   20


<210>  10457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10457
auuuaaauau uuaauauaaa                                                   20


<210>  10458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10458
guauaauuau gauuguauag                                                   20


<210>  10459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10459
ggagguguug uacucucagu                                                   20


<210>  10460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10460
agagcaaguc ugugggaaac                                                   20


<210>  10461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10461
cagucaaggc ccagaggcag                                                   20


<210>  10462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10462
gucaaggccc agaggcagug                                                   20


<210>  10463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10463
gggccuugac ugagaguaca                                                   20


<210>  10464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10464
cugccucugg gccuugacug                                                   20


<210>  10465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10465
ccccuacucu gaaugccugu                                                   20


<210>  10466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10466
gaaugccugu cagaaggagc                                                   20


<210>  10467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10467
uucugacagg cauucagagu                                                   20


<210>  10468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10468
ugcggggaca gccucggugc                                                   20


<210>  10469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10469
gugcccuuua auccagauuc                                                   20


<210>  10470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10470
agugggcuug agagagcaaa                                                   20


<210>  10471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10471
agcccacugg aggaagugcu                                                   20


<210>  10472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10472
caagcccacu ggaggaagug                                                   20


<210>  10473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10473
cucaagccca cuggaggaag                                                   20


<210>  10474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10474
gaaaugaauu uguagggucc                                                   20


<210>  10475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10475
ggacccuaca aauucauuuc                                                   20


<210>  10476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10476
cucaggaccc uacaaauuca                                                   20


<210>  10477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10477
auuccuuuac cauugugcuc                                                   20


<210>  10478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10478
gcugucaugg uuuuaggcca                                                   20


<210>  10479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10479
uuccacuaca gucuguggcc                                                   20


<210>  10480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10480
ggucugccca cgucugaagu                                                   20


<210>  10481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10481
ucucuagcag ggaaauaauc                                                   20


<210>  10482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10482
agcagggaaa uaaucggccc                                                   20


<210>  10483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10483
cagcagccug gcgggcaggg                                                   20


<210>  10484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10484
cuggcucaca gcagccuggc                                                   20


<210>  10485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10485
cagcacagug ccuggcacuc                                                   20


<210>  10486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10486
gcacagugcc uggcacucuu                                                   20


<210>  10487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10487
ugucugcuuu ccauucccuu                                                   20


<210>  10488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10488
cccguaauuc caagauaaug                                                   20


<210>  10489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10489
gccagugagg gucucaucaa                                                   20


<210>  10490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10490
cuggcagaga ccagcagcag                                                   20


<210>  10491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10491
ucaagcaaag agcuuccuuu                                                   20


<210>  10492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10492
uugcuugaug agacccucac                                                   20


<210>  10493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10493
uuuauuuugc uguuuaaacu                                                   20


<210>  10494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10494
cacuugacag gcgcaaaccu                                                   20


<210>  10495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10495
ucuuuauucu uuuuuuuugu                                                   20


<210>  10496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10496
aaaugagaaa agaauucugg                                                   20


<210>  10497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10497
uuuagagcca uagcuucacc                                                   20


<210>  10498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10498
agaauucuuu ucucauuuag                                                   20


<210>  10499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10499
ucuuagucuu cacugugcau                                                   20


<210>  10500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10500
uagucuucac ugugcauugu                                                   20


<210>  10501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10501
gcucacgcuc acugaagccg                                                   20


<210>  10502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10502
cgcucacuga agccguggaa                                                   20


<210>  10503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10503
cugaagccgu ggaagucauu                                                   20


<210>  10504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10504
gaaaacaaga aaugacuucc                                                   20


<210>  10505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10505
uuuuaguaac aguuuuguuu                                                   20


<210>  10506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10506
cuucuuucuu auucaaaccu                                                   20


<210>  10507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10507
ucuuucuuau ucaaaccuua                                                   20


<210>  10508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10508
uucuauguuu ucuaagguuu                                                   20


<210>  10509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10509
cauucuguca cucuucacac                                                   20


<210>  10510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10510
ucacaccugc cagcuugcag                                                   20


<210>  10511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10511
gcaagcuggc aggugugaag                                                   20


<210>  10512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10512
agguccauua guuacccgug                                                   20


<210>  10513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10513
ggcuggcugu gauaagggaa                                                   20


<210>  10514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10514
guuugcucuc agccuccagu                                                   20


<210>  10515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10515
cagccuccag ucaauuucuc                                                   20


<210>  10516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10516
gccuccaguc aauuucucug                                                   20


<210>  10517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10517
agucaauuuc ucuggccccu                                                   20


<210>  10518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10518
ggccccuggg acacugugac                                                   20


<210>  10519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10519
agcacagcca agucacagug                                                   20


<210>  10520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10520
cucucucucu cuuuuuuuuu                                                   20


<210>  10521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10521
cucucucucu uuuuuuuuuu                                                   20


<210>  10522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10522
cucucucuuu uuuuuuuuuu                                                   20


<210>  10523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10523
cucucuuuuu uuuuuuuuuu                                                   20


<210>  10524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10524
cucuuuuuuu uuuuuuuuuu                                                   20


<210>  10525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10525
cuuuuuuuuu uuuuuuuuug                                                   20


<210>  10526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10526
uuuuuuuuuu uuuuuuugac                                                   20


<210>  10527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10527
guuguccagg cuggagcgca                                                   20


<210>  10528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10528
agccuggaca acagagcgaa                                                   20


<210>  10529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10529
accuuccagg cccaagugau                                                   20


<210>  10530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10530
aacacuacaa aucauuuuau                                                   20


<210>  10531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10531
aagccauuua uuucuuagcc                                                   20


<210>  10532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10532
gggcuaagaa auaaauggcu                                                   20


<210>  10533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10533
gucacccagg cuggaguaca                                                   20


<210>  10534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10534
cucugucacc caggcuggag                                                   20


<210>  10535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10535
aucuccaaaa aaaaaaaaaa                                                   20


<210>  10536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10536
aaaaaaaaaa aaaaaaaaau                                                   20


<210>  10537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10537
gaaggcugug gugggaggau                                                   20


<210>  10538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10538
caccacagcc uucugaguag                                                   20


<210>  10539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10539
cugcagcccu gaccaccugg                                                   20


<210>  10540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10540
agccugggug acagagugag                                                   20


<210>  10541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10541
gucacccagg cuggagugca                                                   20


<210>  10542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10542
cucugucacc caggcuggag                                                   20


<210>  10543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10543
aaaacaaagc aaaacaaaaa                                                   20


<210>  10544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10544
cccaaggaac cuagagacau                                                   20


<210>  10545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10545
caaggaaccu agagacauuu                                                   20


<210>  10546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10546
agguuccuug ggagaggcca                                                   20


<210>  10547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10547
ugugaauauu cauucaacau                                                   20


<210>  10548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10548
ucuugugaau auucauucaa                                                   20


<210>  10549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10549
ccucuuguga auauucauuc                                                   20


<210>  10550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10550
cuggcccuug aauuaguaag                                                   20


<210>  10551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10551
gcaccucugu uacuguuuua                                                   20


<210>  10552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10552
guuacuguuu uaauacauca                                                   20


<210>  10553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10553
ggaggcugag gcaggagaau                                                   20


<210>  10554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10554
cgaguagcug ggauuauagg                                                   20


<210>  10555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10555
gccucccgag uagcugggau                                                   20


<210>  10556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10556
ugccucagcc ucccgaguag                                                   20


<210>  10557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10557
cagguuucaa gcgauucucc                                                   20


<210>  10558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10558
gucucccagg uuucaagcga                                                   20


<210>  10559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10559
cugcaaccuc ugucucccag                                                   20


<210>  10560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10560
gcucacugca accucugucu                                                   20


<210>  10561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10561
agccugggcg acagagcaag                                                   20


<210>  10562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10562
ccauuaugaa uggaggggau                                                   20


<210>  10563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10563
auucauaaug gugagcacca                                                   20


<210>  10564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10564
ucaaagccgg gauugcccag                                                   20


<210>  10565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10565
gcucaucaaa gccgggauug                                                   20


<210>  10566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10566
cugcucauca aagccgggau                                                   20


<210>  10567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10567
gcagcauaga aaacggcucu                                                   20


<210>  10568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10568
guaaaucuuc caagccgcaa                                                   20


<210>  10569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10569
auuagguagc accguucuua                                                   20


<210>  10570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10570
aagacuugca ggcuccauua                                                   20


<210>  10571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10571
cagcccuagg cuucccuggu                                                   20


<210>  10572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10572
ugcccauccu ggaagcagcc                                                   20


<210>  10573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10573
cagcuauucu ccugcccauc                                                   20


<210>  10574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10574
auggugauuc uuaggguugg                                                   20


<210>  10575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10575
gacuggccau auuuccaaua                                                   20


<210>  10576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10576
agucccugau auaaaauggu                                                   20


<210>  10577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10577
cuugucaccu uguaagccug                                                   20


<210>  10578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10578
uggccuuugu gaugcagcuc                                                   20


<210>  10579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10579
ccacagagcc cuccagccuu                                                   20


<210>  10580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10580
guggggagcu gcaucacaaa                                                   20


<210>  10581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10581
agccuugggu ccugcugcuc                                                   20


<210>  10582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10582
cacacccccu gcccucauca                                                   20


<210>  10583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10583
ucaugcgagg guuuuagcug                                                   20


<210>  10584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10584
caugaugagg gcagggggug                                                   20


<210>  10585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10585
gguguccuca cuucauugua                                                   20


<210>  10586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10586
cuucauugua ccuuugcaca                                                   20


<210>  10587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10587
ccacccagcc ccucuuccug                                                   20


<210>  10588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10588
acccagcccc ucuuccuguc                                                   20


<210>  10589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10589
uccugucauu cugagagacu                                                   20


<210>  10590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10590
gaaugacagg aagaggggcu                                                   20


<210>  10591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10591
cagaaugaca ggaagagggg                                                   20


<210>  10592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10592
ugcucauccg cccagaguug                                                   20


<210>  10593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10593
uccgcccaga guuggcccac                                                   20


<210>  10594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10594
gggcggauga gcaggagucu                                                   20


<210>  10595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10595
ugcugugugg gccaacucug                                                   20


<210>  10596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10596
cacccucgug cugugugggc                                                   20


<210>  10597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10597
ugcucacacc cucgugcugu                                                   20


<210>  10598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10598
cccacauccu ccaacugcuc                                                   20


<210>  10599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10599
aacugcuccc cguguugucu                                                   20


<210>  10600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10600
ccguguuguc ugcucagaug                                                   20


<210>  10601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10601
gauggucacg ucagacgaug                                                   20


<210>  10602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10602
ucgucugacg ugaccaucug                                                   20


<210>  10603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10603
caagaagcuc aucgucugac                                                   20


<210>  10604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10604
uuucuuccua uucugaugga                                                   20


<210>  10605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10605
uuaucuuaua uaucccacag                                                   20


<210>  10606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10606
uaaggaccag agaccaggcu                                                   20


<210>  10607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10607
gguccuuaag agauauuuau                                                   20


<210>  10608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10608
gcaccuugag cauugagcaa                                                   20


<210>  10609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10609
aggugcggag gugucagccc                                                   20


<210>  10610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10610
augcucaagg ugcggaggug                                                   20


<210>  10611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10611
uagccagggc agcaauccac                                                   20


<210>  10612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10612
agacacagag guggucgccu                                                   20


<210>  10613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10613
gugucuagag gacucauagc                                                   20


<210>  10614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10614
ggcgaccacc ucugugucua                                                   20


<210>  10615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10615
acucaggcga ccaccucugu                                                   20


<210>  10616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10616
aagcaauggc aacaaggcuu                                                   20


<210>  10617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10617
uaccucuaag caauggcaac                                                   20


<210>  10618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10618
uaugggugug uuccaugguc                                                   20


<210>  10619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10619
uggaguaaau cacacuucac                                                   20


<210>  10620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10620
aggaguaaca aaagaaucaa                                                   20


<210>  10621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10621
gccguaguca ccugugaagu                                                   20


<210>  10622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10622
agaugagcug gauuuucuca                                                   20


<210>  10623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10623
ucuugagacu gaaaccaaac                                                   20


<210>  10624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10624
ugugagcuuu ggcucauccu                                                   20


<210>  10625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10625
caugagaaaa uccagcucau                                                   20


<210>  10626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10626
uccucuaacc uccgguaccc                                                   20


<210>  10627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10627
aaccuccggu acccacuugc                                                   20


<210>  10628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10628
gguacccacu ugccucaccc                                                   20


<210>  10629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10629
cccgccugca cucagugggg                                                   20


<210>  10630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10630
gugggggcug caccaugucu                                                   20


<210>  10631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10631
ccaucaguag guaucacuaa                                                   20


<210>  10632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10632
gcccccugag uagcugggac                                                   20


<210>  10633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10633
gggggcugag gugggaaugu                                                   20


<210>  10634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10634
agcugggugc aguggugugu                                                   20


<210>  10635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10635
uaccauuaac auauuuuuaa                                                   20


<210>  10636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10636
caugugacga caguguaaaa                                                   20


<210>  10637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10637
gcaaacaacu cacaugugac                                                   20


<210>  10638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10638
ugaagggcag uuucguguuu                                                   20


<210>  10639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10639
cgcugguugu uccuacuggg                                                   20


<210>  10640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10640
ggaaucacag ugccaacuuc                                                   20


<210>  10641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10641
acaagaaaca acaacaaaag                                                   20


<210>  10642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10642
ggcuucaagu cucuacaaga                                                   20


<210>  10643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10643
uugaugaucg ugguaagugg                                                   20


<210>  10644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10644
aacaaagucu acccauuaga                                                   20


<210>  10645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10645
uaaucauuaa guccacuuuc                                                   20


<210>  10646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10646
ccuaaucauu aaguccacuu                                                   20


<210>  10647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10647
gugguaugug uucauuuuaa                                                   20


<210>  10648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10648
gcuucuugcc uaaacacagg                                                   20


<210>  10649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10649
aucauuaauu gaaaauuaug                                                   20


<210>  10650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10650
agccugggcg acacagcaag                                                   20


<210>  10651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10651
cugcagccuu gaacuacugg                                                   20


<210>  10652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10652
aaugacccuc ccaucucagc                                                   20


<210>  10653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10653
caucucagcu uucugcauag                                                   20


<210>  10654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10654
gcuuucugca uagcugggac                                                   20


<210>  10655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10655
acaaaaaaaa uuuaaaaauu                                                   20


<210>  10656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10656
aacuacugcc cucaagcagu                                                   20


<210>  10657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10657
agcaguccuc cugccuuccc                                                   20


<210>  10658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10658
ugccuucccu cccaaagcac                                                   20


<210>  10659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10659
caaagcacua ggguuacagg                                                   20


<210>  10660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10660
cucuuguuuc uugcuguuga                                                   20


<210>  10661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10661
uguuucuugc uguugaccca                                                   20


<210>  10662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10662
ugcuuuauuc uuuuuuauuu                                                   20


<210>  10663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10663
aaacuuuguc auguugcccc                                                   20


<210>  10664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10664
ugucacauag caugugucac                                                   20


<210>  10665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10665
gugacacaug cuaugugaca                                                   20


<210>  10666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10666
aagcagccau cugcacccug                                                   20


<210>  10667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10667
cuguccacua uuacaggguc                                                   20


<210>  10668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10668
uugucugcag caugggugca                                                   20


<210>  10669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10669
accuugguuc cucuaaggga                                                   20


<210>  10670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10670
aagggagagu cauacccaga                                                   20


<210>  10671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10671
cuuagaggaa ccaaggugga                                                   20


<210>  10672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10672
cccuuagagg aaccaaggug                                                   20


<210>  10673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10673
ccagcagugc aaccauccuu                                                   20


<210>  10674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10674
cacauagcuc acaagcagug                                                   20


<210>  10675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10675
caagcagugc ugggagagag                                                   20


<210>  10676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10676
cagcacugcu ugugagcuau                                                   20


<210>  10677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10677
cccagcacug cuugugagcu                                                   20


<210>  10678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10678
cucccagcac ugcuugugag                                                   20


<210>  10679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10679
cuugaaagaa gcucucuccc                                                   20


<210>  10680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10680
acuagacugu aagacccuuc                                                   20


<210>  10681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10681
ugccgagaag aggacaggcg                                                   20


<210>  10682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10682
gcaggagcca cugaccuugc                                                   20


<210>  10683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10683
ucucggcagg agccacugac                                                   20


<210>  10684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10684
gccuuagacg ccuguccucu                                                   20


<210>  10685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10685
aucuccgccu uagacgccug                                                   20


<210>  10686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10686
uuuuaugccu cugccagaug                                                   20


<210>  10687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10687
gccagaugcu uucaugcuua                                                   20


<210>  10688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10688
cagggcaggg ugucauacau                                                   20


<210>  10689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10689
uuccucacag ggcagggugu                                                   20


<210>  10690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10690
uuuaauggaa ggcgauacca                                                   20


<210>  10691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10691
ugacuuagcc ugugguucau                                                   20


<210>  10692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10692
ccagaggugg cuuugggugg                                                   20


<210>  10693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10693
ggugagcagc acagcaccag                                                   20


<210>  10694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10694
ccacccaaag ccaccucugg                                                   20


<210>  10695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10695
cuuacugagu uguuaaaagg                                                   20


<210>  10696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10696
guaagugagc agcuucgcuu                                                   20


<210>  10697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10697
guaugcaaag uggagcaauc                                                   20


<210>  10698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10698
acuuugcaua cagagcacgu                                                   20


<210>  10699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10699
aagcuaugug guugaucgga                                                   20


<210>  10700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10700
gcaccguacc cuguuccgau                                                   20


<210>  10701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10701
cuuuugugua aacaaagcag                                                   20


<210>  10702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10702
uaaacauaaa gaaacauaaa                                                   20


<210>  10703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10703
ugauuguccc uuuauguuuc                                                   20


<210>  10704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10704
ccugccuugu uaucacuucu                                                   20


<210>  10705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10705
uaaaaacaca gaaaaagguu                                                   20


<210>  10706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10706
cuucuuuaga acuuuacccc                                                   20


<210>  10707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10707
ucuuuagaac uuuaccccac                                                   20


<210>  10708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10708
aacauguggg guaaaguucu                                                   20


<210>  10709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10709
gcucaaacau gugggguaaa                                                   20


<210>  10710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10710
ugccuggcua acuuagcaag                                                   20


<210>  10711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10711
gcccagguuc cccuccugcg                                                   20


<210>  10712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10712
ugcgccacga ucugaaaggc                                                   20


<210>  10713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10713
cgggugggau gccaggaugg                                                   20


<210>  10714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10714
ucucuugggg accacagucc                                                   20


<210>  10715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10715
uggggaccac aguccucuga                                                   20


<210>  10716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10716
gaugccgaug accacaguuu                                                   20


<210>  10717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10717
cuaugcuacc caggcugggu                                                   20


<210>  10718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10718
augcuaccca ggcugggugc                                                   20


<210>  10719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10719
caggugcgau uguggcacaa                                                   20


<210>  10720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10720
ugggccuaag cgacccuccu                                                   20


<210>  10721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10721
ugccucagcc ucccacguag                                                   20


<210>  10722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10722
gccucccacg uagcuggagu                                                   20


<210>  10723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10723
cacguagcug gaguuucagg                                                   20


<210>  10724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10724
agcuacgugg gaggcugagg                                                   20


<210>  10725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10725
cugcaguuuu gaccuccagg                                                   20


<210>  10726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10726
agggcuguag cgauccgccu                                                   20


<210>  10727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10727
gccuccugag uagcugggaa                                                   20


<210>  10728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10728
ugaguagcug ggaauacagg                                                   20


<210>  10729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10729
ggaggcugag gcaaggcgga                                                   20


<210>  10730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10730
ugccuguauu cccagcuacu                                                   20


<210>  10731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10731
caaaguacua ggauuauagg                                                   20


<210>  10732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10732
gccucccaaa guacuaggau                                                   20


<210>  10733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10733
agugauccac cugccucagc                                                   20


<210>  10734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10734
ugaccucaag ugauccaccu                                                   20


<210>  10735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10735
aacucuugac cucaagugau                                                   20


<210>  10736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10736
acuaaaaaua caaaaauuag                                                   20


<210>  10737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10737
aaucccagcu acucaggagg                                                   20


<210>  10738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10738
ggaggccgag gcaggagaau                                                   20


<210>  10739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10739
ugaguagcug ggauuagagg                                                   20


<210>  10740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10740
gccuccugag uagcugggau                                                   20


<210>  10741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10741
ugccucggcc uccugaguag                                                   20


<210>  10742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10742
gccgcccggg uucaagcgau                                                   20


<210>  10743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10743
cugcaaccuc ugccgcccgg                                                   20


<210>  10744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10744
gcucacugca accucugccg                                                   20


<210>  10745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10745
agccugggcg acagagugag                                                   20


<210>  10746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10746
gucgcccagg cuggagugua                                                   20


<210>  10747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10747
cucugucgcc caggcuggag                                                   20


<210>  10748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10748
gucucaaaaa acaaacaaac                                                   20


<210>  10749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10749
aaaaacaaac aaacaaacaa                                                   20


<210>  10750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10750
aauuaauuua aagucacuca                                                   20


<210>  10751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10751
gaggccgggc acaguggcuc                                                   20


<210>  10752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10752
gagugacuuu aaauuaauuu                                                   20


<210>  10753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10753
ugccuguaau cccaauauuu                                                   20


<210>  10754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10754
caaaauauug ggauuacagg                                                   20


<210>  10755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10755
ugacuucagg ugauccaccu                                                   20


<210>  10756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10756
acuaaaaaua caaaaauuag                                                   20


<210>  10757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10757
aguagcuggg acuacaggca                                                   20


<210>  10758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10758
gccccucaag uagcugggac                                                   20


<210>  10759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10759
cagguucaag cgauucuucu                                                   20


<210>  10760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10760
gccucccagg uucaagcgau                                                   20


<210>  10761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10761
cugcaaccuc cgccucccag                                                   20


<210>  10762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10762
agccuaggug acagagugag                                                   20


<210>  10763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10763
gucaccuagg cuggagugca                                                   20


<210>  10764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10764
cucugucacc uaggcuggag                                                   20


<210>  10765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10765
gucucaaaaa aaaaaaaaaa                                                   20


<210>  10766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10766
aaaaaaaaaa aaaaaaaagu                                                   20


<210>  10767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10767
guaucauucc cuucugugcg                                                   20


<210>  10768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10768
aaaaaaaaaa aaaaaaaaau                                                   20


<210>  10769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10769
gucucaaaaa aaaaaaaaaa                                                   20


<210>  10770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10770
gucgcccagg cuggugugca                                                   20


<210>  10771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10771
gcucacugua agcuccgccu                                                   20


<210>  10772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10772
cuguaagcuc cgccucccag                                                   20


<210>  10773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10773
gccucccagg uucaugccau                                                   20


<210>  10774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10774
cagguucaug ccauucuccu                                                   20


<210>  10775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10775
ugccucagcc ucccaagcag                                                   20


<210>  10776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10776
gccucccaag cagcugggac                                                   20


<210>  10777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10777
caagcagcug ggacuacagg                                                   20


<210>  10778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10778
acuaaaaaaa auauaaaaaa                                                   20


<210>  10779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10779
aucuccugac cuugugaucc                                                   20


<210>  10780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10780
ugaccuugug auccgcccgc                                                   20


<210>  10781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10781
gccucccaaa gugcugggau                                                   20


<210>  10782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10782
caaagugcug ggauuacagg                                                   20


<210>  10783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10783
agccuguaau cccagcacuu                                                   20


<210>  10784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10784
auuuugcggu guuaucuuug                                                   20


<210>  10785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10785
uauuucauuc cuucauuuac                                                   20


<210>  10786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10786
uuucuuaaau aaaguaguag                                                   20


<210>  10787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10787
acguggcuau uucacugaau                                                   20


<210>  10788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10788
accguauauu cagugaaaua                                                   20


<210>  10789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10789
gcaacacuca uggacggcuu                                                   20


<210>  10790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10790
uggacggcuu ccguccgucu                                                   20


<210>  10791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10791
ugcaggcgaa ccugaccugu                                                   20


<210>  10792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10792
cugguaagcg ugucaucucc                                                   20


<210>  10793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10793
accggugcug uuuccguugg                                                   20


<210>  10794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10794
aucgcggcac caacggaaac                                                   20


<210>  10795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10795
ccaucgcggc accaacggaa                                                   20


<210>  10796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10796
aucaaggaua cauucaacga                                                   20


<210>  10797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10797
aggguguuuc ccgucugcau                                                   20


<210>  10798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10798
ugcacugcug gugggaaugc                                                   20


<210>  10799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10799
cgugcacugc uggugggaau                                                   20


<210>  10800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10800
ccagcagacc gaguucucga                                                   20


<210>  10801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10801
gucugcuggc gaggcugugg                                                   20


<210>  10802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10802
aacuuuggag uuuuugucag                                                   20


<210>  10803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10803
aaaguucgag aacucggucu                                                   20


<210>  10804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10804
guuuaaaaau ccauuuuuau                                                   20


<210>  10805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10805
acuuaaauga aaaauacacg                                                   20


<210>  10806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10806
cgccuguaau cccagcacuu                                                   20


<210>  10807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10807
caaagugcug ggauuacagg                                                   20


<210>  10808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10808
cacccuggcc ucccaaagug                                                   20


<210>  10809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10809
agcgauccuc ccacccuggc                                                   20


<210>  10810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10810
ugggcucaag cgauccuccc                                                   20


<210>  10811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10811
acaaaagaaa agaaaagaaa                                                   20


<210>  10812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10812
ccuuguacag augcauucuu                                                   20


<210>  10813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10813
guuuccuccc cuuguacaga                                                   20


<210>  10814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10814
gccauguacu aucaugucuc                                                   20


<210>  10815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10815
gacccacgcc aucgggcugg                                                   20


<210>  10816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10816
ucaccccugu gcucucccgc                                                   20


<210>  10817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10817
ccccugugcu cucccgccuc                                                   20


<210>  10818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10818
cccgccuccc agggugggcg                                                   20


<210>  10819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10819
cgccucccag ggugggcgcg                                                   20


<210>  10820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10820
cagggugggc gcgcagcaag                                                   20


<210>  10821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10821
gaugcaugca cgugauacac                                                   20


<210>  10822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10822
gacucagaug caugcacgug                                                   20


<210>  10823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10823
cuaaagcauc augcagacug                                                   20


<210>  10824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10824
aaagcaucau gcagacuguu                                                   20


<210>  10825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10825
aaggcacugu agucauuuua                                                   20


<210>  10826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10826
auaaauauuu auuggugaaa                                                   20


<210>  10827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10827
gcuucuaaua ucauacccug                                                   20


<210>  10828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10828
acagaauguu uucgauaauu                                                   20


<210>  10829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10829
aaaaaauuau aaagaaaaua                                                   20


<210>  10830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10830
cucuugcccu gcaguggugu                                                   20


<210>  10831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10831
ugcccugcag uggugugauc                                                   20


<210>  10832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10832
accuucuggg cuuaagcgau                                                   20


<210>  10833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10833
ugccucagcc uccagaguag                                                   20


<210>  10834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10834
gccuccagag uagcugggac                                                   20


<210>  10835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10835
agaguagcug ggaccauagc                                                   20


<210>  10836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10836
ggaggcugag gcaggaggau                                                   20


<210>  10837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10837
auaaaaaaag auuuuuaaaa                                                   20


<210>  10838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10838
aaauguggaa cucaaguaau                                                   20


<210>  10839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10839
aguaauccuc cgaccuuggc                                                   20


<210>  10840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10840
gaccuuggcc ucccaaagug                                                   20


<210>  10841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10841
caaagugcug gaauuacagg                                                   20


<210>  10842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10842
auuaccauuu guucucaaga                                                   20


<210>  10843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10843
agagaauaac uccauaucau                                                   20


<210>  10844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10844
ugagaacaaa ugguaauaga                                                   20


<210>  10845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10845
auaucauuca uguguagcug                                                   20


<210>  10846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10846
gacagaaagu auuuauuuac                                                   20


<210>  10847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10847
ggaacaguaa acguaaaaug                                                   20


<210>  10848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10848
aaaaccaugg cuggaaauaa                                                   20


<210>  10849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10849
guuuggccac agagauccca                                                   20


<210>  10850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10850
guggccaaac cgaggucuga                                                   20


<210>  10851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10851
guccuucugg gaucucugug                                                   20


<210>  10852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10852
aacccucugu ccuucuggga                                                   20


<210>  10853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10853
uccucgaacc cucuguccuu                                                   20


<210>  10854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10854
cgaacccaug uagccgacug                                                   20


<210>  10855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10855
cacgaaccca uguagccgac                                                   20


<210>  10856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10856
ggcacccgga uagaaaggac                                                   20


<210>  10857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10857
gaacacagag aaauccaccc                                                   20


<210>  10858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10858
guguucugag gcacucaggc                                                   20


<210>  10859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10859
guuuggacac acuaguagau                                                   20


<210>  10860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10860
aaccugucag aguguugagg                                                   20


<210>  10861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10861
gacagguuag agauucaaaa                                                   20


<210>  10862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10862
acacucugac agguuagaga                                                   20


<210>  10863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10863
gcuucuuaca gaugaggggu                                                   20


<210>  10864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10864
ucuguaagaa gcugagggca                                                   20


<210>  10865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10865
ccccucaucu guaagaagcu                                                   20


<210>  10866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10866
ggccucaccc cucaucugua                                                   20


<210>  10867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10867
caggccucac cccucaucug                                                   20


<210>  10868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10868
caaccucuca ggccucaccc                                                   20


<210>  10869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10869
ggacucacaa ccucucaggc                                                   20


<210>  10870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10870
gcgaagugag ggcagaaucg                                                   20


<210>  10871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10871
cuucgcugag ugaccucagg                                                   20


<210>  10872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10872
ucacucuacc aguguccucc                                                   20


<210>  10873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10873
cucuaccagu guccuccccu                                                   20


<210>  10874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10874
accagugucc uccccugugc                                                   20


<210>  10875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10875
ccugugcacc acggccucuc                                                   20


<210>  10876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10876
cggagccuca ggaaaucacc                                                   20


<210>  10877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10877
gagccucagg aaaucacccc                                                   20


<210>  10878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10878
gagaggccgu ggugcacagg                                                   20


<210>  10879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10879
ggaaaucacc ccacucuggu                                                   20


<210>  10880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10880
gguuauucca aagauccggg                                                   20


<210>  10881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10881
gagagccucg cagaguccug                                                   20


<210>  10882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10882
gaggccaccc cuggggguug                                                   20


<210>  10883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10883
cagaggccac cccugggggu                                                   20


<210>  10884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10884
cagaguccug caggaagacc                                                   20


<210>  10885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10885
gcgaggcucu cagaggccac                                                   20


<210>  10886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10886
ugcgucuugu gggguuuuuc                                                   20


<210>  10887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10887
gugugucugg agggagcccc                                                   20


<210>  10888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10888
agacacacag agccaugccc                                                   20


<210>  10889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10889
cuccagacac acagagccau                                                   20


<210>  10890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10890
ugaaggggcu cccuccagac                                                   20


<210>  10891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10891
accuccugaa ggggcucccu                                                   20


<210>  10892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10892
guggcaauuc agcucaucuu                                                   20


<210>  10893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10893
ucuuggauga aucauacaaa                                                   20


<210>  10894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10894
gugaaaauac uaaaauccgu                                                   20


<210>  10895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10895
aaaaaaaaaa aaaguuguga                                                   20


<210>  10896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10896
gucucaaaaa aaaaaaaaag                                                   20


<210>  10897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10897
cucagucgcc caggcuagaa                                                   20


<210>  10898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10898
gucgcccagg cuagaaugca                                                   20


<210>  10899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10899
cugcaacguc caccucccag                                                   20


<210>  10900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10900
caggcacaag cgauucuccu                                                   20


<210>  10901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10901
ugccucagcu uccugaguau                                                   20


<210>  10902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10902
gcuuccugag uaucuggaac                                                   20


<210>  10903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10903
ggaagcugag gcaggagaau                                                   20


<210>  10904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10904
acuaaaaaua caaaaauuag                                                   20


<210>  10905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10905
aacuccugau cucaggugau                                                   20


<210>  10906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10906
ugaucucagg ugaucugccu                                                   20


<210>  10907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10907
ggugaucugc cugccuucgc                                                   20


<210>  10908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10908
caaaaugcug ggauuauagg                                                   20


<210>  10909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10909
caccuauaau cccagcauuu                                                   20


<210>  10910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10910
cagccuuaac auaauguuuu                                                   20


<210>  10911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10911
auucaaaaaa uacaaagaga                                                   20


<210>  10912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10912
uuguauuuuu ugaauggaga                                                   20


<210>  10913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10913
cauuugacuu ucucuuugua                                                   20


<210>  10914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10914
ucccauuuga cuuucucuuu                                                   20


<210>  10915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10915
guaucauucu ugauucuuug                                                   20


<210>  10916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10916
ucgguaucau ucuugauucu                                                   20


<210>  10917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10917
gaauacuccu cgguaucauu                                                   20


<210>  10918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10918
gaaaacuucu cagaauacuc                                                   20


<210>  10919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10919
guagaggcug ggaaauggca                                                   20


<210>  10920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10920
acagagccug acuuaccauc                                                   20


<210>  10921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10921
cucauucuag uuguuuucac                                                   20


<210>  10922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10922
uucuaguugu uuucacuggc                                                   20


<210>  10923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10923
caggcccugc cccugccccu                                                   20


<210>  10924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10924
cuacugggcu gcaggggcag                                                   20


<210>  10925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10925
ugaacacgcg uguccucccu                                                   20


<210>  10926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10926
gguccaccug ugucuuggcc                                                   20


<210>  10927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10927
cugcugggcc aagacacagg                                                   20


<210>  10928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10928
ugaacacacg uguccucccu                                                   20


<210>  10929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10929
gguccaccug ucuccuggcc                                                   20


<210>  10930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10930
uggcccagca gggaggacac                                                   20


<210>  10931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10931
cugcugggcc aggagacagg                                                   20


<210>  10932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10932
ugaacacgcg uguccucccu                                                   20


<210>  10933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10933
gguccaccug ccuccuggcc                                                   20


<210>  10934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10934
uggcccagca gggaggacac                                                   20


<210>  10935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10935
cugcugggcc aggaggcagg                                                   20


<210>  10936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10936
ggaggcucac gucaaccugu                                                   20


<210>  10937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10937
ugagcacaug uguccucccu                                                   20


<210>  10938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10938
cgucaaccug ucucuuggcc                                                   20


<210>  10939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10939
uggcccagca gggaggacac                                                   20


<210>  10940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10940
cugcugggcc aagagacagg                                                   20


<210>  10941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10941
cgucuaccug ccuccuuccc                                                   20


<210>  10942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10942
uuccccaugc uccugccacu                                                   20


<210>  10943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10943
ugccacuggg auuucaucag                                                   20


<210>  10944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10944
uuuugucuga ugaaauccca                                                   20


<210>  10945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10945
cuggcucuuu uugucugaug                                                   20


<210>  10946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10946
aaucaaaacc caauuaaguc                                                   20


<210>  10947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10947
aauaaugcua cugaaaggga                                                   20


<210>  10948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10948
ucccuuucag uagcauuauu                                                   20


<210>  10949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10949
aaauacauga aagauugguu                                                   20


<210>  10950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10950
gggacuacaa ucccuggcag                                                   20


<210>  10951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10951
gaccugaggg ccuucugugu                                                   20


<210>  10952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10952
ggucagagug ucucugggac                                                   20


<210>  10953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10953
gggccuggug cuggacagac                                                   20


<210>  10954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10954
gaggcugacg guggcacccg                                                   20


<210>  10955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10955
gaggcccuua gcacaguuaa                                                   20


<210>  10956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10956
cgggugccac cgucagccuc                                                   20


<210>  10957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10957
uugcugugac ucgcgggugc                                                   20


<210>  10958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10958
ucuccuugcu gugacucgcg                                                   20


<210>  10959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10959
accgcuuggg gcucaucucc                                                   20


<210>  10960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10960
uucugggacc agggaccagg                                                   20


<210>  10961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10961
gggacuggac uguguuacca                                                   20


<210>  10962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10962
cugcccagac acucaaucag                                                   20


<210>  10963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10963
aucagugagg gaaacucucu                                                   20


<210>  10964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10964
cugauugagu gucugggcag                                                   20


<210>  10965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10965
cuuuguuacu uacuuuaaac                                                   20


<210>  10966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10966
uuguuacuua cuuuaaacca                                                   20


<210>  10967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10967
auaaauccuu guugaaugaa                                                   20


<210>  10968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10968
cuggcagggc ggggacuucu                                                   20


<210>  10969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10969
ccacagccca cacgucuaug                                                   20


<210>  10970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10970
ggaggacggg gaacugccug                                                   20


<210>  10971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10971
agagugcggg uccuccccac                                                   20


<210>  10972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10972
aggcaguucc ccguccucca                                                   20


<210>  10973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10973
agggggugag agggggucgg                                                   20


<210>  10974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10974
cccccuagag ccugccgccc                                                   20


<210>  10975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10975
cacccccuag agccugccgc                                                   20


<210>  10976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10976
gcccagcagg ccgacccccu                                                   20


<210>  10977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10977
gucugcucug cccagcaggc                                                   20


<210>  10978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10978
ugccagcagc cugccacugu                                                   20


<210>  10979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10979
ugcucuugcc agcagccugc                                                   20


<210>  10980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10980
aacccccucc ugcucuugcc                                                   20


<210>  10981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10981
gucccguccc ccucuaaccc                                                   20


<210>  10982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10982
cugucccguc ccccucuaac                                                   20


<210>  10983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10983
aggcuugaca augaugacaa                                                   20


<210>  10984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10984
gauggccaug aagccaucgc                                                   20


<210>  10985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10985
gugaagagug augugaugag                                                   20


<210>  10986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10986
ucacagagcc cugcgauggc                                                   20


<210>  10987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10987
ucacaucacu cuucacagag                                                   20


<210>  10988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10988
caguggccgg caagcccagu                                                   20


<210>  10989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10989
cccaguggcc ggcaagccca                                                   20


<210>  10990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10990
cuguccauuc auucucuccc                                                   20


<210>  10991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10991
ucccugucca uucauucucu                                                   20


<210>  10992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10992
ccugaaucgc ugcaaagccc                                                   20


<210>  10993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10993
caccugaauc gcugcaaagc                                                   20


<210>  10994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10994
gugauggcag agcaggugug                                                   20


<210>  10995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10995
gccaucaccg aggucugcgu                                                   20


<210>  10996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10996
caccugcucu gccaucaccg                                                   20


<210>  10997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10997
accaccugcc uucaggaucc                                                   20


<210>  10998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10998
aagaugggcu ggagggaagg                                                   20


<210>  10999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  10999
agcccaucuu ggagucagcc                                                   20


<210>  11000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11000
cuggagccaa guccuugcag                                                   20


<210>  11001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11001
agcgagugcc cccuucccuc                                                   20


<210>  11002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11002
ccacugcaag gacuuggcuc                                                   20


<210>  11003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11003
ccgugcgcug gcugcugucc                                                   20


<210>  11004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11004
agugaccgga gaggaggcag                                                   20


<210>  11005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11005
ggucacugga ggaacugccc                                                   20


<210>  11006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11006
ccggucacug gaggaacugc                                                   20


<210>  11007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11007
ucuccgguca cuggaggaac                                                   20


<210>  11008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11008
gccuccucuc cggucacugg                                                   20


<210>  11009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11009
ccagcugugc ugcacuggcc                                                   20


<210>  11010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11010
cgucucccca gcugugcugc                                                   20


<210>  11011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11011
uauggagcuu cuuuuucuca                                                   20


<210>  11012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11012
auaagagacc guucacagcc                                                   20


<210>  11013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11013
gauggucagc cccuaguggg                                                   20


<210>  11014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11014
ccacuagggg cugaccaucu                                                   20


<210>  11015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11015
caccuuugcu ccccacuagg                                                   20


<210>  11016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11016
caccugccuc ccaccuuugc                                                   20


<210>  11017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11017
ccuuuccuca caccugccuc                                                   20


<210>  11018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11018
acagcaucaa gagcccaugc                                                   20


<210>  11019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11019
ugaugcuguu gaggaaaccc                                                   20


<210>  11020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11020
cuucaggucc gcaugggcuc                                                   20


<210>  11021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11021
ccucccuuca gguccgcaug                                                   20


<210>  11022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11022
gagccagcag ggagcugcac                                                   20


<210>  11023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11023
gagccugcac cguccaggug                                                   20


<210>  11024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11024
cugcuggcuc ugagccugca                                                   20


<210>  11025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11025
cccagcucug guuuguccag                                                   20


<210>  11026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11026
gguuugucca gcagcuagag                                                   20


<210>  11027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11027
agcugcugga caaaccagag                                                   20


<210>  11028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11028
cuagcugcug gacaaaccag                                                   20


<210>  11029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11029
cucuagcugc uggacaaacc                                                   20


<210>  11030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11030
ccggccucuc ucuagcugcu                                                   20


<210>  11031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11031
cuggcaugca gcccagcucc                                                   20


<210>  11032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11032
agucacuccc uggcaugcag                                                   20


<210>  11033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11033
acgcuggcuc caguggacga                                                   20


<210>  11034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11034
aguggacgag gaaauggaca                                                   20


<210>  11035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11035
uccacuggag ccagcgucga                                                   20


<210>  11036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11036
caacuuggac caugcuuugc                                                   20


<210>  11037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11037
aggccagagu uagaaagaug                                                   20


<210>  11038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11038
ggccuggagg uguauggacu                                                   20


<210>  11039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11039
ucuuucuaac ucuggccugg                                                   20


<210>  11040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11040
caucuuucua acucuggccu                                                   20


<210>  11041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11041
gagaggaagc ugcuuggagu                                                   20


<210>  11042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11042
gagcgucccu cucaucuuuc                                                   20


<210>  11043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11043
cugagcgucc cucucaucuu                                                   20


<210>  11044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11044
aagcagcuuc cucucugagc                                                   20


<210>  11045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11045
acuccaagca gcuuccucuc                                                   20


<210>  11046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11046
gucagcucca cuccaagcag                                                   20


<210>  11047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11047
uggccagcaa gcacucuguc                                                   20


<210>  11048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11048
cuggucacac cccagacucu                                                   20


<210>  11049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11049
cccuggucac accccagacu                                                   20


<210>  11050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11050
cucccugguc acaccccaga                                                   20


<210>  11051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11051
auccccccag ugacccccag                                                   20


<210>  11052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11052
agugacuuca uccuccaucc                                                   20


<210>  11053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11053
ucuccaguga cuucauccuc                                                   20


<210>  11054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11054
agccacugcc agcccauguc                                                   20


<210>  11055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11055
ccagccacug ccagcccaug                                                   20


<210>  11056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11056
ucuccagcca cugccagccc                                                   20


<210>  11057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11057
uccuggagcc aggggucagc                                                   20


<210>  11058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11058
aggacgagcc uguagcaccc                                                   20


<210>  11059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11059
aggcugaccc cuggcuccag                                                   20


<210>  11060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11060
cggcuaccuc acucugcuua                                                   20


<210>  11061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11061
cucugcuuag agcugacugu                                                   20


<210>  11062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11062
gcuuagagcu gacuguuaaa                                                   20


<210>  11063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11063
aagcagagug agguagccgg                                                   20


<210>  11064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11064
auuauuuaac agucagcucu                                                   20


<210>  11065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11065
cacaggacac ugacagggcu                                                   20


<210>  11066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11066
auuucuggua cauauuuaua                                                   20


<210>  11067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11067
uaggggcaga cuccauuucu                                                   20


<210>  11068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11068
caguuuaaug uuaggccuaa                                                   20


<210>  11069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11069
ugcuauaauc ccagcacuuu                                                   20


<210>  11070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11070
caaagugcug ggauuauagc                                                   20


<210>  11071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11071
ugauccaccu gccuugaccu                                                   20


<210>  11072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11072
ugaccucaug auccaccugc                                                   20


<210>  11073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11073
aacuccugac cucaugaucc                                                   20


<210>  11074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11074
acuaaaaaaa aaauuagcca                                                   20


<210>  11075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11075
gaaggcugug ccacugcacu                                                   20


<210>  11076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11076
agccuggcga cagagcauga                                                   20


<210>  11077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11077
gucgccaggc uggagugcag                                                   20


<210>  11078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11078
gucucaaaaa agaaaaaaga                                                   20


<210>  11079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11079
aaaaagaaaa aagaaaagaa                                                   20


<210>  11080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11080
gggaggggaa gaaaaauaaa                                                   20


<210>  11081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11081
ccgagccuag cagaacaagu                                                   20


<210>  11082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11082
ggggcuuuca agaugaaauc                                                   20


<210>  11083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11083
aacaccacgg auuucaucuu                                                   20


<210>  11084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11084
uuucccagca ccuccaacac                                                   20


<210>  11085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11085
gacaccuccu uucccagcac                                                   20


<210>  11086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11086
cucagacacc uccuuuccca                                                   20


<210>  11087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11087
gugugagaag cucuagcuuu                                                   20


<210>  11088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11088
cacagagccc ucacucagac                                                   20


<210>  11089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11089
agcuuugaag uuagggccag                                                   20


<210>  11090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11090
ccuggcccua acuucaaagc                                                   20


<210>  11091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11091
gcucccauua caggaucauc                                                   20


<210>  11092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11092
cauuacagga ucaucucucc                                                   20


<210>  11093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11093
cccagcucag uuucucauuu                                                   20


<210>  11094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11094
cagcucaguu ucucauuuau                                                   20


<210>  11095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11095
guuucucauu uaugaaaugu                                                   20


<210>  11096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11096
uuuaugaaau guagaugaga                                                   20


<210>  11097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11097
ucuacauuuc auaaaugaga                                                   20


<210>  11098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11098
caucuacauu ucauaaauga                                                   20


<210>  11099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11099
uacuuuauag gauuguuggg                                                   20


<210>  11100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11100
caacaauccu auaaaguaag                                                   20


<210>  11101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11101
auaauuacua agaggagaaa                                                   20


<210>  11102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11102
uaguaauuau ggaggauuau                                                   20


<210>  11103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11103
ucuuaguaau uauggaggau                                                   20


<210>  11104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11104
gguccagcug ccagcaguug                                                   20


<210>  11105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11105
ccucugcucu gugcugccug                                                   20


<210>  11106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11106
ucugcucugu gcugccuggu                                                   20


<210>  11107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11107
gcucugugcu gccuggucag                                                   20


<210>  11108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11108
gugcugccug gucaggccau                                                   20


<210>  11109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11109
gucuaaggga uucugucaua                                                   20


<210>  11110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11110
gucaggaggc uggaaguccu                                                   20


<210>  11111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11111
ugacugagaa aauaaacuuc                                                   20


<210>  11112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11112
ccaacaccaa aucugcaggc                                                   20


<210>  11113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11113
cugcuucaaa gauggagccu                                                   20


<210>  11114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11114
gcuucaaaga uggagccuug                                                   20


<210>  11115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11115
aucuuugaag cagagagcag                                                   20


<210>  11116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11116
agccaaggcu ccaucuuuga                                                   20


<210>  11117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11117
uaccuauaau cuuagcacuu                                                   20


<210>  11118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11118
caaagugcua agauuauagg                                                   20


<210>  11119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11119
gccucccaaa gugcuaagau                                                   20


<210>  11120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11120
caccucagcc ucccaaagug                                                   20


<210>  11121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11121
agugauccuc ccaccucagc                                                   20


<210>  11122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11122
uuggcucaag ugauccuccc                                                   20


<210>  11123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11123
agcuccuugg cucaagugau                                                   20


<210>  11124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11124
cuguguuacc caggcugguc                                                   20


<210>  11125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11125
aucuuucuuu cuuuucuuuu                                                   20


<210>  11126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11126
cugcacccuc acagggcaga                                                   20


<210>  11127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11127
cagggcagag gacaaaccag                                                   20


<210>  11128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11128
gcccugugag ggugcaguga                                                   20


<210>  11129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11129
cuggggcccc uuuucuaaug                                                   20


<210>  11130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11130
ugaaugggau uccugccauu                                                   20


<210>  11131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11131
gcccucguga augggauucc                                                   20


<210>  11132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11132
ucaccuccag aaggucccac                                                   20


<210>  11133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11133
agaagguccc accucucaau                                                   20


<210>  11134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11134
caauacuauu gcauugggga                                                   20


<210>  11135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11135
auacuauugc auuggggauu                                                   20


<210>  11136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11136
gaaugugugu aucccccaca                                                   20


<210>  11137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11137
augggagugg aguaugcugg                                                   20


<210>  11138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11138
caucgagggc caggaugcuc                                                   20


<210>  11139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11139
acucccaucg agggccagga                                                   20


<210>  11140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11140
accauggggc uguggagucc                                                   20


<210>  11141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11141
acagccccau gguugagcuu                                                   20


<210>  11142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11142
gggacuccac agccccaugg                                                   20


<210>  11143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11143
aagaaacaac aacaaauaaa                                                   20


<210>  11144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11144
gucucaaaga aacaacaaca                                                   20


<210>  11145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11145
agaaacagau cuggcccagg                                                   20


<210>  11146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11146
aaccugggcc agaucuguuu                                                   20


<210>  11147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11147
gcucacugca gcaucugccu                                                   20


<210>  11148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11148
cugcagcauc ugccucccgg                                                   20


<210>  11149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11149
cggguucaag ggauucuccu                                                   20


<210>  11150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11150
ugccucaggc uccugaguag                                                   20


<210>  11151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11151
ggcuccugag uagcugggac                                                   20


<210>  11152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11152
ugaguagcug ggacuacagg                                                   20


<210>  11153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11153
ggagccugag gcaggagaau                                                   20


<210>  11154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11154
acuaaaaaua caaaaauuag                                                   20


<210>  11155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11155
ugaccucgug auccacccac                                                   20


<210>  11156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11156
ugauccaccc accucggccu                                                   20


<210>  11157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11157
gccucccaaa augcugggau                                                   20


<210>  11158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11158
caaaaugcug ggauuacggg                                                   20


<210>  11159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11159
ugcccguaau cccagcauuu                                                   20


<210>  11160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11160
augcguuuau ucuuugcaug                                                   20


<210>  11161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11161
guaacaguug cucaaugcgu                                                   20


<210>  11162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11162
ggcuaggugc ugggguauca                                                   20


<210>  11163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11163
ggcccacugu gauaccccag                                                   20


<210>  11164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11164
aagcuuccug aagcuaaggc                                                   20


<210>  11165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11165
uucucagcaa gaaauacuug                                                   20


<210>  11166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11166
gcaagaaaua cuugucaucg                                                   20


<210>  11167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11167
augacaagua uuucuugcug                                                   20


<210>  11168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11168
ucgaugacaa guauuucuug                                                   20


<210>  11169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11169
ccucgaugac aaguauuucu                                                   20


<210>  11170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11170
accucuccuc gaugacaagu                                                   20


<210>  11171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11171
ggcuguggca aaaaaauuug                                                   20


<210>  11172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11172
ccaaauuuuu uugccacagc                                                   20


<210>  11173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11173
ugcuaaauuc uucagguuuu                                                   20


<210>  11174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11174
ucggcuugcu gacuccugcu                                                   20


<210>  11175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11175
agggcugugu cuacaaagcu                                                   20


<210>  11176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11176
uugcugggcu gugccugcuc                                                   20


<210>  11177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11177
gcuccuugcu gggcugugcc                                                   20


<210>  11178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11178
cagcuccuug cugggcugug                                                   20


<210>  11179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11179
caccgcucuc agcuccuugc                                                   20


<210>  11180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11180
aagucccaaa gaccagaaag                                                   20


<210>  11181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11181
gccgcuauag uggaaaaggg                                                   20


<210>  11182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11182
aaagcaacac augaaagacc                                                   20


<210>  11183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11183
ucaaucagaa aaagcagggc                                                   20


<210>  11184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11184
gcaauucuca ucaaucagaa                                                   20


<210>  11185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11185
cauacauauu uaccaucauc                                                   20


<210>  11186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11186
uuagaaagua uuccucacau                                                   20


<210>  11187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11187
aaauaucuuc uuaauauuuu                                                   20


<210>  11188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11188
uucucaaaau aucuucuuaa                                                   20


<210>  11189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11189
ucugaggucc uuagugguau                                                   20


<210>  11190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11190
gaugaggcaa ccacuuagca                                                   20


<210>  11191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11191
uuaaaaaucc ccacauuuuu                                                   20


<210>  11192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11192
aaggcgaaac cuucgccccc                                                   20


<210>  11193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11193
uuugugaagu gucauauaau                                                   20


<210>  11194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11194
uuaaauuaua ugacacuuca                                                   20


<210>  11195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11195
gacuuuacuc auuaaauuau                                                   20


<210>  11196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11196
ggaacucaga cuuuacucau                                                   20


<210>  11197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11197
cgacuguaau cccagcacuu                                                   20


<210>  11198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11198
caaagugcug ggauuacagu                                                   20


<210>  11199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11199
accucccaaa gugcugggau                                                   20


<210>  11200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11200
ugauccaccc gccucgaccu                                                   20


<210>  11201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11201
ugaccucgug auccacccgc                                                   20


<210>  11202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11202
aucuccugac cucgugaucc                                                   20


<210>  11203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11203
acuaaaaaua caaaaaauua                                                   20


<210>  11204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11204
ggaggcugag gcaggagaau                                                   20


<210>  11205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11205
cgaguagcug ggacuauggg                                                   20


<210>  11206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11206
gccucccgag uagcugggac                                                   20


<210>  11207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11207
ugccucagcc ucccgaguag                                                   20


<210>  11208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11208
cggguucacg ccauucuccu                                                   20


<210>  11209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11209
gccucccggg uucacgccau                                                   20


<210>  11210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11210
cugcaagcuc agccucccgg                                                   20


<210>  11211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11211
gcucacugca agcucagccu                                                   20


<210>  11212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11212
agccugggug acagaacgag                                                   20


<210>  11213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11213
uucugucacc caggcuggag                                                   20


<210>  11214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11214
aucucaaaaa aagaaaaaaa                                                   20


<210>  11215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11215
aaaaaagaaa aaaaaagaaa                                                   20


<210>  11216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11216
gcccucccga guccuuuggu                                                   20


<210>  11217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11217
cgaguccuuu gguuauuauu                                                   20


<210>  11218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11218
ggagggcaga gcaggugcau                                                   20


<210>  11219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11219
ccugcauaau aauaaccaaa                                                   20


<210>  11220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11220
aaacuccccu gcauaauaau                                                   20


<210>  11221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11221
ggauaaaaau gaaaacucaa                                                   20


<210>  11222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11222
aguggguugc auuucugccu                                                   20


<210>  11223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11223
ugcaguuacu caccaagaau                                                   20


<210>  11224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11224
ccaagaaucc aagcaagcgg                                                   20


<210>  11225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11225
ccccugcagc ccagccgcuu                                                   20


<210>  11226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11226
cucgccccug cagcccagcc                                                   20


<210>  11227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11227
ugaaguugau guccuugaac                                                   20


<210>  11228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11228
agccuccuga aguugauguc                                                   20


<210>  11229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11229
agcauguuug ccuccagccu                                                   20


<210>  11230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11230
uccuggcaau gcacuuacau                                                   20


<210>  11231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11231
uucuuuuuuc aaaaauagag                                                   20


<210>  11232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11232
auuuuugaaa aaagaaagag                                                   20


<210>  11233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11233
cuguguugcc caggcugguc                                                   20


<210>  11234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11234
uggccucaag ugguccucca                                                   20


<210>  11235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11235
agugguccuc caccuuggcc                                                   20


<210>  11236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11236
accuuggccu cccacagugc                                                   20


<210>  11237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11237
cacagugcug ggauuauagg                                                   20


<210>  11238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11238
cgccuauaau cccagcacug                                                   20


<210>  11239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11239
uggugccugu ccuaccuggu                                                   20


<210>  11240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11240
cccgucaccc cagugugcuu                                                   20


<210>  11241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11241
cugggccccu cacagaccuc                                                   20


<210>  11242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11242
cagaccucag cggugcucua                                                   20


<210>  11243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11243
gcggugcucu agcucccugc                                                   20


<210>  11244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11244
agcucccugc cucgugucac                                                   20


<210>  11245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11245
cugccucgug ucacugucag                                                   20


<210>  11246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11246
ugucacuguc agccucacug                                                   20


<210>  11247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11247
cugcuggggg agccccccag                                                   20


<210>  11248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11248
cccagcagug aggcugacag                                                   20


<210>  11249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11249
gcuaccuggg gggcuccccc                                                   20


<210>  11250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11250
uuuucacuuc uuuucuagag                                                   20


<210>  11251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11251
agaaaagaag ugaaaaugag                                                   20


<210>  11252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11252
cuauguugcc caggcuacuu                                                   20


<210>  11253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11253
uggccccaag ugauccuccu                                                   20


<210>  11254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11254
ugccuugacc ucccagaaug                                                   20


<210>  11255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11255
cagaaugcug ggauuacagg                                                   20


<210>  11256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11256
ugccuguaau cccagcauuc                                                   20


<210>  11257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11257
gggcuggcuu ucucucucau                                                   20


<210>  11258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11258
cucauucuug uguuucccac                                                   20


<210>  11259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11259
cauucuugug uuucccacag                                                   20


<210>  11260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11260
uucuuguguu ucccacagcc                                                   20


<210>  11261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11261
cggcuguggg aaacacaaga                                                   20


<210>  11262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11262
gcuucucaug agguccuggg                                                   20


<210>  11263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11263
ugagguccug ggacuguggc                                                   20


<210>  11264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11264
ugagaagcag aguggggaca                                                   20


<210>  11265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11265
guacggggcc aggccacagu                                                   20


<210>  11266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11266
uugugagugu gcuguuggga                                                   20


<210>  11267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11267
caaggaggca cagugaccac                                                   20


<210>  11268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11268
ggacuguccc cgaggggcgg                                                   20


<210>  11269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11269
gggacagucc agaggaaggu                                                   20


<210>  11270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11270
ccaccuugag gguaugaaug                                                   20


<210>  11271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11271
agguggggag gcggaagugg                                                   20


<210>  11272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11272
uucauacccu caaggugggg                                                   20


<210>  11273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11273
ucacucauuc auacccucaa                                                   20


<210>  11274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11274
aacagcugug cugaccgugg                                                   20


<210>  11275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11275
aaaggccacg gucagcacag                                                   20


<210>  11276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11276
cuguagugca caaguccugg                                                   20


<210>  11277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11277
ggacugcggg ugccuccggc                                                   20


<210>  11278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11278
ggcaugagca gaugaggguc                                                   20


<210>  11279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11279
ugccggaggc acccgcaguc                                                   20


<210>  11280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11280
ucugcucaug ccggaggcac                                                   20


<210>  11281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11281
accugccgcc aguacaguuc                                                   20


<210>  11282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11282
cuccugccug ccugacccuc                                                   20


<210>  11283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11283
ugccugccug acccucugcc                                                   20


<210>  11284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11284
gccucugagg acagcagugc                                                   20


<210>  11285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11285
gaggacagca gugccgggau                                                   20


<210>  11286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11286
gaggcagagg gucaggcagg                                                   20


<210>  11287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11287
uaucccggca cugcuguccu                                                   20


<210>  11288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11288
gggacaggaa cccaggucug                                                   20


<210>  11289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11289
ucugggacag gaacccaggu                                                   20


<210>  11290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11290
cugaaucagc aggucccucc                                                   20


<210>  11291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11291
gcucccugaa ucagcagguc                                                   20


<210>  11292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11292
gcucagcucc cugaaucagc                                                   20


<210>  11293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11293
ucccuccgcu cagcucccug                                                   20


<210>  11294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11294
aaggcugcaa gggaccucau                                                   20


<210>  11295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11295
guggaccugc aggaggaugg                                                   20


<210>  11296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11296
ugcaggucca cugagugguc                                                   20


<210>  11297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11297
cacuucccau ccuccugcag                                                   20


<210>  11298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11298
gguuuucucc gggugcuuug                                                   20


<210>  11299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11299
gggugcuuug ccaggagugc                                                   20


<210>  11300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11300
uggcaaagca cccggagaaa                                                   20


<210>  11301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11301
aauucuuggu gcacuccugg                                                   20


<210>  11302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11302
ccccugccuc caauucuugg                                                   20


<210>  11303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11303
gucccuguuc acacuucucc                                                   20


<210>  11304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11304
gguucugugc ugcaucuucc                                                   20


<210>  11305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11305
guuugcaauc cauuuugcac                                                   20


<210>  11306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11306
uuuccguagu gcaaaaugga                                                   20


<210>  11307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11307
ggaggggugu gugugugugu                                                   20


<210>  11308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11308
ugaggccaug cccuucuccu                                                   20


<210>  11309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11309
cacacacaca cacacacaua                                                   20


<210>  11310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11310
uucucacaca cacacacaca                                                   20


<210>  11311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11311
cucuuucuca cacacacaca                                                   20


<210>  11312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11312
cccucuuucu cacacacaca                                                   20


<210>  11313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11313
cucccucuuu cucacacaca                                                   20


<210>  11314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11314
ucagaggaca cauucuguga                                                   20


<210>  11315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11315
gaagaggugg uucgccagcu                                                   20


<210>  11316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11316
agugagaggg gccuggcaaa                                                   20


<210>  11317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11317
cuugaggcau uuucuaaauc                                                   20


<210>  11318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11318
cacuugaggc auuuucuaaa                                                   20


<210>  11319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11319
auucuuuugc caggccccuc                                                   20


<210>  11320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11320
cugucuccau ucuuuugcca                                                   20


<210>  11321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11321
cccugucucc auucuuuugc                                                   20


<210>  11322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11322
guucccaaga augaaacgcc                                                   20


<210>  11323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11323
cucaguuccc aagaaugaaa                                                   20


<210>  11324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11324
gcucccucag uucccaagaa                                                   20


<210>  11325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11325
gaggcugccc cuguucuugc                                                   20


<210>  11326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11326
gagaugacua cagcaauucu                                                   20


<210>  11327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11327
ugccguuuac uguaaggacg                                                   20


<210>  11328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11328
auauccagga cguccuuaca                                                   20


<210>  11329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11329
guggugaaag ggaucuaccu                                                   20


<210>  11330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11330
guuugcuacc gggugugucu                                                   20


<210>  11331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11331
auccccuggc agaaugaggu                                                   20


<210>  11332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11332
uucugccagg ggauggagac                                                   20


<210>  11333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11333
caaauacaca cagacacaca                                                   20


<210>  11334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11334
cgccuguaau cccagcacuu                                                   20


<210>  11335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11335
caaagugcug ggauuacagg                                                   20


<210>  11336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11336
gccucccaaa gugcugggau                                                   20


<210>  11337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11337
ugaucugccu gccucagccu                                                   20


<210>  11338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11338
ugaccucaug aucugccugc                                                   20


<210>  11339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11339
aacuccugac cucaugaucu                                                   20


<210>  11340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11340
acuaaaagua caaaaauuag                                                   20


<210>  11341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11341
gcaucccuac uagcugggac                                                   20


<210>  11342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11342
ugccucagca ucccuacuag                                                   20


<210>  11343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11343
cagguucaag cgauucuccu                                                   20


<210>  11344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11344
cugcaacuuc ugccucccag                                                   20


<210>  11345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11345
gcucacugca acuucugccu                                                   20


<210>  11346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11346
accuugggcg acagaacgag                                                   20


<210>  11347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11347
uucugucgcc caagguggag                                                   20


<210>  11348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11348
cccaaaaaaa aaaaaaaaaa                                                   20


<210>  11349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11349
uguccacuuc cugucauugg                                                   20


<210>  11350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11350
caucagaccc aaaauagcua                                                   20


<210>  11351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11351
ggguggcagg caagcuccca                                                   20


<210>  11352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11352
cuaagcaggg cuggcuggca                                                   20


<210>  11353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11353
caaagcaggg aacuaccaug                                                   20


<210>  11354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11354
gagacaaggg gagaggagac                                                   20


<210>  11355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11355
gaguguacuc ccaaagcagg                                                   20


<210>  11356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11356
ccuugucucu gaguguacuc                                                   20


<210>  11357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11357
ccccuugucu cugaguguac                                                   20


<210>  11358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11358
ucuccccuug ucucugagug                                                   20


<210>  11359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11359
ucuuggaaua aguaaugugg                                                   20


<210>  11360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11360
uucccugcuu ccugaccucu                                                   20


<210>  11361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11361
ugcacccacu guggggcccc                                                   20


<210>  11362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11362
gaggugcccc gcacggggcu                                                   20


<210>  11363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11363
gagcuccugc acccacugug                                                   20


<210>  11364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11364
ugcccagccc cgugcggggc                                                   20


<210>  11365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11365
cagugccagc agcuccugcc                                                   20


<210>  11366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11366
gcggcuucuc uguccuguua                                                   20


<210>  11367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11367
guccuguuau ucugugcaug                                                   20


<210>  11368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11368
cuuucacuuu uguugauguc                                                   20


<210>  11369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11369
guuuggucug gaaaccgggg                                                   20


<210>  11370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11370
ucagaagagg gguaaaaaga                                                   20


<210>  11371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11371
ucugaagagu cuauagaaga                                                   20


<210>  11372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11372
uacaggcagu uuuauacagu                                                   20


<210>  11373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11373
gacuguauaa aacugccugu                                                   20


<210>  11374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11374
cagacuguau aaaacugccu                                                   20


<210>  11375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11375
accuagcacc auguggcucu                                                   20


<210>  11376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11376
uuguucuggc uggccuccac                                                   20


<210>  11377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11377
cagugagguu uguugcuggg                                                   20


<210>  11378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11378
cugcgagggu guucucauug                                                   20


<210>  11379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11379
gaaaucggca uccuguggaa                                                   20


<210>  11380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11380
cagugcaucu cucccugcuc                                                   20


<210>  11381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11381
cccugcucug gcucuuagac                                                   20


<210>  11382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11382
cugcucuggc ucuuagacuc                                                   20


<210>  11383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11383
ggcucuuaga cucaccuccu                                                   20


<210>  11384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11384
uagacucacc uccuucgccc                                                   20


<210>  11385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11385
ccuccuucgc ccgcugcacg                                                   20


<210>  11386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11386
uucgcccgcu gcacggggaa                                                   20


<210>  11387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11387
cgccuguaau cccagcacuu                                                   20


<210>  11388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11388
caaagugcug ggauuacagg                                                   20


<210>  11389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11389
gccucccaaa gugcugggau                                                   20


<210>  11390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11390
ggugauccac cugccucggc                                                   20


<210>  11391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11391
ugaccucagg ugauccaccu                                                   20


<210>  11392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11392
aacuccugac cucaggugau                                                   20


<210>  11393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11393
caaguagcug ggacuacagg                                                   20


<210>  11394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11394
gccucccaag uagcugggac                                                   20


<210>  11395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11395
ugccucagcc ucccaaguag                                                   20


<210>  11396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11396
uggguucacg cgauucuccu                                                   20


<210>  11397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11397
accuccuggg uucacgcgau                                                   20


<210>  11398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11398
cugcacccuc caccuccugg                                                   20


<210>  11399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11399
gcucacugca cccuccaccu                                                   20


<210>  11400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11400
agccugggca acagcgcaag                                                   20


<210>  11401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11401
aucucaaaaa gaaagaaaga                                                   20


<210>  11402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11402
aaaagaaaga aagaaaaaug                                                   20


<210>  11403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11403
ccuuggauuc gugggccauc                                                   20


<210>  11404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11404
uuggauucgu gggccauccu                                                   20


<210>  11405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11405
gaaucaaccc ccugggaaca                                                   20


<210>  11406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11406
cgccuguaau cccagcacuu                                                   20


<210>  11407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11407
caaagugcug ggauuacagg                                                   20


<210>  11408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11408
gccucccaaa gugcugggau                                                   20


<210>  11409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11409
ucagccuccc aaagugcugg                                                   20


<210>  11410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11410
ggugauccac ccuccucagc                                                   20


<210>  11411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11411
ugaccucagg ugauccaccc                                                   20


<210>  11412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11412
acuaaaaaua uaaaaauuag                                                   20


<210>  11413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11413
cagguagcug ggauuacagg                                                   20


<210>  11414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11414
gacucccagg uagcugggau                                                   20


<210>  11415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11415
ugccucagac ucccagguag                                                   20


<210>  11416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11416
cagguucaag cgauucuccu                                                   20


<210>  11417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11417
gccucccagg uucaagcgau                                                   20


<210>  11418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11418
cuguaaccuc cgccucccag                                                   20


<210>  11419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11419
gcucccugua accuccgccu                                                   20


<210>  11420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11420
agccugggug acaagaguga                                                   20


<210>  11421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11421
ugucacccag gcuggagcgc                                                   20


<210>  11422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11422
gucuuaaaaa aaaaaaaaaa                                                   20


<210>  11423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11423
aaguggcauu ucccauggcu                                                   20


<210>  11424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11424
gagaacuaag gguuaggugu                                                   20


<210>  11425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11425
gaggaaagac agccauggga                                                   20


<210>  11426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11426
cccugacccu caguguguag                                                   20


<210>  11427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11427
cugacccuca guguguagcc                                                   20


<210>  11428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11428
guguguagcc agcccugcau                                                   20


<210>  11429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11429
ucccugggcc ccggucccag                                                   20


<210>  11430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11430
cugggccccg gucccagugu                                                   20


<210>  11431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11431
aaguguggac acugggaccg                                                   20


<210>  11432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11432
acggcagguu uuccccaaaa                                                   20


<210>  11433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11433
caacggcagg uuuuccccaa                                                   20


<210>  11434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11434
gugcaaucag auucucucaa                                                   20


<210>  11435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11435
ccacacugcu ucuuaggcag                                                   20


<210>  11436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11436
ggcugccuaa gaagcagugu                                                   20


<210>  11437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11437
gccaugguac augcagaacu                                                   20


<210>  11438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11438
cauacauagg aaaugcagca                                                   20


<210>  11439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11439
uuauuuacuu caugaugugg                                                   20


<210>  11440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11440
caccuguaau cucagcacuu                                                   20


<210>  11441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11441
gcacuuuggg aggcugaggu                                                   20


<210>  11442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11442
caaagugcug agauuacagg                                                   20


<210>  11443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11443
gccucccaaa gugcugagau                                                   20


<210>  11444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11444
caccucagcc ucccaaagug                                                   20


<210>  11445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11445
agugauccuc ccaccucagc                                                   20


<210>  11446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11446
ugaucucaag ugauccuccc                                                   20


<210>  11447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11447
aacuccugau cucaagugau                                                   20


<210>  11448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11448
cgaacuccug aucucaagug                                                   20


<210>  11449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11449
gcuaaaaaua caaaacuuag                                                   20


<210>  11450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11450
ggaggcugag gaaggagaau                                                   20


<210>  11451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11451
ugaguagcua ggaccacagc                                                   20


<210>  11452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11452
gccuccugag uagcuaggac                                                   20


<210>  11453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11453
uuccucagcc uccugaguag                                                   20


<210>  11454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11454
accuuccagg uucaagcaau                                                   20


<210>  11455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11455
gaucacuaca accuccaccu                                                   20


<210>  11456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11456
agccugggcg acagagugag                                                   20


<210>  11457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11457
gucgcccagg cuggagugca                                                   20


<210>  11458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11458
cucugucgcc caggcuggag                                                   20


<210>  11459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11459
aaaaauaaau aaauaaauaa                                                   20


<210>  11460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11460
ggcacacggc ugaugcgaag                                                   20


<210>  11461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11461
cuggggacca uggucaggca                                                   20


<210>  11462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11462
gcauugcuug gguuccacuu                                                   20


<210>  11463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11463
gugguccgca ccggggugcu                                                   20


<210>  11464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11464
uuccuggcgc cagggucugc                                                   20


<210>  11465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11465
ucccaccugg aauuguaaua                                                   20


<210>  11466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11466
caaggcaugu uuuauuuaga                                                   20


<210>  11467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11467
gguauuagug cagaaagguc                                                   20


<210>  11468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11468
uggggcuuuu ucuucaaucc                                                   20


<210>  11469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11469
gggguacucu uggggcuuuu                                                   20


<210>  11470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11470
cacccuagca ugcaaggcgc                                                   20


<210>  11471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11471
cugggugcag ggaaagcucc                                                   20


<210>  11472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11472
cccugggugc agggaaagcu                                                   20


<210>  11473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11473
cgccaccccc agacuugguc                                                   20


<210>  11474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11474
ccacucggcc agagaugugg                                                   20


<210>  11475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11475
gccagagaug ugguggucca                                                   20


<210>  11476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11476
ggccgagugg ugagaccaag                                                   20


<210>  11477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11477
uccuggacca ccacaucucu                                                   20


<210>  11478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11478
cuuccuggac caccacaucu                                                   20


<210>  11479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11479
cuuuccccag ggcccgggug                                                   20


<210>  11480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11480
gacugucuga cacccgggcc                                                   20


<210>  11481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11481
cgauggcugu cccguugccu                                                   20


<210>  11482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11482
ccgagauucc uucgguuugu                                                   20


<210>  11483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11483
gugaggggca caaggcaacg                                                   20


<210>  11484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11484
gagcauaucu aucugcccuu                                                   20


<210>  11485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11485
gagaaaauga aaacuggcca                                                   20


<210>  11486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11486
ccaugacccu gcagucaggg                                                   20


<210>  11487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11487
agcaggugcg cccggcaugc                                                   20


<210>  11488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11488
cacggugcag gcugucaccg                                                   20


<210>  11489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11489
ggggcccuga cguggacucc                                                   20


<210>  11490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11490
cgggggcccu gacguggacu                                                   20


<210>  11491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11491
ucccugacac aguaccggcc                                                   20


<210>  11492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11492
ucaucccuga cacaguaccg                                                   20


<210>  11493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11493
ugggcuuuag uggcgcuuag                                                   20


<210>  11494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11494
uaagcgccac uaaagcccag                                                   20


<210>  11495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11495
caggcuccua agcgccacua                                                   20


<210>  11496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11496
acgggaagcu cccaggcucc                                                   20


<210>  11497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11497
gcuugugcag uuucagcgcc                                                   20


<210>  11498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11498
cagcuugugc aguuucagcg                                                   20


<210>  11499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11499
cagcagugcg uggugccucu                                                   20


<210>  11500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11500
ucagcugggg ugcucacccg                                                   20


<210>  11501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11501
cccgcgggga gacguggcuu                                                   20


<210>  11502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11502
ccgcggguga gcaccccagc                                                   20


<210>  11503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11503
gcgggcuuca gugccggucc                                                   20


<210>  11504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11504
aacgucgccc ccugggaaau                                                   20


<210>  11505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11505
ccgcccagcu ccaacgucgc                                                   20


<210>  11506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11506
uguucgcucc ccgcccagcu                                                   20


<210>  11507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11507
cugucccucc uguucgcucc                                                   20


<210>  11508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11508
gcccucccug ucccuccugu                                                   20


<210>  11509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11509
ggggccucag cccucccugu                                                   20


<210>  11510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11510
gcagggucag cucuggggcc                                                   20


<210>  11511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11511
cuggcggccu ugaagcugcg                                                   20


<210>  11512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11512
aaggaucugg gcgcagcuuc                                                   20


<210>  11513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11513
ccaugucaag ugcugcccug                                                   20


<210>  11514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11514
cugaaccagc ccucaccaug                                                   20


<210>  11515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11515
ucccugaacc agcccucacc                                                   20


<210>  11516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11516
gccccaucca uucuccacug                                                   20


<210>  11517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11517
acugcuguca gggcugccug                                                   20


<210>  11518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11518
aggcagcccu gacagcagug                                                   20


<210>  11519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11519
gugcugccug cugcgugaga                                                   20


<210>  11520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11520
cgcagcaggc agcacagaga                                                   20


<210>  11521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11521
gugacuuuga accagacagu                                                   20


<210>  11522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11522
cgcgcgcagc uguccgaugu                                                   20


<210>  11523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11523
cccgcgcgca gcuguccgau                                                   20


<210>  11524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11524
ggcacugugg uuccucuccc                                                   20


<210>  11525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11525
cugggccgcu uucacaagag                                                   20


<210>  11526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11526
ugugaaagcg gcccagggag                                                   20


<210>  11527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11527
ugcugcucuu gugaaagcgg                                                   20


<210>  11528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11528
agcaggggca cuggggcccg                                                   20


<210>  11529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11529
caggacgggc cccagugccc                                                   20


<210>  11530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11530
uggugacauc cccgcuggug                                                   20


<210>  11531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11531
caaccucaug gugacauccc                                                   20


<210>  11532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11532
uacaaagaag gcucccaacc                                                   20


<210>  11533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11533
aagauaacgu ccccuucccc                                                   20


<210>  11534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11534
aucagaagaa aagcaaagcu                                                   20


<210>  11535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11535
uuaaagagua aggcuuuuug                                                   20


<210>  11536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11536
uuaaugaguu uugccucaau                                                   20


<210>  11537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11537
ggaccccucu ccucugugcc                                                   20


<210>  11538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11538
ccucugugcc ucacuguccu                                                   20


<210>  11539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11539
ucugugccuc acuguccuca                                                   20


<210>  11540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11540
gugccucacu guccucagcu                                                   20


<210>  11541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11541
cuguccucag cugcagaaug                                                   20


<210>  11542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11542
gcugcagaau gaagauggca                                                   20


<210>  11543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11543
ugccaucuuc auucugcagc                                                   20


<210>  11544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11544
gcaucccggg ggcaccaacu                                                   20


<210>  11545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11545
cagcaucccg ggggcaccaa                                                   20


<210>  11546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11546
gaaaccugcu cucagcaucc                                                   20


<210>  11547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11547
uugcagaaaa uacaggaaaa                                                   20


<210>  11548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11548
gacucuuucc aggaguucuu                                                   20


<210>  11549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11549
uuccaggagu ucuuccauca                                                   20


<210>  11550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11550
uggaaagagu cagaguggaa                                                   20


<210>  11551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11551
gcugggggcu ggggaccugg                                                   20


<210>  11552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11552
gcccagccag guccccagcc                                                   20


<210>  11553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11553
guaaaggccu gccucgcgca                                                   20


<210>  11554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11554
cgcagguguu gaaguuuagg                                                   20


<210>  11555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11555
gacaggcagg ugucccuaaa                                                   20


<210>  11556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11556
uguucaaaug ccucugacag                                                   20


<210>  11557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11557
aucuugaaug ggggcugggu                                                   20


<210>  11558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11558
uuuuacccag cccccauuca                                                   20


<210>  11559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11559
ggcucauuuu acccagcccc                                                   20


<210>  11560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11560
ugggaaugcg gcccagcagg                                                   20


<210>  11561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11561
uccuguaacu aagaaugccu                                                   20


<210>  11562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11562
uaucucaucc uguaacuaag                                                   20


<210>  11563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11563
uugggaccug uauuuugugc                                                   20


<210>  11564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11564
ggcuucuuua aaacagucug                                                   20


<210>  11565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11565
ugccuguaau cccagcacuu                                                   20


<210>  11566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11566
caaagugcug ggauuacagg                                                   20


<210>  11567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11567
gccucccaaa gugcugggau                                                   20


<210>  11568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11568
agugauccac cugccucggc                                                   20


<210>  11569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11569
uggccucaag ugauccaccu                                                   20


<210>  11570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11570
aacuccuggc cucaagugau                                                   20


<210>  11571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11571
aauacaaaaa uuagccaggu                                                   20


<210>  11572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11572
ggaggcugag gcaggagaau                                                   20


<210>  11573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11573
cgaguagcug ggaccacagg                                                   20


<210>  11574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11574
gccucccgag uagcugggac                                                   20


<210>  11575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11575
ugccucagcc ucccgaguag                                                   20


<210>  11576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11576
ugaacccagg agucagaggc                                                   20


<210>  11577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11577
uggguucaag agauucuccu                                                   20


<210>  11578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11578
gacuccuggg uucaagagau                                                   20


<210>  11579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11579
cugcagccuc ugacuccugg                                                   20


<210>  11580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11580
gcucacugca gccucugacu                                                   20


<210>  11581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11581
guugcccagg ucucggcuca                                                   20


<210>  11582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11582
aaaaaaauaa uaaaauaaag                                                   20


<210>  11583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11583
ucgccaucuu gguuuuggug                                                   20


<210>  11584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11584
caucgccauc uugguuuugg                                                   20


<210>  11585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11585
ggucauccuc acagcucauu                                                   20


<210>  11586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11586
cagcucauua caugcuaauu                                                   20


<210>  11587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11587
uuacaugcua auuauaaugc                                                   20


<210>  11588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11588
caucagcgcc augacaguuu                                                   20


<210>  11589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11589
uuuuagaaca uacaggguag                                                   20


<210>  11590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11590
ucuuuuuaga acauacaggg                                                   20


<210>  11591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11591
caguucuggg aaucgcccac                                                   20


<210>  11592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11592
guucugggaa ucgcccaccc                                                   20


<210>  11593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11593
ugaauaaucc accccuuguu                                                   20


<210>  11594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11594
aggcugcucu gccuacggag                                                   20


<210>  11595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11595
gccuacggag uagccauucu                                                   20


<210>  11596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11596
guaggcagag cagccuagag                                                   20


<210>  11597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11597
aauuguuucc ugagcgagau                                                   20


<210>  11598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11598
ggaaacaauu cgaggcuaau                                                   20


<210>  11599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11599
cucaggaaac aauucgaggc                                                   20


<210>  11600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11600
uuuggggucu ggaucgggac                                                   20


<210>  11601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11601
cuccaucuug ccugcugagg                                                   20


<210>  11602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11602
aucuugccug cugaggagga                                                   20


<210>  11603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11603
gcaggcaaga uggagggagu                                                   20


<210>  11604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11604
ucagcaggca agauggaggg                                                   20


<210>  11605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11605
ggcccugggc ccugcaaccc                                                   20


<210>  11606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11606
gacuagcuua agcaaaaaaa                                                   20


<210>  11607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11607
gucaaagcuu ucacuugggc                                                   20


<210>  11608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11608
cagucaaagc uuucacuugg                                                   20


<210>  11609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11609
uuuuucucuu ucuguuuaua                                                   20


<210>  11610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11610
uucuguuuau aagcaagcau                                                   20


<210>  11611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11611
ucaauacaua caugcuugcu                                                   20


<210>  11612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11612
cuguggcagc auauacacua                                                   20


<210>  11613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11613
guaucauucc aguuuuagug                                                   20


<210>  11614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11614
ucuuuaauau uagcugcugu                                                   20


<210>  11615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11615
aaaaaaacau uaaaaauuua                                                   20


<210>  11616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11616
caaaaaaaac auuaaaaauu                                                   20


<210>  11617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11617
cucuguugcc caggcuggag                                                   20


<210>  11618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11618
guugcccagg cuggagugcg                                                   20


<210>  11619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11619
agccugggca acagagcgag                                                   20


<210>  11620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11620
gcucacugca accugcauuc                                                   20


<210>  11621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11621
cugcaaccug cauucaagug                                                   20


<210>  11622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11622
ugccucagcu ucccggauag                                                   20


<210>  11623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11623
gcuucccgga uagcugggau                                                   20


<210>  11624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11624
aaccccuggc cuuaaguaau                                                   20


<210>  11625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11625
gccucccaaa ggauuacagg                                                   20


<210>  11626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11626
caaaggauua caggugugag                                                   20


<210>  11627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11627
caccuguaau ccuuugggag                                                   20


<210>  11628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11628
uggcauauau uuccccaaau                                                   20


<210>  11629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11629
uuaacauaca aaaaagacau                                                   20


<210>  11630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11630
uagacagcuu caagauagga                                                   20


<210>  11631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11631
uaucuugaag cugucuagga                                                   20


<210>  11632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11632
gcccuacucu ugcccucugg                                                   20


<210>  11633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11633
ugcccucugg gaagggagag                                                   20


<210>  11634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11634
gggaagggag aggggcugau                                                   20


<210>  11635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11635
cuucccagag ggcaagagua                                                   20


<210>  11636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11636
cccuucccag agggcaagag                                                   20


<210>  11637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11637
accaucagcc ccucucccuu                                                   20


<210>  11638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11638
auaaaaaccc aagaggacag                                                   20


<210>  11639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11639
uggguuuuua uggaggcuuc                                                   20


<210>  11640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11640
gaacccuguc cucuuggguu                                                   20


<210>  11641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11641
cugaacccug uccucuuggg                                                   20


<210>  11642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11642
acguuacccg gaagcucucu                                                   20


<210>  11643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11643
agaaaccucc acguuacccg                                                   20


<210>  11644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11644
cuucuacggg gacagaagcu                                                   20


<210>  11645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11645
ugugcuuggg acccuuccag                                                   20


<210>  11646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11646
cuaugcaucu ucucaucugg                                                   20


<210>  11647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11647
ucuggcuguu caucuguauc                                                   20


<210>  11648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11648
gaguucugua ugcugaucua                                                   20


<210>  11649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11649
gagaaacaca uuuccugguu                                                   20


<210>  11650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11650
uuggguucaa uuaauuugcu                                                   20


<210>  11651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11651
guucccacaa gacugaaccc                                                   20


<210>  11652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11652
aucugugugg ucaggcgcug                                                   20


<210>  11653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11653
uucaagucug acggcaucua                                                   20


<210>  11654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11654
cauucaaguc ugacggcauc                                                   20


<210>  11655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11655
ccacccacaa gcaagcaauc                                                   20


<210>  11656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11656
agaaucaaca cagaauacuu                                                   20


<210>  11657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11657
cucaagaauc aacacagaau                                                   20


<210>  11658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11658
cacucaagaa ucaacacaga                                                   20


<210>  11659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11659
ggguggcuga auauacauau                                                   20


<210>  11660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11660
uacagcguau uccauaugua                                                   20


<210>  11661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11661
uccuacagcg uauuccauau                                                   20


<210>  11662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11662
cagauauuca uaacuccucc                                                   20


<210>  11663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11663
ccucacagau auucauaacu                                                   20


<210>  11664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11664
ucauggguca cguguucaaa                                                   20


<210>  11665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11665
gaucacgcua accccaacau                                                   20


<210>  11666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11666
cucugacguc aaaaggugaa                                                   20


<210>  11667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11667
gacgucaaaa ggugaagcag                                                   20


<210>  11668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11668
gcuucaccuu uugacgucag                                                   20


<210>  11669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11669
uguccucugc uucaccuuuu                                                   20


<210>  11670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11670
cugcaccgcc ucuggagacg                                                   20


<210>  11671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11671
ggagacggcc acggccacug                                                   20


<210>  11672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11672
agaggcggug cagugagggu                                                   20


<210>  11673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11673
guggucucuu accaggaagg                                                   20


<210>  11674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11674
uaccaggaag ggaagcauug                                                   20


<210>  11675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11675
gaugauuggc uaaaggcaau                                                   20


<210>  11676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11676
ucuauugccu uuagccaauc                                                   20


<210>  11677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11677
cucuucuauu gccuuuagcc                                                   20


<210>  11678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11678
agaaaaaaag aacagacauc                                                   20


<210>  11679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11679
gugugccccu uccuuaauac                                                   20


<210>  11680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11680
ccucagugug ccccuuccuu                                                   20


<210>  11681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11681
guuuuuaagg uuucucugag                                                   20


<210>  11682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11682
gaggucuccu cgaccaagaa                                                   20


<210>  11683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11683
gagaaaccuu aaaaacugag                                                   20


<210>  11684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11684
ucgaccaaga agcgguccgc                                                   20


<210>  11685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11685
accaagaagc gguccgcuca                                                   20


<210>  11686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11686
guuggcaggg guuuuaggau                                                   20


<210>  11687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11687
agggagcagu aaacaucaca                                                   20


<210>  11688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11688
cuugagguac auaagaaaau                                                   20


<210>  11689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11689
aaacaguguu ugaacauuuu                                                   20


<210>  11690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11690
guuaaaugaa aaacuucagc                                                   20


<210>  11691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11691
uuuaaauuua auuuggcuga                                                   20


<210>  11692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11692
auuaaacuca uuuaaauuua                                                   20


<210>  11693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11693
gaaucugcug ugauucuggg                                                   20


<210>  11694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11694
agggauaccu cguggucaga                                                   20


<210>  11695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11695
uggucagaac aaaucuauag                                                   20


<210>  11696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11696
aauuucuaua ugucacuucc                                                   20


<210>  11697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11697
ccuccaauuu cuauauguca                                                   20


<210>  11698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11698
gcauuugccu uauuuggaca                                                   20


<210>  11699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11699
cagcagugua cgagugaagu                                                   20


<210>  11700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11700
gcaguguacg agugaaguac                                                   20


<210>  11701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11701
uacacugcug agaguucaaa                                                   20


<210>  11702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11702
gguacugcca caggugcaga                                                   20


<210>  11703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11703
caagugagga ugucaggguu                                                   20


<210>  11704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11704
cuugggaguc ugcaccugug                                                   20


<210>  11705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11705
aauagagaag uauggagucc                                                   20


<210>  11706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11706
auuugagucc uuguggacga                                                   20


<210>  11707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11707
auacuucucu auuugagucc                                                   20


<210>  11708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11708
ggccauauuu aguuugcuuu                                                   20


<210>  11709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11709
auuuugagag auugaccaaa                                                   20


<210>  11710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11710
aaauugagaa aaugaccaaa                                                   20


<210>  11711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11711
caaaauugag aaaaugacca                                                   20


<210>  11712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11712
gagaaacagu agaacaguga                                                   20


<210>  11713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11713
gaggguuuca ggaccaaaua                                                   20


<210>  11714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11714
cuguucuacu guuucucaga                                                   20


<210>  11715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11715
guccuuguuc cuaccuuugc                                                   20


<210>  11716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11716
uuaugcugga acguccuguu                                                   20


<210>  11717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11717
ugcuaaaugu gacauaauca                                                   20


<210>  11718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11718
auuuuuguuu ggcuuagucu                                                   20


<210>  11719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11719
ugcacuaugu cccaacagac                                                   20


<210>  11720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11720
guccaaaaca auggccuccc                                                   20


<210>  11721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11721
cauaauuuua uuuuaauaaa                                                   20


<210>  11722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11722
cuuaggugag ugugggcggc                                                   20


<210>  11723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11723
ccuaagugag aaccuggaca                                                   20


<210>  11724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11724
gggucuugcc uuggcagcug                                                   20


<210>  11725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11725
caaagugcug ggauuauagg                                                   20


<210>  11726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11726
gccucccaaa gugcugggau                                                   20


<210>  11727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11727
ugaucugccc accucggccu                                                   20


<210>  11728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11728
ugaccucaug aucugcccac                                                   20


<210>  11729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11729
aucuccugac cucaugaucu                                                   20


<210>  11730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11730
acuaaaaaua caaaaaauua                                                   20


<210>  11731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11731
ggaggcugag gcaggagaau                                                   20


<210>  11732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11732
cgaguagcug ggacuacagg                                                   20


<210>  11733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11733
gccucccgag uagcugggac                                                   20


<210>  11734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11734
ugccucagcc ucccgaguag                                                   20


<210>  11735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11735
cggguucaug ccauucuccu                                                   20


<210>  11736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11736
gccucccggg uucaugccau                                                   20


<210>  11737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11737
cugcaagcuc cgccucccgg                                                   20


<210>  11738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11738
gcucacugca agcuccgccu                                                   20


<210>  11739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11739
agccugggug acagagcgag                                                   20


<210>  11740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11740
gucacccagg cuggagggca                                                   20


<210>  11741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11741
cucugucacc caggcuggag                                                   20


<210>  11742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11742
gucucaaaaa acaaaaacaa                                                   20


<210>  11743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11743
aaaaacaaaa acaaaaacaa                                                   20


<210>  11744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11744
auuccaauau uauaauaauc                                                   20


<210>  11745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11745
guauggccug guuuuuccua                                                   20


<210>  11746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11746
uaucucugua uggccugguu                                                   20


<210>  11747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11747
cccugucccu ucagcuccua                                                   20


<210>  11748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11748
ucuucugguc acuucucacc                                                   20


<210>  11749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11749
cacucgucuu cuggucacuu                                                   20


<210>  11750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11750
gucacgcuca gacagggcca                                                   20


<210>  11751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11751
gacagggcca cuagagggcu                                                   20


<210>  11752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11752
aguggcccug ucugagcgug                                                   20


<210>  11753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11753
cuggucuagu gguaaugaca                                                   20


<210>  11754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11754
cuucccuggu cggcuaagua                                                   20


<210>  11755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11755
cuuuggccag gggagagggg                                                   20


<210>  11756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11756
ccuggccaaa gggagacucc                                                   20


<210>  11757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11757
ccccuggcca aagggagacu                                                   20


<210>  11758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11758
gccccucucc ccuggccaaa                                                   20


<210>  11759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11759
aaccccuccg ccccucuccc                                                   20


<210>  11760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11760
gcuccaccau cucuugugga                                                   20


<210>  11761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11761
accaucucuu guggaaggcc                                                   20


<210>  11762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11762
uguggaaggc cugacaucag                                                   20


<210>  11763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11763
ggauggcugu gggcgggccu                                                   20


<210>  11764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11764
cugugaugcu gugcuucagc                                                   20


<210>  11765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11765
uguuucacuu ucauguuccg                                                   20


<210>  11766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11766
guacaccugg cuccaucuuc                                                   20


<210>  11767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11767
aucuucuaga uagcaguagc                                                   20


<210>  11768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11768
ucucucucuc cgccucggcu                                                   20


<210>  11769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11769
cucucuccgc cucggcuacc                                                   20


<210>  11770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11770
cucuccgccu cggcuaccaa                                                   20


<210>  11771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11771
cuccgccucg gcuaccaaac                                                   20


<210>  11772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11772
ccgccucggc uaccaaacag                                                   20


<210>  11773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11773
gccucggcua ccaaacaggg                                                   20


<210>  11774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11774
gcuaccaaac agggaagggc                                                   20


<210>  11775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11775
aaugauaggu caggucacgc                                                   20


<210>  11776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11776
cacuccuuac ccugcccccu                                                   20


<210>  11777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11777
uuacccugcc cccuugucuu                                                   20


<210>  11778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11778
gugucuaggu gguagugguc                                                   20


<210>  11779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11779
uugucuugug uccuuauuuc                                                   20


<210>  11780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11780
caucuccgca ggugaggaga                                                   20


<210>  11781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11781
ucuccgcagg ugaggagaaa                                                   20


<210>  11782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11782
gcaggugagg agaaaaaccc                                                   20


<210>  11783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11783
ccugcggaga ugagagauca                                                   20


<210>  11784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11784
ucaccugcgg agaugagaga                                                   20


<210>  11785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11785
ccuguagggu ccagcccuac                                                   20


<210>  11786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11786
cgccuguagg guccagcccu                                                   20


<210>  11787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11787
caguuaccau cguuuugggu                                                   20


<210>  11788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11788
guuaccaucg uuuuggguuu                                                   20


<210>  11789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11789
gcacgucauu cauagguuac                                                   20


<210>  11790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11790
uggucacaca uuucuuucag                                                   20


<210>  11791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11791
ucaacuggaa uggcagaagc                                                   20


<210>  11792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11792
cuucaacugg aauggcagaa                                                   20


<210>  11793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11793
agaacaacaa auggucucuc                                                   20


<210>  11794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11794
aagguuuuaa augucugcau                                                   20


<210>  11795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11795
caaagguuuu aaaugucugc                                                   20


<210>  11796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11796
cuggugcgcu gcauucucuc                                                   20


<210>  11797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11797
caguaaucau aauaauaguc                                                   20


<210>  11798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11798
ugguauuauc cucccaguaa                                                   20


<210>  11799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11799
uuacccaggg ucccuauaca                                                   20


<210>  11800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11800
uugucugauc uauuugauuu                                                   20


<210>  11801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11801
uaucuagcuc auugucugau                                                   20


<210>  11802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11802
cucaacuaag uggccuuuuc                                                   20


<210>  11803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11803
acuaaguggc cuuuucauua                                                   20


<210>  11804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11804
cacaacugaa ucucuauaau                                                   20


<210>  11805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11805
auaauaccug auguauuucu                                                   20


<210>  11806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11806
cuaggccaca ggugccagca                                                   20


<210>  11807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11807
acuguaaagg cuauaguuac                                                   20


<210>  11808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11808
ugauaggcug uauagcagac                                                   20


<210>  11809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11809
uuuacucuaa accauggaaa                                                   20


<210>  11810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11810
aaaccaugga aaagugaugc                                                   20


<210>  11811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11811
uccagaaggg caucacuuuu                                                   20


<210>  11812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11812
uggcaaugcc cucuuuaacc                                                   20


<210>  11813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11813
uuaacccaua guguggguua                                                   20


<210>  11814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11814
uaacccacac uauggguuaa                                                   20


<210>  11815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11815
ucuuaaccca cacuaugggu                                                   20


<210>  11816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11816
uuaaaguuuc ucaccuacac                                                   20


<210>  11817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11817
ccuacacugg accuucaucu                                                   20


<210>  11818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11818
augaauaaua gaaaugaaaa                                                   20


<210>  11819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11819
aagauaagag ucucauggcc                                                   20


<210>  11820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11820
uaucuuugag uaucuguucc                                                   20


<210>  11821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11821
uggccaggcg ugguggugca                                                   20


<210>  11822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11822
caaagugcug ggauuacagg                                                   20


<210>  11823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11823
gccucccaaa gugcugggau                                                   20


<210>  11824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11824
ggugauccgc ccaccucggc                                                   20


<210>  11825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11825
acuaaaaaua caaaaauuag                                                   20


<210>  11826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11826
gaaggcugag guaugagaau                                                   20


<210>  11827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11827
gccuuccgag uagcugguau                                                   20


<210>  11828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11828
uaccucagcc uuccgaguag                                                   20


<210>  11829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11829
uggguucaag cgauucucau                                                   20


<210>  11830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11830
gccuccuggg uucaagcgau                                                   20


<210>  11831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11831
cugcaaccuc ugccuccugg                                                   20


<210>  11832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11832
gcucacugca accucugccu                                                   20


<210>  11833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11833
agccugggug acagagcaag                                                   20


<210>  11834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11834
gucacccagg cuggagugcg                                                   20


<210>  11835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11835
aucuccaaaa aagaaaaaaa                                                   20


<210>  11836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11836
aaaaaagaaa aaaaaaagag                                                   20


<210>  11837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11837
uuuuuuuuuc uuuuuuggag                                                   20


<210>  11838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11838
cuuuuuuuuu ucuuuuuugg                                                   20


<210>  11839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11839
ugacaguaga agucuugauc                                                   20


<210>  11840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11840
ccagaagaug gcauccuuga                                                   20


<210>  11841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11841
ccccagaaga uggcauccuu                                                   20


<210>  11842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11842
uggaacugua cacccauugg                                                   20


<210>  11843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11843
guugugagau uaugaaccca                                                   20


<210>  11844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11844
caacugagaa ggguccaucc                                                   20


<210>  11845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11845
gauguucuca gaagauccag                                                   20


<210>  11846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11846
gaagauccag ucuucggguu                                                   20


<210>  11847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11847
gugaaccaua gaaaaauaua                                                   20


<210>  11848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11848
uaacaugcga gagcuuuuau                                                   20


<210>  11849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11849
cauguuaaga gggcugaugu                                                   20


<210>  11850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11850
cgcauguuaa gagggcugau                                                   20


<210>  11851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11851
aaaaaaaaaa aguguauaug                                                   20


<210>  11852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11852
gucacccagg cuggagugca                                                   20


<210>  11853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11853
agccugggug acagagauuc                                                   20


<210>  11854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11854
gcucacucca accucugccu                                                   20


<210>  11855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11855
cuccaaccuc ugccucccac                                                   20


<210>  11856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11856
aaccucugcc ucccacacac                                                   20


<210>  11857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11857
gccucccaca caccaaugua                                                   20


<210>  11858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11858
cacacaccaa uguauuuaau                                                   20


<210>  11859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11859
ucauggaaaa gauaaaguaa                                                   20


<210>  11860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11860
ggaaggacaa gguggccguc                                                   20


<210>  11861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11861
gugaguccau acuuaauuaa                                                   20


<210>  11862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11862
cggagaacca ggacggccac                                                   20


<210>  11863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11863
ugaaucccag uugcuucucc                                                   20


<210>  11864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11864
aaauuaggug cauugcacgg                                                   20


<210>  11865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11865
uuucuuggua uucaauuaau                                                   20


<210>  11866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11866
uaaaagacac cauacuuuug                                                   20


<210>  11867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11867
ggcauauuag aauuuuagaa                                                   20


<210>  11868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11868
ucagguuaca uuuuagugaa                                                   20


<210>  11869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11869
ucuucagguu acauuuuagu                                                   20


<210>  11870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11870
cuuuggaugc uuuaggggau                                                   20


<210>  11871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11871
uuggaugcuu uaggggaucu                                                   20


<210>  11872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11872
guaacacccc aaaguuagag                                                   20


<210>  11873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11873
aacuuugggg uguuacagag                                                   20


<210>  11874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11874
uggucaaacu gguuaagcau                                                   20


<210>  11875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11875
ccucaugguc aaacugguua                                                   20


<210>  11876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11876
aucuaaaaca cacacacaca                                                   20


<210>  11877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11877
agccugggca acaagaauga                                                   20


<210>  11878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11878
gcuaccgcaa ccucugccuc                                                   20


<210>  11879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11879
gccucccagg uucaaguaau                                                   20


<210>  11880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11880
cagguucaag uaauucuccu                                                   20


<210>  11881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11881
ugccucagcc ucucuaguag                                                   20


<210>  11882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11882
gccucucuag uagcugggau                                                   20


<210>  11883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11883
cuaguagcug ggauuacagg                                                   20


<210>  11884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11884
aguagcuggg auuacaggca                                                   20


<210>  11885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11885
acuaaaaaua caaaauuagc                                                   20


<210>  11886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11886
acguugguca ggcuggucuc                                                   20


<210>  11887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11887
aacucccgac cucaggugau                                                   20


<210>  11888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11888
cgaccucagg ugauccaccu                                                   20


<210>  11889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11889
ggugauccac cugccuuggc                                                   20


<210>  11890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11890
caccuauaau cccagcacuu                                                   20


<210>  11891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11891
aauuuaaaag uugagaggcu                                                   20


<210>  11892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11892
acuuuuaaau uugagcagca                                                   20


<210>  11893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11893
caacuuuuaa auuugagcag                                                   20


<210>  11894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11894
gggauaugau guggagagcu                                                   20


<210>  11895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11895
acaucauauc ccugagggcc                                                   20


<210>  11896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11896
ccacaucaua ucccugaggg                                                   20


<210>  11897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11897
gggaaaggga auccagaagc                                                   20


<210>  11898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11898
cucucucugu guguucaaac                                                   20


<210>  11899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11899
cucucugugu guucaaacug                                                   20


<210>  11900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11900
cucugugugu ucaaacuggu                                                   20


<210>  11901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11901
cuguguguuc aaacugguug                                                   20


<210>  11902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11902
guguguucaa acugguugaa                                                   20


<210>  11903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11903
ucuguaaagu uuugauuaau                                                   20


<210>  11904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11904
guaaaguuuu gauuaaugga                                                   20


<210>  11905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11905
caaauccuuu uuuccauuaa                                                   20


<210>  11906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11906
ggcuguagug aaucucguag                                                   20


<210>  11907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11907
uaggcuuuau gugucuuccc                                                   20


<210>  11908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11908
ccgcucaaga uggcccaaca                                                   20


<210>  11909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11909
agauggccca acaagcuggu                                                   20


<210>  11910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11910
ucuaguuuuu uuguuuguuu                                                   20


<210>  11911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11911
aucuuguuuu aagucuuugg                                                   20


<210>  11912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11912
caaagacuua aaacaagaug                                                   20


<210>  11913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11913
accuuccaag uggaacagga                                                   20


<210>  11914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11914
acaaucuauc uugaguaguu                                                   20


<210>  11915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11915
agauagauug uagagcuaac                                                   20


<210>  11916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11916
uaacuacuca agauagauug                                                   20


<210>  11917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11917
agacucuuuc ugggaagggc                                                   20


<210>  11918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11918
uucugggaag ggcaauggag                                                   20


<210>  11919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11919
auugcccuuc ccagaaagag                                                   20


<210>  11920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11920
uucccuaagc caggaaucaa                                                   20


<210>  11921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11921
cccuccacaa acugucuuga                                                   20


<210>  11922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11922
acaaacuguc uugaauugcc                                                   20


<210>  11923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11923
gagcaccugg gagguuacuu                                                   20


<210>  11924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11924
gagaaaggca auucaagaca                                                   20


<210>  11925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11925
caggugcucu gagaaaggca                                                   20


<210>  11926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11926
uuaauaaaag uucuuuuaaa                                                   20


<210>  11927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11927
aacagccugg gacuccuugg                                                   20


<210>  11928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11928
uugggaaaac aggaggugcc                                                   20


<210>  11929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11929
uguuuuccca aggaguccca                                                   20


<210>  11930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11930
ggcaccuccu guuuucccaa                                                   20


<210>  11931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11931
guuuuacuca ugaaacccca                                                   20


<210>  11932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11932
ugaaacccca gaaauuggaa                                                   20


<210>  11933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11933
guucuguuuu gcauuggauu                                                   20


<210>  11934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11934
augugaagua auuucugaua                                                   20


<210>  11935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11935
cucuuuuuug ggggggaucc                                                   20


<210>  11936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11936
uuuuuggggg ggauccagga                                                   20


<210>  11937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11937
uuuuuauacc agauccugga                                                   20


<210>  11938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11938
ggcugggcau gguggcucac                                                   20


<210>  11939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11939
cgccuguaau ccuagcacuu                                                   20


<210>  11940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11940
aagugcuagg auuacaggcg                                                   20


<210>  11941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11941
caaagugcua ggauuacagg                                                   20


<210>  11942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11942
gccucucaaa gugcuaggau                                                   20


<210>  11943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11943
ggcaauccac ccaccucggc                                                   20


<210>  11944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11944
ggaguucgag accagccugg                                                   20


<210>  11945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11945
ugagcucagg caauccaccc                                                   20


<210>  11946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11946
aacuccugag cucaggcaau                                                   20


<210>  11947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11947
acuaaaauaa aaauaaaaaa                                                   20


<210>  11948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11948
caaauagcug ggacuauagg                                                   20


<210>  11949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11949
gccucccaaa uagcugggac                                                   20


<210>  11950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11950
uggguuaaag cgauucuucu                                                   20


<210>  11951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11951
gccuccuggg uuaaagcgau                                                   20


<210>  11952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11952
guucacugca accuccgccu                                                   20


<210>  11953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11953
agccugguga cagagcaaga                                                   20


<210>  11954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11954
gucaccaggc uggagugcag                                                   20


<210>  11955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11955
gucucaaaaa aaaaaaagag                                                   20


<210>  11956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11956
aaaaaaaaaa agagacccuu                                                   20


<210>  11957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11957
uuuuuuuuuu ugagacggag                                                   20


<210>  11958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11958
aaaaauuaag ggucucuuuu                                                   20


<210>  11959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11959
auccuaaagc caguaaucca                                                   20


<210>  11960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11960
uuuauauaaa cauuaaacac                                                   20


<210>  11961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11961
aauugccagg cacauuggcu                                                   20


<210>  11962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11962
cgccuauaau cccaacacuu                                                   20


<210>  11963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11963
caaaguguug ggauuauagg                                                   20


<210>  11964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11964
gccucccaaa guguugggau                                                   20


<210>  11965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11965
ggcgauccac ccaccucagc                                                   20


<210>  11966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11966
ugaccucagg cgauccaccc                                                   20


<210>  11967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11967
aacuccugac cucaggcgau                                                   20


<210>  11968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11968
acuaaaaaua caaaaauuag                                                   20


<210>  11969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11969
ggaggcugag gcaggagaau                                                   20


<210>  11970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11970
ugaguagcug ggauuaccag                                                   20


<210>  11971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11971
gccuccugag uagcugggau                                                   20


<210>  11972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11972
ugccucagcc uccugaguag                                                   20


<210>  11973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11973
ggagguggag guugcccuga                                                   20


<210>  11974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11974
ugaguucaag ugauucuccu                                                   20


<210>  11975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11975
accuccugag uucaagugau                                                   20


<210>  11976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11976
gggcaaccuc caccuccuga                                                   20


<210>  11977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11977
gucauccaga cuugggugca                                                   20


<210>  11978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11978
cucugucauc cagacuuggg                                                   20


<210>  11979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11979
gucucaaaau aaaaauaaaa                                                   20


<210>  11980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11980
aaauaaaaau aaaaauaaaa                                                   20


<210>  11981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11981
uuuauuuauu uuuauuuuua                                                   20


<210>  11982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11982
aauuaauugg cuuuaagaaa                                                   20


<210>  11983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11983
uuuuucuuaa agccaauuaa                                                   20


<210>  11984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11984
aaugccuuuu agugcaugua                                                   20


<210>  11985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11985
aaaaaaaaaa aaaaaaagaa                                                   20


<210>  11986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11986
aucucaaaaa aaaaaaaaaa                                                   20


<210>  11987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11987
uguugcccag gcuggagucc                                                   20


<210>  11988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11988
agccugggca acaagaguga                                                   20


<210>  11989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11989
cuacaacguc ugccucucgg                                                   20


<210>  11990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11990
cgggguucaa gcaauucucc                                                   20


<210>  11991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11991
ggguucaagc aauucuccug                                                   20


<210>  11992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11992
ugccucagcc ucccgaguag                                                   20


<210>  11993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11993
gccucccgag uagcuuggau                                                   20


<210>  11994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11994
cgaguagcuu ggauuauagg                                                   20


<210>  11995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11995
ggaggcugag gcaggagaau                                                   20


<210>  11996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11996
acuaaaaaua caaaaauuag                                                   20


<210>  11997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11997
ucucuacuaa aaauacaaaa                                                   20


<210>  11998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11998
ugaccucaug auccccccgc                                                   20


<210>  11999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  11999
ugaucccccc gccuccgccu                                                   20


<210>  12000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12000
gccucccaaa gugcugggau                                                   20


<210>  12001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12001
caaagugcug ggauuacagg                                                   20


<210>  12002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12002
caccuguaau cccagcacuu                                                   20


<210>  12003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12003
aaaauaauuu gaacaauuua                                                   20


<210>  12004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12004
uaugguaaau ucuugcccua                                                   20


<210>  12005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12005
uuuuaaacaa ccaguuauuu                                                   20


<210>  12006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12006
uuuuaaacac cccucuuuuu                                                   20


<210>  12007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12007
ucuuuuuaaa caccccucuu                                                   20


<210>  12008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12008
cuuguccuaa acacuccucu                                                   20


<210>  12009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12009
uagcaucuuu uacuuuuggu                                                   20


<210>  12010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12010
cacaccuugc auguaaaacu                                                   20


<210>  12011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12011
ucacacaccu ugcauguaaa                                                   20


<210>  12012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12012
ccucacacac cuugcaugua                                                   20


<210>  12013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12013
aaacuaggca aaaauuuaca                                                   20


<210>  12014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12014
aacuuuuagc uuuaucuuau                                                   20


<210>  12015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12015
uuuaaauuua gucaauaugu                                                   20


<210>  12016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12016
aaaaaaaaaa auagaaagaa                                                   20


<210>  12017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12017
aucucaaaaa aaaaaaauag                                                   20


<210>  12018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12018
cucugucacc caggcuggag                                                   20


<210>  12019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12019
gucacccagg cuggagugca                                                   20


<210>  12020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12020
agccugggug acagagcgag                                                   20


<210>  12021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12021
uggcucacug caaccucugc                                                   20


<210>  12022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12022
cugcaaccuc ugcccccugg                                                   20


<210>  12023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12023
gcccccuggg uuuaagcgau                                                   20


<210>  12024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12024
ugccucagcc ucuggaguag                                                   20


<210>  12025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12025
gccucuggag uagcugugau                                                   20


<210>  12026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12026
ggaguagcug ugauuauagg                                                   20


<210>  12027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12027
agaggcugag gcaggagaau                                                   20


<210>  12028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12028
acuaaaaaua caaacauuag                                                   20


<210>  12029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12029
ugaccucgug aucugcccgc                                                   20


<210>  12030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12030
ugaucugccc gccuccaccu                                                   20


<210>  12031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12031
accucccaaa gugcuaggau                                                   20


<210>  12032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12032
caaagugcua ggauuacagg                                                   20


<210>  12033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12033
ugccuguaau ccuagcacuu                                                   20


<210>  12034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12034
uucacaaaaa uuguaagggc                                                   20


<210>  12035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12035
caccuguaau cccaucacuu                                                   20


<210>  12036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12036
caaagugaug ggauuacagg                                                   20


<210>  12037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12037
gccucccaaa gugaugggau                                                   20


<210>  12038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12038
ugaucuaccu gccucagccu                                                   20


<210>  12039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12039
ugaccucgug aucuaccugc                                                   20


<210>  12040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12040
aucuccugac cucgugaucu                                                   20


<210>  12041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12041
ggaggcugag gcaguagaau                                                   20


<210>  12042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12042
ugaguagcug ggacuacagg                                                   20


<210>  12043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12043
gccuccugag uagcugggac                                                   20


<210>  12044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12044
uggguucaug ccauucuacu                                                   20


<210>  12045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12045
gccuccuggg uucaugccau                                                   20


<210>  12046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12046
cugcaagcuc ugccuccugg                                                   20


<210>  12047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12047
agccugggca acacagcgag                                                   20


<210>  12048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12048
cuguguugcc caggcuggag                                                   20


<210>  12049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12049
gucuaaaaaa aaaaaaaguc                                                   20


<210>  12050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12050
aacuagcccu ggguugggcc                                                   20


<210>  12051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12051
ggguuaaaaa uggguuaaag                                                   20


<210>  12052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12052
guaaaguccc ucuggguuaa                                                   20


<210>  12053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12053
ccucaguaaa gucccucugg                                                   20


<210>  12054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12054
aacccaaucc caugcuuuac                                                   20


<210>  12055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12055
uuuggauugc gauaguaacu                                                   20


<210>  12056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12056
caaaaaucaa aucugcuaac                                                   20


<210>  12057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12057
gcuucccuug auuaauuuag                                                   20


<210>  12058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12058
uacaucugac ugggucugaa                                                   20


<210>  12059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12059
aacuggaucc aggccgguua                                                   20


<210>  12060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12060
gagagcucga aacacaaacu                                                   20


<210>  12061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12061
gaguuuucuu ugugcaaauu                                                   20


<210>  12062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12062
cugaguuuuc uuugugcaaa                                                   20


<210>  12063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12063
aaacacaaac uguggaucuc                                                   20


<210>  12064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12064
aaaauccaag agaggacuua                                                   20


<210>  12065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12065
uggauuuugg agauccacag                                                   20


<210>  12066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12066
cuuggauuuu ggagauccac                                                   20


<210>  12067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12067
gagaaaucaa uggacacaag                                                   20


<210>  12068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12068
gagcagcugg ggaucaugga                                                   20


<210>  12069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12069
gugccccagg ggucauuaga                                                   20


<210>  12070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12070
uuuaaauuua auucggcuga                                                   20


<210>  12071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12071
gaaucccagc agauucagag                                                   20


<210>  12072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12072
gaaucugcug ggauucugag                                                   20


<210>  12073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12073
cugaaucugc ugggauucug                                                   20


<210>  12074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12074
agggaugcuu cauggucaga                                                   20


<210>  12075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12075
aauuucugua cgucacuucc                                                   20


<210>  12076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12076
ccuccaauuu cuguacguca                                                   20


<210>  12077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12077
gcauuugccu cauuugaacu                                                   20


<210>  12078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12078
uuugaacucu cagcagugua                                                   20


<210>  12079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12079
cagcagugua ugagugaaau                                                   20


<210>  12080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12080
gcaguguaug agugaaauau                                                   20


<210>  12081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12081
uacacugcug agaguucaaa                                                   20


<210>  12082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12082
gcuacuguua caggugcgua                                                   20


<210>  12083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12083
aauacagaag uacagagucc                                                   20


<210>  12084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12084
guacuucugu auuugagucu                                                   20


<210>  12085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12085
ggccauauuu aguuugcuuu                                                   20


<210>  12086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12086
uugcaucuug uaaagcugaa                                                   20


<210>  12087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12087
guccccauga aacacuaauu                                                   20


<210>  12088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12088
guuuuuauga auuugacuac                                                   20


<210>  12089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12089
acaucuccug ucucagugga                                                   20


<210>  12090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12090
ugucucagug gaaucagaca                                                   20


<210>  12091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12091
guggaaucag acagcauuug                                                   20


<210>  12092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12092
aaaaaaaaag aaaaagaaaa                                                   20


<210>  12093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12093
gccucaaaaa aaaaagaaaa                                                   20


<210>  12094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12094
cucugucgcc caggcuggag                                                   20


<210>  12095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12095
gucgcccagg cuggagugca                                                   20


<210>  12096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12096
agccugggcg acagagcgag                                                   20


<210>  12097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12097
gcucacugca accucugccu                                                   20


<210>  12098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12098
cugcaaccuc ugccucccgg                                                   20


<210>  12099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12099
gccucccggg uucaagcaau                                                   20


<210>  12100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12100
cggguucaag caauacuccu                                                   20


<210>  12101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12101
ugucucagcc ucccgaguag                                                   20


<210>  12102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12102
gccucccgag uagcugggac                                                   20


<210>  12103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12103
cgaguagcug ggacuacagg                                                   20


<210>  12104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12104
ggaggcugag acaggaguau                                                   20


<210>  12105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12105
acuaaagaua caaaaaauua                                                   20


<210>  12106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12106
ugaccucgug aucugcccgc                                                   20


<210>  12107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12107
ugaucugccc gccucggccu                                                   20


<210>  12108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12108
gccucccaaa gugcugggau                                                   20


<210>  12109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12109
caaagugcug ggauuacagg                                                   20


<210>  12110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12110
cgccuguaau cccagcacuu                                                   20


<210>  12111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12111
agguucaucc auguuguagu                                                   20


<210>  12112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12112
uauuuaaggc caaaacuauu                                                   20


<210>  12113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12113
uggggucagc auugggaccc                                                   20


<210>  12114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12114
cuugggguca gcauugggac                                                   20


<210>  12115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12115
agaaagaauu cagacgaguc                                                   20


<210>  12116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12116
ucugaauucu uucuugagca                                                   20


<210>  12117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12117
auuccuuggc uuucuuagua                                                   20


<210>  12118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12118
augggcagag cagccccgau                                                   20


<210>  12119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12119
gcccauggag uagccauucu                                                   20


<210>  12120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12120
aaaauaaaua aauaaauaaa                                                   20


<210>  12121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12121
gucucaaaaa uaaauaaaua                                                   20


<210>  12122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12122
cuuuguugcc caggcuggag                                                   20


<210>  12123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12123
agccugggca acaaagggag                                                   20


<210>  12124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12124
gcucacugca agcuccgccu                                                   20


<210>  12125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12125
cugcaagcuc cgccucccgg                                                   20


<210>  12126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12126
gccucccggg uucaugccau                                                   20


<210>  12127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12127
cggguucaug ccauucuucu                                                   20


<210>  12128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12128
gccuccugag uagcugggac                                                   20


<210>  12129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12129
ugaguagcug ggacuauagg                                                   20


<210>  12130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12130
ggaggcugag gcagaagaau                                                   20


<210>  12131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12131
acuaaaaaua caaaaaauua                                                   20


<210>  12132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12132
aucuccugac cuugugaucc                                                   20


<210>  12133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12133
ugaccuugug auccgcccgc                                                   20


<210>  12134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12134
gccucccaaa gugcugggau                                                   20


<210>  12135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12135
caaagugcug ggauuacagg                                                   20


<210>  12136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12136
cgccuguaau cccagcacuu                                                   20


<210>  12137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12137
uguuuagcau auaaucaaga                                                   20


<210>  12138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12138
ugaauaaucc accucuuguu                                                   20


<210>  12139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12139
guucugggaa uugcccaccc                                                   20


<210>  12140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12140
ccuuuuuaga acauauaggg                                                   20


<210>  12141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12141
cgccuguaau cccagcacuu                                                   20


<210>  12142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12142
caaagugcug ggauuacagg                                                   20


<210>  12143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12143
ggucaucugc ccgccuuggc                                                   20


<210>  12144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12144
ugaccucagg ucaucugccc                                                   20


<210>  12145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12145
aacuccugac cucaggucau                                                   20


<210>  12146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12146
auguugguca agcuggucuc                                                   20


<210>  12147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12147
acuaaaaaua aaaaauuagc                                                   20


<210>  12148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12148
cagcuacucg ggaggcugag                                                   20


<210>  12149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12149
ggaggcugag gcaggagaau                                                   20


<210>  12150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12150
cgaguagcug ggaguacagg                                                   20


<210>  12151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12151
gccucccgag uagcugggag                                                   20


<210>  12152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12152
ugccucagcc ucccgaguag                                                   20


<210>  12153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12153
gcuucccggg uucaagcgau                                                   20


<210>  12154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12154
ccacaaccuc ggcuucccgg                                                   20


<210>  12155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12155
gcucaccaca accucggcuu                                                   20


<210>  12156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12156
agccugcaca acaagaauga                                                   20


<210>  12157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12157
gucucaaaag aaaaaaaaaa                                                   20


<210>  12158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12158
aaagaaaaaa aaaaaauaga                                                   20


<210>  12159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12159
caccagcccc augacaguuu                                                   20


<210>  12160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12160
uuauaagcua auuauaaugc                                                   20


<210>  12161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12161
cagcucauua uaagcuaauu                                                   20


<210>  12162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12162
gguuguucuc acagcucauu                                                   20


<210>  12163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12163
uaccucaucc ugugacuaug                                                   20


<210>  12164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12164
uccugugacu augaaugccu                                                   20


<210>  12165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12165
ugggaacgcg gcccagcagg                                                   20


<210>  12166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12166
uuuuaccccg ccccuauuca                                                   20


<210>  12167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12167
gacauauuag cugcaucauu                                                   20


<210>  12168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12168
gucacccagg cuggagugcu                                                   20


<210>  12169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12169
agccugggug acagagcaag                                                   20


<210>  12170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12170
gcucacugca aucuccaccu                                                   20


<210>  12171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12171
cugcaaucuc caccuccgag                                                   20


<210>  12172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12172
accuccgagg uuccagcgau                                                   20


<210>  12173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12173
gagguuccag cgauucucuu                                                   20


<210>  12174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12174
gagguggaga uugcagugag                                                   20


<210>  12175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12175
ugccucagcc ucccgaguag                                                   20


<210>  12176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12176
gccucccgag uagcugggac                                                   20


<210>  12177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12177
cgaguagcug ggacuacagg                                                   20


<210>  12178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12178
ggaggcugag gcaagagaau                                                   20


<210>  12179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12179
acuaaaaaca caaaaauuag                                                   20


<210>  12180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12180
aacuccuggg cuuaagcaau                                                   20


<210>  12181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12181
ugggcuuaag caauacagcc                                                   20


<210>  12182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12182
caaaguguug ggauuacaag                                                   20


<210>  12183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12183
ugcuuguaau cccaacacuu                                                   20


<210>  12184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12184
uuuuacauuu ccacuuguua                                                   20


<210>  12185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12185
ggccaguuuu caguuuaaca                                                   20


<210>  12186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12186
gccaguuccu gcagccagac                                                   20


<210>  12187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12187
caggccgcaa acuguucaaa                                                   20


<210>  12188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12188
gaacacaguu ugaacaguuu                                                   20


<210>  12189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12189
cuucugcuuu cuguggccac                                                   20


<210>  12190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12190
agggaugcug uguggucaaa                                                   20


<210>  12191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12191
cugaaucugc ugugauucug                                                   20


<210>  12192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12192
guucaauuca auuuguugga                                                   20


<210>  12193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12193
acuuccucau aaauaaguca                                                   20


<210>  12194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12194
uaaauaaguc auuuuaaaug                                                   20


<210>  12195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12195
auguccaaaa auagaaaauu                                                   20


<210>  12196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12196
aaaaaagaaa aaaaaaauga                                                   20


<210>  12197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12197
gucucaaaaa aagaaaaaaa                                                   20


<210>  12198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12198
cuccgucacc caggcuggag                                                   20


<210>  12199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12199
gucacccagg cuggagugca                                                   20


<210>  12200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12200
agccugggug acggagcgag                                                   20


<210>  12201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12201
accucccucc ucagccuccu                                                   20


<210>  12202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12202
cuccucagcc uccugaguag                                                   20


<210>  12203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12203
ucagccuccu gaguagcugg                                                   20


<210>  12204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12204
gccuccugag uagcugggau                                                   20


<210>  12205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12205
ugaguagcug ggauuacagg                                                   20


<210>  12206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12206
ggaggcugag gagggaggug                                                   20


<210>  12207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12207
acuaaaaaua caaaaauuag                                                   20


<210>  12208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12208
aacuccugac cucagguggu                                                   20


<210>  12209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12209
ugaccucagg ugguccaccu                                                   20


<210>  12210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12210
ggugguccac cugccuuggc                                                   20


<210>  12211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12211
caaaaugcug ggauuacagg                                                   20


<210>  12212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12212
ggccuguaau cccagcauuu                                                   20


<210>  12213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12213
ucuucuugau auuaauguug                                                   20


<210>  12214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12214
aaaaaaaaaa caaaaaacac                                                   20


<210>  12215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12215
gucucaaaaa aaaaaacaaa                                                   20


<210>  12216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12216
uucauucugu cacccaggcu                                                   20


<210>  12217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12217
agccugggug acagaaugaa                                                   20


<210>  12218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12218
gcucacugca accucugucu                                                   20


<210>  12219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12219
cugcaaccuc ugucuccugg                                                   20


<210>  12220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12220
gucuccuggg uuccagugau                                                   20


<210>  12221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12221
uggguuccag ugauucuccu                                                   20


<210>  12222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12222
ugcgucgguc uccugaguag                                                   20


<210>  12223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12223
ugaguagcug uguuccuggg                                                   20


<210>  12224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12224
ggagaccgac gcaggagaau                                                   20


<210>  12225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12225
ucagaaaagu gauaggaggu                                                   20


<210>  12226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12226
uaucacuuuu cugaagagug                                                   20


<210>  12227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12227
uuucuacauu uccuuacuaa                                                   20


<210>  12228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12228
guuggugucu cuucaaucuu                                                   20


<210>  12229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12229
ucaaucuuuc cucacacuuu                                                   20


<210>  12230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12230
cacuuuucuu ggguuuuucc                                                   20


<210>  12231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12231
ugauucagga aaaacccaag                                                   20


<210>  12232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12232
uuuuguugcc caggcuagag                                                   20


<210>  12233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12233
agccugggca acaaaaugag                                                   20


<210>  12234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12234
ucauacuccu gggcucaagu                                                   20


<210>  12235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12235
uacuccuggg cucaagugau                                                   20


<210>  12236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12236
ugggcucaag ugauccuucc                                                   20


<210>  12237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12237
agugauccuu ccaccucuga                                                   20


<210>  12238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12238
gaaaccccaa aauuugagaa                                                   20


<210>  12239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12239
aauuuugggg uuucagaggu                                                   20


<210>  12240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12240
uuuaauuuag aaaguuuauu                                                   20


<210>  12241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12241
accuuggcaa aauaaacuuu                                                   20


<210>  12242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12242
uauaucauca caggugugca                                                   20


<210>  12243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12243
guaucugccu aaauaauuuc                                                   20


<210>  12244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12244
guaagguuuu cuuuucaaug                                                   20


<210>  12245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12245
uuguuagaaa agaaaaugcu                                                   20


<210>  12246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12246
auuuuacagg cugcucuuug                                                   20


<210>  12247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12247
aucuucccuu uccuugucaa                                                   20


<210>  12248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12248
uuacugugca caugguugac                                                   20


<210>  12249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12249
ggggacacua uguugccugc                                                   20


<210>  12250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12250
acucggggga cacuauguug                                                   20


<210>  12251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12251
ccuuuuauua ugcaaauugg                                                   20


<210>  12252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12252
ucaagccugu cuauaaaacc                                                   20


<210>  12253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12253
agccugucua uaaaacccug                                                   20


<210>  12254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12254
cucucuauag gagacagcua                                                   20


<210>  12255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12255
cucuauagga gacagcuauu                                                   20


<210>  12256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12256
cuauaggaga cagcuauuca                                                   20


<210>  12257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12257
auaggagaca gcuauucauu                                                   20


<210>  12258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12258
uauagagaga gaggggugcc                                                   20


<210>  12259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12259
uucuuucacc uauuaaagcu                                                   20


<210>  12260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12260
acucuuaacc ccacuccgug                                                   20


<210>  12261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12261
uaaccccacu ccguguguau                                                   20


<210>  12262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12262
guguguaucu auguucuuga                                                   20


<210>  12263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12263
ugccaaggaa aucaagaaca                                                   20


<210>  12264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12264
ggaaauccug augacauguu                                                   20


<210>  12265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12265
cuaaaaugua uaaaaccaag                                                   20


<210>  12266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12266
ugucucccua aaauguauaa                                                   20


<210>  12267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12267
aguugucccc gccuuucugg                                                   20


<210>  12268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12268
cugccucaag uuguccccgc                                                   20


<210>  12269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12269
cccugccuca aguugucccc                                                   20


<210>  12270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12270
cucccugccu caaguugucc                                                   20


<210>  12271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12271
gauaagccuu uccaaaggag                                                   20


<210>  12272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12272
uuuggaaagg cuuaucggag                                                   20


<210>  12273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12273
ugccuguaau gccagcacuu                                                   20


<210>  12274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12274
caaagugcug gcauuacagg                                                   20


<210>  12275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12275
gccucccaaa gugcuggcau                                                   20


<210>  12276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12276
ggugauccac ccaccuccgc                                                   20


<210>  12277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12277
ugaccucagg ugauccaccc                                                   20


<210>  12278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12278
aacuccugac cucaggugau                                                   20


<210>  12279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12279
caaacuccug accucaggug                                                   20


<210>  12280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12280
acuaaaaaua caaaaaauua                                                   20


<210>  12281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12281
ggaggcugag gcaggagaau                                                   20


<210>  12282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12282
cgaguagcug ggauuacagg                                                   20


<210>  12283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12283
gccucccgag uagcugggau                                                   20


<210>  12284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12284
ugccucagcc ucccgaguag                                                   20


<210>  12285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12285
uccuucuggg uucaagcuau                                                   20


<210>  12286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12286
cugcaaccuc uuccuucugg                                                   20


<210>  12287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12287
gcucacugca accucuuccu                                                   20


<210>  12288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12288
agccugggca acaagaguga                                                   20


<210>  12289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12289
uguugcccag gcuggagugc                                                   20


<210>  12290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12290
aucucagaaa aaaaaaaaaa                                                   20


<210>  12291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12291
gaaaaaaaaa aaaaaggccu                                                   20


<210>  12292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12292
cgccuguaau cccagcacuu                                                   20


<210>  12293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12293
gcuucccaaa gugcugggau                                                   20


<210>  12294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12294
ugacuuugug accugcccgc                                                   20


<210>  12295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12295
aucuccugac uuugugaccu                                                   20


<210>  12296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12296
acuaaaaaau acaaaaaacu                                                   20


<210>  12297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12297
ccaccacacc cagcuaguuu                                                   20


<210>  12298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12298
gcaggcugag gcaggagaau                                                   20


<210>  12299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12299
gccugccgag uagcugggac                                                   20


<210>  12300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12300
ugccucagcc ugccgaguag                                                   20


<210>  12301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12301
ccgguucacg ccauucuccu                                                   20


<210>  12302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12302
gccuccccgg uucacgccau                                                   20


<210>  12303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12303
cugcaagcuc cgccuccccg                                                   20


<210>  12304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12304
gcucacugca agcuccgccu                                                   20


<210>  12305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12305
agcccggacg acagggcaag                                                   20


<210>  12306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12306
aucucaaauu aaaaaaaaaa                                                   20


<210>  12307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12307
aauuaaaaaa aaaaaaaaaa                                                   20


<210>  12308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12308
uuuuuuuuuu uuuuuuuuuu                                                   20


<210>  12309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12309
cuuuuuuuuu uuuuuuuuuu                                                   20


<210>  12310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12310
cucuuuuuuu uuuuuuuuuu                                                   20


<210>  12311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12311
cucucuuuuu uuuuuuuuuu                                                   20


<210>  12312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12312
gugagcagaa ggaugacuuu                                                   20


<210>  12313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12313
cugagauaga ugcauauucu                                                   20


<210>  12314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12314
cauuccauuc aaagucaucc                                                   20


<210>  12315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12315
agguauguuc cuuucacaua                                                   20


<210>  12316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12316
gccucccaag uagcugggac                                                   20


<210>  12317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12317
caaguagcug ggaccacaag                                                   20


<210>  12318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12318
cuaugugucc aggcuggucu                                                   20


<210>  12319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12319
gggguuuuag accagccugg                                                   20


<210>  12320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12320
aaugguccuc ccgccucagc                                                   20


<210>  12321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12321
cgccucagcc ucccgaaaug                                                   20


<210>  12322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12322
gccucccgaa augcugggau                                                   20


<210>  12323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12323
cgaaaugcug ggauuacagg                                                   20


<210>  12324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12324
ugccuguaau cccagcauuu                                                   20


<210>  12325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12325
ccaaaaccuc augguuuucc                                                   20


<210>  12326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12326
aaaaccucau gguuuucccu                                                   20


<210>  12327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12327
ugguuuuccc uguucucauc                                                   20


<210>  12328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12328
uccccugcac ccucccuucc                                                   20


<210>  12329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12329
cuuccccugg aguacucacc                                                   20


<210>  12330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12330
aggggaaggg agggugcagg                                                   20


<210>  12331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12331
ccuggccuug gaggucuggu                                                   20


<210>  12332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12332
aaggccaggu gaguacucca                                                   20


<210>  12333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12333
caccagaccu ccaaggccag                                                   20


<210>  12334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12334
ucacaugcug ugccuagaau                                                   20


<210>  12335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12335
ccucugcggc cugugcuuca                                                   20


<210>  12336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12336
gcggccugug cuucaccgcc                                                   20


<210>  12337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12337
cugucaaggc ggugaagcac                                                   20


<210>  12338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12338
cuucggcuca uucucgaagu                                                   20


<210>  12339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12339
uucucgaagu cucaaacuuc                                                   20


<210>  12340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12340
aagucucaaa cuucacuucu                                                   20


<210>  12341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12341
aacuucacuu cuccugugcg                                                   20


<210>  12342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12342
ugugcgcuga uucugaauuc                                                   20


<210>  12343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12343
ucugcuuggc guguuguuca                                                   20


<210>  12344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12344
gcagugcaca guggugauga                                                   20


<210>  12345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12345
ggaccucugc uuuaucauua                                                   20


<210>  12346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12346
gcuuuaucau uagaacagac                                                   20


<210>  12347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12347
ugcgguuucc cacgacauuc                                                   20


<210>  12348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12348
cuuggaagau gagccgugag                                                   20


<210>  12349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12349
ucuuccaagu gagaagugaa                                                   20


<210>  12350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12350
cggcucaucu uccaagugag                                                   20


<210>  12351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12351
agucaagcag aagcacagcc                                                   20


<210>  12352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12352
aaagcccacu uguuuccuua                                                   20


<210>  12353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12353
ggaaagaccu augucccagu                                                   20


<210>  12354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12354
uuaguaaaag guccgguugg                                                   20


<210>  12355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12355
uccccaggcc aggggagggg                                                   20


<210>  12356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12356
ccaggccagg ggaggggucc                                                   20


<210>  12357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12357
ccuggccugg ggaggaggau                                                   20


<210>  12358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12358
cugggguugg agccuuuagu                                                   20


<210>  12359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12359
aaccccaggg aggaccccuc                                                   20


<210>  12360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12360
gacccccuac uaaaggcucc                                                   20


<210>  12361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12361
cuuccuuugu agcacuuacu                                                   20


<210>  12362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12362
guggagaggg cucucuuuua                                                   20


<210>  12363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12363
acugagcacc ucccuuccuu                                                   20


<210>  12364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12364
ccacugagca ccucccuucc                                                   20


<210>  12365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12365
cuuuuaugua uuauauuucu                                                   20


<210>  12366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12366
uuuauguauu auauuucuuu                                                   20


<210>  12367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12367
ccaugaaaga aauauaauac                                                   20


<210>  12368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12368
gcugaucccu gauccauauc                                                   20


<210>  12369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12369
ggacugaaac accucugcug                                                   20


<210>  12370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12370
caagccacgc ugacuuucuu                                                   20


<210>  12371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12371
caacucccaa gccacgcuga                                                   20


<210>  12372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12372
agauaucuua agacuagugg                                                   20


<210>  12373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12373
acuagucuua agauaucuug                                                   20


<210>  12374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12374
gggcugccug guucuuguag                                                   20


<210>  12375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12375
gucguccuac aagaaccagg                                                   20


<210>  12376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12376
gcauacugca cccccagggg                                                   20


<210>  12377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12377
gaacagugca aaugucaguc                                                   20


<210>  12378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12378
gccacugaca gauagacuga                                                   20


<210>  12379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12379
aaggcuggcu cugccacuga                                                   20


<210>  12380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12380
uugcaccccu gcuccaaggc                                                   20


<210>  12381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12381
gcacuggcca ggcaugcaga                                                   20


<210>  12382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12382
ucuagauggg gccuucuguc                                                   20


<210>  12383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12383
gucucaucua gauggggccu                                                   20


<210>  12384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12384
uggcagcuca aacggccugg                                                   20


<210>  12385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12385
aacggccugg cagaugcuug                                                   20


<210>  12386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12386
aagcaucugc caggccguuu                                                   20


<210>  12387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12387
ccaagcaucu gccaggccgu                                                   20


<210>  12388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12388
cuccaagcau cugccaggcc                                                   20


<210>  12389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12389
agaagccccc ucucuccaag                                                   20


<210>  12390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12390
ucccagaaau ggugcugucu                                                   20


<210>  12391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12391
cuucccagaa auggugcugu                                                   20


<210>  12392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12392
caggugacuc ucuucccaga                                                   20


<210>  12393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12393
ucccucccag gugacucucu                                                   20


<210>  12394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12394
ggcuuggagg ugaagagagg                                                   20


<210>  12395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12395
aagccggagc guggccucau                                                   20


<210>  12396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12396
ucaccuccaa gccggagcgu                                                   20


<210>  12397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12397
cuucaccucc aagccggagc                                                   20


<210>  12398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12398
aauucuuucu ugcagcagcc                                                   20


<210>  12399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12399
uggccucaag caaucuuccc                                                   20


<210>  12400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12400
agcaaucuuc ccaccucagc                                                   20


<210>  12401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12401
gccuccccaa gcgcugggau                                                   20


<210>  12402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12402
ccaagcgcug ggauuauaga                                                   20


<210>  12403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12403
ugucuauaau cccagcgcuu                                                   20


<210>  12404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12404
auaaaaucau cuuuuauugg                                                   20


<210>  12405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12405
guggcaggaa cugggugcag                                                   20


<210>  12406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12406
uaaaauccug agaacuuccu                                                   20


<210>  12407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12407
ggauuuuagg agcucugugg                                                   20


<210>  12408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12408
cccaggaagu ucucaggauu                                                   20


<210>  12409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12409
uuagaacaaa agaugcucac                                                   20


<210>  12410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12410
ugguggcucc uggauaggag                                                   20


<210>  12411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12411
uggauaggag ugaaucacca                                                   20


<210>  12412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12412
uauccaggag ccaccaagag                                                   20


<210>  12413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12413
ggcuugaucu uucuggugau                                                   20


<210>  12414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12414
aaaaaaaaaa aaaaaacuuu                                                   20


<210>  12415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12415
aucucaaaaa aaaaaaaaaa                                                   20


<210>  12416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12416
cucuguugcc caggcuggag                                                   20


<210>  12417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12417
guugcccagg cuggagugca                                                   20


<210>  12418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12418
agccugggca acagagugag                                                   20


<210>  12419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12419
gcucacuaca agcucugccu                                                   20


<210>  12420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12420
cuacaagcuc ugccucccag                                                   20


<210>  12421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12421
gccucccagg uucaagugau                                                   20


<210>  12422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12422
cagguucaag ugauucuccu                                                   20


<210>  12423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12423
ugccucagcc uccugagcag                                                   20


<210>  12424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12424
gccuccugag caguugggac                                                   20


<210>  12425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12425
ugagcaguug ggacuacagg                                                   20


<210>  12426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12426
ggaggcugag gcaggagaau                                                   20


<210>  12427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12427
gcuaaaaaua caaaaauuag                                                   20


<210>  12428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12428
aacuccuuac cuugugaucc                                                   20


<210>  12429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12429
uuaccuugug auccgccugc                                                   20


<210>  12430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12430
gccucccaaa gugcugggau                                                   20


<210>  12431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12431
caaagugcug ggauuacagg                                                   20


<210>  12432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12432
ugccuguaau cccagcacuu                                                   20


<210>  12433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12433
ccuugaaauu aauuuuugug                                                   20


<210>  12434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12434
uuacaugauu uuucuccccu                                                   20


<210>  12435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12435
cuuuacauga uuuuucuccc                                                   20


<210>  12436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12436
ugaaaauauc cuauuuaggc                                                   20


<210>  12437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12437
aacaaucuga caugggaaug                                                   20


<210>  12438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12438
aaggugugcu aacauuccca                                                   20


<210>  12439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12439
cuaaggugug cuaacauucc                                                   20


<210>  12440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12440
agaaaaacaa aacuucccaa                                                   20


<210>  12441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12441
uuuaugaaua caaaacccuu                                                   20


<210>  12442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12442
uucuuuagca ugauaaaaua                                                   20


<210>  12443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12443
agcgugugcc cuuaucgggu                                                   20


<210>  12444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12444
uauuccuaau uuuaacauua                                                   20


<210>  12445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12445
aaaaaaaaaa agaagaaaga                                                   20


<210>  12446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12446
gucucaaaaa aaaaaaagaa                                                   20


<210>  12447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12447
guugccaggc uggagugcag                                                   20


<210>  12448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12448
agccuggcaa cagagcaaga                                                   20


<210>  12449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12449
cugcacgccc cccgccuccc                                                   20


<210>  12450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12450
cagguucaag cgauucuccu                                                   20


<210>  12451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12451
ugccucagcc ucccgaguag                                                   20


<210>  12452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12452
gccucccgag uagcugggac                                                   20


<210>  12453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12453
cgaguagcug ggacuacagg                                                   20


<210>  12454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12454
ggaggcugag gcaggagaau                                                   20


<210>  12455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12455
acuaaaauac aaaaaaaaau                                                   20


<210>  12456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12456
caaccucacg uacugggauu                                                   20


<210>  12457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12457
cguacuggga uuaccggugu                                                   20


<210>  12458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12458
caccgguaau cccaguacgu                                                   20


<210>  12459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12459
agauaaaucc auaauaaguu                                                   20


<210>  12460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12460
gcuaugaugu uugguagguu                                                   20


<210>  12461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12461
gacacugacg ucagccuaca                                                   20


<210>  12462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12462
gcaguagacu gugcugcugu                                                   20


<210>  12463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12463
caggcagcca cgcagucaca                                                   20


<210>  12464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12464
ugaaaauaaa gaugguccca                                                   20


<210>  12465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12465
guuaauguuu auguuugucu                                                   20


<210>  12466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12466
ucuggcuucc agccccgaaa                                                   20


<210>  12467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12467
cacccucuuc uggcuuccag                                                   20


<210>  12468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12468
gcgcucccac ccucuucugg                                                   20


<210>  12469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12469
cugcgcuccc acccucuucu                                                   20


<210>  12470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12470
cucugcgcuc ccacccucuu                                                   20


<210>  12471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12471
cucucugcgc ucccacccuc                                                   20


<210>  12472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12472
gccuuccaga uaccuugucc                                                   20


<210>  12473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12473
uuuuuuuuug agguggcguc                                                   20


<210>  12474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12474
aaaaaaaagg aggcuuagcu                                                   20


<210>  12475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12475
cucuguugcc aggcuggagu                                                   20


<210>  12476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12476
guugccaggc uggagugcaa                                                   20


<210>  12477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12477
agccuggcaa cagagugaga                                                   20


<210>  12478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12478
gcucacugca accuccaccu                                                   20


<210>  12479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12479
cugcaaccuc caccucccug                                                   20


<210>  12480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12480
accucccugg uucaagcgau                                                   20


<210>  12481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12481
cugguucaag cgauucuccu                                                   20


<210>  12482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12482
ugccucagcc ucccgaguag                                                   20


<210>  12483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12483
gccucccgag uagcugggau                                                   20


<210>  12484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12484
cgaguagcug ggauuacagg                                                   20


<210>  12485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12485
ggaggcugag gcaggagaau                                                   20


<210>  12486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12486
cgccacuaca cccagcugau                                                   20


<210>  12487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12487
acuaaaauua caaaaaucag                                                   20


<210>  12488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12488
aucucuugac gucaugaucu                                                   20


<210>  12489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12489
ugacgucaug aucuguccac                                                   20


<210>  12490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12490
gccucccaaa gugcugggau                                                   20


<210>  12491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12491
caaagugcug ggauuauagg                                                   20


<210>  12492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12492
gacggggcac ggugggucac                                                   20


<210>  12493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12493
ugagcauagg ggacuaaaaa                                                   20


<210>  12494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12494
agaggcuuag cucagacggg                                                   20


<210>  12495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12495
gaaauaugga ugguccucug                                                   20


<210>  12496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12496
gggaccauac caaucccuuc                                                   20


<210>  12497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12497
aaacuggaac uuggauuaag                                                   20


<210>  12498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12498
ugggacacua gaaguccuag                                                   20


<210>  12499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12499
ccggaagaag auaauaccuu                                                   20


<210>  12500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12500
ggaagaagau aauaccuuaa                                                   20


<210>  12501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12501
cuaauaaauu ucaaauacaa                                                   20


<210>  12502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12502
aauaaauuuc aaauacaaug                                                   20


<210>  12503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12503
uaucacguuc cugguaauuu                                                   20


<210>  12504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12504
ugccugaagu uucugcuaau                                                   20


<210>  12505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12505
gaggccuaga aucuaucuag                                                   20


<210>  12506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12506
gaggguaugu uucucaugcc                                                   20


<210>  12507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12507
auuaucuaga cacuagauag                                                   20


<210>  12508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12508
uugaacaugg gaaacauagu                                                   20


<210>  12509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12509
aaaguaugcu guugucacau                                                   20


<210>  12510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12510
ggcuauuucu auucugcugu                                                   20


<210>  12511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12511
cuggcuauuu cuauucugcu                                                   20


<210>  12512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12512
gugccuuauu cuggguagug                                                   20


<210>  12513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12513
cagugccuua uucuggguag                                                   20


<210>  12514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12514
ccauauccuu ucuucugcau                                                   20


<210>  12515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12515
caccauaucc uuucuucugc                                                   20


<210>  12516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12516
aaauaaaugu auauuagauc                                                   20


<210>  12517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12517
cugguacucc aaauaaaugu                                                   20


<210>  12518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12518
cccugguacu ccaaauaaau                                                   20


<210>  12519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12519
cucccuggua cuccaaauaa                                                   20


<210>  12520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12520
cucucccugg uacuccaaau                                                   20


<210>  12521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12521
uucucucucu cccugguacu                                                   20


<210>  12522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12522
gucaccgucc uugaaacacg                                                   20


<210>  12523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12523
cagucaccgu ccuugaaaca                                                   20


<210>  12524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12524
uuggaauuca cugggcuuug                                                   20


<210>  12525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12525
gaggcagagg guuaucagaa                                                   20


<210>  12526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12526
gagugucccc auuaaaugca                                                   20


<210>  12527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12527
gccucugagu guccccauua                                                   20


<210>  12528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12528
uucugauaac ccucugccuc                                                   20


<210>  12529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12529
cccaaguucu caucauccca                                                   20


<210>  12530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12530
caaguucuca ucaucccagg                                                   20


<210>  12531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12531
ucaucccagg gccagggaca                                                   20


<210>  12532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12532
cuaaggugug accagcuguc                                                   20


<210>  12533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12533
uagugaacuc ccuaaggugu                                                   20


<210>  12534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12534
ccuagugaac ucccuaaggu                                                   20


<210>  12535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12535
guucccuucc aauuucccua                                                   20


<210>  12536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12536
cgguucccuu ccaauuuccc                                                   20


<210>  12537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12537
cauugcuaug cgauuggcua                                                   20


<210>  12538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12538
gugaaagauu ucuaagguca                                                   20


<210>  12539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12539
agaaguucug gaacgcagau                                                   20


<210>  12540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12540
aagccuuacc uauaccagcu                                                   20


<210>  12541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12541
guaggaaagc ucaaagccuu                                                   20


<210>  12542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12542
agggccaucu ggccaacaag                                                   20


<210>  12543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12543
agguccccuu ugguaaccua                                                   20


<210>  12544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12544
ccuuacaccc ccagacguau                                                   20


<210>  12545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12545
uuacaccccc agacguauca                                                   20


<210>  12546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12546
gucuuugguu uucuguaguu                                                   20


<210>  12547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12547
acagcaagaa ugaaaagugg                                                   20


<210>  12548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12548
ggccuguaau cccagcacuu                                                   20


<210>  12549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12549
caaagugcug ggauuacagg                                                   20


<210>  12550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12550
gccucccaaa gugcugggau                                                   20


<210>  12551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12551
ugauccaccc gccucggccu                                                   20


<210>  12552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12552
ugaccucgug auccacccgc                                                   20


<210>  12553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12553
acuaaaaaua caaaaaaauu                                                   20


<210>  12554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12554
ggaggcugag gcaggagaau                                                   20


<210>  12555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12555
cgaguagcug ggacuacagg                                                   20


<210>  12556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12556
gccucccgag uagcugggac                                                   20


<210>  12557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12557
ugccucagcc ucccgaguag                                                   20


<210>  12558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12558
cggguucacg ccauucuccu                                                   20


<210>  12559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12559
gccucccggg uucacgccau                                                   20


<210>  12560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12560
cugcaagcuc cgccucccgg                                                   20


<210>  12561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12561
gcucacugca agcuccgccu                                                   20


<210>  12562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12562
agccugggug acagagcaag                                                   20


<210>  12563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12563
gucacccagg cuggagugca                                                   20


<210>  12564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12564
gucucaaaaa aaaaaaaaaa                                                   20


<210>  12565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12565
aaaaaaaaaa aaaaaaaaaa                                                   20


<210>  12566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12566
ugaaaggaag caacugccgc                                                   20


<210>  12567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12567
ggggucauuu ucuucugccu                                                   20


<210>  12568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12568
gaucuuccuc uggggucauu                                                   20


<210>  12569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12569
auuucuuucc ugaaucucug                                                   20


<210>  12570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12570
ccauuucuuu ccugaaucuc                                                   20


<210>  12571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12571
acaacuguug ugucucuauc                                                   20


<210>  12572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12572
aucuuuugua acauauaugu                                                   20


<210>  12573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12573
cucugucgcc caggcuacag                                                   20


<210>  12574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12574
gucgcccagg cuacagugaa                                                   20


<210>  12575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12575
gcucacugca accucugccc                                                   20


<210>  12576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12576
cugcaaccuc ugccccuugg                                                   20


<210>  12577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12577
gccccuuggg cucaaaugau                                                   20


<210>  12578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12578
aaugauucuc uugccucagc                                                   20


<210>  12579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12579
ugccucagcc uccugaguag                                                   20


<210>  12580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12580
gccuccugag uagcugagau                                                   20


<210>  12581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12581
ugaguagcug agauuacagg                                                   20


<210>  12582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12582
ggaggcugag gcaagagaau                                                   20


<210>  12583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12583
gcuacucagg aggcugaggc                                                   20


<210>  12584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12584
aguaaaaaua caaaaauuag                                                   20


<210>  12585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12585
auguuggcca ggcuggucuu                                                   20


<210>  12586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12586
ggugauccac cugccugggc                                                   20


<210>  12587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12587
caaagugcua ggauuacagg                                                   20


<210>  12588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12588
cgccuguaau ccuagcacuu                                                   20


<210>  12589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12589
aaauugggag aaaccaaaaa                                                   20


<210>  12590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12590
caauuuggag gguauuauug                                                   20


<210>  12591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12591
cugcauaauc aagaagagaa                                                   20


<210>  12592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12592
ucuugauuau gcagggagcu                                                   20


<210>  12593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12593
agguaucaaa aucuaacgua                                                   20


<210>  12594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12594
uuucaugguc acccuagaaa                                                   20


<210>  12595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12595
ucuuuucaug gucacccuag                                                   20


<210>  12596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12596
aaaaaaaaaa aacauacacc                                                   20


<210>  12597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12597
aucucaaaaa aaaaaaaaca                                                   20


<210>  12598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12598
cuuugucacc caggcuggag                                                   20


<210>  12599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12599
agccugggug acaaagugag                                                   20


<210>  12600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12600
cugcaaccuc cuccucuugg                                                   20


<210>  12601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12601
uccucuuggg uucaggccau                                                   20


<210>  12602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12602
ucuuggguuc aggccauccu                                                   20


<210>  12603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12603
uggguucagg ccauccuccc                                                   20


<210>  12604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12604
caccuaggcc uccagaguag                                                   20


<210>  12605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12605
agaguaggug ggaucacagg                                                   20


<210>  12606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12606
ggaggccuag gugggaggau                                                   20


<210>  12607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12607
acuaaauauu uaaaaaaaaa                                                   20


<210>  12608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12608
ugaccucagg cgaucugccu                                                   20


<210>  12609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12609
ggcgaucugc cuaccucugc                                                   20


<210>  12610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12610
gccucucaaa gugcugggau                                                   20


<210>  12611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12611
caaagugcug ggauuacagg                                                   20


<210>  12612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12612
aagugcuggg auuacaggug                                                   20


<210>  12613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12613
caccuguaau cccagcacuu                                                   20


<210>  12614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12614
guuaguuuga aagugaucac                                                   20


<210>  12615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12615
guuaccuggu uuuugguuaa                                                   20


<210>  12616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12616
cguauaucaa cgauuacagu                                                   20


<210>  12617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12617
aguuuaaaaa cgaggguugu                                                   20


<210>  12618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12618
uuuuuaaacu agagcauuuc                                                   20


<210>  12619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12619
uuaccagcgg ugcaccuaga                                                   20


<210>  12620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12620
uucaucuguc cuguuuccuu                                                   20


<210>  12621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12621
gccauccuau gagacgggaa                                                   20


<210>  12622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12622
uaggauggcu gaggcgcagg                                                   20


<210>  12623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12623
uuaccagcuc cuggcuuucu                                                   20


<210>  12624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12624
uggcuuucuu cucuggaagg                                                   20


<210>  12625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12625
ggaagguucc ugccuguuuu                                                   20


<210>  12626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12626
caccugcucc ucucucagcc                                                   20


<210>  12627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12627
ucucucagcc cucucagggg                                                   20


<210>  12628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12628
cucagcccuc ucaggggugg                                                   20


<210>  12629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12629
cagcccucuc aggggugggg                                                   20


<210>  12630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12630
gcccucucag ggguggggcu                                                   20


<210>  12631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12631
cagggguggg gcuggaggcc                                                   20


<210>  12632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12632
gggguggggc uggaggccac                                                   20


<210>  12633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12633
agccccaccc cugagagggc                                                   20


<210>  12634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12634
uugguggccu ccagccccac                                                   20


<210>  12635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12635
ucugcucucc aguugcucga                                                   20


<210>  12636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12636
gcucuccagu ugcucgacug                                                   20


<210>  12637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12637
ccaguugcuc gacugcuccu                                                   20


<210>  12638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12638
aguugcucga cugcuccuca                                                   20


<210>  12639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12639
acugcuccuc auuucccccu                                                   20


<210>  12640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12640
ucauuucccc cuggggucug                                                   20


<210>  12641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12641
uuucccccug gggucugcgu                                                   20


<210>  12642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12642
ggucggggcu gcucccgcuu                                                   20


<210>  12643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12643
cgcuuacugc ccccugccca                                                   20


<210>  12644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12644
ggcugcuuuc aaggccucuu                                                   20


<210>  12645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12645
ucucucuucu cggcaggaca                                                   20


<210>  12646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12646
cuucucggca ggacaggcac                                                   20


<210>  12647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12647
ucucggcagg acaggcacag                                                   20


<210>  12648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12648
gcaggacagg cacaggcagg                                                   20


<210>  12649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12649
ccgcccagug agauucuuuc                                                   20


<210>  12650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12650
cugggcgggg agcuaagcau                                                   20


<210>  12651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12651
auuccccugc ccagagagag                                                   20


<210>  12652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12652
gggcagggga auugagggcg                                                   20


<210>  12653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12653
cugggcaggg gaauugaggg                                                   20


<210>  12654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12654
cucugggcag gggaauugag                                                   20


<210>  12655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12655
cucgcucuuu uuuuuuuuuu                                                   20


<210>  12656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12656
cgcucuuuuu uuuuuuuuug                                                   20


<210>  12657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12657
cucuuuuuuu uuuuuuugag                                                   20


<210>  12658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12658
uuuuuuuuuu uuugagacag                                                   20


<210>  12659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12659
aaaaaaaaaa aaagagcgag                                                   20


<210>  12660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12660
gucucaaaaa aaaaaaaaag                                                   20


<210>  12661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12661
gucacccagg cuggagugca                                                   20


<210>  12662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12662
agccugggug acagagcaag                                                   20


<210>  12663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12663
aucucagcuc acugcaaccu                                                   20


<210>  12664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12664
gcucacugca accuccgccu                                                   20


<210>  12665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12665
cugcaaccuc cgccuccugg                                                   20


<210>  12666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12666
gccuccuggg uucaagcgau                                                   20


<210>  12667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12667
uggguucaag cgauucuccu                                                   20


<210>  12668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12668
ugccucagcc ucuugaguag                                                   20


<210>  12669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12669
gccucuugag uagcugggau                                                   20


<210>  12670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12670
ugaguagcug ggauuacagg                                                   20


<210>  12671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12671
agaggcugag gcaggagaau                                                   20


<210>  12672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12672
acuaaaaaua caaaaauuag                                                   20


<210>  12673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12673
caacuaaaaa uacaaaaauu                                                   20


<210>  12674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12674
cucaacuaaa aauacaaaaa                                                   20


<210>  12675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12675
ugaccucagg ugaucagccc                                                   20


<210>  12676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12676
ggugaucagc ccaccucggc                                                   20


<210>  12677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12677
gccucccaaa gugcugggau                                                   20


<210>  12678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12678
caaagugcug ggauuacagg                                                   20


<210>  12679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12679
caccuguaau cccagcacuu                                                   20


<210>  12680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12680
cuucugugua uguguacgcu                                                   20


<210>  12681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12681
ucuguguaug uguacgcugu                                                   20


<210>  12682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12682
acauggugug uagucggcua                                                   20


<210>  12683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12683
ucuggaacag gauucuaaug                                                   20


<210>  12684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12684
gcuccuucug cccagcaucu                                                   20


<210>  12685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12685
uucugcccag caucuaucuu                                                   20


<210>  12686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12686
gagacaccau gccagacugc                                                   20


<210>  12687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12687
gaggccuaaa aaugggcaca                                                   20


<210>  12688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12688
uuuuagauga ugccaaacuu                                                   20


<210>  12689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12689
gccauggcug aagcaguugu                                                   20


<210>  12690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12690
cuggaugggu uggaauaauu                                                   20


<210>  12691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12691
caaaccaaau uauuccaacc                                                   20


<210>  12692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12692
aggucauucu guuauaugcu                                                   20


<210>  12693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12693
gacggaagug uauuucuccc                                                   20


<210>  12694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12694
cuuacagaug aaagaauucc                                                   20


<210>  12695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12695
uuccagcucc caucacccca                                                   20


<210>  12696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12696
caucacccca ggauguggcu                                                   20


<210>  12697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12697
agucccagcc aacacauccc                                                   20


<210>  12698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12698
cuggaauggg auguguuggc                                                   20


<210>  12699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12699
uuacuucugc uugcaucucc                                                   20


<210>  12700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12700
cuggcuagca cuuacuuagu                                                   20


<210>  12701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12701
uagcuagugu augacagucc                                                   20


<210>  12702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12702
aaagaagguc agagcggcug                                                   20


<210>  12703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12703
gaccuucuuu agagaccuuu                                                   20


<210>  12704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12704
auuacuuauu guuaugggac                                                   20


<210>  12705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12705
uucagguuga uguccuaagc                                                   20


<210>  12706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12706
gaaugggauu guauuuggag                                                   20


<210>  12707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12707
aaauacaauc ccauucugag                                                   20


<210>  12708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12708
uuaaagaacc ugucuccaaa                                                   20


<210>  12709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12709
uuaccuccuu aaagaaccug                                                   20


<210>  12710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12710
uuuuagccuc cuuaccuccu                                                   20


<210>  12711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12711
ucuuguaaga caucagucgg                                                   20


<210>  12712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12712
gagggacggc cacgugagga                                                   20


<210>  12713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12713
gagcaugucc guguccuaau                                                   20


<210>  12714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12714
cguggccguc ccucugagca                                                   20


<210>  12715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12715
ggggaaacca accuugccaa                                                   20


<210>  12716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12716
gacuucuagc cucuaggacc                                                   20


<210>  12717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12717
aggaccauga gaagauacau                                                   20


<210>  12718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12718
ugguccuaga ggcuagaagu                                                   20


<210>  12719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12719
augacuagac augugugcug                                                   20


<210>  12720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12720
acacguaacu acauauaacu                                                   20


<210>  12721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12721
acuucucgcc aggguucagu                                                   20


<210>  12722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12722
ccaggguuca gucaaauacc                                                   20


<210>  12723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12723
caccugagag cucagccggg                                                   20


<210>  12724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12724
ggugggaggc agcugguauu                                                   20


<210>  12725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12725
caggugggag gcagcuggua                                                   20


<210>  12726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12726
gccggggaag ggucccuuuc                                                   20


<210>  12727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12727
cgugguguug gcaggaucca                                                   20


<210>  12728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12728
uggccugcug gacugagaac                                                   20


<210>  12729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12729
guccagcagg ccaugaggaa                                                   20


<210>  12730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12730
guucucacug ccuguuggcc                                                   20


<210>  12731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12731
cugccuguug gccagaggcc                                                   20


<210>  12732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12732
ggccaacagg cagugagaac                                                   20


<210>  12733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12733
ccaugugggc cucuccaaca                                                   20


<210>  12734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12734
ccaacauggc agcugacuuc                                                   20


<210>  12735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12735
aacauggcag cugacuucau                                                   20


<210>  12736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12736
gaugaaguca gcugccaugu                                                   20


<210>  12737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12737
guugccuucu uggcauggau                                                   20


<210>  12738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12738
cuguugccuu cuuggcaugg                                                   20


<210>  12739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12739
cuggcccucu cuguugccuu                                                   20


<210>  12740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12740
cggggagggg ucauacaagg                                                   20


<210>  12741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12741
ccgugagcuu gggcuguacc                                                   20


<210>  12742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12742
ugguauugac acccuuguau                                                   20


<210>  12743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12743
ccuccuggua uugacacccu                                                   20


<210>  12744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12744
uaagauggcc ccagcacccc                                                   20


<210>  12745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12745
gugggcagac ucauaagaug                                                   20


<210>  12746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12746
agguuguuag uuaccucagu                                                   20


<210>  12747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12747
gcuguuaaua agggccuuug                                                   20


<210>  12748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12748
aaaauaaaua aauaaauaaa                                                   20


<210>  12749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12749
gucucaaaaa uaaauaaaua                                                   20


<210>  12750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12750
cucuugucac ccaggcugga                                                   20


<210>  12751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12751
ugucacccag gcuggagugc                                                   20


<210>  12752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12752
agccugggug acaagaguga                                                   20


<210>  12753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12753
cugcaaccuc caccucccag                                                   20


<210>  12754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12754
accucccagg uucaagcaau                                                   20


<210>  12755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12755
cagguucaag caauucugcc                                                   20


<210>  12756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12756
gccuccggaa uagcugggac                                                   20


<210>  12757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12757
ggaauagcug ggacuacagg                                                   20


<210>  12758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12758
acuaaaaaua caaaaauuag                                                   20


<210>  12759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12759
aacuccugac cucuggugau                                                   20


<210>  12760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12760
ugaccucugg ugaucugccu                                                   20


<210>  12761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12761
ggugaucugc cugccuuggc                                                   20


<210>  12762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12762
caaagugcug ggauuacagg                                                   20


<210>  12763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12763
cgccuguaau cccagcacuu                                                   20


<210>  12764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12764
cuggaacuua auuuuuuuag                                                   20


<210>  12765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12765
aaaaaaauua aguuccagcg                                                   20


<210>  12766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12766
aucacccaag cuggagugca                                                   20


<210>  12767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12767
agcuugggug auagagcgac                                                   20


<210>  12768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12768
cuugcagccu caaauuccug                                                   20


<210>  12769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12769
aauuccuggg uucaggugau                                                   20


<210>  12770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12770
cacaucagcc ucccaagaac                                                   20


<210>  12771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12771
caagaacugg gaacuaacag                                                   20


<210>  12772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12772
gcuguccuuc ucaagaaaag                                                   20


<210>  12773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12773
agaaaaggga ggcuacugcu                                                   20


<210>  12774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12774
cuuuucuuga gaaggacagc                                                   20


<210>  12775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12775
gagacaaggc ggaggugcug                                                   20


<210>  12776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12776
gagccugucc uaaagggaaa                                                   20


<210>  12777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12777
gccuugucuc agagccuguc                                                   20


<210>  12778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12778
guggccacaa acagcaccuc                                                   20


<210>  12779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12779
ggguugcagg uguggccugg                                                   20


<210>  12780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12780
ucucugccug caucaccccc                                                   20


<210>  12781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12781
cugccugcau caccccccgg                                                   20


<210>  12782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12782
gccugcauca ccccccggcu                                                   20


<210>  12783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12783
gaggccaacc uuacucccug                                                   20


<210>  12784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12784
gagacaaccg cccagccggg                                                   20


<210>  12785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12785
cugcugggca ggcuggacag                                                   20


<210>  12786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12786
ccguuugccc cucuaccacc                                                   20


<210>  12787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12787
guuugccccu cuaccaccca                                                   20


<210>  12788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12788
accacccaaa aggcaggagg                                                   20


<210>  12789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12789
ugccuuuugg gugguagagg                                                   20


<210>  12790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12790
ggagaccagg acccugcccg                                                   20


<210>  12791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12791
agagccuccu gccuuuuggg                                                   20


<210>  12792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12792
cgccugggac acaggccgug                                                   20


<210>  12793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12793
gcugagcugc ugcugaauga                                                   20


<210>  12794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12794
gcagaggucu guggggcacc                                                   20


<210>  12795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12795
gaccuuccgg caggaccccc                                                   20


<210>  12796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12796
cauaaagaaa cgcccccagg                                                   20


<210>  12797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12797
uuccuguggg cggcaucuug                                                   20


<210>  12798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12798
cugcacuaau cacagugccu                                                   20


<210>  12799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12799
gugggcagca ggcgcugacc                                                   20


<210>  12800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12800
ccucccuucc ggggcgcugc                                                   20


<210>  12801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12801
ucccuuccgg ggcgcugcgc                                                   20


<210>  12802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12802
cuuccggggc gcugcgcugg                                                   20


<210>  12803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12803
ccagcucacu gggggugggg                                                   20


<210>  12804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12804
agcucacugg ggguggggug                                                   20


<210>  12805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12805
cugggggugg gguggggguc                                                   20


<210>  12806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12806
ggucgugccg accacgcgca                                                   20


<210>  12807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12807
gcgcucugcg caggagcucg                                                   20


<210>  12808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12808
gcgcaggagc ucgcccaccc                                                   20


<210>  12809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12809
ugcgcagagc gcagagaaug                                                   20


<210>  12810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12810
cccacccucu ccccgugcag                                                   20


<210>  12811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12811
ccccgugcag agagccccgc                                                   20


<210>  12812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12812
ccgugcagag agccccgcag                                                   20


<210>  12813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12813
gcacggggag agggugggcg                                                   20


<210>  12814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12814
cugcacgggg agaggguggg                                                   20


<210>  12815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12815
ccgcagggcu guccggguga                                                   20


<210>  12816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12816
cccggacagc ccugcgggga                                                   20


<210>  12817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12817
ggccacgggc caguguggcg                                                   20


<210>  12818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12818
cgccacacug gcccguggcc                                                   20


<210>  12819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12819
gcucagaguc cacggccggc                                                   20


<210>  12820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12820
gaguccacgg ccggcugucg                                                   20


<210>  12821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12821
gagccgaggu ggccuugggg                                                   20


<210>  12822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12822
aggcgucggc gggggauccu                                                   20


<210>  12823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12823
gcgcccccuc cacggccccg                                                   20


<210>  12824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12824
acggccccgc cccguccaug                                                   20


<210>  12825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12825
cccaugaagg acggggccau                                                   20


<210>  12826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12826
auggcccugc cccuccgcgc                                                   20


<210>  12827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12827
gcgccccacc ccucccucgc                                                   20


<210>  12828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12828
cucgccccac cucucaccuu                                                   20


<210>  12829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12829
ccccaccucu caccuuccug                                                   20


<210>  12830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12830
caccuuccug ccccgccccc                                                   20


<210>  12831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12831
ccuuccugcc ccgcccccag                                                   20


<210>  12832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12832
ccaccccuca ccggccaguc                                                   20


<210>  12833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12833
ccggccaguc cccuccccua                                                   20


<210>  12834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12834
ccuaucccgc uccgccccuc                                                   20


<210>  12835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12835
gccccucagc cgccccgccc                                                   20


<210>  12836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12836
gccgccccgc cccucagccg                                                   20


<210>  12837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12837
gccggccugc cuaauguccc                                                   20


<210>  12838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12838
ccccgccccu caggcggccu                                                   20


<210>  12839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12839
ggcggccucc cugcugugcc                                                   20


<210>  12840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12840
cugcugugcc ccgccccggc                                                   20


<210>  12841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12841
ccacgccccu accucaccac                                                   20


<210>  12842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12842
ccacgccccc cgcaucgcca                                                   20


<210>  12843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12843
cuuaccaugc agucccgccc                                                   20


<210>  12844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12844
ucccgccucg ccgcgacacu                                                   20


<210>  12845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12845
ccgcgacacu ucacacacag                                                   20


<210>  12846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12846
ccccauuaca gucucaccac                                                   20


<210>  12847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12847
ccacgccccg uccccucucc                                                   20


<210>  12848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12848
ccguugagcc ccgcgccuuc                                                   20


<210>  12849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12849
guugagcccc gcgccuucgc                                                   20


<210>  12850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12850
acggagaggg gacggggcgu                                                   20


<210>  12851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12851
cacagcaagg ccgcugacag                                                   20


<210>  12852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12852
gccaauggcu ggccagggaa                                                   20


<210>  12853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12853
gccggcgcgg ccccgccucc                                                   20


<210>  12854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12854
gccggcgcag cgucugggac                                                   20


<210>  12855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12855
gguucugcuu uuaccugcgg                                                   20


<210>  12856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12856
gggccgcagg uaaaagcaga                                                   20


<210>  12857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12857
gcaccggggc aaugaauggg                                                   20


<210>  12858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12858
cggcgccgcu cagcaccggg                                                   20


<210>  12859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12859
ggccgacucg cggcgccgcu                                                   20


<210>  12860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12860
ggggacugcc gugccgggcg                                                   20


<210>  12861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12861
cgcccggcac ggcagucccc                                                   20


<210>  12862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12862
aaggccuuca ucagcuuuuc                                                   20


<210>  12863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12863
aguccuucca gcagcagcag                                                   20


<210>  12864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12864
ucagcuuccu cagccgccgc                                                   20


<210>  12865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12865
gcuuccucag ccgccgccgc                                                   20


<210>  12866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12866
gccgccgccg caggcacagc                                                   20


<210>  12867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12867
gccgcagccg cccccgccgc                                                   20


<210>  12868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12868
gccacagccg ggccgggugg                                                   20


<210>  12869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12869
ucagccacag ccgggccggg                                                   20


<210>  12870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12870
cggucggugc agcggcuccu                                                   20


<210>  12871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12871
cugucccggc gggucccagg                                                   20


<210>  12872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12872
gcggggccgg ggguucgugu                                                   20


<210>  12873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12873
gucucugcgg ggccgggggu                                                   20


<210>  12874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12874
ggguugcugg gucacucugu                                                   20


<210>  12875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12875
ugggcucugg guugcugggu                                                   20


<210>  12876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12876
uggggcgagg ccuuccccca                                                   20


<210>  12877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12877
ccccaggagg gggcgggugu                                                   20


<210>  12878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12878
cucacuuggg ucuucccuug                                                   20


<210>  12879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12879
cuugggucuu cccuuguccu                                                   20


<210>  12880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12880
cgcgagggga ggcagagccu                                                   20


<210>  12881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12881
cgaggggagg cagagccuug                                                   20


<210>  12882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12882
cgagaggaca agggaagacc                                                   20


<210>  12883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12883
ccucgcgaga ggacaaggga                                                   20


<210>  12884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12884
gccuccccuc gcgagaggac                                                   20


<210>  12885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12885
gugaauucag gacaggcccc                                                   20


<210>  12886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12886
ccucggugaa uucaggacag                                                   20


<210>  12887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12887
gcccucucgc ccuucgcagg                                                   20


<210>  12888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12888
cgcccuucgc aggaugcgaa                                                   20


<210>  12889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12889
cccuucgcag gaugcgaaga                                                   20


<210>  12890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12890
ucgcauccug cgaagggcga                                                   20


<210>  12891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12891
ccccaacucu ucgcauccug                                                   20


<210>  12892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12892
caaauaaaaa gaaacaaguu                                                   20


<210>  12893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12893
ucacaacgca guuaaaagaa                                                   20


<210>  12894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12894
aaguucucuu cacaacgcag                                                   20


<210>  12895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12895
uccaaguucu cuucacaacg                                                   20


<210>  12896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12896
gcuccuccaa guucucuuca                                                   20


<210>  12897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12897
gugccacuuc ccucuucuag                                                   20


<210>  12898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12898
ucuagucuga gagggaagag                                                   20


<210>  12899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12899
gacuagaaga gggaaguggc                                                   20


<210>  12900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12900
cagacuagaa gagggaagug                                                   20


<210>  12901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12901
ucccucucag acuagaagag                                                   20


<210>  12902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12902
aagugucccg cgcccccagc                                                   20


<210>  12903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12903
cgaagugucc cgcgccccca                                                   20


<210>  12904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12904
ucucgaagug ucccgcgccc                                                   20


<210>  12905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12905
aaaccccgcc uccucucgaa                                                   20


<210>  12906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12906
agcuccaaac cccgccuccu                                                   20


<210>  12907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12907
ccagcuccaa accccgccuc                                                   20


<210>  12908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12908
gcgggagugg cggggcaggg                                                   20


<210>  12909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12909
cgccgaggcg uccuaaaagc                                                   20


<210>  12910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12910
ccgccccccc ccugccccgc                                                   20


<210>  12911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12911
cuccccgccc ccccccugcc                                                   20


<210>  12912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12912
cauuggacgc gcccucacuc                                                   20


<210>  12913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12913
ggcuguuuua agugccacua                                                   20


<210>  12914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12914
aaucucaggc uguuuuaagu                                                   20


<210>  12915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12915
uccuacauug ucaggacauu                                                   20


<210>  12916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12916
uagguggugc uuaaaaucgu                                                   20


<210>  12917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12917
ucuaagccua aguuggucug                                                   20


<210>  12918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12918
uucaaacgcc ugcagaccaa                                                   20


<210>  12919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12919
uccuaauauu uaagauaauu                                                   20


<210>  12920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12920
ccaucagcaa cguguugguu                                                   20


<210>  12921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12921
gcaauuaacc uccccaucag                                                   20


<210>  12922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12922
uucaucccuc ggcaauuaac                                                   20


<210>  12923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12923
gugggcaucu cagaugugcc                                                   20


<210>  12924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12924
gaugugccag ugaaaggguu                                                   20


<210>  12925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12925
ccaagaacaa gcaacagaaa                                                   20


<210>  12926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12926
uuuccuguuu caaaaauucu                                                   20


<210>  12927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12927
cuuuuccugu uucaaaaauu                                                   20


<210>  12928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12928
acacacagac uuccagggaa                                                   20


<210>  12929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12929
uacuguacac ucgacacaca                                                   20


<210>  12930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12930
ggugcaguuc aggccuuucu                                                   20


<210>  12931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12931
uaccucucag uauucuauuu                                                   20


<210>  12932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12932
caguauucua uuuccgaucu                                                   20


<210>  12933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12933
guauucuauu uccgaucugg                                                   20


<210>  12934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12934
guuaagacug auuaauuuuu                                                   20


<210>  12935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12935
ucuucaaagu uuaauuagaa                                                   20


<210>  12936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12936
gaaucauuuu cuaauuaaac                                                   20


<210>  12937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12937
ccgaaucauu uucuaauuaa                                                   20


<210>  12938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12938
aaauauccaa aaaguuuuuc                                                   20


<210>  12939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12939
ucaguaagua auuucucauc                                                   20


<210>  12940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12940
uccagaaauu uacuguagug                                                   20


<210>  12941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12941
uagaaaagca cuacaguaaa                                                   20


<210>  12942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12942
ugaugggaag gaagaccuuu                                                   20


<210>  12943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12943
uucuuaugcu gauuugacag                                                   20


<210>  12944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12944
uuugucaagg cagcaaagga                                                   20


<210>  12945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12945
gauuaaaggu guaagccacc                                                   20


<210>  12946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12946
caaagugcuc ggauuaaagg                                                   20


<210>  12947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12947
ggugauucgu ccaccuaggc                                                   20


<210>  12948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12948
ugaccucagg ugauucgucc                                                   20


<210>  12949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12949
aacuccugac cucaggugau                                                   20


<210>  12950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12950
acuaaaaaua caaaaauuag                                                   20


<210>  12951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12951
cagguagcuu ggauuacagg                                                   20


<210>  12952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12952
gccucccagg uagcuuggau                                                   20


<210>  12953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12953
cggguucaag cgauuuuccu                                                   20


<210>  12954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12954
gccucccggg uucaagcgau                                                   20


<210>  12955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12955
cugcagacuc ugccucccgg                                                   20


<210>  12956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12956
acucacugca gacucugccu                                                   20


<210>  12957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12957
agccugggug acagagcgag                                                   20


<210>  12958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12958
gucacccagg cuggagugca                                                   20


<210>  12959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12959
cucugucacc caggcuggag                                                   20


<210>  12960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12960
aucucaaaaa aaauuuuuuu                                                   20


<210>  12961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12961
aaaaaaauuu uuuuuaaugu                                                   20


<210>  12962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12962
gaguaccuaa cuuugucccc                                                   20


<210>  12963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12963
gaggaaaggg guggaaggaa                                                   20


<210>  12964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12964
uguauccugc cagauauaac                                                   20


<210>  12965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12965
aaaaacaaaa guaguuuaga                                                   20


<210>  12966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12966
aaaaauauau agauauauau                                                   20


<210>  12967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12967
cauugucacc caggcuggag                                                   20


<210>  12968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12968
agccugggug acaaugugag                                                   20


<210>  12969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12969
gcucacugca gucucugccu                                                   20


<210>  12970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12970
cugcagucuc ugccucccag                                                   20


<210>  12971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12971
gccucccagg uucaaaugcu                                                   20


<210>  12972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12972
cagguucaaa ugcuucuccu                                                   20


<210>  12973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12973
ugccucagcc uucugaguag                                                   20


<210>  12974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12974
gccuucugag uagcugggau                                                   20


<210>  12975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12975
gaaggcugag gcaggagaag                                                   20


<210>  12976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12976
acuaaaaaua caaaaauuag                                                   20


<210>  12977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12977
ugaccuugug aucuguccac                                                   20


<210>  12978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12978
gccucccaaa gugcugggau                                                   20


<210>  12979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12979
caaagugcug ggauuacagg                                                   20


<210>  12980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12980
caccuguaau cccagcacuu                                                   20


<210>  12981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12981
gaaaucaacu gcauuagguu                                                   20


<210>  12982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12982
guauuuugcu guugagaaag                                                   20


<210>  12983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12983
acagcaaaau acagagaaau                                                   20


<210>  12984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12984
uuucucaaca gcaaaauaca                                                   20


<210>  12985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12985
aaauuaguga auaccuccuu                                                   20


<210>  12986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12986
caaaguuugg auuuuggcag                                                   20


<210>  12987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12987
ucucaaagua agauugauga                                                   20


<210>  12988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12988
aaguaagauu gaugaaagca                                                   20


<210>  12989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12989
ugcucuuugg uguggaacug                                                   20


<210>  12990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12990
uuggugugga acuguggugu                                                   20


<210>  12991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12991
guuuaugagu guuugugcuc                                                   20


<210>  12992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12992
uaaacugagg cccaugcaug                                                   20


<210>  12993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12993
gcucagcaua caggaugcag                                                   20


<210>  12994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12994
gcauacagga ugcaggaguu                                                   20


<210>  12995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12995
ugcauccugu augcugagca                                                   20


<210>  12996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12996
gcaaaucuag caugcuuggg                                                   20


<210>  12997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12997
caagcaugcu agauuugcug                                                   20


<210>  12998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12998
caguaauuag gaggcaauua                                                   20


<210>  12999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  12999
uaauuacugu gaggacccuc                                                   20


<210>  13000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13000
uucagauucc uaucuggugu                                                   20


<210>  13001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13001
gcagugagca gacaaagcuc                                                   20


<210>  13002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13002
cugcugagcc cugcaccuau                                                   20


<210>  13003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13003
gcccucguga agcuuucauu                                                   20


<210>  13004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13004
ugaagcuuuc auucuaauga                                                   20


<210>  13005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13005
acguauuaac guacuguaua                                                   20


<210>  13006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13006
auuaacccug acauuucccu                                                   20


<210>  13007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13007
uuuggaauuu gucuagcagg                                                   20


<210>  13008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13008
aaaaaaacaa aacaaaacaa                                                   20


<210>  13009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13009
aucagccagg cuggagugca                                                   20


<210>  13010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13010
agccuggcug auagagcaag                                                   20


<210>  13011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13011
cugcaaccuc ugccucuugg                                                   20


<210>  13012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13012
gccucuuggg uucaagugau                                                   20


<210>  13013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13013
uggguucaag ugauucucau                                                   20


<210>  13014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13014
ugccucagcc uccuguuuag                                                   20


<210>  13015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13015
gccuccuguu uagcugggau                                                   20


<210>  13016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13016
uguuuagcug ggauuauaga                                                   20


<210>  13017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13017
ggggaaaaaa aaaaaauuac                                                   20


<210>  13018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13018
gucucggggg aaaaaaaaaa                                                   20


<210>  13019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13019
gucgcccagg cuggagugca                                                   20


<210>  13020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13020
agccugggcg acagagcaag                                                   20


<210>  13021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13021
gcucacugca agcuccgcuu                                                   20


<210>  13022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13022
cugcaagcuc cgcuucccga                                                   20


<210>  13023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13023
gcuucccgag uucacgccau                                                   20


<210>  13024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13024
ggaagcggag cuugcaguga                                                   20


<210>  13025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13025
ugccucaguc ucccaaguag                                                   20


<210>  13026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13026
gucucccaag uagcugggac                                                   20


<210>  13027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13027
caaguagcug ggacuacagg                                                   20


<210>  13028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13028
auuaaaaaua caaaaaaauu                                                   20


<210>  13029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13029
ugaccucguc auccgccgac                                                   20


<210>  13030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13030
ucauccgccg accuugugau                                                   20


<210>  13031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13031
gccucccaaa gugcugggau                                                   20


<210>  13032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13032
caaagugcug ggauuacagg                                                   20


<210>  13033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13033
ugccuguaau cccagcacuu                                                   20


<210>  13034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13034
acuaaaaaua caaaaauuac                                                   20


<210>  13035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13035
ucauggcaaa accccaucuc                                                   20


<210>  13036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13036
aacucccggc cucaugugau                                                   20


<210>  13037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13037
cggccucaug ugaucugccu                                                   20


<210>  13038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13038
ugugaucugc cugccuuggc                                                   20


<210>  13039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13039
caaagugcua ggauuacagg                                                   20


<210>  13040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13040
ugccuguaau ccuagcacuu                                                   20


<210>  13041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13041
guggaccuuc ccugaacacc                                                   20


<210>  13042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13042
uuaacccagg cuggaaugca                                                   20


<210>  13043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13043
cuucagccuu gaacuccugg                                                   20


<210>  13044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13044
ugggcucaag ugauccuccc                                                   20


<210>  13045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13045
agugauccuc ccaccucaac                                                   20


<210>  13046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13046
caccucaacc ucacaaugug                                                   20


<210>  13047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13047
accucacaau guguugggac                                                   20


<210>  13048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13048
caauguguug ggacuauagg                                                   20


<210>  13049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13049
caccuauagu cccaacacau                                                   20


<210>  13050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13050
aaagccauca ucuggccagg                                                   20


<210>  13051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13051
agcgaguuaa gagucuagug                                                   20


<210>  13052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13052
cuugaggucu uuacucaaaa                                                   20


<210>  13053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13053
uaacucgcuu gaggucuuua                                                   20


<210>  13054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13054
auucacccaa cuaaaaugac                                                   20


<210>  13055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13055
cucaauucac ccaacuaaaa                                                   20


<210>  13056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13056
uggaccuuac uucuuacuac                                                   20


<210>  13057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13057
cuugaccucu uggaccuuac                                                   20


<210>  13058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13058
cauaaaugcc aauaucuuua                                                   20


<210>  13059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13059
cucacauaaa ugccaauauc                                                   20


<210>  13060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13060
agugacaucc caucucacuc                                                   20


<210>  13061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13061
aauccuccag ugacauccca                                                   20


<210>  13062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13062
gcucuaaucc uccagugaca                                                   20


<210>  13063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13063
ucugcucuaa uccuccagug                                                   20


<210>  13064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13064
ggcugacaac agagugaagg                                                   20


<210>  13065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13065
guugucagcc agaguucacu                                                   20


<210>  13066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13066
gauaagcaug guggguucug                                                   20


<210>  13067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13067
cacugcccac agccgacagc                                                   20


<210>  13068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13068
gcuaaguaua acaauuuagc                                                   20


<210>  13069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13069
ugcuuguuac caguuuaagc                                                   20


<210>  13070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13070
uucuuuuuuu uuuuuuugaa                                                   20


<210>  13071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13071
guuucaaaaa aaaaaaaaag                                                   20


<210>  13072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13072
ugucacccgg gcuggagugc                                                   20


<210>  13073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13073
agcccgggug acaagagcga                                                   20


<210>  13074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13074
gcucacuaaa accucuaccu                                                   20


<210>  13075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13075
cuaaaaccuc uaccuccugg                                                   20


<210>  13076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13076
accuccuggg uucaagugau                                                   20


<210>  13077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13077
uggguucaag ugauucuucu                                                   20


<210>  13078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13078
gccucccaag uaacugggau                                                   20


<210>  13079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13079
caaguaacug ggauuacagg                                                   20


<210>  13080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13080
acuaaaaaca caaaaauuag                                                   20


<210>  13081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13081
aacuucugac cucaggugau                                                   20


<210>  13082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13082
ggugauccac ucgccucagc                                                   20


<210>  13083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13083
ccucagccug ccaaagugcu                                                   20


<210>  13084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13084
gccugccaaa gugcugggau                                                   20


<210>  13085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13085
uucuuauacu uaccuugcaa                                                   20


<210>  13086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13086
uuuuuucccu uuguauuuuu                                                   20


<210>  13087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13087
cccuuccuuu ggauugucuu                                                   20


<210>  13088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13088
cuuccuuugg auugucuuuu                                                   20


<210>  13089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13089
acuucaucaa aauuaaaaac                                                   20


<210>  13090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13090
uauguuuucu ucuaagaauu                                                   20


<210>  13091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13091
aaaauucuua gaagaaaaca                                                   20


<210>  13092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13092
aaauggauca gacuuaaaug                                                   20


<210>  13093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13093
ucaacaaaca gugcugggac                                                   20


<210>  13094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13094
cauuucauga auuuaaacug                                                   20


<210>  13095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13095
aacuuuguuc cuuuucaaga                                                   20


<210>  13096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13096
gaauccuacu uggcuucuuu                                                   20


<210>  13097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13097
cagaauccua cuuggcuucu                                                   20


<210>  13098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13098
ccaaguugau cuacagauuc                                                   20


<210>  13099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13099
gucacagcua cgcggcucug                                                   20


<210>  13100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13100
gccauuguag caugaaagua                                                   20


<210>  13101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13101
uacauauugc uuauggcuac                                                   20


<210>  13102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13102
ugacagguga aaauuauaug                                                   20


<210>  13103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13103
uagguuaaaa uaugauagga                                                   20


<210>  13104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13104
aaaaaaaaaa aaaaaaaaaa                                                   20


<210>  13105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13105
gucucaaaaa aaaaaaaaaa                                                   20


<210>  13106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13106
uguugcccag gcuggagugc                                                   20


<210>  13107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13107
agccugggca acaagaguga                                                   20


<210>  13108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13108
gcucacugca accucugccu                                                   20


<210>  13109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13109
cugcaaccuc ugccucccag                                                   20


<210>  13110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13110
gccucccagg uucaagacau                                                   20


<210>  13111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13111
cagguucaag acauucuccu                                                   20


<210>  13112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13112
ugcacggccu cccuaguagc                                                   20


<210>  13113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13113
cuaguagcug ggauuacagg                                                   20


<210>  13114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13114
acuaaaaaua caaaauuagc                                                   20


<210>  13115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13115
auguugguca ggcuggucuu                                                   20


<210>  13116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13116
ugaccucagg ugauccaccc                                                   20


<210>  13117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13117
ggugauccac ccgccucagc                                                   20


<210>  13118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13118
gccucccaaa gugcugggau                                                   20


<210>  13119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13119
caaagugcug ggauuacagg                                                   20


<210>  13120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13120
cacccuguaa ucccagcacu                                                   20


<210>  13121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13121
gucaagcaaa caaaaaauga                                                   20


<210>  13122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13122
uuuaaaaaga aauucuaaaa                                                   20


<210>  13123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13123
aaaaguccuc uuuuaaaaag                                                   20


<210>  13124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13124
cauuuuugug gcuguagaau                                                   20


<210>  13125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13125
cuaccuugag aaguccccau                                                   20


<210>  13126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13126
accuugagaa guccccaucc                                                   20


<210>  13127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13127
agguagagag aauaugucac                                                   20


<210>  13128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13128
auuuccugua aauaagucaa                                                   20


<210>  13129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13129
aaacauuuag ucuuauucag                                                   20


<210>  13130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13130
uuguugucug aauaagacua                                                   20


<210>  13131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13131
aacauacauu cuagccccca                                                   20


<210>  13132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13132
cugugauagc aaggaccuau                                                   20


<210>  13133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13133
gggacagucg uuugguauca                                                   20


<210>  13134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13134
uaagcagacu cucucugcuu                                                   20


<210>  13135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13135
cucugcuuga ccugacaaau                                                   20


<210>  13136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13136
cugcuugacc ugacaaauca                                                   20


<210>  13137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13137
gcuugaccug acaaaucaga                                                   20


<210>  13138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13138
gauuugucag gucaagcaga                                                   20


<210>  13139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13139
cugaaccugu uaaaacacag                                                   20


<210>  13140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13140
aaugugcaug uaagucacuc                                                   20


<210>  13141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13141
acuguaggug cuuagaccuu                                                   20


<210>  13142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13142
caaaugcuug cauuguuauu                                                   20


<210>  13143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13143
uaugugucca gguguagcug                                                   20


<210>  13144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13144
gcuacaccug gacacauaug                                                   20


<210>  13145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13145
acggcccuac agcagauaag                                                   20


<210>  13146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13146
ucacagcuac agaaaugcuc                                                   20


<210>  13147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13147
cucaucacag cuacagaaau                                                   20


<210>  13148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13148
gcucacucau cacagcuaca                                                   20


<210>  13149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13149
ccucagcuca cucaucacag                                                   20


<210>  13150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13150
gcaggcucac cucagcucac                                                   20


<210>  13151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13151
ccgcaggcuc accucagcuc                                                   20


<210>  13152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13152
cagccauugg uagugggacu                                                   20


<210>  13153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13153
cuuagaugaa cuggaaggac                                                   20


<210>  13154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13154
gaugaaaggg uccuuccagu                                                   20


<210>  13155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13155
auaguggcug cucagaugaa                                                   20


<210>  13156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13156
uucgguuguu uuucuccaua                                                   20


<210>  13157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13157
ccucauucgg uuguuuuucu                                                   20


<210>  13158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13158
ccccucauuc gguuguuuuu                                                   20


<210>  13159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13159
uuugugcccu aaauaaaauu                                                   20


<210>  13160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13160
ccuuugugcc cuaaauaaaa                                                   20


<210>  13161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13161
aaugucaccu ucuaaccaca                                                   20


<210>  13162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13162
cgcuauacac auggcuugcc                                                   20


<210>  13163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13163
ucucccgcua uacacauggc                                                   20


<210>  13164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13164
cuucucccgc uauacacaug                                                   20


<210>  13165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13165
gccuggaccu cucuucuccc                                                   20


<210>  13166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13166
aacauggaaa gcauuucugc                                                   20


<210>  13167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13167
uuacugguuc ucaaacaugg                                                   20


<210>  13168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13168
uccuuauuuc ugcccuucac                                                   20


<210>  13169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13169
cagccucauc cuuauuucug                                                   20


<210>  13170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13170
cgcagccuca uccuuauuuc                                                   20


<210>  13171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13171
ucucucgcag ccucauccuu                                                   20


<210>  13172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13172
caucucucgc agccucaucc                                                   20


<210>  13173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13173
aaccucucau cucucgcagc                                                   20


<210>  13174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13174
ucucuaaccu cucaucucuc                                                   20


<210>  13175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13175
aacuacuggu auuacaggca                                                   20


<210>  13176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13176
caccacaccg ucucaaacua                                                   20


<210>  13177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13177
ggcaauccuc ccaccacacc                                                   20


<210>  13178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13178
acaaaaaacu uuaaaaaauu                                                   20


<210>  13179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13179
ggaggcugag gaggcuggag                                                   20


<210>  13180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13180
ugaguagcug ggacuacagg                                                   20


<210>  13181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13181
gccuccugag uagcugggac                                                   20


<210>  13182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13182
ucagccuccu gaguagcugg                                                   20


<210>  13183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13183
agccuccuca gccuccugag                                                   20


<210>  13184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13184
agcaauccuc cagccuccuc                                                   20


<210>  13185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13185
uggacucaag caauccucca                                                   20


<210>  13186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13186
aacuccugga cucaagcaau                                                   20


<210>  13187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13187
cugcagccuc aaacuccugg                                                   20


<210>  13188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13188
ugcccagguu guaguguagu                                                   20


<210>  13189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13189
cuugcccagg uuguagugua                                                   20


<210>  13190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13190
cucucuugcc cagguuguag                                                   20


<210>  13191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13191
aaauauacac acacacacac                                                   20


<210>  13192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13192
ccagcaugug guauugucaa                                                   20


<210>  13193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13193
ggaaaacagu uuggcaguuu                                                   20


<210>  13194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13194
aggauuaaug cccaggauug                                                   20


<210>  13195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13195
aguaugcaua gcagcuuuac                                                   20


<210>  13196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13196
gauguccuuc aacaggugaa                                                   20


<210>  13197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13197
guaauaaaaa ggaaugagcu                                                   20


<210>  13198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13198
uuccuuuuua uuacugagua                                                   20


<210>  13199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13199
aucccuaaaa cugugccauu                                                   20


<210>  13200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13200
aaccccaggc aaccacuaau                                                   20


<210>  13201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13201
acuaccccau cucuaacccc                                                   20


<210>  13202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13202
gccaccacua accuacucua                                                   20


<210>  13203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13203
ucugccacca cuaaccuacu                                                   20


<210>  13204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13204
ccucugccac cacuaaccua                                                   20


<210>  13205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13205
uuucucuccu cugccaccac                                                   20


<210>  13206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13206
cuuuucucuc cucugccacc                                                   20


<210>  13207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13207
cucucuuuuc ucuccucugc                                                   20


<210>  13208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13208
gucgccaaaa aaaaaaaaaa                                                   20


<210>  13209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13209
guugcccagg cuggagugca                                                   20


<210>  13210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13210
agccugggca acagagcaag                                                   20


<210>  13211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13211
cugcaaccuc ugccuccugg                                                   20


<210>  13212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13212
gccuccuggg uucaagugau                                                   20


<210>  13213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13213
uggguucaag ugauacuugu                                                   20


<210>  13214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13214
gucucccaug uucagaguga                                                   20


<210>  13215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13215
cauguucaga gugaaacaaa                                                   20


<210>  13216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13216
gaacauggga gacugagaca                                                   20


<210>  13217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13217
gguuuguuuc acucugaaca                                                   20


<210>  13218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13218
ugccuguaau cccagcacuu                                                   20


<210>  13219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13219
caaaagugcu gggauuacag                                                   20


<210>  13220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13220
agugaucugc ccaccuuggc                                                   20


<210>  13221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13221
ugaccucaag ugaucugccc                                                   20


<210>  13222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13222
aacuccugac cucaagugau                                                   20


<210>  13223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13223
caaguagcug ggacuacagg                                                   20


<210>  13224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13224
gccucccaag uagcugggac                                                   20


<210>  13225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13225
ugccucagcc ucccaaguag                                                   20


<210>  13226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13226
gguucaagca guucucuugc                                                   20


<210>  13227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13227
gccccucggg uucaagcagu                                                   20


<210>  13228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13228
cugcaaccuc ugccccucgg                                                   20


<210>  13229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13229
gcucacugca accucugccc                                                   20


<210>  13230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13230
cagcucacug caaccucugc                                                   20


<210>  13231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13231
gucacacagg cugaagugca                                                   20


<210>  13232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13232
aucuccaaaa aaaaaaaacc                                                   20


<210>  13233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13233
aaaaaaaaaa aaccaagauc                                                   20


<210>  13234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13234
caccuguaau cccagcacuu                                                   20


<210>  13235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13235
caaagugcug ggauuacagg                                                   20


<210>  13236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13236
gccucccaaa gugcugggau                                                   20


<210>  13237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13237
ugaucugccc aucucggccu                                                   20


<210>  13238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13238
ugaccucgug aucugcccau                                                   20


<210>  13239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13239
acuaaaaaau acaaaaaauu                                                   20


<210>  13240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13240
caaguagcug ggacuacagg                                                   20


<210>  13241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13241
ugcuucagcc ucccaaguag                                                   20


<210>  13242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13242
cggguucaca ccauucuccu                                                   20


<210>  13243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13243
gccucccggg uucacaccau                                                   20


<210>  13244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13244
cugccagcuc ugccucccgg                                                   20


<210>  13245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13245
gcucacugcc agcucugccu                                                   20


<210>  13246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13246
agccugggcg acagagcaag                                                   20


<210>  13247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13247
gucgcccagg cuggagugca                                                   20


<210>  13248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13248
gucucggggg aaaaaaaaaa                                                   20


<210>  13249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13249
ggggaaaaaa aaaaauaaau                                                   20


<210>  13250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13250
aggacacuac agcauucuau                                                   20


<210>  13251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13251
uuacgcuugu gugcccgugc                                                   20


<210>  13252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13252
aauuguguaa ucaagcaauc                                                   20


<210>  13253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13253
ucuaauugug uaaucaagca                                                   20


<210>  13254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13254
gccagccucc ucuaauugug                                                   20


<210>  13255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13255
aaaaaaaaaa aauuaaaaca                                                   20


<210>  13256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13256
guuccccagg cuagagugca                                                   20


<210>  13257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13257
agccugggga acagagccag                                                   20


<210>  13258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13258
gccuccuggg uucaagcagu                                                   20


<210>  13259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13259
uggguucaag caguucuucu                                                   20


<210>  13260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13260
cgaguagcug ggauuauagg                                                   20


<210>  13261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13261
ggaggcugcg gcagaagaac                                                   20


<210>  13262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13262
acuaaaaaua caaaaaauag                                                   20


<210>  13263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13263
aacuccugac cucagaugau                                                   20


<210>  13264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13264
ugaccucaga ugaucugcug                                                   20


<210>  13265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13265
gaugaucugc ugccccagcc                                                   20


<210>  13266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13266
caaagugcug ggauuacagg                                                   20


<210>  13267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13267
cgccuguaau cccagcacuu                                                   20


<210>  13268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13268
gagcaaggug guuucuuuuu                                                   20


<210>  13269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13269
gagcaagaac uggaaaaaca                                                   20


<210>  13270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13270
aacugacuug uucuacauga                                                   20


<210>  13271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13271
uuuuguccaa uaagcaaacc                                                   20


<210>  13272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13272
gaaacuuagu agucuuuuag                                                   20


<210>  13273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13273
cuacuuuauu uugauagugc                                                   20


<210>  13274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13274
acuuuauuuu gauagugcca                                                   20


<210>  13275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13275
uucccaucca aaccuauggc                                                   20


<210>  13276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13276
uuuugcuugg cugagaaguc                                                   20


<210>  13277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13277
gccaagcaaa aggagauaaa                                                   20


<210>  13278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13278
uauuaagacu ucucagccaa                                                   20


<210>  13279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13279
guaaaauaua agcaauggcu                                                   20


<210>  13280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13280
aaaucguuaa cugacuacaa                                                   20


<210>  13281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13281
auauauacca ggcugccuuc                                                   20


<210>  13282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13282
uguaaucuau gccaucaucu                                                   20


<210>  13283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13283
gcaguacaga agaugauggc                                                   20


<210>  13284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13284
aucaauuuca cguuugaauc                                                   20


<210>  13285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13285
guauuucacc aauacucaau                                                   20


<210>  13286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13286
ucuguauuuc accaauacuc                                                   20


<210>  13287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13287
cuauaauggg ggaagugagg                                                   20


<210>  13288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13288
auaauggggg aagugaggcc                                                   20


<210>  13289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13289
cuucccccau uauagagaga                                                   20


<210>  13290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13290
uaccuauaau cccagugcuu                                                   20


<210>  13291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13291
caaagcacug ggauuauagg                                                   20


<210>  13292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13292
agcgaucuuc ccaucuuggc                                                   20


<210>  13293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13293
uggccucaag cgaucuuccc                                                   20


<210>  13294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13294
aacuccuggc cucaagcgau                                                   20


<210>  13295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13295
cgauguugcc caauugcuca                                                   20


<210>  13296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13296
acaaaauauu uugaaaaaau                                                   20


<210>  13297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13297
ggaggcugag acgggaggau                                                   20


<210>  13298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13298
ugaguggcgc ggaccacagg                                                   20


<210>  13299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13299
gccuccugag uggcgcggac                                                   20


<210>  13300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13300
cgucucagcc uccugagugg                                                   20


<210>  13301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13301
uaggcugaaa ggauccuccc                                                   20


<210>  13302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13302
cuuuagccuu aaacuccuag                                                   20


<210>  13303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13303
agccugggca gcagagcaag                                                   20


<210>  13304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13304
gcugcccagg cuggaguacg                                                   20


<210>  13305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13305
aaaaaaaagu aaaauaaagu                                                   20


<210>  13306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13306
cagaaaaaac agaugauguu                                                   20


<210>  13307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13307
ugcccugugc uucccugucc                                                   20


<210>  13308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13308
auguugcggg cagaaugggg                                                   20


<210>  13309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13309
acuacuauga auaaaccguu                                                   20


<210>  13310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13310
cugaaugaau gaaugaggug                                                   20


<210>  13311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13311
uucauucauu cagugagugu                                                   20


<210>  13312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13312
acuuaguucu acaccucauu                                                   20


<210>  13313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13313
agacaguuca aagugcaauu                                                   20


<210>  13314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13314
cuuauuugcu uuuucuuggc                                                   20


<210>  13315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13315
uauuugcuuu uucuuggcag                                                   20


<210>  13316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13316
gcuccuagca guggcuggag                                                   20


<210>  13317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13317
uagcaguggc uggagcccac                                                   20


<210>  13318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13318
agccacugcu aggagcagag                                                   20


<210>  13319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13319
ucugugcuuc gggauuagug                                                   20


<210>  13320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13320
gugcuucggg auuagugggg                                                   20


<210>  13321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13321
cugggaugaa cuagcagcac                                                   20


<210>  13322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13322
guaggagaca uauucaccua                                                   20


<210>  13323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13323
uacugagcca uuggaaacag                                                   20


<210>  13324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13324
ugguagaagc uagaaaaagc                                                   20


<210>  13325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13325
aaaaaaaauu aaaaaaagaa                                                   20


<210>  13326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13326
gucucaaaaa aaaauuaaaa                                                   20


<210>  13327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13327
uguugcccag gcuggagugc                                                   20


<210>  13328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13328
agccugggca acaagaguga                                                   20


<210>  13329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13329
gcucacugca accucugccu                                                   20


<210>  13330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13330
cugcaaccuc ugccuccugg                                                   20


<210>  13331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13331
gccuccuggg uucaagugau                                                   20


<210>  13332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13332
uggguucaag ugauucuccu                                                   20


<210>  13333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13333
ugccucagcc ucccaaguag                                                   20


<210>  13334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13334
gccucccaag uagcuggagu                                                   20


<210>  13335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13335
caaguagcug gaguuacagg                                                   20


<210>  13336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13336
agcuacuugg gaggcugagg                                                   20


<210>  13337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13337
acuaaaaaua caaaauuagc                                                   20


<210>  13338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13338
aacucccaac cuuaggugau                                                   20


<210>  13339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13339
caaccuuagg ugaucugccc                                                   20


<210>  13340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13340
gccucccaaa gugcugggau                                                   20


<210>  13341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13341
caaagugcug ggauuacagg                                                   20


<210>  13342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13342
cgccuguaau cccagcacuu                                                   20


<210>  13343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13343
uggccauugc uuuucacuuu                                                   20


<210>  13344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13344
aaaaaaaaaa aaaaacaaaa                                                   20


<210>  13345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13345
gucucaaaaa aaaaaaaaaa                                                   20


<210>  13346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13346
agccugggug acagaucgug                                                   20


<210>  13347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13347
gccucccagg uucacgccau                                                   20


<210>  13348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13348
cagguucacg ccauucuccu                                                   20


<210>  13349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13349
ugcuucagcc uggcgaguag                                                   20


<210>  13350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13350
ccaggcugaa gcaggagaau                                                   20


<210>  13351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13351
ccaccacacc cggcuaauuu                                                   20


<210>  13352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13352
acuaaaaaua caaaaaauua                                                   20


<210>  13353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13353
ugaccucaug acccgcucaa                                                   20


<210>  13354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13354
ugacccgcuc aacucagccu                                                   20


<210>  13355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13355
acucagccuc ccaaagugcu                                                   20


<210>  13356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13356
gccucccaaa gugcugggau                                                   20


<210>  13357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13357
caaagugcug ggauuacagg                                                   20


<210>  13358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13358
cgccuguaau cccagcacuu                                                   20


<210>  13359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13359
cuugucuuuu uauuguggua                                                   20


<210>  13360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13360
ugucuuuuua uugugguaaa                                                   20


<210>  13361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13361
cuaucaucca uucuuuccug                                                   20


<210>  13362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13362
uacagacaga aaguagaaag                                                   20


<210>  13363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13363
ggagaccuca uguaagugga                                                   20


<210>  13364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13364
agagcaguua cacucauaca                                                   20


<210>  13365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13365
uguaagugga uuccuacagg                                                   20


<210>  13366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13366
gugcauuugu auuauauacu                                                   20


<210>  13367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13367
uuucuguugu uugugaaaua                                                   20


<210>  13368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13368
uuuguuauuu cauuuucuuc                                                   20


<210>  13369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13369
gcuaccugug uaagcugggu                                                   20


<210>  13370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13370
aacacguuac agcuuaucua                                                   20


<210>  13371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13371
uuuuugaaau guaaucccua                                                   20


<210>  13372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13372
gguggcuaau gaacauaucu                                                   20


<210>  13373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13373
aaaaaaaaaa aguaaagaua                                                   20


<210>  13374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13374
gucucaaaaa aaaaaaagua                                                   20


<210>  13375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13375
guugcccagg cuagagugca                                                   20


<210>  13376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13376
agccugggca acagagcaag                                                   20


<210>  13377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13377
gcucacugca agcuccaccu                                                   20


<210>  13378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13378
cugcaagcuc caccucccgg                                                   20


<210>  13379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13379
accucccggg uucacgcuau                                                   20


<210>  13380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13380
cggguucacg cuauucuccu                                                   20


<210>  13381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13381
ugccccagcc ucccaaguag                                                   20


<210>  13382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13382
caaguagcug ggacuacagg                                                   20


<210>  13383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13383
acuaaaaaua caaaaauuua                                                   20


<210>  13384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13384
ugaccucgug auccgcccgc                                                   20


<210>  13385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13385
ugauccgccc gccucggccu                                                   20


<210>  13386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13386
gccucccaaa gugcugggau                                                   20


<210>  13387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13387
caaagugcug ggauuacagg                                                   20


<210>  13388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13388
cgccuguaau cccagcacuu                                                   20


<210>  13389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13389
accauccagg ucucagagaa                                                   20


<210>  13390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13390
gagaacauaa uuucucucug                                                   20


<210>  13391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13391
gagaccugga ugguggagau                                                   20


<210>  13392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13392
cugaaagcuu auugacccag                                                   20


<210>  13393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13393
gaaagcuuau ugacccagga                                                   20


<210>  13394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13394
uucaaucuga gugcgucagg                                                   20


<210>  13395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13395
gauugaaaga gaucuuauuu                                                   20


<210>  13396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13396
acauacuuua cuaauauaug                                                   20


<210>  13397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13397
uguuuuuaug gaguaaugcu                                                   20


<210>  13398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13398
auaaaaacaa gagacagacu                                                   20


<210>  13399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13399
gcauuacucc auaaaaacaa                                                   20


<210>  13400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13400
cagcauuacu ccauaaaaac                                                   20


<210>  13401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13401
ucuguagaac aagcauaaug                                                   20


<210>  13402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13402
uuuuaacaug cucuucugua                                                   20


<210>  13403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13403
aaaaacuccu uuuaacaugc                                                   20


<210>  13404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13404
gacuccaaaa acuccuuuua                                                   20


<210>  13405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13405
cugacuccaa aaacuccuuu                                                   20


<210>  13406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13406
auacuuuuua gggauuucag                                                   20


<210>  13407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13407
gaaaucccua aaaaguauag                                                   20


<210>  13408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13408
ucgcuguuuc cuguuaacuc                                                   20


<210>  13409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13409
ccuaaaauau aauuaaacuu                                                   20


<210>  13410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13410
uaaaauauaa uuaaacuuuu                                                   20


<210>  13411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13411
aaugagguua uauaaauggc                                                   20


<210>  13412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13412
uuagagacaa aaauuagucu                                                   20


<210>  13413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13413
cuaaaguggu cuaaguuacu                                                   20


<210>  13414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13414
aaaguggucu aaguuacugg                                                   20


<210>  13415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13415
uccauacuua ggaaccagua                                                   20


<210>  13416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13416
cuguccuuuu ucccaaacau                                                   20


<210>  13417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13417
aacagaaugc agaaguaugu                                                   20


<210>  13418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13418
ugggaauacc caggaaugcu                                                   20


<210>  13419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13419
aguaagcauu ccuggguauu                                                   20


<210>  13420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13420
uacuaauaug uaccuugaua                                                   20


<210>  13421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13421
cauauauuag cauaaaucag                                                   20


<210>  13422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13422
aaggaaucga uaaauaugca                                                   20


<210>  13423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13423
aaauuaacac agaaauuuaa                                                   20


<210>  13424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13424
acuagaauuu ugaucaagau                                                   20


<210>  13425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13425
aaaucaucac caggccuggu                                                   20


<210>  13426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13426
caaagugcug ggauuacagg                                                   20


<210>  13427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13427
gccucccaaa gugcugggau                                                   20


<210>  13428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13428
ggugaucugc cugccucagc                                                   20


<210>  13429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13429
ugaccucagg ugaucugccu                                                   20


<210>  13430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13430
aacucuugac cucaggugau                                                   20


<210>  13431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13431
acuaaaaaua caaaaauuag                                                   20


<210>  13432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13432
caaguagcug ggacuacagg                                                   20


<210>  13433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13433
gccucccaag uagcugggac                                                   20


<210>  13434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13434
ugccucagcc ucccaaguag                                                   20


<210>  13435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13435
uggguucaag caauucuccu                                                   20


<210>  13436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13436
ccgcaaccug uaccuccugg                                                   20


<210>  13437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13437
ugucgcccag gcuggaaugc                                                   20


<210>  13438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13438
agaaaaaaga gaaaaaagaa                                                   20


<210>  13439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13439
uuuuucuuga gacagaauuu                                                   20


<210>  13440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13440
ccauauuagu guugauuucu                                                   20


<210>  13441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13441
ucuuucuguu cuauaccugu                                                   20


<210>  13442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13442
uuucccuaau acauauaugu                                                   20


<210>  13443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13443
gacuuuggga gaacauuaua                                                   20


<210>  13444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13444
caaagucaga gaaauguauc                                                   20


<210>  13445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13445
accucauauu gcaaacaaac                                                   20


<210>  13446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13446
uauugcaaac aaacauaaag                                                   20


<210>  13447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13447
aacuaagauu acauuuuuua                                                   20


<210>  13448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13448
aaacaguuuu uuccuuuaua                                                   20


<210>  13449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13449
uuacacaggc uaguaaccuu                                                   20


<210>  13450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13450
gacucccagc cuccagaacu                                                   20


<210>  13451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13451
cagccuccag aacugugacg                                                   20


<210>  13452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13452
agaacuguga cgaguaagug                                                   20


<210>  13453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13453
ucacaguucu ggaggcuggg                                                   20


<210>  13454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13454
agcugauuag gacacuagua                                                   20


<210>  13455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13455
gacaaaaauc ugaauauucu                                                   20


<210>  13456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13456
agggugcuua ccccuaggaa                                                   20


<210>  13457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13457
auaaacacau aaauaaauau                                                   20


<210>  13458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13458
aucucaauaa acacauaaau                                                   20


<210>  13459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13459
ggcccaggcg gacagugcaa                                                   20


<210>  13460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13460
gcucacugca accucugcuu                                                   20


<210>  13461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13461
cugcaaccuc ugcuucccgg                                                   20


<210>  13462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13462
gcuucccggg uucaugugau                                                   20


<210>  13463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13463
ugccucagcc uccugaguag                                                   20


<210>  13464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13464
gccuccugag uagcugggau                                                   20


<210>  13465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13465
ugaguagcug ggauuacagg                                                   20


<210>  13466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13466
ggaggcugag gcaggagaau                                                   20


<210>  13467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13467
caccaccgca cccggcuaau                                                   20


<210>  13468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13468
acuaaaaaua caaaaaauua                                                   20


<210>  13469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13469
aacuccugac cucaugaucc                                                   20


<210>  13470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13470
ugaccucaug auccgcgccc                                                   20


<210>  13471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13471
ugauccgcgc cccucggccu                                                   20


<210>  13472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13472
gccucccagu guugggauua                                                   20


<210>  13473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13473
caguguuggg auuacaggug                                                   20


<210>  13474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13474
caccuguaau cccaacacug                                                   20


<210>  13475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13475
uguauaaaug uaucuggcca                                                   20


<210>  13476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13476
aaaaaaaauu uuuuuaauaa                                                   20


<210>  13477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13477
gucacccagg caggaugcag                                                   20


<210>  13478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13478
ugggcuuaag ugauccuucu                                                   20


<210>  13479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13479
gccuuuugag uaccuggggg                                                   20


<210>  13480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13480
aaaggcugag gcagaaggau                                                   20


<210>  13481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13481
ucuauaaaac auuuaaaaau                                                   20


<210>  13482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13482
caccuuggcc ucccaaagcg                                                   20


<210>  13483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13483
caaagcgcug agauuacagg                                                   20


<210>  13484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13484
gcgcuuuggg aggccaaggu                                                   20


<210>  13485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13485
ugccuguaau cucagcgcuu                                                   20


<210>  13486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13486
acauucauuu uccugggaua                                                   20


<210>  13487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13487
ccacauucau uuuccuggga                                                   20


<210>  13488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13488
ugccaugacc aggcaguaau                                                   20


<210>  13489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13489
guuuuuccuc uugccaugac                                                   20


<210>  13490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13490
caguuuuucc ucuugccaug                                                   20


<210>  13491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13491
ucucaguuuu uccucuugcc                                                   20


<210>  13492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13492
gucuccucuc aguuuuuccu                                                   20


<210>  13493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13493
gccucagucu ccucucaguu                                                   20


<210>  13494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13494
acccagcaaa ccacuggcuc                                                   20


<210>  13495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13495
ucaacccagc aaaccacugg                                                   20


<210>  13496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13496
gccuccucaa cccagcaaac                                                   20


<210>  13497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13497
cagcucugcc uccucaaccc                                                   20


<210>  13498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13498
gcacucccag cucugccucc                                                   20


<210>  13499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13499
ccaccuugca ucucugcacu                                                   20


<210>  13500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13500
caccaccuug caucucugca                                                   20


<210>  13501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13501
ucccugguau ucuuccauau                                                   20


<210>  13502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13502
cuucccuggu auucuuccau                                                   20


<210>  13503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13503
gcagcucucu ucccugguau                                                   20


<210>  13504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13504
cucugcagcu cucuucccug                                                   20


<210>  13505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13505
ggagaccugc acccugcccu                                                   20


<210>  13506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13506
ggagcucccu cugcagcucu                                                   20


<210>  13507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13507
caguacccug ucaugugugu                                                   20


<210>  13508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13508
guacccuguc auguguguag                                                   20


<210>  13509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13509
gcuacacaca ugacagggua                                                   20


<210>  13510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13510
ucaguacuca gcuacacaca                                                   20


<210>  13511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13511
agcccugggu cauuuccgca                                                   20


<210>  13512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13512
accuccagcc cugggucauu                                                   20


<210>  13513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13513
aacuggugug auuagaaauu                                                   20


<210>  13514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13514
gcucucauag agcagguagg                                                   20


<210>  13515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13515
cauagagcag guaggguacu                                                   20


<210>  13516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13516
uagagcaggu aggguacuca                                                   20


<210>  13517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13517
augagagcug agguuuucca                                                   20


<210>  13518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13518
gaaggguuug cccaccuagc                                                   20


<210>  13519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13519
gacccuaccu aauauuaaaa                                                   20


<210>  13520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13520
uuuuaauauu agguaggguc                                                   20


<210>  13521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13521
uccagccuuu augcuauugu                                                   20


<210>  13522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13522
ccucuuuccc caaaagauau                                                   20


<210>  13523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13523
uuccccaaaa gauaucaagu                                                   20


<210>  13524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13524
agggauuagg acuugauauc                                                   20


<210>  13525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13525
agauccugaa uuuaaucaca                                                   20


<210>  13526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13526
ucucaagauc cugaauuuaa                                                   20


<210>  13527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13527
uuuuuauaua uaugugauug                                                   20


<210>  13528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13528
gccuccuuuu uauauauaug                                                   20


<210>  13529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13529
cucugccucc uuuuuauaua                                                   20


<210>  13530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13530
guguguaaaa ucucccucug                                                   20


<210>  13531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13531
cuguguguaa aaucucccuc                                                   20


<210>  13532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13532
aauuuucaag gccagcaccu                                                   20


<210>  13533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13533
uccagcuuug guggcugcug                                                   20


<210>  13534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13534
gugccucuuc cagcuuuggu                                                   20


<210>  13535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13535
uuuagagccu acuccagagg                                                   20


<210>  13536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13536
aaaugagaac ugcuccgugc                                                   20


<210>  13537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13537
agagggaaug uggugcugcc                                                   20


<210>  13538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13538
ggaguaggcu cuaaaugaga                                                   20


<210>  13539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13539
aagaaacacc caagaaugau                                                   20


<210>  13540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13540
ccaagaaaca cccaagaaug                                                   20


<210>  13541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13541
acuauugucc uaugacccug                                                   20


<210>  13542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13542
gguuuuccua ggcagagggc                                                   20


<210>  13543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13543
gccuaggaaa accagagacc                                                   20


<210>  13544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13544
aguacccagg gacacaaaca                                                   20


<210>  13545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13545
cuaaucucaa guacccaggg                                                   20


<210>  13546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13546
uaacgaguau gcugccuuca                                                   20


<210>  13547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13547
uuaagaguca ucaccacucc                                                   20


<210>  13548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13548
gaaacaugug cuguguccac                                                   20


<210>  13549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13549
cugaaacaug ugcugugucc                                                   20


<210>  13550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13550
auuuuguucu guacuaagaa                                                   20


<210>  13551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13551
cuuucuuuuc ccacauuucc                                                   20


<210>  13552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13552
uucuuuuccc acauuuccuc                                                   20


<210>  13553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13553
uuuucuauuc gacaaaacug                                                   20


<210>  13554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13554
augagcuauu ggguacaccu                                                   20


<210>  13555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13555
uugagaacag uccaugauga                                                   20


<210>  13556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13556
cagauggggu ggcggccggg                                                   20


<210>  13557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13557
gcccggccgc caccccaucu                                                   20


<210>  13558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13558
ucacuuccca gauggggcgg                                                   20


<210>  13559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13559
cuucccagau ggggcggccg                                                   20


<210>  13560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13560
gcccggccgc cccaucuggg                                                   20


<210>  13561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13561
cagacggggc ggcggcuggg                                                   20


<210>  13562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13562
cggacggggc ggguggccgg                                                   20


<210>  13563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13563
cggacggggc ggcuggccgg                                                   20


<210>  13564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13564
cggacggggc ggguggccgg                                                   20


<210>  13565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13565
cggacggggc ggcuggccgg                                                   20


<210>  13566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13566
cggacggagc ggcugccggg                                                   20


<210>  13567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13567
guccgggagg uggggggcag                                                   20


<210>  13568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13568
gcccggcagc cgcuccgucc                                                   20


<210>  13569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13569
ucacuucccg gacggggcgg                                                   20


<210>  13570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13570
cuucccggac ggggcggcug                                                   20


<210>  13571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13571
gcccagcagc cgccccgucc                                                   20


<210>  13572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13572
ucacuucuca gacggggcgg                                                   20


<210>  13573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13573
cuucucagac ggggcggcug                                                   20


<210>  13574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13574
gacggggcgg cuggucagag                                                   20


<210>  13575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13575
gaccagccgc cccgucugag                                                   20


<210>  13576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13576
ucaccuccca gacggggugg                                                   20


<210>  13577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13577
ccucccagac gggguggcag                                                   20


<210>  13578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13578
cagacggggu ggcagugggg                                                   20


<210>  13579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13579
gccccacugc caccccgucu                                                   20


<210>  13580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13580
gucugggaac uuaagaaugu                                                   20


<210>  13581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13581
gcccggccgu gacuccgucu                                                   20


<210>  13582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13582
ucacaucuca gacggggcgg                                                   20


<210>  13583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13583
gacggggcgg cggggcagag                                                   20


<210>  13584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13584
gccccgccgc cccgucugag                                                   20


<210>  13585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13585
ccacuuccca gacgaugggc                                                   20


<210>  13586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13586
gcccggccgc ccaucgucug                                                   20


<210>  13587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13587
ucacuuccua gaugggauga                                                   20


<210>  13588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13588
cuuccuagau gggaugacag                                                   20


<210>  13589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13589
ucccggcugu caucccaucu                                                   20


<210>  13590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13590
ucacuuccca gacugggcag                                                   20


<210>  13591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13591
cuucccagac ugggcagcca                                                   20


<210>  13592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13592
gccuggcugc ccagucuggg                                                   20


<210>  13593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13593
ucacauccca gacgaugggc                                                   20


<210>  13594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13594
caucccagac gaugggcggc                                                   20


<210>  13595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13595
ucacuuccua gacggggugg                                                   20


<210>  13596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13596
cuuccuagac gggguggcgg                                                   20


<210>  13597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13597
gcccagccgc caccccgucu                                                   20


<210>  13598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13598
caaagugcca agauugcggc                                                   20


<210>  13599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13599
cagccgccug ccuuggccuc                                                   20


<210>  13600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13600
ggucacuaca accuucaccu                                                   20


<210>  13601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13601
agccugggca acacugagca                                                   20


<210>  13602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13602
guguugccca ggcuggagug                                                   20


<210>  13603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13603
gugcucagug uugcccaggc                                                   20


<210>  13604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13604
cucagugcuc aguguugccc                                                   20


<210>  13605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13605
cucacucagu gcucaguguu                                                   20


<210>  13606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13606
gucugcaauc ccggcaccuc                                                   20


<210>  13607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13607
ggaggccgag gcuggcagau                                                   20


<210>  13608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13608
cgaggugccg ggauugcaga                                                   20


<210>  13609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13609
gccucccgag gugccgggau                                                   20


<210>  13610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13610
ugacugcaag ugaucugcca                                                   20


<210>  13611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13611
agcuccugac ugcaagugau                                                   20


<210>  13612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13612
accaaaaaac acgaaaacca                                                   20


<210>  13613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13613
gccugccaag ugccugggau                                                   20


<210>  13614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13614
ugccucagcc ugccaagugc                                                   20


<210>  13615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13615
cuaccugauu cuccugccuc                                                   20


<210>  13616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13616
cugcaaccuc ccuaccugau                                                   20


<210>  13617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13617
acucacugca accucccuac                                                   20


<210>  13618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13618
gcaucagagg gagacugugc                                                   20


<210>  13619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13619
gaugccgagc caaggcugga                                                   20


<210>  13620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13620
cucugaugcc gagccaaggc                                                   20


<210>  13621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13621
cacagucucc cucugaugcc                                                   20


<210>  13622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13622
cccucgcaca gucucccucu                                                   20


<210>  13623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13623
cccucgcccu cgcacagucu                                                   20


<210>  13624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13624
cccucgcccu cgcccucgca                                                   20


<210>  13625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13625
ggccucuaaa acugugaaag                                                   20


<210>  13626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13626
aaaacuguga aagaaaaaau                                                   20


<210>  13627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13627
uuuuuugguu cauuagcuau                                                   20


<210>  13628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13628
uccccuauuu cuggcuucuu                                                   20


<210>  13629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13629
uucuuuccuu uauuugccuc                                                   20


<210>  13630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13630
guauaugcug cugccugcaa                                                   20


<210>  13631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13631
ugcccaggau gagaugguca                                                   20


<210>  13632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13632
uccugggcaa gagccuuugc                                                   20


<210>  13633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13633
guaguccggu gcauaaacau                                                   20


<210>  13634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13634
aucacugugg auuugucugu                                                   20


<210>  13635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13635
caaugauuug uagaacacgu                                                   20


<210>  13636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13636
augauuugua gaacacguag                                                   20


<210>  13637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13637
uuggcauuua caggacacuc                                                   20


<210>  13638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13638
acccagcacc agcagaagag                                                   20


<210>  13639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13639
ucugcuggug cuggguggag                                                   20


<210>  13640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13640
cucaagugcu cacagaaugu                                                   20


<210>  13641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13641
caagugcuca cagaauguuu                                                   20


<210>  13642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13642
agugcucaca gaauguuugc                                                   20


<210>  13643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13643
cagaauguuu gccaagauag                                                   20


<210>  13644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13644
aucuuggcaa acauucugug                                                   20


<210>  13645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13645
aaauuaaaag cauucaaauu                                                   20


<210>  13646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13646
gaauaauuug aaugcuuuua                                                   20


<210>  13647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13647
guaucauuaa guuggaauau                                                   20


<210>  13648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13648
gauaugugga aaaacccauu                                                   20


<210>  13649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13649
gcuucuaccu uuggaaacuu                                                   20


<210>  13650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13650
ggauuccauu ugcuugucau                                                   20


<210>  13651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13651
caaaguggca gaacugcagg                                                   20


<210>  13652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13652
gccucccaaa guggcagaac                                                   20


<210>  13653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13653
aacaauccac cugccucggc                                                   20


<210>  13654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13654
cuaggcugcc caggcugguc                                                   20


<210>  13655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13655
ugguuagcug ggacuacagg                                                   20


<210>  13656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13656
caccuuagac uccugguuag                                                   20


<210>  13657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13657
agcaauccuc ccaccuuaga                                                   20


<210>  13658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13658
cagacucaag caauccuccc                                                   20


<210>  13659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13659
accucccaga cucaagcaau                                                   20


<210>  13660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13660
uucuguugcc caggauggaa                                                   20


<210>  13661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13661
aaaacaaaaa caguuacuag                                                   20


<210>  13662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13662
uaucuuuaug auguccauuc                                                   20


<210>  13663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13663
uuccugauau ugcuaauuug                                                   20


<210>  13664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13664
cucauuccug auauugcuaa                                                   20


<210>  13665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13665
uacaguccuu uuaauaucua                                                   20


<210>  13666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13666
caaggugcug ggauuacagg                                                   20


<210>  13667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13667
gccucccaag gugcugggau                                                   20


<210>  13668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13668
ggugaucugu ccaccucggc                                                   20


<210>  13669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13669
ugaccucagg ugaucugucc                                                   20


<210>  13670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13670
gucucuacua aaaauacaaa                                                   20


<210>  13671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13671
acuaaaaaua caaaaauuag                                                   20


<210>  13672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13672
caaguagcug ggauuacagg                                                   20


<210>  13673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13673
gccucccaag uagcugggau                                                   20


<210>  13674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13674
ugccucagcc ucccaaguag                                                   20


<210>  13675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13675
cagguucaag caauucuccu                                                   20


<210>  13676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13676
gccucccagg uucaagcaau                                                   20


<210>  13677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13677
cugcaaccuc cgccucccag                                                   20


<210>  13678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13678
gcucacugca accuccgccu                                                   20


<210>  13679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13679
agccugggug acagagcaag                                                   20


<210>  13680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13680
gucacccagg cuggagugca                                                   20


<210>  13681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13681
aucucaaaac aaauaaauaa                                                   20


<210>  13682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13682
aaacaaauaa auaaauaaaa                                                   20


<210>  13683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13683
uccauuucau cuauaaguug                                                   20


<210>  13684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13684
cucaagaaga uauagauaag                                                   20


<210>  13685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13685
caagaagaua uagauaagcu                                                   20


<210>  13686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13686
agaagauaua gauaagcuga                                                   20


<210>  13687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13687
auucagacac uaaauuuuca                                                   20


<210>  13688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13688
cauucuguuu cuguugacag                                                   20


<210>  13689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13689
aaagcaguac ugucaacaga                                                   20


<210>  13690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13690
guucguuauu cauggcuguc                                                   20


<210>  13691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13691
uaggcucauu gcuaucuucc                                                   20


<210>  13692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13692
uugcuaucuu ccaaccauug                                                   20


<210>  13693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13693
agguaaaaau ugcaaacaau                                                   20


<210>  13694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13694
uuaucucuag guaaaaauug                                                   20


<210>  13695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13695
uucucuuuau cucuagguaa                                                   20


<210>  13696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13696
gaaaccaaau gucucuuucu                                                   20


<210>  13697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13697
uucaugaucc caaucuaacu                                                   20


<210>  13698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13698
uuuugaugcu ucaaaaauag                                                   20


<210>  13699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13699
ucaguuuagc ucucucuugg                                                   20


<210>  13700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13700
cucuuggcuu uguuuagaca                                                   20


<210>  13701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13701
cuuggcuuug uuuagacagu                                                   20


<210>  13702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13702
uggcuuuguu uagacaguug                                                   20


<210>  13703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13703
aacugucuaa acaaagccaa                                                   20


<210>  13704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13704
aguuuuugug acucuuuguc                                                   20


<210>  13705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13705
uugucucgca caacaaaaac                                                   20


<210>  13706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13706
cacaacaaaa acacaaucug                                                   20


<210>  13707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13707
ugccccuuuu uaaucuugcu                                                   20


<210>  13708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13708
ccugccccuu uuuaaucuug                                                   20


<210>  13709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13709
uaaccuacaa uauucuugga                                                   20


<210>  13710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13710
uuuuucuuuu uaaauuuucg                                                   20


<210>  13711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13711
ucuuuuuuaa aaaauaaacu                                                   20


<210>  13712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13712
cacuaaauua ggaugauaau                                                   20


<210>  13713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13713
uuacauuuca uugucauguc                                                   20


<210>  13714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13714
ucuugacagu uucucuucuu                                                   20


<210>  13715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13715
ugacaguuuc ucuucuuuuu                                                   20


<210>  13716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13716
ucuuuuuuug cuuagaaauu                                                   20


<210>  13717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13717
agaauuucag aaacuucugg                                                   20


<210>  13718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13718
gcgucaucac ugcacagcag                                                   20


<210>  13719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13719
acaaaguuau caaaguaaga                                                   20


<210>  13720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13720
ucagagcuau cauuguugua                                                   20


<210>  13721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13721
gagcuaucau uguuguaggc                                                   20


<210>  13722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13722
gaggagaaca ucauccacac                                                   20


<210>  13723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13723
gccuacaaca augauagcuc                                                   20


<210>  13724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13724
cagccuacaa caaugauagc                                                   20


<210>  13725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13725
augaucgcuu cuucucucag                                                   20


<210>  13726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13726
aaacagaaga acacucaaug                                                   20


<210>  13727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13727
gggacucaaa acagaagaac                                                   20


<210>  13728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13728
aaaccauaca ucagaaagga                                                   20


<210>  13729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13729
guuguauggu uuggaggugc                                                   20


<210>  13730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13730
aaaccauaca acagagcacc                                                   20


<210>  13731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13731
guuguauggu uuggaggugc                                                   20


<210>  13732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13732
aaaccauaca acagagcacc                                                   20


<210>  13733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13733
auuguauggu uuggaggugc                                                   20


<210>  13734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13734
aaaccauaca auagagcacc                                                   20


<210>  13735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13735
guuguauggu uuggaggugc                                                   20


<210>  13736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13736
aaaccauaca acagagcacc                                                   20


<210>  13737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13737
uguaugguuu ggaggugcuc                                                   20


<210>  13738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13738
aaaccauaca agagcaccuc                                                   20


<210>  13739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13739
uguaugguuu ggaggugcuc                                                   20


<210>  13740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13740
aaaccauaca agagcaccuc                                                   20


<210>  13741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13741
guuguauggu uuggaggugg                                                   20


<210>  13742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13742
aaaccauaca acagagcacc                                                   20


<210>  13743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13743
auugcauggu uugcaggugc                                                   20


<210>  13744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13744
auuguauggu uuggaagugc                                                   20


<210>  13745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13745
uguaugguuu ggaggugcuc                                                   20


<210>  13746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13746
aaaccauaca agagcacuuc                                                   20


<210>  13747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13747
uguaugguuu ggagaugcuc                                                   20


<210>  13748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13748
aaaccauaca agagcaccuc                                                   20


<210>  13749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13749
auuguauggu uugcaggugc                                                   20


<210>  13750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13750
auuguauggu uuggaagugc                                                   20


<210>  13751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13751
uguaugguuu ggaggugcuc                                                   20


<210>  13752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13752
aaaccauaca agagcacuuc                                                   20


<210>  13753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13753
uguaugguuu ggaggugcuc                                                   20


<210>  13754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13754
aaaccauaca agagcaccuc                                                   20


<210>  13755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13755
guuguauggu uuggaggugc                                                   20


<210>  13756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13756
aaaccauaca acagagcacc                                                   20


<210>  13757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13757
guuguauggu uuggaggugc                                                   20


<210>  13758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13758
aaaccauaca acagagcacc                                                   20


<210>  13759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13759
uguaugguuu ggaggugcuc                                                   20


<210>  13760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13760
aaaccauaca agagcaccuc                                                   20


<210>  13761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13761
auuguauggu uuggagaugc                                                   20


<210>  13762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13762
aaaccauaca auagagcacc                                                   20


<210>  13763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13763
gguaucugcc ugcauugcuu                                                   20


<210>  13764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13764
ugggaaaaug ucacuacagg                                                   20


<210>  13765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13765
ggugccugua gugacauuuu                                                   20


<210>  13766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13766
ggcuucucug gugccuguag                                                   20


<210>  13767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13767
uagaaauuug ggcauagcuc                                                   20


<210>  13768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13768
guuuucuuaa ccauaaaaug                                                   20


<210>  13769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13769
uacacaugcc acaaaaacau                                                   20


<210>  13770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13770
cacauacaca gacacacacu                                                   20


<210>  13771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13771
cacauacaca auuuaauccu                                                   20


<210>  13772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13772
aagugguaag aaguguucuu                                                   20


<210>  13773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13773
uacccagcaa gauugauggg                                                   20


<210>  13774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13774
uuuuccauca caugguuucc                                                   20


<210>  13775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13775
ggagccaugg gauucuagcu                                                   20


<210>  13776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13776
agagaagcca gcguccugac                                                   20


<210>  13777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13777
cugucuuguc ccuagagugg                                                   20


<210>  13778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13778
agggacaaga cagggagcua                                                   20


<210>  13779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13779
cuccgcuugc aauuccugcu                                                   20


<210>  13780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13780
ccgcuugcaa uuccugcuuu                                                   20


<210>  13781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13781
gcuugcaauu ccugcuuugc                                                   20


<210>  13782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13782
caucucacuu augcagugac                                                   20


<210>  13783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13783
cuuaugcagu gacguauauc                                                   20


<210>  13784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13784
gugccugcug aucauuggca                                                   20


<210>  13785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13785
acaggccuaa auauccuugc                                                   20


<210>  13786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13786
cuggcaggac cagggcgguc                                                   20


<210>  13787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13787
ugcaaagaca gaccgcccug                                                   20


<210>  13788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13788
cucagucacc caggcuggag                                                   20


<210>  13789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13789
gucacccagg cuggagugca                                                   20


<210>  13790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13790
agccugggug acugagcgag                                                   20


<210>  13791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13791
uugcagccuu gagcuaccgg                                                   20


<210>  13792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13792
aggcugcaau gagccgugau                                                   20


<210>  13793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13793
agcuauccuc cuggcuuggc                                                   20


<210>  13794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13794
uggcuuggcc ccuugaguag                                                   20


<210>  13795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13795
aggggccaag ccaggaggau                                                   20


<210>  13796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13796
acaaauaauu uuaaaaauua                                                   20


<210>  13797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13797
ccagguugcc caggcugguc                                                   20


<210>  13798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13798
agugauccuc ccuccuuggu                                                   20


<210>  13799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13799
cuccuugguu ucccaaagug                                                   20


<210>  13800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13800
uugguuuccc aaagugcugg                                                   20


<210>  13801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13801
caccugugau cccagcacuu                                                   20


<210>  13802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13802
gagucagaaa aucuaaaaag                                                   20


<210>  13803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13803
gaggaucaaa uaucaagaac                                                   20


<210>  13804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13804
uuuuagauuu ucugacucug                                                   20


<210>  13805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13805
uaacguccca uuugccauga                                                   20


<210>  13806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13806
gcccucuuaa cgucccauuu                                                   20


<210>  13807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13807
cugcccucuu aacgucccau                                                   20


<210>  13808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13808
uucauuuuuu uuccaggaau                                                   20


<210>  13809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13809
gacacacacc aagccacugu                                                   20


<210>  13810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13810
ggugcucuuc cuggcugucu                                                   20


<210>  13811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13811
uccuggcugu cuccuugcuu                                                   20


<210>  13812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13812
uugcuucuuu cccauguccu                                                   20


<210>  13813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13813
ucuuuguuuc cagccauuuc                                                   20


<210>  13814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13814
cuuaugcuua aguuuggugc                                                   20


<210>  13815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13815
cagauuccug cuuccucaga                                                   20


<210>  13816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13816
gauuccugcu uccucagaug                                                   20


<210>  13817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13817
gaugcuguag uugucaggcc                                                   20


<210>  13818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13818
cacuguggca gaguaggggg                                                   20


<210>  13819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13819
cuguggcaga guagggggag                                                   20


<210>  13820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13820
gccacaguga gagcaaaccu                                                   20


<210>  13821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13821
cccuacucug ccacagugag                                                   20


<210>  13822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13822
cacgccuccc ccuacucugc                                                   20


<210>  13823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13823
cccacgccuc ccccuacucu                                                   20


<210>  13824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13824
cuacagcugg ccugggguca                                                   20


<210>  13825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13825
ugaguauggc ugugugugua                                                   20


<210>  13826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13826
ugagaagaca aagucuagga                                                   20


<210>  13827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13827
acagaaacca caugcaaaau                                                   20


<210>  13828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13828
cucagguagg uuagucucag                                                   20


<210>  13829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13829
gguagguuag ucucaggcgg                                                   20


<210>  13830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13830
ggcggugaag cacguguguc                                                   20


<210>  13831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13831
guucugugag gugcuggcaa                                                   20


<210>  13832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13832
cagaacggag acuuuaugcc                                                   20


<210>  13833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13833
ugacgguggu ggugauuugc                                                   20


<210>  13834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13834
cuagacaaaa aucacuucag                                                   20


<210>  13835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13835
aggaagccuu uccugccucc                                                   20


<210>  13836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13836
uucaccuacu ggcugcugac                                                   20


<210>  13837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13837
aaucuacucu uucaccuacu                                                   20


<210>  13838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13838
ugucucaagg ggugccagga                                                   20


<210>  13839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13839
aggggugcca ggaagcugug                                                   20


<210>  13840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13840
acagcuuccu ggcaccccuu                                                   20


<210>  13841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13841
ggcagcauaa gauggguuca                                                   20


<210>  13842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13842
cuggcagcau aagauggguu                                                   20


<210>  13843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13843
ugguguccca cucucuggca                                                   20


<210>  13844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13844
accaaacaag guacaacccc                                                   20


<210>  13845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13845
ugaagacuuu ggaugugguc                                                   20


<210>  13846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13846
ccugaccaca uccaaagucu                                                   20


<210>  13847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13847
uccuaaauga uacacucccc                                                   20


<210>  13848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13848
ccgggucacu cuuccuaaau                                                   20


<210>  13849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13849
accccacguc cucaccgggu                                                   20


<210>  13850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13850
ucuaccccac guccucaccg                                                   20


<210>  13851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13851
caccuguccu ccucuacccc                                                   20


<210>  13852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13852
cucccaccug uccuccucua                                                   20


<210>  13853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13853
caccuggacu cccucccacc                                                   20


<210>  13854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13854
cucccaccug gacucccucc                                                   20


<210>  13855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13855
ugcugggucu acucacuccc                                                   20


<210>  13856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13856
agccaggaug guggcagggc                                                   20


<210>  13857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13857
aggcccugca cuccugcugg                                                   20


<210>  13858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13858
cagcccugcc accauccugg                                                   20


<210>  13859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13859
ucacagcccu gccaccaucc                                                   20


<210>  13860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13860
ccucacagcc cugccaccau                                                   20


<210>  13861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13861
ugccccugcu uccgcagaca                                                   20


<210>  13862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13862
ucccucuugc cccugcuucc                                                   20


<210>  13863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13863
caaucuacgc cagucgcugg                                                   20


<210>  13864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13864
cacaaucuac gccagucgcu                                                   20


<210>  13865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13865
uaggaggggc ugaguuuuag                                                   20


<210>  13866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13866
uaagagcagg gaauggucuc                                                   20


<210>  13867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13867
gccccuccua agagcaggga                                                   20


<210>  13868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13868
uguuauacaa uaagcuuggu                                                   20


<210>  13869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13869
uuuaaggacu uucaguacaa                                                   20


<210>  13870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13870
gaaacguuua aauccuaauc                                                   20


<210>  13871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13871
ucagaauuuc ccagaaugug                                                   20


<210>  13872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13872
gaauuuccca gaaugugauc                                                   20


<210>  13873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13873
guccacuuac aucaacugcc                                                   20


<210>  13874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13874
uuaaccgugg caugggcagu                                                   20


<210>  13875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13875
cucuugggug ggcaagcauu                                                   20


<210>  13876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13876
ugggugggca agcauuugga                                                   20


<210>  13877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13877
uccaaaugcu ugcccaccca                                                   20


<210>  13878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13878
uaugggugag aguggggcac                                                   20


<210>  13879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13879
cccauaggag ccuucucuuc                                                   20


<210>  13880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13880
cacccauagg agccuucucu                                                   20


<210>  13881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13881
agcuagggga ugggacaggg                                                   20


<210>  13882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13882
aauguggacu uugugccguu                                                   20


<210>  13883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13883
caagugagca aggaggguug                                                   20


<210>  13884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13884
cuugugaggc uaaaccagaa                                                   20


<210>  13885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13885
uugcucacuu gugaggcuaa                                                   20


<210>  13886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13886
acccuccuug cucacuugug                                                   20


<210>  13887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13887
caacccuccu ugcucacuug                                                   20


<210>  13888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13888
cagcacaucu cucaacccuc                                                   20


<210>  13889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13889
gggucagggg ggcagggacc                                                   20


<210>  13890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13890
cugucaggua ugcccguggu                                                   20


<210>  13891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13891
ucacugucag guaugcccgu                                                   20


<210>  13892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13892
gccuugggaa guguucuagg                                                   20


<210>  13893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13893
ggccuagaac acuucccaag                                                   20


<210>  13894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13894
cucuggccua gaacacuucc                                                   20


<210>  13895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13895
ggacccugca gauguccagg                                                   20


<210>  13896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13896
gacggcaccc uggacaucug                                                   20


<210>  13897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13897
aggggcuuua ggauuuauua                                                   20


<210>  13898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13898
aaaaaaaaaa aaaaaaaaau                                                   20


<210>  13899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13899
aucucaaaaa aaaaaaaaaa                                                   20


<210>  13900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13900
uguugcccag gcuggagugc                                                   20


<210>  13901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13901
agccugggca acaagagcga                                                   20


<210>  13902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13902
cugcaaccuc cgccucccgg                                                   20


<210>  13903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13903
gccucccggg uucaaacuau                                                   20


<210>  13904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13904
cggguucaaa cuauucuccu                                                   20


<210>  13905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13905
ugccucagcc ucucgaguag                                                   20


<210>  13906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13906
gccucucgag uagcugggau                                                   20


<210>  13907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13907
cgaguagcug ggauuacagg                                                   20


<210>  13908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13908
aguagcuggg auuacaggcg                                                   20


<210>  13909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13909
agaggcugag gcaggagaau                                                   20


<210>  13910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13910
acuaaaaaau acaaaaauua                                                   20


<210>  13911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13911
gucucuacua aaaaauacaa                                                   20


<210>  13912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13912
auguugguca ggcuggucuu                                                   20


<210>  13913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13913
ugaccucagg ugaucugccc                                                   20


<210>  13914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13914
ggugaucugc ccgccuuggc                                                   20


<210>  13915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13915
caaagugcug ggauuacagg                                                   20


<210>  13916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13916
ugccuguaau cccagcacuu                                                   20


<210>  13917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13917
uuuuagaacu agugauggga                                                   20


<210>  13918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13918
ugugauuugu uguaggcuuu                                                   20


<210>  13919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13919
agcucuauaa ggaaauuaaa                                                   20


<210>  13920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13920
agcuguaacc uuggaagauu                                                   20


<210>  13921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13921
auaaggaaau uaaaaaggug                                                   20


<210>  13922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13922
uguaccccau aaauauauac                                                   20


<210>  13923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13923
agcauuuauc cuuuguguua                                                   20


<210>  13924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13924
aaaauaaaau aaaauaagua                                                   20


<210>  13925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13925
gucucaaaaa uaaaauaaaa                                                   20


<210>  13926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13926
agcaugggug aaagcaagac                                                   20


<210>  13927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13927
cugcaaccuc cgccucccgg                                                   20


<210>  13928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13928
gccucccggg uucaaccgaa                                                   20


<210>  13929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13929
cggguucaac cgaacuuugg                                                   20


<210>  13930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13930
aacuccugac cucaggugau                                                   20


<210>  13931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13931
ugaccucagg ugauccgccc                                                   20


<210>  13932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13932
ggugauccgc ccgccucggc                                                   20


<210>  13933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13933
gccucccaaa guguugggau                                                   20


<210>  13934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13934
caaaguguug ggauuacagg                                                   20


<210>  13935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13935
cgccuguaau cccaacacuu                                                   20


<210>  13936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13936
ugccuguaau cccagcauuu                                                   20


<210>  13937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13937
caaaaugcug ggauuacagg                                                   20


<210>  13938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13938
gccucccaaa augcugggau                                                   20


<210>  13939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13939
ggugaucacc ugccucagcc                                                   20


<210>  13940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13940
ugaucucagg ugaucaccug                                                   20


<210>  13941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13941
aacuccugau cucaggugau                                                   20


<210>  13942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13942
auguuggcca ggcuggucuc                                                   20


<210>  13943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13943
acuaaaaaua caaaaauuag                                                   20


<210>  13944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13944
ggaggcugag guaggggaau                                                   20


<210>  13945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13945
cgaguagcca ggauuacagg                                                   20


<210>  13946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13946
gccucccgag uagccaggau                                                   20


<210>  13947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13947
acccccaggu ucaagcgauu                                                   20


<210>  13948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13948
cugcaaccuc cacccccagg                                                   20


<210>  13949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13949
gcucacugca accuccaccc                                                   20


<210>  13950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13950
ggcuggaaug caguggcgug                                                   20


<210>  13951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13951
gucgcucagg cuggaaugca                                                   20


<210>  13952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13952
cucugucgcu caggcuggaa                                                   20


<210>  13953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13953
aaaaauaaaa augaaauaaa                                                   20


<210>  13954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13954
caccuuaguc ccagcacuuu                                                   20


<210>  13955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13955
gguucccaaa gugcugggac                                                   20


<210>  13956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13956
agcauccacc ugccucaggu                                                   20


<210>  13957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13957
uggucucaag cauccaccug                                                   20


<210>  13958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13958
aacuccuggu cucaagcauc                                                   20


<210>  13959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13959
gcuacuuggg agauugaggu                                                   20


<210>  13960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13960
caaguagcug agacuauagu                                                   20


<210>  13961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13961
aucucccaag uagcugagac                                                   20


<210>  13962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13962
caccucaauc ucccaaguag                                                   20


<210>  13963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13963
auuaauccuc ccaccucaau                                                   20


<210>  13964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13964
gcuaccuaua gauucaaccu                                                   20


<210>  13965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13965
cuuggucgcc caggcugaag                                                   20


<210>  13966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13966
aaagaaaaac aaaaaaacaa                                                   20


<210>  13967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13967
gcugugcugu cgaauaccag                                                   20


<210>  13968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13968
gugauggaaa uaagggccca                                                   20


<210>  13969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13969
guuaagcagc agguguggga                                                   20


<210>  13970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13970
uuauuagaug agaugagaau                                                   20


<210>  13971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13971
ucuaauaaag aguaaccuuu                                                   20


<210>  13972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13972
ucucaucuaa uaaagaguaa                                                   20


<210>  13973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13973
aaaauuagaa aguaacaagg                                                   20


<210>  13974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13974
uggugacuag uaugugacuc                                                   20


<210>  13975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13975
uaaugcaacc cucauugcac                                                   20


<210>  13976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13976
uugcaccccc ucagaauggu                                                   20


<210>  13977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13977
gaauggugcc ccucggaguu                                                   20


<210>  13978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13978
gaguuugcgu gcugcccugu                                                   20


<210>  13979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13979
gaggggcacc auucugaggg                                                   20


<210>  13980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13980
acagggcagc acgcaaacuc                                                   20


<210>  13981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13981
gcaaaccucc acagggcagc                                                   20


<210>  13982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13982
ccugguucgg ccucagaaau                                                   20


<210>  13983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13983
gaaaugcagg uaaguuguac                                                   20


<210>  13984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13984
ggauguuggu uuuugucggg                                                   20


<210>  13985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13985
gcucagaugu cauuucaaaa                                                   20


<210>  13986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13986
gaugucauuu caaaagucug                                                   20


<210>  13987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13987
gcccucucca aauugcaguc                                                   20


<210>  13988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13988
ccaaauugca gucgaccuug                                                   20


<210>  13989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13989
aaauugcagu cgaccuugcc                                                   20


<210>  13990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13990
uagcacuaau ccaugucaga                                                   20


<210>  13991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13991
ugcggaaggg ugggauagaa                                                   20


<210>  13992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13992
guugcagccc agcagcgaua                                                   20


<210>  13993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13993
accuucaaca auuuggcaag                                                   20


<210>  13994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13994
uauagucagc aauaaugaaa                                                   20


<210>  13995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13995
uguaacagac aaauggauau                                                   20


<210>  13996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13996
auccguuaag auacaacugu                                                   20


<210>  13997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13997
cuccuucucc uuaaccagca                                                   20


<210>  13998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13998
uucuccuuaa ccagcaauac                                                   20


<210>  13999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  13999
uuaaccagca auacaugcug                                                   20


<210>  14000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14000
gcuccauccu gagucacugg                                                   20


<210>  14001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14001
auccugaguc acugggaaug                                                   20


<210>  14002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14002
ggauggagcu gagggucuau                                                   20


<210>  14003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14003
cuauuaauau gaacugaguu                                                   20


<210>  14004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14004
guucauauua auagugaggg                                                   20


<210>  14005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14005
uaccuuugau cccagcacuu                                                   20


<210>  14006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14006
ugaagugcug ggaucaaagg                                                   20


<210>  14007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14007
acaaaaaaua caaaacuuag                                                   20


<210>  14008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14008
agaggcugag gugggaggau                                                   20


<210>  14009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14009
aguggcugug accacaggca                                                   20


<210>  14010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14010
cgaguggcug ugaccacagg                                                   20


<210>  14011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14011
gccucucgag uggcugugac                                                   20


<210>  14012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14012
caccucagcc ucucgagugg                                                   20


<210>  14013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14013
agugauccuc ccaccucagc                                                   20


<210>  14014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14014
caggcucaag ugauccuccc                                                   20


<210>  14015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14015
accucccagg cucaagugau                                                   20


<210>  14016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14016
acacgaccuc caccucccag                                                   20


<210>  14017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14017
agccugggca acagagugag                                                   20


<210>  14018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14018
guugcccagg cuggagugca                                                   20


<210>  14019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14019
cucuguugcc caggcuggag                                                   20


<210>  14020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14020
aaaaaaccaa aauccagaaa                                                   20


<210>  14021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14021
gcagccauau aaguucuuuu                                                   20


<210>  14022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14022
uguacccauu ucccagugcc                                                   20


<210>  14023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14023
aucuaaacgg cacugggaaa                                                   20


<210>  14024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14024
ucaauggcuc ugucaccuca                                                   20


<210>  14025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14025
gucaccucag acacccugca                                                   20


<210>  14026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14026
gacacccugc auugacucau                                                   20


<210>  14027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14027
uuagucugau uagagucagg                                                   20


<210>  14028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14028
aaucagacua augagucaau                                                   20


<210>  14029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14029
ugaugguuuu uuuuuccccc                                                   20


<210>  14030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14030
gcggaacagu cacuuccuua                                                   20


<210>  14031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14031
cuaaggaagu gacuguuccg                                                   20


<210>  14032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14032
gaggccgugc uuguugccag                                                   20


<210>  14033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14033
gaggguggcu ggggaaaccu                                                   20


<210>  14034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14034
gccacuagag ggcagggcug                                                   20


<210>  14035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14035
aguggcagag ucuggcaaca                                                   20


<210>  14036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14036
uggcaccucg cacccggccu                                                   20


<210>  14037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14037
cacccggccu gcccugucac                                                   20


<210>  14038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14038
guguguuggg ugaauuccug                                                   20


<210>  14039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14039
cugcucugug uccuacacau                                                   20


<210>  14040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14040
guguccuaca cauucggcuu                                                   20


<210>  14041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14041
ccccacaacc ccauuuuaua                                                   20


<210>  14042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14042
ccacaacccc auuuuauaau                                                   20


<210>  14043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14043
uuuuucagga aagcuuuauu                                                   20


<210>  14044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14044
uuuuuaauua gaaaauaagu                                                   20


<210>  14045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14045
gugaucauaa gagaaaugaa                                                   20


<210>  14046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14046
uaugaucaca gaggaucuaa                                                   20


<210>  14047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14047
caacacuuga gcuucaucca                                                   20


<210>  14048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14048
aguguuggga gacauccuuc                                                   20


<210>  14049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14049
uguucuuuca gcugaguuuu                                                   20


<210>  14050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14050
gcugaaagaa caggaggaug                                                   20


<210>  14051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14051
ugaaggagag cuggaagaau                                                   20


<210>  14052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14052
uucaggagaa acagaagcaa                                                   20


<210>  14053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14053
ccuucaggag aaacagaagc                                                   20


<210>  14054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14054
aacaagcaag agacccgaag                                                   20


<210>  14055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14055
ugcuuguucg agucaggcac                                                   20


<210>  14056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14056
uggacugauu cuucgggucu                                                   20


<210>  14057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14057
ggucacaaac augcgaguga                                                   20


<210>  14058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14058
cauguuugug accugaggca                                                   20


<210>  14059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14059
cagcaucacu cgcauguuug                                                   20


<210>  14060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14060
cucacagcau cacucgcaug                                                   20


<210>  14061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14061
acagacucac ucacagcauc                                                   20


<210>  14062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14062
cccuccacag acucacucac                                                   20


<210>  14063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14063
cuguucagaa gcccucaccc                                                   20


<210>  14064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14064
cacaggacuc ccuguucaga                                                   20


<210>  14065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14065
aaaauaacac aaaugauggu                                                   20


<210>  14066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14066
uuucuuacug uggggugaag                                                   20


<210>  14067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14067
ucaccccaca guaagaaaug                                                   20


<210>  14068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14068
caauucaacu cuucacccca                                                   20


<210>  14069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14069
ggaaaaaugc cuuuucaauu                                                   20


<210>  14070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14070
aguacgccga aaacaaaucu                                                   20


<210>  14071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14071
uuaaccuagc ugcgggaaga                                                   20


<210>  14072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14072
uaccugcagu cuuggcacag                                                   20


<210>  14073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14073
cugacgaggc cuuguggguc                                                   20


<210>  14074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14074
ucagugagcu uucuccuacc                                                   20


<210>  14075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14075
gauagcugca ggacguucag                                                   20


<210>  14076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14076
acagauuaca ggauucuuag                                                   20


<210>  14077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14077
uccuuuuugg uaggucaguc                                                   20


<210>  14078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14078
aacccaggac ugaccuacca                                                   20


<210>  14079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14079
ugggagguga ugauacacac                                                   20


<210>  14080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14080
caggaggguc acuugggcuc                                                   20


<210>  14081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14081
acccagugug uaucaucacc                                                   20


<210>  14082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14082
uuacuaguua uuuuccucua                                                   20


<210>  14083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14083
aggcaaacug cccaacagcu                                                   20


<210>  14084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14084
aagcuauuuc cuucguauuc                                                   20


<210>  14085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14085
gagaguaaaa uaaaggaaua                                                   20


<210>  14086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14086
gaguugcccu auaugggucc                                                   20


<210>  14087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14087
cagaguugcc cuauaugggu                                                   20


<210>  14088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14088
aacacauauu ccuuuauuuu                                                   20


<210>  14089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14089
uauuagcuga augauuugga                                                   20


<210>  14090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14090
cucauguuuu uucucuugag                                                   20


<210>  14091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14091
cauguuuuuu cucuugagcu                                                   20


<210>  14092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14092
uguuuuuucu cuugagcuuc                                                   20


<210>  14093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14093
ugagcuucga aguuuucuug                                                   20


<210>  14094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14094
agagaaaaaa caugagagag                                                   20


<210>  14095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14095
uuaguauuaa caagaaaacu                                                   20


<210>  14096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14096
cuucgucauu ccaaaacccc                                                   20


<210>  14097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14097
guaaauggua guuucugcug                                                   20


<210>  14098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14098
uuggaauggg aguaggugcu                                                   20


<210>  14099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14099
cauuccaaag agaugguaau                                                   20


<210>  14100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14100
uuugugguca gaggcuguga                                                   20


<210>  14101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14101
gaccacaaag gagcaccuac                                                   20


<210>  14102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14102
cagccucuga ccacaaagga                                                   20


<210>  14103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14103
cacagccucu gaccacaaag                                                   20


<210>  14104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14104
acagcgccag uuugcccauc                                                   20


<210>  14105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14105
gugauaucuc uggcugucag                                                   20


<210>  14106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14106
ggcugucaga gcucagauga                                                   20


<210>  14107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14107
gacagccaga gauaucacag                                                   20


<210>  14108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14108
gaugauagau gguauuuuug                                                   20


<210>  14109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14109
uaguucucau cauuuucaug                                                   20


<210>  14110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14110
ucauuuucau gauuucgauc                                                   20


<210>  14111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14111
aauggugauc gaaaucauga                                                   20


<210>  14112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14112
cugcucauuu augguuauuc                                                   20


<210>  14113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14113
gcucauuuau gguuauucaa                                                   20


<210>  14114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14114
uuuaugguua uucaaauuua                                                   20


<210>  14115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14115
ugauaauaaa uuugaauaac                                                   20


<210>  14116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14116
caaguagcua caauuauagg                                                   20


<210>  14117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14117
gccucccaag uagcuacaau                                                   20


<210>  14118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14118
uaccucagcc ucccaaguag                                                   20


<210>  14119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14119
agcaauccuc cuaccucagc                                                   20


<210>  14120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14120
uggccucaag caauccuccu                                                   20


<210>  14121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14121
aacuccuggc cucaagcaau                                                   20


<210>  14122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14122
cuaucuugcc caggcugguc                                                   20


<210>  14123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14123
aaaaaaacug aaaaaaaauu                                                   20


<210>  14124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14124
ggaggcugag acaggaggcu                                                   20


<210>  14125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14125
ugaguagcua ggaccacagg                                                   20


<210>  14126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14126
gccuccugag uagcuaggac                                                   20


<210>  14127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14127
ugucucagcc uccugaguag                                                   20


<210>  14128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14128
guugagccca ggaguuggag                                                   20


<210>  14129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14129
accgagccuc cugucucagc                                                   20


<210>  14130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14130
ugggcucaac cgagccuccu                                                   20


<210>  14131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14131
aacuccuggg cucaaccgag                                                   20


<210>  14132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14132
aacuccaacu ccugggcuca                                                   20


<210>  14133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14133
guguagccuc gaacuccaac                                                   20


<210>  14134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14134
agcaugggug guaaaacaag                                                   20


<210>  14135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14135
uaauccuugu gucucacagg                                                   20


<210>  14136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14136
caggcaaaca uaacucuuag                                                   20


<210>  14137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14137
uaguauuucu uccaauauuu                                                   20


<210>  14138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14138
aagaaaaaaa aagaaagaaa                                                   20


<210>  14139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14139
aucucaaaga aaaaaaaaga                                                   20


<210>  14140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14140
uguugccaag gcuggagugc                                                   20


<210>  14141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14141
agccuuggca acaagagcaa                                                   20


<210>  14142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14142
ccacaaccuc ugucucccgg                                                   20


<210>  14143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14143
gucucccggg uucaagcgau                                                   20


<210>  14144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14144
cggguucaag cgauucuccu                                                   20


<210>  14145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14145
ugccucagcc uccuaguagc                                                   20


<210>  14146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14146
gccuccuagu agcugggauu                                                   20


<210>  14147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14147
uaguagcugg gauuacaggc                                                   20


<210>  14148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14148
gcuaauuuug uacuuuuagu                                                   20


<210>  14149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14149
acuaaaagua caaaauuagc                                                   20


<210>  14150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14150
ggguugguca ggcuggucuc                                                   20


<210>  14151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14151
aacuccugac cucaggugau                                                   20


<210>  14152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14152
ugaccucagg ugauccuccc                                                   20


<210>  14153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14153
ggugauccuc ccaccucagc                                                   20


<210>  14154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14154
caccucagcc ucccaaagug                                                   20


<210>  14155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14155
gccucccaaa gugcugggau                                                   20


<210>  14156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14156
caaagugcug ggauuacagg                                                   20


<210>  14157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14157
cgccuguaau cccagcacuu                                                   20


<210>  14158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14158
ucaaauaaga aacacaauca                                                   20


<210>  14159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14159
ggguugaaac uggagagagg                                                   20


<210>  14160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14160
aguuucaacc cagagcaaaa                                                   20


<210>  14161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14161
ccaguuucaa cccagagcaa                                                   20


<210>  14162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14162
cuccaguuuc aacccagagc                                                   20


<210>  14163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14163
ccagguccuc ucuccaguuu                                                   20


<210>  14164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14164
uccccagguc cucucuccag                                                   20


<210>  14165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14165
uccuccccag guccucucuc                                                   20


<210>  14166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14166
uccuccuccc cagguccucu                                                   20


<210>  14167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14167
gcacccgggg aucugcugau                                                   20


<210>  14168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14168
uaggccaggc cccuaucgaa                                                   20


<210>  14169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14169
augauuagac cuugcaggug                                                   20


<210>  14170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14170
aagaugccuu ccuaaggaug                                                   20


<210>  14171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14171
accuccaaga ugccuuccua                                                   20


<210>  14172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14172
uccaccucca agaugccuuc                                                   20


<210>  14173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14173
gacccugguu ccuuucagag                                                   20


<210>  14174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14174
gaaaggaacc agggucugag                                                   20


<210>  14175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14175
uugcuggcuu gugccuugau                                                   20


<210>  14176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14176
aggaaaacaa aaaguuguac                                                   20


<210>  14177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14177
aagaaaacag augugaagau                                                   20


<210>  14178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14178
auaucgcuug cuuauuauuc                                                   20


<210>  14179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14179
caccuuccaa cuucuuugua                                                   20


<210>  14180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14180
aguuggauga ccacacuggg                                                   20


<210>  14181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14181
cugccccagu cugggcaggu                                                   20


<210>  14182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14182
gccccagucu gggcagguug                                                   20


<210>  14183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14183
uugccauuag ccuggaauuu                                                   20


<210>  14184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14184
cguuggaugc ccaguuccua                                                   20


<210>  14185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14185
ggaagcuacu agacgauaga                                                   20


<210>  14186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14186
caggaagcua cuagacgaua                                                   20


<210>  14187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14187
cauucaucuu cucucaggaa                                                   20


<210>  14188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14188
uacaauuucc cucccauuca                                                   20


<210>  14189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14189
gaaaugcaaa gucuuugccc                                                   20


<210>  14190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14190
aacgugaccc gauuccuuaa                                                   20


<210>  14191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14191
ccaaaaaugg aaagcuucca                                                   20


<210>  14192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14192
gagaaguucu ugccuuuuau                                                   20


<210>  14193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14193
gagaaauguu aagaaaauuu                                                   20


<210>  14194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14194
ccugaaauug guuaguugga                                                   20


<210>  14195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14195
ugaaauuggu uaguuggaug                                                   20


<210>  14196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14196
uagauugacu cacaucuuac                                                   20


<210>  14197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14197
caucuuaccu uuuucuuuuc                                                   20


<210>  14198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14198
aacucuucua uucauuguua                                                   20


<210>  14199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14199
ucuauucauu guuauguuuu                                                   20


<210>  14200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14200
ugaugggguc uugcccuguu                                                   20


<210>  14201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14201
cugcagccuc aaauuccugg                                                   20


<210>  14202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14202
aauuccuggg cucaagcagc                                                   20


<210>  14203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14203
agcagcuguu cugccucacc                                                   20


<210>  14204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14204
cccucccaag uaguugggac                                                   20


<210>  14205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14205
caaguaguug ggacuacagg                                                   20


<210>  14206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14206
aaaaaaaaaa aaaaaaagua                                                   20


<210>  14207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14207
aucucaaaaa aaaaaaaaaa                                                   20


<210>  14208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14208
gucgcccagg cuagagugcg                                                   20


<210>  14209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14209
agccugggcg acagaguagg                                                   20


<210>  14210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14210
cuuaagccuc ugccucccag                                                   20


<210>  14211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14211
gccucccagg uucaagcagu                                                   20


<210>  14212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14212
cagguucaag caguucuccu                                                   20


<210>  14213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14213
ugccucagcc ucucaaguag                                                   20


<210>  14214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14214
gccucucaag uagcugggau                                                   20


<210>  14215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14215
caaguagcug ggauuacagg                                                   20


<210>  14216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14216
aguagcuggg auuacaggug                                                   20


<210>  14217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14217
acuaaaaaua caaaaauuag                                                   20


<210>  14218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14218
ggcucuacua aaaauacaaa                                                   20


<210>  14219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14219
aacgccugac cucaggugau                                                   20


<210>  14220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14220
ggugauccgc cugccuuggc                                                   20


<210>  14221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14221
gaaagugccg ggauuacagg                                                   20


<210>  14222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14222
cgccuguaau cccggcacuu                                                   20


<210>  14223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14223
ugagucagcu aguaucccug                                                   20


<210>  14224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14224
agaggaaaag acuuauagau                                                   20


<210>  14225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14225
uuuuccugcu uggaggcuau                                                   20


<210>  14226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14226
aagcaggaaa augaguaauu                                                   20


<210>  14227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14227
cuuccagucc ccgguugcag                                                   20


<210>  14228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14228
uacuuuuugu uuucugugug                                                   20


<210>  14229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14229
cgucuguccu cagccuaugu                                                   20


<210>  14230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14230
gccuauguaa acaccucuug                                                   20


<210>  14231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14231
ugagauuauc ccucucaauc                                                   20


<210>  14232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14232
agagguguuu acauaggcug                                                   20


<210>  14233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14233
caaucuuugc cggagguggg                                                   20


<210>  14234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14234
aucuuugccg gagguggggg                                                   20


<210>  14235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14235
ggcaaagauu gagagggaua                                                   20


<210>  14236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14236
cccaccuccg gcaaagauug                                                   20


<210>  14237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14237
aauccaaggc agcccaggaa                                                   20


<210>  14238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14238
ggugaguggg ugggaauuug                                                   20


<210>  14239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14239
ccugaggucu ucccuccaau                                                   20


<210>  14240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14240
uugggcaaau ucccacccac                                                   20


<210>  14241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14241
uggcuccuug ggcaaauucc                                                   20


<210>  14242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14242
ccaucccucc acuuucagau                                                   20


<210>  14243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14243
aucccuccac uuucagaugu                                                   20


<210>  14244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14244
acuuucagau guauguggcg                                                   20


<210>  14245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14245
aaagcccgag cucuucuugg                                                   20


<210>  14246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14246
ggcuuuggag gcgccacaua                                                   20


<210>  14247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14247
ucuuggcguc uguggcuuca                                                   20


<210>  14248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14248
uacccucccc uguccccagc                                                   20


<210>  14249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14249
ccugucccca gcaaagcuug                                                   20


<210>  14250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14250
uguuacuuuu uagcuuccga                                                   20


<210>  14251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14251
gcuacccaga aaccccacaa                                                   20


<210>  14252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14252
cacccucugg uuuauucuua                                                   20


<210>  14253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14253
gguuuauucu uauucucaaa                                                   20


<210>  14254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14254
aaauuaccug ccaaacacug                                                   20


<210>  14255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14255
cuuguuuuuc cuuuuccuga                                                   20


<210>  14256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14256
gaagccucuc cccuauuccc                                                   20


<210>  14257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14257
ccccuauucc cccgucacug                                                   20


<210>  14258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14258
ccuauucccc cgucacugcu                                                   20


<210>  14259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14259
ugccuuccuc cccaagguca                                                   20


<210>  14260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14260
ccaaggucau gacugcuggc                                                   20


<210>  14261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14261
ggaauuagaa gccagcaguc                                                   20


<210>  14262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14262
ugaacuuaau gucgaccaaa                                                   20


<210>  14263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14263
caugaacuua augucgacca                                                   20


<210>  14264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14264
uaaaacuaca ggaauacuaa                                                   20


<210>  14265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14265
caauagccaa gaacuagaaa                                                   20


<210>  14266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14266
uagguguguc uuuuggagua                                                   20


<210>  14267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14267
aaaagacaca ccuaagagug                                                   20


<210>  14268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14268
agcugugcaa gauggaaacc                                                   20


<210>  14269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14269
accucuagcu gugcaagaug                                                   20


<210>  14270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14270
gcugcaguag aaacugccaa                                                   20


<210>  14271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14271
aggaaagcua uuuggcaguu                                                   20


<210>  14272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14272
cccuuuugcc acuguguaug                                                   20


<210>  14273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14273
uggaaucccc auacacagug                                                   20


<210>  14274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14274
gguccucgcu agcacuugga                                                   20


<210>  14275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14275
cuagcacuug gaauugcuga                                                   20


<210>  14276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14276
uagccuuccu gauggguguu                                                   20


<210>  14277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14277
gaaguuuaau gauucaugca                                                   20


<210>  14278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14278
ucccuuuuga aguacucuua                                                   20


<210>  14279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14279
uacagguaug uugugcaugu                                                   20


<210>  14280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14280
ucuguguuug aacaguugua                                                   20


<210>  14281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14281
guguuugaac aguuguagcg                                                   20


<210>  14282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14282
uguuagcugg cuuggagaag                                                   20


<210>  14283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14283
aagccagcua acaggaggcc                                                   20


<210>  14284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14284
acaaucccaa gaaucccuuc                                                   20


<210>  14285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14285
ggucuaaucu cuacaauccc                                                   20


<210>  14286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14286
ucaggucuaa ucucuacaau                                                   20


<210>  14287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14287
aaggggccuc cucaggucua                                                   20


<210>  14288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14288
cugacuaaau uuuauucuuu                                                   20


<210>  14289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14289
gacuaaauuu uauucuuuau                                                   20


<210>  14290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14290
ccgugugcug acucaucaua                                                   20


<210>  14291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14291
ucauaauaau gaguagcucu                                                   20


<210>  14292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14292
uuauuaugau gagucagcac                                                   20


<210>  14293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14293
cauugugcuu gucuauuugg                                                   20


<210>  14294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14294
uugugcuugu cuauuuggac                                                   20


<210>  14295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14295
uacaaugauu uuuuuuuuuu                                                   20


<210>  14296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14296
aagaaaaaaa aaaaaucauu                                                   20


<210>  14297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14297
gucucaaaga aaaaaaaaaa                                                   20


<210>  14298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14298
guugccuagg cuggagugca                                                   20


<210>  14299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14299
agccuaggca acagagcaag                                                   20


<210>  14300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14300
gcucacugca gccuccaccu                                                   20


<210>  14301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14301
cugcagccuc caccucccag                                                   20


<210>  14302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14302
accucccagg uucaagugau                                                   20


<210>  14303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14303
cagguucaag ugauucuugu                                                   20


<210>  14304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14304
gcuucucaag uagcugagac                                                   20


<210>  14305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14305
aguagcugag acugcaggug                                                   20


<210>  14306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14306
gcuacuugag aagcugaggc                                                   20


<210>  14307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14307
acuaaaaaua caaacauuag                                                   20


<210>  14308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14308
aacuccugac cucaagugau                                                   20


<210>  14309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14309
ugaccucaag ugaucugccu                                                   20


<210>  14310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14310
agugaucugc cuucuucagc                                                   20


<210>  14311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14311
caaagugcug ggauuacagg                                                   20


<210>  14312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14312
caccuguaau cccagcacuu                                                   20


<210>  14313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14313
guggcucaca ccuguaaucc                                                   20


<210>  14314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14314
gacaaacuuu uuuagcugca                                                   20


<210>  14315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14315
agguguuuuc ucagggagaa                                                   20


<210>  14316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14316
gggagaaauu ggaggcagua                                                   20


<210>  14317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14317
cugagaaaac accuggagaa                                                   20


<210>  14318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14318
aauuucuccc ugagaaaaca                                                   20


<210>  14319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14319
cccaguggcu uacugccucc                                                   20


<210>  14320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14320
uugucaggga guccuguggc                                                   20


<210>  14321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14321
cugacaagga gccacaggac                                                   20


<210>  14322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14322
uugccagcca caggacuccc                                                   20


<210>  14323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14323
ccuugccagc cacaggacuc                                                   20


<210>  14324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14324
caacccagcc acaggacuuc                                                   20


<210>  14325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14325
cucccaaccc agccacagga                                                   20


<210>  14326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14326
uccugugccu aacagugucc                                                   20


<210>  14327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14327
ggacacuguu aggcacagga                                                   20


<210>  14328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14328
gcaccucugg acacuguuag                                                   20


<210>  14329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14329
gucggggaga cccuaaccca                                                   20


<210>  14330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14330
ccgacugagc uggucucggc                                                   20


<210>  14331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14331
agcgcugcug gguuaggguc                                                   20


<210>  14332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14332
auauuucugu gugugugucu                                                   20


<210>  14333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14333
cagccuuuag agcugagagc                                                   20


<210>  14334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14334
aaaggcugug agaccccuga                                                   20


<210>  14335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14335
gcucuaaagg cugugagacc                                                   20


<210>  14336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14336
cagcucuaaa ggcugugaga                                                   20


<210>  14337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14337
guucagggcu cucagcucua                                                   20


<210>  14338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14338
uuucccauaa gggauacuuu                                                   20


<210>  14339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14339
ucuuuuaauu cggcccaucc                                                   20


<210>  14340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14340
ugcugcgguu aacuagccca                                                   20


<210>  14341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14341
ugcuauuguu uguggcuuaa                                                   20


<210>  14342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14342
uuccugucaa cccacaaccu                                                   20


<210>  14343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14343
gaagcacugu aacauguuca                                                   20


<210>  14344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14344
caauacagag gucucgugua                                                   20


<210>  14345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14345
guauugggag caggcccccc                                                   20


<210>  14346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14346
uguaaauucc cugggaggcg                                                   20


<210>  14347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14347
cagggaauuu acacgagacc                                                   20


<210>  14348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14348
gagaaacaga cuaugcuaac                                                   20


<210>  14349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14349
gaggcuuauc gccucccagg                                                   20


<210>  14350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14350
uucauggcgu gguuagcaua                                                   20


<210>  14351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14351
gacagagucc ccgacucaua                                                   20


<210>  14352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14352
gucagagcua cgccugggca                                                   20


<210>  14353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14353
uagugcuugc ucagugcaug                                                   20


<210>  14354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14354
gugcaugcug aacaaugauu                                                   20


<210>  14355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14355
gagcauaguu uugaauaaug                                                   20


<210>  14356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14356
gagccaugac uugauuccaa                                                   20


<210>  14357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14357
aaugauggcc auuuaaaucu                                                   20


<210>  14358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14358
uuuggauugu ccuagaggcc                                                   20


<210>  14359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14359
aggacaaucc aaaggagaaa                                                   20


<210>  14360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14360
ugggccucua ggacaaucca                                                   20


<210>  14361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14361
uaagaaauua gggaauacuu                                                   20


<210>  14362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14362
ggacuggaac aucuucgauc                                                   20


<210>  14363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14363
uagggugggg cauuuacugc                                                   20


<210>  14364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14364
uuucuccuua acuuugucau                                                   20


<210>  14365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14365
uuaacuuugu cauuuguuga                                                   20


<210>  14366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14366
gcccacagua uuuggggaca                                                   20


<210>  14367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14367
auucuagaua cacucugccc                                                   20


<210>  14368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14368
accauugcgg agaggacaug                                                   20


<210>  14369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14369
gcaauggugg aggccucaau                                                   20


<210>  14370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14370
ccgcaauggu ggaggccuca                                                   20


<210>  14371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14371
gcauccaugu ccucuccgca                                                   20


<210>  14372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14372
ggggacugcu cagcauccau                                                   20


<210>  14373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14373
ugaguguccc aaauuugggg                                                   20


<210>  14374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14374
agagcaguuu acagacaugu                                                   20


<210>  14375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14375
aacuguuuau acuuugcaag                                                   20


<210>  14376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14376
uaugaagcuu aucauguauu                                                   20


<210>  14377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14377
cccaccauuc ggcggacagc                                                   20


<210>  14378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14378
cugcugaucc agccgcuguc                                                   20


<210>  14379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14379
agaaggacac aauauuucua                                                   20


<210>  14380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14380
uagguaaggu ggaggcauau                                                   20


<210>  14381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14381
accuuaccua agagcacauu                                                   20


<210>  14382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14382
uaugccucca ccuuaccuaa                                                   20


<210>  14383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14383
uccacucaua ugccuccacc                                                   20


<210>  14384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14384
agcauguacu caagauagac                                                   20


<210>  14385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14385
agauagaccu uugaaauaaa                                                   20


<210>  14386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14386
gcuucuagac caggcuauuu                                                   20


<210>  14387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14387
cagcagcccc agugcaguuc                                                   20


<210>  14388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14388
gugacccugc agaugcagcc                                                   20


<210>  14389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14389
caccagccca cacccacugc                                                   20


<210>  14390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14390
gucugugucg gccaugacua                                                   20


<210>  14391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14391
ccauagucau ggccgacaca                                                   20


<210>  14392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14392
agccuacaag acucaccaua                                                   20


<210>  14393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14393
gguuccugcg gguucucugu                                                   20


<210>  14394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14394
guaggucagu ugacaguuuc                                                   20


<210>  14395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14395
uguuguuugg guaacugugg                                                   20


<210>  14396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14396
cuucagcacu ugccaguguu                                                   20


<210>  14397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14397
cugccuuuga aagccagguc                                                   20


<210>  14398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14398
cuggaaagga ccuugcugag                                                   20


<210>  14399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14399
ggaaaggacc uugcugagcu                                                   20


<210>  14400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14400
gcaagguccu uuccagagag                                                   20


<210>  14401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14401
uggcguacuc guucaugauc                                                   20


<210>  14402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14402
uucaugauca uguuugugcc                                                   20


<210>  14403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14403
caggaucucu ucuuuuuuaa                                                   20


<210>  14404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14404
ggaucucuuc uuuuuuaaca                                                   20


<210>  14405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14405
ucuuuuuuaa cagauuaagc                                                   20


<210>  14406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14406
aaacagugag ucagauguua                                                   20


<210>  14407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14407
cuguuuggag auucccggcu                                                   20


<210>  14408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14408
uuccugucga ggaugaacac                                                   20


<210>  14409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14409
acaggaacga guaagccugu                                                   20


<210>  14410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14410
acucugcuga uucuuggcgu                                                   20


<210>  14411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14411
gcugauucuu ggcgugcugc                                                   20


<210>  14412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14412
cccugaggua uuuggugccc                                                   20


<210>  14413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14413
gggugagcag cacgccaaga                                                   20


<210>  14414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14414
gaagcugccu uucaggcuug                                                   20


<210>  14415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14415
ccuucugcag agcagcuugu                                                   20


<210>  14416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14416
uucugcagag cagcuugucc                                                   20


<210>  14417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14417
gcagaaggag agacuuccau                                                   20


<210>  14418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14418
uaccuggaca agcugcucug                                                   20


<210>  14419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14419
aggcccugca ugugaaugac                                                   20


<210>  14420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14420
uccaaauuaa ucgguucuuu                                                   20


<210>  14421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14421
guucugccgc uucucuucca                                                   20


<210>  14422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14422
cgguucugcc gcuucucuuc                                                   20


<210>  14423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14423
aacucucggu ucugccgcuu                                                   20


<210>  14424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14424
ggagcugcgc ugcucguuuc                                                   20


<210>  14425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14425
agaguccaca ccucuaacuc                                                   20


<210>  14426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14426
uuuccaaccc uaggugcuga                                                   20


<210>  14427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14427
agcugucuuc ccucuguaug                                                   20


<210>  14428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14428
guaugucccu gucaccguga                                                   20


<210>  14429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14429
cggugacagg gacauacaga                                                   20


<210>  14430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14430
ucaggugccg uguuaccuaa                                                   20


<210>  14431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14431
ggugccgugu uaccuaagcc                                                   20


<210>  14432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14432
cagagaccac ugcuacccug                                                   20


<210>  14433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14433
gagaccacug cuacccuguu                                                   20


<210>  14434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14434
gagaggcuua gguaacacgg                                                   20


<210>  14435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14435
gguuuuagaa acaggguagc                                                   20


<210>  14436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14436
aucaguauuu acugggugga                                                   20


<210>  14437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14437
gggauagggg cuggguauac                                                   20


<210>  14438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14438
ccauuguaua cccagccccu                                                   20


<210>  14439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14439
acggggcaga agcugcagcu                                                   20


<210>  14440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14440
cucaaggaga uagggacgug                                                   20


<210>  14441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14441
aggagauagg gacguggucg                                                   20


<210>  14442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14442
uugagugagc auauaccacc                                                   20


<210>  14443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14443
uuccaaugca gagaaaccuu                                                   20


<210>  14444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14444
gcauuggaaa gagaaguucc                                                   20


<210>  14445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14445
gguuauuuca cuaacuaugu                                                   20


<210>  14446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14446
uuuuaagcaa uuggauuuuu                                                   20


<210>  14447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14447
gugcuuaaau uauuagcauu                                                   20


<210>  14448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14448
gcuguuuauc aacacgcagc                                                   20


<210>  14449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14449
uaagaaagua uuggggcuga                                                   20


<210>  14450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14450
gccccaauac uuucuuaaga                                                   20


<210>  14451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14451
cagccccaau acuuucuuaa                                                   20


<210>  14452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14452
gcuuuuauuc ugaaaaauaa                                                   20


<210>  14453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14453
ugggauauga cauuuauauu                                                   20


<210>  14454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14454
gcaguguuuu uugugaagga                                                   20


<210>  14455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14455
acaaaacacu cagcaguguu                                                   20


<210>  14456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14456
auaaaaagcu agcuuaaaaa                                                   20


<210>  14457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14457
ugaccaguua uauuucauuu                                                   20


<210>  14458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14458
cuuuuuuuau uauuugaaag                                                   20


<210>  14459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14459
uauuucaucu auaaguauuu                                                   20


<210>  14460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14460
auagaugagg acucuucuuu                                                   20


<210>  14461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14461
ucuauagaga uacugaaaua                                                   20


<210>  14462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14462
ucuuuauuuu uaaaacuuua                                                   20


<210>  14463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14463
caaaguucug ggauuacagg                                                   20


<210>  14464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14464
cagguucaag ugauccgccc                                                   20


<210>  14465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14465
aacucccagg uucaagugau                                                   20


<210>  14466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14466
caaguagcug ggacuacagg                                                   20


<210>  14467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14467
gccucccaag uagcugggac                                                   20


<210>  14468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14468
caucucagcc ucccaaguag                                                   20


<210>  14469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14469
ugugacccuc ccaucucagc                                                   20


<210>  14470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14470
auccugggug auggagcaag                                                   20


<210>  14471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14471
aucacccagg auggagugca                                                   20


<210>  14472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14472
aaaaaacaaa acugcaaaac                                                   20


<210>  14473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14473
uuaucaauuu uucucucuac                                                   20


<210>  14474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14474
cuacucuuuu ggaaucagca                                                   20


<210>  14475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14475
acucuuuugg aaucagcauc                                                   20


<210>  14476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14476
uuuggaauca gcaucuaaau                                                   20


<210>  14477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14477
uugaugaacu gguuccccuc                                                   20


<210>  14478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14478
aucccaguuu uuuucccuua                                                   20


<210>  14479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14479
aagggaaaaa aacugggaug                                                   20


<210>  14480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14480
auaaaugaac ucuaagggaa                                                   20


<210>  14481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14481
acuguguaaa uuaacaccuu                                                   20


<210>  14482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14482
ucucuguauu uccuguaaau                                                   20


<210>  14483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14483
guauuuccug uaaaucaaua                                                   20


<210>  14484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14484
aauuauugau uuacaggaaa                                                   20


<210>  14485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14485
gauauaaaau auacacuaaa                                                   20


<210>  14486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14486
uuuaaaaagu auugaaacua                                                   20


<210>  14487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14487
auuuuuuuua acugaugcuu                                                   20


<210>  14488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14488
aaacuuuuau gaucaagcag                                                   20


<210>  14489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14489
accuugcuaa acgguuuagu                                                   20


<210>  14490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14490
aggccccacc augugcaccu                                                   20


<210>  14491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14491
ugacugaacu ucuccaggcc                                                   20


<210>  14492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14492
gugccggguc agauuccacg                                                   20


<210>  14493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14493
caacucugug ccgggucaga                                                   20


<210>  14494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14494
ugucuucucc caacucugug                                                   20


<210>  14495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14495
ugggacuuag caaagaccac                                                   20


<210>  14496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14496
cccuuucacu ccugggacuu                                                   20


<210>  14497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14497
cagcacacga gugugggugc                                                   20


<210>  14498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14498
ugugcuguga gcacugucuc                                                   20


<210>  14499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14499
gucuacgcac ccacacucgu                                                   20


<210>  14500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14500
uagauuagca agagugcugg                                                   20


<210>  14501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14501
ugcuaaucua ugagaaagcc                                                   20


<210>  14502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14502
guaaccagca cucuugcuaa                                                   20


<210>  14503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14503
aucccugucc uuccaggauu                                                   20


<210>  14504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14504
cauccauacc cuuuuuuccc                                                   20


<210>  14505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14505
aaaguaaaua aaugaugugg                                                   20


<210>  14506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14506
agauaugauu aucucuauaa                                                   20


<210>  14507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14507
auaacauauc uuacuccauc                                                   20


<210>  14508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14508
aucuucuuuu gacuaaaaac                                                   20


<210>  14509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14509
ugguaauuua auuaagaaca                                                   20


<210>  14510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14510
auuuuucaau uuauuccuuu                                                   20


<210>  14511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14511
cucaccuagg caugcaguaa                                                   20


<210>  14512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14512
caccuaggca ugcaguaaaa                                                   20


<210>  14513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14513
ccuaggcaug caguaaaagc                                                   20


<210>  14514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14514
gcccagcuuc uuaaacauac                                                   20


<210>  14515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14515
uuguugauaa uauaugcaua                                                   20


<210>  14516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14516
cuccuuguug auaauauaug                                                   20


<210>  14517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14517
uauggauggu uacuaauugc                                                   20


<210>  14518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14518
aaucuauuac uugcuuaaaa                                                   20


<210>  14519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14519
uacucuaauc uauuacuugc                                                   20


<210>  14520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14520
uucaaaugac auggaguagu                                                   20


<210>  14521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14521
augucauuug aaagagaaug                                                   20


<210>  14522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14522
gaaagaaaga aagauuucag                                                   20


<210>  14523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14523
gaaagaaaua uuucauuauu                                                   20


<210>  14524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14524
acuucuaggc agagaacauu                                                   20


<210>  14525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14525
gccuagaagu ugagccaaaa                                                   20


<210>  14526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14526
uagguaacac uauuuacauu                                                   20


<210>  14527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14527
auaguaugaa agcagugcug                                                   20


<210>  14528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14528
uaaauucugu uagcaacagc                                                   20


<210>  14529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14529
ucugcccccu ccuaaauucu                                                   20


<210>  14530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14530
auguaauaag gaaaucagca                                                   20


<210>  14531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14531
caauguaaua aggaaaucag                                                   20


<210>  14532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14532
ucucaaugua auaaggaaau                                                   20


<210>  14533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14533
uggcuccucu caauguaaua                                                   20


<210>  14534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14534
acguaaucag cuuauacuuu                                                   20


<210>  14535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14535
acacuaccuu uguagcauga                                                   20


<210>  14536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14536
guuccgguga aacuuuaggu                                                   20


<210>  14537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14537
ucugauggua acuucuauac                                                   20


<210>  14538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14538
cuuuuagcuc uucugauggu                                                   20


<210>  14539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14539
ucuacacugu cugauuuuga                                                   20


<210>  14540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14540
uaauguaucu gaaguucaaa                                                   20


<210>  14541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14541
aauuuaaacu guaaacaaac                                                   20


<210>  14542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14542
gcagccuggg gguuggggac                                                   20


<210>  14543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14543
gcagccuggg gguuggggac                                                   20


<210>  14544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14544
cuuccugcug ggcagccugg                                                   20


<210>  14545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14545
ccugcugcuc acuuccugcu                                                   20


<210>  14546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14546
ggugggaaug ccagcucacc                                                   20


<210>  14547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14547
ugucagauca guggcagcau                                                   20


<210>  14548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14548
uaugggaauc uaaugcugcc                                                   20


<210>  14549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14549
caugugcagu ucacaauagg                                                   20


<210>  14550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14550
uuaugagaau cuaaugccug                                                   20


<210>  14551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14551
uaaggagcgc acaaccuaga                                                   20


<210>  14552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14552
gaucaucagg cauuagauuc                                                   20


<210>  14553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14553
ucuugaaacc auccccuggc                                                   20


<210>  14554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14554
caugaaacca gucucuggug                                                   20


<210>  14555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14555
ggugccagaa agguugggua                                                   20


<210>  14556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14556
uucucagugg cacucauaau                                                   20


<210>  14557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14557
guggcacuca uaauaguguu                                                   20


<210>  14558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14558
uaauaguguu uuuugauuuu                                                   20


<210>  14559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14559
ccccuccgug uaugcugggc                                                   20


<210>  14560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14560
ccuccgugua ugcugggcuu                                                   20


<210>  14561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14561
guguaugcug ggcuuuauuu                                                   20


<210>  14562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14562
auuucccaaa acuggugacu                                                   20


<210>  14563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14563
ugcugcuccu cuagugcaag                                                   20


<210>  14564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14564
ucuagugcaa gugcuccauu                                                   20


<210>  14565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14565
agugcaagug cuccauuuau                                                   20


<210>  14566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14566
auuuauuuuu aaggaauuaa                                                   20


<210>  14567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14567
cccuaaauau uucccuauca                                                   20


<210>  14568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14568
gaccagaaca ccuguguuuc                                                   20


<210>  14569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14569
guuucuaggu uuaugaacug                                                   20


<210>  14570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14570
ggucacaaca uuguggucuu                                                   20


<210>  14571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14571
agggcuccgg ucacaacauu                                                   20


<210>  14572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14572
ucagaacgcc uccacccgag                                                   20


<210>  14573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14573
acccgagcuu cugcaaaccc                                                   20


<210>  14574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14574
gguggaggcg uucugaagag                                                   20


<210>  14575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14575
ccgcugcuaa ggaggagucu                                                   20


<210>  14576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14576
uuagcagcgg ugagcugccc                                                   20


<210>  14577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14577
uccuuagcag cggugagcug                                                   20


<210>  14578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14578
cacuacggcu ucggccacca                                                   20


<210>  14579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14579
uacaauuaac uuugcaguaa                                                   20


<210>  14580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14580
auugauuaug ggccugcccu                                                   20


<210>  14581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14581
ccuauuuaua aaauaaagau                                                   20


<210>  14582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14582
cgccuguaau uucagcacuu                                                   20


<210>  14583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14583
ugggcugaag cgauccuucc                                                   20


<210>  14584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14584
aacuccuggg cugaagcgau                                                   20


<210>  14585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14585
cuuggccagg uugucucaaa                                                   20


<210>  14586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14586
acaaaaaaaa aaaaaaaaaa                                                   20


<210>  14587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14587
aaagcagcug ggacuacagg                                                   20


<210>  14588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14588
gccuccaaag cagcugggac                                                   20


<210>  14589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14589
ugggcuuaag caauccuacc                                                   20


<210>  14590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14590
accucuuggg cuuaagcaau                                                   20


<210>  14591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14591
gugcagcugc caucaagauu                                                   20


<210>  14592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14592
gucaccaggc ucagugcagc                                                   20


<210>  14593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14593
aaauaaauuu aaaaauaaaa                                                   20


<210>  14594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14594
uauuuuauuu uuaaauuuau                                                   20


<210>  14595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14595
uuuugccacc caaccugcua                                                   20


<210>  14596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14596
uccugauucu uuucucugcc                                                   20


<210>  14597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14597
ugauucuuuu cucugccuug                                                   20


<210>  14598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14598
gccuuggcug ccuccugugg                                                   20


<210>  14599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14599
uguggcauuu uaggugcuga                                                   20


<210>  14600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14600
gcaccuaaaa ugccacagga                                                   20


<210>  14601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14601
uguuaauuug ccagaaaugg                                                   20


<210>  14602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14602
gacgacuuga agaugccauu                                                   20


<210>  14603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14603
gaucccucug acgacuugaa                                                   20


<210>  14604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14604
cagaucccuc ugacgacuug                                                   20


<210>  14605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14605
agucaggcca ggaaggaacu                                                   20


<210>  14606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14606
gcgucugccu ccacugccca                                                   20


<210>  14607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14607
acugcccagu caccuccucu                                                   20


<210>  14608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14608
ucuccaugcu cuuggggcug                                                   20


<210>  14609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14609
ccaugcucuu ggggcugggc                                                   20


<210>  14610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14610
augcucuugg ggcugggccc                                                   20


<210>  14611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14611
uggggcuggg cccuacccca                                                   20


<210>  14612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14612
agggcagcac ugcauggugg                                                   20


<210>  14613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14613
cugcuccagg gcagcacugc                                                   20


<210>  14614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14614
ugccagacag gacccaccaa                                                   20


<210>  14615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14615
caugccagac aggacccacc                                                   20


<210>  14616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14616
caaaggcagc ucucaugcca                                                   20


<210>  14617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14617
accacugggu cuggugccua                                                   20


<210>  14618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14618
ggccucuccu aagccacugc                                                   20


<210>  14619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14619
ccuaagccac ugcaacgugg                                                   20


<210>  14620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14620
uaagccacug caacgugguc                                                   20


<210>  14621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14621
cagccuccac auuagagaga                                                   20


<210>  14622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14622
acauuagaga gaaucugacu                                                   20


<210>  14623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14623
aauguggagg cugugaguaa                                                   20


<210>  14624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14624
cuaaugugga ggcugugagu                                                   20


<210>  14625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14625
ugugaacaua aauguuugcc                                                   20


<210>  14626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14626
ugguucuggc aaacauuuau                                                   20


<210>  14627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14627
uuauuuguaa ggcacgcauu                                                   20


<210>  14628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14628
gauuauuuag cugacuaaca                                                   20


<210>  14629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14629
aguuuuaaag uugaaucaag                                                   20


<210>  14630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14630
agcugcaaau cacagaaagu                                                   20


<210>  14631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14631
ugcagcccug uccuuucaag                                                   20


<210>  14632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14632
gauuucugaa auaaucaccu                                                   20


<210>  14633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14633
guguauaucu cuucucagau                                                   20


<210>  14634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14634
ucucagauga gugauuauau                                                   20


<210>  14635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14635
gaugagugau uauaugugug                                                   20


<210>  14636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14636
ucugagaaga gauauacaca                                                   20


<210>  14637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14637
gucccuuuac aaaaaaaguc                                                   20


<210>  14638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14638
uuugcaacau ucagcucugc                                                   20


<210>  14639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14639
gcccugugac aggaaugcag                                                   20


<210>  14640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14640
ugucuuuaca acugcauucc                                                   20


<210>  14641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14641
caaaauauaa caacacauuc                                                   20


<210>  14642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14642
guaaauuuua uuuaguauua                                                   20


<210>  14643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14643
cuauguugac caggcuggaa                                                   20


<210>  14644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14644
accaaaacaa aacaaaacaa                                                   20


<210>  14645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14645
gcugcugcuc agggggcuga                                                   20


<210>  14646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14646
gggggcugag gcaagaggau                                                   20


<210>  14647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14647
gcccccugag cagcagcuga                                                   20


<210>  14648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14648
ugccucagcc cccugagcag                                                   20


<210>  14649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14649
aacaauccuc uugccucagc                                                   20


<210>  14650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14650
ugggcucaaa caauccucuu                                                   20


<210>  14651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14651
aacuccuggg cucaaacaau                                                   20


<210>  14652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14652
cugugaccuc aaacuccugg                                                   20


<210>  14653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14653
agccuaggca acagaaugag                                                   20


<210>  14654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14654
uucuguugcc uaggcuggag                                                   20


<210>  14655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14655
aaucaugaca caaaaaagga                                                   20


<210>  14656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14656
auuaaauacu caaaucauga                                                   20


<210>  14657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14657
caauuaaaua cucaaaucau                                                   20


<210>  14658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14658
uaagaaaugu uuacuuaauu                                                   20


<210>  14659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14659
uacuaugaug acgcaaauau                                                   20


<210>  14660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14660
aacuugauua aguaucucau                                                   20


<210>  14661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14661
uaauucaaga auauagacau                                                   20


<210>  14662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14662
ccuaauucaa gaauauagac                                                   20


<210>  14663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14663
ccgccacugg aaaaagcgac                                                   20


<210>  14664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14664
gaugaguuua uccucuucug                                                   20


<210>  14665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14665
ucugagcaau gugaaucagu                                                   20


<210>  14666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14666
ucuggcuggg acaugggaua                                                   20


<210>  14667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14667
uuuaagccuu uuugguauuu                                                   20


<210>  14668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14668
augggggaaa aauaccaaaa                                                   20


<210>  14669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14669
caauggggga aaaauaccaa                                                   20


<210>  14670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14670
ucuguuauag cuggaaaauc                                                   20


<210>  14671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14671
accuucaucu gucuuauaau                                                   20


<210>  14672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14672
aggacacccc cacuacuuuc                                                   20


<210>  14673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14673
cuucuggugg cagccuagcu                                                   20


<210>  14674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14674
ucugguggca gccuagcucu                                                   20


<210>  14675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14675
ugugccuuug aggaaauuac                                                   20


<210>  14676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14676
aaggcacaag agcuaggcug                                                   20


<210>  14677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14677
guggaacaua uuugcaaacc                                                   20


<210>  14678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14678
aucuuccaaa ucagugguuu                                                   20


<210>  14679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14679
agguaaagaa cuuauuuugu                                                   20


<210>  14680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14680
uuuuuucacu cuuaaucuca                                                   20


<210>  14681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14681
uaaucucaca ucauuguaag                                                   20


<210>  14682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14682
caucauugua aguuuaugga                                                   20


<210>  14683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14683
ucaaagaaaa agucagaagu                                                   20


<210>  14684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14684
caugugaugu agccacaaag                                                   20


<210>  14685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14685
uuaaaucuuu guggcuacau                                                   20


<210>  14686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14686
uuaauguaau ucugaagaug                                                   20


<210>  14687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14687
aauaccuaaa agucacuuuc                                                   20


<210>  14688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14688
aaugacacac cagaauuuau                                                   20


<210>  14689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14689
aacuauacca caaaacauuu                                                   20


<210>  14690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14690
acauucuuug uguuuaauac                                                   20


<210>  14691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14691
acaguauuaa acacaaagaa                                                   20


<210>  14692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14692
aauauaguuu aucaucauau                                                   20


<210>  14693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14693
uaagaauauu uaauuuacuc                                                   20


<210>  14694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14694
aaaaugaaac ucauaagaau                                                   20


<210>  14695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14695
uaggagaaga agaagccuug                                                   20


<210>  14696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14696
uaagagcacu uugccuagua                                                   20


<210>  14697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14697
aaggcuucuu cuucuccuaa                                                   20


<210>  14698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14698
gaaucgagau cggaugucag                                                   20


<210>  14699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14699
auucagaguc auccuccaag                                                   20


<210>  14700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14700
gccuuaacag guaguucuca                                                   20


<210>  14701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14701
cuaguuagcc gcuggugugg                                                   20


<210>  14702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14702
ucccccugca ccugguggac                                                   20


<210>  14703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14703
acugcugccc ccagucgugc                                                   20


<210>  14704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14704
gaagcuugug ugucuguggu                                                   20


<210>  14705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14705
agccauaaac cuaauuuuaa                                                   20


<210>  14706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14706
caaagcccua ugcucaagcc                                                   20


<210>  14707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14707
ugaguuggau ggguuaugcu                                                   20


<210>  14708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14708
ugagauguuu cgaccugcca                                                   20


<210>  14709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14709
aaaaagaaaa aagauaacua                                                   20


<210>  14710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14710
aucucaaaaa agaaaaaaga                                                   20


<210>  14711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14711
cacugucacc cagugcagau                                                   20


<210>  14712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14712
agugacacug gguaucugca                                                   20


<210>  14713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14713
uggugcacug cagccuccgc                                                   20


<210>  14714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14714
gccuucuggg uuccagcgau                                                   20


<210>  14715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14715
ugccucagcc ucccaaguag                                                   20


<210>  14716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14716
gccucccaag uagcugggac                                                   20


<210>  14717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14717
caaguagcug ggacuacagg                                                   20


<210>  14718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14718
acaaaaaaau acaaaaauua                                                   20


<210>  14719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14719
ugaccucaag ugaucugccu                                                   20


<210>  14720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14720
agugaucugc cugccucagc                                                   20


<210>  14721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14721
gccucccaca gugccgggau                                                   20


<210>  14722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14722
cacagugccg ggauuacagg                                                   20


<210>  14723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14723
uguaaucccg gcacuguggg                                                   20


<210>  14724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14724
cuccuguaau cccggcacug                                                   20


<210>  14725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14725
guguacuuua uaaaagauga                                                   20


<210>  14726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14726
ucuuuuauaa aguacacaga                                                   20


<210>  14727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14727
uauaauccag uuauuaguac                                                   20


<210>  14728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14728
aaauauuuaa gucuuacuuu                                                   20


<210>  14729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14729
cuaaauauuu aagucuuacu                                                   20


<210>  14730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14730
caugcuuacc gacccaacug                                                   20


<210>  14731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14731
uggggcaguu gggucgguaa                                                   20


<210>  14732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14732
uggaagauaa accuguaaca                                                   20


<210>  14733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14733
aguccuauuc uccuggaaga                                                   20


<210>  14734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14734
acuccagucc uauucuccug                                                   20


<210>  14735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14735
ggggugggcu ugccuucuuc                                                   20


<210>  14736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14736
cugggguggg cuugccuucu                                                   20


<210>  14737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14737
ucucucuggg gugggcuugc                                                   20


<210>  14738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14738
aagcaagcag uggucagaaa                                                   20


<210>  14739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14739
agcuaaggcu uggaguaguc                                                   20


<210>  14740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14740
aagccuuagc uggagcaaua                                                   20


<210>  14741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14741
aaugcuguuu cacugcaaaa                                                   20


<210>  14742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14742
cacuacagua cccaccuuau                                                   20


<210>  14743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14743
cacugccucc cacuacagua                                                   20


<210>  14744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14744
cacacugccu cccacuacag                                                   20


<210>  14745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14745
cgccauuuga caaaugagug                                                   20


<210>  14746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14746
ccauuugaca aaugaguguu                                                   20


<210>  14747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14747
uuugucaaau ggcgagagaa                                                   20


<210>  14748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14748
gucuucagcc ucagugaagg                                                   20


<210>  14749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14749
gugaaggaug agaucagugg                                                   20


<210>  14750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14750
uccuucacug aggcugaaga                                                   20


<210>  14751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14751
acugaucuca uccuucacug                                                   20


<210>  14752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14752
ccacugaucu cauccuucac                                                   20


<210>  14753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14753
agggucagca ggucaugaca                                                   20


<210>  14754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14754
guggaucugg ccagcuguga                                                   20


<210>  14755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14755
gccacugaug gggaugagga                                                   20


<210>  14756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14756
uccccaucag uggcagagcu                                                   20


<210>  14757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14757
ucauccccau caguggcaga                                                   20


<210>  14758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14758
agauauccuc cucaucccca                                                   20


<210>  14759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14759
agccagguca gcgccguccc                                                   20


<210>  14760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14760
ucgcccauca gcgacagcuc                                                   20


<210>  14761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14761
cagaccacca ccgaagggcc                                                   20


<210>  14762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14762
gcccacuuac aauuucagaa                                                   20


<210>  14763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14763
aauaaaaaau aaaaaaaaag                                                   20


<210>  14764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14764
gucucaaaua aaaaauaaaa                                                   20


<210>  14765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14765
cuccauagug caguggaggc                                                   20


<210>  14766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14766
auagugcagu ggaggccggg                                                   20


<210>  14767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14767
acugcacuau ggagugagac                                                   20


<210>  14768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14768
ugccuguaau cccagcacuu                                                   20


<210>  14769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14769
caaagugcug ggauuacagg                                                   20


<210>  14770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14770
gucucccaaa gugcugggau                                                   20


<210>  14771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14771
agugauccgc cugccucagu                                                   20


<210>  14772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14772
ugaccucaag ugauccgccu                                                   20


<210>  14773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14773
aacuccugac cucaagugau                                                   20


<210>  14774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14774
acuaaaaaua caaaaauuag                                                   20


<210>  14775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14775
cuaacagcug ggacuacaga                                                   20


<210>  14776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14776
gccucccuaa cagcugggac                                                   20


<210>  14777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14777
ugccucagcc ucccuaacag                                                   20


<210>  14778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14778
agcaauucuc cugccucagc                                                   20


<210>  14779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14779
caggcucaag caauucuccu                                                   20


<210>  14780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14780
gccucccagg cucaagcaau                                                   20


<210>  14781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14781
uugcaaccuc ugccucccag                                                   20


<210>  14782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14782
gcucauugca accucugccu                                                   20


<210>  14783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14783
agcccgggca acagagcaag                                                   20


<210>  14784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14784
guugcccggg cuggagugca                                                   20


<210>  14785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14785
auuucaaaaa aaauaaaaaa                                                   20


<210>  14786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14786
uucucagccc acugcaacuu                                                   20


<210>  14787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14787
gcccacugca acuucugccu                                                   20


<210>  14788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14788
caggcucgag cgauucuccc                                                   20


<210>  14789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14789
agcgauucuc ccgccucagc                                                   20


<210>  14790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14790
agccugggag gcagaaguug                                                   20


<210>  14791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14791
cgccucagcc uccugaguag                                                   20


<210>  14792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14792
gccuccugag uaggugggau                                                   20


<210>  14793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14793
ugaguaggug ggauuacagg                                                   20


<210>  14794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14794
ggaggcugag gcgggagaau                                                   20


<210>  14795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14795
gcuaauguuu guauuuucag                                                   20


<210>  14796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14796
acugaaaaua caaacauuag                                                   20


<210>  14797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14797
aacuccugac cuuagaugau                                                   20


<210>  14798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14798
ugaccuuaga ugauccaccc                                                   20


<210>  14799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14799
uaaaguauug ggauuauagu                                                   20


<210>  14800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14800
caacuauaau cccaauacuu                                                   20


<210>  14801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14801
aaagauggca gguggcaggg                                                   20


<210>  14802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14802
agggaagaac ucaaaagaug                                                   20


<210>  14803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14803
ugcuuguucu cuuguuaucu                                                   20


<210>  14804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14804
uguuaucuaa uaccccuauu                                                   20


<210>  14805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14805
auuaaugauc uaagcugcgc                                                   20


<210>  14806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14806
ccauuaauga ucuaagcugc                                                   20


<210>  14807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14807
ucugauaccu ucacugaagg                                                   20


<210>  14808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14808
guguucaaca caaaagacac                                                   20


<210>  14809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14809
gcuaaaauug agugcauuuu                                                   20


<210>  14810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14810
auuuuagcag aguucauaua                                                   20


<210>  14811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14811
uuaaggauuu uuaaaaauaa                                                   20


<210>  14812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14812
ucucuaaguu aguggacaaa                                                   20


<210>  14813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14813
aaguuagugg acaaaaaacc                                                   20


<210>  14814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14814
uggauagucu aauaauguuu                                                   20


<210>  14815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14815
acauggacuu guagcaaaca                                                   20


<210>  14816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14816
auuuuauuuu caguuuuaaa                                                   20


<210>  14817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14817
guaaccuuuu gaucauguaa                                                   20


<210>  14818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14818
guucccauug aacucuauuc                                                   20


<210>  14819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14819
auuccuccuu ucccgccaag                                                   20


<210>  14820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14820
uuucccgcca agucccuggc                                                   20


<210>  14821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14821
uauacuuuag gagucacaca                                                   20


<210>  14822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14822
uaaaguauau gagaacccaa                                                   20


<210>  14823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14823
ugcauguugu agccuauguu                                                   20


<210>  14824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14824
guccauggac acuuguauug                                                   20


<210>  14825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14825
uggagacucu gcuuuccauu                                                   20


<210>  14826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14826
aggagcuauc uguacaccca                                                   20


<210>  14827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14827
gcuuuccauu uuuuuggcua                                                   20


<210>  14828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14828
auuucugggu auuuagccaa                                                   20


<210>  14829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14829
augauaugaa uguuuuaaau                                                   20


<210>  14830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14830
uaaauugcaa agacuaaauc                                                   20


<210>  14831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14831
uauuuccaac uugcuguaaa                                                   20


<210>  14832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14832
aaaaaaauuc caauguggac                                                   20


<210>  14833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14833
aaaaacucca aaaaaauucc                                                   20


<210>  14834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14834
auuagcucua aaaacuccaa                                                   20


<210>  14835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14835
uucccacuac auuaugaaaa                                                   20


<210>  14836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14836
uagcaguuuc caugcgugca                                                   20


<210>  14837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14837
ucugucauuu auuucaaggc                                                   20


<210>  14838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14838
uuccucauug cacuuccaug                                                   20


<210>  14839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14839
uugcacuucc auguuggagg                                                   20


<210>  14840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14840
aacauggaag ugcaaugagg                                                   20


<210>  14841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14841
uggugaucac acuucaaaau                                                   20


<210>  14842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14842
cagccccccu ugaaccguuu                                                   20


<210>  14843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14843
ucuucauccu ggggcugucc                                                   20


<210>  14844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14844
gaggccuuca ggaacucuuc                                                   20


<210>  14845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14845
gaggcuucau caggaagaau                                                   20


<210>  14846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14846
uccaugggua uguggacuac                                                   20


<210>  14847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14847
gaaaacagua ucaaaggacu                                                   20


<210>  14848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14848
auuggucauu uucaucagcu                                                   20


<210>  14849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14849
aaaguauaag auuuagauca                                                   20


<210>  14850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14850
guuuuuaaag cccuucaaca                                                   20


<210>  14851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14851
uguuuuucaa uaaaugugcc                                                   20


<210>  14852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14852
acacaaauuu aucaacacug                                                   20


<210>  14853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14853
caacacaaau uuaucaacac                                                   20


<210>  14854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14854
ccuuguuuuc uugaucaccc                                                   20


<210>  14855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14855
agccuauguc ccucaccuug                                                   20


<210>  14856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14856
gaaacaccaa gucgucucaa                                                   20


<210>  14857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14857
cacaagcuca gaaacaccaa                                                   20


<210>  14858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14858
ucccaggccu guuguuuucu                                                   20


<210>  14859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14859
aggcuguggg uaguaccugg                                                   20


<210>  14860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14860
ggcaauucuc aaggcugugg                                                   20


<210>  14861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14861
uuugagagug ugccccagac                                                   20


<210>  14862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14862
aaggaggcag aacucaggca                                                   20


<210>  14863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14863
caaaggaggc agaacucagg                                                   20


<210>  14864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14864
cuucauauua ucuuuuuaca                                                   20


<210>  14865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14865
ucauauuauc uuuuuacaug                                                   20


<210>  14866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14866
aggacaagga auagcguuuc                                                   20


<210>  14867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14867
cuaucuacca ggcccacuuc                                                   20


<210>  14868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14868
uagauuuggg cuuccccagg                                                   20


<210>  14869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14869
cugcaugcug cauuuauccc                                                   20


<210>  14870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14870
gacuugucug uuucugcuug                                                   20


<210>  14871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14871
gugaggucag gugugcauau                                                   20


<210>  14872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14872
cagagaccau ggccaagcag                                                   20


<210>  14873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14873
uuauccccag caccuggcuu                                                   20


<210>  14874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14874
ggaacuaucu guugaaugaa                                                   20


<210>  14875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14875
acaauacauu caugcauuag                                                   20


<210>  14876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14876
uacucaacaa uacauucaug                                                   20


<210>  14877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14877
uuucuagccu ugccgcauca                                                   20


<210>  14878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14878
gcaccucuug uccauugugu                                                   20


<210>  14879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14879
uguccauugu guccgccuuu                                                   20


<210>  14880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14880
ccauuuuuuc ccccuguuag                                                   20


<210>  14881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14881
gaaaccuagu uauuuccuuc                                                   20


<210>  14882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14882
gcugcacgca aggcaaaaac                                                   20


<210>  14883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14883
gauucuacuu ccucugcugc                                                   20


<210>  14884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14884
uccucagauu cuacuuccuc                                                   20


<210>  14885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14885
gcuagugaaa accaaacuca                                                   20


<210>  14886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14886
ccucggcuag ugaaaaccaa                                                   20


<210>  14887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14887
cuccccucgg cuagugaaaa                                                   20


<210>  14888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14888
caucauuucc ucccuccccu                                                   20


<210>  14889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14889
aacaacagau uguuuucaaa                                                   20


<210>  14890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14890
caucccuguc cggaaccagc                                                   20


<210>  14891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14891
gcuguguggg agcagcugug                                                   20


<210>  14892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14892
cacacagcug agggccaggg                                                   20


<210>  14893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14893
acccggaauc uuucuucagc                                                   20


<210>  14894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14894
auaaaguucc ucuugacacc                                                   20


<210>  14895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14895
ugacaccacg gaauacccug                                                   20


<210>  14896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14896
gauuuaauca uuauuguaaa                                                   20


<210>  14897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14897
aaaacuaaaa uagucaauac                                                   20


<210>  14898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14898
aaacacuuac ugcucuaaaa                                                   20


<210>  14899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14899
ucagaaaaca caugaauagu                                                   20


<210>  14900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14900
auggguuuca ucuaaaggga                                                   20


<210>  14901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14901
ucuauggguu ucaucuaaag                                                   20


<210>  14902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14902
gcacguaaga gccaacauau                                                   20


<210>  14903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14903
uacgugcuga gguuucuacu                                                   20


<210>  14904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14904
gcgccacugc gaccaggcac                                                   20


<210>  14905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14905
gccaggccag gcauucacac                                                   20


<210>  14906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14906
gggugagugg gaaccaggac                                                   20


<210>  14907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14907
cccugagugu gaaugccugg                                                   20


<210>  14908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14908
gccaguccug guucccacuc                                                   20


<210>  14909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14909
aucgcgccca ugcuuacuau                                                   20


<210>  14910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14910
auaguaagca ugggcgcgau                                                   20


<210>  14911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14911
uucucucuuu uucuuugggu                                                   20


<210>  14912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14912
cuuuuucuuu gggugagagg                                                   20


<210>  14913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14913
uuuucuuugg gugagagggu                                                   20


<210>  14914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14914
cccaaagaaa aagagagaac                                                   20


<210>  14915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14915
cacccaaaga aaaagagaga                                                   20


<210>  14916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14916
uauaaauuca aaaacacaag                                                   20


<210>  14917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14917
auaccacaga cuuucuggau                                                   20


<210>  14918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14918
aauucuuaaa uccugaaacu                                                   20


<210>  14919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14919
ucacaccucu uuuucucuuu                                                   20


<210>  14920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14920
uuuucucuuu ccugagaauu                                                   20


<210>  14921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14921
uuccugagaa uuaagcuuuu                                                   20


<210>  14922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14922
ggaaagagaa aaagaggugu                                                   20


<210>  14923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14923
aaacaaaagc uuaauucuca                                                   20


<210>  14924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14924
gccauggaac aauucccuac                                                   20


<210>  14925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14925
acagaggaac aguaugucuc                                                   20


<210>  14926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14926
guggagauaa auugcucagc                                                   20


<210>  14927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14927
gacaucuuga acuacaucga                                                   20


<210>  14928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14928
augaucgaug uaguucaaga                                                   20


<210>  14929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14929
aaccuguggg ucuccaugau                                                   20


<210>  14930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14930
ucgaaccugu gggucuccau                                                   20


<210>  14931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14931
gugggacccu caucugcucc                                                   20


<210>  14932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14932
ucugcuccau ccucagcagg                                                   20


<210>  14933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14933
auccucagca ggucccgcuu                                                   20


<210>  14934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14934
gcaggucccg cuuccacgug                                                   20


<210>  14935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14935
cacguggaag cgggaccugc                                                   20


<210>  14936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14936
cagguaacgg ccaguuuuuc                                                   20


<210>  14937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14937
uccuucagug uuuuccgcag                                                   20


<210>  14938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14938
cagcuguaca agcuaacuug                                                   20


<210>  14939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14939
cccucacagc uguacaagcu                                                   20


<210>  14940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14940
aauuuuaauu guagcaauga                                                   20


<210>  14941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14941
aaagcuguaa ccaguaauac                                                   20


<210>  14942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14942
cagcuuuaga aagaaaacgu                                                   20


<210>  14943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14943
gcuuuagaaa gaaaacguug                                                   20


<210>  14944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14944
gaauauuugu uugaaauaga                                                   20


<210>  14945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14945
uccuaaagga uauauuuaga                                                   20


<210>  14946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14946
caccuguaau cugaccacuu                                                   20


<210>  14947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14947
caaagugguc agauuacagg                                                   20


<210>  14948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14948
agcaauccuu ccaccuuggc                                                   20


<210>  14949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14949
ugggcucaag caauccuucc                                                   20


<210>  14950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14950
gcuacucggg aagcugaggu                                                   20


<210>  14951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14951
ggaagcugag guggaggggg                                                   20


<210>  14952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14952
gcuucccgag uagcugagac                                                   20


<210>  14953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14953
accucagcuu cccgaguagc                                                   20


<210>  14954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14954
agcaaucccc ccuccaccuc                                                   20


<210>  14955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14955
ggggcucaag caaucccccc                                                   20


<210>  14956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14956
agccugggca acagagugag                                                   20


<210>  14957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14957
guugcccagg cuagagggca                                                   20


<210>  14958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14958
cucuguugcc caggcuagag                                                   20


<210>  14959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14959
aaaauaauag uaauaauaau                                                   20


<210>  14960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14960
uaccauacua ugggccuagc                                                   20


<210>  14961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14961
cuuuaacucu uaccauacua                                                   20


<210>  14962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14962
accucuguuu cuguauaaag                                                   20


<210>  14963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14963
guuucuguau aaaguggaau                                                   20


<210>  14964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14964
auucuuuaag ugauagcaug                                                   20


<210>  14965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14965
uaagucacaa cuggccaguc                                                   20


<210>  14966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14966
uguugacugg ccaguuguga                                                   20


<210>  14967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14967
cccuuuuaaa augucaugcc                                                   20


<210>  14968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14968
cuaguuucca gguuuucagu                                                   20


<210>  14969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14969
aguuuccagg uuuucaguca                                                   20


<210>  14970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14970
aaaaagacac aacugacuga                                                   20


<210>  14971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14971
uagcaugcuu ccuucugcuc                                                   20


<210>  14972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14972
aucuuguggc uagcuggggg                                                   20


<210>  14973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14973
ccugcagccc caagcaccca                                                   20


<210>  14974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14974
cgugcugugg aguacauagu                                                   20


<210>  14975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14975
ugcuguggag uacauaguga                                                   20


<210>  14976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14976
acagcacgag agaacagaac                                                   20


<210>  14977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14977
gacccagggg uaggaacaag                                                   20


<210>  14978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14978
guaacugauc aauguuugug                                                   20


<210>  14979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14979
aacagcaacu ucacaaacau                                                   20


<210>  14980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14980
caaacagcaa cuucacaaac                                                   20


<210>  14981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14981
guaaauacaa gcuuaaaagu                                                   20


<210>  14982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14982
agaacauuga uuaagaauac                                                   20


<210>  14983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14983
caagaacauu gauuaagaau                                                   20


<210>  14984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14984
ucaacacaca auguucuggg                                                   20


<210>  14985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14985
aaccgucaag acgcggguac                                                   20


<210>  14986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14986
guacccgcgu cuugacgguu                                                   20


<210>  14987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14987
ugccuuggac cuuguguucc                                                   20


<210>  14988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14988
ugacacaguu cuggaacaca                                                   20


<210>  14989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14989
gcagcagcag cuacagugag                                                   20


<210>  14990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14990
cuguagcugc ugcugcagag                                                   20


<210>  14991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14991
gaggaacagu uccuauuggc                                                   20


<210>  14992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14992
gagucagcac aucgaugauc                                                   20


<210>  14993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14993
ccagccaaua ggaacuguuc                                                   20


<210>  14994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14994
guccucacca gccaauagga                                                   20


<210>  14995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14995
gcaaggguuu ccagaagcuc                                                   20


<210>  14996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14996
cuuaccugaa gucaaucucu                                                   20


<210>  14997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14997
auugaaaguu cugggaucac                                                   20


<210>  14998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14998
gauuucugau ggacagggua                                                   20


<210>  14999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  14999
ucccaguggc uuuuugcuga                                                   20


<210>  15000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15000
caguggcuuu uugcugaacu                                                   20


<210>  15001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15001
aaauaaauaa uaaaauaaaa                                                   20


<210>  15002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15002
gucgcccagg cuugaaugca                                                   20


<210>  15003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15003
cugaagcuuu gaacucuagg                                                   20


<210>  15004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15004
aggacucaag ugguccuccu                                                   20


<210>  15005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15005
agugguccuc cugccucagc                                                   20


<210>  15006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15006
ugccucagcc ucccgauuag                                                   20


<210>  15007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15007
gccucccgau uagcuaggag                                                   20


<210>  15008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15008
cgauuagcua ggagaauagg                                                   20


<210>  15009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15009
uagcuaaucg ggaggcugag                                                   20


<210>  15010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15010
aacuccuggg cuugauugau                                                   20


<210>  15011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15011
ugggcuugau ugauccucca                                                   20


<210>  15012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15012
aucuuggccu cccaaagugc                                                   20


<210>  15013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15013
caaagugcug ggauuacagg                                                   20


<210>  15014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15014
ugccuguaau cccagcacuu                                                   20


<210>  15015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15015
ucuacuuaua uuuuaaaauu                                                   20


<210>  15016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15016
ucauuuaagu auucuggaua                                                   20


<210>  15017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15017
uuuauuccca cuauccagaa                                                   20


<210>  15018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15018
ucauuauacu gaaccuaggu                                                   20


<210>  15019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15019
cguuuuuuaa uugcaacaaa                                                   20


<210>  15020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15020
cugcaaccac agcucacguu                                                   20


<210>  15021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15021
guugccaggc ugaagugcaa                                                   20


<210>  15022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15022
cucuguugcc aggcugaagu                                                   20


<210>  15023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15023
aaaaaaaaaa aauaacauga                                                   20


<210>  15024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15024
uguuauuuuu uuuuuuuuga                                                   20


<210>  15025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15025
uagaaaauga aagugccaac                                                   20


<210>  15026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15026
agccaaaacu acucuuagaa                                                   20


<210>  15027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15027
auaaaaggug gcuuggaaaa                                                   20


<210>  15028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15028
gcuccaccca cagauaggga                                                   20


<210>  15029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15029
acccacagau agggacgcug                                                   20


<210>  15030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15030
gcgucccuau cugugggugg                                                   20


<210>  15031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15031
ugcacgcuca gcgucccuau                                                   20


<210>  15032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15032
auaaccugcu aucuugcugc                                                   20


<210>  15033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15033
ccccuucugu ggcuugagcc                                                   20


<210>  15034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15034
agccacagaa ggggugagcu                                                   20


<210>  15035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15035
guaagugccc uauaaaauug                                                   20


<210>  15036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15036
guaaacuguu uuucuuuuuc                                                   20


<210>  15037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15037
auaagacagu acucaguaaa                                                   20


<210>  15038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15038
caauuccaga cucaauaaga                                                   20


<210>  15039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15039
cacaauucca gacucaauaa                                                   20


<210>  15040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15040
auuuauuuaa agccauuggc                                                   20


<210>  15041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15041
aaacaacaaa aaaggccaau                                                   20


<210>  15042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15042
uccaggugcc cuggaaggac                                                   20


<210>  15043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15043
ggagcaagcu ggcgguaagu                                                   20


<210>  15044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15044
agagcaggcu cauccaggug                                                   20


<210>  15045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15045
guaaacacuu accgccagcu                                                   20


<210>  15046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15046
uuuguuaggc uggugagcuu                                                   20


<210>  15047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15047
ccagccuaac aaaagagcac                                                   20


<210>  15048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15048
aaaaagcuca ccagccuaac                                                   20


<210>  15049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15049
guguaaguuu ucugcuuuug                                                   20


<210>  15050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15050
ucauuauaca gggguaagcg                                                   20


<210>  15051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15051
caaaaauaaa ccgcuuaccc                                                   20


<210>  15052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15052
cuuucaccuu cuugaaggua                                                   20


<210>  15053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15053
aaaugcauuc gucauguuuu                                                   20


<210>  15054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15054
acauuacuag acuuaaaucc                                                   20


<210>  15055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15055
cuagcuuucc aaaauaucuu                                                   20


<210>  15056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15056
cuaaagcuuu uaaaacugca                                                   20


<210>  15057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15057
aaagcuuuua aaacugcaag                                                   20


<210>  15058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15058
uucuugcagu uuuaaaagcu                                                   20


<210>  15059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15059
auaauguugu cauccauuug                                                   20


<210>  15060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15060
aagcaaaugg augacaacau                                                   20


<210>  15061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15061
uuuccuuuuu ugguugaagu                                                   20


<210>  15062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15062
uaucuuuuag uacuucaacc                                                   20


<210>  15063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15063
uuccauucuc guaucuuuua                                                   20


<210>  15064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15064
cuuuccauuc ucguaucuuu                                                   20


<210>  15065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15065
acauccuuug aauucuuccc                                                   20


<210>  15066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15066
gauucaggaa uacugcucua                                                   20


<210>  15067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15067
uuucagccau ucuauucuua                                                   20


<210>  15068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15068
auaguccaaa auuuuuacaa                                                   20


<210>  15069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15069
agguggcagc agaauugaag                                                   20


<210>  15070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15070
augaguuucu uguucaaaau                                                   20


<210>  15071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15071
uagaguauau agcaaaauau                                                   20


<210>  15072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15072
gaaaaagaaa acuauacaca                                                   20


<210>  15073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15073
acuuccagga auucucagaa                                                   20


<210>  15074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15074
aaaaaaaaau aaaaaaaaaa                                                   20


<210>  15075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15075
gucucaaaaa aaaaauaaaa                                                   20


<210>  15076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15076
auuguccagg ugcuaucucg                                                   20


<210>  15077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15077
gcucacugca accucugucu                                                   20


<210>  15078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15078
cugcaaccuc ugucucccug                                                   20


<210>  15079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15079
gucucccugg uucaagcgau                                                   20


<210>  15080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15080
cugguucaag cgauucuccu                                                   20


<210>  15081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15081
ugccucagcc ucccgaguag                                                   20


<210>  15082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15082
gccucccgag uagcugggau                                                   20


<210>  15083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15083
cgaguagcug ggauuacagg                                                   20


<210>  15084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15084
ggaggcugag gcaggagaau                                                   20


<210>  15085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15085
acuaaaaaua caaaaauuaa                                                   20


<210>  15086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15086
aacuucugac cccgugaucc                                                   20


<210>  15087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15087
caaagugcug ggauuacagg                                                   20


<210>  15088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15088
cgccuguaau cccagcacuu                                                   20


<210>  15089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15089
auaaagcuau uagaagauuu                                                   20


<210>  15090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15090
cuuugagugu auaguaaacu                                                   20


<210>  15091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15091
aagugaguac auuucaagaa                                                   20


<210>  15092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15092
aauuuuauca cauuucuguc                                                   20


<210>  15093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15093
gguuccugcc ccaacuccua                                                   20


<210>  15094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15094
uaggcagcca cucaucuauu                                                   20


<210>  15095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15095
ucuauuuucu gucccuuaag                                                   20


<210>  15096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15096
ugccuguaau cccagcacuu                                                   20


<210>  15097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15097
caaagugcug ggauuacagg                                                   20


<210>  15098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15098
gccucccaaa gugcugggau                                                   20


<210>  15099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15099
agugauccac caaccucggc                                                   20


<210>  15100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15100
ugaccucaag ugauccacca                                                   20


<210>  15101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15101
aacuccugac cucaagugau                                                   20


<210>  15102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15102
acuaaaaaua caaaaauuag                                                   20


<210>  15103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15103
ggaggcugag gcaggagaau                                                   20


<210>  15104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15104
cgaguagcug ggauuacagg                                                   20


<210>  15105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15105
gccucccgag uagcugggau                                                   20


<210>  15106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15106
ugccucagcc ucccgaguag                                                   20


<210>  15107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15107
cagguucaag ugauucuccu                                                   20


<210>  15108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15108
gccucccagg uucaagugau                                                   20


<210>  15109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15109
cugcaaccuc cgccucccag                                                   20


<210>  15110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15110
gcucacugca accuccgccu                                                   20


<210>  15111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15111
guugcccagg uuggaaggca                                                   20


<210>  15112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15112
cuguugccca gguuggaagg                                                   20


<210>  15113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15113
cucuguugcc cagguuggaa                                                   20


<210>  15114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15114
aaacaaacaa agauuuguau                                                   20


<210>  15115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15115
caauuaagua aaagaagcca                                                   20


<210>  15116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15116
auaauaucca ucugauggau                                                   20


<210>  15117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15117
ugaguagauc accuagaagu                                                   20


<210>  15118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15118
agagaaauga agacaugucu                                                   20


<210>  15119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15119
ucaaaaacau accauuguuc                                                   20


<210>  15120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15120
cuuccucccu cccuucccua                                                   20


<210>  15121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15121
cucccuuccc uacuucccuc                                                   20


<210>  15122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15122
cuucccuacu ucccucuccc                                                   20


<210>  15123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15123
cccuuucccu uucccuuccc                                                   20


<210>  15124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15124
cuuucccuuu cccuuccccu                                                   20


<210>  15125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15125
gacuucacca uguaaccaaa                                                   20


<210>  15126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15126
ggugacaggu guacuaaaau                                                   20


<210>  15127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15127
ccuuccagcc uuccgccuug                                                   20


<210>  15128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15128
caaggcggaa ggcuggaagg                                                   20


<210>  15129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15129
aauguccauu auaccacacu                                                   20


<210>  15130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15130
gcucccacuu cugagaacau                                                   20


<210>  15131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15131
cacuucugag aacauauagc                                                   20


<210>  15132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15132
gaagugggag cugagcugug                                                   20


<210>  15133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15133
cacuaccaga augugauugu                                                   20


<210>  15134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15134
ccaguacaaa uauuucaaaa                                                   20


<210>  15135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15135
uuauuuauuu auuuuuuuug                                                   20


<210>  15136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15136
aaaaaaauaa auaaauaaag                                                   20


<210>  15137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15137
uucuaugaug cccaggcugg                                                   20


<210>  15138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15138
agccugggca ucauagaaug                                                   20


<210>  15139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15139
gcucacugca gucucugccu                                                   20


<210>  15140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15140
cugcagucuc ugccucccag                                                   20


<210>  15141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15141
gccucccagg uucaagugau                                                   20


<210>  15142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15142
cagguucaag ugauucccac                                                   20


<210>  15143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15143
caggaagcug gaauuacagg                                                   20


<210>  15144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15144
ccuguaauuc cagcuuccug                                                   20


<210>  15145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15145
accaaaaaau acaaaaauua                                                   20


<210>  15146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15146
agcuccugac cucaagugau                                                   20


<210>  15147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15147
ugaccucaag ugauccaccu                                                   20


<210>  15148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15148
agugauccac cugccuuggc                                                   20


<210>  15149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15149
cgccuguaau cccagcacuu                                                   20


<210>  15150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15150
caaguaauca aagaaaugca                                                   20


<210>  15151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15151
uuucauuuac uuaauagguu                                                   20


<210>  15152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15152
gaauaggcaa gucauauaaa                                                   20


<210>  15153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15153
acaaacaaac aaacaaaaag                                                   20


<210>  15154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15154
gucuccacaa acaaacaaac                                                   20


<210>  15155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15155
cucugucacu caggcaggaa                                                   20


<210>  15156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15156
gucacucagg caggaaugca                                                   20


<210>  15157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15157
ggcaggaaug caguggugga                                                   20


<210>  15158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15158
uugcaacuau ugccuccugg                                                   20


<210>  15159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15159
uggguucaag cgauuuuccu                                                   20


<210>  15160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15160
gccucccaag uagcugggau                                                   20


<210>  15161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15161
caaguagcug ggauuacagg                                                   20


<210>  15162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15162
uguaauccca gcuacuuggg                                                   20


<210>  15163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15163
acuaaagaua caaaaauuag                                                   20


<210>  15164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15164
uggccucaag cggucccccu                                                   20


<210>  15165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15165
agcggucccc cugucucggc                                                   20


<210>  15166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15166
gccucccaaa gugcugggau                                                   20


<210>  15167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15167
caaagugcug ggauuacagg                                                   20


<210>  15168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15168
cgccuguaau cccagcacuu                                                   20


<210>  15169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15169
ugaucaaguc uccaugagga                                                   20


<210>  15170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15170
augaggaaag agacuuuaau                                                   20


<210>  15171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15171
uggagacuug aucaugagua                                                   20


<210>  15172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15172
uuccucaugg agacuugauc                                                   20


<210>  15173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15173
guaauacuuu uagaaacaau                                                   20


<210>  15174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15174
auuugaauuc aguuuagauu                                                   20


<210>  15175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15175
cagauggcaa agcuuaagcu                                                   20


<210>  15176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15176
gugcucagua cucuguggac                                                   20


<210>  15177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15177
guacucugug gacagacacu                                                   20


<210>  15178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15178
guggacagac acuguucagc                                                   20


<210>  15179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15179
uucuaaaccu ucugaucaac                                                   20


<210>  15180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15180
cgccuguaau ccagcacuau                                                   20


<210>  15181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15181
gccccccaua gugcuggauu                                                   20


<210>  15182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15182
ugauccaccc accucagccc                                                   20


<210>  15183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15183
ugaccucgug auccacccac                                                   20


<210>  15184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15184
ugaacuccug accucgugau                                                   20


<210>  15185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15185
acuaaaacua caaaaauuag                                                   20


<210>  15186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15186
ggaggcugag gcaggagaau                                                   20


<210>  15187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15187
ugaguagcug ggauuacagg                                                   20


<210>  15188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15188
gccuccugag uagcugggau                                                   20


<210>  15189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15189
ugccucagcc uccugaguag                                                   20


<210>  15190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15190
gccguccagg uucaagugau                                                   20


<210>  15191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15191
cugcaaccuc ugccguccag                                                   20


<210>  15192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15192
ggccugggcc acagagugac                                                   20


<210>  15193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15193
guggcccagg ccggaguaca                                                   20


<210>  15194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15194
aaaaaaaaaa aaaaagaaaa                                                   20


<210>  15195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15195
gacauaacug ggugcuguac                                                   20


<210>  15196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15196
ugcacccacu cggacauaac                                                   20


<210>  15197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15197
caugcaccca cucggacaua                                                   20


<210>  15198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15198
gggucacucu caugcaccca                                                   20


<210>  15199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15199
aaucucaggg ucacucucau                                                   20


<210>  15200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15200
gguggcguuc uucaagcacg                                                   20


<210>  15201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15201
cccccuuucu cagguggcgu                                                   20


<210>  15202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15202
gguuaccagc ggacaccacu                                                   20


<210>  15203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15203
cugcagaugg cuaagccaac                                                   20


<210>  15204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15204
ucccugcaga uggcuaagcc                                                   20


<210>  15205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15205
ccugugauag accacccucc                                                   20


<210>  15206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15206
ugccacggcc acuacuggau                                                   20


<210>  15207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15207
ugcaugagac gcagccucca                                                   20


<210>  15208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15208
ugcaugagaa guuucaggua                                                   20


<210>  15209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15209
aucucauuuc uccgucagca                                                   20


<210>  15210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15210
uuucuccguc agcacaauaa                                                   20


<210>  15211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15211
gucagcacaa uaaccaggua                                                   20


<210>  15212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15212
ggauguuuga guguagguca                                                   20


<210>  15213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15213
aacauccuga gcugaagcuu                                                   20


<210>  15214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15214
aaaugauaau auccuaucaa                                                   20


<210>  15215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15215
guauuuaagc ucugccacaa                                                   20


<210>  15216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15216
gccacaauca cucagcugug                                                   20


<210>  15217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15217
gcugugacac uguaaaucuc                                                   20


<210>  15218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15218
uaauaguuua uuacauucca                                                   20


<210>  15219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15219
uuaaagguaa cacaacuaaa                                                   20


<210>  15220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15220
ccaaaaaauc aacaggcaug                                                   20


<210>  15221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15221
caaaucacug aacuagugga                                                   20


<210>  15222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15222
acaauaaaug ugaaugauaa                                                   20


<210>  15223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15223
ccuaagaagc agauaagaau                                                   20


<210>  15224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15224
gcaagcuaga auucugaaga                                                   20


<210>  15225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15225
uuuuuucugc ugaguaacag                                                   20


<210>  15226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15226
gcagaaaaaa agaguaucau                                                   20


<210>  15227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15227
gcuuaucaaa uaucaaaguc                                                   20


<210>  15228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15228
cgccuguaau ccuaacacuu                                                   20


<210>  15229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15229
caaaguguua ggauuacagg                                                   20


<210>  15230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15230
agcgaccugc ccaccugggc                                                   20


<210>  15231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15231
gggguucaag accacccagg                                                   20


<210>  15232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15232
acucaaauac aaaaaauuag                                                   20


<210>  15233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15233
aauacaaaaa auuagccagg                                                   20


<210>  15234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15234
ggaggcugag ggaugagaau                                                   20


<210>  15235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15235
cgaguagcug ggauuacagg                                                   20


<210>  15236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15236
gccucccgag uagcugggau                                                   20


<210>  15237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15237
ucccucagcc ucccgaguag                                                   20


<210>  15238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15238
agugauucuc aucccucagc                                                   20


<210>  15239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15239
ggggcucaag ugauucucau                                                   20


<210>  15240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15240
gccuccgggg cucaagugau                                                   20


<210>  15241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15241
cugcaaccuc ugccuccggg                                                   20


<210>  15242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15242
cagcuugggc uacagaguga                                                   20


<210>  15243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15243
guagcccaag cugggagugc                                                   20


<210>  15244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15244
cucuguagcc caagcuggga                                                   20


<210>  15245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15245
gucucaaaaa aagacacaca                                                   20


<210>  15246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15246
aaaaaagaca cacacacaaa                                                   20


<210>  15247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15247
auguuuuuuu uguuugugug                                                   20


<210>  15248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15248
gauaauuucc uuuguuuaaa                                                   20


<210>  15249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15249
gaacuggcau uuucucucuu                                                   20


<210>  15250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15250
cuuggagaag auucaggaca                                                   20


<210>  15251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15251
uggagaagau ucaggacaaa                                                   20


<210>  15252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15252
aagagagaaa augccaguuc                                                   20


<210>  15253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15253
uuuaagauaa guagaagcag                                                   20


<210>  15254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15254
uucacugcuu cuacuuaucu                                                   20


<210>  15255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15255
guuggcaucu auuaauaaau                                                   20


<210>  15256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15256
caguuccaaa cuucagcagg                                                   20


<210>  15257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15257
ugacaauuca gcugugguca                                                   20


<210>  15258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15258
gcugcacaau uggucauugu                                                   20


<210>  15259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15259
uuaguuuugu ugagugucuc                                                   20


<210>  15260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15260
acaaaacuaa ggagauuaug                                                   20


<210>  15261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15261
guggacaaga cacugugagg                                                   20


<210>  15262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15262
cagugucuug uccacggaga                                                   20


<210>  15263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15263
aauuccuuua gaacacaugg                                                   20


<210>  15264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15264
cacggcacuu uuuugcauuc                                                   20


<210>  15265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15265
ucucccacgg cacuuuuuug                                                   20


<210>  15266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15266
acuucucauc ucccacggca                                                   20


<210>  15267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15267
ccuuacagcg uugccuacua                                                   20


<210>  15268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15268
cagucugccc cgaacacuuu                                                   20


<210>  15269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15269
cuuccuccca gucugccccg                                                   20


<210>  15270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15270
acuuuuaagu gaaacgggcu                                                   20


<210>  15271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15271
auauuuuugu uauuagaaua                                                   20


<210>  15272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15272
auauauucua auaacaaaaa                                                   20


<210>  15273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15273
ugaaagguua uuuuccauag                                                   20


<210>  15274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15274
ugaacuaauc acaucaacca                                                   20


<210>  15275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15275
ggugguugau gugauuaguu                                                   20


<210>  15276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15276
caguaagucu cuuucuugau                                                   20


<210>  15277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15277
uucuugaucg gucuuacuga                                                   20


<210>  15278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15278
ccguaagaug accauacaac                                                   20


<210>  15279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15279
uacuuaucca ugaggcuugc                                                   20


<210>  15280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15280
uggauaagua agagcuguaa                                                   20


<210>  15281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15281
gcuuacucca ggaauguaaa                                                   20


<210>  15282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15282
aggaauguaa augacuaugu                                                   20


<210>  15283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15283
ugccuguaau cccagcacuu                                                   20


<210>  15284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15284
caaagugcug ggauuacagg                                                   20


<210>  15285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15285
cuugagguca ggagucggau                                                   20


<210>  15286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15286
agugagcccc caaccuuggc                                                   20


<210>  15287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15287
ugaccucaag ugagccccca                                                   20


<210>  15288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15288
acuaaaaaua caaaaauuag                                                   20


<210>  15289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15289
ggaggcugag gcaggagaau                                                   20


<210>  15290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15290
ugaguagcug ggauuacagg                                                   20


<210>  15291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15291
gccuccugag uagcugggau                                                   20


<210>  15292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15292
ugccucagcc uccugaguag                                                   20


<210>  15293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15293
cagguucaag cgauucuccu                                                   20


<210>  15294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15294
accucccagg uucaagcgau                                                   20


<210>  15295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15295
cugcaaccuc uaccucccag                                                   20


<210>  15296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15296
gcucacugca accucuaccu                                                   20


<210>  15297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15297
agccugugca auagagcgag                                                   20


<210>  15298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15298
auugcacagg cuggagugca                                                   20


<210>  15299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15299
cucuauugca caggcuggag                                                   20


<210>  15300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15300
gucucaaaaa aaaaaaaaaa                                                   20


<210>  15301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15301
aaaaaaaaaa aaaaaaaaga                                                   20


<210>  15302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15302
gugaccuggu aauauauacu                                                   20


<210>  15303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15303
aaaaaaaaau aauaaaauua                                                   20


<210>  15304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15304
gucucaaaaa aaaaauaaua                                                   20


<210>  15305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15305
uguugcccag gcuggagugc                                                   20


<210>  15306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15306
agccugggca acaagagcaa                                                   20


<210>  15307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15307
gcucaccaca accuccaccu                                                   20


<210>  15308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15308
ccacaaccuc caccucccgg                                                   20


<210>  15309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15309
accucccggg uucaagcaau                                                   20


<210>  15310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15310
cggguucaag caauucuccu                                                   20


<210>  15311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15311
ugccucagcc uccugaguag                                                   20


<210>  15312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15312
gccuccugag uagcugggau                                                   20


<210>  15313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15313
ugaguagcug ggauuacagg                                                   20


<210>  15314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15314
ggaggcugag gcaggagaau                                                   20


<210>  15315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15315
acuaaaaaua caaaauuagc                                                   20


<210>  15316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15316
auguugguca ggcuggucuc                                                   20


<210>  15317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15317
aacucccaac cucaggugau                                                   20


<210>  15318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15318
caaccucagg ugauccgccc                                                   20


<210>  15319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15319
ggugauccgc ccuccucgac                                                   20


<210>  15320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15320
ucgacccccc aaagugcugg                                                   20


<210>  15321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15321
accccccaaa gugcugggau                                                   20


<210>  15322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15322
caccuguaau cccagcacuu                                                   20


<210>  15323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15323
aaagcaucac acuauauacu                                                   20


<210>  15324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15324
auauuguuaa aaauucucca                                                   20


<210>  15325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15325
auauuacaau ccagauuaua                                                   20


<210>  15326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15326
cacuggcaga uaaucaccaa                                                   20


<210>  15327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15327
aauuuucuaa aaugagcaag                                                   20


<210>  15328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15328
uuuuagaaaa uuugagaaua                                                   20


<210>  15329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15329
aaaaauaaaa auaaaaaggu                                                   20


<210>  15330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15330
cucuguugcc caggcuagag                                                   20


<210>  15331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15331
guugcccagg cuagagcaca                                                   20


<210>  15332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15332
agccugggca acagagugag                                                   20


<210>  15333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15333
cugcagccuc cgcuuccugg                                                   20


<210>  15334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15334
gcuuccuggg uucaaaugau                                                   20


<210>  15335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15335
ggccccagcc uccugagugg                                                   20


<210>  15336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15336
ugaguggcug gaauuacagg                                                   20


<210>  15337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15337
ggaggcuggg gccagagaau                                                   20


<210>  15338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15338
acuaaaaaua caaaaauuag                                                   20


<210>  15339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15339
aacuccugac cucgugaucc                                                   20


<210>  15340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15340
ugaccucgug auccacccac                                                   20


<210>  15341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15341
ugauccaccc accucggccu                                                   20


<210>  15342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15342
gccucccaaa gugcugggau                                                   20


<210>  15343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15343
caaagugcug ggauuacagg                                                   20


<210>  15344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15344
cgccuguaau cccagcacuu                                                   20


<210>  15345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15345
cugaccagcc ugcagaaacc                                                   20


<210>  15346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15346
agcuuaccac aucgucuccc                                                   20


<210>  15347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15347
gcuccuaagg augugcaggg                                                   20


<210>  15348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15348
uaaggaugug caggggcagu                                                   20


<210>  15349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15349
acugccccug cacauccuua                                                   20


<210>  15350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15350
caacugcccc ugcacauccu                                                   20


<210>  15351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15351
cacccuuccg ccucucaacu                                                   20


<210>  15352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15352
cuucauuggg auauaauugc                                                   20


<210>  15353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15353
ucauugggau auaauugcca                                                   20


<210>  15354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15354
aacacguguu aucagaaugg                                                   20


<210>  15355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15355
guuuucuucu cauuguuugu                                                   20


<210>  15356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15356
uuguuuguac uuuuuauaaa                                                   20


<210>  15357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15357
uguuacccuu uauaaaaagu                                                   20


<210>  15358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15358
guuuggaugc ugugaagcuu                                                   20


<210>  15359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15359
aaaugcaaac ugggaaggca                                                   20


<210>  15360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15360
guauauauua auaguugucu                                                   20


<210>  15361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15361
cacagcuaau auagcagaaa                                                   20


<210>  15362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15362
ugucacuagu cucacacagc                                                   20


<210>  15363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15363
uuagcuugac ucuuuccaaa                                                   20


<210>  15364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15364
uuccaaaauu auuugcugug                                                   20


<210>  15365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15365
aguagauggc ccuacuagca                                                   20


<210>  15366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15366
agcauucagg aauaggcuuu                                                   20


<210>  15367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15367
guaauugaua cacaaaauga                                                   20


<210>  15368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15368
caucacauuu gagaaguaaa                                                   20


<210>  15369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15369
aaugugaugu gagucaccaa                                                   20


<210>  15370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15370
agaaugauug cuuucccacc                                                   20


<210>  15371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15371
cauacagacu gagcagcuac                                                   20


<210>  15372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15372
gucuguaugu gaggaaggug                                                   20


<210>  15373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15373
aaugccaaag uugcccagaa                                                   20


<210>  15374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15374
uuucugcauc uguucacaag                                                   20


<210>  15375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15375
uaaauaucaa ccccuuguga                                                   20


<210>  15376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15376
auauccauuc uauguucucu                                                   20


<210>  15377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15377
uaaugcucag ucagcaccuc                                                   20


<210>  15378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15378
gucagcaccu caggugguug                                                   20


<210>  15379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15379
ggugguugga guucaaugcu                                                   20


<210>  15380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15380
aaccaccuga ggugcugacu                                                   20


<210>  15381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15381
auccccuaga aaagacagug                                                   20


<210>  15382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15382
aauaagcagg acuacccagg                                                   20


<210>  15383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15383
uuauuacuau ggaaaaauag                                                   20


<210>  15384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15384
uuuauuuugu gccuguuuac                                                   20


<210>  15385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15385
auggcauuaa caugcccaaa                                                   20


<210>  15386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15386
ucuccaguuc agcagaacca                                                   20


<210>  15387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15387
aguucagcag aaccauuguc                                                   20


<210>  15388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15388
aaugauuuuu auggagcucu                                                   20


<210>  15389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15389
auaaaaauca uuugagaaau                                                   20


<210>  15390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15390
gauuuauagg aaagauguua                                                   20


<210>  15391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15391
gaaauuguuu uauuuuuaau                                                   20


<210>  15392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15392
uggaauugca agagaaagga                                                   20


<210>  15393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15393
ugcaauucca agaggaaggc                                                   20


<210>  15394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15394
ggaagcagac auuugcaaag                                                   20


<210>  15395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15395
acugagugcc ucagaugagu                                                   20


<210>  15396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15396
guggaggcac ucuggaagca                                                   20


<210>  15397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15397
gaugagucua ggaagagcug                                                   20


<210>  15398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15398
ucugaggcac ucaguggagg                                                   20


<210>  15399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15399
uccuagacuc aucugaggca                                                   20


<210>  15400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15400
cgucagcuug guucccauug                                                   20


<210>  15401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15401
ucagcuuggu ucccauugga                                                   20


<210>  15402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15402
cagcccauca agaugcuuug                                                   20


<210>  15403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15403
gcccaucaag augcuuugau                                                   20


<210>  15404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15404
guaccaguac cugcaagcaa                                                   20


<210>  15405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15405
aggacuugga uuuugauuuc                                                   20


<210>  15406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15406
ccacccccau ucccccuaag                                                   20


<210>  15407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15407
uaugcucacc acccccauuc                                                   20


<210>  15408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15408
gcacagaaca gcugccaacu                                                   20


<210>  15409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15409
ucccaauaua gccccucagu                                                   20


<210>  15410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15410
guuaacuaca aguaaacuca                                                   20


<210>  15411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15411
uuuugaauuu cauuuuaaug                                                   20


<210>  15412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15412
cucgggcacu gggauguuaa                                                   20


<210>  15413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15413
ggcacuggga uguuaagaaa                                                   20


<210>  15414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15414
aguuaguuuu agauuagagg                                                   20


<210>  15415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15415
aaucuaaaac uaacuugaga                                                   20


<210>  15416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15416
gugugaccac ugcacuuuug                                                   20


<210>  15417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15417
ccuugggcag auuuaugggc                                                   20


<210>  15418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15418
uugggcagau uuaugggcug                                                   20


<210>  15419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15419
uuccuaccag cccauaaauc                                                   20


<210>  15420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15420
guguugugcu cuuuccuacc                                                   20


<210>  15421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15421
ccguguugug cucuuuccua                                                   20


<210>  15422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15422
auuaucaucg ccaaggugcu                                                   20


<210>  15423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15423
gucuuccuug cuggccacau                                                   20


<210>  15424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15424
caaaaucaau uucaauggac                                                   20


<210>  15425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15425
augaaagaau uggggccugu                                                   20


<210>  15426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15426
uauagccccc ugaagcaaau                                                   20


<210>  15427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15427
ccuauagccc ccugaagcaa                                                   20


<210>  15428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15428
ucuuuuaguc ccuuucacga                                                   20


<210>  15429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15429
agcccauguu caaguuggau                                                   20


<210>  15430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15430
uccagcccau guucaaguug                                                   20


<210>  15431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15431
cuaccuucuc cuccagccca                                                   20


<210>  15432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15432
ggagauuaau guugaugcua                                                   20


<210>  15433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15433
ugagucuccc uaccuucucc                                                   20


<210>  15434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15434
uacaaucagu gucuucccua                                                   20


<210>  15435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15435
uucauucucu uacaaucagu                                                   20


<210>  15436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15436
aacugaaacu gauguuuccc                                                   20


<210>  15437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15437
caacauaggg ucuuaaauga                                                   20


<210>  15438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15438
acauaggguc uuaaaugacu                                                   20


<210>  15439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15439
accccaauag caugggaagg                                                   20


<210>  15440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15440
ccaccccaau agcaugggaa                                                   20


<210>  15441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15441
caaaucucug agaaguucau                                                   20


<210>  15442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15442
gagaaguuca ugggccucug                                                   20


<210>  15443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15443
gagauuuggg agcacuggcu                                                   20


<210>  15444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15444
gaagaagaag ccaacccagc                                                   20


<210>  15445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15445
ugcuuggugg cugcuggguu                                                   20


<210>  15446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15446
ucuugcuugg uggcugcugg                                                   20


<210>  15447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15447
accaugggca ccagggcccg                                                   20


<210>  15448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15448
ucucucaccu gcugaaggug                                                   20


<210>  15449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15449
caccugcuga aggugauuaa                                                   20


<210>  15450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15450
ccugcugaag gugauuaaca                                                   20


<210>  15451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15451
uggacccgca auaaagguaa                                                   20


<210>  15452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15452
uuuugcuuua aaugaacaaa                                                   20


<210>  15453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15453
gauugugaca cuaaauuuaa                                                   20


<210>  15454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15454
ugccuguuau uccagcacuu                                                   20


<210>  15455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15455
caaagugcug gaauaacagg                                                   20


<210>  15456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15456
gucucccaaa gugcuggaau                                                   20


<210>  15457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15457
agugauccac uugccucagu                                                   20


<210>  15458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15458
uggccucaag ugauccacuu                                                   20


<210>  15459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15459
aacucuuggc cucaagugau                                                   20


<210>  15460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15460
cuacuaaaaa uacaaaaaau                                                   20


<210>  15461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15461
acuaaaaaua caaaaaauua                                                   20


<210>  15462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15462
agccuguaau cccagcacuu                                                   20


<210>  15463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15463
caaagugcug ggauuacagg                                                   20


<210>  15464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15464
gccucccaaa gugcugggau                                                   20


<210>  15465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15465
ugauccgccc accucggccu                                                   20


<210>  15466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15466
ugaccucgug auccgcccac                                                   20


<210>  15467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15467
acuaaaaaua caaaaaaauu                                                   20


<210>  15468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15468
gauaauuuuu uuguauuuuu                                                   20


<210>  15469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15469
ggaggcugag gcaggagaau                                                   20


<210>  15470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15470
cgagcagcug ggacuacagg                                                   20


<210>  15471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15471
gccucccgag cagcugggac                                                   20


<210>  15472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15472
ugccucagcc ucccgagcag                                                   20


<210>  15473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15473
cggauucacg ccauucuccu                                                   20


<210>  15474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15474
gccucccgga uucacgccau                                                   20


<210>  15475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15475
cugcaagcuc cgccucccgg                                                   20


<210>  15476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15476
gcucacugca agcuccgccu                                                   20


<210>  15477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15477
agccugggug acagagcgag                                                   20


<210>  15478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15478
gucacccagg cuggagugca                                                   20


<210>  15479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15479
cucugucacc caggcuggag                                                   20


<210>  15480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15480
gucucaaaaa aaaaauuaga                                                   20


<210>  15481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15481
aaaaaaaaau uagaugggca                                                   20


<210>  15482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15482
caaguagcug ggauuacagg                                                   20


<210>  15483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15483
gccucccaag uagcugggau                                                   20


<210>  15484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15484
ugccucagcc ucccaaguag                                                   20


<210>  15485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15485
cuugccucag ccucccaagu                                                   20


<210>  15486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15486
cagguucaag caacucucuu                                                   20


<210>  15487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15487
gccucccagg uucaagcaac                                                   20


<210>  15488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15488
agccugggug acagagucag                                                   20


<210>  15489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15489
gucacccagg cuggagugca                                                   20


<210>  15490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15490
uuccaaaaga agaaaaaaau                                                   20


<210>  15491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15491
uuuaguauca ucagucacug                                                   20


<210>  15492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15492
uagggauaac agugacugau                                                   20


<210>  15493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15493
gaauugaugu uccuggccaa                                                   20


<210>  15494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15494
uugcugucuc cuuaaaucuu                                                   20


<210>  15495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15495
uuaaaucuug guuaauggcu                                                   20


<210>  15496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15496
auaacuaugc uagccaggac                                                   20


<210>  15497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15497
gggacaguuu ugcuuuucug                                                   20


<210>  15498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15498
aaaaaaaaaa aaaaaaaaag                                                   20


<210>  15499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15499
aucucaaaaa aaaaaaaaaa                                                   20


<210>  15500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15500
agcccaggca acaagaauga                                                   20


<210>  15501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15501
gcucacugca acuucugccu                                                   20


<210>  15502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15502
cugcaacuuc ugccuccugg                                                   20


<210>  15503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15503
uggguucaaa cgauucuucu                                                   20


<210>  15504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15504
gccucucgag gcagauuaca                                                   20


<210>  15505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15505
cgaggcagau uacagcuggg                                                   20


<210>  15506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15506
aggcagauua cagcugggau                                                   20


<210>  15507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15507
agaggcugag gcagaagaau                                                   20


<210>  15508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15508
acuaaaacua caaaaaaauu                                                   20


<210>  15509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15509
aacuccugac cugaagugau                                                   20


<210>  15510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15510
ugaccugaag ugaucuaucc                                                   20


<210>  15511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15511
caaaguguug ggauuacggg                                                   20


<210>  15512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15512
ugcccguaau cccaacacuu                                                   20


<210>  15513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15513
cucuuugccu ugucuucuac                                                   20


<210>  15514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15514
cuuugccuug ucuucuaccu                                                   20


<210>  15515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15515
uugccuuguc uucuaccuuu                                                   20


<210>  15516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15516
cuacuaacuu cccauucucc                                                   20


<210>  15517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15517
uuuagcugcc aucagucuuc                                                   20


<210>  15518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15518
cuucucugca aacaucucug                                                   20


<210>  15519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15519
gcaaacaucu cuggagaguc                                                   20


<210>  15520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15520
ggagaguccc agccucagcc                                                   20


<210>  15521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15521
agagauguuu gcagagaagg                                                   20


<210>  15522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15522
ccagagaugu uugcagagaa                                                   20


<210>  15523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15523
gcccacagag cuucccacug                                                   20


<210>  15524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15524
gugggcugag gcugggacuc                                                   20


<210>  15525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15525
gagguggacc uuguuugcaa                                                   20


<210>  15526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15526
gagcaguggg aagcucugug                                                   20


<210>  15527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15527
cuuggccugg acccugucua                                                   20


<210>  15528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15528
uggccuggac ccugucuacu                                                   20


<210>  15529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15529
auagcagcgu uucccgccca                                                   20


<210>  15530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15530
gggcacugcu cugguccugc                                                   20


<210>  15531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15531
gguccugccu gccuuucccu                                                   20


<210>  15532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15532
uuguauccug caggcugcua                                                   20


<210>  15533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15533
agaugggggu agcagccugc                                                   20


<210>  15534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15534
ucaguuggcu uucagagggc                                                   20


<210>  15535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15535
gaaagccaac ugaagaggac                                                   20


<210>  15536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15536
uggguguucc cuuacccacu                                                   20


<210>  15537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15537
ccagucacug gguucagucc                                                   20


<210>  15538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15538
guccuaggcc gucuucucuc                                                   20


<210>  15539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15539
cuuuguaguc ucugggccag                                                   20


<210>  15540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15540
uuguagucuc ugggccagug                                                   20


<210>  15541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15541
gggccagugc uguucuagag                                                   20


<210>  15542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15542
agaacagcac uggcccagag                                                   20


<210>  15543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15543
cuagaacagc acuggcccag                                                   20


<210>  15544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15544
auagcuaugc caggcaagac                                                   20


<210>  15545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15545
acagcuauau guguuuagug                                                   20


<210>  15546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15546
aguauugggc agggcagccu                                                   20


<210>  15547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15547
ggcugcccug cccaauacug                                                   20


<210>  15548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15548
caggcugccc ugcccaauac                                                   20


<210>  15549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15549
ugucuucagu gucuagauga                                                   20


<210>  15550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15550
ucuagacacu gaagacagga                                                   20


<210>  15551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15551
gaggaccugu cucuggagcu                                                   20


<210>  15552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15552
gaggucccuc aucuagacac                                                   20


<210>  15553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15553
ggagcugcag uucaauguag                                                   20


<210>  15554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15554
agagacaggu ccucugaggu                                                   20


<210>  15555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15555
ucacaccgug ucugacauau                                                   20


<210>  15556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15556
gcuuucuguc cuccucccca                                                   20


<210>  15557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15557
uccccacauc ugccccugcc                                                   20


<210>  15558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15558
ccacaucugc cccugcccca                                                   20


<210>  15559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15559
ccaagucuuu uguuuccccu                                                   20


<210>  15560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15560
caaaauauuu aguaggggaa                                                   20


<210>  15561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15561
guuaaaaacc ggacugcagg                                                   20


<210>  15562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15562
cgccuguaau uccagaacuu                                                   20


<210>  15563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15563
caaaguucug gaauuacagg                                                   20


<210>  15564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15564
gccucccaaa guucuggaau                                                   20


<210>  15565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15565
ugaccuugug augcacuggu                                                   20


<210>  15566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15566
aucuccugac cuugugaugc                                                   20


<210>  15567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15567
cacggugaaa ccccgucucu                                                   20


<210>  15568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15568
acuaaaaaua caaaaaaaaa                                                   20


<210>  15569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15569
cagguagcug ggacuauggg                                                   20


<210>  15570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15570
ugcaucagcc ucccagguag                                                   20


<210>  15571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15571
cagguucacg ccguucuccu                                                   20


<210>  15572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15572
gccucccagg uucacgccgu                                                   20


<210>  15573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15573
cugcaagcuc cgccucccag                                                   20


<210>  15574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15574
gcucacugca agcuccgccu                                                   20


<210>  15575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15575
agccugggcg acagagcgag                                                   20


<210>  15576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15576
gucgcccagg cuggagugca                                                   20


<210>  15577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15577
cucugucgcc caggcuggag                                                   20


<210>  15578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15578
gucucaaaaa caaaacaaaa                                                   20


<210>  15579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15579
aaaacaaaac aaaacaaaaa                                                   20


<210>  15580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15580
cuucuuccug ugcagccugg                                                   20


<210>  15581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15581
gaugguaaug cuugcucacu                                                   20


<210>  15582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15582
aucuccucuc aggccagugg                                                   20


<210>  15583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15583
ucucaggcca gugguggcau                                                   20


<210>  15584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15584
caggccagug guggcauuag                                                   20


<210>  15585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15585
ggccaguggu ggcauuagau                                                   20


<210>  15586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15586
uaggagcgug uaugaguucg                                                   20


<210>  15587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15587
uaugagaauc uaaugccacc                                                   20


<210>  15588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15588
uacacgcucc uaugagaauc                                                   20


<210>  15589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15589
cacuucugua aagacauacc                                                   20


<210>  15590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15590
gguaugucuu uacagaagug                                                   20


<210>  15591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15591
uuucuuuaua ugucucaggu                                                   20


<210>  15592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15592
caguucugca ggcuguacag                                                   20


<210>  15593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15593
ggaaacuugc agucauggca                                                   20


<210>  15594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15594
uuuuccugug ggccauguga                                                   20


<210>  15595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15595
cuuuuuccug ugggccaugu                                                   20


<210>  15596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15596
uucucucuuu uuccuguggg                                                   20


<210>  15597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15597
ccuucucucu uuuuccugug                                                   20


<210>  15598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15598
cuccuucucu cuuuuuccug                                                   20


<210>  15599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15599
cucuccuucu cucuuuuucc                                                   20


<210>  15600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15600
cucucuccuu cucucuuuuu                                                   20


<210>  15601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15601
cucucucucc uucucucuuu                                                   20


<210>  15602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15602
cucucucucu ccuucucucu                                                   20


<210>  15603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15603
gucucucucu cucucuccuu                                                   20


<210>  15604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15604
cugucucucu cucucucucc                                                   20


<210>  15605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15605
cucugucucu cucucucucu                                                   20


<210>  15606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15606
cucucugucu cucucucucu                                                   20


<210>  15607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15607
cucucucugu cucucucucu                                                   20


<210>  15608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15608
cucucucucu gucucucucu                                                   20


<210>  15609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15609
aucuuucuuu uucucucucu                                                   20


<210>  15610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15610
caaucuuucu uuuucucucu                                                   20


<210>  15611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15611
cucucaaucu uucuuuuucu                                                   20


<210>  15612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15612
cccucucaau cuuucuuuuu                                                   20


<210>  15613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15613
cucccucuca aucuuucuuu                                                   20


<210>  15614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15614
ucucucccuc ucaaucuuuc                                                   20


<210>  15615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15615
cuccucucuc ccucucaauc                                                   20


<210>  15616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15616
uuucucccuc cucucucccu                                                   20


<210>  15617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15617
ccuuucuccc uccucucucc                                                   20


<210>  15618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15618
cccuacaggc acucuccuuu                                                   20


<210>  15619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15619
uuuguguagc aacucccccu                                                   20


<210>  15620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15620
accauuagaa acuaccccca                                                   20


<210>  15621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15621
caccaggccc caccuccgac                                                   20


<210>  15622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15622
gacacuggag auuacaauuc                                                   20


<210>  15623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15623
agugucggag guggggccug                                                   20


<210>  15624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15624
ugcugaauug uaaucuccag                                                   20


<210>  15625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15625
guguccccac ccaaaucuca                                                   20


<210>  15626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15626
gauaugguuu ggcucugugu                                                   20


<210>  15627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15627
aaugugcagu ucacaauagg                                                   20


<210>  15628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15628
uuaugagaau cuaaugccug                                                   20


<210>  15629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15629
uaaggagcau gcaaccuaga                                                   20


<210>  15630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15630
aaucaucauc aggcauuaga                                                   20


<210>  15631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15631
gcacauaugc augcaccugu                                                   20


<210>  15632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15632
gccacuucug guccagacug                                                   20


<210>  15633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15633
uuuggauuac ugcacuagcc                                                   20


<210>  15634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15634
aaaaaauuaa auuaaauuuu                                                   20


<210>  15635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15635
aagcugggca acagaaugac                                                   20


<210>  15636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15636
cugcggccuc gaucucccag                                                   20


<210>  15637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15637
aucucccagg cucaagugau                                                   20


<210>  15638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15638
caggcucaag ugauccuucu                                                   20


<210>  15639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15639
agugauccuu cugccucagc                                                   20


<210>  15640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15640
gccuucucag uaguugggac                                                   20


<210>  15641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15641
guaguuggga cuacaggcau                                                   20


<210>  15642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15642
aaaaaaaaaa aaaaucaaaa                                                   20


<210>  15643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15643
gucucaaaaa aaaaaaaaaa                                                   20


<210>  15644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15644
gccugucgcc caggcuggag                                                   20


<210>  15645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15645
agccugggcg acaggcugag                                                   20


<210>  15646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15646
gcucacugca acuucugccu                                                   20


<210>  15647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15647
cugcaacuuc ugccucccag                                                   20


<210>  15648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15648
cagguucaag ugauucuccu                                                   20


<210>  15649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15649
ugccucagcc ucccgaguag                                                   20


<210>  15650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15650
gccucccgag uaguugggau                                                   20


<210>  15651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15651
cgaguaguug ggauuacagg                                                   20


<210>  15652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15652
ggaggcugag gcaggagaau                                                   20


<210>  15653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15653
acuaaaaaua caaaaaguua                                                   20


<210>  15654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15654
aacuugugac cucgugauua                                                   20


<210>  15655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15655
ugauuagccc gccucggccu                                                   20


<210>  15656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15656
gccucccaaa gugcugggau                                                   20


<210>  15657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15657
caaagugcug ggauuacagg                                                   20


<210>  15658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15658
cgccuguaau cccagcacuu                                                   20


<210>  15659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15659
cagccaggaa acagcauucu                                                   20


<210>  15660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15660
agaaugcugu uuccuggcug                                                   20


<210>  15661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15661
uuaguaugcc cacagaguug                                                   20


<210>  15662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15662
gugggcauac uaaagagaau                                                   20


<210>  15663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15663
guacucuuua cccaaaaccu                                                   20


<210>  15664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15664
uuacccaaaa ccuccaugcc                                                   20


<210>  15665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15665
augccuccag cugcaggcag                                                   20


<210>  15666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15666
agcugcaggc agccacuaac                                                   20


<210>  15667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15667
gugacucuac gucuucugga                                                   20


<210>  15668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15668
acgucuucug gacauuacug                                                   20


<210>  15669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15669
uacagucagu gagcuuguga                                                   20


<210>  15670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15670
cugacuguau gagcccaucc                                                   20


<210>  15671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15671
cuguuuuucu uuuuuuuuua                                                   20


<210>  15672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15672
guuuuucuuu uuuuuuuaaa                                                   20


<210>  15673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15673
cggguucaag cgauucuccu                                                   20


<210>  15674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15674
ugccucagcc ucccgagugg                                                   20


<210>  15675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15675
gccucccgag uggcugggac                                                   20


<210>  15676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15676
cgaguggcug ggacuacagg                                                   20


<210>  15677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15677
ggaggcugag gcaggagaau                                                   20


<210>  15678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15678
acuaaaaaaa aaaaaaaaaa                                                   20


<210>  15679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15679
aucuccugac uucaugaucc                                                   20


<210>  15680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15680
ugacuucaug auccgccugc                                                   20


<210>  15681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15681
gccucccaaa gugcugggau                                                   20


<210>  15682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15682
caaagugcug ggauuacagg                                                   20


<210>  15683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15683
cgccuguaau cccagcacuu                                                   20


<210>  15684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15684
cacuucugga gguugggaag                                                   20


<210>  15685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15685
agaaguguga gaaguaaauu                                                   20


<210>  15686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15686
uguggugagg gggugaggaa                                                   20


<210>  15687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15687
ccacaugagg gcaaggcgaa                                                   20


<210>  15688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15688
cccccucacc acaugagggc                                                   20


<210>  15689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15689
guggggccuc uuauauaugg                                                   20


<210>  15690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15690
uauauaugga ugcuaaucuc                                                   20


<210>  15691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15691
uucaugaggg gucugcccuc                                                   20


<210>  15692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15692
ugaaugagau uagcauccau                                                   20


<210>  15693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15693
ugacccaguc accucccaaa                                                   20


<210>  15694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15694
caaaggcccc accuccuaau                                                   20


<210>  15695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15695
uaauaccauc acccugguaa                                                   20


<210>  15696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15696
cugaucuuag aaaagugcuu                                                   20


<210>  15697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15697
cucccugauc uuagaaaagu                                                   20


<210>  15698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15698
gcuacuuacu cacucccuga                                                   20


<210>  15699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15699
auuccacaug ucagucaucu                                                   20


<210>  15700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15700
gcuccaugau ggcugccucc                                                   20


<210>  15701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15701
augauggcug ccuccuagag                                                   20


<210>  15702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15702
uagagcauug ggagucucga                                                   20


<210>  15703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15703
aggaggcagc caucauggag                                                   20


<210>  15704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15704
caaugcucua ggaggcagcc                                                   20


<210>  15705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15705
auguucuaua ugcucucaug                                                   20


<210>  15706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15706
cauguguugu guauuggaga                                                   20


<210>  15707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15707
uguguugugu auuggagaua                                                   20


<210>  15708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15708
aauacacaac acaugagagc                                                   20


<210>  15709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15709
acuaucucca auacacaaca                                                   20


<210>  15710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15710
gagccuguuu ccucuuuuag                                                   20


<210>  15711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15711
gagaugaagu aacuuauuca                                                   20


<210>  15712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15712
uuuagaaaca ggaguuuaaa                                                   20


<210>  15713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15713
uguuucuaaa agaggaaaca                                                   20


<210>  15714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15714
ugccuguaau uccagcacuu                                                   20


<210>  15715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15715
caaagugcug gaauuacagg                                                   20


<210>  15716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15716
gccucccaaa gugcuggaau                                                   20


<210>  15717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15717
caucucagcc ucccaaagug                                                   20


<210>  15718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15718
agugauccuc ccaucucagc                                                   20


<210>  15719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15719
aagcuccagu gauccuccca                                                   20


<210>  15720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15720
aacuccaagc uccagugauc                                                   20


<210>  15721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15721
cacuaugaug cccaggcugg                                                   20


<210>  15722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15722
ucaagaaauu aaaaaauuag                                                   20


<210>  15723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15723
agaaauuaaa aaauuagcug                                                   20


<210>  15724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15724
ggaggcugag gugggaggau                                                   20


<210>  15725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15725
agaguagaug ggaccacagg                                                   20


<210>  15726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15726
gccuccagag uagaugggac                                                   20


<210>  15727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15727
caccucagcc uccagaguag                                                   20


<210>  15728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15728
agcaauccuc ccaccucagc                                                   20


<210>  15729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15729
ugggcucaag caauccuccc                                                   20


<210>  15730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15730
accuccuggg cucaagcaau                                                   20


<210>  15731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15731
ucacccagga uggggugcaa                                                   20


<210>  15732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15732
cucgucaccc aggauggggu                                                   20


<210>  15733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15733
aaaaagaaaa aaaaaaugcu                                                   20


<210>  15734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15734
aacagcaaac aaccagggca                                                   20


<210>  15735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15735
cugagggcuc cuuccaucuu                                                   20


<210>  15736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15736
gggagccccc aggcccaugc                                                   20


<210>  15737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15737
uuccaucuuc aacucauucu                                                   20


<210>  15738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15738
uucucugugc accuguuagg                                                   20


<210>  15739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15739
gugcaccugu uaggaaguug                                                   20


<210>  15740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15740
uuuuguucuu ggacccugau                                                   20


<210>  15741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15741
uuuuaauaaa ugguaaaacc                                                   20


<210>  15742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15742
aacaaacccc ccuucucuaa                                                   20


<210>  15743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15743
aagucccauc cgacgaaagg                                                   20


<210>  15744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15744
uuccccuuuc gucggauggg                                                   20


<210>  15745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15745
ugguucuuuc uccuuccccu                                                   20


<210>  15746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15746
acgguacaga ugcuuguucu                                                   20


<210>  15747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15747
cugccuuucu ugggacucaa                                                   20


<210>  15748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15748
cuuccccacg cuguuuccua                                                   20


<210>  15749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15749
ugucccuccc uuccccacgc                                                   20


<210>  15750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15750
aaaacaccaa guuacuuaaa                                                   20


<210>  15751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15751
cuuuacugau guguauuaua                                                   20


<210>  15752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15752
cacuuuacug auguguauua                                                   20


<210>  15753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15753
aggugcgguu caagauauua                                                   20


<210>  15754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15754
aggcuuccag cccuagcaug                                                   20


<210>  15755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15755
augcuagggc uggaagccug                                                   20


<210>  15756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15756
ccuaugcuuc ccugguugca                                                   20


<210>  15757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15757
uaugcuuccc ugguugcagg                                                   20


<210>  15758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15758
agccaucacc ugcaaccagg                                                   20


<210>  15759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15759
ccagccauca ccugcaacca                                                   20


<210>  15760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15760
ugauuuucag uaagggaagu                                                   20


<210>  15761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15761
cuacaucuau uccuaagcau                                                   20


<210>  15762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15762
uccaaaugua aauauuccau                                                   20


<210>  15763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15763
ccuuuagcuc uuccaaaugu                                                   20


<210>  15764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15764
cgccuuuagc ucuuccaaau                                                   20


<210>  15765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15765
gaugacuuua uccccacuuu                                                   20


<210>  15766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15766
aacucagaug acuuuauccc                                                   20


<210>  15767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15767
uccaacucag augacuuuau                                                   20


<210>  15768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15768
aaacuuguga augguuuaag                                                   20


<210>  15769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15769
cggugggcag uggcaggggc                                                   20


<210>  15770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15770
gugggcagug gcaggggcag                                                   20


<210>  15771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15771
ugccccugcc acugcccacc                                                   20


<210>  15772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15772
ccugccccug ccacugccca                                                   20


<210>  15773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15773
ucuccugccc cugccacugc                                                   20


<210>  15774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15774
gcuaucuggg acgccuggcc                                                   20


<210>  15775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15775
cuccagaccc auucucacgc                                                   20


<210>  15776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15776
agacccauuc ucacgcuguc                                                   20


<210>  15777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15777
cgcugucucu uggcacccag                                                   20


<210>  15778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15778
uggcacccag gggccaguga                                                   20


<210>  15779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15779
cauuuguuuu guguauauag                                                   20


<210>  15780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15780
aaaaaauaaa uaaauaaaau                                                   20


<210>  15781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15781
gucucaaaaa aauaaauaaa                                                   20


<210>  15782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15782
cucugucacc caggcuggag                                                   20


<210>  15783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15783
gucacccagg cuggagugca                                                   20


<210>  15784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15784
agccugggug acagagugag                                                   20


<210>  15785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15785
gcucagugca agcucugccu                                                   20


<210>  15786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15786
gugcaagcuc ugccuccugg                                                   20


<210>  15787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15787
gccuccuggg uucaagcaau                                                   20


<210>  15788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15788
uggguucaag caauucuccu                                                   20


<210>  15789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15789
ugccucagcc uccugaguag                                                   20


<210>  15790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15790
gccuccugag uagcugggac                                                   20


<210>  15791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15791
ugaguagcug ggacuacagg                                                   20


<210>  15792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15792
ggaggcugag gcaggagaau                                                   20


<210>  15793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15793
acuaauaaaa aauacaaaaa                                                   20


<210>  15794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15794
ugaccucgug auccguccac                                                   20


<210>  15795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15795
ugauccgucc accucagccu                                                   20


<210>  15796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15796
gccucucaaa gugcugggau                                                   20


<210>  15797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15797
caaagugcug ggauuacagg                                                   20


<210>  15798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15798
aagugcuggg auuacaggca                                                   20


<210>  15799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15799
ugccuguaau cccagcacuu                                                   20


<210>  15800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15800
caccuguaau cccagcacuu                                                   20


<210>  15801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15801
caaagugcug ggauuacagg                                                   20


<210>  15802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15802
gccucccaaa gugcugggau                                                   20


<210>  15803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15803
ugauccgccc accucagccu                                                   20


<210>  15804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15804
cgaccucgug auccgcccac                                                   20


<210>  15805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15805
acuaaaaaua ccacaaaaaa                                                   20


<210>  15806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15806
cgccagucgu cccagcuacu                                                   20


<210>  15807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15807
caaguagcug ggacgacugg                                                   20


<210>  15808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15808
gccucccaag uagcugggac                                                   20


<210>  15809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15809
ugccucagcc ucccaaguag                                                   20


<210>  15810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15810
accugccaga uucaagcaau                                                   20


<210>  15811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15811
cugcaaccuc caccugccag                                                   20


<210>  15812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15812
gcucacugca accuccaccu                                                   20


<210>  15813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15813
agccugggcg auagagcgag                                                   20


<210>  15814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15814
aucgcccagg cuagagugca                                                   20


<210>  15815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15815
cucuaucgcc caggcuagag                                                   20


<210>  15816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15816
gucucaaaaa aaaaaaaaaa                                                   20


<210>  15817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15817
aaaaaaaaaa aaaaagaaga                                                   20


<210>  15818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15818
cguaucauug uuuuguggug                                                   20


<210>  15819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15819
ccacaaaaca augauacgug                                                   20


<210>  15820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15820
uucagugauu uucuugcaua                                                   20


<210>  15821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15821
ugaacucauu ccuccugucu                                                   20


<210>  15822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15822
uuccuccugu cuauaaauga                                                   20


<210>  15823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15823
ugucuauaaa ugaaauuuug                                                   20


<210>  15824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15824
aaaaaaaccu ugaauguguu                                                   20


<210>  15825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15825
aucucaaaaa aaaccuugaa                                                   20


<210>  15826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15826
agccugggug aagaagacuc                                                   20


<210>  15827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15827
ucucacugca accuccgccu                                                   20


<210>  15828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15828
cugcaaccuc cgccucccag                                                   20


<210>  15829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15829
gccucccagg uucaagcaau                                                   20


<210>  15830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15830
cagguucaag caauucuccu                                                   20


<210>  15831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15831
ugccucagcc uccugaguag                                                   20


<210>  15832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15832
gccuccugag uagcugggau                                                   20


<210>  15833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15833
ugaguagcug ggauuacagg                                                   20


<210>  15834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15834
ggaggcugag gcaggagaau                                                   20


<210>  15835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15835
acuucuacua aaaauacaaa                                                   20


<210>  15836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15836
aacuccugac cucaagugau                                                   20


<210>  15837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15837
ugaccucaag ugauccgccu                                                   20


<210>  15838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15838
agugauccgc cugccuuggc                                                   20


<210>  15839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15839
caccuguaau cccagcacuu                                                   20


<210>  15840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15840
agcguuuuaa aagaugcucu                                                   20


<210>  15841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15841
uuucuaagga uugacuguag                                                   20


<210>  15842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15842
uguacuacag ucaauccuua                                                   20


<210>  15843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15843
gccuuuacaa guguaaaauu                                                   20


<210>  15844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15844
aagucaaaag ucuucaaacu                                                   20


<210>  15845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15845
ugaaguuguu ggccacuaag                                                   20


<210>  15846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15846
gagagguucu ggaauuggcc                                                   20


<210>  15847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15847
gagccuaaga uuccuuagug                                                   20


<210>  15848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15848
cugagccuaa gauuccuuag                                                   20


<210>  15849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15849
uaugauucuc uaacugauuu                                                   20


<210>  15850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15850
aacugauuuc ucacaaagca                                                   20


<210>  15851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15851
caaagcaaac aagcaaucau                                                   20


<210>  15852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15852
ucuuauuuug uuauuuaaaa                                                   20


<210>  15853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15853
acuuauguuu guuagucaau                                                   20


<210>  15854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15854
uuacuucuag uuaaucaaaa                                                   20


<210>  15855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15855
gaccuuuuga uuaacuagaa                                                   20


<210>  15856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15856
uuaaaacuug gcaaguuauu                                                   20


<210>  15857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15857
gguccuguua caacaaguaa                                                   20


<210>  15858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15858
ucacugggga guuucuauca                                                   20


<210>  15859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15859
ccagugauga ggauuuacuu                                                   20


<210>  15860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15860
aacugcauga uguccugaaa                                                   20


<210>  15861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15861
gcaucuuuua aaaauauaua                                                   20


<210>  15862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15862
aagggcuuau acauccuaca                                                   20


<210>  15863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15863
uaucucaaag ggcuuauaca                                                   20


<210>  15864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15864
cagcuaagau ugauuacagu                                                   20


<210>  15865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15865
gucacuguaa ucaaucuuag                                                   20


<210>  15866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15866
accagggcca cuucccccua                                                   20


<210>  15867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15867
agacuccacc agggccacuu                                                   20


<210>  15868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15868
cgugaggcuc acacaaaaau                                                   20


<210>  15869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15869
cgggagggaa ggaagccugu                                                   20


<210>  15870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15870
cacaaaaaua cagcaacaug                                                   20


<210>  15871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15871
gccuaacaug agccacaauu                                                   20


<210>  15872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15872
uguuaggcag aggguaccug                                                   20


<210>  15873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15873
cagaagaaaa gcagguguuc                                                   20


<210>  15874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15874
ccaugcccag acuauuugaa                                                   20


<210>  15875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15875
uggggguauc uggugaacag                                                   20


<210>  15876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15876
agccaauuag ugcagaaaaa                                                   20


<210>  15877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15877
uaguucucua guuucaguag                                                   20


<210>  15878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15878
aguuucagua guuucauuua                                                   20


<210>  15879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15879
ucuauuagaa gcauccuugu                                                   20


<210>  15880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15880
gucuaaaaaa gaaaaaaaaa                                                   20


<210>  15881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15881
guccccaggu uggagugcag                                                   20


<210>  15882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15882
aaccugggga cagagcaaga                                                   20


<210>  15883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15883
cugcagucuc agggcucaag                                                   20


<210>  15884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15884
gggcucaagu gauccuccca                                                   20


<210>  15885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15885
agugauccuc ccaccucagc                                                   20


<210>  15886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15886
caccucagcu ccugaguacc                                                   20


<210>  15887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15887
gcuccugagu accugggacu                                                   20


<210>  15888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15888
ugaguaccug ggacuaccgg                                                   20


<210>  15889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15889
ggagcugagg ugggaggauc                                                   20


<210>  15890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15890
acaaaaaaug uaaaaauuag                                                   20


<210>  15891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15891
cuaaguugcc ugggcugguc                                                   20


<210>  15892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15892
agcuccuggc uuaaguaauc                                                   20


<210>  15893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15893
uggcuuaagu aauccucccu                                                   20


<210>  15894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15894
cuccuuggcc ucccaaagug                                                   20


<210>  15895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15895
uuggccuccc aaagugcugg                                                   20


<210>  15896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15896
caaagugcug ggauuacagg                                                   20


<210>  15897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15897
caccuguaau cccagcacuu                                                   20


<210>  15898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15898
uaaauaccau uaagcuacaa                                                   20


<210>  15899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15899
cuaaaucaau cuacaaguag                                                   20


<210>  15900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15900
gauguuaagu cacccugucc                                                   20


<210>  15901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15901
gaagcacaug aaauuuaaag                                                   20


<210>  15902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15902
ugcacauuuc uugauaaaug                                                   20


<210>  15903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15903
gguauuccuc uguuuuuguu                                                   20


<210>  15904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15904
guuuuuguua cuaauaguua                                                   20


<210>  15905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15905
aaccuuguaa aauaugaaga                                                   20


<210>  15906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15906
uuaagcugca ugguucucau                                                   20


<210>  15907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15907
ugucagcucc caaagcagaa                                                   20


<210>  15908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15908
caaagcagaa gacggcaugu                                                   20


<210>  15909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15909
acggcauuuu ucaacaugcc                                                   20


<210>  15910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15910
uaucaucuug aauuucaggg                                                   20


<210>  15911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15911
uagugcuugc uaucuguuua                                                   20


<210>  15912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15912
agcauguucu gcuguaauuc                                                   20


<210>  15913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15913
cuggcaucuu ggacuccugu                                                   20


<210>  15914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15914
uguuuccuuu gcucugucau                                                   20


<210>  15915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15915
gucauccccg cggucagcuc                                                   20


<210>  15916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15916
ugcugcgcag cuucucagcu                                                   20


<210>  15917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15917
gcugaagugc guuuggagug                                                   20


<210>  15918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15918
aaacgcacuu cagcugagaa                                                   20


<210>  15919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15919
aagauccagc aagacacgcc                                                   20


<210>  15920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15920
gguuuccuug guuccuucug                                                   20


<210>  15921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15921
gcagaaggaa ccaaggaaac                                                   20


<210>  15922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15922
gcgucuccac uccccauuuc                                                   20


<210>  15923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15923
acuccccauu ucuugugugg                                                   20


<210>  15924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15924
ccauuucuug uguggcccuu                                                   20


<210>  15925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15925
ucugauuccu uuugucuucc                                                   20


<210>  15926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15926
gauuccuuuu gucuucccug                                                   20


<210>  15927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15927
aaaccaaagc aagaaaccag                                                   20


<210>  15928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15928
acagaacuuu ugcagcucuu                                                   20


<210>  15929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15929
ucugaagacc uggaagcuuu                                                   20


<210>  15930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15930
ucucaugacc ucuuuucccu                                                   20


<210>  15931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15931
ugaccucuuu ucccuucuuu                                                   20


<210>  15932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15932
uuucccuucu uugagagcua                                                   20


<210>  15933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15933
aagaagggaa aagaggucau                                                   20


<210>  15934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15934
caaagaaggg aaaagagguc                                                   20


<210>  15935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15935
uuccagaauu ccaugccuuc                                                   20


<210>  15936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15936
cacuuaccug uuguccagga                                                   20


<210>  15937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15937
uggacaacag guaaguggga                                                   20


<210>  15938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15938
ccuggacaac agguaagugg                                                   20


<210>  15939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15939
aauaugcaca gcaaucugac                                                   20


<210>  15940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15940
uccaauaugc acagcaaucu                                                   20


<210>  15941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15941
ucaucucaca ugacaucacc                                                   20


<210>  15942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15942
caugacauca ccacaucacc                                                   20


<210>  15943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15943
uuccuuggac ccucaguggu                                                   20


<210>  15944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15944
guggugucac ugcuggauuu                                                   20


<210>  15945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15945
cauuuucagu uucugugucu                                                   20


<210>  15946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15946
ugccugcuuc ugacuucgcc                                                   20


<210>  15947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15947
gggcgaaguc agaagcaggc                                                   20


<210>  15948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15948
uucacaaggg uucuuagauu                                                   20


<210>  15949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15949
gugaacauaa aucuaagaac                                                   20


<210>  15950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15950
gaaaagaagg ugcucaguga                                                   20


<210>  15951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15951
ccuuaccuuu cuuguuaugc                                                   20


<210>  15952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15952
gagucuguaa aauagaauug                                                   20


<210>  15953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15953
gagaaugggu caggaccaaa                                                   20


<210>  15954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15954
cagggauccu aguguauaag                                                   20


<210>  15955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15955
uuaugaaaga aaguuaggaa                                                   20


<210>  15956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15956
uucaaaggcu uucagguuac                                                   20


<210>  15957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15957
ccuugcaggg ugugucugcg                                                   20


<210>  15958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15958
acugugcggc gccguacacu                                                   20


<210>  15959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15959
uaauguacaa ccaaagacac                                                   20


<210>  15960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15960
ccuucaccuu cccaagguca                                                   20


<210>  15961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15961
uucaccuucc caaggucacg                                                   20


<210>  15962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15962
aaacuuuucc gugcuguucu                                                   20


<210>  15963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15963
gcucagccuu ggauguucuu                                                   20


<210>  15964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15964
gccuuggaug uucuuucuca                                                   20


<210>  15965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15965
gauacuagag cuggccacac                                                   20


<210>  15966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15966
aguaucugag aaagaacauc                                                   20


<210>  15967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15967
uuggguugug gcuggcacac                                                   20


<210>  15968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15968
gcccagaaga cgcacaucaa                                                   20


<210>  15969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15969
auccuagaug aacucagccc                                                   20


<210>  15970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15970
agggugccuc cgggagacuc                                                   20


<210>  15971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15971
gggagacucc ucccugcccc                                                   20


<210>  15972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15972
cggaggcacc cuggagaacc                                                   20


<210>  15973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15973
ucccugcccc acgugcuugc                                                   20


<210>  15974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15974
cugccccacg ugcuugcguc                                                   20


<210>  15975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15975
gccuuagcca ugaaguuuag                                                   20


<210>  15976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15976
acaaacacau uuugaaaccc                                                   20


<210>  15977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15977
cgccccgccc ccuuacccgu                                                   20


<210>  15978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15978
uuugugccug aggaaguaac                                                   20


<210>  15979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15979
ggcacaaaag agcaagucac                                                   20


<210>  15980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15980
guuacuuccu caggcacaaa                                                   20


<210>  15981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15981
gacacagaua gucucugacu                                                   20


<210>  15982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15982
gacuuaucuc acagaaaguc                                                   20


<210>  15983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15983
cagaaaguca gcggcagagc                                                   20


<210>  15984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15984
gccgcugacu uucugugaga                                                   20


<210>  15985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15985
ggcucugccg cugacuuucu                                                   20


<210>  15986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15986
uagauuuucu uuuucuuuuu                                                   20


<210>  15987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15987
uaauguuauc ccucccccag                                                   20


<210>  15988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15988
cccagucccc ucacucccca                                                   20


<210>  15989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15989
cuccccaugg gccccggugu                                                   20


<210>  15990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15990
ccaugggccc cgguguguga                                                   20


<210>  15991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15991
ucccugugcc cauguguucu                                                   20


<210>  15992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15992
cugugcccau guguucucau                                                   20


<210>  15993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15993
uuguucaauu uccacuugug                                                   20


<210>  15994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15994
caaguggaaa uugaacaaug                                                   20


<210>  15995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15995
cucacaagug gaaauugaac                                                   20


<210>  15996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15996
gcaaacuauc acaagaucag                                                   20


<210>  15997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15997
uccuuuuuua uggcuguaua                                                   20


<210>  15998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15998
aaggucuaga acuagaaaua                                                   20


<210>  15999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  15999
caccaacagu guaaaagugu                                                   20


<210>  16000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16000
ccagcaucug uuguuucgug                                                   20


<210>  16001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16001
agcaucuguu guuucgugac                                                   20


<210>  16002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16002
cgccaguuag gauggcgauc                                                   20


<210>  16003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16003
uugugauuuu gaucugcauu                                                   20


<210>  16004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16004
aaugaccagu ggugaugagc                                                   20


<210>  16005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16005
ucaccacugg ucauuagaga                                                   20


<210>  16006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16006
gaugauaguu ucuuuugcua                                                   20


<210>  16007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16007
uuaguuuaau uagaucccgu                                                   20


<210>  16008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16008
agauggauca aagacuuaaa                                                   20


<210>  16009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16009
gaaauaccac cacacaucua                                                   20


<210>  16010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16010
guucuguucc auuggucuau                                                   20


<210>  16011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16011
agcuuuguuc uucuagccca                                                   20


<210>  16012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16012
uuuuugguuc cauaugaagu                                                   20


<210>  16013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16013
cuuauuuccu ugagcagugg                                                   20


<210>  16014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16014
uauuuccuug agcagugguu                                                   20


<210>  16015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16015
aggaaauaag agaggacaca                                                   20


<210>  16016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16016
uugaagaggu ccuucacauc                                                   20


<210>  16017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16017
ucaaggagaa cuacaaacca                                                   20


<210>  16018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16018
cauucacaaa ugcuacuaag                                                   20


<210>  16019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16019
ugauuuggcu cucuguuugu                                                   20


<210>  16020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16020
cuguuugucu guuauuggug                                                   20


<210>  16021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16021
guuugucugu uauuggugua                                                   20


<210>  16022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16022
ggauacaaaa ucaaugugca                                                   20


<210>  16023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16023
uuaagcugau uagcaacuuc                                                   20


<210>  16024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16024
aaaucuccuu aagcugauua                                                   20


<210>  16025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16025
cuuccuauuu gaauacccuu                                                   20


<210>  16026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16026
uccuauuuga auacccuuua                                                   20


<210>  16027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16027
ugccugauug cgcuggccag                                                   20


<210>  16028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16028
uauucaacau aguauuggaa                                                   20


<210>  16029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16029
ccacuccuau ucaacauagu                                                   20


<210>  16030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16030
caccacuccu auucaacaua                                                   20


<210>  16031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16031
cucaccacuc cuauucaaca                                                   20


<210>  16032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16032
uacuauguug agauacguuc                                                   20


<210>  16033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16033
acauaguaag agcuauuuau                                                   20


<210>  16034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16034
auaaacuagg uaucgaugga                                                   20


<210>  16035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16035
caauaaacua gguaucgaug                                                   20


<210>  16036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16036
acagaugcag aaaaggccuu                                                   20


<210>  16037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16037
auaaaauacu ggcaaacuga                                                   20


<210>  16038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16038
uuuuuuguug ugucucugcc                                                   20


<210>  16039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16039
gccaggcuuu gguaucagga                                                   20


<210>  16040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16040
uaaaaugagu uagggaggau                                                   20


<210>  16041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16041
uuuuaugagg ccagcaucau                                                   20


<210>  16042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16042
cuaacucauu uuaugaggcc                                                   20


<210>  16043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16043
cuuuuucuau ugauuggaau                                                   20


<210>  16044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16044
uuuucuauug auuggaauag                                                   20


<210>  16045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16045
ucuuuguacc ucugguagaa                                                   20


<210>  16046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16046
uuguaccucu gguagaauuc                                                   20


<210>  16047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16047
gguagaauuc ggcugugaau                                                   20


<210>  16048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16048
aguuuagaac cuguuaucag                                                   20


<210>  16049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16049
gaauagacug auaacagguu                                                   20


<210>  16050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16050
caagacuaaa ccagaaaaaa                                                   20


<210>  16051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16051
acccaaauaa acuagaaaau                                                   20


<210>  16052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16052
gaugguaguu uguauuucug                                                   20


<210>  16053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16053
auaaaaacga uaaaggggau                                                   20


<210>  16054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16054
cuuuucuucu uuauuagucu                                                   20


<210>  16055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16055
uuucuucuuu auuagucuug                                                   20


<210>  16056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16056
aaaaaaaauc aaugaaucca                                                   20


<210>  16057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16057
aucuccuuca guucugcucu                                                   20


<210>  16058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16058
uucaguucug cucugaucuu                                                   20


<210>  16059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16059
gaucuuaguu auuuuuuguc                                                   20


<210>  16060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16060
ugcuuuucua guucuuuuaa                                                   20


<210>  16061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16061
ugugggcauu uagugcuaua                                                   20


<210>  16062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16062
acacacugcu uuaaaugugu                                                   20


<210>  16063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16063
gggacacauu uaaagcagug                                                   20


<210>  16064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16064
uugguuucca agaaaauuuu                                                   20


<210>  16065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16065
ugaaugacua cuggguaaau                                                   20


<210>  16066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16066
aaaccacaca acuacaugga                                                   20


<210>  16067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16067
cucaaaacca cacaacuaca                                                   20


<210>  16068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16068
auccugaguu cuaauuugau                                                   20


<210>  16069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16069
ggauugagaa ucucacucaa                                                   20


<210>  16070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16070
gcaaauguaa aagaacagaa                                                   20


<210>  16071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16071
ucagcaaaug uaaaagaaca                                                   20


<210>  16072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16072
gcaccacauu gcacuuauuc                                                   20


<210>  16073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16073
gcaccccaaa ucaacagaac                                                   20


<210>  16074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16074
gcacuggacc aagcggaccu                                                   20


<210>  16075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16075
uugaucugcc uaauauugac                                                   20


<210>  16076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16076
cacuauuacc gggugggagu                                                   20


<210>  16077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16077
cacccgguaa uagugggaga                                                   20


<210>  16078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16078
uuguaggucu cuaagaacuu                                                   20


<210>  16079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16079
aagaacuugc uucaugaauc                                                   20


<210>  16080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16080
uguauugggg gcguguauau                                                   20


<210>  16081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16081
ucuuguugaa uugaucccuu                                                   20


<210>  16082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16082
uuugaacuuu guugauuuaa                                                   20


<210>  16083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16083
gauaaaacag acuuuaaauc                                                   20


<210>  16084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16084
aucccuuuau uuugagccaa                                                   20


<210>  16085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16085
aaauaaaggg auggaggaag                                                   20


<210>  16086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16086
uuggcucaaa auaaagggau                                                   20


<210>  16087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16087
caugcaaaga cacucauugg                                                   20


<210>  16088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16088
ugaauacagc acaccaaugg                                                   20


<210>  16089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16089
uuauccaauu ugccagucug                                                   20


<210>  16090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16090
ugaaggaagc acuaaacaug                                                   20


<210>  16091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16091
uguaaggcag gccugguggu                                                   20


<210>  16092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16092
gcauuugcuu gucuguaaag                                                   20


<210>  16093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16093
uucacuuaug aagcuuaguu                                                   20


<210>  16094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16094
cacucuuuuc uggcuuguag                                                   20


<210>  16095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16095
uuucuggcuu guaggauuuc                                                   20


<210>  16096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16096
gcagaaaucc uacaagccag                                                   20


<210>  16097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16097
cugcagaaau ccuacaagcc                                                   20


<210>  16098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16098
cuggcugccc uuuccuucau                                                   20


<210>  16099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16099
ggcugcccuu uccuucauuu                                                   20


<210>  16100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16100
ucucgaggag uaucuuugug                                                   20


<210>  16101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16101
aggaguaucu uugugguguu                                                   20


<210>  16102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16102
agaagagcaa ccccaagaca                                                   20


<210>  16103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16103
ucgagaagag caaccccaag                                                   20


<210>  16104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16104
guauuuccug aauuugaaug                                                   20


<210>  16105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16105
uggauaauau ccugaagagu                                                   20


<210>  16106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16106
ucaggauauu auccaggaga                                                   20


<210>  16107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16107
ccaucacuuu cagguacacc                                                   20


<210>  16108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16108
aagaaauaug ggacuaugug                                                   20


<210>  16109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16109
uuuuucucua aucuugucuu                                                   20


<210>  16110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16110
aaucuugucu ucucgcuuua                                                   20


<210>  16111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16111
cuuuauuuca uuaauuugau                                                   20


<210>  16112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16112
uucugugguu uuuagcucca                                                   20


<210>  16113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16113
aucaggucau uuaagcucuu                                                   20


<210>  16114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16114
ucucuacacu gguuauucua                                                   20


<210>  16115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16115
acacugguua uucuagccau                                                   20


<210>  16116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16116
uuuagcucgg agaaguuugu                                                   20


<210>  16117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16117
gagaaguuug uuauuaccga                                                   20


<210>  16118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16118
gagcuaaagg agcauguucu                                                   20


<210>  16119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16119
uucuccaucc aguuuuguuc                                                   20


<210>  16120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16120
auccaguuuu guucccuugc                                                   20


<210>  16121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16121
ccagcaaggg aacaaaacug                                                   20


<210>  16122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16122
ucaccagcaa gggaacaaaa                                                   20


<210>  16123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16123
aaaggaucac aacuccucac                                                   20


<210>  16124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16124
uccaaaggau cacaacuccu                                                   20


<210>  16125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16125
ucuccuccaa aggaucacaa                                                   20


<210>  16126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16126
ccaucauugu gguuuuaucu                                                   20


<210>  16127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16127
gcugcagguc uguuggaguu                                                   20


<210>  16128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16128
aacagaccug cagcugaggg                                                   20


<210>  16129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16129
agcaaacucc aacagaccug                                                   20


<210>  16130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16130
aggcccuguu ugccugggca                                                   20


<210>  16131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16131
gcuggugaug cccaggcaaa                                                   20


<210>  16132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16132
ggaaacaucg ucccagagca                                                   20


<210>  16133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16133
gggacgaugu uuccagagga                                                   20


<210>  16134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16134
uacaggcaga caccuucgug                                                   20


<210>  16135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16135
caguaggggc caacaaacac                                                   20


<210>  16136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16136
cagucaggcu acaugggggu                                                   20


<210>  16137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16137
aguggguccc ugacccccau                                                   20


<210>  16138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16138
gauaaugaac agacugccuc                                                   20


<210>  16139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16139
cgguacggca uucaagcucc                                                   20


<210>  16140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16140
cuucagagcu gucaggcacg                                                   20


<210>  16141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16141
ucagagcugu caggcacgua                                                   20


<210>  16142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16142
gaagagagca gugguucucc                                                   20


<210>  16143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16143
agauuuaaac auacgugccu                                                   20


<210>  16144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16144
gggggaaggg cacaucugaa                                                   20


<210>  16145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16145
agauuccacc ucugggggaa                                                   20


<210>  16146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16146
cuagauucca ccucuggggg                                                   20


<210>  16147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16147
gcaaggccua cugccucucu                                                   20


<210>  16148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16148
gcccaguucg agcuucccug                                                   20


<210>  16149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16149
aacugggcag agcccacugc                                                   20


<210>  16150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16150
caguguaaac aaagcagcag                                                   20


<210>  16151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16151
agccucagca gugguggaca                                                   20


<210>  16152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16152
gcaguggugg acaccccucc                                                   20


<210>  16153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16153
cccagccaag cuccugcauc                                                   20


<210>  16154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16154
ugcaucccag gucgauuuca                                                   20


<210>  16155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16155
gaaaucgacc ugggaugcag                                                   20


<210>  16156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16156
cugcuagcgc agcacucuga                                                   20


<210>  16157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16157
gcggguccca cgcccauggg                                                   20


<210>  16158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16158
ugugccuggc ucagcggguc                                                   20


<210>  16159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16159
ccugugccug gcucagcggg                                                   20


<210>  16160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16160
uggucugcug guugugaaga                                                   20


<210>  16161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16161
ugcccaaaua cugcacuuuu                                                   20


<210>  16162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16162
uucagguaca gucacucaug                                                   20


<210>  16163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16163
uggcuuccuu uggcuuggaa                                                   20


<210>  16164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16164
ccugggaagc acaagggguc                                                   20


<210>  16165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16165
gugggcugca cccacugucc                                                   20


<210>  16166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16166
cugggacuug cuggacagug                                                   20


<210>  16167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16167
guuggaaaug cagaaaucac                                                   20


<210>  16168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16168
cugggagcug uagacuggag                                                   20


<210>  16169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16169
cagugagauc gacacagaag                                                   20


<210>  16170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16170
agucuacagc ucccagugag                                                   20


<210>  16171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16171
aaaaacaagg gaugcuucca                                                   20


<210>  16172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16172
accucaaaaa acaagggaug                                                   20


<210>  16173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16173
gucgcccagg cugacgugca                                                   20


<210>  16174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16174
gcccacugca accuuugccu                                                   20


<210>  16175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16175
ugguuucaag cgauucuccu                                                   20


<210>  16176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16176
uaccucagcc uccggaguag                                                   20


<210>  16177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16177
gccuccggag uagcugggau                                                   20


<210>  16178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16178
ggaguagcug ggauuacagg                                                   20


<210>  16179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16179
ggaggcugag guaggagaau                                                   20


<210>  16180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16180
acuaaaaaua caaaaaauua                                                   20


<210>  16181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16181
aacuccugac cuugugaucc                                                   20


<210>  16182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16182
ugaccuugug auccacccac                                                   20


<210>  16183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16183
gccuccuaga gugcugggau                                                   20


<210>  16184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16184
uagagugcug ggaucacagg                                                   20


<210>  16185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16185
aggaggcuga ggugggugga                                                   20


<210>  16186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16186
cucucuuugc ccuaaaccac                                                   20


<210>  16187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16187
cuuugcccua aaccacugug                                                   20


<210>  16188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16188
uugcccuaaa ccacugugcu                                                   20


<210>  16189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16189
auguauaaca cauuuuagca                                                   20


<210>  16190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16190
cguucaaauu uaaaacauau                                                   20


<210>  16191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16191
ucucugaaaa uuuuuacauu                                                   20


<210>  16192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16192
gaaaauuuuu acauuuggca                                                   20


<210>  16193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16193
ggccuguguc uuuacaguua                                                   20


<210>  16194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16194
ccucuccuuu uuuguuuuuc                                                   20


<210>  16195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16195
ccuuuuuugu uuuucuaagu                                                   20


<210>  16196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16196
uuuuuuguuu uucuaaguuc                                                   20


<210>  16197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16197
gucuugaaac agcaaaaaag                                                   20


<210>  16198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16198
cauauccuuu uguuuguacu                                                   20


<210>  16199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16199
ccugcuuaau uguugaguuu                                                   20


<210>  16200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16200
acaauuaagc aggugaggcu                                                   20


<210>  16201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16201
aaaagaccac ggauaaaaac                                                   20


<210>  16202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16202
aaacagucag gggccaagug                                                   20


<210>  16203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16203
cucacugacu cacagcaugg                                                   20


<210>  16204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16204
cugacucaca gcauggcaag                                                   20


<210>  16205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16205
cagcauggca agguuucaga                                                   20


<210>  16206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16206
uucugccaca cagcaguucu                                                   20


<210>  16207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16207
gaacugcugu guggcagaaa                                                   20


<210>  16208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16208
agccuggccu gacaaucuaa                                                   20


<210>  16209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16209
auaguuugua uaucucaagc                                                   20


<210>  16210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16210
gaugccuuca ccuaagcaag                                                   20


<210>  16211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16211
gcaugugugc ggggcugggu                                                   20


<210>  16212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16212
acacccagcc ccgcacacau                                                   20


<210>  16213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16213
gaccucaaca cccagccccg                                                   20


<210>  16214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16214
agcuacacuu gugcucagac                                                   20


<210>  16215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16215
ccagcuacac uugugcucag                                                   20


<210>  16216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16216
ccucuccagc uacacuugug                                                   20


<210>  16217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16217
uacccgucgc cacaucaagc                                                   20


<210>  16218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16218
cagaagucug aagaaaaccu                                                   20


<210>  16219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16219
gugccuuuaa auccuggaac                                                   20


<210>  16220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16220
uuuuuauaca uaauugaaau                                                   20


<210>  16221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16221
uuacuguucc auuuuauaug                                                   20


<210>  16222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16222
acaaaaagaa aaacaaaaau                                                   20


<210>  16223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16223
gggcugaggu gggaggauug                                                   20


<210>  16224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16224
gccccgagua gcugggacca                                                   20


<210>  16225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16225
caccucagcc ccgaguagcu                                                   20


<210>  16226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16226
agcaauccuc ccaccucagc                                                   20


<210>  16227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16227
caaggcucaa gcaauccucc                                                   20


<210>  16228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16228
accucccaag gcucaagcaa                                                   20


<210>  16229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16229
uugcagccuc aaccucccaa                                                   20


<210>  16230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16230
agcaugggug acagacuuua                                                   20


<210>  16231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16231
auaaacccag gcacaagaaa                                                   20


<210>  16232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16232
aaaaaaaaaa aaagaaagaa                                                   20


<210>  16233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16233
cucugucgcc ugcguuggag                                                   20


<210>  16234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16234
gucgccugcg uuggagugca                                                   20


<210>  16235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16235
aacgcaggcg acagagcgag                                                   20


<210>  16236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16236
cugcaagcuc ugccuccugg                                                   20


<210>  16237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16237
gccuccuggg uucacgccau                                                   20


<210>  16238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16238
uggguucacg ccauucuccu                                                   20


<210>  16239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16239
ugccucagcc uccugaguag                                                   20


<210>  16240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16240
gccuccugag uagcugggac                                                   20


<210>  16241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16241
ugaguagcug ggacuacagg                                                   20


<210>  16242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16242
ggaggcugag gcaggagaau                                                   20


<210>  16243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16243
acuaaaaaua caaaaaauua                                                   20


<210>  16244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16244
ucucuacuaa aaauacaaaa                                                   20


<210>  16245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16245
aucuccugac cucgugaucu                                                   20


<210>  16246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16246
ugaccucgug aucugcccgc                                                   20


<210>  16247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16247
ugaucugccc gccugggccu                                                   20


<210>  16248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16248
caaagugcug ggauuacagg                                                   20


<210>  16249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16249
cgccuguaau cccagcacuu                                                   20


<210>  16250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16250
cuccuuuuuu cccucucuua                                                   20


<210>  16251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16251
uuuuuucccu cucuuaaagg                                                   20


<210>  16252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16252
cuuaaagggg cugugauuuc                                                   20


<210>  16253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16253
uaaaggggcu gugauuuccu                                                   20


<210>  16254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16254
uuucaguguu ugauuguuuu                                                   20


<210>  16255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16255
gaucuuuucu ucuacagugu                                                   20


<210>  16256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16256
guuguuaauc uguuaaucug                                                   20


<210>  16257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16257
cucuguugcc caggcuggag                                                   20


<210>  16258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16258
guugcccagg cuggaguuua                                                   20


<210>  16259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16259
agccugggca acagagugag                                                   20


<210>  16260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16260
cugcaaccuc caccucccag                                                   20


<210>  16261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16261
accucccagg cucaagcaau                                                   20


<210>  16262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16262
caggcucaag caauucuucu                                                   20


<210>  16263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16263
agcaauucuu cugccucagc                                                   20


<210>  16264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16264
gccucccgag uagcugggac                                                   20


<210>  16265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16265
cgaguagcug ggacuauagg                                                   20


<210>  16266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16266
ggaggcugag gcagaagaau                                                   20


<210>  16267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16267
aauaaaaaua cacaaauuag                                                   20


<210>  16268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16268
ugaccucagg ugauucaucc                                                   20


<210>  16269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16269
ggugauucau ccgccucggu                                                   20


<210>  16270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16270
gucucccaaa guguugggau                                                   20


<210>  16271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16271
caaaguguug ggauuauagg                                                   20


<210>  16272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16272
ugccuauaau cccaacacuu                                                   20


<210>  16273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16273
agaaguuuga uuuaggucuu                                                   20


<210>  16274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16274
cuguguuucu guuuagcuuu                                                   20


<210>  16275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16275
gcuaguucua agaucuucua                                                   20


<210>  16276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16276
uugguugauu gauacuccuc                                                   20


<210>  16277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16277
ucguuuuggg uuguauuuuc                                                   20


<210>  16278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16278
uuuuggguug uauuuuccug                                                   20


<210>  16279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16279
uuguauggcu gccaauuuuu                                                   20


<210>  16280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16280
agaagaucua ugggaacaca                                                   20


<210>  16281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16281
gaacaaagcu caagaagauc                                                   20


<210>  16282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16282
acuaaccuca gaacaaagcu                                                   20


<210>  16283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16283
uuugggucuu gcuuuauaau                                                   20


<210>  16284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16284
aacccaucug acaaauuaua                                                   20


<210>  16285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16285
uuaggaauaa uuagguacca                                                   20


<210>  16286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16286
uaagcauggu accuaauuau                                                   20


<210>  16287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16287
ggauggucuu gccuccuaag                                                   20


<210>  16288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16288
accuaaugaa ccagaaaguu                                                   20


<210>  16289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16289
gcaggcggac uggaaaaccc                                                   20


<210>  16290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16290
cacagggcua gaaagucacu                                                   20


<210>  16291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16291
gcgcucacac agggcuagaa                                                   20


<210>  16292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16292
gcuccuucua auccuuucca                                                   20


<210>  16293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16293
uucuaauccu uuccaaugcu                                                   20


<210>  16294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16294
gggaguuuuc ucacacacau                                                   20


<210>  16295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16295
cugaggccag ggaaagaagc                                                   20


<210>  16296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16296
cacacauauc ucugcugagu                                                   20


<210>  16297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16297
gcugaguacu cgagagggac                                                   20


<210>  16298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16298
gcagagauau gugugugaga                                                   20


<210>  16299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16299
agagggaccu uccccagauc                                                   20


<210>  16300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16300
aguacucagc agagauaugu                                                   20


<210>  16301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16301
cgaguacuca gcagagauau                                                   20


<210>  16302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16302
agagcucucu cugucuuguu                                                   20


<210>  16303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16303
ggagaucugg ggaagguccc                                                   20


<210>  16304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16304
cucugucuug uuuucucuuc                                                   20


<210>  16305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16305
cugucuuguu uucucuucuc                                                   20


<210>  16306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16306
gucuuguuuu cucuucucug                                                   20


<210>  16307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16307
ucucuggugc ucugucuuau                                                   20


<210>  16308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16308
ggugcucugu cuuaugaacu                                                   20


<210>  16309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16309
gucuuaugaa cuguggcugu                                                   20


<210>  16310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16310
uuagauucuc agcaccucuu                                                   20


<210>  16311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16311
gcaccucuuc aauucagagg                                                   20


<210>  16312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16312
ucaauucaga ggguugccug                                                   20


<210>  16313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16313
gaauugaaga ggugcugaga                                                   20


<210>  16314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16314
uccuugugcc acagccuagg                                                   20


<210>  16315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16315
uugugccaca gccuaggaac                                                   20


<210>  16316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16316
cucaaagcag cgaguugggg                                                   20


<210>  16317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16317
caaagcagcg aguuggggca                                                   20


<210>  16318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16318
aagcagcgag uuggggcagc                                                   20


<210>  16319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16319
cugcuuugag agaguuccua                                                   20


<210>  16320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16320
cgucucccag ggaucacugu                                                   20


<210>  16321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16321
ucucccaggg aucacugucc                                                   20


<210>  16322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16322
cagggaucac uguccuucau                                                   20


<210>  16323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16323
uguccagugu cuugaggacu                                                   20


<210>  16324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16324
agacacugga caugagcaau                                                   20


<210>  16325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16325
ggguuuuguc uguuuuguuu                                                   20


<210>  16326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16326
ggcaggaggg uaaacccagu                                                   20


<210>  16327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16327
ugccugagac aaccaaagca                                                   20


<210>  16328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16328
cccucauugu gcucaguagu                                                   20


<210>  16329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16329
uugugcucag uaguggaagu                                                   20


<210>  16330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16330
guaguggaag ucucacucua                                                   20


<210>  16331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16331
cucuauuaca uuagauauua                                                   20


<210>  16332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16332
auuacauuag auauuaguau                                                   20


<210>  16333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16333
gcuacaaaua cuaauaucua                                                   20


<210>  16334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16334
ccaaguacca gggaaccagg                                                   20


<210>  16335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16335
ugaaaggcca gaaacagcau                                                   20


<210>  16336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16336
ccuuuuccag ggcuucaguu                                                   20


<210>  16337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16337
cagcagauac ccaauacaug                                                   20


<210>  16338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16338
aaguauauuc uaaguguuua                                                   20


<210>  16339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16339
agggccacac auuuuuaaaa                                                   20


<210>  16340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16340
acuaauaagc aauagauucu                                                   20


<210>  16341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16341
acuuguuuaa caaaauaucc                                                   20


<210>  16342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16342
ccacuuguuu aacaaaauau                                                   20


<210>  16343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16343
cuccacuugu uuaacaaaau                                                   20


<210>  16344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16344
cucuccacuu guuuaacaaa                                                   20


<210>  16345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16345
uugaguuagc aucuucuucu                                                   20


<210>  16346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16346
aagagcgcca ccauucugaa                                                   20


<210>  16347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16347
aaaaaaaaaa aaaaagaauc                                                   20


<210>  16348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16348
uguugcccag guaacaacuc                                                   20


<210>  16349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16349
agugcaaugg cgccaucucg                                                   20


<210>  16350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16350
gcucacugua accucugccu                                                   20


<210>  16351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16351
cuguaaccuc ugccucccug                                                   20


<210>  16352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16352
gccucccugg uucaagcgau                                                   20


<210>  16353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16353
cugguucaag cgauucuccu                                                   20


<210>  16354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16354
ugccucagcc ucucaaguag                                                   20


<210>  16355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16355
gccucucaag uagcugggau                                                   20


<210>  16356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16356
caaguagcug ggauuacagg                                                   20


<210>  16357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16357
aguagcuggg auuacaggug                                                   20


<210>  16358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16358
accaaaaaua caaaauuagc                                                   20


<210>  16359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16359
ugaccucaag ugaugcaccu                                                   20


<210>  16360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16360
agugaugcac cugccucgau                                                   20


<210>  16361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16361
aucucccaaa augcugggau                                                   20


<210>  16362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16362
caaaaugcug ggauuacagg                                                   20


<210>  16363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16363
cgccuguaau cccagcauuu                                                   20


<210>  16364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16364
cagccccuuc uugauucuug                                                   20


<210>  16365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16365
uuauagaugu ugauaaaaau                                                   20


<210>  16366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16366
caagcauuuu uaucaacauc                                                   20


<210>  16367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16367
ucucacaagc auuuuuauca                                                   20


<210>  16368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16368
acagaugcag ggcucuuagc                                                   20


<210>  16369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16369
uagcugcuuu gcacacuucu                                                   20


<210>  16370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16370
uuaauucaau aaacuguuau                                                   20


<210>  16371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16371
gauuuuccuc uacuauuuac                                                   20


<210>  16372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16372
acuauuuaca caauuuaaau                                                   20


<210>  16373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16373
gagucgcuua augucucacu                                                   20


<210>  16374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16374
gagaugaccc guuauuguac                                                   20


<210>  16375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16375
cuugucuuuc uacagugugu                                                   20


<210>  16376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16376
ucaacacacu guagaaagac                                                   20


<210>  16377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16377
acuaaagcag gauuucaggu                                                   20


<210>  16378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16378
uacuuguuga acacaaacag                                                   20


<210>  16379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16379
ucuguuaaga cguucgggua                                                   20


<210>  16380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16380
uuaagaggca ggcgcuguug                                                   20


<210>  16381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16381
uaaggaguag cagcguuuug                                                   20


<210>  16382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16382
cagcugauua ugccaacagc                                                   20


<210>  16383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16383
guccaugauu gagccaagag                                                   20


<210>  16384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16384
aucauggacu gagccaaaaa                                                   20


<210>  16385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16385
uggcucaauc auggacugag                                                   20


<210>  16386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16386
ccaggaggac gaggucuguc                                                   20


<210>  16387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16387
uggggaguga agggaaggau                                                   20


<210>  16388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16388
uccuccuggg gagugaaggg                                                   20


<210>  16389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16389
acagugacag accucguccu                                                   20


<210>  16390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16390
gcccuccaca gugacagacc                                                   20


<210>  16391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16391
ucugcaaccu cgcuaguuaa                                                   20


<210>  16392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16392
gcaaccucgc uaguuaacuu                                                   20


<210>  16393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16393
cuaguuaacu uccagucccu                                                   20


<210>  16394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16394
gaguuucugu uuagaaugcu                                                   20


<210>  16395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16395
gagggacugg aaguuaacua                                                   20


<210>  16396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16396
aucucauuua gaauugcaag                                                   20


<210>  16397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16397
uuuagaauug caaggaaacc                                                   20


<210>  16398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16398
ugagguauua auagugauuc                                                   20


<210>  16399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16399
ugagauauug uaugaagugc                                                   20


<210>  16400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16400
cagcgugaaa uucuuccugu                                                   20


<210>  16401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16401
cacacaaaua ucaaauccau                                                   20


<210>  16402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16402
uuuuuuucac uguaguuguu                                                   20


<210>  16403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16403
cuuuggcaca aacuuggccu                                                   20


<210>  16404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16404
uuggcacaaa cuuggccucc                                                   20


<210>  16405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16405
caguuugaug gcuuaucuuc                                                   20


<210>  16406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16406
gccuugugac uugcuggggu                                                   20


<210>  16407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16407
uccaguguga ggccaggcuu                                                   20


<210>  16408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16408
agugugaggc caggcuugua                                                   20


<210>  16409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16409
cacuggagga gccaaggcgc                                                   20


<210>  16410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16410
cugacgccag ccugaggaac                                                   20


<210>  16411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16411
ggcuggcguc agcgagggcc                                                   20


<210>  16412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16412
gccugcacca uguuccucag                                                   20


<210>  16413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16413
ugcuccgccu gcaccauguu                                                   20


<210>  16414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16414
ggguaacagu uguggcaaga                                                   20


<210>  16415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16415
uucgugcuuc caccaacgac                                                   20


<210>  16416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16416
gaauacagca gacuauuaga                                                   20


<210>  16417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16417
aggagauaua uaugguugau                                                   20


<210>  16418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16418
uagaguucuc ugaauacagc                                                   20


<210>  16419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16419
cuggccacac acuucuugga                                                   20


<210>  16420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16420
cucacuggcc acacacuucu                                                   20


<210>  16421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16421
gagguggggg uagaggagga                                                   20


<210>  16422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16422
gagaugugua agucccaagc                                                   20


<210>  16423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16423
acccccaccu cugagaugug                                                   20


<210>  16424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16424
ucuaccccca ccucugagau                                                   20


<210>  16425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16425
uccucuaccc ccaccucuga                                                   20


<210>  16426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16426
guguuccucc uccucuaccc                                                   20


<210>  16427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16427
gcccacucag uguuccuccu                                                   20


<210>  16428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16428
cauugccaaa gugugucagc                                                   20


<210>  16429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16429
uugccaaagu gugucagcaa                                                   20


<210>  16430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16430
acagguccug ugcuuugaau                                                   20


<210>  16431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16431
gaacaccagc acuacugugc                                                   20


<210>  16432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16432
uuucacuuaa auuuguuuuu                                                   20


<210>  16433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16433
aaaaaaaaaa aaacaaauuu                                                   20


<210>  16434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16434
gucucaaaaa aaaaaaaaac                                                   20


<210>  16435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16435
gucgcccagg cuggagugca                                                   20


<210>  16436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16436
agccugggcg acagagcaag                                                   20


<210>  16437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16437
gcucacugca agcucugcau                                                   20


<210>  16438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16438
cugcaagcuc ugcauccugg                                                   20


<210>  16439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16439
gcauccuggg uucaugccau                                                   20


<210>  16440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16440
ugccucagcc ucccgaguag                                                   20


<210>  16441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16441
gccucccgag uagcugggac                                                   20


<210>  16442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16442
cgaguagcug ggacuacagg                                                   20


<210>  16443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16443
ggaggcugag gcaggagaau                                                   20


<210>  16444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16444
acuaaaaaua caaaaaaaag                                                   20


<210>  16445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16445
aucuccugac cucgugaucu                                                   20


<210>  16446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16446
ugaccucgug aucugcccgu                                                   20


<210>  16447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16447
ugaucugccc gucccggccu                                                   20


<210>  16448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16448
caaagugcug ggauuacagg                                                   20


<210>  16449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16449
cgccuguaau cccagcacuu                                                   20


<210>  16450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16450
uuucacuuaa auuuauguuu                                                   20


<210>  16451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16451
aauaccuguu cauacuuaag                                                   20


<210>  16452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16452
aguguuuuaa uuguagcuau                                                   20


<210>  16453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16453
ugacucuagu guuuuaauug                                                   20


<210>  16454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16454
aauauauagu aaguacauca                                                   20


<210>  16455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16455
ugaaacucca auauauagua                                                   20


<210>  16456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16456
caugcuuauu aauaccccaa                                                   20


<210>  16457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16457
aaaaaaauca uguaauuucu                                                   20


<210>  16458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16458
caaaucucac uuaagacugg                                                   20


<210>  16459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16459
aaucucacuu aagacugggc                                                   20


<210>  16460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16460
cuuaagacug ggcugaguag                                                   20


<210>  16461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16461
gcccagucuu aagugagauu                                                   20


<210>  16462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16462
gacuugagua gccuucugcg                                                   20


<210>  16463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16463
agucugagcu uuuuucugcu                                                   20


<210>  16464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16464
cagaaggcua cucaagucug                                                   20


<210>  16465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16465
cucgcagaag gcuacucaag                                                   20


<210>  16466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16466
ucacucgcag aaggcuacuc                                                   20


<210>  16467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16467
aaauagagug ucauuaucug                                                   20


<210>  16468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16468
auuuagaguu uacagcugcc                                                   20


<210>  16469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16469
ucagauaaug acacucuauu                                                   20


<210>  16470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16470
guguggcagc aucgcccucu                                                   20


<210>  16471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16471
aucugacacg uucugaucgu                                                   20


<210>  16472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16472
aaccaauuuc acauucacac                                                   20


<210>  16473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16473
ugcucaaacc aauuucacau                                                   20


<210>  16474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16474
gauauacucc ugcucaaacc                                                   20


<210>  16475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16475
gcacucagau auacuccugc                                                   20


<210>  16476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16476
ucugcacuca gauauacucc                                                   20


<210>  16477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16477
uucucugcuu cccuuuuauu                                                   20


<210>  16478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16478
gcuucccuuu uauucccauu                                                   20


<210>  16479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16479
agaaaguguc uacccaguug                                                   20


<210>  16480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16480
cgagugucac aaagaaccgu                                                   20


<210>  16481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16481
ugagguuugu cuucaacugg                                                   20


<210>  16482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16482
ggcgugucag ugcuagagag                                                   20


<210>  16483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16483
agcacugaca cgccugaguu                                                   20


<210>  16484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16484
cuagcacuga cacgccugag                                                   20


<210>  16485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16485
aguuuccucu cuagcacuga                                                   20


<210>  16486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16486
gcuccaguuu ccucucuagc                                                   20


<210>  16487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16487
uguuauaaaa gcuuuaaaac                                                   20


<210>  16488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16488
ucaguugcug cugcuuaucu                                                   20


<210>  16489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16489
gcaagucagc auccuugccc                                                   20


<210>  16490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16490
cuggacucaa ggcuaaccug                                                   20


<210>  16491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16491
aggcuaaccu gggguuggcu                                                   20


<210>  16492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16492
ccuccaaaau aaguuugaau                                                   20


<210>  16493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16493
aaaauaaguu ugaauuuaaa                                                   20


<210>  16494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16494
caauuuaaau ucaaacuuau                                                   20


<210>  16495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16495
agauuuugca aaaauguucc                                                   20


<210>  16496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16496
uuaaaaagga auggaauuua                                                   20


<210>  16497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16497
guuacugucc ugcuaaauuc                                                   20


<210>  16498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16498
uggaguccau gugggagcug                                                   20


<210>  16499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16499
aggagcacgg gucucaguua                                                   20


<210>  16500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16500
cacauggacu ccaggagcac                                                   20


<210>  16501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16501
gcacaagcau uugcacgcuu                                                   20


<210>  16502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16502
ugacugcauu accuuccucc                                                   20


<210>  16503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16503
uauaguugcu gugggcacca                                                   20


<210>  16504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16504
agauucgucc caguuaaauc                                                   20


<210>  16505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16505
aaaaugacag uuaaauuuug                                                   20


<210>  16506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16506
caaauauucc uaccccacau                                                   20


<210>  16507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16507
auuuccuucu agacguaaau                                                   20


<210>  16508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16508
ccugaaaggg ucuguuuccc                                                   20


<210>  16509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16509
uagggaaaca gacccuuuca                                                   20


<210>  16510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16510
guucuccuag ggaaacagac                                                   20


<210>  16511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16511
gucaacacug auuuuccaca                                                   20


<210>  16512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16512
aaaaaaaaac aaaaaaaaac                                                   20


<210>  16513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16513
aucucaaaaa aaaaacaaaa                                                   20


<210>  16514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16514
cucugucacc caggcuggag                                                   20


<210>  16515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16515
gucacccagg cuggagugca                                                   20


<210>  16516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16516
agccugggug acagagcgag                                                   20


<210>  16517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16517
gcucacugcc agcuccgccu                                                   20


<210>  16518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16518
cugccagcuc cgccucagag                                                   20


<210>  16519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16519
gccucagagg uucacgccau                                                   20


<210>  16520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16520
gagguucacg ccauucuccu                                                   20


<210>  16521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16521
gaggcggagc uggcagugag                                                   20


<210>  16522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16522
ugccucagcc ucccgaguag                                                   20


<210>  16523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16523
gccucccgag uagcugggac                                                   20


<210>  16524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16524
cgaguagcug ggacuacagg                                                   20


<210>  16525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16525
ggaggcugag gcaggagaau                                                   20


<210>  16526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16526
acuaaaaaua caaaaaauua                                                   20


<210>  16527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16527
ucucuacuaa aaauacaaaa                                                   20


<210>  16528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16528
aucuccugac cucgugaucu                                                   20


<210>  16529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16529
ugaccucgug aucugcccgc                                                   20


<210>  16530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16530
ugaucugccc gccucggccu                                                   20


<210>  16531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16531
gccucccaaa gugcugggau                                                   20


<210>  16532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16532
caaagugcug ggaugacagg                                                   20


<210>  16533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16533
cgccugucau cccagcacuu                                                   20


<210>  16534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16534
uucauuaaaa gcagacccca                                                   20


<210>  16535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16535
ccucaggaaa uagucauugg                                                   20


<210>  16536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16536
ucaggaaaua gucauuggga                                                   20


<210>  16537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16537
ggaaauaguc auugggaacu                                                   20


<210>  16538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16538
uagugucaaa ggaaaggaaa                                                   20


<210>  16539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16539
ccagucagcc uccuaguguc                                                   20


<210>  16540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16540
gccccugcug cccacagcca                                                   20


<210>  16541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16541
cagccccugc ugcccacagc                                                   20


<210>  16542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16542
ucucagcccc ugcugcccac                                                   20


<210>  16543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16543
caggggggca cggguacccc                                                   20


<210>  16544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16544
ggggggcacg gguaccccaa                                                   20


<210>  16545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16545
ggcuucccuu gggguacccg                                                   20


<210>  16546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16546
gguuucaugu uuguucugau                                                   20


<210>  16547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16547
caguucuuaa gauucaguac                                                   20


<210>  16548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16548
augcugauaa agauuuauug                                                   20


<210>  16549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16549
auaaaucuuu aucagcauag                                                   20


<210>  16550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16550
ugcuguaugu uugcauucug                                                   20


<210>  16551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16551
gggcagaaug caaacauaca                                                   20


<210>  16552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16552
gagaaaacca ggccauaugc                                                   20


<210>  16553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16553
gagccucugg gcagaaugca                                                   20


<210>  16554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16554
augcuuuauc cauggaagcu                                                   20


<210>  16555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16555
ccgucagguu gggaaagcug                                                   20


<210>  16556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16556
caugcagccc uuacgugucg                                                   20


<210>  16557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16557
cagaugguug ggggacgaag                                                   20


<210>  16558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16558
gaugguuggg ggacgaaggu                                                   20


<210>  16559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16559
uuuggguauc uuauuacuaa                                                   20


<210>  16560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16560
ucuguucacg uuaauggcag                                                   20


<210>  16561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16561
uggaauuuau uauuuguuuu                                                   20


<210>  16562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16562
uuggaaaaac aaauaauaaa                                                   20


<210>  16563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16563
ggguauagua aaguuguuga                                                   20


<210>  16564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16564
acaacuuuac uauacccuga                                                   20


<210>  16565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16565
auucugaaau cagccuagau                                                   20


<210>  16566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16566
ugcuuaucug cauaaauuuu                                                   20


<210>  16567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16567
uaaaaauuaa uguauaucuc                                                   20


<210>  16568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16568
agacuuguuu ggaaguaguu                                                   20


<210>  16569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16569
accacaagau uucauuccac                                                   20


<210>  16570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16570
aagaagauuu aaaaacuagu                                                   20


<210>  16571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16571
gcagcuuuuu cuugcuagau                                                   20


<210>  16572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16572
acaucuagca agaaaaagcu                                                   20


<210>  16573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16573
acuguguuuu ggggcaaguu                                                   20


<210>  16574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16574
uuugaguuuc aauuucuuca                                                   20


<210>  16575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16575
aaagagaaac aguaacuugc                                                   20


<210>  16576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16576
ugaagaaauu gaaacucaaa                                                   20


<210>  16577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16577
uugcucuuga agaaauugaa                                                   20


<210>  16578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16578
gccucuuugc ucuugaagaa                                                   20


<210>  16579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16579
ucugccucuu ugcucuugaa                                                   20


<210>  16580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16580
ccucugccuc uuugcucuug                                                   20


<210>  16581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16581
gaaccuuuac acaugucccu                                                   20


<210>  16582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16582
gcgcgagggc acagauggga                                                   20


<210>  16583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16583
cgcagagcag ggacaugugu                                                   20


<210>  16584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16584
aaccccaccc cugccacagu                                                   20


<210>  16585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16585
gauucccuaa aaacaaaaac                                                   20


<210>  16586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16586
gugauggcau cauggccagu                                                   20


<210>  16587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16587
ggcucugcau gugugucugu                                                   20


<210>  16588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16588
gcaugugugu cuguguaugu                                                   20


<210>  16589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16589
aaccaguacc uucacauaca                                                   20


<210>  16590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16590
uuugaaacgu cucuaaccag                                                   20


<210>  16591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16591
ucucuuuuga aacgucucua                                                   20


<210>  16592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16592
cuucucuuuu gaaacgucuc                                                   20


<210>  16593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16593
cagcaauuug uaaucuucuc                                                   20


<210>  16594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16594
gcaauuugua aucuucucag                                                   20


<210>  16595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16595
gggaaaaaaa uucaagaaac                                                   20


<210>  16596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16596
cauccagugg uauuggagau                                                   20


<210>  16597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16597
uccaguggua uuggagauau                                                   20


<210>  16598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16598
aauaccacug gaugagagau                                                   20


<210>  16599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16599
agcaaaauca ucaggcaaaa                                                   20


<210>  16600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16600
uggguuccuu auuuaagcuc                                                   20


<210>  16601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16601
uuccacaggc ugggggcuug                                                   20


<210>  16602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16602
uucauaaaac cacacuagcu                                                   20


<210>  16603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16603
aagaaagauu ugcaacucau                                                   20


<210>  16604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16604
cugacuccuu ugcuggaauc                                                   20


<210>  16605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16605
uuugcuggaa ucuguaggcu                                                   20


<210>  16606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16606
cagaugugag aauggcacua                                                   20


<210>  16607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16607
caucugggag uuugcaaggg                                                   20


<210>  16608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16608
aaguaguagu gccauucuca                                                   20


<210>  16609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16609
gcgugugugc agaagagcau                                                   20


<210>  16610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16610
ucugcacaca cgcugagucg                                                   20


<210>  16611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16611
caacacagcc cgguugaugc                                                   20


<210>  16612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16612
caguguuuac auagcuaagc                                                   20


<210>  16613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16613
guguuuacau agcuaagcca                                                   20


<210>  16614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16614
caagggcuuc agauucacac                                                   20


<210>  16615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16615
aaguccagga aaccaaacac                                                   20


<210>  16616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16616
cagaugacca agcuucccag                                                   20


<210>  16617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16617
cacagaugac caagcuuccc                                                   20


<210>  16618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16618
gacccucuca cagaugacca                                                   20


<210>  16619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16619
cugacccucu cacagaugac                                                   20


<210>  16620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16620
cugacccuuc gguggcaugc                                                   20


<210>  16621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16621
gggccggaga gaguaugugu                                                   20


<210>  16622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16622
ggcccugaga caugcacaca                                                   20


<210>  16623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16623
ccggcccuga gacaugcaca                                                   20


<210>  16624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16624
cuccggcccu gagacaugca                                                   20


<210>  16625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16625
gugacacaua cucucuccgg                                                   20


<210>  16626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16626
cagugacaca uacucucucc                                                   20


<210>  16627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16627
gaccucucag ugacacauac                                                   20


<210>  16628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16628
uugacacaca cacaaacacu                                                   20


<210>  16629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16629
gugaagggca caaugcaacc                                                   20


<210>  16630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16630
gaccccucag ugaagggcac                                                   20


<210>  16631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16631
cgugugugug uguguacgug                                                   20


<210>  16632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16632
gugacacaca cacacguaca                                                   20


<210>  16633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16633
gaccccucag ugacacacac                                                   20


<210>  16634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16634
gugacaugua cgcacacaca                                                   20


<210>  16635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16635
gaccccucag ugacauguac                                                   20


<210>  16636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16636
gugugugugc ucaugugugu                                                   20


<210>  16637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16637
ugugugugca uacgugucac                                                   20


<210>  16638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16638
gugacacgua ugcacacaca                                                   20


<210>  16639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16639
gaccccucag ugacacguau                                                   20


<210>  16640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16640
gugugugcuc auuugugagc                                                   20


<210>  16641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16641
uuugugagcg uaugugucac                                                   20


<210>  16642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16642
caaaugagca cacacagagg                                                   20


<210>  16643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16643
gugacacaua cgcucacaaa                                                   20


<210>  16644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16644
gacccccuca gugacacaua                                                   20


<210>  16645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16645
gugugugugc ucauguguga                                                   20


<210>  16646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16646
ugugugagcg uaugugucac                                                   20


<210>  16647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16647
cacaugagca cacacacaga                                                   20


<210>  16648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16648
gugacacaua cgcucacaca                                                   20


<210>  16649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16649
gacccccuca gugacacaua                                                   20


<210>  16650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16650
gugugugugc ucauguguga                                                   20


<210>  16651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16651
ugugugagcg uaugugucac                                                   20


<210>  16652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16652
cacaugagca cacacacaga                                                   20


<210>  16653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16653
gugacacaua cgcucacaca                                                   20


<210>  16654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16654
ugacauugag ggucagagug                                                   20


<210>  16655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16655
augucaugag cacauaggaa                                                   20


<210>  16656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16656
gacccucaau gucaugagca                                                   20


<210>  16657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16657
uguguuagac caaaauaaga                                                   20


<210>  16658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16658
gucauuagau agauaaggga                                                   20


<210>  16659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16659
cucugucauu agauagauaa                                                   20


<210>  16660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16660
agaauaaucu acuugauuca                                                   20


<210>  16661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16661
aauucaaaag ucaauuugaa                                                   20


<210>  16662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16662
uauaauuuaa caccacuucu                                                   20


<210>  16663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16663
gaacacugau cauuuuguga                                                   20


<210>  16664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16664
uccucugaac acugaucauu                                                   20


<210>  16665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16665
uaccauaaac caaguaugug                                                   20


<210>  16666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16666
acaucuacaa aaugcuuuca                                                   20


<210>  16667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16667
caacaucuac aaaaugcuuu                                                   20


<210>  16668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16668
gcagcccaua guccacgacc                                                   20


<210>  16669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16669
uuguauuaag aggaacaaau                                                   20


<210>  16670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16670
uaauacaaag aggucgugga                                                   20


<210>  16671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16671
uuuccugcau cagcuuuauu                                                   20


<210>  16672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16672
uuuuggguuu caagcucuuu                                                   20


<210>  16673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16673
guaacauuga caccaccacc                                                   20


<210>  16674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16674
uccaguacca ucagguaaga                                                   20


<210>  16675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16675
uaccugaugg uacuggauga                                                   20


<210>  16676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16676
cuguuaacug uguuacuuug                                                   20


<210>  16677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16677
ccaucccccu gcaccggcau                                                   20


<210>  16678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16678
cuccccaucc cccugcaccg                                                   20


<210>  16679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16679
accacacccc cccacccccc                                                   20


<210>  16680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16680
ccaacuccac cacacccccc                                                   20


<210>  16681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16681
ugccacugca ccuccccaac                                                   20


<210>  16682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16682
aaaaaaaaaa aaggauacac                                                   20


<210>  16683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16683
aucucaaaaa aaaaaaaagg                                                   20


<210>  16684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16684
cuccgucgcc caggcuggag                                                   20


<210>  16685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16685
ccgucgccca ggcuggagug                                                   20


<210>  16686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16686
gucgcccagg cuggagugug                                                   20


<210>  16687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16687
agccugggcg acggagagag                                                   20


<210>  16688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16688
uugcaagcuc caccucccgg                                                   20


<210>  16689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16689
accucccggg uuuaagcaau                                                   20


<210>  16690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16690
cggguuuaag caauucuccu                                                   20


<210>  16691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16691
ugccuccacc ucccgaguag                                                   20


<210>  16692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16692
accucccgag uagcugggau                                                   20


<210>  16693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16693
cgaguagcug ggauuacagg                                                   20


<210>  16694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16694
ggagguggag gcaggagaau                                                   20


<210>  16695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16695
acuaaaaaua caaaaaaaaa                                                   20


<210>  16696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16696
ugaccucaag ugauccuccu                                                   20


<210>  16697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16697
agugauccuc cugccuuggc                                                   20


<210>  16698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16698
ugccuuggcc ucccaaagug                                                   20


<210>  16699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16699
caaagugcua ggauuacagg                                                   20


<210>  16700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16700
cgccuguaau ccuagcacuu                                                   20


<210>  16701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16701
uguggcugug cccacuuuaa                                                   20


<210>  16702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16702
uggucugaga gucacgagau                                                   20


<210>  16703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16703
gaccaggagu caggugaacu                                                   20


<210>  16704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16704
cagaccagga gucaggugaa                                                   20


<210>  16705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16705
ugacucucag accaggaguc                                                   20


<210>  16706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16706
cuaucuugaa cgaucucgug                                                   20


<210>  16707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16707
uuuccaaaac gaggaccaaa                                                   20


<210>  16708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16708
uuuuggaaaa gagggccuca                                                   20


<210>  16709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16709
acucugaaau aaaaacuuua                                                   20


<210>  16710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16710
gaaauaaaaa cuuuauuugu                                                   20


<210>  16711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16711
aagaaaaaga ccuuagcccu                                                   20


<210>  16712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16712
aaaugucuuu gaauucuuau                                                   20


<210>  16713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16713
gccuuccuca aaaugucuuu                                                   20


<210>  16714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16714
cuuuuuaaau gacuucuccu                                                   20


<210>  16715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16715
uuuuaaauga cuucuccuuu                                                   20


<210>  16716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16716
uuucuuuuaa cuugcacugu                                                   20


<210>  16717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16717
cuuauuuugu caauucuuuu                                                   20


<210>  16718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16718
uaagaagcag cacuuucuuu                                                   20


<210>  16719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16719
uuaugauaca uguacuuuug                                                   20


<210>  16720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16720
uuuucagacc ucuuuaugau                                                   20


<210>  16721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16721
gccugccacc accugcuugc                                                   20


<210>  16722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16722
augacaccca cccacccaag                                                   20


<210>  16723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16723
ccaugacacc cacccaccca                                                   20


<210>  16724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16724
ucuccaugac acccacccac                                                   20


<210>  16725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16725
cugaacaugu ggcugaugaa                                                   20


<210>  16726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16726
ggauaugucu guuuagaaau                                                   20


<210>  16727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16727
accauguaua ccucugggaa                                                   20


<210>  16728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16728
gggaagcagg ugcucuucag                                                   20


<210>  16729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16729
ucaguagauu gccucugcag                                                   20


<210>  16730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16730
gcagagaaca cagaauugaa                                                   20


<210>  16731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16731
gcagaggcaa ucuacugaag                                                   20


<210>  16732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16732
uugccuuugu ggacauucac                                                   20


<210>  16733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16733
gauugugaaa uauuacaaau                                                   20


<210>  16734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16734
ugagcaaagu gugcaccuug                                                   20


<210>  16735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16735
ggaggauuug ccaucauugu                                                   20


<210>  16736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16736
agggcacaua caaggugcac                                                   20


<210>  16737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16737
ugucauagag uggggguugc                                                   20


<210>  16738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16738
augacaugag aaauguaggg                                                   20


<210>  16739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16739
cugggaucac aucuguuugg                                                   20


<210>  16740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16740
aggauccaaa cagaugugau                                                   20


<210>  16741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16741
uggcagcaga cuuucuaauu                                                   20


<210>  16742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16742
uauagguguu ggagauguuc                                                   20


<210>  16743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16743
aacaccuaua agagcgugca                                                   20


<210>  16744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16744
uuguggcacu gcugcaggac                                                   20


<210>  16745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16745
acagauagcu gacaucaucc                                                   20


<210>  16746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16746
caauguuagc caaacagcag                                                   20


<210>  16747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16747
uccuucaguc cuaaucugug                                                   20


<210>  16748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16748
gugcuaguca ugggacagcu                                                   20


<210>  16749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16749
caaugccauc ucagguuggu                                                   20


<210>  16750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16750
gguugguauu gcccaccuac                                                   20


<210>  16751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16751
gagagguuau ggaggugauc                                                   20


<210>  16752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16752
gagcuguggg auccccccug                                                   20


<210>  16753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16753
cggagcugug ggaucccccc                                                   20


<210>  16754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16754
auaaccucuc ggagcugugg                                                   20


<210>  16755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16755
aaagcugugu gcugccugau                                                   20


<210>  16756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16756
ccccagcacu cuaaagcugu                                                   20


<210>  16757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16757
aaagcccgaa cccuuaccuc                                                   20


<210>  16758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16758
uacacugccu ccugcauucu                                                   20


<210>  16759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16759
ugcauucugg ucaacccagu                                                   20


<210>  16760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16760
cucugucacc caggcuagag                                                   20


<210>  16761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16761
gucacccagg cuagagugca                                                   20


<210>  16762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16762
agccugggug acagagugag                                                   20


<210>  16763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16763
cugcaacaac cucugccucc                                                   20


<210>  16764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16764
gccucccagg uucaaccaau                                                   20


<210>  16765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16765
cagguucaac caauucuccc                                                   20


<210>  16766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16766
caccucagcc uccugaguag                                                   20


<210>  16767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16767
gccuccugag uagcaaggac                                                   20


<210>  16768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16768
ugaguagcaa ggaccacagg                                                   20


<210>  16769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16769
ggaggcugag gugggagaau                                                   20


<210>  16770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16770
acuaaaaaua caaaaaacua                                                   20


<210>  16771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16771
ucucuacuaa aaauacaaaa                                                   20


<210>  16772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16772
cuguguugcc caggcugguu                                                   20


<210>  16773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16773
ugggcgcaag ugauccacca                                                   20


<210>  16774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16774
caccuguaau gccagcacuu                                                   20


<210>  16775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16775
ccuggccuau ucaucacuaa                                                   20


<210>  16776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16776
guagcucaca gagaagggug                                                   20


<210>  16777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16777
cagagaaggg ugguggggac                                                   20


<210>  16778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16778
gugagcuaca gaggugcugc                                                   20


<210>  16779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16779
uugaggcagc ucugccagaa                                                   20


<210>  16780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16780
aggagguccc caccacccuu                                                   20


<210>  16781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16781
gccagaaaau cucaugagcu                                                   20


<210>  16782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16782
ugagcugccu ggcacagcuu                                                   20


<210>  16783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16783
ugagauuuuc uggcagagcu                                                   20


<210>  16784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16784
agcugugcca ggcagcucau                                                   20


<210>  16785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16785
gcaaauacau guuuguucau                                                   20


<210>  16786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16786
guauaguacg aguaguccgu                                                   20


<210>  16787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16787
uacuauacag aguaguuguu                                                   20


<210>  16788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16788
aaguuuaaau caaaugccaa                                                   20


<210>  16789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16789
agauaacauu ccauuaugaa                                                   20


<210>  16790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16790
ccagaagcca agaucccugu                                                   20


<210>  16791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16791
cugccuacag augguuuuag                                                   20


<210>  16792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16792
gauuacgcac agaaaagaau                                                   20


<210>  16793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16793
acucagauua cgcacagaaa                                                   20


<210>  16794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16794
acucuacuca gauuacgcac                                                   20


<210>  16795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16795
ccacaggugc auguugcauu                                                   20


<210>  16796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16796
aagaaggcag ggggucuuuc                                                   20


<210>  16797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16797
cuugcuuuuc uauugucugu                                                   20


<210>  16798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16798
uggauucuuc uguacggugu                                                   20


<210>  16799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16799
ucccuccugg auucuucugu                                                   20


<210>  16800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16800
cuucccuccu ggauucuucu                                                   20


<210>  16801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16801
caccgcagac accaccuaac                                                   20


<210>  16802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16802
ucaccagcug aacaaugcca                                                   20


<210>  16803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16803
aaugucacca gaucaccaaa                                                   20


<210>  16804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16804
uaggcuugua ucuuuccuuu                                                   20


<210>  16805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16805
gccuggaaug uuccuucccc                                                   20


<210>  16806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16806
uugcuuguac ccuaacagca                                                   20


<210>  16807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16807
acccucauug cuuguacccu                                                   20


<210>  16808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16808
uccacccuca uugcuuguac                                                   20


<210>  16809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16809
ccauggcugc cccacuccuc                                                   20


<210>  16810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16810
cuucccuccc cauggcugcc                                                   20


<210>  16811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16811
cucccuuccc uccccauggc                                                   20


<210>  16812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16812
ccccaccagg ccucacuccc                                                   20


<210>  16813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16813
acacuggccu caccccacca                                                   20


<210>  16814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16814
uccacacugg ccucacccca                                                   20


<210>  16815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16815
aggcuccucc acacuggccu                                                   20


<210>  16816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16816
caaggcuccu ccacacuggc                                                   20


<210>  16817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16817
ggaauaagaa ugauccugcu                                                   20


<210>  16818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16818
acucaggaau aagaaugauc                                                   20


<210>  16819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16819
aggcuauucu caacucagga                                                   20


<210>  16820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16820
cccucaaggc uauucucaac                                                   20


<210>  16821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16821
ccucccccuc aaggcuauuc                                                   20


<210>  16822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16822
gcccucaccu cccccucaag                                                   20


<210>  16823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16823
cauggguggc ccugcucugc                                                   20


<210>  16824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16824
agugccgggu cucacauggg                                                   20


<210>  16825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16825
caugccacau cuaagccacc                                                   20


<210>  16826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16826
cacaugccac aucuaagcca                                                   20


<210>  16827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16827
cucacaugcc acaucuaagc                                                   20


<210>  16828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16828
cucucacaug ccacaucuaa                                                   20


<210>  16829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16829
cccugaaauc acccccaaag                                                   20


<210>  16830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16830
ugcugccccc aaugucugcc                                                   20


<210>  16831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16831
gaccuccugc ugcccccaau                                                   20


<210>  16832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16832
acugcuacau ccagacaggc                                                   20


<210>  16833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16833
uuaggcaccu auggggucuc                                                   20


<210>  16834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16834
ccucauuagg caccuauggg                                                   20


<210>  16835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16835
uacaccugau gcuggccuca                                                   20


<210>  16836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16836
aggcucauac accugaugcu                                                   20


<210>  16837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16837
acaacuccag gcucauacac                                                   20


<210>  16838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16838
cgacaacucc aggcucauac                                                   20


<210>  16839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16839
gaugcugacc cccugcccca                                                   20


<210>  16840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16840
caguggaccc agacuggcug                                                   20


<210>  16841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16841
agccagucug gguccacugu                                                   20


<210>  16842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16842
ccagccaguc uggguccacu                                                   20


<210>  16843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16843
ucuccagcca gucugggucc                                                   20


<210>  16844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16844
uccucuccag ccagucuggg                                                   20


<210>  16845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16845
uccuccucuc cagccagucu                                                   20


<210>  16846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16846
guauucaagc uccuccuccu                                                   20


<210>  16847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16847
gcaggcucgg uauucaagcu                                                   20


<210>  16848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16848
aaggucaggu aggugagggg                                                   20


<210>  16849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16849
ccuaccugac cuuggagcug                                                   20


<210>  16850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16850
ccucaccuac cugaccuugg                                                   20


<210>  16851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16851
cccugcccca gcacuggcuc                                                   20


<210>  16852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16852
ugcacaaaau gccuuaaaaa                                                   20


<210>  16853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16853
gugcugccaa accugggcca                                                   20


<210>  16854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16854
ucagugcccu cggugcugcc                                                   20


<210>  16855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16855
aaaagcacuc aucagugccc                                                   20


<210>  16856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16856
uccaaaagca cucaucagug                                                   20


<210>  16857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16857
cuuugcuccu ccaaaagcac                                                   20


<210>  16858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16858
uguccuuuca ggaacacauu                                                   20


<210>  16859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16859
ccuguccuuu caggaacaca                                                   20


<210>  16860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16860
cuccuguccu uucaggaaca                                                   20


<210>  16861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16861
ucaaguaaaa ccuuuuccca                                                   20


<210>  16862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16862
guucccucuu caaguaaaac                                                   20


<210>  16863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16863
ggcuacugcc cuauuucucc                                                   20


<210>  16864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16864
ucuggcuacu gcccuauuuc                                                   20


<210>  16865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16865
uccucuggcu acugcccuau                                                   20


<210>  16866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16866
ccuccucugg cuacugcccu                                                   20


<210>  16867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16867
ucuccuccuc uggcuacugc                                                   20


<210>  16868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16868
gugcguaaac aggccuucau                                                   20


<210>  16869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16869
cuguugcuuc ugcccucagu                                                   20


<210>  16870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16870
ugugucauga acugauccuc                                                   20


<210>  16871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16871
gucauccaug cagccaaucc                                                   20


<210>  16872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16872
cagaguugcu ggggaggagg                                                   20


<210>  16873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16873
gggagaaccc acagugcucu                                                   20


<210>  16874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16874
ccagcaacuc ugggagaacc                                                   20


<210>  16875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16875
uccccagcaa cucugggaga                                                   20


<210>  16876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16876
gccuccuccc cagcaacucu                                                   20


<210>  16877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16877
ccaacucugc cuccucccca                                                   20


<210>  16878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16878
ccugugcuca ccaacucugc                                                   20


<210>  16879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16879
aggauuccug cauccuggac                                                   20


<210>  16880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16880
agucaguugu ucccuuguug                                                   20


<210>  16881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16881
caacacuggc cacaucuuac                                                   20


<210>  16882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16882
gcaaacagau gugguguuuu                                                   20


<210>  16883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16883
guagaaacaa aaauuggaaa                                                   20


<210>  16884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16884
ugccuguaau cccagcacuu                                                   20


<210>  16885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16885
caaagugcug ggauuacagg                                                   20


<210>  16886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16886
agcaaucugc cugccuuggc                                                   20


<210>  16887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16887
ggaguuugag accagccugg                                                   20


<210>  16888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16888
ugagcucaag caaucugccu                                                   20


<210>  16889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16889
aacuccugag cucaagcaau                                                   20


<210>  16890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16890
acuagaaaua caaaaaguag                                                   20


<210>  16891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16891
ggaggcugag gugggaggau                                                   20


<210>  16892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16892
ugaguuagcc aggacuacag                                                   20


<210>  16893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16893
gccuccugag uuagccagga                                                   20


<210>  16894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16894
caccucagcc uccugaguua                                                   20


<210>  16895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16895
agugauccuc ccaccucagc                                                   20


<210>  16896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16896
uggggcacag agugagacuc                                                   20


<210>  16897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16897
gugccccagg agugcagugg                                                   20


<210>  16898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16898
cucugugccc caggagugca                                                   20


<210>  16899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16899
guuagaaaga gagagagaga                                                   20


<210>  16900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16900
uucuaacaga gucucacucu                                                   20


<210>  16901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16901
cuuucuaaca gagucucacu                                                   20


<210>  16902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16902
cucuuucuaa cagagucuca                                                   20


<210>  16903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16903
cucucuuucu aacagagucu                                                   20


<210>  16904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16904
cucucucuuu cuaacagagu                                                   20


<210>  16905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16905
ucuuucucuc ucucucuuuc                                                   20


<210>  16906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16906
cuucuuucuc ucucucucuu                                                   20


<210>  16907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16907
cucuucuuuc ucucucucuc                                                   20


<210>  16908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16908
cucucucuuc uuucucucuc                                                   20


<210>  16909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16909
cucccucucu cuucuuucuc                                                   20


<210>  16910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16910
cuuccauuuc uuccauuuau                                                   20


<210>  16911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16911
ccuuccuccc uuccauuucu                                                   20


<210>  16912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16912
cuccccuucc ucccuuccau                                                   20


<210>  16913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16913
caaggcaacu ggcugaacuu                                                   20


<210>  16914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16914
auugcacugg guuaagugag                                                   20


<210>  16915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16915
cuuaacccag ugcaauggag                                                   20


<210>  16916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16916
ucucacuuaa cccagugcaa                                                   20


<210>  16917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16917
gcucuucuca cuuaacccag                                                   20


<210>  16918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16918
gugggugagg gggcaaggau                                                   20


<210>  16919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16919
cccacagagg uuuuguuuua                                                   20


<210>  16920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16920
cacaacaguu guaacaaaug                                                   20


<210>  16921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16921
aucccuccca caacaguugu                                                   20


<210>  16922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16922
aauauacaaa agugugaaaa                                                   20


<210>  16923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16923
uuuaaaagca uuuuaaguuc                                                   20


<210>  16924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16924
ucgucaccuu cccucauuua                                                   20


<210>  16925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16925
agggcaaauc aucauaauca                                                   20


<210>  16926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16926
caugaagccc uuggaguguu                                                   20


<210>  16927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16927
ugaagcccuu ggaguguuaa                                                   20


<210>  16928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16928
aagggcuuca ugagagucaa                                                   20


<210>  16929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16929
aauaauguau uuaacacucc                                                   20


<210>  16930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16930
cuccguccgg uagacaugcu                                                   20


<210>  16931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16931
guccgguaga caugcuuuua                                                   20


<210>  16932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16932
guaaaagcau gucuaccgga                                                   20


<210>  16933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16933
aaacacaaug gugagucucu                                                   20


<210>  16934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16934
ccauuguguu uggagugacg                                                   20


<210>  16935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16935
cgccuggcuc agcagaugaa                                                   20


<210>  16936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16936
ccuggcucag cagaugaauc                                                   20


<210>  16937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16937
gcagaugaau cuggacggcu                                                   20


<210>  16938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16938
gauuacuggg accaccccca                                                   20


<210>  16939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16939
gacauucugg gggugguccc                                                   20


<210>  16940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16940
agaagcccua cccaaacuga                                                   20


<210>  16941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16941
caagaagccc uacccaaacu                                                   20


<210>  16942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16942
guuccgcacc acccccacac                                                   20


<210>  16943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16943
cucugucgcc caggcuggag                                                   20


<210>  16944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16944
gucgcccagg cuggaguaca                                                   20


<210>  16945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16945
agccugggcg acagagugag                                                   20


<210>  16946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16946
gcucacugca agcucugccu                                                   20


<210>  16947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16947
cugcaagcuc ugccuuccag                                                   20


<210>  16948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16948
gccuuccagc uucacaccau                                                   20


<210>  16949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16949
ugccucagcc ucccgaguug                                                   20


<210>  16950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16950
gccucccgag uugcugggac                                                   20


<210>  16951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16951
cgaguugcug ggacuacaag                                                   20


<210>  16952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16952
ggaggcugag gcaggagaau                                                   20


<210>  16953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16953
acuaaaaaua caaaaaaauu                                                   20


<210>  16954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16954
ugaccucgug acccgcccau                                                   20


<210>  16955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16955
ugacccgccc aucucagccu                                                   20


<210>  16956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16956
gccucccaaa gugcugggau                                                   20


<210>  16957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16957
caaagugcug ggauuacagg                                                   20


<210>  16958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16958
cgccuguaau cccagcacuu                                                   20


<210>  16959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16959
aaaaaaaaua aaaaggccgg                                                   20


<210>  16960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16960
aucuccaaaa aaaauaaaaa                                                   20


<210>  16961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16961
gucacccagg cuggaguaca                                                   20


<210>  16962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16962
agccugggug acagagcaag                                                   20


<210>  16963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16963
acucacugca accuccgccu                                                   20


<210>  16964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16964
cugcaaccuc cgccucccgg                                                   20


<210>  16965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16965
gccucccggg uucaagcaau                                                   20


<210>  16966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16966
cggguucaag caauuuuccu                                                   20


<210>  16967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16967
gccucccgag uagcugggac                                                   20


<210>  16968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16968
cgaguagcug ggacuacagg                                                   20


<210>  16969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16969
ggaggcugag gcaggaaaau                                                   20


<210>  16970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16970
acuaaaaaua caaaaaauua                                                   20


<210>  16971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16971
ugaccuugug auccgcccgc                                                   20


<210>  16972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16972
gccucccaaa guguugggau                                                   20


<210>  16973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16973
caaaguguug ggauuacagg                                                   20


<210>  16974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16974
cgcaccaagc caagaguuug                                                   20


<210>  16975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16975
caccaagcca agaguuugca                                                   20


<210>  16976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16976
uggcuuggug cgagagccac                                                   20


<210>  16977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16977
cagaaaagca ggcauuaguu                                                   20


<210>  16978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16978
gugauagaga gguuuauugg                                                   20


<210>  16979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16979
aucacugagu cccaaagugu                                                   20


<210>  16980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16980
cuaucacuga gucccaaagu                                                   20


<210>  16981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16981
uauuuuacua uccuaccaau                                                   20


<210>  16982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16982
cggacgccua aaauaaacau                                                   20


<210>  16983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16983
aaauggccag aauucccgau                                                   20


<210>  16984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16984
uauucaggag cucuccuucu                                                   20


<210>  16985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16985
ugaauacgag aaagaacaau                                                   20


<210>  16986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16986
ccuucucucc guauuuaauc                                                   20


<210>  16987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16987
uucucuccgu auuuaaucuc                                                   20


<210>  16988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16988
ccguauuuaa ucuccuguac                                                   20


<210>  16989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16989
guauuuaauc uccuguacag                                                   20


<210>  16990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16990
uguacaguaa uuaauagguu                                                   20


<210>  16991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16991
uaaccuauua auuacuguac                                                   20


<210>  16992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16992
gauagaaagc auaccuugaa                                                   20


<210>  16993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16993
gaagugaagc aagaccaggu                                                   20


<210>  16994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16994
ugguucauac cugucuugaa                                                   20


<210>  16995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16995
uguccucagu agagaugcua                                                   20


<210>  16996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16996
guagagaugc uacagcagug                                                   20


<210>  16997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16997
acugaggaca agagacagaa                                                   20


<210>  16998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16998
ccucaggcag ggcagggcag                                                   20


<210>  16999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  16999
ggcagggcag ggcagugggg                                                   20


<210>  17000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17000
uggguuucaa cuucccugac                                                   20


<210>  17001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17001
cuuuuacugg cuucucuugg                                                   20


<210>  17002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17002
gauugucacc augugcuggc                                                   20


<210>  17003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17003
cugcagggca gccugccucc                                                   20


<210>  17004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17004
aauaaauacg uguaguauca                                                   20


<210>  17005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17005
uaaauuguuu ggaagcuccc                                                   20


<210>  17006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17006
ccaaggacag ugaugaggca                                                   20


<210>  17007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17007
ucacuguccu uggggagcuu                                                   20


<210>  17008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17008
uaagugcuug cugccuagau                                                   20


<210>  17009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17009
ccaccuuugc uagauucuga                                                   20


<210>  17010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17010
accuuugcua gauucugagc                                                   20


<210>  17011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17011
gaaucuagca aagguggaga                                                   20


<210>  17012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17012
gugaaugcuc agaaucuagc                                                   20


<210>  17013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17013
aacucaguga augcucagaa                                                   20


<210>  17014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17014
acugaugaca aaccaaguga                                                   20


<210>  17015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17015
uucgacaaca cagggcaucu                                                   20


<210>  17016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17016
gugaggaagg ugauacacag                                                   20


<210>  17017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17017
cugaggauga aauggcaggu                                                   20


<210>  17018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17018
guguaucacc uuccucacug                                                   20


<210>  17019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17019
cuguguauca ccuuccucac                                                   20


<210>  17020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17020
gcauuucacu uuagcgguua                                                   20


<210>  17021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17021
accuauauuu uuacuuuaua                                                   20


<210>  17022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17022
uuuccaccuu cagcuguuuu                                                   20


<210>  17023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17023
cucauuucca ccuucagcug                                                   20


<210>  17024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17024
aggaagacua augugauuca                                                   20


<210>  17025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17025
uuccccauuc ugcacuauac                                                   20


<210>  17026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17026
cagaguguag gagcugugcu                                                   20


<210>  17027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17027
gaguguagga gcugugcugc                                                   20


<210>  17028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17028
gagaguguau agugcagaau                                                   20


<210>  17029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17029
uacacucuga gaguguauag                                                   20


<210>  17030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17030
gccuugccca gugugccagu                                                   20


<210>  17031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17031
uacagcaaca aauauuuuca                                                   20


<210>  17032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17032
uggguauaua cccaaaagaa                                                   20


<210>  17033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17033
auggaugaau ggauaagcaa                                                   20


<210>  17034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17034
uguaagugga aucacauagu                                                   20


<210>  17035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17035
aggucccuca uguaagugga                                                   20


<210>  17036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17036
ccugcagccc cuggcaacca                                                   20


<210>  17037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17037
ccuccccugc agccccuggc                                                   20


<210>  17038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17038
ucaucuugua aaaauaacuc                                                   20


<210>  17039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17039
cuucaucuug uaaaaauaac                                                   20


<210>  17040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17040
uaacuauuuu uaacuguaca                                                   20


<210>  17041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17041
ugccugaaau ccaagcacuu                                                   20


<210>  17042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17042
aagugcuugg auuucaggca                                                   20


<210>  17043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17043
caaagugcuu ggauuucagg                                                   20


<210>  17044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17044
ugccuuggcc ucucaaagug                                                   20


<210>  17045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17045
agcaauccuc cugccuuggc                                                   20


<210>  17046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17046
uuggcucaag caauccuccu                                                   20


<210>  17047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17047
aacuccuugg cucaagcaau                                                   20


<210>  17048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17048
gcaacauggu aggaccccau                                                   20


<210>  17049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17049
ggagacugag gcuggaggau                                                   20


<210>  17050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17050
ugaguagcug ggaccacaug                                                   20


<210>  17051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17051
gucuccugag uagcugggac                                                   20


<210>  17052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17052
agccucaguc uccugaguag                                                   20


<210>  17053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17053
agcgauccuc cagccucagu                                                   20


<210>  17054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17054
ugggcucaag cgauccucca                                                   20


<210>  17055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17055
agugagaugu guucaugcca                                                   20


<210>  17056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17056
cuagagacuu aaccuccugg                                                   20


<210>  17057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17057
agccucggcu auagaguaag                                                   20


<210>  17058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17058
gcuauagagu aagacccugc                                                   20


<210>  17059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17059
auagccgagg cuggagugca                                                   20


<210>  17060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17060
aaaaaacaaa acaaaacaag                                                   20


<210>  17061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17061
ugucuuguuu uguuuuguuu                                                   20


<210>  17062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17062
caaaguguug ggauuacagg                                                   20


<210>  17063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17063
uggcuucaag ugauccuuuu                                                   20


<210>  17064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17064
ggcugguccc aagcuccugg                                                   20


<210>  17065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17065
auauguugcu caggcugguc                                                   20


<210>  17066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17066
acaaagaaaa ucaaaaacua                                                   20


<210>  17067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17067
caaguagcug ggacuacagg                                                   20


<210>  17068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17068
gccucccaag uagcugggac                                                   20


<210>  17069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17069
caccucagcc ucccaaguag                                                   20


<210>  17070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17070
ugagcucagg aguucgaggc                                                   20


<210>  17071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17071
agagauccuc ccaccucagc                                                   20


<210>  17072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17072
ggaguucgag gcugcaggga                                                   20


<210>  17073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17073
ugagcucaag agauccuccc                                                   20


<210>  17074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17074
aacuccugag cucaagagau                                                   20


<210>  17075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17075
cugcagccuc gaacuccuga                                                   20


<210>  17076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17076
agccugggcu acagaaugau                                                   20


<210>  17077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17077
uauuaaaaaa aaauccaaaa                                                   20


<210>  17078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17078
gguuuacuuu uuuuuuuuuu                                                   20


<210>  17079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17079
cagguuuacu uuuuuuuuuu                                                   20


<210>  17080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17080
uccuguguua aauuuggagg                                                   20


<210>  17081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17081
uguguuaaau uuggaggcca                                                   20


<210>  17082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17082
aaauuuaaca caggaggagg                                                   20


<210>  17083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17083
caccugaaau cccagcacuu                                                   20


<210>  17084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17084
caaagugcug ggauuucagg                                                   20


<210>  17085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17085
gccucccaaa gugcugggau                                                   20


<210>  17086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17086
agcgaucacc ccgccucagc                                                   20


<210>  17087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17087
agcucaagcg aucaccccgc                                                   20


<210>  17088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17088
ugcuauguug uccaggcugg                                                   20


<210>  17089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17089
acaaaaauaa aaaaauaaaa                                                   20


<210>  17090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17090
uggcuauuuu uuuuuauuuu                                                   20


<210>  17091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17091
ugccacuacu ccuggcuauu                                                   20


<210>  17092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17092
ggcucaugcc acuacuccug                                                   20


<210>  17093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17093
ugggcucagg cucaugccac                                                   20


<210>  17094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17094
cuacagcuug accuccuggg                                                   20


<210>  17095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17095
agccugggcg agaucgagac                                                   20


<210>  17096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17096
cccaggcugg agugcagugg                                                   20


<210>  17097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17097
aucucgccca ggcuggagug                                                   20


<210>  17098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17098
agagaaagaa aaugacaagg                                                   20


<210>  17099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17099
agagacaugg ucucgaucuc                                                   20


<210>  17100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17100
uuacaaacga ucguucuucu                                                   20


<210>  17101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17101
caagaaaaua gaaaggcaau                                                   20


<210>  17102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17102
agaaaauaga aaggcaauuc                                                   20


<210>  17103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17103
uauuuggacc augacuuaau                                                   20


<210>  17104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17104
uuuaagcggc uuaggaguca                                                   20


<210>  17105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17105
uaagccgcuu aaaggagaac                                                   20


<210>  17106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17106
uucuauaggu cuuugaucgu                                                   20


<210>  17107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17107
cuugggaacu agauucagau                                                   20


<210>  17108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17108
ugggaacuag auucagauag                                                   20


<210>  17109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17109
agcaguauuu acauuaugac                                                   20


<210>  17110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17110
aaaaaaaaaa gaaagaaaga                                                   20


<210>  17111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17111
gucucaaaaa aaaaaagaaa                                                   20


<210>  17112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17112
uguugcccau ccuggagugc                                                   20


<210>  17113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17113
aggaugggca acaagaguga                                                   20


<210>  17114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17114
gcucaccgca accucugccu                                                   20


<210>  17115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17115
ccgcaaccuc ugccucccag                                                   20


<210>  17116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17116
gccucccagg uucaagcaau                                                   20


<210>  17117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17117
cagguucaag caauucuccu                                                   20


<210>  17118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17118
ugccucagcc ucccgaguag                                                   20


<210>  17119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17119
gccucccgag uagcugggau                                                   20


<210>  17120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17120
cgaguagcug ggauuacggg                                                   20


<210>  17121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17121
ggaggcugag gcaggagaau                                                   20


<210>  17122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17122
acuaaaaaua caaaaaauua                                                   20


<210>  17123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17123
auguugaggc uggucucgaa                                                   20


<210>  17124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17124
acauggagaa acccugucuc                                                   20


<210>  17125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17125
aacuccugac cucaggugau                                                   20


<210>  17126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17126
ugaccucagg ugauccaccc                                                   20


<210>  17127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17127
ggugauccac ccgccucggc                                                   20


<210>  17128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17128
gccucccaaa gugcugggau                                                   20


<210>  17129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17129
caaagugcug ggauuacagg                                                   20


<210>  17130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17130
caccuguaau cccagcacuu                                                   20


<210>  17131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17131
ggccgggugc gguggcucac                                                   20


<210>  17132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17132
accaucuacu ugccaaauua                                                   20


<210>  17133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17133
aucucuacca ucuacuugcc                                                   20


<210>  17134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17134
ccaccucuau cucuaccauc                                                   20


<210>  17135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17135
auauuuuggu cugucaacuu                                                   20


<210>  17136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17136
gaagccucua uauuuugguc                                                   20


<210>  17137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17137
aaauagaacu aaacauguaa                                                   20


<210>  17138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17138
uaacaaucug aauuacaugu                                                   20


<210>  17139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17139
uuuauacuac cuccuaacaa                                                   20


<210>  17140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17140
ucuuuauuac gguagaguua                                                   20


<210>  17141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17141
accguaauaa agaugagauu                                                   20


<210>  17142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17142
aguuuaaacu gggguuuuau                                                   20


<210>  17143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17143
uacucuaguu uaaacugggg                                                   20


<210>  17144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17144
uggaaagugc aggcaagggu                                                   20


<210>  17145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17145
gcucugcuuu cuucuuuuca                                                   20


<210>  17146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17146
gcuuucuucu uuucauuuau                                                   20


<210>  17147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17147
cuuugucgcc uaggcugaag                                                   20


<210>  17148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17148
cacugcacuu caugccacug                                                   20


<210>  17149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17149
cucuagccuc gaacuccugg                                                   20


<210>  17150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17150
agccucgaac uccugggcuc                                                   20


<210>  17151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17151
aacuccuggg cucuagaguu                                                   20


<210>  17152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17152
ugggcucuag aguucuuccu                                                   20


<210>  17153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17153
agaguucuuc cugccucagc                                                   20


<210>  17154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17154
agagcccagg aguucgaggc                                                   20


<210>  17155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17155
gccuucuaag uagcugagac                                                   20


<210>  17156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17156
gcuacuuaga aggcugaggc                                                   20


<210>  17157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17157
uagcuucagg cgauccuccu                                                   20


<210>  17158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17158
ugccucugcc ucccaaaaug                                                   20


<210>  17159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17159
gccucccaaa augcugaggu                                                   20


<210>  17160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17160
caaaaugcug agguuauagg                                                   20


<210>  17161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17161
gcauuuuggg aggcagaggc                                                   20


<210>  17162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17162
ucucugcuuc cuguguuagu                                                   20


<210>  17163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17163
gcuuccugug uuaguuuugu                                                   20


<210>  17164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17164
ggugggcugu uuucacauga                                                   20


<210>  17165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17165
agcaggcugu guucucagcc                                                   20


<210>  17166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17166
gccccucaag uaggccuaug                                                   20


<210>  17167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17167
aguaggccua ugugauuggc                                                   20


<210>  17168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17168
ugcaaggcca aucacauagg                                                   20


<210>  17169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17169
gguccacaug ggccaaaugg                                                   20


<210>  17170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17170
cauuuggccc auguggacca                                                   20


<210>  17171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17171
ucaauggaau gcuguccagu                                                   20


<210>  17172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17172
ucaucaaugg aaugcugucc                                                   20


<210>  17173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17173
gggaguaagg gagaggagca                                                   20


<210>  17174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17174
cggagaccag ccccaccucc                                                   20


<210>  17175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17175
cuuacucccg gagaccagcc                                                   20


<210>  17176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17176
cccuuacucc cggagaccag                                                   20


<210>  17177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17177
ucucccuuac ucccggagac                                                   20


<210>  17178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17178
aaaauucuaa cugcugugcu                                                   20


<210>  17179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17179
caucccuuuu uaaggcaacu                                                   20


<210>  17180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17180
uuucucuuac uggauuuuug                                                   20


<210>  17181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17181
uacuggauuu uuguacacau                                                   20


<210>  17182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17182
aagauaugua ugcaaaaugu                                                   20


<210>  17183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17183
aauggaccaa ggcugaaaau                                                   20


<210>  17184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17184
uggcguggcc cgccuccaug                                                   20


<210>  17185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17185
augcuagcag gcucugguug                                                   20


<210>  17186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17186
gguugugcca aguucaguug                                                   20


<210>  17187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17187
acugaacuug gcacaaccag                                                   20


<210>  17188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17188
ugccugcacg gaacuuccag                                                   20


<210>  17189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17189
gccugcccac ccauuucguc                                                   20


<210>  17190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17190
gaaauccugc cucugccugc                                                   20


<210>  17191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17191
cucagaaauc cugccucugc                                                   20


<210>  17192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17192
cccucagaaa uccugccucu                                                   20


<210>  17193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17193
gcaaaaagcu agcuacuucu                                                   20


<210>  17194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17194
ucucugcaaa aagcuagcua                                                   20


<210>  17195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17195
ugggugccgg aacucuucuc                                                   20


<210>  17196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17196
cuugggugcc ggaacucuuc                                                   20


<210>  17197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17197
gcugcucucu ugggugccgg                                                   20


<210>  17198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17198
cagcugcucu cuugggugcc                                                   20


<210>  17199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17199
aggauucugu ggcgccgugc                                                   20


<210>  17200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17200
ucauggccuc ugcauucagc                                                   20


<210>  17201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17201
gcauucagcu gcugucaccc                                                   20


<210>  17202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17202
gcacaggcca uggccaaaau                                                   20


<210>  17203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17203
aguuuuugag ccuuacuugc                                                   20


<210>  17204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17204
aaaacuagag uccacuauga                                                   20


<210>  17205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17205
acuuuaaacu uauuacagug                                                   20


<210>  17206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17206
uggcaucaaa uccaaaccaa                                                   20


<210>  17207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17207
uccuggcauc aaauccaaac                                                   20


<210>  17208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17208
uuucuaagga cuagucuugc                                                   20


<210>  17209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17209
gacauguaga aggacacaga                                                   20


<210>  17210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17210
gugcagcuca aaugugguca                                                   20


<210>  17211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17211
aaugugguca cugucuuauu                                                   20


<210>  17212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17212
ccuuccaucu cacaauugag                                                   20


<210>  17213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17213
uuccaucuca caauugaggc                                                   20


<210>  17214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17214
caauugaggc aaaauauugu                                                   20


<210>  17215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17215
auugugagau ggaaggagag                                                   20


<210>  17216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17216
gcuggaaguc cuauuggaca                                                   20


<210>  17217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17217
guguggauag uggcuccugu                                                   20


<210>  17218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17218
uguaugagac agugcagguc                                                   20


<210>  17219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17219
uacaggagcc acuauccaca                                                   20


<210>  17220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17220
acagaccugc acugucucau                                                   20


<210>  17221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17221
caccaguaaa gcugcuucuc                                                   20


<210>  17222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17222
acucccacca guaaagcugc                                                   20


<210>  17223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17223
aagcccucca cucccaccag                                                   20


<210>  17224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17224
ccaagcccuc cacucccacc                                                   20


<210>  17225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17225
uaucuugaaa ccaaucaaau                                                   20


<210>  17226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17226
uguuuuuaua uaaguaaggu                                                   20


<210>  17227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17227
uguugggaga ggaggguauu                                                   20


<210>  17228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17228
caacaagagg aaaagcagga                                                   20


<210>  17229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17229
cccaacaaga ggaaaagcag                                                   20


<210>  17230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17230
ucucccaaca agaggaaaag                                                   20


<210>  17231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17231
uguuuacaac auuuggggua                                                   20


<210>  17232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17232
cuuuuggucc aagauagacu                                                   20


<210>  17233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17233
uuugguccaa gauagacugg                                                   20


<210>  17234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17234
ggugccauca ucuguuucua                                                   20


<210>  17235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17235
ugggccucug gugccaucau                                                   20


<210>  17236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17236
aauucagcca cauggacaac                                                   20


<210>  17237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17237
acacggccuu ccagcuuugc                                                   20


<210>  17238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17238
ccgugauuuu caaggacaca                                                   20


<210>  17239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17239
ucccugccug ccauccagac                                                   20


<210>  17240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17240
ugccacccug acuggguaua                                                   20


<210>  17241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17241
cugaguccug gucgugggug                                                   20


<210>  17242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17242
gggaggaagg ggcagcagcu                                                   20


<210>  17243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17243
accacccacg accaggacuc                                                   20


<210>  17244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17244
cggaggcaug cucaccccuu                                                   20


<210>  17245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17245
gugagcguca uggcacaucu                                                   20


<210>  17246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17246
ccccuuccuc uguggcagag                                                   20


<210>  17247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17247
guggcagagg ggauggcugc                                                   20


<210>  17248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17248
gccacagagg aaggggugag                                                   20


<210>  17249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17249
ucccuguccu uuccaaagcg                                                   20


<210>  17250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17250
uccaguauuc cugcuuugcc                                                   20


<210>  17251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17251
cuuccaguau uccugcuuug                                                   20


<210>  17252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17252
cucuuccagu auuccugcuu                                                   20


<210>  17253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17253
cagcauuaua auuguuagua                                                   20


<210>  17254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17254
uggguaugug guagguuuaa                                                   20


<210>  17255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17255
gugaaguauu ucccgcuuug                                                   20


<210>  17256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17256
caucaggcca cuucuugggu                                                   20


<210>  17257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17257
ucaggccacu ucuuggguug                                                   20


<210>  17258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17258
ccacuaucaa cccaagaagu                                                   20


<210>  17259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17259
acgccacaca gugacugggg                                                   20


<210>  17260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17260
ucuccacgcc acacagugac                                                   20


<210>  17261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17261
cugugucaua gcugaacaag                                                   20


<210>  17262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17262
gugucauagc ugaacaagcc                                                   20


<210>  17263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17263
gggcugggcu uguucagcua                                                   20


<210>  17264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17264
cugggcuggg cuuguucagc                                                   20


<210>  17265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17265
uagggcagaa accucucugg                                                   20


<210>  17266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17266
cgauggugga auugggaugc                                                   20


<210>  17267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17267
augguggaau ugggaugcga                                                   20


<210>  17268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17268
caaaaacacg gcuugcggag                                                   20


<210>  17269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17269
gcaagccgug uuuuugugag                                                   20


<210>  17270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17270
gggugcagcc ugcauccgcc                                                   20


<210>  17271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17271
uuuccugcac ugccaucgug                                                   20


<210>  17272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17272
gggcacuugg ucccuuucuc                                                   20


<210>  17273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17273
uccccugagu cccuuuggcu                                                   20


<210>  17274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17274
ggggaagaga aagggaccaa                                                   20


<210>  17275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17275
ccugugccac ccuugugauc                                                   20


<210>  17276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17276
gccuucuuuc ugucucagac                                                   20


<210>  17277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17277
gacugcugcu caucacuacu                                                   20


<210>  17278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17278
ucacuacucg ggacccuagg                                                   20


<210>  17279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17279
ggacccuagg aagggagguu                                                   20


<210>  17280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17280
cuuccuaggg ucccgaguag                                                   20


<210>  17281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17281
guggaaccuc ccuuccuagg                                                   20


<210>  17282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17282
ucucagccac guucucagug                                                   20


<210>  17283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17283
gccacguucu cagugccacu                                                   20


<210>  17284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17284
gugccacugu ugucuuuguu                                                   20


<210>  17285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17285
ggugugaagc cauggaaaug                                                   20


<210>  17286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17286
auacauuguc auaaaaccaa                                                   20


<210>  17287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17287
augugggaau ucggggaccc                                                   20


<210>  17288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17288
uuuccuucuu uugguucugu                                                   20


<210>  17289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17289
aggccuucac auccucugug                                                   20


<210>  17290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17290
gugucugguu ggggacaagg                                                   20


<210>  17291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17291
uuguccccaa ccagacacag                                                   20


<210>  17292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17292
ccuugucccc aaccagacac                                                   20


<210>  17293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17293
cguggugaca ggucacagcc                                                   20


<210>  17294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17294
uggugacagg ucacagcccc                                                   20


<210>  17295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17295
guccccuuuu acaggguggg                                                   20


<210>  17296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17296
caguccccuu uuacagggug                                                   20


<210>  17297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17297
gauguguuuu cugugaggau                                                   20


<210>  17298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17298
cagaaaacac aucagagacc                                                   20


<210>  17299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17299
uccuggaauc accuguuuuu                                                   20


<210>  17300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17300
uuccaagggu uucccugacu                                                   20


<210>  17301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17301
uucugaagcc accacuaauc                                                   20


<210>  17302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17302
cugcagcuca uucugaagcc                                                   20


<210>  17303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17303
ccgcagagag agugaugaau                                                   20


<210>  17304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17304
gcagagagag ugaugaaucc                                                   20


<210>  17305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17305
gcggagagca aggcagacac                                                   20


<210>  17306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17306
cugcggagag caaggcagac                                                   20


<210>  17307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17307
cucugcggag agcaaggcag                                                   20


<210>  17308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17308
ugagccucug uccaguuguu                                                   20


<210>  17309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17309
ugagaaggau ucaucacucu                                                   20


<210>  17310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17310
guccaguugu uccucccucc                                                   20


<210>  17311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17311
cuccaccugg aagggacccu                                                   20


<210>  17312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17312
accuggaagg gacccugggu                                                   20


<210>  17313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17313
uaacauccca gcggaacagg                                                   20


<210>  17314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17314
uccuccugcc ggcuuccugg                                                   20


<210>  17315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17315
ugccggcuuc cuggccccuc                                                   20


<210>  17316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17316
uaugucugcu uccugacgcc                                                   20


<210>  17317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17317
ggaauugaau uuugccuuug                                                   20


<210>  17318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17318
caccuguaau ccugugcacu                                                   20


<210>  17319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17319
agcaaucugc ccaccuuggc                                                   20


<210>  17320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17320
ugggcucaag caaucugccc                                                   20


<210>  17321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17321
aacuccuggg cucaagcaau                                                   20


<210>  17322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17322
ggcuaaucuc aaacuccugg                                                   20


<210>  17323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17323
cagcuacuca ggaaccugag                                                   20


<210>  17324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17324
ggaaccugag acaggaggau                                                   20


<210>  17325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17325
gguuccugag uagcugggag                                                   20


<210>  17326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17326
ugucucaggu uccugaguag                                                   20


<210>  17327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17327
auugauccuc cugucucagg                                                   20


<210>  17328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17328
ggggcucaau ugauccuccu                                                   20


<210>  17329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17329
agucugguca aacagaguga                                                   20


<210>  17330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17330
guuugaccag acuggaguac                                                   20


<210>  17331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17331
cucuguuuga ccagacugga                                                   20


<210>  17332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17332
uuuacacuua acagccacac                                                   20


<210>  17333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17333
ugcuuccuuc augagggguc                                                   20


<210>  17334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17334
ugaaggaagc aggagggcac                                                   20


<210>  17335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17335
cucuguguac acuccauucu                                                   20


<210>  17336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17336
guguacacuc cauucucauu                                                   20


<210>  17337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17337
auucucauug cccauggugg                                                   20


<210>  17338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17338
uugcccaugg ugguuuguuu                                                   20


<210>  17339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17339
uguuucucaa gccauggcag                                                   20


<210>  17340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17340
agccauggca gccugccucu                                                   20


<210>  17341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17341
ugcccucuuu acuaaaaagg                                                   20


<210>  17342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17342
uuacuaaaaa ggccuuugca                                                   20


<210>  17343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17343
gcaaaggccu uuuuaguaaa                                                   20


<210>  17344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17344
cucauccuag gcccuccagc                                                   20


<210>  17345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17345
cauccuaggc ccuccagcuu                                                   20


<210>  17346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17346
uccuaggccc uccagcuuga                                                   20


<210>  17347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17347
agcuugauuc uguggagcug                                                   20


<210>  17348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17348
acagaaucaa gcuggagggc                                                   20


<210>  17349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17349
ugucacucag uagcuugugg                                                   20


<210>  17350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17350
guagcuugug gggucuucuc                                                   20


<210>  17351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17351
gucuagccac uuaauugauu                                                   20


<210>  17352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17352
aguugcuguc cauggucucu                                                   20


<210>  17353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17353
aggaacacaa ucaauuaagu                                                   20


<210>  17354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17354
cguuacuguu uucucugugu                                                   20


<210>  17355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17355
uuacuguuuu cucuguguuu                                                   20


<210>  17356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17356
guguuucugc cucucuccuu                                                   20


<210>  17357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17357
cuccuuggcc uugguagguc                                                   20


<210>  17358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17358
ccuuggccuu gguaggucca                                                   20


<210>  17359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17359
uuggccuugg uagguccauc                                                   20


<210>  17360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17360
cauggacaac uuucucuugc                                                   20


<210>  17361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17361
uggacaacuu ucucuugcug                                                   20


<210>  17362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17362
ugcugguccu uguaguccug                                                   20


<210>  17363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17363
acacgggacu uguccugcca                                                   20


<210>  17364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17364
gacuugcacu uaaaauugaa                                                   20


<210>  17365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17365
ccagggccuc uucuuguuaa                                                   20


<210>  17366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17366
agggccucuu cuuguuaauu                                                   20


<210>  17367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17367
ucuuguuaau uagaucauua                                                   20


<210>  17368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17368
ucccgcuacc ccaggaaccc                                                   20


<210>  17369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17369
cgcuacccca ggaacccuaa                                                   20


<210>  17370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17370
uccucucuau cuacuaggag                                                   20


<210>  17371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17371
ucucuaucua cuaggaggug                                                   20


<210>  17372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17372
cuaucuacua ggagguggcc                                                   20


<210>  17373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17373
aucuacuagg agguggcccu                                                   20


<210>  17374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17374
uaguagauag agaggaggag                                                   20


<210>  17375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17375
gaguccgucu caucuuccac                                                   20


<210>  17376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17376
gagggccacc uccuaguaga                                                   20


<210>  17377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17377
ucuuccaccu gaacuucccu                                                   20


<210>  17378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17378
agcagcugcc accccggggg                                                   20


<210>  17379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17379
gcccccgggg uggcagcugc                                                   20


<210>  17380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17380
augccuugug cagugcugag                                                   20


<210>  17381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17381
gcacugcaca aggcauggag                                                   20


<210>  17382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17382
uguuugcucc uuauuacagc                                                   20


<210>  17383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17383
uuauuacagc ccugcgaaca                                                   20


<210>  17384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17384
uaauuccauc uuacaccuaa                                                   20


<210>  17385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17385
gcuuccuuag guguaagaug                                                   20


<210>  17386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17386
acugucuacu accuggguga                                                   20


<210>  17387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17387
gaaucagacu gccugguuca                                                   20


<210>  17388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17388
gccaccuaga acacagcuug                                                   20


<210>  17389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17389
guggccuggc ugcaucuucc                                                   20


<210>  17390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17390
ucacucaggg ggcccaugca                                                   20


<210>  17391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17391
gggggcccau gcaggaacag                                                   20


<210>  17392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17392
guuccugcau gggcccccug                                                   20


<210>  17393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17393
uccuucugug gggcccucug                                                   20


<210>  17394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17394
agcccauucu gcacuggccu                                                   20


<210>  17395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17395
acacuugcuu ccuggucagc                                                   20


<210>  17396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17396
agguuuccug ggauuucucu                                                   20


<210>  17397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17397
uccagguuuc cugggauuuc                                                   20


<210>  17398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17398
ggcuccucca gguuuccugg                                                   20


<210>  17399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17399
ucgucgugac cuggucugca                                                   20


<210>  17400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17400
ucgugaccug gucugcauuc                                                   20


<210>  17401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17401
gagugugcug cuucuguuag                                                   20


<210>  17402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17402
gagaaugcag accaggucac                                                   20


<210>  17403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17403
cuuccuuggu cucagguuau                                                   20


<210>  17404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17404
gguuauaguu uaaggcauug                                                   20


<210>  17405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17405
acaaugccuu aaacuauaac                                                   20


<210>  17406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17406
guuuuuaccu guuuuaggac                                                   20


<210>  17407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17407
aaaaaaaaaa aaaaaaaaaa                                                   20


<210>  17408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17408
aucucaaaaa aaaaaaaaaa                                                   20


<210>  17409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17409
cuccauugcc caggcuagag                                                   20


<210>  17410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17410
auugcccagg cuagagugca                                                   20


<210>  17411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17411
agccugggca auggagcgag                                                   20


<210>  17412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17412
uggguucaag caauucuugu                                                   20


<210>  17413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17413
cgccucccaa auaccuggga                                                   20


<210>  17414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17414
caaauaccug ggauuacagg                                                   20


<210>  17415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17415
gccaauuuuu guauuuuuag                                                   20


<210>  17416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17416
acuaaaaaua caaaaauugg                                                   20


<210>  17417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17417
aacuccugac cucaagugau                                                   20


<210>  17418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17418
ugaccucaag ugaucugccc                                                   20


<210>  17419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17419
agugaucugc ccaccuuggc                                                   20


<210>  17420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17420
caaagugcug ugauuauagg                                                   20


<210>  17421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17421
cgccuauaau cacagcacuu                                                   20


<210>  17422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17422
cccagaucug ggcugccugg                                                   20


<210>  17423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17423
cccccagauc ugggcugccu                                                   20


<210>  17424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17424
guuucccaag ucuugcugcc                                                   20


<210>  17425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17425
cccugcuggg cuuugcagcc                                                   20


<210>  17426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17426
cugcugggcu uugcagccug                                                   20


<210>  17427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17427
gugccuuuga ccuuguuuau                                                   20


<210>  17428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17428
uuuggauaaa caaggucaaa                                                   20


<210>  17429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17429
ccuuuggaua aacaagguca                                                   20


<210>  17430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17430
aggaaucaug acuucauucu                                                   20


<210>  17431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17431
gggcuccagg aaucaugacu                                                   20


<210>  17432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17432
acagcauccu ucucagggcu                                                   20


<210>  17433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17433
gcuagauucu accggcaaau                                                   20


<210>  17434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17434
gcaacacacu cagcuagauu                                                   20


<210>  17435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17435
ccacacacaa ugcuggcacc                                                   20


<210>  17436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17436
auggccgggc acagaggcca                                                   20


<210>  17437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17437
gugcccggcc auggagcauc                                                   20


<210>  17438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17438
ugacaccuga cagccaagug                                                   20


<210>  17439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17439
gcaggcuccu gacaccugac                                                   20


<210>  17440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17440
gugugcccuc ugcaggcucc                                                   20


<210>  17441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17441
ccuggccucc uucagcauuu                                                   20


<210>  17442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17442
uucagcauuu cugucccuca                                                   20


<210>  17443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17443
guccuuagca agcccaggag                                                   20


<210>  17444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17444
ugggcuugcu aaggacugag                                                   20


<210>  17445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17445
acagcuccug ggcuugcuaa                                                   20


<210>  17446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17446
gcaccugcca aacucaacag                                                   20


<210>  17447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17447
guccuguggg ggccccgcug                                                   20


<210>  17448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17448
ggccacagcg gggcccccac                                                   20


<210>  17449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17449
aaucacugca cucgggccac                                                   20


<210>  17450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17450
gcgccucgaa ucacugcacu                                                   20


<210>  17451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17451
uucuccagga gcuguguuca                                                   20


<210>  17452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17452
aggagcugug uucagacuuu                                                   20


<210>  17453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17453
uggagaagga gucagggaac                                                   20


<210>  17454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17454
uggcuuggag cuccuggagg                                                   20


<210>  17455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17455
aagccaagag cugcgaaagu                                                   20


<210>  17456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17456
uggagggcuu ggcauugccg                                                   20


<210>  17457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17457
aggagcucca agccaagagc                                                   20


<210>  17458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17458
acauuggucg gcaaugccaa                                                   20


<210>  17459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17459
cugucgaccu ccacauuggu                                                   20


<210>  17460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17460
cacugucgac cuccacauug                                                   20


<210>  17461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17461
cucacugucg accuccacau                                                   20


<210>  17462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17462
ucucucacug ucgaccucca                                                   20


<210>  17463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17463
cgccuuaauc ccagcacuuu                                                   20


<210>  17464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17464
caaagugcug ggauuaaggc                                                   20


<210>  17465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17465
gccucccaaa gugcugggau                                                   20


<210>  17466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17466
ugauccaccc gccucagccu                                                   20


<210>  17467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17467
ggaguucaag accagccugg                                                   20


<210>  17468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17468
ugagcucgug auccacccgc                                                   20


<210>  17469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17469
auacuaaaaa uacaaauauu                                                   20


<210>  17470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17470
caaguagcua ggauuacagg                                                   20


<210>  17471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17471
gccucccaag uagcuaggau                                                   20


<210>  17472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17472
ugccucagcc ucccaaguag                                                   20


<210>  17473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17473
accuuccggu uucaagcugu                                                   20


<210>  17474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17474
cugcaaacuc caccuuccgg                                                   20


<210>  17475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17475
aaccugggca acaagagcaa                                                   20


<210>  17476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17476
uguugcccag guuggagugc                                                   20


<210>  17477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17477
aucucaaaaa aaaaaaaaaa                                                   20


<210>  17478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17478
aaaaaaaaaa aaaaaguagg                                                   20


<210>  17479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17479
cauacuuacg uauucagaac                                                   20


<210>  17480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17480
gccuguuuca uuuuuaugua                                                   20


<210>  17481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17481
guccagugcc acauggcuac                                                   20


<210>  17482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17482
uuaacuuugu uucuaggaau                                                   20


<210>  17483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17483
ggaacauucc uagaaacaaa                                                   20


<210>  17484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17484
uuccaugauc accacccacc                                                   20


<210>  17485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17485
ggugucagau acugcugcuu                                                   20


<210>  17486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17486
ggacagggug cugggcuggc                                                   20


<210>  17487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17487
caguaaccug agcuuuggcc                                                   20


<210>  17488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17488
gguuacuggg agucucagga                                                   20


<210>  17489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17489
caaaaaaugg aaaaugaaaa                                                   20


<210>  17490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17490
guggcuccua cuaaguucua                                                   20


<210>  17491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17491
uacuaaguuc uaguccuuaa                                                   20


<210>  17492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17492
uuauaaagua aaugugguuc                                                   20


<210>  17493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17493
uggaaauguu auuuuaccau                                                   20


<210>  17494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17494
uuaugggugg cccucuuuuu                                                   20


<210>  17495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17495
uuuugcaaaa gguuuucagg                                                   20


<210>  17496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17496
auuucuaggu gcuccaacac                                                   20


<210>  17497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17497
aacacuccau uauuuguaua                                                   20


<210>  17498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17498
auuauuugua uauguaugga                                                   20


<210>  17499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17499
gcacaguauu ucuggaaggc                                                   20


<210>  17500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17500
agaucccacg cuggggaaaa                                                   20


<210>  17501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17501
agaacuucuu uuccccagcg                                                   20


<210>  17502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17502
uuugucucca gaacuucuuu                                                   20


<210>  17503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17503
cugcucagua uggauacugg                                                   20


<210>  17504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17504
gcucaguaug gauacuggac                                                   20


<210>  17505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17505
guauggauac uggaccuugu                                                   20


<210>  17506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17506
caguagggcc aguucauggc                                                   20


<210>  17507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17507
gcuggaaagu ccacuguugg                                                   20


<210>  17508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17508
caacagugga cuuuccagcu                                                   20


<210>  17509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17509
gugccguaug uagugggguc                                                   20


<210>  17510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17510
aacagaauga ccagacccca                                                   20


<210>  17511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17511
uccaacagaa ugaccagacc                                                   20


<210>  17512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17512
gucaucguaa caggccuaag                                                   20


<210>  17513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17513
ugcccccaca gugcucaguc                                                   20


<210>  17514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17514
uaguucugug cugcuuuaac                                                   20


<210>  17515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17515
uuuucugaca gaugggccug                                                   20


<210>  17516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17516
gauguuauau cagaaagcuc                                                   20


<210>  17517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17517
gaaucuggga auuguguccc                                                   20


<210>  17518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17518
aauucagggg acacaauucc                                                   20


<210>  17519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17519
ucaucuaagc auuucuguua                                                   20


<210>  17520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17520
gagggcaaac uacagcuuuu                                                   20


<210>  17521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17521
gagggcugaa ugaagacgcu                                                   20


<210>  17522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17522
gauccaguuu uccuuuauaa                                                   20


<210>  17523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17523
ugccuauaau cccagcaccu                                                   20


<210>  17524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17524
ggugaucugc ccgccuuggc                                                   20


<210>  17525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17525
aaguccuggc cucaggugau                                                   20


<210>  17526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17526
acugaaaaua acaaaaauua                                                   20


<210>  17527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17527
gcuaauuuuu guuauuuuca                                                   20


<210>  17528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17528
gaaggcugag gcgggagaau                                                   20


<210>  17529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17529
gccuucugag uagcagggac                                                   20


<210>  17530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17530
cgccucagcc uucugaguag                                                   20


<210>  17531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17531
uagguucaag cgauucuccc                                                   20


<210>  17532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17532
cugcaaccuu uuccuccuag                                                   20


<210>  17533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17533
gcucacugca accuuuuccu                                                   20


<210>  17534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17534
agccugggug acagagugag                                                   20


<210>  17535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17535
gucacccagg cuagagugca                                                   20


<210>  17536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17536
cucugucacc caggcuagag                                                   20


<210>  17537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17537
aucucaaaaa aaaaaaaaaa                                                   20


<210>  17538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17538
aaaaaaaaaa aaaaaaaaaa                                                   20


<210>  17539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17539
caugcuuguu acauauuauc                                                   20


<210>  17540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17540
augggcaucu uggacacuua                                                   20


<210>  17541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17541
cuaugggcau cuuggacacu                                                   20


<210>  17542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17542
gcucucuaug ggcaucuugg                                                   20


<210>  17543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17543
uagcacugug uuuuuccagc                                                   20


<210>  17544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17544
ucccccacca cccacagcug                                                   20


<210>  17545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17545
uggaaauaaa aagauacuca                                                   20


<210>  17546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17546
ucucauggaa auaaaaagau                                                   20


<210>  17547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17547
uuuuuuagcc auagacucag                                                   20


<210>  17548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17548
gcagccauaa aauugcugua                                                   20


<210>  17549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17549
ugacccucuc ucgguuugug                                                   20


<210>  17550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17550
cucgguuugu gugcaucucc                                                   20


<210>  17551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17551
cgguuugugu gcaucuccuc                                                   20


<210>  17552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17552
guuugugugc aucuccucuc                                                   20


<210>  17553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17553
ucucaggcug gcucccagau                                                   20


<210>  17554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17554
caggcuggcu cccagauggg                                                   20


<210>  17555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17555
ggcuggcucc cagaugggag                                                   20


<210>  17556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17556
cagaugggag cuggcuccag                                                   20


<210>  17557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17557
caucugggag ccagccugag                                                   20


<210>  17558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17558
aggcgacacu gggugcucug                                                   20


<210>  17559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17559
gcuccaggag guccuuaugu                                                   20


<210>  17560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17560
aggagguccu uauguggguc                                                   20


<210>  17561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17561
uggagcagag cacccagugu                                                   20


<210>  17562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17562
cuuauggacu cugucacugu                                                   20


<210>  17563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17563
uauggacucu gucacugugg                                                   20


<210>  17564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17564
gucacugugg guuuaugauu                                                   20


<210>  17565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17565
caaucugucu uaccucuugg                                                   20


<210>  17566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17566
aucugucuua ccucuuggug                                                   20


<210>  17567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17567
uggugaacug uuagaguccu                                                   20


<210>  17568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17568
aacaguucac caagagguaa                                                   20


<210>  17569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17569
ucuuguucug agucacccua                                                   20


<210>  17570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17570
gaacaagaug agcugggaag                                                   20


<210>  17571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17571
ggccauacac cgcccgguac                                                   20


<210>  17572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17572
aauucagccc caauuuguag                                                   20


<210>  17573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17573
uauuugaauu gcaaauacug                                                   20


<210>  17574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17574
ucucuuucag aggcucauua                                                   20


<210>  17575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17575
uucagaggcu cauuacccua                                                   20


<210>  17576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17576
gaaagagaag aggcaguauu                                                   20


<210>  17577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17577
uuacccuaua gcuguauuau                                                   20


<210>  17578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17578
agcuguaauu gugcacuuug                                                   20


<210>  17579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17579
gugggccguc cugccagcgc                                                   20


<210>  17580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17580
cccaaccaca ucaagauaua                                                   20


<210>  17581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17581
auaucuugau gugguugggg                                                   20


<210>  17582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17582
ucuauaucuu gaugugguug                                                   20


<210>  17583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17583
uccucugcca cauccugccc                                                   20


<210>  17584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17584
gccacauccu gccccucccc                                                   20


<210>  17585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17585
ccaggucuaa ccaccaaucc                                                   20


<210>  17586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17586
gucccucugu ucagcccauu                                                   20


<210>  17587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17587
guucagccca uugcagaagg                                                   20


<210>  17588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17588
ugccuguaau cccaguauuu                                                   20


<210>  17589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17589
aaauacuggg auuacaggca                                                   20


<210>  17590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17590
caaaauacug ggauuacagg                                                   20


<210>  17591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17591
cacuucagcc ucucaaaaua                                                   20


<210>  17592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17592
agucauccuc ccacuucagc                                                   20


<210>  17593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17593
cagccucaag ucauccuccc                                                   20


<210>  17594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17594
agaaaaaaaa aauuuaaaaa                                                   20


<210>  17595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17595
caagcagcug aacuacaggg                                                   20


<210>  17596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17596
gccucccaag cagcugaacu                                                   20


<210>  17597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17597
ugccucagcc ucccaagcag                                                   20


<210>  17598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17598
agugauccuc cugccucagc                                                   20


<210>  17599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17599
ggaguuagag guuacaguga                                                   20


<210>  17600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17600
ugagcucaag ugauccuccu                                                   20


<210>  17601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17601
aacuccugag cucaagugau                                                   20


<210>  17602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17602
cuguaaccuc uaacuccuga                                                   20


<210>  17603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17603
agccuaggug acacagcaag                                                   20


<210>  17604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17604
ggggaaaaaa gaaagaaacg                                                   20


<210>  17605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17605
gaaggcugca caccgcgugg                                                   20


<210>  17606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17606
ccgaaagggg ccagacucag                                                   20


<210>  17607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17607
cuccuugcaa cugcugagca                                                   20


<210>  17608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17608
uugcaacugc ugagcauugu                                                   20


<210>  17609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17609
gcaguugcaa ggagcgagcc                                                   20


<210>  17610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17610
guuucccaac uggugaagug                                                   20


<210>  17611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17611
ucuaaauccu gagggauuac                                                   20


<210>  17612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17612
ggauuuagaa gagaacuggu                                                   20


<210>  17613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17613
guccccguua aggcccuuug                                                   20


<210>  17614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17614
gucagacccu gaaggucaga                                                   20


<210>  17615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17615
gaccuucagg gucugaccga                                                   20


<210>  17616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17616
caaacugccc cucugaccuu                                                   20


<210>  17617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17617
aguccauaca guuaaaaugu                                                   20


<210>  17618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17618
uggcucuagu ccauacaguu                                                   20


<210>  17619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17619
agguuuauaa uucccacgua                                                   20


<210>  17620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17620
cuuuauuguu uuuuucuuuu                                                   20


<210>  17621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17621
acacugacuu cucacuuuau                                                   20


<210>  17622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17622
aaacauguug auguuauacg                                                   20


<210>  17623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17623
cugcuuucau guuuuacugu                                                   20


<210>  17624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17624
aucugccgug aaaguugcca                                                   20


<210>  17625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17625
auuaucaaac auagccagug                                                   20


<210>  17626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17626
cacuggcuau guuugauaau                                                   20


<210>  17627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17627
guuaucuauu ccuaagcuac                                                   20


<210>  17628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17628
caguuaucua uuccuaagcu                                                   20


<210>  17629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17629
cugccaucca gaaacauugu                                                   20


<210>  17630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17630
uucuagaaga cacagucugu                                                   20


<210>  17631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17631
agacaucugg ggacuaagua                                                   20


<210>  17632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17632
ucuccagaca ucuggggacu                                                   20


<210>  17633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17633
ucuucuccag acaucugggg                                                   20


<210>  17634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17634
auugcacauu ccaaguuugg                                                   20


<210>  17635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17635
ucguacuauu ucucuauugc                                                   20


<210>  17636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17636
cauucucuuc ugugauuaug                                                   20


<210>  17637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17637
uucucuucug ugauuauguc                                                   20


<210>  17638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17638
ucugugauua ugucguaagu                                                   20


<210>  17639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17639
accccguuua caggcauuuc                                                   20


<210>  17640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17640
cucaaccccg uuuacaggca                                                   20


<210>  17641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17641
ugguccccac cucccucaac                                                   20


<210>  17642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17642
ggaacccaga ccgcccggug                                                   20


<210>  17643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17643
aucgaaacua aaucuagaau                                                   20


<210>  17644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17644
aauuauaugu cacagcagaa                                                   20


<210>  17645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17645
caguccaacu uagaauccag                                                   20


<210>  17646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17646
cacaguccaa cuuagaaucc                                                   20


<210>  17647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17647
uuuaucaaau gcccggcuau                                                   20


<210>  17648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17648
cgccuacaug augcugggua                                                   20


<210>  17649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17649
aauuaacaaa cauacccagc                                                   20


<210>  17650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17650
ugguauuaau uuuuaaaaaa                                                   20


<210>  17651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17651
agaggcugag guaggaagau                                                   20


<210>  17652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17652
aguugcugga auuuaggcau                                                   20


<210>  17653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17653
cgaguugcug gaauuuaggc                                                   20


<210>  17654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17654
gccucucgag uugcuggaau                                                   20


<210>  17655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17655
agugaucuuc cuaccucagc                                                   20


<210>  17656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17656
ugggcucaag ugaucuuccu                                                   20


<210>  17657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17657
aacuccuggg cucaagugau                                                   20


<210>  17658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17658
caccauagcc caggcuuguc                                                   20


<210>  17659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17659
aaaaaaauaa aaaauaaaaa                                                   20


<210>  17660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17660
ugccuguaau cacagcucuu                                                   20


<210>  17661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17661
uugagaagcu gagggcggag                                                   20


<210>  17662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17662
aagagcugug auuacaggca                                                   20


<210>  17663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17663
gcuucucaaa gagcugugau                                                   20


<210>  17664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17664
gcccucagcu ucucaaagag                                                   20


<210>  17665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17665
agccauccuc cgcccucagc                                                   20


<210>  17666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17666
caggcucaag ccauccuccg                                                   20


<210>  17667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17667
aacucccagg cucaagccau                                                   20


<210>  17668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17668
guguugccag gcuggucucg                                                   20


<210>  17669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17669
accaaaaaaa gaaagagagg                                                   20


<210>  17670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17670
uucuuuuuuu gguagaggca                                                   20


<210>  17671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17671
cuuucuuuuu uugguagagg                                                   20


<210>  17672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17672
gguggcuggg accacaggca                                                   20


<210>  17673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17673
cagguggcug ggaccacagg                                                   20


<210>  17674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17674
gucucucagg uggcugggac                                                   20


<210>  17675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17675
cuucucaguc ucucaggugg                                                   20


<210>  17676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17676
agcaauccuc ccuucucagu                                                   20


<210>  17677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17677
aacuucuggg cucaagcaau                                                   20


<210>  17678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17678
cugcagccuc aaacuucugg                                                   20


<210>  17679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17679
ggccugggug acaaggcgag                                                   20


<210>  17680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17680
ccuugucacc caggccggag                                                   20


<210>  17681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17681
aaaauaauuu uuuuaaguua                                                   20


<210>  17682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17682
uuaaagaaaa aaaaauaacu                                                   20


<210>  17683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17683
cacaaguuau uuuuuuuucu                                                   20


<210>  17684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17684
augguaaaua ugugaugcua                                                   20


<210>  17685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17685
guuuauuugu uuuuuuguaa                                                   20


<210>  17686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17686
uguaaucaua cuacucagag                                                   20


<210>  17687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17687
gagauaacuu gcuguuagau                                                   20


<210>  17688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17688
gaguaguaug auuacaggag                                                   20


<210>  17689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17689
ccaacugaaa gagguguuau                                                   20


<210>  17690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17690
aacugaaaga gguguuaucc                                                   20


<210>  17691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17691
uucaguugga gagucggcuu                                                   20


<210>  17692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17692
aggauaacac cucuuucagu                                                   20


<210>  17693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17693
auugaaguag uuuuucuauu                                                   20


<210>  17694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17694
aaauucugaa gcuuuuugag                                                   20


<210>  17695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17695
aaaagcuuca gaauuuggag                                                   20


<210>  17696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17696
cuaaauccga aaaucugaaa                                                   20


<210>  17697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17697
acaaauaagu auaaugcaca                                                   20


<210>  17698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17698
gcauguuuaa aaauauauau                                                   20


<210>  17699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17699
uuuuccaauu uugugauagu                                                   20


<210>  17700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17700
aauuacucuu uuuccaauuu                                                   20


<210>  17701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17701
cgggcuucgg gccggcuaag                                                   20


<210>  17702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17702
cccgggcuuc gggccggcua                                                   20


<210>  17703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17703
cugaggccug ccuuuguccu                                                   20


<210>  17704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17704
gcgagauccg cagguagcag                                                   20


<210>  17705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17705
gagagcugga cugcuguacc                                                   20


<210>  17706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17706
gagacacuaa caaauggcca                                                   20


<210>  17707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17707
cagagacacu aacaaauggc                                                   20


<210>  17708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17708
gccgcagugc gugguuggag                                                   20


<210>  17709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17709
aaccacgcac ugcggcagag                                                   20


<210>  17710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17710
auuuaccaag gccgucaccu                                                   20


<210>  17711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17711
ucaauuauuu gugcucauac                                                   20


<210>  17712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17712
auuauuugug cucauacacu                                                   20


<210>  17713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17713
uacacuguau auuuuuagug                                                   20


<210>  17714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17714
cuaaaaauau acaguguaug                                                   20


<210>  17715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17715
uucuuacccu uucuggccuu                                                   20


<210>  17716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17716
ucuuguguac uugaaaauga                                                   20


<210>  17717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17717
caucauauuu uuccuuagug                                                   20


<210>  17718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17718
ucauauuuuu ccuuaguguc                                                   20


<210>  17719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17719
augacuccga gcacuuaacg                                                   20


<210>  17720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17720
gagcacuuaa cguggcucau                                                   20


<210>  17721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17721
gagucaugga gguucugaca                                                   20


<210>  17722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17722
uuguaaauca cauucaagau                                                   20


<210>  17723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17723
ugggaaaggc ugaucagauc                                                   20


<210>  17724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17724
aguacaggac uucaucagug                                                   20


<210>  17725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17725
gcugccagcg gccuguucau                                                   20


<210>  17726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17726
uugugaaaac cuuucaacug                                                   20


<210>  17727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17727
auuuuuaagg cagggaaaac                                                   20


<210>  17728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17728
ucagugcuug gaggggaucc                                                   20


<210>  17729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17729
aagcacugaa gaguuuucuu                                                   20


<210>  17730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17730
gccagucggg agcugugcuc                                                   20


<210>  17731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17731
cgacuggcug agauggaucc                                                   20


<210>  17732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17732
cgcuguaugu ggacaggcuu                                                   20


<210>  17733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17733
cauggucgac auccuugcuu                                                   20


<210>  17734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17734
ucccaauacc uguaaauuug                                                   20


<210>  17735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17735
guaaguaugg ucuugacaug                                                   20


<210>  17736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17736
uguguccgau cugacuguuu                                                   20


<210>  17737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17737
uuuaaaaagg augaacugau                                                   20


<210>  17738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17738
ugcucauuua aaaaggauga                                                   20


<210>  17739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17739
aauagacaaa aacacauuag                                                   20


<210>  17740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17740
acagaaucca ggaauaccuu                                                   20


<210>  17741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17741
gaagguauuc cuggauucug                                                   20


<210>  17742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17742
cucagaggua augcuggaaa                                                   20


<210>  17743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17743
gagguaaugc uggaaacaca                                                   20


<210>  17744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17744
gagcgagccc gcugcucuga                                                   20


<210>  17745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17745
cuuucuaaag aguaaaggau                                                   20


<210>  17746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17746
uuagaaagug agaucugguu                                                   20


<210>  17747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17747
cgucacagac gugauccugc                                                   20


<210>  17748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17748
acucacguca cagacgugau                                                   20


<210>  17749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17749
ugguggcugu uugagaggua                                                   20


<210>  17750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17750
aacagccacc aggagugcaa                                                   20


<210>  17751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17751
caaacagcca ccaggagugc                                                   20


<210>  17752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17752
ucacaggaca gugaauacag                                                   20


<210>  17753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17753
uguuuagcaa uuagaugaca                                                   20


<210>  17754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17754
gauuugccaa cucuuguuua                                                   20


<210>  17755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17755
cagauuugcc aacucuuguu                                                   20


<210>  17756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17756
auccuuggca ugcaggacuu                                                   20


<210>  17757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17757
aagacuuugc aaacacaacu                                                   20


<210>  17758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17758
uaugugagug uauuuccaug                                                   20


<210>  17759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17759
cauaggagau guagggauuu                                                   20


<210>  17760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17760
cacacacaau cccugccccc                                                   20


<210>  17761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17761
cacacacaca aucccugccc                                                   20


<210>  17762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17762
cucucacaca cacaaucccu                                                   20


<210>  17763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17763
cccucucaca cacacaaucc                                                   20


<210>  17764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17764
cucccucuca cacacacaau                                                   20


<210>  17765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17765
cucucccucu cacacacaca                                                   20


<210>  17766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17766
gcugucucuc ucucccucuc                                                   20


<210>  17767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17767
uucucugcug ucucucucuc                                                   20


<210>  17768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17768
aaguacacag caugauaauu                                                   20


<210>  17769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17769
aaagacugaa aagcauaaua                                                   20


<210>  17770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17770
aaagacugaa aagcauaaua                                                   20


<210>  17771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17771
uuuguaauuu gcauuaugaa                                                   20


<210>  17772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17772
cauagcagau ggcgggagau                                                   20


<210>  17773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17773
uagcagaugg cgggagauaa                                                   20


<210>  17774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17774
cgccaucugc uaugagagug                                                   20


<210>  17775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17775
ucuggacuga agacuaaguc                                                   20


<210>  17776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17776
cucaucugga cugaagacua                                                   20


<210>  17777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17777
ucuggcacaa gauauuuaua                                                   20


<210>  17778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17778
aaugcacaaa uuccacuauc                                                   20


<210>  17779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17779
aacacugcaa caggcaauac                                                   20


<210>  17780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17780
auuaauauuu uccagaaauu                                                   20


<210>  17781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17781
aacaggucau gauacaaaug                                                   20


<210>  17782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17782
ucaauacuca aacaggucau                                                   20


<210>  17783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17783
uuagagugua uauuucuaga                                                   20


<210>  17784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17784
aaggagaugc acuauuagug                                                   20


<210>  17785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17785
gcacacuagg auucuagaaa                                                   20


<210>  17786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17786
auucccugcu ggacagguuu                                                   20


<210>  17787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17787
ccaccaugca agacucacuu                                                   20


<210>  17788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17788
accaugcaag acucacuuag                                                   20


<210>  17789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17789
cuuagucccu cuccuccagu                                                   20


<210>  17790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17790
ccuccagucu cuucccaccc                                                   20


<210>  17791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17791
uccagucucu ucccacccgc                                                   20


<210>  17792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17792
agucucuucc cacccgcugg                                                   20


<210>  17793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17793
ucccacccgc uggacgggga                                                   20


<210>  17794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17794
cuguuuccag ugacacgugc                                                   20


<210>  17795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17795
caugcagaca cgcuggacac                                                   20


<210>  17796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17796
gcgcccugug ccucccaugc                                                   20


<210>  17797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17797
gucaccugug gcagauacag                                                   20


<210>  17798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17798
guaucugcca caggugacag                                                   20


<210>  17799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17799
cuguaucugc cacaggugac                                                   20


<210>  17800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17800
gcacucucug uaucugccac                                                   20


<210>  17801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17801
ucugcacucu cuguaucugc                                                   20


<210>  17802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17802
uuggguccac ggcaccuccu                                                   20


<210>  17803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17803
gcucggcuca gugaagcugu                                                   20


<210>  17804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17804
gcucagugaa gcugugguua                                                   20


<210>  17805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17805
gugaagcugu gguuagagac                                                   20


<210>  17806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17806
aaccacagcu ucacugagcc                                                   20


<210>  17807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17807
gaccuugaug gccccccacg                                                   20


<210>  17808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17808
cucagaccuu gauggccccc                                                   20


<210>  17809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17809
uaccaaaagg gucccacauc                                                   20


<210>  17810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17810
ccccacacuc cuaccaaaag                                                   20


<210>  17811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17811
cuccaucucc ucauaccuuc                                                   20


<210>  17812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17812
aucuccucau accuucuggc                                                   20


<210>  17813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17813
ucauaccuuc uggccaccug                                                   20


<210>  17814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17814
uaccuucugg ccaccuguga                                                   20


<210>  17815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17815
cagguggcca gaagguauga                                                   20


<210>  17816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17816
acugcucaua ccucaugguu                                                   20


<210>  17817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17817
uaccucaugg uuagggacca                                                   20


<210>  17818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17818
ugguuaggga ccaccuggag                                                   20


<210>  17819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17819
aggugguccc uaaccaugag                                                   20


<210>  17820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17820
accaaggcuc cagguggucc                                                   20


<210>  17821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17821
accaaggcuc uaccaaggcu                                                   20


<210>  17822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17822
acuuuccugg acaaaguuca                                                   20


<210>  17823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17823
auucgcuaag caccugcccu                                                   20


<210>  17824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17824
ccagcaacca gggcagggca                                                   20


<210>  17825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17825
ccccagcaac cagggcaggg                                                   20


<210>  17826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17826
ucucucccca gcaaccaggg                                                   20


<210>  17827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17827
uggguugucu gcuuuacuca                                                   20


<210>  17828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17828
ccuggguugu cugcuuuacu                                                   20


<210>  17829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17829
cccuucaccu ggugaacuuc                                                   20


<210>  17830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17830
cagccucccc cuucaccugg                                                   20


<210>  17831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17831
ccacaccaca gguuuucccc                                                   20


<210>  17832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17832
cagccuagug cgguguuccc                                                   20


<210>  17833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17833
gccuagugcg guguucccaa                                                   20


<210>  17834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17834
agggauguga aguccccuug                                                   20


<210>  17835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17835
gcaccuucca gcagugcaga                                                   20


<210>  17836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17836
guacgggggg agcaguggag                                                   20


<210>  17837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17837
ccccguaccg aguucaucau                                                   20


<210>  17838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17838
acugcucccc ccguaccgag                                                   20


<210>  17839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17839
gcuuuucuug ugacuuccaa                                                   20


<210>  17840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17840
ucaucaugug acccacuugu                                                   20


<210>  17841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17841
agucugggca gggacgggau                                                   20


<210>  17842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17842
gacaucccgu cccugcccag                                                   20


<210>  17843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17843
ccgacauccc gucccugccc                                                   20


<210>  17844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17844
acucugaaug gggccgggaa                                                   20


<210>  17845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17845
gaauggggcc gggaaguggg                                                   20


<210>  17846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17846
ccacuucccg gccccauuca                                                   20


<210>  17847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17847
auuucagaug gggucgggac                                                   20


<210>  17848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17848
aucagcauaa cccccauguc                                                   20


<210>  17849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17849
guggauucua auguggcuga                                                   20


<210>  17850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17850
ucccaaacca uacacccagc                                                   20


<210>  17851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17851
acuggaggaa caaacacagg                                                   20


<210>  17852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17852
aguggaggcc agauaguucu                                                   20


<210>  17853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17853
auggccaaga cagaauggaa                                                   20


<210>  17854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17854
uuuacgacua aagaucaacu                                                   20


<210>  17855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17855
cugcauccaa gggucucuuu                                                   20


<210>  17856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17856
acucacaccu cuguuagaug                                                   20


<210>  17857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17857
caccucuguu agauguagug                                                   20


<210>  17858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17858
guuagaugua gugagguucu                                                   20


<210>  17859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17859
cuacaucuaa cagaggugug                                                   20


<210>  17860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17860
gacaucuggg guuggggggu                                                   20


<210>  17861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17861
gcgcagggug cccucugaca                                                   20


<210>  17862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17862
uagcucugcg cagggugccc                                                   20


<210>  17863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17863
cccgugggca gguccuguga                                                   20


<210>  17864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17864
caggaccugc ccacggguga                                                   20


<210>  17865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17865
uggguauggu gcagccaugg                                                   20


<210>  17866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17866
gaccuacuag gacgggagaa                                                   20


<210>  17867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17867
cguccuagua ggucugagaa                                                   20


<210>  17868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17868
uggugcuuua gcccugcguu                                                   20


<210>  17869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17869
cauuugcugc auaucaacgc                                                   20


<210>  17870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17870
caggugccca cuucccuccc                                                   20


<210>  17871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17871
acaggcauuu guccucccag                                                   20


<210>  17872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17872
cggccucuac aggcauuugu                                                   20


<210>  17873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17873
uuucaugaac accugccguc                                                   20


<210>  17874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17874
ccacaagguc ucuuuucaug                                                   20


<210>  17875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17875
ucaguacauc agaacacacu                                                   20


<210>  17876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17876
acugaaaaca acaggagaau                                                   20


<210>  17877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17877
uguuguuuuc aguugagcuc                                                   20


<210>  17878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17878
aaaaaaaaaa aaaagauaaa                                                   20


<210>  17879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17879
cuguuguccc ccaggcugga                                                   20


<210>  17880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17880
agccuggggg acaacagcga                                                   20


<210>  17881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17881
cugcaaccuc cgccuccugg                                                   20


<210>  17882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17882
gccuccuggg uucauacgau                                                   20


<210>  17883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17883
uggguucaua cgauucuccu                                                   20


<210>  17884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17884
ugccucagcc ucccaaauag                                                   20


<210>  17885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17885
gccucccaaa uagcugguau                                                   20


<210>  17886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17886
caaauagcug guauuaacag                                                   20


<210>  17887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17887
acuaaaaaua caaaaauuag                                                   20


<210>  17888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17888
aacuccugac cucaggugau                                                   20


<210>  17889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17889
ugaccucagg ugauccgccc                                                   20


<210>  17890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17890
ggugauccgc ccaccucggc                                                   20


<210>  17891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17891
gccucccaaa gugcugggau                                                   20


<210>  17892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17892
caaagugcug ggauuauagg                                                   20


<210>  17893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17893
ggccuauaau cccagcacuu                                                   20


<210>  17894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17894
guaaguuagc uuucacugca                                                   20


<210>  17895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17895
gaaaagcauc augaaugcca                                                   20


<210>  17896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17896
gugauacacc aaccacccua                                                   20


<210>  17897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17897
uggauuugcu ugaaauaaaa                                                   20


<210>  17898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17898
uaguauuuua aguaauauuu                                                   20


<210>  17899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17899
cuuaguauuu uaaguaauau                                                   20


<210>  17900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17900
augccuguua uaaauauuug                                                   20


<210>  17901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17901
gaaacauuug ccuuauucuu                                                   20


<210>  17902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17902
uaaucuguug uuauuguuug                                                   20


<210>  17903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17903
gauuucagga guucaaccua                                                   20


<210>  17904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17904
ugaaaucaga gcauuaaagg                                                   20


<210>  17905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17905
augcuuaagc cuagggauga                                                   20


<210>  17906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17906
ucccuaggcu uaagcaugga                                                   20


<210>  17907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17907
ucuggccacc agaaauuuca                                                   20


<210>  17908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17908
cgggcugcuu caaaaagggc                                                   20


<210>  17909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17909
ggcccgugug agcggcaccg                                                   20


<210>  17910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17910
cacgggccag agucaccuca                                                   20


<210>  17911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17911
cugcugucca ucaugucuuc                                                   20


<210>  17912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17912
ggcuggaaga caugauggac                                                   20


<210>  17913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17913
gcaggcagcu cgggcuggaa                                                   20


<210>  17914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17914
aguaggccgc cggcucugca                                                   20


<210>  17915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17915
guaaacgcuu ucaauguauu                                                   20


<210>  17916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17916
uuagcuaccu cuguaaacgc                                                   20


<210>  17917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17917
gcucagaauu ucuuccugug                                                   20


<210>  17918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17918
gaauuucuuc cuguguguuu                                                   20


<210>  17919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17919
aagcccuuga ggaaggcugg                                                   20


<210>  17920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17920
agggcuuaga gcccuauguc                                                   20


<210>  17921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17921
ggggagaugc agccccaaac                                                   20


<210>  17922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17922
ccugaggucu ggcccagccu                                                   20


<210>  17923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17923
guggcacauc uacacauccg                                                   20


<210>  17924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17924
agacauuguu ccucaguggc                                                   20


<210>  17925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17925
gagaauugcu ugacugccuu                                                   20


<210>  17926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17926
gagaaucuga ugaaagcuca                                                   20


<210>  17927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17927
cguuugcacc cacccacgag                                                   20


<210>  17928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17928
ugggugggug caaacgugag                                                   20


<210>  17929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17929
ggcccgggcc cuggcacagu                                                   20


<210>  17930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17930
aaacugccca gucauuugca                                                   20


<210>  17931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17931
ugagaaagag aaggacauug                                                   20


<210>  17932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17932
ggaggaaggu gcaaaugacu                                                   20


<210>  17933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17933
uucucaggag gaaggugcaa                                                   20


<210>  17934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17934
aggguugcca ccacgaauuu                                                   20


<210>  17935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17935
uaccucaagg guugccacca                                                   20


<210>  17936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17936
ggagcucagu guugcugugg                                                   20


<210>  17937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17937
cgagcugccu cuuaccucaa                                                   20


<210>  17938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17938
guguugcugu ggggaggggg                                                   20


<210>  17939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17939
ccacagcaac acugagcucc                                                   20


<210>  17940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17940
ucagugucag ccccaugccc                                                   20


<210>  17941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17941
gaccagucca gucacuuuuc                                                   20


<210>  17942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17942
gccuggcagu aagucuuguc                                                   20


<210>  17943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17943
ccucgccacu ccucauggug                                                   20


<210>  17944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17944
ccacuccuca ugguggccug                                                   20


<210>  17945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17945
ucaugguggc cugugagguc                                                   20


<210>  17946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17946
ugguggccug ugaggucagc                                                   20


<210>  17947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17947
caggccacca ugaggagugg                                                   20


<210>  17948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17948
ucugcaccua ccauguuagg                                                   20


<210>  17949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17949
aaaauuagga uccaccuaac                                                   20


<210>  17950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17950
gcaaggacac acuuugcaga                                                   20


<210>  17951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17951
gugggucugc aaaguguguc                                                   20


<210>  17952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17952
gccuccaccu cacaccaaag                                                   20


<210>  17953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17953
accucacacc aaagaaaggg                                                   20


<210>  17954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17954
caccaaagaa agggaggagu                                                   20


<210>  17955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17955
cuuucuuugg ugugaggugg                                                   20


<210>  17956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17956
ucccuuucuu uggugugagg                                                   20


<210>  17957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17957
caaaaugaua aauacacccu                                                   20


<210>  17958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17958
acgugguuca gaauaagggu                                                   20


<210>  17959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17959
cacaaccccc ugugagauag                                                   20


<210>  17960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17960
caacccccug ugagauaggc                                                   20


<210>  17961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17961
caggggguug ugagagucaa                                                   20


<210>  17962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17962
guuacuccca uuugacaggu                                                   20


<210>  17963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17963
cauuugacag gugaggaaag                                                   20


<210>  17964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17964
ccugucaaau gggaguaaca                                                   20


<210>  17965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17965
aagccuugcu uuccucaccu                                                   20


<210>  17966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17966
gagcuaggaa guagccauuc                                                   20


<210>  17967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17967
gaggaccugg gcaagucacu                                                   20


<210>  17968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17968
caaauucaac cuaugacaga                                                   20


<210>  17969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17969
aauucaaccu augacagagg                                                   20


<210>  17970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17970
gucauagguu gaauuugaga                                                   20


<210>  17971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17971
cacagcacca gggcuugccu                                                   20


<210>  17972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17972
uccuuggggc ucccacagca                                                   20


<210>  17973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17973
ggccuggugg ccacguagcc                                                   20


<210>  17974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17974
ugggcuacgu ggccaccagg                                                   20


<210>  17975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17975
ccugggcuac guggccacca                                                   20


<210>  17976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17976
uguagaaauc ucuccugggc                                                   20


<210>  17977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17977
uucagcgcug ugggcuccug                                                   20


<210>  17978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17978
ccuucagcgc ugugggcucc                                                   20


<210>  17979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17979
cuccuucagc gcugugggcu                                                   20


<210>  17980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17980
cucuccuuca gcgcuguggg                                                   20


<210>  17981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17981
gcugccucuc ucuccuucag                                                   20


<210>  17982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17982
gccacaaagc ccccuuacuc                                                   20


<210>  17983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17983
cugccacaaa gcccccuuac                                                   20


<210>  17984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17984
auuacauuca guccugaccc                                                   20


<210>  17985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17985
gacauggcuc cauuacauuc                                                   20


<210>  17986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17986
gugcuuugga cgguuccaca                                                   20


<210>  17987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17987
uguaccuucg uuuggggaag                                                   20


<210>  17988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17988
guacuucccu uuaggcccug                                                   20


<210>  17989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17989
uggaucaaau gccaggacag                                                   20


<210>  17990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17990
gcgggaucug cucauggauc                                                   20


<210>  17991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17991
aggcagggcu ggacugcugc                                                   20


<210>  17992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17992
ggagcguggu cuccuccaca                                                   20


<210>  17993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17993
agaggccagg cagcugcagg                                                   20


<210>  17994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17994
uccacagagu uugugaccca                                                   20


<210>  17995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17995
acagaguuug ugacccacgc                                                   20


<210>  17996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17996
guggaggaga ccacgcucca                                                   20


<210>  17997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17997
cucaucuacu gugugcacuu                                                   20


<210>  17998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17998
ucuacugugu gcacuucauc                                                   20


<210>  17999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  17999
aggaugaagu gcacacagua                                                   20


<210>  18000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18000
ccggccucca ggaugaagug                                                   20


<210>  18001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18001
auccccaauu ccuagcuuag                                                   20


<210>  18002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18002
ccauccccaa uuccuagcuu                                                   20


<210>  18003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18003
uacucuccaa uauauuggag                                                   20


<210>  18004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18004
ccaauauauu ggagucuaca                                                   20


<210>  18005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18005
aauauauugg agucuacacu                                                   20


<210>  18006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18006
aauauauugg agaguaagag                                                   20


<210>  18007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18007
aaacuuuaug ucucugugau                                                   20


<210>  18008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18008
gugaucuuug gucuuagcug                                                   20


<210>  18009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18009
gacagaaaac aaauaaucuu                                                   20


<210>  18010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18010
acaaggguca uuagccacaa                                                   20


<210>  18011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18011
aacauguaaa cuaugacguc                                                   20


<210>  18012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18012
auaacauuua auuuaaaaau                                                   20


<210>  18013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18013
aagaagucug gcuuuuaagu                                                   20


<210>  18014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18014
agauacuauc aaaaucauca                                                   20


<210>  18015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18015
uaauaaccuc agggugagag                                                   20


<210>  18016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18016
gggugagaga uggccaacag                                                   20


<210>  18017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18017
cccugagguu auuaugagac                                                   20


<210>  18018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18018
cacccugagg uuauuaugag                                                   20


<210>  18019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18019
uguuggccau cucucacccu                                                   20


<210>  18020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18020
acugucuccu guuggccauc                                                   20


<210>  18021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18021
ugguuagugg uauaugucug                                                   20


<210>  18022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18022
gucuaguauu gucuguuugu                                                   20


<210>  18023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18023
caaaaguuga aagggauaga                                                   20


<210>  18024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18024
uuguucuguu guaauuuuag                                                   20


<210>  18025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18025
aggcugcacu gcaacuaaaa                                                   20


<210>  18026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18026
ccaggcugca cugcaacuaa                                                   20


<210>  18027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18027
cugauggcuu uugggguauu                                                   20


<210>  18028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18028
ucgcugaugg cuuuuggggu                                                   20


<210>  18029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18029
uccucgcuga uggcuuuugg                                                   20


<210>  18030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18030
uccuccucgc ugauggcuuu                                                   20


<210>  18031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18031
guguguuugg aucuacuucc                                                   20


<210>  18032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18032
ggacccauuu uuuucuuaca                                                   20


<210>  18033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18033
aggacuuaaa aaucauucac                                                   20


<210>  18034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18034
gugaaugauu uuuaaguccu                                                   20


<210>  18035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18035
ccgcggugca cgucucugug                                                   20


<210>  18036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18036
uggaagcgca ccguagcucc                                                   20


<210>  18037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18037
gcuguguccu gcugcuccuc                                                   20


<210>  18038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18038
ucccuagcug ucagggaggc                                                   20


<210>  18039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18039
cuagcuguca gggaggcugu                                                   20


<210>  18040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18040
cugacagcua gggaggagca                                                   20


<210>  18041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18041
uuuguuuccg agugaacacc                                                   20


<210>  18042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18042
gaaacaaaag agcuggcaaa                                                   20


<210>  18043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18043
gacccuacag accagcuggg                                                   20


<210>  18044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18044
cccaguggca ucccagcugg                                                   20


<210>  18045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18045
cuuccccccg cacuucccac                                                   20


<210>  18046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18046
gcaguuauuc ugagauccuu                                                   20


<210>  18047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18047
gaauaacugc agaguguggg                                                   20


<210>  18048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18048
aggaucucag aauaacugca                                                   20


<210>  18049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18049
gaaauuaaug cucggccucu                                                   20


<210>  18050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18050
gccucugguc agcaagcaac                                                   20


<210>  18051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18051
ggucagcaag caacaaccuu                                                   20


<210>  18052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18052
acaaaagguu guugcuugcu                                                   20


<210>  18053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18053
ugugggaaac auuuauuuau                                                   20


<210>  18054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18054
gugucagguu cagccaucug                                                   20


<210>  18055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18055
caauucuaga guagguauuu                                                   20


<210>  18056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18056
agaauuggga ggaaagugca                                                   20


<210>  18057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18057
caacaggcac ugccaccauu                                                   20


<210>  18058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18058
gugggacagg caacaggggc                                                   20


<210>  18059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18059
ccuggagccu guccacacau                                                   20


<210>  18060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18060
aggugaggca cccccaccuc                                                   20


<210>  18061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18061
agguaagcgu gcuguguaaa                                                   20


<210>  18062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18062
guggcucagg aaacacgccu                                                   20


<210>  18063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18063
ggaaacacgc cuuuucaauc                                                   20


<210>  18064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18064
ugauugaaaa ggcguguuuc                                                   20


<210>  18065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18065
ccgcuuuugu gcaauccugg                                                   20


<210>  18066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18066
auccacaacc aggauugcac                                                   20


<210>  18067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18067
ucugguuccc gguucaaggu                                                   20


<210>  18068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18068
aauuacaaaa ccuugaaccg                                                   20


<210>  18069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18069
gaauuuguau cucaaaccuc                                                   20


<210>  18070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18070
aaccucugug gguccuucag                                                   20


<210>  18071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18071
guggguccuu caggcuucag                                                   20


<210>  18072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18072
cuacucugca ucuuccagcc                                                   20


<210>  18073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18073
gcaucuucca gccgaguggc                                                   20


<210>  18074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18074
gcuggaagau gcagaguagg                                                   20


<210>  18075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18075
ggcuguggau ccugugcuuc                                                   20


<210>  18076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18076
ccacagaagc acaggaucca                                                   20


<210>  18077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18077
auguaaagca ccuggaacgg                                                   20


<210>  18078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18078
acaaaugcua ucaugauuuu                                                   20


<210>  18079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18079
acuguuuuaa agcaauggaa                                                   20


<210>  18080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18080
aaccgccaag augucucaac                                                   20


<210>  18081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18081
aacucaaacc gccaagaugu                                                   20


<210>  18082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18082
uuaggcaaga gugggaagcu                                                   20


<210>  18083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18083
ugccuaaaga gggccauggg                                                   20


<210>  18084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18084
auaggacguu acuucuuaaa                                                   20


<210>  18085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18085
cgccuguaau cccagcacuu                                                   20


<210>  18086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18086
caaagugcug ggauuacagg                                                   20


<210>  18087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18087
gccucccaaa gugcugggau                                                   20


<210>  18088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18088
ugauccgccc gccucggccu                                                   20


<210>  18089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18089
ugaccucgug auccgcccgc                                                   20


<210>  18090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18090
aucuccugac cucgugaucc                                                   20


<210>  18091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18091
acuaaaaaua caaaaaauua                                                   20


<210>  18092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18092
caaguagcug ggacuacagg                                                   20


<210>  18093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18093
gccucccaag uagcugggac                                                   20


<210>  18094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18094
ugccucagcc ucccaaguag                                                   20


<210>  18095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18095
cggguucacg ccauucuccu                                                   20


<210>  18096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18096
gccucccggg uucacgccau                                                   20


<210>  18097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18097
cugcaagcuc cgccucccgg                                                   20


<210>  18098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18098
gcucacugca agcuccgccu                                                   20


<210>  18099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18099
agccugggcg acagagcaag                                                   20


<210>  18100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18100
gucgcccagg cuggagugca                                                   20


<210>  18101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18101
gucucaaaaa aaaaaaaaaa                                                   20


<210>  18102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18102
aaaaaaaaaa aaaauauuaa                                                   20


<210>  18103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18103
uuagcguggg gcuuaauugc                                                   20


<210>  18104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18104
uuggacuuaa gcaauuaagc                                                   20


<210>  18105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18105
auccuaggaa guugcccaaa                                                   20


<210>  18106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18106
uggccugugg guaauagcca                                                   20


<210>  18107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18107
cugccucaac aaaucauauu                                                   20


<210>  18108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18108
acaaaucaua uuuuaguagg                                                   20


<210>  18109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18109
agacaccauu cuguggaucu                                                   20


<210>  18110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18110
caaggcagac gcuguggaca                                                   20


<210>  18111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18111
agcacucuga ccuaggaaag                                                   20


<210>  18112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18112
gaccuaggaa agccagugaa                                                   20


<210>  18113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18113
gcuaguauca aagggccaug                                                   20


<210>  18114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18114
caggaccugu gucugucccu                                                   20


<210>  18115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18115
ggucucccag gaccuguguc                                                   20


<210>  18116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18116
ucuuucucug gucucccagg                                                   20


<210>  18117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18117
gccccucguc uuucucuggu                                                   20


<210>  18118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18118
ucugccccuc gucuuucucu                                                   20


<210>  18119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18119
gacuuccuuu aggacaccuc                                                   20


<210>  18120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18120
gccucagacu uccuuuagga                                                   20


<210>  18121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18121
ucagccucag acuuccuuua                                                   20


<210>  18122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18122
gugauaaggc cagcagcagc                                                   20


<210>  18123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18123
cugugauaag gccagcagca                                                   20


<210>  18124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18124
ggcccacucu cugugauaag                                                   20


<210>  18125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18125
ggccuugguu cccagcccuc                                                   20


<210>  18126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18126
gguucaggac cauuccagca                                                   20


<210>  18127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18127
ccauuuucug cugggauugc                                                   20


<210>  18128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18128
gagucuaagu ggauuccaca                                                   20


<210>  18129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18129
gaguuggcca cugaaggccu                                                   20


<210>  18130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18130
agcuguaacu guggaaucca                                                   20


<210>  18131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18131
cuuaaccguu gcuuguuuag                                                   20


<210>  18132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18132
uaaccguugc uuguuuagau                                                   20


<210>  18133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18133
caggcugcag ugauauacuu                                                   20


<210>  18134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18134
accauuucug ccaccaucuc                                                   20


<210>  18135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18135
gcagucggug uuggccuugg                                                   20


<210>  18136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18136
cgccauugcu aaggaacauc                                                   20


<210>  18137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18137
ccaguggggg cacacgugug                                                   20


<210>  18138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18138
uuccuugcag aagaccaagu                                                   20


<210>  18139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18139
cgugugccca gcccagggcc                                                   20


<210>  18140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18140
cacgugugcc cagcccaggg                                                   20


<210>  18141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18141
gggcugcggg gauucugucc                                                   20


<210>  18142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18142
ggcaccacgu guggaggucg                                                   20


<210>  18143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18143
acacguggug ccugaggaaa                                                   20


<210>  18144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18144
guucauuuua gaaaacccag                                                   20


<210>  18145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18145
uagggaugua gggccucagu                                                   20


<210>  18146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18146
agaaucaggu cuaacacuaa                                                   20


<210>  18147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18147
agugagugag auuuuccuuu                                                   20


<210>  18148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18148
agggggugug guuucugguc                                                   20


<210>  18149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18149
cucgaggggg ugugguuucu                                                   20


<210>  18150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18150
cucacucgag gggguguggu                                                   20


<210>  18151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18151
aaaggaaaau cucacucacu                                                   20


<210>  18152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18152
ugccuguaau cccagcacuu                                                   20


<210>  18153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18153
agugauccgc ccaccuuggc                                                   20


<210>  18154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18154
aaauccugac cucaagugau                                                   20


<210>  18155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18155
acuaaaaaua uaaaaauuag                                                   20


<210>  18156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18156
ggagacugag acaggagaau                                                   20


<210>  18157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18157
ugaguagcug ggauuacagg                                                   20


<210>  18158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18158
gucuccugag uagcugggau                                                   20


<210>  18159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18159
ugucucaguc uccugaguag                                                   20


<210>  18160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18160
uggguucaag cgauucuccu                                                   20


<210>  18161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18161
gcuuacugca accuucgccu                                                   20


<210>  18162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18162
agccugggca acagagcaag                                                   20


<210>  18163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18163
guugcccagg cuagagugca                                                   20


<210>  18164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18164
gucucaaaaa aaaaaaaggu                                                   20


<210>  18165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18165
aaaaaaaaaa agguaggugu                                                   20


<210>  18166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18166
uguuaucuga aacaaggguu                                                   20


<210>  18167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18167
ucauguuauc ugaaacaagg                                                   20


<210>  18168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18168
agcuaagcuc cucauguuau                                                   20


<210>  18169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18169
ucaagcuaag cuccucaugu                                                   20


<210>  18170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18170
ccucaagcua agcuccucau                                                   20


<210>  18171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18171
cucuccucaa gcuaagcucc                                                   20


<210>  18172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18172
aucaacccuc acucuccuca                                                   20


<210>  18173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18173
caccagcccg cugaaauaag                                                   20


<210>  18174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18174
ggcaggaaag aaaggccgac                                                   20


<210>  18175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18175
cacccugcca ggucggccuu                                                   20


<210>  18176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18176
cugaccuaca ccugcuggcu                                                   20


<210>  18177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18177
auucucccug accuacaccu                                                   20


<210>  18178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18178
ucccugggac cuggcuccau                                                   20


<210>  18179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18179
ggcagccaca agccucuucc                                                   20


<210>  18180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18180
agcauacaua cacacacgug                                                   20


<210>  18181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18181
ccagcauaca uacacacacg                                                   20


<210>  18182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18182
cuagacucuc cagcauacau                                                   20


<210>  18183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18183
aaggacgcag uauuguuuga                                                   20


<210>  18184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18184
ggaucaaaca auacugcguc                                                   20


<210>  18185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18185
caggaucaaa caauacugcg                                                   20


<210>  18186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18186
ucuucggaau aagcccgcca                                                   20


<210>  18187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18187
cuguucugca acugcuucca                                                   20


<210>  18188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18188
ucccaggaaa gccuacaacu                                                   20


<210>  18189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18189
cuucccagga aagccuacaa                                                   20


<210>  18190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18190
agcaccccug cugcucucuu                                                   20


<210>  18191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18191
cggccccacu cuuggugcac                                                   20


<210>  18192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18192
gccccacucu uggugcacag                                                   20


<210>  18193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18193
uggugcacag cgagucacug                                                   20


<210>  18194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18194
cugugcacca agaguggggc                                                   20


<210>  18195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18195
uaaccagaug cuaaugaacc                                                   20


<210>  18196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18196
uuuggagggg cucguggaga                                                   20


<210>  18197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18197
aaaggagcag uuacugucuc                                                   20


<210>  18198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18198
uggagaccau gcaggagggc                                                   20


<210>  18199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18199
acgagccccu ccaaaggagc                                                   20


<210>  18200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18200
ugcauggucu ccacgagccc                                                   20


<210>  18201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18201
agaccgugcc cuccugcaug                                                   20


<210>  18202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18202
ggacggcaug accucaagac                                                   20


<210>  18203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18203
ggugugcucu ggacggcaug                                                   20


<210>  18204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18204
agcaagcucu ucacuggcau                                                   20


<210>  18205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18205
ucacuggcau ugaggaguuc                                                   20


<210>  18206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18206
augccaguga agagcuugcu                                                   20


<210>  18207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18207
ucaaugccag ugaagagcuu                                                   20


<210>  18208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18208
gggaacuccu caaugccagu                                                   20


<210>  18209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18209
cccugggugg guaccagaga                                                   20


<210>  18210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18210
cugggugggu accagagagg                                                   20


<210>  18211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18211
gguacccacc cagggagaga                                                   20


<210>  18212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18212
cugguaccca cccagggaga                                                   20


<210>  18213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18213
ucucugguac ccacccaggg                                                   20


<210>  18214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18214
ccuaugcucc ucucugguac                                                   20


<210>  18215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18215
uuaaaucggu uaugcucccc                                                   20


<210>  18216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18216
cuuuaaaucg guuaugcucc                                                   20


<210>  18217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18217
ccacaggaaa gcccucucuu                                                   20


<210>  18218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18218
uaccucacca caggaaagcc                                                   20


<210>  18219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18219
augauaauga ccagcuaauc                                                   20


<210>  18220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18220
gccuuugugc agaugggcug                                                   20


<210>  18221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18221
cugaaggcau guaagcugag                                                   20


<210>  18222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18222
gcuuacaugc cuucagugag                                                   20


<210>  18223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18223
cggucuggcc agcucagcuu                                                   20


<210>  18224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18224
ggauucuucu gugcauggca                                                   20


<210>  18225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18225
gacaagugcc augcacagaa                                                   20


<210>  18226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18226
cgcacagaga acuggacuuc                                                   20


<210>  18227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18227
gugcgugagg ugcucagaca                                                   20


<210>  18228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18228
gaaguccagu ucucugugcg                                                   20


<210>  18229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18229
gauauguuua uuggcaagca                                                   20


<210>  18230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18230
uugaacgccu gccuuuauuc                                                   20


<210>  18231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18231
cccacaaaca gcaggugcug                                                   20


<210>  18232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18232
aacuccugcc ugcuucuccc                                                   20


<210>  18233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18233
ugccugcuuc ucccagcacu                                                   20


<210>  18234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18234
cagcacuccc ugaguggggu                                                   20


<210>  18235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18235
cugagugggg ugugccagca                                                   20


<210>  18236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18236
gggagugcug ggagaagcag                                                   20


<210>  18237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18237
ggaugaggac aggaaguggg                                                   20


<210>  18238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18238
uccugaggcu gcuggcacac                                                   20


<210>  18239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18239
cacuuccugu ccucauccug                                                   20


<210>  18240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18240
gcccucccac uuccuguccu                                                   20


<210>  18241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18241
caaaucugcu cugcccuccc                                                   20


<210>  18242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18242
aacugcuucc ugggacuucc                                                   20


<210>  18243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18243
cccagaaaac agcuccaacu                                                   20


<210>  18244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18244
gggacagugu ugggguagug                                                   20


<210>  18245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18245
cuaccccaac acugucccag                                                   20


<210>  18246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18246
ucacuacccc aacacugucc                                                   20


<210>  18247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18247
cuccucacua ccccaacacu                                                   20


<210>  18248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18248
acugggcucc cuccucacua                                                   20


<210>  18249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18249
ccacugggcu cccuccucac                                                   20


<210>  18250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18250
caguaugucu guccugacuc                                                   20


<210>  18251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18251
acucggauga ugucacuucc                                                   20


<210>  18252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18252
gaugauguca cuuccuuuuc                                                   20


<210>  18253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18253
gguguggaag cuuggauggu                                                   20


<210>  18254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18254
cgguuugggu gaccauccaa                                                   20


<210>  18255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18255
gggaaugcug ugccaaaauc                                                   20


<210>  18256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18256
acggggaucu cagggaaugc                                                   20


<210>  18257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18257
aggaaaagga agucuuuaag                                                   20


<210>  18258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18258
uuaaagacuu ccuuuuccug                                                   20


<210>  18259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18259
uggggccucu ccuucagguc                                                   20


<210>  18260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18260
ccuucagguc accauugucg                                                   20


<210>  18261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18261
uucaggucac cauugucgga                                                   20


<210>  18262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18262
cgguagaugu ccgacaaugg                                                   20


<210>  18263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18263
ggauuuccuc ccgguagaug                                                   20


<210>  18264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18264
uuugacucca gaaaagauuu                                                   20


<210>  18265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18265
agaaaagauu uaagcaugau                                                   20


<210>  18266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18266
uuuuauacug agaaaauaga                                                   20


<210>  18267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18267
guauaaaagg aguuuugcca                                                   20


<210>  18268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18268
cguuguccac uacacaugaa                                                   20


<210>  18269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18269
gaauguuuuc uuguguucac                                                   20


<210>  18270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18270
gugguccauu uucucauaug                                                   20


<210>  18271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18271
uaugggaaca agcagacggg                                                   20


<210>  18272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18272
cgucugcuug uucccauaug                                                   20


<210>  18273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18273
aucugcuccc gucugcuugu                                                   20


<210>  18274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18274
ccuuccccag agccuagagg                                                   20


<210>  18275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18275
ggggaaggcg agugccaaga                                                   20


<210>  18276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18276
aggcucuggg gaaggcgagu                                                   20


<210>  18277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18277
ccaugcugcc ucuaggcucu                                                   20


<210>  18278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18278
gacaguccug gucugcuucc                                                   20


<210>  18279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18279
uaccugagca gcgcagggca                                                   20


<210>  18280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18280
gguaggaggg cuggaagcag                                                   20


<210>  18281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18281
agagacccuc aguuuuguca                                                   20


<210>  18282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18282
agagguuaga cggacuugcc                                                   20


<210>  18283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18283
guuuugucau auguaaaaug                                                   20


<210>  18284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18284
ugccaucaaa uaggggcaaa                                                   20


<210>  18285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18285
gugacugugc ccugcugugg                                                   20


<210>  18286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18286
acuguccagu ccucucccca                                                   20


<210>  18287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18287
ccccaguccc ucgggcuucu                                                   20


<210>  18288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18288
ccagucccuc gggcuucugc                                                   20


<210>  18289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18289
ggcuucugca gauuugaggc                                                   20


<210>  18290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18290
aaucugcaga agcccgaggg                                                   20


<210>  18291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18291
ugccacaacc uucugggauc                                                   20


<210>  18292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18292
acuuuccccu uuauaauuca                                                   20


<210>  18293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18293
uuggacauug aauuauaaag                                                   20


<210>  18294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18294
cuuuggacau ugaauuauaa                                                   20


<210>  18295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18295
gggcucucuu uggacauuga                                                   20


<210>  18296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18296
cgccagcugc cucacggagc                                                   20


<210>  18297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18297
cggagcuccu ccucuuccug                                                   20


<210>  18298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18298
gugaggcagc uggcgugagg                                                   20


<210>  18299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18299
uccucuuccu ggcugugagg                                                   20


<210>  18300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18300
ucuuccuggc ugugaggauc                                                   20


<210>  18301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18301
uccuggcugu gaggaucggu                                                   20


<210>  18302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18302
cagccaggaa gaggaggagc                                                   20


<210>  18303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18303
ugcucucucc cccuugccua                                                   20


<210>  18304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18304
cucccccuug ccuaacacga                                                   20


<210>  18305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18305
cccccuugcc uaacacgagc                                                   20


<210>  18306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18306
cccuugccua acacgagcac                                                   20


<210>  18307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18307
uguuaggcaa gggggagaga                                                   20


<210>  18308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18308
ugaacugccc aucggacgug                                                   20


<210>  18309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18309
uuuucuuugu ucauuuuuuu                                                   20


<210>  18310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18310
ccuucucucu gucucuuguu                                                   20


<210>  18311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18311
uucucucugu cucuuguucu                                                   20


<210>  18312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18312
cugucucuug uucuuucuuu                                                   20


<210>  18313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18313
gucucuuguu cuuucuuuac                                                   20


<210>  18314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18314
uguucuuucu uuaccccguu                                                   20


<210>  18315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18315
aguucuccug uccuaagcac                                                   20


<210>  18316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18316
uguccuaagc accccauccc                                                   20


<210>  18317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18317
cuggccuuac cacaaguggc                                                   20


<210>  18318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18318
ggccuuacca caaguggcgu                                                   20


<210>  18319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18319
gacaucauga uggggacaug                                                   20


<210>  18320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18320
aaugcagcuc aucaauaggg                                                   20


<210>  18321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18321
ucaauaggga uggagggucu                                                   20


<210>  18322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18322
aucccuauug augagcugca                                                   20


<210>  18323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18323
uuuuaaucua uucuucuaga                                                   20


<210>  18324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18324
gaccugucua gaagaauaga                                                   20


<210>  18325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18325
auaaagcugc uaaaaauuua                                                   20


<210>  18326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18326
aagcggacag cuugguggcc                                                   20


<210>  18327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18327
guggauaaaa cuaauggcca                                                   20


<210>  18328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18328
gggcuggacu ccagggaaga                                                   20


<210>  18329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18329
agggaagauu uuagcccauu                                                   20


<210>  18330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18330
cuaaaugggc uaaaaucuuc                                                   20


<210>  18331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18331
ugcagggcca gggccacuuc                                                   20


<210>  18332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18332
acuggggguu gaccaggcug                                                   20


<210>  18333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18333
caugugucuc ggacagugca                                                   20


<210>  18334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18334
ugugucucgg acagugcagc                                                   20


<210>  18335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18335
gacagugcag ccgaugucua                                                   20


<210>  18336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18336
augaugaaau ggaggggaua                                                   20


<210>  18337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18337
auuucaucau ugaggaaacc                                                   20


<210>  18338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18338
cacaguucua ugaugcgggg                                                   20


<210>  18339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18339
cugcccuugg cguggagccu                                                   20


<210>  18340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18340
acgccaaggg cagugagucc                                                   20


<210>  18341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18341
aggggccgug cugugucggc                                                   20


<210>  18342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18342
ccguuacagg cuugagaagg                                                   20


<210>  18343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18343
guuacaggcu ugagaagggu                                                   20


<210>  18344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18344
agccuguaac ggagagcuga                                                   20


<210>  18345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18345
cucauguaac auuuauauuu                                                   20


<210>  18346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18346
cauguaacau uuauauuucu                                                   20


<210>  18347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18347
uguaacauuu auauuucuag                                                   20


<210>  18348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18348
guuugaagaa acuugggcca                                                   20


<210>  18349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18349
uugguguccu ggugacgcag                                                   20


<210>  18350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18350
ugauggagca ggaggagagc                                                   20


<210>  18351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18351
aucacgaggg gcugcgucac                                                   20


<210>  18352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18352
ugcuccauca cgaggggcug                                                   20


<210>  18353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18353
uccugcucca ucacgagggg                                                   20


<210>  18354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18354
ccuccugcuc caucacgagg                                                   20


<210>  18355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18355
uaccuuauuu uugaaagagu                                                   20


<210>  18356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18356
uucaaaaaua agguaagaga                                                   20


<210>  18357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18357
ggaauaucag ucaagacacc                                                   20


<210>  18358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18358
gcaggcuuug ucccugcucu                                                   20


<210>  18359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18359
gaauauugau aaacuaaaag                                                   20


<210>  18360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18360
ucugaauauu gauaaacuaa                                                   20


<210>  18361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18361
uggccuuuau aaagugccuu                                                   20


<210>  18362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18362
gcaagacauu agaaaaauga                                                   20


<210>  18363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18363
gguacagcgg agccagcaga                                                   20


<210>  18364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18364
gcuguaccag agcacaguua                                                   20


<210>  18365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18365
cagaaaugac aguuuggagg                                                   20


<210>  18366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18366
aaacugucau uucugugagu                                                   20


<210>  18367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18367
uacauuuuac aggccuugcu                                                   20


<210>  18368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18368
aaacaugaau uacuuuuuaa                                                   20


<210>  18369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18369
uuugggcaca aaacuccaaa                                                   20


<210>  18370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18370
gcacacacgg gcccugaaac                                                   20


<210>  18371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18371
cggggcacaa ggcagggccu                                                   20


<210>  18372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18372
gccugacaga aauccuuugg                                                   20


<210>  18373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18373
ucuuccuccc auugaggcag                                                   20


<210>  18374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18374
uccucccauu gaggcaggga                                                   20


<210>  18375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18375
cauugaggca gggaagacuc                                                   20


<210>  18376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18376
augggaggaa gaggagccuu                                                   20


<210>  18377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18377
ggguucugca ggcagaggug                                                   20


<210>  18378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18378
gccugcagaa cccagagucu                                                   20


<210>  18379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18379
uguugacaug ugggcucucc                                                   20


<210>  18380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18380
ccuuccagga agacacagag                                                   20


<210>  18381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18381
uuccaggaag acacagagag                                                   20


<210>  18382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18382
gugucuuccu ggaaggagag                                                   20


<210>  18383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18383
cugugucuuc cuggaaggag                                                   20


<210>  18384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18384
cuggugcuca gugcaaugac                                                   20


<210>  18385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18385
gugcaaugac ugugccugug                                                   20


<210>  18386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18386
aagcagcuua cagcuggguu                                                   20


<210>  18387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18387
gaaagcucuc gacaccaggu                                                   20


<210>  18388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18388
cgacaccagg uuugcuugag                                                   20


<210>  18389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18389
acaccagguu ugcuugaguu                                                   20


<210>  18390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18390
agcaaaccug gugucgagag                                                   20


<210>  18391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18391
gggacauagc aggugcuggg                                                   20


<210>  18392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18392
ugcacaggcc acacggacgg                                                   20


<210>  18393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18393
uggucaguga gaagcuggaa                                                   20


<210>  18394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18394
cugaccagga ggccaccuuu                                                   20


<210>  18395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18395
auaaccccac gucaguuccu                                                   20


<210>  18396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18396
gcuaacgucu uccccuaaau                                                   20


<210>  18397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18397
uuccugcucu gcuaacgucu                                                   20


<210>  18398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18398
cggacaggug cucacuuagg                                                   20


<210>  18399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18399
cuuaggaagu gaguuucauu                                                   20


<210>  18400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18400
cuuccuaagu gagcaccugu                                                   20


<210>  18401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18401
gcuuugccua aaggaaccug                                                   20


<210>  18402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18402
uuaccuuuuu ucuaaaaugu                                                   20


<210>  18403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18403
caaaccuaca uuuuagaaaa                                                   20


<210>  18404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18404
gcuuccuccc aaaccuacau                                                   20


<210>  18405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18405
gauaaugcuc agcuuccucc                                                   20


<210>  18406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18406
acaaucccuc ugauaaugcu                                                   20


<210>  18407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18407
ugcuccacaa ucccucugau                                                   20


<210>  18408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18408
uugaaaccau ugcuugaauc                                                   20


<210>  18409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18409
cuuugaaacc auugcuugaa                                                   20


<210>  18410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18410
cucuuugaaa ccauugcuug                                                   20


<210>  18411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18411
gucuccggcu acuacaggua                                                   20


<210>  18412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18412
ggcuacuaca gguaccugag                                                   20


<210>  18413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18413
gguaccugua guagccggag                                                   20


<210>  18414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18414
cccgcacccu uucccucagg                                                   20


<210>  18415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18415
uucuagccca aguacaaccg                                                   20


<210>  18416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18416
cauucuagcc caaguacaac                                                   20


<210>  18417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18417
ccacaccagu gaugcgggaa                                                   20


<210>  18418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18418
ggucuucccg caucacuggu                                                   20


<210>  18419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18419
gaccacacuc aggucuuccc                                                   20


<210>  18420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18420
aacucagacc acacucaggu                                                   20


<210>  18421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18421
ugcuuaugaa aggggcagcg                                                   20


<210>  18422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18422
cugggccuga cuaagacucc                                                   20


<210>  18423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18423
uucauuucca gauuuuacuu                                                   20


<210>  18424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18424
ccugccaguc aagaaaugag                                                   20


<210>  18425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18425
ugccagucaa gaaaugagaa                                                   20


<210>  18426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18426
uuucuugacu ggcaggagag                                                   20


<210>  18427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18427
cgggcuguaa gaccagcagg                                                   20


<210>  18428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18428
accaaguuca ucuacacaag                                                   20


<210>  18429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18429
agcuuuuccu aagaaaccau                                                   20


<210>  18430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18430
ggcccagcug ugcccugccc                                                   20


<210>  18431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18431
cugcaccucu ccccucccug                                                   20


<210>  18432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18432
ccccucccug ggcccugccu                                                   20


<210>  18433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18433
ccucccuggg cccugccugu                                                   20


<210>  18434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18434
cugggcccug ccugucacug                                                   20


<210>  18435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18435
cccaccaagc cuuccgguug                                                   20


<210>  18436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18436
caccaagccu uccgguugug                                                   20


<210>  18437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18437
gaugccugug auagggcagg                                                   20


<210>  18438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18438
ucuuuuaaac caggugacaa                                                   20


<210>  18439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18439
cuucuuuuaa accaggugac                                                   20


<210>  18440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18440
aaaguauuuu agcguagagc                                                   20


<210>  18441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18441
acgcuaaaau acuuuugagu                                                   20


<210>  18442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18442
gugauuccgu agcuauuuag                                                   20


<210>  18443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18443
uaaauagcua cggaaucaca                                                   20


<210>  18444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18444
uagacacugc guauaacaca                                                   20


<210>  18445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18445
aauguuuauu agggcguuga                                                   20


<210>  18446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18446
guuuacuuca acgcccuaau                                                   20


<210>  18447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18447
aagugcucag uuuacuucaa                                                   20


<210>  18448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18448
uugaaggcug gauccauggc                                                   20


<210>  18449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18449
uaagucagga ggacccagga                                                   20


<210>  18450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18450
ugacuuauga gcuccuugaa                                                   20


<210>  18451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18451
uggguccucc ugacuuauga                                                   20


<210>  18452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18452
uuucugccuu cuaugacagg                                                   20


<210>  18453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18453
gugccccucu uuucugccuu                                                   20


<210>  18454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18454
cacccaccuc ugugccccuc                                                   20


<210>  18455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18455
uggagcucca aggggagcaa                                                   20


<210>  18456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18456
aggagcugcc uguguaugcc                                                   20


<210>  18457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18457
aaggggagca agugcuucca                                                   20


<210>  18458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18458
ccuuggagcu ccaggagcug                                                   20


<210>  18459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18459
acgcccccuu cccuggaagc                                                   20


<210>  18460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18460
aaaggggccu ccacgccccc                                                   20


<210>  18461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18461
uccaaagggg ccuccacgcc                                                   20


<210>  18462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18462
gccagacccc agaucaacuu                                                   20


<210>  18463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18463
cgcuaaaugu ccccagcuaa                                                   20


<210>  18464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18464
ugucuuucug cugggcaucc                                                   20


<210>  18465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18465
ucaugucuuu cugcugggca                                                   20


<210>  18466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18466
cgcuccugcc ggcuguaucu                                                   20


<210>  18467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18467
ugccggcugu aucuggucag                                                   20


<210>  18468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18468
gugcccaggc ugaccagaua                                                   20


<210>  18469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18469
gggggaccca gauaagcauu                                                   20


<210>  18470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18470
cugggggacc cagauaagca                                                   20


<210>  18471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18471
ccugcaacug cugacuccua                                                   20


<210>  18472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18472
uaagcuuuug cagcucagcc                                                   20


<210>  18473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18473
gcccacaacc aguuccuauu                                                   20


<210>  18474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18474
gugaauagga acugguugug                                                   20


<210>  18475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18475
caccucugug aauaggaacu                                                   20


<210>  18476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18476
gcucccaccu cugugaauag                                                   20


<210>  18477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18477
augacaaaua agacugcagc                                                   20


<210>  18478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18478
gucacuuuuu cucuaugaca                                                   20


<210>  18479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18479
gcacaaccug ggcccuccug                                                   20


<210>  18480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18480
ugccaguggc ggcgagggca                                                   20


<210>  18481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18481
ccgccacugg caggagggcc                                                   20


<210>  18482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18482
cggcugggug ccugucuggg                                                   20


<210>  18483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18483
ugcccagaca ggcacccagc                                                   20


<210>  18484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18484
gggugcuggu guucacaggu                                                   20


<210>  18485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18485
ucagccacga gaagcugcug                                                   20


<210>  18486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18486
uggcugauga gggcaccugu                                                   20


<210>  18487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18487
ggguugaucu guagcagcag                                                   20


<210>  18488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18488
cgcucggggu ugaucuguag                                                   20


<210>  18489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18489
ccagcucccg cucgggguug                                                   20


<210>  18490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18490
ugcuccccag cucccgcucg                                                   20


<210>  18491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18491
gccaggucag ucucgcgccc                                                   20


<210>  18492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18492
cgcccccgcc gccuggccuc                                                   20


<210>  18493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18493
guccguuucu guccucagac                                                   20


<210>  18494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18494
gacuuuggcg cuugacacac                                                   20


<210>  18495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18495
uggguguguc aagcgccaaa                                                   20


<210>  18496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18496
gugcacuuuu uaaaugaaag                                                   20


<210>  18497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18497
gcuugcggga ccuaggaaua                                                   20


<210>  18498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18498
uaacuacuuu cuggaauaca                                                   20


<210>  18499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18499
cauguagcga uagagaugug                                                   20


<210>  18500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18500
aucgcuacau gugaggucuc                                                   20


<210>  18501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18501
uacacacauc ucuaucgcua                                                   20


<210>  18502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18502
cugucucuua cacacaucuc                                                   20


<210>  18503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18503
cacugucucu uacacacauc                                                   20


<210>  18504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18504
cgguccuugc uuaaguccaa                                                   20


<210>  18505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18505
ccccccuuuu ugugucucac                                                   20


<210>  18506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18506
guccucaccc cccuuuuugu                                                   20


<210>  18507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18507
acucuguccu caccccccuu                                                   20


<210>  18508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18508
ggaggaagua gacgccauga                                                   20


<210>  18509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18509
ugagcauuuc agcugacucc                                                   20


<210>  18510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18510
cggccacgcc ugcggccccc                                                   20


<210>  18511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18511
uggggggcuc ccugaguguc                                                   20


<210>  18512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18512
cugagugucc cugucccugu                                                   20


<210>  18513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18513
gggagccccc caagagcugg                                                   20


<210>  18514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18514
cacccagaac uggccacagg                                                   20


<210>  18515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18515
gccacuuccu agcaggucac                                                   20


<210>  18516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18516
ucagauaagu gaagggauuc                                                   20


<210>  18517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18517
gauaagugaa gggauucaag                                                   20


<210>  18518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18518
uaaaauguua uagauuacag                                                   20


<210>  18519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18519
gccuccuaaa auguuauaga                                                   20


<210>  18520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18520
ugccucagcc uccuaaaaug                                                   20


<210>  18521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18521
gguaagccuc cugccucagc                                                   20


<210>  18522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18522
ggagguugag gcugcaguga                                                   20


<210>  18523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18523
ugagcucagg uaagccuccu                                                   20


<210>  18524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18524
accuccugag cucagguaag                                                   20


<210>  18525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18525
cugcagccuc aaccuccuga                                                   20


<210>  18526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18526
agccugggca acagaccagu                                                   20


<210>  18527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18527
gucccuuaaa aaaaaaugua                                                   20


<210>  18528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18528
acgccaugug ccaucauaug                                                   20


<210>  18529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18529
accccggugc ugugucuuuc                                                   20


<210>  18530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18530
ccggguuccu gauuuaguga                                                   20


<210>  18531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18531
uuguagcuuu uguuucugug                                                   20


<210>  18532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18532
uaaguguuuc uaaacaccau                                                   20


<210>  18533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18533
gagaguuucc ucuucugagu                                                   20


<210>  18534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18534
gagcucauaa guguuucuaa                                                   20


<210>  18535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18535
cagagcucau aaguguuucu                                                   20


<210>  18536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18536
ucugaguucc uggccugcag                                                   20


<210>  18537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18537
gaagaggaaa cucucagagc                                                   20


<210>  18538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18538
cugccuguac uguccuguuu                                                   20


<210>  18539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18539
gccuguacug uccuguuuug                                                   20


<210>  18540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18540
cugcuuccug ucacugaaac                                                   20


<210>  18541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18541
ucuguccuuu caccuuugac                                                   20


<210>  18542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18542
gccugcccuu cagaaacacu                                                   20


<210>  18543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18543
cagccugccc uucagaaaca                                                   20


<210>  18544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18544
cucucagccu gcccuucaga                                                   20


<210>  18545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18545
cacucucagc cugcccuuca                                                   20


<210>  18546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18546
cugggugccu cuggccuugu                                                   20


<210>  18547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18547
ggccuugucc ugggcccagg                                                   20


<210>  18548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18548
ggcacagacc agugucccug                                                   20


<210>  18549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18549
guccaguggc aucuaggggc                                                   20


<210>  18550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18550
uucccaaaag caaguagcgg                                                   20


<210>  18551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18551
cccagacccc uaacccccac                                                   20


<210>  18552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18552
ccucgcccag accccuaacc                                                   20


<210>  18553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18553
uccuuggccu gagagcuguu                                                   20


<210>  18554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18554
uuggccugag agcuguucau                                                   20


<210>  18555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18555
ggccaaggag gagccccugc                                                   20


<210>  18556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18556
caggccaagg aggagccccu                                                   20


<210>  18557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18557
ucgcccacuc ccugcagggu                                                   20


<210>  18558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18558
cccacucccu gcagggugcu                                                   20


<210>  18559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18559
cugcagggug cuggguccca                                                   20


<210>  18560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18560
cguucuuggc accaagggcc                                                   20


<210>  18561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18561
aucaucacug gcacuagccc                                                   20


<210>  18562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18562
aggcuucccg agaaccaggc                                                   20


<210>  18563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18563
agcacuuggc acagugcugu                                                   20


<210>  18564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18564
ggaagccucg agcacuuggc                                                   20


<210>  18565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18565
uuucugccug guucucggga                                                   20


<210>  18566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18566
acuguccucc uuucugccug                                                   20


<210>  18567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18567
agaucacgca gccaccacgc                                                   20


<210>  18568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18568
cgccuuugug acccgcgcuc                                                   20


<210>  18569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18569
cucgcgccuu ugugacccgc                                                   20


<210>  18570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18570
ggccuugggu uuaccgcaau                                                   20


<210>  18571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18571
cgcacuggca gucauugcgg                                                   20


<210>  18572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18572
cguauugguu ccguguuuug                                                   20


<210>  18573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18573
auucagaugu cacuuaggag                                                   20


<210>  18574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18574
uaagugacau cugaauggag                                                   20


<210>  18575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18575
acgaagggau gcuuucacuc                                                   20


<210>  18576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18576
uucuguguca cccuccucag                                                   20


<210>  18577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18577
ucagcugcuc cugggguuga                                                   20


<210>  18578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18578
gcugcuccug ggguugacug                                                   20


<210>  18579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18579
ugggguugac uggccccuga                                                   20


<210>  18580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18580
agcacaugcu aaaggcauga                                                   20


<210>  18581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18581
cugugggcuc ccuugcccgu                                                   20


<210>  18582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18582
gugggcuccc uugcccguaa                                                   20


<210>  18583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18583
cuugcccgua accuggggug                                                   20


<210>  18584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18584
gcacaugccu accgucuaac                                                   20


<210>  18585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18585
uggugggugg guguggccac                                                   20


<210>  18586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18586
gugcugcggc cacagugcca                                                   20


<210>  18587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18587
guguggcugg ggaacagcau                                                   20


<210>  18588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18588
ggggugugau gcuguucccc                                                   20


<210>  18589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18589
cucaggggug ugaugcuguu                                                   20


<210>  18590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18590
ucccucaggg gugugaugcu                                                   20


<210>  18591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18591
ucccauuccu ccucccucag                                                   20


<210>  18592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18592
uccucguccc auuccuccuc                                                   20


<210>  18593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18593
ucuuccucgu cccauuccuc                                                   20


<210>  18594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18594
uccucuuccu cgucccauuc                                                   20


<210>  18595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18595
uccuccucuu ccucguccca                                                   20


<210>  18596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18596
agucaacucc agguuuucca                                                   20


<210>  18597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18597
agguuuucca auggccuuuu                                                   20


<210>  18598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18598
aacaaaucaa augacugaua                                                   20


<210>  18599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18599
uuucaagaag caccucaaac                                                   20


<210>  18600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18600
caucucaugu acuuggaaaa                                                   20


<210>  18601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18601
ucucauguac uuggaaaaua                                                   20


<210>  18602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18602
uguacuugga aaauacccau                                                   20


<210>  18603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18603
cauauuccac aggaaacacc                                                   20


<210>  18604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18604
agcccggugu uuccugugga                                                   20


<210>  18605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18605
uguucgcagu uuuugcuuga                                                   20


<210>  18606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18606
agcaaaaacu gcgaacagga                                                   20


<210>  18607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18607
gccaggagga ccccggccau                                                   20


<210>  18608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18608
uggcugagcu ggacggcagg                                                   20


<210>  18609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18609
cugaucagga uggccggggu                                                   20


<210>  18610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18610
cuuacggauc ugaccaccuc                                                   20


<210>  18611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18611
caccugcacg ugccacacgc                                                   20


<210>  18612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18612
ugcaugcaac acacacacag                                                   20


<210>  18613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18613
acaugcaugc accacacaca                                                   20


<210>  18614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18614
uggguguaag aacacgacuu                                                   20


<210>  18615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18615
ccuugcccuc cugguuuucc                                                   20


<210>  18616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18616
ugguuuucca caucuccagc                                                   20


<210>  18617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18617
agcuucuagu ggucucagac                                                   20


<210>  18618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18618
gacuuguuca ccgagcgcaa                                                   20


<210>  18619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18619
gugaacaagu cugagaccac                                                   20


<210>  18620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18620
aacugguugc gcucggugaa                                                   20


<210>  18621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18621
ucuucugaag ggugcacccu                                                   20


<210>  18622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18622
cucaguaccu ggugccugcc                                                   20


<210>  18623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18623
guaccuggug ccugccaccu                                                   20


<210>  18624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18624
gugccaccug ucacuuacca                                                   20


<210>  18625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18625
ggccaacacc aggucccaag                                                   20


<210>  18626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18626
uuccaagagu ugacccgaac                                                   20


<210>  18627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18627
uggaaggagg cagccgcacc                                                   20


<210>  18628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18628
acggcccacg ugagcugcag                                                   20


<210>  18629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18629
cgugggccgu ggaguccggu                                                   20


<210>  18630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18630
gauggagggg guucagcgac                                                   20


<210>  18631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18631
aucugagaag cacugcagcu                                                   20


<210>  18632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18632
gcgccaccac acaccguggu                                                   20


<210>  18633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18633
gcccugaggc cugacugccu                                                   20


<210>  18634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18634
gggcagagca uggggaagcc                                                   20


<210>  18635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18635
cuccccuucu caguuauguu                                                   20


<210>  18636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18636
ccuucucagu uauguuccag                                                   20


<210>  18637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18637
guuauguucc aggccccccg                                                   20


<210>  18638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18638
gggggccugg aacauaacug                                                   20


<210>  18639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18639
ccugggggcc guuuugucac                                                   20


<210>  18640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18640
ugggggccgu uuugucacag                                                   20


<210>  18641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18641
uuuuagcgug gugguugucu                                                   20


<210>  18642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18642
ccguucuggg ggcuggaagu                                                   20


<210>  18643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18643
ucacacacca aaucugcugg                                                   20


<210>  18644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18644
cugcuucaua gauggcaucu                                                   20


<210>  18645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18645
gcuucauaga uggcaucuuc                                                   20


<210>  18646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18646
cgguggaagg agugaacaag                                                   20


<210>  18647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18647
uuccaccgug aggacccagc                                                   20


<210>  18648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18648
cucaggccuu uuagaagggc                                                   20


<210>  18649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18649
ggccuuuuag aagggcccca                                                   20


<210>  18650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18650
cccaucauga ccucaucacc                                                   20


<210>  18651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18651
caucaugacc ucaucaccuc                                                   20


<210>  18652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18652
ucaccuccca aggccccacc                                                   20


<210>  18653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18653
caaggcccca ccuucuugua                                                   20


<210>  18654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18654
uacacugaca ccuaauuugc                                                   20


<210>  18655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18655
ugaaacuccu acacugacac                                                   20


<210>  18656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18656
ugaguuccuc cuuauucugc                                                   20


<210>  18657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18657
agaggaugaa cacuugaccg                                                   20


<210>  18658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18658
uuauucugcu ucugguuuau                                                   20


<210>  18659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18659
gacaguucug ccauccuuga                                                   20


<210>  18660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18660
gguuccuugu cauguggcau                                                   20


<210>  18661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18661
uuucuucaac aaacaccuga                                                   20


<210>  18662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18662
gguguuuguu gaagaaauga                                                   20


<210>  18663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18663
ccaagggccc cagacggcug                                                   20


<210>  18664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18664
ggacgggcuc cuguguguca                                                   20


<210>  18665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18665
ugugugucag gaacgacaau                                                   20


<210>  18666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18666
agccgcuaac auuugcggag                                                   20


<210>  18667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18667
gcaaauguua gcggcuggag                                                   20


<210>  18668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18668
uccucccgca cccccaccug                                                   20


<210>  18669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18669
cgcaccccca ccugacaagg                                                   20


<210>  18670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18670
gaccuuggcc gccuagggug                                                   20


<210>  18671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18671
gcugcauuuu gugugaccca                                                   20


<210>  18672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18672
accucugcug cauuuugugu                                                   20


<210>  18673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18673
ccucaaccuc ugcugcauuu                                                   20


<210>  18674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18674
aggucacgga caugugcuca                                                   20


<210>  18675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18675
cucucugcga gucuugacug                                                   20


<210>  18676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18676
cugcgagucu ugacugcucu                                                   20


<210>  18677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18677
gcgagucuug acugcucuug                                                   20


<210>  18678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18678
cagagaggga gucaggcucc                                                   20


<210>  18679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18679
ugccuagacu cuguccuccc                                                   20


<210>  18680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18680
guccuccccg agcccaaacg                                                   20


<210>  18681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18681
ccgagcccaa acgccaguca                                                   20


<210>  18682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18682
gggaggacag agucuaggca                                                   20


<210>  18683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18683
gcagccgucc agggagugga                                                   20


<210>  18684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18684
cuggacggcu gcugagucac                                                   20


<210>  18685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18685
auuguuucca cucccuggac                                                   20


<210>  18686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18686
cuucacggcg aacacccucu                                                   20


<210>  18687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18687
ucacggcgaa cacccucugg                                                   20


<210>  18688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18688
ggguguugcc cacacgaugu                                                   20


<210>  18689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18689
uggaaggggu ccuucuccuu                                                   20


<210>  18690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18690
uuugugggaa guuucagcug                                                   20


<210>  18691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18691
ggcccagauc ccccuaggca                                                   20


<210>  18692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18692
uuugauuacu gauggcacaa                                                   20


<210>  18693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18693
cucccagcuc uuugugcacu                                                   20


<210>  18694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18694
cagcucuuug ugcacucaug                                                   20


<210>  18695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18695
uugugcacuc augcuuucug                                                   20


<210>  18696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18696
ugcuuucugg aagauggcca                                                   20


<210>  18697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18697
gugaagguuu ucagcgcguc                                                   20


<210>  18698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18698
ggauacgugg guaccaagca                                                   20


<210>  18699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18699
aaacgacaug cucuggauac                                                   20


<210>  18700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18700
gguggcacgg auuucacaac                                                   20


<210>  18701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18701
cggguggcac ggauuucaca                                                   20


<210>  18702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18702
cuaaggacug cguacggccc                                                   20


<210>  18703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18703
cacgcacaac gccacacggc                                                   20


<210>  18704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18704
cccugugcua uccccucaca                                                   20


<210>  18705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18705
ucuuuugguc cuuguuccug                                                   20


<210>  18706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18706
uuugguccuu guuccuggga                                                   20


<210>  18707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18707
cagccauccc aggaacaagg                                                   20


<210>  18708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18708
gcaggggaaa uggccggacg                                                   20


<210>  18709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18709
ccgcagggga aauggccgga                                                   20


<210>  18710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18710
uaccacugcc gagaaccuca                                                   20


<210>  18711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18711
gcagugguag gagccucucc                                                   20


<210>  18712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18712
ucauuccaca aaaacaagag                                                   20


<210>  18713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18713
uguuuuugug gaaugaugag                                                   20


<210>  18714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18714
augggaauuc ugugucccca                                                   20


<210>  18715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18715
uucagcccaa gacuaugggg                                                   20


<210>  18716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18716
ucacuguuaa agagcagauu                                                   20


<210>  18717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18717
cuguuaaaga gcagauugaa                                                   20


<210>  18718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18718
uuaacaguga ggagaccccu                                                   20


<210>  18719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18719
auuucacuua guauccaaaa                                                   20


<210>  18720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18720
cagcuaagau guguuauggu                                                   20


<210>  18721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18721
gcuaagaugu guuaugguaa                                                   20


<210>  18722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18722
gcccuugcua auuuucuuug                                                   20


<210>  18723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18723
ggacaucgcc ccaugggccu                                                   20


<210>  18724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18724
agccuggugu ccucgggaca                                                   20


<210>  18725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18725
cccagcgggg ucgugcagga                                                   20


<210>  18726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18726
cagcgggguc gugcaggacg                                                   20


<210>  18727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18727
ccgcacagug agccgugaca                                                   20


<210>  18728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18728
cugugcgggg aguuaagugc                                                   20


<210>  18729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18729
agugugcuuu ccuggcgacg                                                   20


<210>  18730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18730
gugccagggu uuuuacuggg                                                   20


<210>  18731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18731
gccugccucg ugcccagacu                                                   20


<210>  18732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18732
ugcccagacu cuggacuccc                                                   20


<210>  18733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18733
ggacucccgg agggaaggca                                                   20


<210>  18734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18734
cggagggaag gcaaguucuc                                                   20


<210>  18735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18735
gggaguccag agucugggca                                                   20


<210>  18736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18736
gcaccaaccc uggugcccac                                                   20


<210>  18737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18737
gcugcuugug ugggcaccag                                                   20


<210>  18738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18738
cugugcucag cugcuugugu                                                   20


<210>  18739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18739
ucagugagga uggugggcac                                                   20


<210>  18740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18740
gugaggaugg ugggcaccgu                                                   20


<210>  18741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18741
cugaggaggg gcucccugug                                                   20


<210>  18742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18742
caggaugguc uccggccugc                                                   20


<210>  18743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18743
ggauggucuc cggccugcug                                                   20


<210>  18744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18744
ggccugcugu guagucucuu                                                   20


<210>  18745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18745
ucugcacaca agcgugaggg                                                   20


<210>  18746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18746
cgcuugugug cagaagagac                                                   20


<210>  18747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18747
gcugugggga ggagccacug                                                   20


<210>  18748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18748
ccacagccga ggcgggggcg                                                   20


<210>  18749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18749
uccccacagc cgaggcgggg                                                   20


<210>  18750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18750
cgucccagug gcuccucccc                                                   20


<210>  18751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18751
gguggcaugc agcagcuuuu                                                   20


<210>  18752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18752
gccacggccu uguccuaggc                                                   20


<210>  18753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18753
agcaggcggc ugacaggcuc                                                   20


<210>  18754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18754
ccagcaggcg gcugacaggc                                                   20


<210>  18755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18755
ggagcagcca ccugcccagc                                                   20


<210>  18756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18756
ugagcgugcu cuccagcagg                                                   20


<210>  18757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18757
aacccugcug ggcagguggc                                                   20


<210>  18758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18758
augugcugga gugcgaccug                                                   20


<210>  18759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18759
agcacauaga ggacgccgug                                                   20


<210>  18760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18760
ucccggucau cagcgacuau                                                   20


<210>  18761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18761
ucuccaaccu gaaagggauc                                                   20


<210>  18762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18762
ccaaccugaa agggaucgcc                                                   20


<210>  18763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18763
aaccugaaag ggaucgccca                                                   20


<210>  18764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18764
cugggcgauc ccuuucaggu                                                   20


<210>  18765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18765
cacucacugg gcgaucccuu                                                   20


<210>  18766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18766
gaaugagcug ugaaggaagc                                                   20


<210>  18767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18767
uucugagacc cccgccccag                                                   20


<210>  18768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18768
ccaagugccc aggcuccugg                                                   20


<210>  18769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18769
aagugcccag gcuccuggcc                                                   20


<210>  18770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18770
uggccagaug gcaggccagg                                                   20


<210>  18771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18771
gccauggcac ccaccugggu                                                   20


<210>  18772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18772
cugaccucag ccauggcacc                                                   20


<210>  18773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18773
ugcgucucac ugaccucagc                                                   20


<210>  18774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18774
aggacgcacc ugugcucuug                                                   20


<210>  18775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18775
ggcaccucca gcgagcugga                                                   20


<210>  18776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18776
agcgagcugg agcucucgcc                                                   20


<210>  18777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18777
cuggaggugc ccgaggaagc                                                   20


<210>  18778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18778
agcucgcugg aggugcccga                                                   20


<210>  18779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18779
cgccucugcu gcugucucau                                                   20


<210>  18780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18780
ccucugcugc ugucucaugu                                                   20


<210>  18781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18781
gcugcugucu cauguggcgc                                                   20


<210>  18782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18782
uguggcgcuu agcacacucu                                                   20


<210>  18783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18783
cccacgugcc cauuccugac                                                   20


<210>  18784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18784
cacgugccca uuccugacuc                                                   20


<210>  18785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18785
gcucucgagg ccaucggcuc                                                   20


<210>  18786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18786
cgaggccauc ggcucucauu                                                   20


<210>  18787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18787
aggccaucgg cucucauucu                                                   20


<210>  18788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18788
agagcagagu caggaauggg                                                   20


<210>  18789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18789
cauucucugc ucccagaacc                                                   20


<210>  18790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18790
uucucugcuc ccagaacccu                                                   20


<210>  18791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18791
gcucccagaa cccuguuauu                                                   20


<210>  18792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18792
cagaacccug uuauuaccca                                                   20


<210>  18793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18793
ucucugcacc uuccccgccc                                                   20


<210>  18794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18794
cugcaccuuc cccgcccugg                                                   20


<210>  18795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18795
gcaccuuccc cgcccuggcc                                                   20


<210>  18796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18796
cucuuguuuc cacugugauu                                                   20


<210>  18797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18797
uguuuccacu gugauuccga                                                   20


<210>  18798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18798
ccuuaucuua aagcugcugg                                                   20


<210>  18799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18799
gcgagcaagu caagcucuuc                                                   20


<210>  18800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18800
cugagggguu gcggcaccag                                                   20


<210>  18801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18801
ucacagcgau gucuuacaag                                                   20


<210>  18802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18802
gcgcuuguaa gacaucgcug                                                   20


<210>  18803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18803
gugacacccu ggucucaccg                                                   20


<210>  18804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18804
ccgccacucu uccaaagucg                                                   20


<210>  18805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18805
uccaaagucg cagaggcuuu                                                   20


<210>  18806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18806
gcgacuuugg aagaguggcg                                                   20


<210>  18807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18807
gcuaaagccu cugcgacuuu                                                   20


<210>  18808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18808
cugagucaua ggcuucugca                                                   20


<210>  18809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18809
gagucauagg cuucugcaca                                                   20


<210>  18810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18810
gagaggcugg gcccaucucu                                                   20


<210>  18811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18811
cgugugcaga agccuaugac                                                   20


<210>  18812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18812
aaagacagcu cccgugugca                                                   20


<210>  18813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18813
cucuaaagac agcucccgug                                                   20


<210>  18814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18814
cccauguggg uggcugauga                                                   20


<210>  18815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18815
acucccccau guggguggcu                                                   20


<210>  18816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18816
uaauucuugc ccucaacucc                                                   20


<210>  18817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18817
cagaccccuu cccaucuuug                                                   20


<210>  18818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18818
acuuugaccu agcccccguu                                                   20


<210>  18819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18819
aggucuucca cucaacuuug                                                   20


<210>  18820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18820
cuccaggucu uccacucaac                                                   20


<210>  18821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18821
guaggcacag uucagacagg                                                   20


<210>  18822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18822
ugucugaacu gugccuacag                                                   20


<210>  18823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18823
cuccugucug aacugugccu                                                   20


<210>  18824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18824
caccucccuc cugucugaac                                                   20


<210>  18825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18825
agcauguccc aaauccugcc                                                   20


<210>  18826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18826
ucaggggcca uugcccucau                                                   20


<210>  18827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18827
uccaggccag agugucacaa                                                   20


<210>  18828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18828
ggccuggaug agggcaaugg                                                   20


<210>  18829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18829
ccacgggcuu gugacacucu                                                   20


<210>  18830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18830
ccugucaucc uugcugggca                                                   20


<210>  18831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18831
gcaucccugg agccuggcau                                                   20


<210>  18832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18832
agggaugcag agacaguugc                                                   20


<210>  18833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18833
ugcugugggc auggaggacu                                                   20


<210>  18834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18834
augcccacag caagagccau                                                   20


<210>  18835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18835
gggaaggaga guugaggugg                                                   20


<210>  18836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18836
uucccugagu ccuccaugcc                                                   20


<210>  18837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18837
ccuucccuga guccuccaug                                                   20


<210>  18838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18838
acucuccuuc ccugaguccu                                                   20


<210>  18839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18839
uggaccaccu caacucuccu                                                   20


<210>  18840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18840
gcaucccaaa cgcaacuccu                                                   20


<210>  18841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18841
cugcauccca aacgcaacuc                                                   20


<210>  18842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18842
gcaccauggg cagaggggcc                                                   20


<210>  18843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18843
gcccauggug cugaggucag                                                   20


<210>  18844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18844
gagguggagg ugggaccacg                                                   20


<210>  18845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18845
gaggcacgug acacggcccc                                                   20


<210>  18846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18846
accucggagg cacgugacac                                                   20


<210>  18847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18847
ucuguucaca guggccacuc                                                   20


<210>  18848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18848
guucacagug gccacucauu                                                   20


<210>  18849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18849
uucagucccu ggcuaccagg                                                   20


<210>  18850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18850
cugugccaug gggaaggccg                                                   20


<210>  18851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18851
ggaaguagag gggacuggcc                                                   20


<210>  18852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18852
acuuccugag ugcccugugc                                                   20


<210>  18853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18853
uugagggaca gagagaggaa                                                   20


<210>  18854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18854
acgaggcccu agauucccac                                                   20


<210>  18855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18855
gucccucaac gaggcccuag                                                   20


<210>  18856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18856
cugucccuca acgaggcccu                                                   20


<210>  18857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18857
cucugucccu caacgaggcc                                                   20


<210>  18858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18858
augcuggcca ccacacacuu                                                   20


<210>  18859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18859
ccuguggcca ccuccaugcu                                                   20


<210>  18860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18860
gccuccccug uggccaccuc                                                   20


<210>  18861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18861
gccuaacuca gccuccccug                                                   20


<210>  18862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18862
cggccuaacu cagccucccc                                                   20


<210>  18863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18863
ccaacgcccu gcccucucgg                                                   20


<210>  18864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18864
gccacucagg gaguggucaa                                                   20


<210>  18865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18865
gggagugguc aagcagaggc                                                   20


<210>  18866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18866
cugaguggcu gagcccgucu                                                   20


<210>  18867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18867
gcuugaccac ucccugagug                                                   20


<210>  18868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18868
cccaggcccc ugcaaccugg                                                   20


<210>  18869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18869
ggguaggcgc ucccgggagc                                                   20


<210>  18870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18870
cgggagcccg ccuggcccau                                                   20


<210>  18871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18871
cgggagcgcc uacccugagu                                                   20


<210>  18872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18872
acacucccgc guggggccgg                                                   20


<210>  18873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18873
cgcguggggc cggacaugcu                                                   20


<210>  18874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18874
ccacguugga uggggguggc                                                   20


<210>  18875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18875
acguuggaug gggguggcug                                                   20


<210>  18876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18876
gccaccccca uccaacgugg                                                   20


<210>  18877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18877
cguuuucagc ugcgugaaca                                                   20


<210>  18878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18878
uugagaacua uccucuggac                                                   20


<210>  18879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18879
augagguaaa acgcaguggc                                                   20


<210>  18880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18880
ggacguaggg ccggaauuuu                                                   20


<210>  18881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18881
ccuguauuau ugaugcugaa                                                   20


<210>  18882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18882
gcacacgggg agugggcuuc                                                   20


<210>  18883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18883
ccgugugcag aggaagacag                                                   20


<210>  18884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18884
uuuccuugca ggaucauacc                                                   20


<210>  18885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18885
cgaccaaguc aaaacuggcc                                                   20


<210>  18886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18886
ucccgaccaa gucaaaacug                                                   20


<210>  18887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18887
gguguucaug ccuccucccg                                                   20


<210>  18888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18888
gugucaaaga aucgcugcac                                                   20


<210>  18889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18889
cugugcagau guguggggug                                                   20


<210>  18890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18890
cuuccagaca gcaucacccc                                                   20


<210>  18891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18891
ucacuuccag acagcaucac                                                   20


<210>  18892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18892
aucauuuacc acugugcccu                                                   20


<210>  18893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18893
gaggccugga gcgccuccug                                                   20


<210>  18894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18894
gagggcacag ugguaaauga                                                   20


<210>  18895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18895
aggccucuga gggcacagug                                                   20


<210>  18896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18896
ugcucucuga gcagcucucc                                                   20


<210>  18897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18897
cugagcagcu cucccgccug                                                   20


<210>  18898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18898
gagcagcucu cccgccugga                                                   20


<210>  18899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18899
gagagcagga ggcgcuccag                                                   20


<210>  18900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18900
cccgccugga ugcagaaucg                                                   20


<210>  18901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18901
cgccuggaug cagaaucgcu                                                   20


<210>  18902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18902
gcuugaccag cgauucugca                                                   20


<210>  18903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18903
guccacacuc agcuugacca                                                   20


<210>  18904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18904
gggccugaug cucaccugca                                                   20


<210>  18905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18905
ccugcaugua cacaggugag                                                   20


<210>  18906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18906
ccuguguaca ugcaggugag                                                   20


<210>  18907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18907
cuugaacagg acuugggcug                                                   20


<210>  18908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18908
ugccucccuu gaacaggacu                                                   20


<210>  18909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18909
cucaagggac cucgacuagg                                                   20


<210>  18910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18910
agggaccucg acuaggugcc                                                   20


<210>  18911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18911
acuaggugcc cucugauuuc                                                   20


<210>  18912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18912
gauuucacac uucugguguu                                                   20


<210>  18913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18913
ggagccccca gggcuggagu                                                   20


<210>  18914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18914
agagccuuuc uugcaaggug                                                   20


<210>  18915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18915
agcccugggg gcuccagagc                                                   20


<210>  18916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18916
ucccaugugg cugagcuggg                                                   20


<210>  18917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18917
gccacauggg augagugacc                                                   20


<210>  18918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18918
agggacucac uggaccccug                                                   20


<210>  18919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18919
cuggaccccu guguacaaag                                                   20


<210>  18920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18920
guagacagug cuuuguacac                                                   20


<210>  18921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18921
auacaaccca auaggcucug                                                   20


<210>  18922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18922
uuuccuguaa caaaaguguu                                                   20


<210>  18923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18923
cugucggggg cugcaggauu                                                   20


<210>  18924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18924
auagcaacaa ucacugacuc                                                   20


<210>  18925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18925
gccguuagcu ucccuagaac                                                   20


<210>  18926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18926
agcaacagcg ccaggggauc                                                   20


<210>  18927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18927
ggguuccacu ggcgagcugg                                                   20


<210>  18928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18928
ccaguggaac ccugagccaa                                                   20


<210>  18929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18929
gguguagcgu ugaccaguuc                                                   20


<210>  18930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18930
ccugagggcu cagggacagu                                                   20


<210>  18931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18931
ugagggcuca gggacaguac                                                   20


<210>  18932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18932
ggagagaugg gcaggcacug                                                   20


<210>  18933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18933
gggacaguac cuggcaguug                                                   20


<210>  18934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18934
gggagggugg ggcagaagcc                                                   20


<210>  18935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18935
cagaggcugg ucauuccugc                                                   20


<210>  18936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18936
cuguacaggc uucugcccca                                                   20


<210>  18937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18937
ucacuguaca ggcuucugcc                                                   20


<210>  18938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18938
uccucacugu acaggcuucu                                                   20


<210>  18939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18939
gccuggcugc cuaucgugag                                                   20


<210>  18940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18940
cgauaggcag ccaggcugag                                                   20


<210>  18941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18941
cacgauaggc agccaggcug                                                   20


<210>  18942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18942
ccucucacga uaggcagcca                                                   20


<210>  18943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18943
cacagccccg ugggcucccc                                                   20


<210>  18944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18944
caggcaccac ggccccccuc                                                   20


<210>  18945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18945
cccugcucac aggcaccacg                                                   20


<210>  18946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18946
ucacccugcu cacaggcacc                                                   20


<210>  18947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18947
ugccgcugcu ccucacccug                                                   20


<210>  18948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18948
aagaugcaug uguggguucc                                                   20


<210>  18949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18949
ccugcucugg aaguggguua                                                   20


<210>  18950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18950
ggaagugggu uaggagcuug                                                   20


<210>  18951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18951
uaacccacuu ccagagcagg                                                   20


<210>  18952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18952
aggacaaggg ccccugauuu                                                   20


<210>  18953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18953
caggccucag uccuggcgac                                                   20


<210>  18954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18954
ggccucaguc cuggcgacau                                                   20


<210>  18955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18955
guccuggcga caugguggau                                                   20


<210>  18956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18956
agauccacca ugucgccagg                                                   20


<210>  18957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18957
ccaaucaggg uggccagugg                                                   20


<210>  18958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18958
aaucagggug gccagugggg                                                   20


<210>  18959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18959
ccacuggcca cccugauugg                                                   20


<210>  18960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18960
agagcauacu cagguggacc                                                   20


<210>  18961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18961
ugagaaaagc caaauggcuc                                                   20


<210>  18962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18962
gguggaccuu gcuccacugu                                                   20


<210>  18963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18963
acuguuugac cagaugaggc                                                   20


<210>  18964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18964
ucuggucaaa caguggagca                                                   20


<210>  18965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18965
aaaagaaaag aaaaaaaaaa                                                   20


<210>  18966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18966
aucucaaaaa gaaaagaaaa                                                   20


<210>  18967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18967
agccugggug acaagggaaa                                                   20


<210>  18968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18968
gcucacugca accuccgccu                                                   20


<210>  18969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18969
cugcaaccuc cgccucccgg                                                   20


<210>  18970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18970
gccucccggg uucaagugau                                                   20


<210>  18971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18971
cggguucaag ugauucuccu                                                   20


<210>  18972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18972
ugccucagcc ucccuaguag                                                   20


<210>  18973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18973
gccucccuag uagcugggau                                                   20


<210>  18974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18974
cuaguagcug ggauuacagg                                                   20


<210>  18975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18975
acuaaaaaca caaaaauuag                                                   20


<210>  18976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18976
aacuccugaa cucaagugau                                                   20


<210>  18977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18977
ugaacucaag ugauccaccc                                                   20


<210>  18978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18978
agugauccac ccuccuuggc                                                   20


<210>  18979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18979
uuggccuccc aaagugcugg                                                   20


<210>  18980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18980
caaagugcug ggauugcagg                                                   20


<210>  18981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18981
cgccugcaau cccagcacuu                                                   20


<210>  18982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18982
gcaucguucu ucagucccca                                                   20


<210>  18983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18983
cugagcacca cugcgacugg                                                   20


<210>  18984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18984
gugagcauau ggggacugaa                                                   20


<210>  18985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18985
cugugcccgu cugccagucg                                                   20


<210>  18986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18986
ccaccuagca uugggcccac                                                   20


<210>  18987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18987
aaagagugug gugcacgccu                                                   20


<210>  18988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18988
uuggagcacu cgccaccuag                                                   20


<210>  18989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18989
ccagacgcca cagggaggca                                                   20


<210>  18990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18990
agacgccaca gggaggcacc                                                   20


<210>  18991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18991
cuguggcguc uggagagcgg                                                   20


<210>  18992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18992
cagcugacca cagauuucuc                                                   20


<210>  18993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18993
cuguggagca gugucuucag                                                   20


<210>  18994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18994
guggagcagu gucuucagag                                                   20


<210>  18995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18995
acagagagaa aucugugguc                                                   20


<210>  18996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18996
gaagacacug cuccacagag                                                   20


<210>  18997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18997
cccagcagug gcauggcagc                                                   20


<210>  18998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18998
acccgcccgc agacccucgc                                                   20


<210>  18999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  18999
uggcucuacc cgcccgcaga                                                   20


<210>  19000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19000
caggugcucc uggcucuacc                                                   20


<210>  19001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19001
guuacacacg gcuggcaugu                                                   20


<210>  19002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19002
ucagugcaca caugccagcc                                                   20


<210>  19003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19003
gggggcgugu uucaggaucu                                                   20


<210>  19004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19004
cugcuucuuc ccuaaccaga                                                   20


<210>  19005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19005
cgcugcuucu ucccuaacca                                                   20


<210>  19006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19006
acaaacaucc cuauguguuc                                                   20


<210>  19007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19007
uuuguaacau ccuucccgcu                                                   20


<210>  19008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19008
ucuuaggagu ucuggucccu                                                   20


<210>  19009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19009
uaggaguucu ggucccuaca                                                   20


<210>  19010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19010
uaagaggagu uugaaagcua                                                   20


<210>  19011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19011
cacgcccugu agggaccaga                                                   20


<210>  19012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19012
ucuuaggagu ucuggucccu                                                   20


<210>  19013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19013
uaggaguucu ggucccuaca                                                   20


<210>  19014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19014
uaagaggagu uugaaagcua                                                   20


<210>  19015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19015
cacacccugu agggaccaga                                                   20


<210>  19016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19016
gcacaggccc ugggcuccca                                                   20


<210>  19017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19017
acgagcuaga cagaggaagg                                                   20


<210>  19018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19018
uggaggcagg cugcucggca                                                   20


<210>  19019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19019
gucuagcucg uggaggcagg                                                   20


<210>  19020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19020
aaauucguac uccaguugcu                                                   20


<210>  19021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19021
aguugcuuag gcucugacuu                                                   20


<210>  19022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19022
gacuuucccc acuuggaaag                                                   20


<210>  19023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19023
cggccgaggg ucccucccag                                                   20


<210>  19024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19024
gccgugaggg acuuuccaag                                                   20


<210>  19025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19025
cagcccugau uucacaucgg                                                   20


<210>  19026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19026
aauacugggg aaaaugccga                                                   20


<210>  19027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19027
gcgggcaggu ggggcagcug                                                   20


<210>  19028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19028
cacagcugcc ccaccugccc                                                   20


<210>  19029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19029
gaccugcguc ccuccuccca                                                   20


<210>  19030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19030
ucccaggauc aggaaaggcu                                                   20


<210>  19031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19031
caggaucagg aaaggcuuuc                                                   20


<210>  19032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19032
ggcuucacaa ggaaagccuu                                                   20


<210>  19033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19033
gaugacuuug uucaugaugu                                                   20


<210>  19034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19034
ccgaugacuu uguucaugau                                                   20


<210>  19035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19035
ccuuauacac cacgguggcc                                                   20


<210>  19036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19036
auccccaucc cacaugcaac                                                   20


<210>  19037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19037
aggcuuuccc acuccauccc                                                   20


<210>  19038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19038
accuccaggc uuucccacuc                                                   20


<210>  19039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19039
gacuucccag cagauucgcc                                                   20


<210>  19040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19040
gcuggcgaau cugcugggaa                                                   20


<210>  19041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19041
uccgcuuuaa agcagcaaug                                                   20


<210>  19042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19042
gcuuuaaagc agcaaugccu                                                   20


<210>  19043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19043
ggcccccacc ccacccccgc                                                   20


<210>  19044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19044
ggcaccugcu ugcuccuugc                                                   20


<210>  19045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19045
uugcaggugu uucagacucu                                                   20


<210>  19046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19046
gcacagcacc gggcagucgu                                                   20


<210>  19047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19047
ccaacuucac gcagagggcc                                                   20


<210>  19048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19048
aacuucacgc agagggcccc                                                   20


<210>  19049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19049
gcgugaaguu ggagagggac                                                   20


<210>  19050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19050
acguggccau ggcgaccggg                                                   20


<210>  19051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19051
ccugcuucuu ugucagcgcg                                                   20


<210>  19052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19052
ugcuucuuug ucagcgcguc                                                   20


<210>  19053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19053
cugggucccu ggugcuggcc                                                   20


<210>  19054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19054
gggucccugg ugcuggcccc                                                   20


<210>  19055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19055
guguugacaa gggaaacggg                                                   20


<210>  19056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19056
uguuucauga uaagguuuug                                                   20


<210>  19057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19057
gccccaggga aguaaaaugc                                                   20


<210>  19058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19058
uuucuguacc ccugucagca                                                   20


<210>  19059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19059
cagaggggcc gguguauggc                                                   20


<210>  19060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19060
gaggggccgg uguauggcag                                                   20


<210>  19061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19061
gagaggcccu ggucagcaaa                                                   20


<210>  19062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19062
ugccauacac cggccccucu                                                   20


<210>  19063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19063
gcugcgaccc uccugccaua                                                   20


<210>  19064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19064
acagaaaggc cccucagcug                                                   20


<210>  19065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19065
cccaggcccu ccacagaaag                                                   20


<210>  19066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19066
ccucacccag gcccuccaca                                                   20


<210>  19067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19067
cuccccucac ccaggcccuc                                                   20


<210>  19068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19068
gcagacgucc cgcccacucg                                                   20


<210>  19069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19069
cgggcucugu guggcugggc                                                   20


<210>  19070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19070
guguggcugg gcuucuccug                                                   20


<210>  19071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19071
ugacacugcu ucucauuagc                                                   20


<210>  19072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19072
uuagcuuugg ucauugugcc                                                   20


<210>  19073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19073
aucgcccucu cggggaaagg                                                   20


<210>  19074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19074
cggggaaagg cuuaaguaaa                                                   20


<210>  19075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19075
gggaaaggcu uaaguaaaga                                                   20


<210>  19076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19076
uggcagccag caucuggggg                                                   20


<210>  19077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19077
uguggucugu cuuggggaag                                                   20


<210>  19078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19078
aagcagcaca guuguccugg                                                   20


<210>  19079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19079
gcccucacug cauuggagca                                                   20


<210>  19080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19080
cugcauugga gcagggcuag                                                   20


<210>  19081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19081
aaugcaguga gggcagagcc                                                   20


<210>  19082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19082
acuagcccug cuccaaugca                                                   20


<210>  19083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19083
ugugcagcgc ugguggccgg                                                   20


<210>  19084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19084
ccuggccugg cuccugugca                                                   20


<210>  19085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19085
gcagcacuca ccuggccugg                                                   20


<210>  19086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19086
auuccugcaa cccuuggcug                                                   20


<210>  19087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19087
accuccauuc cugcaacccu                                                   20


<210>  19088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19088
agcugcauca gcgccuccac                                                   20


<210>  19089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19089
gcucgcucuc caggcucccu                                                   20


<210>  19090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19090
cucuccaggc ucccuggacc                                                   20


<210>  19091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19091
ccaggcuccc uggaccccuu                                                   20


<210>  19092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19092
aggcucccug gaccccuuug                                                   20


<210>  19093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19093
cuggaccccu uuguagacug                                                   20


<210>  19094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19094
ugaaacaguc uacaaagggg                                                   20


<210>  19095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19095
ccugaaacag ucuacaaagg                                                   20


<210>  19096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19096
caggugagga cagggaggca                                                   20


<210>  19097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19097
ccugggaguu ccucuccuga                                                   20


<210>  19098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19098
cuguccucac cugggaguuc                                                   20


<210>  19099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19099
uuugccggcc uuuuuccuua                                                   20


<210>  19100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19100
ugcaccagcc ucccacaugu                                                   20


<210>  19101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19101
cacaugucau cagcaggaug                                                   20


<210>  19102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19102
agcuugccca uccugcugau                                                   20


<210>  19103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19103
aucugguguc uguagaaguc                                                   20


<210>  19104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19104
ucuaucuggu gucuguagaa                                                   20


<210>  19105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19105
uccucuaucu ggugucugua                                                   20


<210>  19106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19106
accgcagggc cuuccagucu                                                   20


<210>  19107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19107
agcacagacu ggaaggcccu                                                   20


<210>  19108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19108
gcagguggug accuugugga                                                   20


<210>  19109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19109
caccauggcg cucagcaggu                                                   20


<210>  19110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19110
cccaccaugg cgcucagcag                                                   20


<210>  19111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19111
cagucucucc caccauggcg                                                   20


<210>  19112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19112
ggccccagcu gccgccucac                                                   20


<210>  19113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19113
accgagccag cuuggucccu                                                   20


<210>  19114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19114
guggaggcag ggcacaaggg                                                   20


<210>  19115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19115
gccauguggc agaagugcuc                                                   20


<210>  19116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19116
uuguggcagu ggccaggcag                                                   20


<210>  19117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19117
cugccuggcc acugccacaa                                                   20


<210>  19118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19118
gccccaccag gacugcagac                                                   20


<210>  19119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19119
ggcucagccc caccaggacu                                                   20


<210>  19120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19120
ugcuuucugg aaggccucag                                                   20


<210>  19121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19121
ugauagucac cugcugguug                                                   20


<210>  19122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19122
ugcaucuggg ccagaagucc                                                   20


<210>  19123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19123
cuccugcagg cuggcuguug                                                   20


<210>  19124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19124
ugcaggcugg cuguuggccc                                                   20


<210>  19125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19125
gcuguccugc aguagaaggu                                                   20


<210>  19126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19126
cggcaccuuc uacugcagga                                                   20


<210>  19127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19127
cugguggggu gugcaugcca                                                   20


<210>  19128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19128
cuucucucuu uucuucucag                                                   20


<210>  19129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19129
cuuuucuucu caggauuuaa                                                   20


<210>  19130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19130
uuucuucuca ggauuuaaaa                                                   20


<210>  19131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19131
ggauuuaaaa uuuaauuaua                                                   20


<210>  19132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19132
uuacugauau aauuaaauuu                                                   20


<210>  19133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19133
uucuaugccc guguaaagua                                                   20


<210>  19134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19134
cucuccugua gccacuggca                                                   20


<210>  19135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19135
ccuguagcca cuggcauagc                                                   20


<210>  19136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19136
uguagccacu ggcauagccc                                                   20


<210>  19137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19137
ugagcacccg cugacauuuc                                                   20


<210>  19138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19138
ggagggcuau gccaguggcu                                                   20


<210>  19139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19139
acaucccagu caccuuguga                                                   20


<210>  19140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19140
cuacauccca gucaccuugu                                                   20


<210>  19141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19141
guccugcugu ggccaccugc                                                   20


<210>  19142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19142
ccugcagccc cuccuccucg                                                   20


<210>  19143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19143
uccucgggca cagacgacug                                                   20


<210>  19144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19144
ucgggcacag acgacugucg                                                   20


<210>  19145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19145
ggcacagacg acugucguuc                                                   20


<210>  19146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19146
acccaccagu cagggacagc                                                   20


<210>  19147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19147
cugucacuca gcugagaagg                                                   20


<210>  19148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19148
gcugagaagg ccagcccucc                                                   20


<210>  19149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19149
gcugagugac agggaggcug                                                   20


<210>  19150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19150
cuggcuguga gcagccucca                                                   20


<210>  19151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19151
cagccaggga gggcuggccu                                                   20


<210>  19152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19152
acugugucca gagacauggg                                                   20


<210>  19153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19153
ggacacagug gaggcugcuc                                                   20


<210>  19154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19154
cacuccuguu ccuugcuagc                                                   20


<210>  19155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19155
uguuccuugc uagcccuggg                                                   20


<210>  19156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19156
uaggcagacg ccaccccagg                                                   20


<210>  19157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19157
auggaugcau gcccuaagag                                                   20


<210>  19158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19158
uagggcaugc auccauggag                                                   20


<210>  19159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19159
gugacacucu uagggcaugc                                                   20


<210>  19160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19160
gacaaaacac agcucaguga                                                   20


<210>  19161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19161
cucggucaac agcaaagcuu                                                   20


<210>  19162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19162
cggucaacag caaagcuugg                                                   20


<210>  19163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19163
gucaacagca aagcuuggug                                                   20


<210>  19164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19164
gucacuaaca gugccaagac                                                   20


<210>  19165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19165
ugacuaaaag gggucaccgu                                                   20


<210>  19166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19166
ccugacuaaa aggggucacc                                                   20


<210>  19167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19167
ucggagacug ccccacggcc                                                   20


<210>  19168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19168
gaugagcaca gaucugcacu                                                   20


<210>  19169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19169
gacagggccg uggggcaguc                                                   20


<210>  19170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19170
uauccccagg ccaggucccu                                                   20


<210>  19171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19171
uguuugcagg cccagaggag                                                   20


<210>  19172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19172
gggccugcaa acaggaggcu                                                   20


<210>  19173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19173
ucugggccug caaacaggag                                                   20


<210>  19174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19174
uacaucagca gcagcccggc                                                   20


<210>  19175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19175
caaauccagc uccuacauca                                                   20


<210>  19176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19176
gcuugccgac uggcugugag                                                   20


<210>  19177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19177
cagccagucg gcaagcagag                                                   20


<210>  19178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19178
ucucacagcc agucggcaag                                                   20


<210>  19179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19179
gcuuccucag cccuagaggc                                                   20


<210>  19180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19180
gcccuagagg cgagccaggc                                                   20


<210>  19181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19181
agggcugagg aagcagagcc                                                   20


<210>  19182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19182
ccucuagggc ugaggaagca                                                   20


<210>  19183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19183
acuuaccaca uucaauaccc                                                   20


<210>  19184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19184
gugcaggugc ugccuugaga                                                   20


<210>  19185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19185
aggcagcacc ugcacagagu                                                   20


<210>  19186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19186
ccuauguggc agcuggggag                                                   20


<210>  19187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19187
uauguggcag cuggggagca                                                   20


<210>  19188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19188
ccagcugcca cauaggagag                                                   20


<210>  19189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19189
gcugcucccc agcugccaca                                                   20


<210>  19190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19190
cguauguggg cagcauacaa                                                   20


<210>  19191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19191
cccucacgua ugugggcagc                                                   20


<210>  19192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19192
cuuucagcuc ccccucacgu                                                   20


<210>  19193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19193
ucugagcagc cucugccagg                                                   20


<210>  19194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19194
gagcagccuc ugccaggccu                                                   20


<210>  19195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19195
gaggaggggc ucccuuucag                                                   20


<210>  19196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19196
gccaggccug uaugaggcuu                                                   20


<210>  19197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19197
uacaggccug gcagaggcug                                                   20


<210>  19198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19198
caacagaggc cucccccagc                                                   20


<210>  19199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19199
guugggagcu ggugggaaaa                                                   20


<210>  19200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19200
cccagccagg accaccucgu                                                   20


<210>  19201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19201
uccucguggc ggggcagcag                                                   20


<210>  19202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19202
uggcggggca gcaggagcgg                                                   20


<210>  19203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19203
ugcugccccg ccacgaggac                                                   20


<210>  19204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19204
aacaucggac cccuuucuac                                                   20


<210>  19205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19205
ucaaacaucg gaccccuuuc                                                   20


<210>  19206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19206
uguuucucau ccuagcuuuu                                                   20


<210>  19207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19207
uccuagcuuu uuccuggaaa                                                   20


<210>  19208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19208
uucccaaacc uucuagcggg                                                   20


<210>  19209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19209
gaacuguugg cugcucccca                                                   20


<210>  19210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19210
ccacccgccu cccgccuccc                                                   20


<210>  19211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19211
cgccuccccc gcagguuaug                                                   20


<210>  19212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19212
cccgcagguu augucagcag                                                   20


<210>  19213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19213
gagacagcag uaucacaggc                                                   20


<210>  19214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19214
gagcugcuga cauaaccugc                                                   20


<210>  19215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19215
guuuuacauu cacaguguua                                                   20


<210>  19216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19216
acauagaguu ugucuuccuc                                                   20


<210>  19217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19217
auguugagcc cagcgauaug                                                   20


<210>  19218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19218
uguuuacgac gugaucuaaa                                                   20


<210>  19219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19219
gaacaccccg cucuggcagu                                                   20


<210>  19220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19220
ggcaguaggu gucccccacc                                                   20


<210>  19221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19221
ggagaugaau augagcucau                                                   20


<210>  19222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19222
ggagcacaca ggcaggucuu                                                   20


<210>  19223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19223
uauucaucuc cggagcacac                                                   20


<210>  19224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19224
uuaguaaaaa ugacuucacc                                                   20


<210>  19225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19225
caagacggag augcauggcc                                                   20


<210>  19226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19226
agacggagau gcauggccuc                                                   20


<210>  19227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19227
gucuugagag gugugugugu                                                   20


<210>  19228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19228
aagagugccc gugucgguuc                                                   20


<210>  19229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19229
uagaggccau gcaucuccgu                                                   20


<210>  19230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19230
uucauugccc acuaggaucc                                                   20


<210>  19231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19231
auaucagcuc ucugcagaag                                                   20


<210>  19232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19232
cugcagaagg gaggaagacu                                                   20


<210>  19233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19233
gcagaaggga ggaagacuuu                                                   20


<210>  19234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19234
cuucugcaga gagcugauau                                                   20


<210>  19235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19235
ccacagccca cccccaaaac                                                   20


<210>  19236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19236
cuuccgcugc gggcccagcu                                                   20


<210>  19237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19237
gcugggcccg cagcggaagg                                                   20


<210>  19238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19238
uuguuacugu ccacccucau                                                   20


<210>  19239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19239
uuucugccag cgcauguguc                                                   20


<210>  19240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19240
agacacccag aauguagcau                                                   20


<210>  19241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19241
gaugcuacau ucuggguguc                                                   20


<210>  19242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19242
cccccaucuu cauggagggg                                                   20


<210>  19243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19243
augaagaugg gggcgagggg                                                   20


<210>  19244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19244
gaaaugaccc ccuccaugaa                                                   20


<210>  19245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19245
gagccaauga acagcuccuc                                                   20


<210>  19246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19246
gagggcucug aaaugacccc                                                   20


<210>  19247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19247
uccucuugga gcugagauga                                                   20


<210>  19248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19248
ucuuggagcu gagaugagcc                                                   20


<210>  19249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19249
uggagcugag augagcccca                                                   20


<210>  19250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19250
aagaggagga gcuguucauu                                                   20


<210>  19251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19251
gcuccaagag gaggagcugu                                                   20


<210>  19252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19252
ucucagcucc aagaggagga                                                   20


<210>  19253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19253
acguggggcu caucucagcu                                                   20


<210>  19254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19254
ggacggauag uagacagcaa                                                   20


<210>  19255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19255
guguguggcc gccuggcagg                                                   20


<210>  19256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19256
cguugcgggg uggagugagg                                                   20


<210>  19257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19257
accccgcaac gggaggaagu                                                   20


<210>  19258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19258
cuccaccccg caacgggagg                                                   20


<210>  19259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19259
acccaccaga cacacagaac                                                   20


<210>  19260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19260
ugcuaccugu gagcauccuu                                                   20


<210>  19261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19261
cagguagcaa gagaagccug                                                   20


<210>  19262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19262
ucgggcuuug ucccuccccc                                                   20


<210>  19263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19263
cccgcuuccu cccucugcgg                                                   20


<210>  19264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19264
cucugcgggg aggacccggg                                                   20


<210>  19265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19265
gcggggagga cccgggacca                                                   20


<210>  19266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19266
ccgcagaggg aggaagcggg                                                   20


<210>  19267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19267
aagucuaccc uggccagcag                                                   20


<210>  19268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19268
agagggguca cguguaggag                                                   20


<210>  19269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19269
ggaggacagc uccaagucua                                                   20


<210>  19270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19270
uacacgugac cccucuggag                                                   20


<210>  19271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19271
cuccuacacg ugaccccucu                                                   20


<210>  19272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19272
agaucuuccu ucuucucacu                                                   20


<210>  19273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19273
caagaucuuc cuucuucuca                                                   20


<210>  19274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19274
gcagcucuca agaucuuccu                                                   20


<210>  19275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19275
aaggucccuc agcagcucuc                                                   20


<210>  19276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19276
ccaagguccc ucagcagcuc                                                   20


<210>  19277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19277
ggauggcuca gacgaggaca                                                   20


<210>  19278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19278
gacgaggaca cucgcuugcc                                                   20


<210>  19279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19279
ucugagccau ccugagcucu                                                   20


<210>  19280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19280
cuugccgggc cugggccucc                                                   20


<210>  19281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19281
ugggaaggag ggagcugcuc                                                   20


<210>  19282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19282
uucccaggag gcccaggccc                                                   20


<210>  19283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19283
cuccuuccca ggaggcccag                                                   20


<210>  19284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19284
gaaugccgca ugacaacuga                                                   20


<210>  19285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19285
ucccccaugu gccugucacg                                                   20


<210>  19286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19286
ggugcaguca aaggaacgcc                                                   20


<210>  19287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19287
guuguuucua agagcagagu                                                   20


<210>  19288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19288
uagaaacaac ugaggggaag                                                   20


<210>  19289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19289
gcucuuagaa acaacugagg                                                   20


<210>  19290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19290
cgcugcaauc ugggugguaa                                                   20


<210>  19291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19291
aaggcuggca guuaccaccc                                                   20


<210>  19292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19292
guaggcaggu ccacguuggc                                                   20


<210>  19293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19293
gacccaagug gggccuccuu                                                   20


<210>  19294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19294
uuguccaggu cucacugcuu                                                   20


<210>  19295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19295
cugcuuugca ccguggucag                                                   20


<210>  19296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19296
gaccacggug caaagcagug                                                   20


<210>  19297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19297
gcugacaguc ccucugacca                                                   20


<210>  19298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19298
agcucagcug acagucccuc                                                   20


<210>  19299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19299
ccuggagcca gcagggcugu                                                   20


<210>  19300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19300
aggggagcuc aagcucagcu                                                   20


<210>  19301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19301
cccaucacag cccugcuggc                                                   20


<210>  19302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19302
gggacucgcc caucacagcc                                                   20


<210>  19303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19303
gaagcauuca ggucugggug                                                   20


<210>  19304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19304
cagaagcauu caggucuggg                                                   20


<210>  19305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19305
ucaguccuuc ccuuugcucu                                                   20


<210>  19306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19306
cgucaguccu ucccuuugcu                                                   20


<210>  19307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19307
cacagcaaca acugaugguu                                                   20


<210>  19308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19308
ugaagcaaag caagccucac                                                   20


<210>  19309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19309
gcaaggucua gguucucaug                                                   20


<210>  19310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19310
agcucagcaa ggucuagguu                                                   20


<210>  19311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19311
uaagugcuuc uccagcaggg                                                   20


<210>  19312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19312
agcaggggca gaaacugucc                                                   20


<210>  19313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19313
auaaugccag auguuagcug                                                   20


<210>  19314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19314
ucccuggcua cagaaaacac                                                   20


<210>  19315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19315
caucugcagg gcaggaagac                                                   20


<210>  19316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19316
cacagcuccc aucugcaggg                                                   20


<210>  19317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19317
agcagcuccc acagcuccca                                                   20


<210>  19318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19318
agcagcucca gcagcuccca                                                   20


<210>  19319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19319
ggacuuggcc cauggcacug                                                   20


<210>  19320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19320
gugcugggcc ugaugaccug                                                   20


<210>  19321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19321
agucucugug cugggccuga                                                   20


<210>  19322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19322
cagggcccac cacccuucca                                                   20


<210>  19323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19323
uuggccauug acaccugcgu                                                   20


<210>  19324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19324
cagguaaccc ccaaagcagc                                                   20


<210>  19325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19325
gguguggccg gggcugcugu                                                   20


<210>  19326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19326
aagaagccuc ugcucagccc                                                   20


<210>  19327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19327
gcucagccca gcggggaugc                                                   20


<210>  19328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19328
gcccagcggg gaugcuucua                                                   20


<210>  19329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19329
ggacgagccu cucggaagcc                                                   20


<210>  19330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19330
uccggagcuu agaagcaucc                                                   20


<210>  19331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19331
cggaagccuu ggugauuggu                                                   20


<210>  19332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19332
gaagccuugg ugauuggugg                                                   20


<210>  19333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19333
ggugcagggu auuuagucaa                                                   20


<210>  19334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19334
gcaaacauug acuaaauacc                                                   20


<210>  19335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19335
gcugucugug ccaggagaga                                                   20


<210>  19336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19336
uggcacagac agcagagcag                                                   20


<210>  19337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19337
ccuggcacag acagcagagc                                                   20


<210>  19338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19338
ugcugccugc uccucuuggg                                                   20


<210>  19339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19339
ucuugggcac gugcgggggc                                                   20


<210>  19340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19340
ugggcacgug cgggggcccc                                                   20


<210>  19341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19341
gagcagggau agggaucagu                                                   20


<210>  19342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19342
gagaaagggg gcccccgcac                                                   20


<210>  19343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19343
ggcagacuga ucccuauccc                                                   20


<210>  19344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19344
aguggcaugc cccgccccaa                                                   20


<210>  19345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19345
cuaaaucugu cuccucauag                                                   20


<210>  19346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19346
ucauagguga caccgcucca                                                   20


<210>  19347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19347
uaggugacac cgcuccaggg                                                   20


<210>  19348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19348
agggcccccc aguggccucu                                                   20


<210>  19349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19349
ccuuucagag cuaccuaaau                                                   20


<210>  19350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19350
uuucagagcu accuaaauuc                                                   20


<210>  19351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19351
gaaaggagag gccacugggg                                                   20


<210>  19352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19352
gaagugacca gaauuuaggu                                                   20


<210>  19353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19353
auuucucuga agugaccaga                                                   20


<210>  19354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19354
cugguccagg uguggacagc                                                   20


<210>  19355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19355
gugugccagg cuguccacac                                                   20


<210>  19356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19356
ucuuucugaa auuaccagcc                                                   20


<210>  19357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19357
ugagugggcu uugcaguccc                                                   20


<210>  19358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19358
cgagggguuc accgcugcuu                                                   20


<210>  19359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19359
ccaugccacg gcagagcugc                                                   20


<210>  19360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19360
gccguggcau ggggagggac                                                   20


<210>  19361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19361
acacagccuu ccucuuccuc                                                   20


<210>  19362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19362
uccucaucgg agagcacacc                                                   20


<210>  19363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19363
ucggagagca cacccugucc                                                   20


<210>  19364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19364
gaugaggaag aggaaggcug                                                   20


<210>  19365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19365
ccgaugagga agaggaaggc                                                   20


<210>  19366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19366
gcaaggggac agggugugcu                                                   20


<210>  19367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19367
acgcaccacg caggggaagc                                                   20


<210>  19368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19368
ucugacuuac agugcuccac                                                   20


<210>  19369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19369
cccuggcuac uucccucauc                                                   20


<210>  19370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19370
ccucacccug gcuacuuccc                                                   20


<210>  19371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19371
acccgguacu caccucaccc                                                   20


<210>  19372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19372
acaugaugug acacagccaa                                                   20


<210>  19373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19373
guuggcugug ucacaucaug                                                   20


<210>  19374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19374
guccucgguu ggcuguguca                                                   20


<210>  19375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19375
gggaagccug caguggggcc                                                   20


<210>  19376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19376
ggccccacug caggcuuccc                                                   20


<210>  19377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19377
gcgagcccac gagucugguc                                                   20


<210>  19378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19378
cggaggaugc cuuuccucag                                                   20


<210>  19379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19379
ugggcucgcg gaggaugccu                                                   20


<210>  19380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19380
uggaccagac ucgugggcuc                                                   20


<210>  19381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19381
acccacagac acugucacgg                                                   20


<210>  19382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19382
uuugggaaac cauguggaca                                                   20


<210>  19383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19383
gcagccccag cagccuggcu                                                   20


<210>  19384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19384
agccacuugc ccaaaaggca                                                   20


<210>  19385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19385
guggcucaag ccacuugccc                                                   20


<210>  19386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19386
gggggggccc gccagugugg                                                   20


<210>  19387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19387
acccuacacc aggccuccag                                                   20


<210>  19388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19388
agguguccug gucgggggug                                                   20


<210>  19389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19389
cagguccaca gggcccaccc                                                   20


<210>  19390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19390
agugaugccc ugacccugac                                                   20


<210>  19391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19391
gccuccagug augcccugac                                                   20


<210>  19392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19392
augcuugguc aggcagcuac                                                   20


<210>  19393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19393
ggaccagccu guccuagcag                                                   20


<210>  19394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19394
ggacagccca cccgcccaac                                                   20


<210>  19395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19395
uggccccaau ugcucugggg                                                   20


<210>  19396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19396
ggggaagucc aggcuccgga                                                   20


<210>  19397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19397
ggagccugcc caggggcccc                                                   20


<210>  19398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19398
ggagccugga cuuccccaga                                                   20


<210>  19399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19399
acgugguucu cugccuucac                                                   20


<210>  19400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19400
gccuucaccc aagcccugaa                                                   20


<210>  19401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19401
ucagcugcca aauccccacc                                                   20


<210>  19402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19402
gcugccaaau ccccacccau                                                   20


<210>  19403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19403
ccacugcugc uccuggaagg                                                   20


<210>  19404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19404
uggaaggugc cccucagugg                                                   20


<210>  19405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19405
gugggacgcc caccuccucu                                                   20


<210>  19406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19406
ucucugggcu ucuguguuug                                                   20


<210>  19407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19407
cugggcuucu guguuuggga                                                   20


<210>  19408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19408
gggcuucugu guuugggagc                                                   20


<210>  19409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19409
caaacacaga agcccagaga                                                   20


<210>  19410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19410
gcauuucugg guggauuuuc                                                   20


<210>  19411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19411
uccugcucag cauuucuggg                                                   20


<210>  19412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19412
cauccugcuc agcauuucug                                                   20


<210>  19413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19413
uuauuuagaa gggauggagg                                                   20


<210>  19414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19414
aucccuucua aauaaugagg                                                   20


<210>  19415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19415
cuaggccucc aucccuucua                                                   20


<210>  19416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19416
ggcuagaagc augcucccua                                                   20


<210>  19417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19417
ugccgaggcc ugaccugccc                                                   20


<210>  19418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19418
gcaggagcug ucccuggugc                                                   20


<210>  19419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19419
cucaggugcu gcugguugac                                                   20


<210>  19420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19420
ggugcugcug guugaccagc                                                   20


<210>  19421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19421
ggcccuagga gaccccguag                                                   20


<210>  19422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19422
uagggccaga ggcuggucaa                                                   20


<210>  19423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19423
gucgcuacgg ggucuccuag                                                   20


<210>  19424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19424
uaccuuggca aagcugcaug                                                   20


<210>  19425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19425
ccagcagggg acagaugugg                                                   20


<210>  19426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19426
caggcaggag cagcugggug                                                   20


<210>  19427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19427
ugccugggag gguccccaca                                                   20


<210>  19428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19428
cauuggaggu cagugugagg                                                   20


<210>  19429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19429
aaugugagga caagaaccag                                                   20


<210>  19430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19430
cacugaccuc caaugugagg                                                   20


<210>  19431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19431
gccucgggaa aggccaugga                                                   20


<210>  19432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19432
ggaaaggcca uggagcuugc                                                   20


<210>  19433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19433
auggccuuuc ccgaggcaga                                                   20


<210>  19434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19434
caugugcacu gagccuggga                                                   20


<210>  19435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19435
gugcacaugg gaggcccugg                                                   20


<210>  19436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19436
ucccaggcuc agugcacaug                                                   20


<210>  19437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19437
cuucccaggc ucagugcaca                                                   20


<210>  19438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19438
aacccucucu ucccaggcuc                                                   20


<210>  19439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19439
acuccaaccc ucucuuccca                                                   20


<210>  19440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19440
aggcagcauu cccaggguaa                                                   20


<210>  19441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19441
cugcgcccac uggaacucgg                                                   20


<210>  19442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19442
ggcaggcagg gguguaggug                                                   20


<210>  19443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19443
ucuagagccg uccggugggg                                                   20


<210>  19444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19444
agagccgucc ggugggggcc                                                   20


<210>  19445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19445
agaggaggca ccuacacccc                                                   20


<210>  19446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19446
aagguggauu uguggaaggg                                                   20


<210>  19447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19447
acccccuucc acaaauccac                                                   20


<210>  19448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19448
acgugcccuc uacccccuuc                                                   20


<210>  19449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19449
ccaggguucu gggagggcug                                                   20


<210>  19450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19450
cagaacccug gggaggucau                                                   20


<210>  19451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19451
acaacagggg uaacaggauc                                                   20


<210>  19452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19452
ccuccacaac agggguaaca                                                   20


<210>  19453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19453
ccacuaaccu guuuccucac                                                   20


<210>  19454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19454
gcauggaccu uagucauguc                                                   20


<210>  19455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19455
agcgacucag cauggaccuu                                                   20


<210>  19456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19456
cggcacaagg gguaagcaga                                                   20


<210>  19457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19457
uggcaucucc cggcacaagg                                                   20


<210>  19458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19458
cagcaucucu uggcaucucc                                                   20


<210>  19459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19459
gcccuuggag ucauggcuac                                                   20


<210>  19460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19460
aagggcagag guggggcugg                                                   20


<210>  19461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19461
ccggggaggg ccgaacccug                                                   20


<210>  19462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19462
ccggugaggu cagggaccgg                                                   20


<210>  19463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19463
ggaacagggu ucggcccucc                                                   20


<210>  19464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19464
ucaggaacag gguucggccc                                                   20


<210>  19465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19465
aggaagcccu ggcuccucag                                                   20


<210>  19466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19466
ucuaggaagc ccuggcuccu                                                   20


<210>  19467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19467
uucaucugca ggcacuccac                                                   20


<210>  19468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19468
acagagcucu cugugccagc                                                   20


<210>  19469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19469
guggagugcc ugcagaugaa                                                   20


<210>  19470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19470
cugugccagc ccccagcacg                                                   20


<210>  19471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19471
gugccagccc ccagcacgga                                                   20


<210>  19472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19472
gugcuggggg cuggcacaga                                                   20


<210>  19473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19473
acuaagguca gcccuccgug                                                   20


<210>  19474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19474
acucgacuaa ggucagcccu                                                   20


<210>  19475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19475
ugaggcccag auggaaggga                                                   20


<210>  19476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19476
ggagacauca ucccuacugc                                                   20


<210>  19477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19477
uggggcugau gguggggcca                                                   20


<210>  19478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19478
gcacccccua cacugggucc                                                   20


<210>  19479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19479
gaguuccuca cacaucccug                                                   20


<210>  19480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19480
gaggggucuc ugcacccccu                                                   20


<210>  19481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19481
cacaucccug gggcccuccc                                                   20


<210>  19482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19482
ccauacacuu ccuauccuga                                                   20


<210>  19483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19483
ugcccgcagu caggauagga                                                   20


<210>  19484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19484
cucuugcccg cagucaggau                                                   20


<210>  19485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19485
ggggaaggac agggcagggg                                                   20


<210>  19486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19486
caggggaagg acagggcagg                                                   20


<210>  19487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19487
gucccaccuc caaggugccu                                                   20


<210>  19488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19488
aaggugccuc agaggacagc                                                   20


<210>  19489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19489
gaggacagca ggggcagcgg                                                   20


<210>  19490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19490
gaggcaccuu ggagguggga                                                   20


<210>  19491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19491
gcccgcugcc ccugcugucc                                                   20


<210>  19492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19492
gccucugccc gcugccccug                                                   20


<210>  19493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19493
ucauuccagg cucagcugcc                                                   20


<210>  19494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19494
uuccaggcuc agcugcccuu                                                   20


<210>  19495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19495
gcugcccuuc uuggggcagc                                                   20


<210>  19496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19496
ggugugggcu gccccaagaa                                                   20


<210>  19497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19497
cagguguggg cugccccaag                                                   20


<210>  19498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19498
ugcaguuggu caggccugag                                                   20


<210>  19499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19499
ggccugacca acugcaggag                                                   20


<210>  19500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19500
ucaggccuga ccaacugcag                                                   20


<210>  19501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19501
gcugaccaca guggcauuua                                                   20


<210>  19502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19502
acagagcccu gccugacaug                                                   20


<210>  19503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19503
guggagccca cggcaccugu                                                   20


<210>  19504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19504
gggcagaacc cccaggccac                                                   20


<210>  19505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19505
gguuccgguu ccgcugcauc                                                   20


<210>  19506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19506
cggcaggcug ugguccuccg                                                   20


<210>  19507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19507
gcaggcugug guccuccggc                                                   20


<210>  19508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19508
ggccagccug ggggcaucuc                                                   20


<210>  19509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19509
gucccucagc cccacagggg                                                   20


<210>  19510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19510
gccccacagg ggccugcccc                                                   20


<210>  19511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19511
agccccgucu ccgcacgcug                                                   20


<210>  19512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19512
aggcccaggc ugcggggcag                                                   20


<210>  19513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19513
gcacgcugug ccgaaucugg                                                   20


<210>  19514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19514
cugcguaccc agacugugcc                                                   20


<210>  19515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19515
ucccaggagu gcccuguggc                                                   20


<210>  19516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19516
ugggaagagc cacgggcaug                                                   20


<210>  19517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19517
cccuggcuug cugggcugau                                                   20


<210>  19518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19518
ugugucucaa acagagcuca                                                   20


<210>  19519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19519
aacagagcuc accuuugcca                                                   20


<210>  19520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19520
guuugagaca caggagggaa                                                   20


<210>  19521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19521
ccuuugccau cacugcuguc                                                   20


<210>  19522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19522
ccggccggug ccagaggccc                                                   20


<210>  19523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19523
ggcaccggcc ggugaggaca                                                   20


<210>  19524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19524
gggcagggcc uggcucugac                                                   20


<210>  19525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19525
gaccaacccg ggcuuccagu                                                   20


<210>  19526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19526
agcccccagg cgcccugggc                                                   20


<210>  19527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19527
ugcuccagcc cccaggcgcc                                                   20


<210>  19528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19528
uuuugcuucu cuugcuccag                                                   20


<210>  19529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19529
caagaacccc aaacccccac                                                   20


<210>  19530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19530
uggguguccu gguccugggg                                                   20


<210>  19531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19531
gaaggccccu gccuucugaa                                                   20


<210>  19532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19532
cucagaaggc cccugccuuc                                                   20


<210>  19533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19533
gccuccucgu cgcucguccu                                                   20


<210>  19534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19534
ucgucgcucg uccucucugu                                                   20


<210>  19535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19535
ucgcucgucc ucucuguuuc                                                   20


<210>  19536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19536
uccucucugu uucucccacc                                                   20


<210>  19537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19537
cuguuucucc caccuuuugc                                                   20


<210>  19538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19538
guuucuccca ccuuuugccc                                                   20


<210>  19539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19539
caccuuuugc ccccuuucuc                                                   20


<210>  19540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19540
uugccuguuc ccacccgagg                                                   20


<210>  19541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19541
ggugggaaca ggcaaggaga                                                   20


<210>  19542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19542
uggccugcgu gagccggggc                                                   20


<210>  19543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19543
cgcaggccaa gagggggccu                                                   20


<210>  19544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19544
ccgccgccca ggcggaucgg                                                   20


<210>  19545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19545
caccgccgcc caggcggauc                                                   20


<210>  19546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19546
cggcccugcc ucucaccgcc                                                   20


<210>  19547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19547
ccgcaauauu gauggcccgu                                                   20


<210>  19548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19548
guugcuaugg aaacgugaca                                                   20


<210>  19549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19549
aaauggggcc uacaucugac                                                   20


<210>  19550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19550
acgcucaaaa uggggccuac                                                   20


<210>  19551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19551
aaggcagcuc cacgcucaaa                                                   20


<210>  19552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19552
cucgaaggca gcuccacgcu                                                   20


<210>  19553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19553
cgcucgcucg aaggcagcuc                                                   20


<210>  19554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19554
cgcccauggu gcguggggcc                                                   20


<210>  19555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19555
cugagcgcgc ucucucaccc                                                   20


<210>  19556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19556
gcgagggccc cggcccggcc                                                   20


<210>  19557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19557
cucaccccac aggcgccucc                                                   20


<210>  19558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19558
caccccacag gcgccuccgg                                                   20


<210>  19559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19559
ccccacaggc gccuccggca                                                   20


<210>  19560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19560
ggcauggcgg cggccgaggg                                                   20


<210>  19561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19561
gccgccgcca ugccggaggc                                                   20


<210>  19562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19562
ugucucccca ggcggagaag                                                   20


<210>  19563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19563
ccaggcggag aagcaccggc                                                   20


<210>  19564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19564
gccuggggag acacgaggua                                                   20


<210>  19565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19565
gcguccgucc aguugcgggc                                                   20


<210>  19566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19566
ugcuggucug ggaggaguuc                                                   20


<210>  19567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19567
cagaccagca ugaggccgcg                                                   20


<210>  19568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19568
ucccagacca gcaugaggcc                                                   20


<210>  19569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19569
ucgaagaacu ccucccagac                                                   20


<210>  19570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19570
agcagaccaa gcgcaacgcc                                                   20


<210>  19571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19571
uacaccuugg cguugcgcuu                                                   20


<210>  19572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19572
ucgagaugac cggcgagcgc                                                   20


<210>  19573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19573
aagagcuugc uggccaucuu                                                   20


<210>  19574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19574
ccggucaucu cgaagagcuu                                                   20


<210>  19575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19575
cccagccugc gcucgccggu                                                   20


<210>  19576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19576
ucgcccagcc ugcgcucgcc                                                   20


<210>  19577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19577
cccaccugua cuggaagguc                                                   20


<210>  19578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19578
ugacuuucuu ggagcucuga                                                   20


<210>  19579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19579
aagaaaguca ggagcggccc                                                   20


<210>  19580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19580
gagucgggac gauguguggg                                                   20


<210>  19581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19581
gagcuccaag aaagucagga                                                   20


<210>  19582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19582
ucuggccggg uaugggcaga                                                   20


<210>  19583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19583
ggccggguau gggcagaacc                                                   20


<210>  19584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19584
ccccgugggg uucugcccau                                                   20


<210>  19585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19585
guuuccccac uuccccaaug                                                   20


<210>  19586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19586
uagacugguu uccugcccuu                                                   20


<210>  19587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19587
gcucuuagac ugguuuccug                                                   20


<210>  19588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19588
gcccagcacc agccccaccc                                                   20


<210>  19589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19589
caggacguau gggcggucug                                                   20


<210>  19590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19590
gaggcagcaa cacucauggu                                                   20


<210>  19591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19591
gagggacagu gcccagaccg                                                   20


<210>  19592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19592
ugguggugcc cacugaccuc                                                   20


<210>  19593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19593
cacccugcuc ccccauaggg                                                   20


<210>  19594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19594
cccauaggga ggcggcggcu                                                   20


<210>  19595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19595
cuauggggga gcagggugug                                                   20


<210>  19596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19596
ccaccaccaa gcucccaagc                                                   20


<210>  19597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19597
caagcucagc agggguuuca                                                   20


<210>  19598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19598
gcagggguuu caggggccua                                                   20


<210>  19599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19599
auuuccccaa ugacgcagua                                                   20


<210>  19600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19600
cuugcagucu caauuucccc                                                   20


<210>  19601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19601
uucucacuug cagucucaau                                                   20


<210>  19602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19602
gugcucugcg acuuggagca                                                   20


<210>  19603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19603
gcgacuugga gcauccacug                                                   20


<210>  19604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19604
aagucgcaga gcacugagcc                                                   20


<210>  19605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19605
guggaugcuc caagucgcag                                                   20


<210>  19606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19606
gccaugagcc ggugagcccc                                                   20


<210>  19607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19607
uggcagaggc ucaguggaug                                                   20


<210>  19608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19608
ccggcucaug gcagaggcuc                                                   20


<210>  19609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19609
ccuggugauu ucuggaaaua                                                   20


<210>  19610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19610
uucuucuucg caccguaagc                                                   20


<210>  19611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19611
accucuuucu ucuucgcacc                                                   20


<210>  19612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19612
cagcgugggg gcucccggcc                                                   20


<210>  19613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19613
cggccuggcc ccaccucugc                                                   20


<210>  19614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19614
gcuccugcua cauggcaggu                                                   20


<210>  19615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19615
ugcuacaugg caggugggcc                                                   20


<210>  19616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19616
ggccuucccu gcagguugcc                                                   20


<210>  19617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19617
cuggcugggu gguccccucc                                                   20


<210>  19618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19618
uagacgccaa caucucccug                                                   20


<210>  19619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19619
ggcacaggca aggucacagg                                                   20


<210>  19620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19620
ccgcaccugu gaccuugccu                                                   20


<210>  19621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19621
ccacacccaa aaccaucacc                                                   20


<210>  19622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19622
gugcaagacc cuccccacac                                                   20


<210>  19623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19623
cuccgugcaa gacccucccc                                                   20


<210>  19624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19624
ugcugccacc cucgcuccgu                                                   20


<210>  19625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19625
cccugcagcu uccagcucuu                                                   20


<210>  19626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19626
gcugccauuc ucccccugca                                                   20


<210>  19627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19627
cugcugccau ucucccccug                                                   20


<210>  19628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19628
ggcagcccca ggcccagccc                                                   20


<210>  19629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19629
ccggcagccc caggcccagc                                                   20


<210>  19630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19630
cauccuggaa gcugacaggc                                                   20


<210>  19631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19631
cucagcugcu ccaccuccgg                                                   20


<210>  19632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19632
gcugcuccac cuccggguca                                                   20


<210>  19633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19633
accuccgggu caggcaggug                                                   20


<210>  19634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19634
gggucaggca ggugagccug                                                   20


<210>  19635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19635
ccugccugac ccggaggugg                                                   20


<210>  19636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19636
gccccaggcu caccugccug                                                   20


<210>  19637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19637
cugccccagg cucaccugcc                                                   20


<210>  19638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19638
gccucucugc cccaggcuca                                                   20


<210>  19639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19639
cagccucucu gccccaggcu                                                   20


<210>  19640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19640
ggugcucuca gccucucugc                                                   20


<210>  19641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19641
cacaaguggc ucaggugcuc                                                   20


<210>  19642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19642
cccacaagug gcucaggugc                                                   20


<210>  19643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19643
ggcgaggagc cggccuccag                                                   20


<210>  19644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19644
ccugaggggg gcaguggggg                                                   20


<210>  19645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19645
ucgccugagg ggggcagugg                                                   20


<210>  19646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19646
agcacagcag aagggaaccc                                                   20


<210>  19647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19647
cacuagggcu ggggacuggg                                                   20


<210>  19648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19648
uccccacucc cacuagggcu                                                   20


<210>  19649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19649
caggcuggcg gucuguccgg                                                   20


<210>  19650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19650
gcuuucaguu gcguugauuu                                                   20


<210>  19651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19651
gaaaaaauca aaucaacgca                                                   20


<210>  19652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19652
uucaaggcuc agaaaaaauc                                                   20


<210>  19653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19653
gcacccuagg ucccggcuuu                                                   20


<210>  19654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19654
aacccaacau ccgucaugcu                                                   20


<210>  19655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19655
cgucgcaagc cagccgcuca                                                   20


<210>  19656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19656
gcccucacgu cgcaagccag                                                   20


<210>  19657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19657
caccucagcc cucacgucgc                                                   20


<210>  19658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19658
gaagauaccc aggcucacac                                                   20


<210>  19659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19659
uaguccugcu caggcaccug                                                   20


<210>  19660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19660
ggcaccuggu gaggaaggga                                                   20


<210>  19661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19661
ccaggugccu gagcaggacu                                                   20


<210>  19662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19662
gcgucccuuc cucaccaggu                                                   20


<210>  19663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19663
cacugcccuc ugcgucccuu                                                   20


<210>  19664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19664
ccucugacuc aggaauucac                                                   20


<210>  19665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19665
gacucaggaa uucacgggca                                                   20


<210>  19666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19666
ggaauucacg ggcaccaccu                                                   20


<210>  19667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19667
cuggcuggcu cugguuggug                                                   20


<210>  19668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19668
gguugguguc uggccagguu                                                   20


<210>  19669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19669
ucagaguccc aggggagggu                                                   20


<210>  19670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19670
gaagaggcuu ucagcauaaa                                                   20


<210>  19671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19671
ccugggacuc ugaagaggcu                                                   20


<210>  19672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19672
auuccuggag gcugagagau                                                   20


<210>  19673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19673
aggaauggag acagaaaccc                                                   20


<210>  19674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19674
gccuccagga auggagacag                                                   20


<210>  19675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19675
cagccuccag gaauggagac                                                   20


<210>  19676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19676
ucucucagcc uccaggaaug                                                   20


<210>  19677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19677
gcugcacccu caucucucag                                                   20


<210>  19678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19678
acuccagacc cugcagucug                                                   20


<210>  19679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19679
agacccugca gucugggcug                                                   20


<210>  19680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19680
gagcugccac agucagccuu                                                   20


<210>  19681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19681
gaggggcugc gguguggaag                                                   20


<210>  19682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19682
gugaacuaag gcugacugug                                                   20


<210>  19683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19683
gcuucccccu cggugaacua                                                   20


<210>  19684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19684
gggccucagc uucccccucg                                                   20


<210>  19685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19685
ugcucugggc cucagcuucc                                                   20


<210>  19686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19686
caugcucugg gccucagcuu                                                   20


<210>  19687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19687
gcuaaggacu auguggcccu                                                   20


<210>  19688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19688
aucuuugucc uuuuucuuua                                                   20


<210>  19689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19689
ccauagcaga ggcuuuucuu                                                   20


<210>  19690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19690
gcuaugggga gacugcgggu                                                   20


<210>  19691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19691
uuauauauua aggcuguugg                                                   20


<210>  19692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19692
ggcuucuuca gcccaacagc                                                   20


<210>  19693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19693
caggcuucuu cagcccaaca                                                   20


<210>  19694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19694
acagaaccag ccacccucuc                                                   20


<210>  19695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19695
uacacugaga auaggccuuu                                                   20


<210>  19696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19696
guguaggagg cccccaaacu                                                   20


<210>  19697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19697
uuucuccaaa gagugggcug                                                   20


<210>  19698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19698
aaagaguggg cuggcucaag                                                   20


<210>  19699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19699
uuggagaaac gagaaaaggc                                                   20


<210>  19700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19700
aguagggcag agagagaagc                                                   20


<210>  19701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19701
gcccuacuug agccagccca                                                   20


<210>  19702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19702
cugcccuacu ugagccagcc                                                   20


<210>  19703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19703
cucugcccua cuugagccag                                                   20


<210>  19704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19704
gccccaggcu ucucucucug                                                   20


<210>  19705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19705
cacgcucugu gcuggugucu                                                   20


<210>  19706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19706
gugcuggugu cuucacagcc                                                   20


<210>  19707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19707
ccaucuggcu gugccuguuu                                                   20


<210>  19708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19708
uucagaaucc agcuuauugu                                                   20


<210>  19709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19709
ugcuaccugc cagggugugg                                                   20


<210>  19710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19710
uacucuugcu accugccagg                                                   20


<210>  19711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19711
ccuacucuug cuaccugcca                                                   20


<210>  19712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19712
cuccuacucu ugcuaccugc                                                   20


<210>  19713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19713
ucucuccuac ucuugcuacc                                                   20


<210>  19714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19714
gagcacaggu uggguuugga                                                   20


<210>  19715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19715
gagugggugu cuccucucuc                                                   20


<210>  19716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19716
aaacccaacc ugugcucgga                                                   20


<210>  19717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19717
gucacucaaa ggcagagugg                                                   20


<210>  19718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19718
aaggcagagu ggggaguggg                                                   20


<210>  19719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19719
gccuuugagu gacagagugc                                                   20


<210>  19720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19720
ccacucugcc uuugagugac                                                   20


<210>  19721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19721
uaaggcccag ugcccacucc                                                   20


<210>  19722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19722
cuggacccag uaccuccuaa                                                   20


<210>  19723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19723
gccucacugg acccaguacc                                                   20


<210>  19724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19724
ggccaggcca gggaagaagc                                                   20


<210>  19725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19725
ugccuugacc ucccagaggg                                                   20


<210>  19726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19726
cagagggcag ccgaggccca                                                   20


<210>  19727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19727
gggaggucaa ggcaggagac                                                   20


<210>  19728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19728
gcugcccucu gggaggucaa                                                   20


<210>  19729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19729
ccugggccuc ggcugcccuc                                                   20


<210>  19730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19730
cagggcagga ccugucugca                                                   20


<210>  19731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19731
gggcaggacc ugucugcagg                                                   20


<210>  19732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19732
ugcagacagg uccugcccug                                                   20


<210>  19733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19733
uuaccacugg gacccccagc                                                   20


<210>  19734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19734
gggcagguug cagguuguag                                                   20


<210>  19735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19735
ugcccagacu guagguucaa                                                   20


<210>  19736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19736
caugccauuc uugguugaac                                                   20


<210>  19737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19737
cccagcuaca gggcagauuu                                                   20


<210>  19738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19738
auuuuuauau caaugacaua                                                   20


<210>  19739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19739
gagaggugaa ugaaccugcc                                                   20


<210>  19740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19740
gagccucuau uuuuauauca                                                   20


<210>  19741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19741
cugagccucu auuuuuauau                                                   20


<210>  19742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19742
acacuuugcu gugugacuuu                                                   20


<210>  19743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19743
ucuccacacu uugcugugug                                                   20


<210>  19744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19744
gggcugugga cacugaagcc                                                   20


<210>  19745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19745
aacgccagug gcugucgcuc                                                   20


<210>  19746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19746
cugaggcauu cucucccgaa                                                   20


<210>  19747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19747
gggagcgaca gccacuggcg                                                   20


<210>  19748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19748
cccgaacaac acaguuauua                                                   20


<210>  19749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19749
cgaacaacac aguuauuaua                                                   20


<210>  19750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19750
accuuucaaa augaauuauu                                                   20


<210>  19751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19751
uugcagagag ucuagaaacu                                                   20


<210>  19752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19752
gcaaugagca aauacugcuu                                                   20


<210>  19753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19753
cugcaaugag caaauacugc                                                   20


<210>  19754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19754
gauguuaaaa aggaagcaca                                                   20


<210>  19755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19755
agggucaaga ugacaaugga                                                   20


<210>  19756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19756
ccagcaaaau cggccaggcu                                                   20


<210>  19757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19757
gcuggcaagg gccuccccag                                                   20


<210>  19758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19758
cggcuggcaa gggccucccc                                                   20


<210>  19759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19759
ugccugugcc ggcguggcgc                                                   20


<210>  19760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19760
gcugaggcug ggcaggacag                                                   20


<210>  19761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19761
gcagaggggc gcgccacgcc                                                   20


<210>  19762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19762
guuucucacc cuuggcucuu                                                   20


<210>  19763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19763
cccuuggcuc uugugucucu                                                   20


<210>  19764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19764
ugugucucuc guuucaggaa                                                   20


<210>  19765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19765
cguuucagga aauuaaaaug                                                   20


<210>  19766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19766
uuucaggaaa uuaaaaugca                                                   20


<210>  19767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19767
cuaucuguca ugcauuuuaa                                                   20


<210>  19768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19768
gggaccuugg ccagaauccc                                                   20


<210>  19769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19769
acgucccaga ccgaggcguc                                                   20


<210>  19770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19770
gucugggacg uggagggccc                                                   20


<210>  19771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19771
guacuucccg uauaaccagu                                                   20


<210>  19772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19772
uacgaaggcc gcuucgagga                                                   20


<210>  19773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19773
aagcggccuu cguaggagca                                                   20


<210>  19774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19774
gacagcuccu ccagcuuacu                                                   20


<210>  19775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19775
uccagcuuac ugucccuuaa                                                   20


<210>  19776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19776
agcuuacugu cccuuaaguu                                                   20


<210>  19777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19777
gcccccacca uuuagagaaa                                                   20


<210>  19778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19778
aaaugguggg ggcugagaua                                                   20


<210>  19779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19779
cagucccuuu cucuaaaugg                                                   20


<210>  19780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19780
gcaaccacug uggccgccgc                                                   20


<210>  19781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19781
agggacaggc ggccucagac                                                   20


<210>  19782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19782
gaccagggag ggcuuuagug                                                   20


<210>  19783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19783
cuggucugag gccgccuguc                                                   20


<210>  19784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19784
gucugccugu ggacacuaaa                                                   20


<210>  19785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19785
cagcuccauc acuuuugagc                                                   20


<210>  19786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19786
aucacuuuug agcugcacgg                                                   20


<210>  19787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19787
aaagugaugg agcugggaga                                                   20


<210>  19788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19788
ggccucaguc ucccuccuau                                                   20


<210>  19789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19789
gucucccucc uauaaaaugg                                                   20


<210>  19790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19790
cuccuauaaa auggggguaa                                                   20


<210>  19791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19791
uauaaaaugg ggguaaauca                                                   20


<210>  19792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19792
gaggguggcu gggagcauca                                                   20


<210>  19793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19793
gagaaaggua cugauuuacc                                                   20


<210>  19794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19794
cagccacccu cugagaaagg                                                   20


<210>  19795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19795
ugugaugcuc ccagccaccc                                                   20


<210>  19796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19796
ccugugaugc ucccagccac                                                   20


<210>  19797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19797
gugugccggg ccccaugcug                                                   20


<210>  19798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19798
cuccgugugc cgggccccau                                                   20


<210>  19799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19799
cuuagcccac acagacccca                                                   20


<210>  19800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19800
caggcuagcu gcccucucag                                                   20


<210>  19801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19801
cagcacuggg gagggugucg                                                   20


<210>  19802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19802
gcacugggga gggugucggg                                                   20


<210>  19803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19803
ccagugcuga gagggcagcu                                                   20


<210>  19804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19804
ucacguguug ccgugggcau                                                   20


<210>  19805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19805
gccauccauc ccacaccuca                                                   20


<210>  19806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19806
gacccguccc gugcuggcca                                                   20


<210>  19807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19807
cagggcagcc gggagccagg                                                   20


<210>  19808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19808
cggcugcccu gugagcaucu                                                   20


<210>  19809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19809
ccaggcccac cccgcaggug                                                   20


<210>  19810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19810
gggcucccca ggcccacccc                                                   20


<210>  19811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19811
aaagcaccuu cucugggcuc                                                   20


<210>  19812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19812
ucaaaagcac cuucucuggg                                                   20


<210>  19813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19813
aaauggccaa cuucuauuuu                                                   20


<210>  19814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19814
aauccacaau cuuccuguuc                                                   20


<210>  19815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19815
ccugcccugg ucuucaaguc                                                   20


<210>  19816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19816
ugucagaaag acuugaagac                                                   20


<210>  19817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19817
acuaaagaua cuuuucugac                                                   20


<210>  19818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19818
gaggaggguc ccucucaugc                                                   20


<210>  19819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19819
gagacgccuu cucuacuaaa                                                   20


<210>  19820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19820
ucggagacgc cuucucuacu                                                   20


<210>  19821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19821
caugccgggg gccgcugcuu                                                   20


<210>  19822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19822
ugccgggggc cgcugcuuga                                                   20


<210>  19823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19823
ggauuucuca uugaagaccu                                                   20


<210>  19824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19824
uugaagaccu gagacaaaaa                                                   20


<210>  19825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19825
ggucuucaau gagaaauccu                                                   20


<210>  19826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19826
ugcugguucc uucuagcugc                                                   20


<210>  19827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19827
ggccuccugc ugguuccuuc                                                   20


<210>  19828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19828
guccacggga acaacagcca                                                   20


<210>  19829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19829
gacucagcug ccuggggccu                                                   20


<210>  19830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19830
gcugccuggg gccuugcaca                                                   20


<210>  19831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19831
cugaucaggc ccaaagcgcg                                                   20


<210>  19832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19832
cgccccugag guuggcugua                                                   20


<210>  19833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19833
ggggcgugag auccgcgcuu                                                   20


<210>  19834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19834
cagcucagag cagagugugg                                                   20


<210>  19835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19835
gcucagagca gagugugggc                                                   20


<210>  19836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19836
gagcagagug ugggccaggg                                                   20


<210>  19837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19837
gagcugagag gguacagcca                                                   20


<210>  19838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19838
gcucugagcu gagaggguac                                                   20


<210>  19839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19839
ucccuggccc acacucugcu                                                   20


<210>  19840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19840
agugccugcu caucccuggc                                                   20


<210>  19841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19841
cugcccuuca gggaggucug                                                   20


<210>  19842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19842
cugaagggca gggagcugcc                                                   20


<210>  19843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19843
gcagaccucc cugaagggca                                                   20


<210>  19844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19844
gcugcugggg uaggggccac                                                   20


<210>  19845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19845
caggaggcgc ccacagggcu                                                   20


<210>  19846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19846
ggaggcgccc acagggcugg                                                   20


<210>  19847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19847
ugagagcucu gcugcugggg                                                   20


<210>  19848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19848
ccaccucuac cagagcucug                                                   20


<210>  19849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19849
accagagcuc ugagguccug                                                   20


<210>  19850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19850
gguagaggug gugaguaaag                                                   20


<210>  19851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19851
gagguccugg ggagagagcc                                                   20


<210>  19852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19852
gagcucuggu agagguggug                                                   20


<210>  19853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19853
ccaggaccuc agagcucugg                                                   20


<210>  19854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19854
ccccaggacc ucagagcucu                                                   20


<210>  19855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19855
cuccccagga ccucagagcu                                                   20


<210>  19856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19856
ugugggcccc acacccucua                                                   20


<210>  19857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19857
aggugccugu ccuucugccu                                                   20


<210>  19858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19858
cuaccaaggu gugccggccc                                                   20


<210>  19859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19859
accaaggugu gccggcccca                                                   20


<210>  19860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19860
cggcggccua gaaauggggc                                                   20


<210>  19861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19861
caucucaggc ccuuccuucu                                                   20


<210>  19862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19862
ggcccuuccu ucugggaccu                                                   20


<210>  19863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19863
guuuccccau cugccuaagg                                                   20


<210>  19864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19864
ggaccccugu agggaagcca                                                   20


<210>  19865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19865
gcacuaccca gcacccccca                                                   20


<210>  19866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19866
cccugggggu ggucucucca                                                   20


<210>  19867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19867
cugggggugg ucucuccacc                                                   20


<210>  19868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19868
ccaccccugg cccccaacug                                                   20


<210>  19869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19869
accccuggcc cccaacuggg                                                   20


<210>  19870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19870
gccccaguug ggggccaggg                                                   20


<210>  19871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19871
cuggcaggau augccccucu                                                   20


<210>  19872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19872
gcagcccaga acaucccacc                                                   20


<210>  19873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19873
cuuucuuucu uuuucuuuuu                                                   20


<210>  19874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19874
uucuuucuuu uucuuuuuuu                                                   20


<210>  19875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19875
aaaaaaaaaa aaaagaaaaa                                                   20


<210>  19876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19876
gucucaaaaa aaaaaaaaaa                                                   20


<210>  19877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19877
cucuugugca gagagcagug                                                   20


<210>  19878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19878
ugugcagaga gcaguggcgc                                                   20


<210>  19879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19879
gcacaagagc gagacuccgu                                                   20


<210>  19880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19880
cugcacaaga gcgagacucc                                                   20


<210>  19881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19881
cugcaaccuc cgccucgugg                                                   20


<210>  19882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19882
gccucguggg uucaagcgau                                                   20


<210>  19883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19883
uggguucaag cgauucuccu                                                   20


<210>  19884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19884
ugccucagcc ucccgaguag                                                   20


<210>  19885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19885
gccucccgag uagcugggau                                                   20


<210>  19886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19886
cgaguagcug ggauuacagg                                                   20


<210>  19887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19887
ggaggcugag gcaggagaau                                                   20


<210>  19888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19888
acuaaaaaua caaaaauuag                                                   20


<210>  19889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19889
ugaccucagg ugauccaccu                                                   20


<210>  19890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19890
ggugauccac cugccucugc                                                   20


<210>  19891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19891
gccucccaaa gugcugggau                                                   20


<210>  19892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19892
caaagugcug ggauuacagg                                                   20


<210>  19893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19893
acacccggcc accccuguua                                                   20


<210>  19894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19894
uuugcacaug gaauaugaga                                                   20


<210>  19895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19895
uauuccaugu gcaaaggagg                                                   20


<210>  19896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19896
gggucucaua uuccaugugc                                                   20


<210>  19897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19897
cuggggccuc aguuucccca                                                   20


<210>  19898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19898
guuuccccau uugcccagua                                                   20


<210>  19899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19899
cgacaauccu acugggcaaa                                                   20


<210>  19900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19900
ccggacccuc ccgacaaucc                                                   20


<210>  19901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19901
guggccagca cguccacagc                                                   20


<210>  19902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19902
gaccuggaag gacagugccg                                                   20


<210>  19903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19903
uccgaccugg aaggacagug                                                   20


<210>  19904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19904
gcaccuugcg cuucuucacc                                                   20


<210>  19905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19905
agcagccgca gcugcuucuu                                                   20


<210>  19906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19906
accauggccu ccagcagccg                                                   20


<210>  19907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19907
uccaccaugg ccuccagcag                                                   20


<210>  19908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19908
gccggcgcug cuccuccacc                                                   20


<210>  19909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19909
acggcgcggc ucagccggcg                                                   20


<210>  19910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19910
uccacggcgc ggcucagccg                                                   20


<210>  19911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19911
cggcaggucu ccuccacggc                                                   20


<210>  19912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19912
gcaccugcag gaugugcugc                                                   20


<210>  19913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19913
ugcagcugca ggcucugcac                                                   20


<210>  19914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19914
ucaugcgcuc cugcagcugc                                                   20


<210>  19915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19915
agcagacuca ucaugcgcuc                                                   20


<210>  19916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19916
ccagcagacu caucaugcgc                                                   20


<210>  19917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19917
ggccacccag ggcaggccac                                                   20


<210>  19918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19918
ggccaggcgg gcaagggggc                                                   20


<210>  19919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19919
cggggcggcc cccuugcccg                                                   20


<210>  19920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19920
gcucgcgggg cggcccccuu                                                   20


<210>  19921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19921
ggcaggaugu cccuucugag                                                   20


<210>  19922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19922
gaagggacau ccugccagag                                                   20


<210>  19923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19923
aaauaccccu cagaagggac                                                   20


<210>  19924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19924
cgguccccag ggccuggggg                                                   20


<210>  19925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19925
agucuccagc augaaugccc                                                   20


<210>  19926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19926
agcaugaaug cccuuccucg                                                   20


<210>  19927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19927
gacacaggcc agggccucug                                                   20


<210>  19928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19928
gggguucacu ccgaguaaga                                                   20


<210>  19929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19929
gaguaagaac guccuagagc                                                   20


<210>  19930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19930
gagugaaccc cagaggcccu                                                   20


<210>  19931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19931
aggacguucu uacucggagu                                                   20


<210>  19932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19932
ccagugucgu uacuaucaau                                                   20


<210>  19933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19933
agugucguua cuaucaauga                                                   20


<210>  19934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19934
ccaagccagc aacagcaaac                                                   20


<210>  19935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19935
agccugcccc aacccguuuc                                                   20


<210>  19936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19936
cccagcucca gccugcccca                                                   20


<210>  19937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19937
cuccugaagg gaacccugug                                                   20


<210>  19938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19938
ccugaaggga acccuguguc                                                   20


<210>  19939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19939
ugaagggaac ccuguguccu                                                   20


<210>  19940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19940
cucaccagga ccucugcguc                                                   20


<210>  19941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19941
ccaggaccuc ugcgucucuc                                                   20


<210>  19942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19942
gcgucucucc uuaaauggcc                                                   20


<210>  19943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19943
ccuuaaaugg ccucugacgc                                                   20


<210>  19944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19944
uuaaauggcc ucugacgccu                                                   20


<210>  19945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19945
gacgccugau gaaaacccca                                                   20


<210>  19946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19946
uggaaggucg cugggguuuu                                                   20


<210>  19947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19947
guuuggagca ucagguguuu                                                   20


<210>  19948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19948
aaacagagcu gaauaaaagc                                                   20


<210>  19949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19949
uuagcaauga cacuaauaaa                                                   20


<210>  19950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19950
acagggcugu gcaugugaac                                                   20


<210>  19951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19951
agcacccaga acacucaaca                                                   20


<210>  19952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19952
uggagcuuau gcucccaugc                                                   20


<210>  19953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19953
aagaggccag ggccuuugug                                                   20


<210>  19954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19954
caugcgggga agacacaugg                                                   20


<210>  19955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19955
acugacccau gugucuuccc                                                   20


<210>  19956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19956
cuuccagcac uuaucacaac                                                   20


<210>  19957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19957
ggccaacccc ucccuuccag                                                   20


<210>  19958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19958
guguccucag gccaaccccu                                                   20


<210>  19959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19959
acguaugucu gccuccgugu                                                   20


<210>  19960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19960
gggccuucgc acuggccguu                                                   20


<210>  19961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19961
gccucugggc cuucgcacug                                                   20


<210>  19962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19962
aguguccucu gccucugggc                                                   20


<210>  19963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19963
ugggcuugcu ccaguguccu                                                   20


<210>  19964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19964
uagcugcucc ugggcuugcu                                                   20


<210>  19965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19965
ccacgggcug cacgggcuuc                                                   20


<210>  19966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19966
uccccacggg cugcacgggc                                                   20


<210>  19967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19967
cacuaagcuu gaaaagcaug                                                   20


<210>  19968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19968
gggucugaca ucgguggggg                                                   20


<210>  19969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19969
gucccccacc gaugucagac                                                   20


<210>  19970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19970
accaccccuc ugucccccac                                                   20


<210>  19971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19971
ccucacugcc ggcccuucca                                                   20


<210>  19972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19972
cugccggccc uuccaccagu                                                   20


<210>  19973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19973
uucuagaagc uccagcuuuc                                                   20


<210>  19974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19974
agcuuuccca aagcugaauu                                                   20


<210>  19975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19975
augagccucc uuggccggga                                                   20


<210>  19976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19976
uagagaauuc agcuuuggga                                                   20


<210>  19977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19977
uuggccggga cucgggcguc                                                   20


<210>  19978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19978
ggcgucuggu ugcccuggcu                                                   20


<210>  19979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19979
uuugcagcca gggcaaccag                                                   20


<210>  19980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19980
aacacaccug gccccagccu                                                   20


<210>  19981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19981
uggaauuagg caaguugcug                                                   20


<210>  19982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19982
ggguucagaa aaaucucccu                                                   20


<210>  19983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19983
cucuggcugc caagcgagca                                                   20


<210>  19984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19984
ggcugccaag cgagcaggcc                                                   20


<210>  19985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19985
cuuggcagcc agagggagau                                                   20


<210>  19986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19986
acggccugcu cgcuuggcag                                                   20


<210>  19987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19987
gcaccugucu ccacggccug                                                   20


<210>  19988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19988
uccuacccuc uagggggucu                                                   20


<210>  19989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19989
agggggucuu gaggucagcc                                                   20


<210>  19990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19990
agacccccua gaggguagga                                                   20


<210>  19991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19991
ugccuggcug accucaagac                                                   20


<210>  19992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19992
cuugccuggc ugaccucaag                                                   20


<210>  19993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19993
acugggugug ggaccagccu                                                   20


<210>  19994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19994
acaccaccau gguccacagg                                                   20


<210>  19995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19995
gccugccugu gugaaggaga                                                   20


<210>  19996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19996
uucacacagg caggccgagg                                                   20


<210>  19997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19997
ccuucacaca ggcaggccga                                                   20


<210>  19998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19998
acagaacacg ccggccucuc                                                   20


<210>  19999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  19999
ccuuugggcu ccacagaaca                                                   20


<210>  20000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20000
gaggguccug gagcucccac                                                   20


<210>  20001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20001
gagugaagug aauccugcuu                                                   20


<210>  20002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20002
aggacccuca gagugaagug                                                   20


<210>  20003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20003
cacccuccuc agccaucucc                                                   20


<210>  20004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20004
ucagccaucu ccccagagcc                                                   20


<210>  20005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20005
gccaucuccc cagagccugu                                                   20


<210>  20006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20006
ccagagccug ugugccgagg                                                   20


<210>  20007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20007
ggggagaugg cugaggaggg                                                   20


<210>  20008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20008
gcacacaggc ucuggggaga                                                   20


<210>  20009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20009
gcccauguug cugugggaug                                                   20


<210>  20010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20010
ucccacagca acaugggccg                                                   20


<210>  20011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20011
caucccacag caacaugggc                                                   20


<210>  20012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20012
gccucucauc ccacagcaac                                                   20


<210>  20013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20013
cgacacucug ccucucaucc                                                   20


<210>  20014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20014
uuacacccuc acgacacucu                                                   20


<210>  20015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20015
caccacugcc gccgcuccuu                                                   20


<210>  20016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20016
ucccaccacu gccgccgcuc                                                   20


<210>  20017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20017
cuccucccac cacugccgcc                                                   20


<210>  20018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20018
accacagggu cagcggcguc                                                   20


<210>  20019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20019
ucucaaccac agggucagcg                                                   20


<210>  20020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20020
gugcaucucu ucucaaccac                                                   20


<210>  20021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20021
ugcaagccag uguggcugcc                                                   20


<210>  20022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20022
gcaggugcua uggcagccac                                                   20


<210>  20023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20023
uggggccacc cuuccuucug                                                   20


<210>  20024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20024
guccuccugg ggccacccuu                                                   20


<210>  20025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20025
ggcccgcauc agaugugccc                                                   20


<210>  20026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20026
caaaacucag gcccgcauca                                                   20


<210>  20027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20027
agccaguuuc cagcuccggg                                                   20


<210>  20028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20028
gggacccacc cgccucguag                                                   20


<210>  20029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20029
uaggcaagac accacccaag                                                   20


<210>  20030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20030
aacuggacac cugugccacc                                                   20


<210>  20031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20031
guggucagca gcugggggca                                                   20


<210>  20032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20032
cauggggcca gugugggguu                                                   20


<210>  20033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20033
uaacagggag ccagucacaa                                                   20


<210>  20034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20034
cuguuaggag gcuggggaac                                                   20


<210>  20035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20035
agagggaagg gugcccgcgg                                                   20


<210>  20036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20036
agggcuugug acuggcuccc                                                   20


<210>  20037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20037
cgagggcuug ugacuggcuc                                                   20


<210>  20038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20038
cacaagacau aacagaugga                                                   20


<210>  20039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20039
aucuguuaug ucuuguggga                                                   20


<210>  20040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20040
acagcaguuu cagggugaag                                                   20


<210>  20041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20041
cggugugcug ucccggaugc                                                   20


<210>  20042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20042
cccucucuaa ucagagucag                                                   20


<210>  20043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20043
cuaaucagag ucagugauuc                                                   20


<210>  20044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20044
aaucagaguc agugauucau                                                   20


<210>  20045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20045
gauuagagag ggcgagaaga                                                   20


<210>  20046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20046
aaggugaugg aagggcauga                                                   20


<210>  20047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20047
aggcuggagc agcaucgccu                                                   20


<210>  20048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20048
agccuggaga aggucgggca                                                   20


<210>  20049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20049
ugucagcaga acucagcugu                                                   20


<210>  20050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20050
gcuguagaau aucguggggu                                                   20


<210>  20051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20051
uuaauggacc aacaacuaag                                                   20


<210>  20052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20052
gccauugcua aaauauuuga                                                   20


<210>  20053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20053
ugauucuagu uuucaauguu                                                   20


<210>  20054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20054
caaagugcug ggauuacagg                                                   20


<210>  20055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20055
gccucccaaa gugcugggau                                                   20


<210>  20056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20056
cgccucagcc ucccaaagug                                                   20


<210>  20057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20057
gaggucagga guucaagacc                                                   20


<210>  20058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20058
gaggauccuc ccgccucagc                                                   20


<210>  20059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20059
ugaccucaga ggauccuccc                                                   20


<210>  20060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20060
auguugguca ggcuggucuu                                                   20


<210>  20061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20061
ucauuacuaa aaauacaaaa                                                   20


<210>  20062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20062
caaguagcug ggauuacagg                                                   20


<210>  20063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20063
gccucccaag uagcugggau                                                   20


<210>  20064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20064
ugccucagcc ucccaaguag                                                   20


<210>  20065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20065
cggguucaag cgauucuccu                                                   20


<210>  20066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20066
gccucccggg uucaagcgau                                                   20


<210>  20067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20067
cugcaaccuc cgccucccgg                                                   20


<210>  20068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20068
gcucacugca accuccgccu                                                   20


<210>  20069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20069
agccugggug acagugaaac                                                   20


<210>  20070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20070
gucucaaaaa aaaaaaaaaa                                                   20


<210>  20071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20071
aaaaaaaaaa aaaauuaaaa                                                   20


<210>  20072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20072
acuuucuuca uuucuuaucc                                                   20


<210>  20073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20073
cagucuuuug uacauuuggc                                                   20


<210>  20074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20074
uuaaaccagc uuaaacuugu                                                   20


<210>  20075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20075
uuuucaacaa guuuaagcug                                                   20


<210>  20076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20076
gaaugggaua uuucuucauc                                                   20


<210>  20077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20077
acugaagaga acuaugcagu                                                   20


<210>  20078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20078
ucaguagagg uccuguuccu                                                   20


<210>  20079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20079
gguauuauuu agauuuuuca                                                   20


<210>  20080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20080
agcgcucagg uauuauuuag                                                   20


<210>  20081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20081
ugaaagcucc aaagucaaug                                                   20


<210>  20082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20082
aaagucaaug ucaucauuuu                                                   20


<210>  20083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20083
auaauaucac uucuugguuu                                                   20


<210>  20084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20084
cgcugacugg ccuuggacuu                                                   20


<210>  20085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20085
gccucccucg gagucgggga                                                   20


<210>  20086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20086
cucggagucg gggaguugga                                                   20


<210>  20087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20087
gagucgggga guuggaaccg                                                   20


<210>  20088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20088
gagggaggcc gagcggucuu                                                   20


<210>  20089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20089
ccgacuccga gggaggccga                                                   20


<210>  20090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20090
gucugcgguu ccaacucccc                                                   20


<210>  20091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20091
agcagccaca ugaucucagu                                                   20


<210>  20092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20092
auuucccgac guucguccug                                                   20


<210>  20093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20093
ugcguugcug gugggaugug                                                   20


<210>  20094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20094
uggaagcggc ugcaccacau                                                   20


<210>  20095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20095
ggucagugcc acuccuagac                                                   20


<210>  20096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20096
uagacaggcc acccugcggc                                                   20


<210>  20097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20097
aacuggucug aggaccccuc                                                   20


<210>  20098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20098
gaccaguuug aggacggcug                                                   20


<210>  20099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20099
acgcucuuaa aaaucauuaa                                                   20


<210>  20100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20100
uaaaaaucau uaaaaguggg                                                   20


<210>  20101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20101
caccuguaau cccagcacuu                                                   20


<210>  20102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20102
caaagugcug ggauuacagg                                                   20


<210>  20103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20103
ugauccgccu gucuuggccu                                                   20


<210>  20104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20104
auguccugac cucgugaucc                                                   20


<210>  20105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20105
acuaaaaaua caaaaaauua                                                   20


<210>  20106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20106
caaguagcug ggacuacagg                                                   20


<210>  20107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20107
gccucccaag uagcugggac                                                   20


<210>  20108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20108
uggcucagcc ucccaaguag                                                   20


<210>  20109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20109
uggguucacg ccauucuccu                                                   20


<210>  20110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20110
accuccuggg uucacgccau                                                   20


<210>  20111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20111
cugcaagcuc caccuccugg                                                   20


<210>  20112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20112
gcucacugca agcuccaccu                                                   20


<210>  20113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20113
acugcacucc agccugggca                                                   20


<210>  20114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20114
agccugggca gcagagcgag                                                   20


<210>  20115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20115
gcugcccagg cuggagugca                                                   20


<210>  20116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20116
cucugcugcc caggcuggag                                                   20


<210>  20117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20117
gucucaaaaa aaaauaauaa                                                   20


<210>  20118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20118
aaaaaaaaua auaaauaaau                                                   20


<210>  20119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20119
cauaagcaaa aguucuuugg                                                   20


<210>  20120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20120
gguuuaauuu cuaauaagau                                                   20


<210>  20121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20121
cgaaaacuuu uuguuuugga                                                   20


<210>  20122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20122
ggcuuaagag aagcccacug                                                   20


<210>  20123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20123
uaagccagag auuuacgacc                                                   20


<210>  20124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20124
cagcaggcuc uggguccguc                                                   20


<210>  20125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20125
gcaggcucug gguccgucca                                                   20


<210>  20126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20126
ggguccgucc acuuuggggg                                                   20


<210>  20127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20127
uauacuucac aaccaaaaca                                                   20


<210>  20128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20128
auucacuccu auacuucaca                                                   20


<210>  20129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20129
uucuuaccca gauguguauu                                                   20


<210>  20130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20130
aaaaaaaaaa aacaaaccac                                                   20


<210>  20131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20131
gucuccaaaa aaaaaaaaca                                                   20


<210>  20132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20132
gucacucagg cuggagugca                                                   20


<210>  20133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20133
ggcuggagug caguggcgcg                                                   20


<210>  20134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20134
agccugagug acagagcggg                                                   20


<210>  20135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20135
cugcaagcuc cgccuccugg                                                   20


<210>  20136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20136
gccuccuggg uucacugcaa                                                   20


<210>  20137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20137
uggguucacu gcaagcucug                                                   20


<210>  20138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20138
gccucccggg uucacgccau                                                   20


<210>  20139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20139
cggguucacg ccauucuccu                                                   20


<210>  20140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20140
ugccucagcc uccugaguag                                                   20


<210>  20141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20141
gccuccugag uagcugggac                                                   20


<210>  20142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20142
ugaguagcug ggacuacagg                                                   20


<210>  20143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20143
ggaggcugag gcaggagaau                                                   20


<210>  20144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20144
acuaaaaaua caaaaaauua                                                   20


<210>  20145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20145
aucuccugac aucgugaucc                                                   20


<210>  20146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20146
ugacaucgug auccacccgc                                                   20


<210>  20147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20147
gccucccaaa gugcuggaau                                                   20


<210>  20148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20148
caaagugcug gaauuacagg                                                   20


<210>  20149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20149
ugaaaugaag uagaaguuca                                                   20


<210>  20150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20150
guccaucaug ccuuugugac                                                   20


<210>  20151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20151
cacgcugggc cuuugguuca                                                   20


<210>  20152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20152
uggugguguc uuucagaauu                                                   20


<210>  20153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20153
uucaaagaaa auagcugaca                                                   20


<210>  20154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20154
cuuuguucgu uuuccaaaaa                                                   20


<210>  20155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20155
gguuguucag ccuugggugu                                                   20


<210>  20156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20156
aaaaaaggau gugcaaaaac                                                   20


<210>  20157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20157
auacgugugu uccagaucca                                                   20


<210>  20158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20158
gcccauugca caccugcauu                                                   20


<210>  20159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20159
gcguggacgu ggggcaggcg                                                   20


<210>  20160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20160
ggcaggacgu ugaaaagaug                                                   20


<210>  20161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20161
cacacucgac cauuuucacu                                                   20


<210>  20162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20162
accauuuuca cuccaucacg                                                   20


<210>  20163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20163
aucacggaca uuuggaagug                                                   20


<210>  20164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20164
gggcugcgcc ggggcucggg                                                   20


<210>  20165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20165
gggccugccu gcguuccugc                                                   20


<210>  20166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20166
ggucuugcca caucagugcg                                                   20


<210>  20167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20167
gugaagaccc cgugaagacc                                                   20


<210>  20168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20168
gggacccuug gugacccaca                                                   20


<210>  20169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20169
gccugugggu caccaagggu                                                   20


<210>  20170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20170
ggucucggcc ugugggucac                                                   20


<210>  20171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20171
agcauucagg cagugguucu                                                   20


<210>  20172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20172
ggucaccugu gugcccgcuc                                                   20


<210>  20173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20173
cucaggucac cugugugccc                                                   20


<210>  20174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20174
ucuguccuug cccgguaccc                                                   20


<210>  20175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20175
ggguaccggg caaggacaga                                                   20


<210>  20176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20176
cuggcgauug guggacgcac                                                   20


<210>  20177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20177
gugugacugg guggcgucau                                                   20


<210>  20178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20178
gggcccgcuu gggggcacgg                                                   20


<210>  20179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20179
cugcugucuu guaggcacug                                                   20


<210>  20180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20180
aaacccugua aagacaaaga                                                   20


<210>  20181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20181
acucgaaacc cuguaaagac                                                   20


<210>  20182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20182
ucuaacauac uagacacuua                                                   20


<210>  20183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20183
cuucuaacau acuagacacu                                                   20


<210>  20184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20184
aaucccccua cagccuuauu                                                   20


<210>  20185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20185
ccccacggcu ccaauccccc                                                   20


<210>  20186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20186
caccccacgg cuccaauccc                                                   20


<210>  20187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20187
caugacauuu uuugaaggcc                                                   20


<210>  20188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20188
auccgcucac augacauuuu                                                   20


<210>  20189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20189
cacuccaucc gcucacauga                                                   20


<210>  20190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20190
ccugagcacu gggagcugca                                                   20


<210>  20191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20191
ggugagggcg ccccucccac                                                   20


<210>  20192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20192
cagugcucag gugagggcgc                                                   20


<210>  20193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20193
caccuagaca gugcagcucc                                                   20


<210>  20194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20194
gagggcgagg ugggccugga                                                   20


<210>  20195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20195
gagccagcuc ccaccuagac                                                   20


<210>  20196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20196
cccucagagc cagcucccac                                                   20


<210>  20197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20197
ugucccagca gaaagcaggg                                                   20


<210>  20198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20198
cuugucccag cagaaagcag                                                   20


<210>  20199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20199
gggacucucu ugucccagca                                                   20


<210>  20200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20200
cugcuccggg acucucuugu                                                   20


<210>  20201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20201
acgccacacc ugacccuccc                                                   20


<210>  20202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20202
caggcuccac gccacaccug                                                   20


<210>  20203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20203
cccaccuccc aggcuccacg                                                   20


<210>  20204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20204
ggaggcaucc uggccuaggg                                                   20


<210>  20205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20205
ugagcacccc ucacccaccu                                                   20


<210>  20206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20206
ccuaggccag gaugccuccu                                                   20


<210>  20207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20207
gugugcuggc uuugcgcucg                                                   20


<210>  20208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20208
uggccaucuc caggacucag                                                   20


<210>  20209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20209
aggacucaga acaugcgaga                                                   20


<210>  20210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20210
gaacaugcga gaggcacgca                                                   20


<210>  20211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20211
cauguucuga guccuggaga                                                   20


<210>  20212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20212
cgcauguucu gaguccugga                                                   20


<210>  20213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20213
accuugcgug ccucucgcau                                                   20


<210>  20214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20214
cacacgcucc accuugcgug                                                   20


<210>  20215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20215
gcuggguccg gagggagagg                                                   20


<210>  20216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20216
ggacccagcu gagaugaacu                                                   20


<210>  20217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20217
cuccggaccc agcugagaug                                                   20


<210>  20218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20218
cccuccggac ccagcugaga                                                   20


<210>  20219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20219
uguucuaggg guagggugcc                                                   20


<210>  20220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20220
cagauguguc aguucuuggc                                                   20


<210>  20221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20221
ccucagcuca gggaaguggg                                                   20


<210>  20222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20222
gcucagggaa gugggacccc                                                   20


<210>  20223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20223
gggaaguggg accccugcac                                                   20


<210>  20224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20224
guuuaucucc gccuugcugg                                                   20


<210>  20225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20225
gccuugcugg gcacuagcuc                                                   20


<210>  20226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20226
gcuucacugc uuuccgucaa                                                   20


<210>  20227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20227
ccugcucugc accaccaugu                                                   20


<210>  20228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20228
ugcucugcac caccaugucc                                                   20


<210>  20229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20229
gcaccaccau guccagaccu                                                   20


<210>  20230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20230
aggucuggac augguggugc                                                   20


<210>  20231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20231
ucccccacaa augucauauu                                                   20


<210>  20232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20232
aggggguaaa uaugacauuu                                                   20


<210>  20233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20233
agguccucua ggggguaaau                                                   20


<210>  20234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20234
uguccucuag guccucuagg                                                   20


<210>  20235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20235
cuccuguccu cuagguccuc                                                   20


<210>  20236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20236
ggucugcccu ccccguuggg                                                   20


<210>  20237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20237
ccguuggggc caagugcccg                                                   20


<210>  20238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20238
cuaagaaagg cugugacguu                                                   20


<210>  20239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20239
agccccaaag gcguucccca                                                   20


<210>  20240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20240
uuuggauguu uucccugauc                                                   20


<210>  20241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20241
gcuguagccu gugggcuacc                                                   20


<210>  20242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20242
cccugggcac acccucagcu                                                   20


<210>  20243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20243
cgcccugggc acacccucag                                                   20


<210>  20244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20244
gcggggcucu gggcugcccu                                                   20


<210>  20245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20245
gggcugcccu ugcggcguga                                                   20


<210>  20246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20246
cgccgcaagg gcagcccaga                                                   20


<210>  20247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20247
ugcugccggg cgugcugggc                                                   20


<210>  20248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20248
gcccagcacg cccggcagca                                                   20


<210>  20249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20249
uccuaggagg ucacggagga                                                   20


<210>  20250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20250
uaggaagagc uguccaagac                                                   20


<210>  20251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20251
gugaccuccu aggaagagcu                                                   20


<210>  20252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20252
uuuggaaacg guuuuuaggg                                                   20


<210>  20253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20253
cagccugagu ccgaucucac                                                   20


<210>  20254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20254
gccugagucc gaucucacag                                                   20


<210>  20255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20255
ggcugagagg ugcacacccu                                                   20


<210>  20256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20256
cagagacugu gugagcugcu                                                   20


<210>  20257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20257
gugagaucgg acucaggcug                                                   20


<210>  20258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20258
cacagucucu gugagaucgg                                                   20


<210>  20259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20259
cccucgugac ccccuucagc                                                   20


<210>  20260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20260
ugacccccuu cagcucaugc                                                   20


<210>  20261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20261
ugccagccug ccugaucugc                                                   20


<210>  20262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20262
cacaaguacc ugcugcucug                                                   20


<210>  20263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20263
gaaccuugcc auuuucggca                                                   20


<210>  20264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20264
uccucuugaa cgggagaauc                                                   20


<210>  20265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20265
ucuugaacgg gagaaucgga                                                   20


<210>  20266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20266
ugaacgggag aaucggauuc                                                   20


<210>  20267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20267
cguucaagag gaggagggca                                                   20


<210>  20268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20268
acacacugga auccgauucu                                                   20


<210>  20269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20269
ugggucccuu acugauggag                                                   20


<210>  20270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20270
aucaguaagg gacccacgag                                                   20


<210>  20271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20271
ccaucaguaa gggacccacg                                                   20


<210>  20272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20272
gcaauaaacc guggugcagc                                                   20


<210>  20273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20273
cuguguacuu guguacacua                                                   20


<210>  20274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20274
guguacuugu guacacuagu                                                   20


<210>  20275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20275
cuaguguaca caaguacaca                                                   20


<210>  20276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20276
uccuucaaaa cucacuagug                                                   20


<210>  20277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20277
aggggaaacg aaaaguugua                                                   20


<210>  20278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20278
cguguaagcc auuuguagcc                                                   20


<210>  20279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20279
acccgaccuc acguguaagc                                                   20


<210>  20280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20280
ucuacaaacg gugcuguaac                                                   20


<210>  20281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20281
auagcgacag gacacccucu                                                   20


<210>  20282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20282
uucuugaaga uggauggccu                                                   20


<210>  20283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20283
uuuuuaggau cugaaauuau                                                   20


<210>  20284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20284
agaauguagc gucagaaauu                                                   20


<210>  20285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20285
agaagcacac agguggggau                                                   20


<210>  20286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20286
gaccccaucu gucugcucua                                                   20


<210>  20287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20287
ccucugaccc caucugucug                                                   20


<210>  20288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20288
caaauccccg cugccucacc                                                   20


<210>  20289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20289
ugccucccaa auccccgcug                                                   20


<210>  20290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20290
gccaaccaug gcccugaccu                                                   20


<210>  20291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20291
ugaccaucag uggccucugc                                                   20


<210>  20292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20292
uccugcugug ugcagccucc                                                   20


<210>  20293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20293
ugcugugugc agccuccuuc                                                   20


<210>  20294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20294
uuccugccgg gcccugcuga                                                   20


<210>  20295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20295
ggccgcccug aggugcacag                                                   20


<210>  20296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20296
gggcggccug aggucagggc                                                   20


<210>  20297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20297
gugcaccuca gggcggccug                                                   20


<210>  20298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20298
uagauaagau ugcuggaucc                                                   20


<210>  20299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20299
ugggacccug caggcuccua                                                   20


<210>  20300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20300
cuugucucau gggacccugc                                                   20


<210>  20301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20301
ucuguuugcg caagaagcaa                                                   20


<210>  20302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20302
accucgucug uuugcgcaag                                                   20


<210>  20303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20303
uccaccucgu cuguuugcgc                                                   20


<210>  20304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20304
ccaucggccu ucuagggccc                                                   20


<210>  20305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20305
aucggccuuc uagggcccug                                                   20


<210>  20306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20306
gggcccuaga aggccgaugg                                                   20


<210>  20307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20307
ggacugccuc agggcccuag                                                   20


<210>  20308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20308
cccucaggac ugccucaggg                                                   20


<210>  20309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20309
ggugggcgug gcccucaccc                                                   20


<210>  20310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20310
gcucuggugg gcguggcccu                                                   20


<210>  20311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20311
ggccccuccg cucugguggg                                                   20


<210>  20312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20312
cacagaagca gccaggccca                                                   20


<210>  20313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20313
aaaauugcau uuggcuucaa                                                   20


<210>  20314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20314
caaaaauugc auuuggcuuc                                                   20


<210>  20315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20315
ccuuuugggc acuaaauucc                                                   20


<210>  20316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20316
cuccccuuuu gggcacuaaa                                                   20


<210>  20317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20317
uacagcaugg cauuggcucg                                                   20


<210>  20318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20318
ugaggcugcu gaauggggcg                                                   20


<210>  20319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20319
cgagccaaug ccaugcugua                                                   20


<210>  20320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20320
ccacgcccca uucagcagcc                                                   20


<210>  20321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20321
uccccacgcc ccauucagca                                                   20


<210>  20322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20322
ugggccagca gaccacccac                                                   20


<210>  20323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20323
cggccugugg guggucugcu                                                   20


<210>  20324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20324
ggcugcccuc ccggccugug                                                   20


<210>  20325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20325
ucaggcugcc cucccggccu                                                   20


<210>  20326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20326
uucuugggga acuuugcuga                                                   20


<210>  20327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20327
ugccaccccg cccgcuggcu                                                   20


<210>  20328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20328
cuagcccagc ugcagcuccu                                                   20


<210>  20329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20329
cugcccgugg ggugcuauga                                                   20


<210>  20330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20330
gcccgugggg ugcuaugaaa                                                   20


<210>  20331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20331
aaaucacacc ggcuuucaua                                                   20


<210>  20332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20332
gcagggcugu ccccaggcug                                                   20


<210>  20333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20333
ugcaaugucg gcagccuggg                                                   20


<210>  20334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20334
acggggcccc agaucugggg                                                   20


<210>  20335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20335
gcggacacag agucaaaucu                                                   20


<210>  20336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20336
guguccgcag aguccgguga                                                   20


<210>  20337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20337
cccacaggcc caguguaccc                                                   20


<210>  20338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20338
aggaggggaa gaugggggcg                                                   20


<210>  20339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20339
uugagggcca acccacagcc                                                   20


<210>  20340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20340
acaacgccac cccugccugc                                                   20


<210>  20341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20341
uggaccucca caacgccacc                                                   20


<210>  20342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20342
ucauggaccu ccacaacgcc                                                   20


<210>  20343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20343
caggcugccc ugcccuccuc                                                   20


<210>  20344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20344
cccgugcugc caggaucuac                                                   20


<210>  20345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20345
gggcccuucc cuuacucacc                                                   20


<210>  20346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20346
ucagggcccu ucccuuacuc                                                   20


<210>  20347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20347
ccuccucagg gcccuucccu                                                   20


<210>  20348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20348
ggucuugcuc agcccuagac                                                   20


<210>  20349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20349
gcccuagacu ggcucugacc                                                   20


<210>  20350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20350
gaccccacac ccaggguugc                                                   20


<210>  20351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20351
ccccaccacg uugcaacccu                                                   20


<210>  20352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20352
uggguggccc ugcugcugug                                                   20


<210>  20353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20353
aagucaggag gaaggaggcc                                                   20


<210>  20354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20354
ugacuuggag acccugugca                                                   20


<210>  20355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20355
uuccuccuga cuuggagacc                                                   20


<210>  20356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20356
uggccuccuu ccuccugacu                                                   20


<210>  20357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20357
acuccuggcc uccuuccucc                                                   20


<210>  20358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20358
gcccugccac gcaggguugu                                                   20


<210>  20359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20359
guccuacugc ucggggucca                                                   20


<210>  20360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20360
ggguccaggu ucuggggcuc                                                   20


<210>  20361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20361
guccucugcg agcaccucuc                                                   20


<210>  20362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20362
gcgagcaccu cucagccucg                                                   20


<210>  20363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20363
cagaggacag agccccagaa                                                   20


<210>  20364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20364
cagccucgca ccccugggga                                                   20


<210>  20365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20365
gccucgcacc ccuggggagc                                                   20


<210>  20366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20366
caccccuggg gagcggcuuu                                                   20


<210>  20367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20367
ccaggggugc gaggcugaga                                                   20


<210>  20368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20368
caggugcgcc ugggaacccu                                                   20


<210>  20369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20369
ccugcgaaag gggagcgggg                                                   20


<210>  20370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20370
ccuuucgcag gugagaacag                                                   20


<210>  20371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20371
ccgcuccccu uucgcaggug                                                   20


<210>  20372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20372
ugcuccuccu ccugcaggca                                                   20


<210>  20373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20373
uccuccugca ggcaccgccc                                                   20


<210>  20374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20374
uccugcaggc accgccccuc                                                   20


<210>  20375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20375
ugcaggcacc gccccuccac                                                   20


<210>  20376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20376
accccacaga gggcuucugc                                                   20


<210>  20377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20377
guggggugga ggggcggugc                                                   20


<210>  20378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20378
ugacuuauuc ccuuguuuaa                                                   20


<210>  20379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20379
gcucagggcg gguggggucu                                                   20


<210>  20380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20380
gggcgggugg ggucuggagu                                                   20


<210>  20381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20381
agaccccacc cgcccugagc                                                   20


<210>  20382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20382
cccaacagcc caccugcucc                                                   20


<210>  20383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20383
ccgcccggcc gccuggcgca                                                   20


<210>  20384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20384
gcgccaggcg gccgggcggg                                                   20


<210>  20385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20385
aaacuagggc cucugcgcca                                                   20


<210>  20386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20386
ccaaacuagg gccucugcgc                                                   20


<210>  20387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20387
gaauuuggau ucaaccacgg                                                   20


<210>  20388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20388
cucauuuucc aaaacgccuu                                                   20


<210>  20389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20389
uuuuccaaaa cgccuuuguc                                                   20


<210>  20390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20390
ugaaaguucu uugaacagga                                                   20


<210>  20391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20391
ccagggugcc agcuggcauc                                                   20


<210>  20392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20392
gccuucgaaa cuaauggaau                                                   20


<210>  20393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20393
accgagcggc ugcagcaggg                                                   20


<210>  20394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20394
guggagcgcu gcuauucuua                                                   20


<210>  20395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20395
gggcccugcu gcagccgcuc                                                   20


<210>  20396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20396
augugggagc cgugcccagg                                                   20


<210>  20397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20397
cacauggagg cuggcgccca                                                   20


<210>  20398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20398
cugggcacgg cucccacaug                                                   20


<210>  20399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20399
cgcagcccac accaggugcc                                                   20


<210>  20400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20400
cuuacaggca gcugcugaag                                                   20


<210>  20401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20401
accugaccag gacgguccca                                                   20


<210>  20402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20402
uccaccugac caggacgguc                                                   20


<210>  20403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20403
ggguccaaag uccaggacac                                                   20


<210>  20404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20404
auacaaauuu cagcaggcuu                                                   20


<210>  20405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20405
augucuuuua uuucucuuuc                                                   20


<210>  20406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20406
uucuugccuu auuuucuggc                                                   20


<210>  20407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20407
uagccagaaa auaaggcaag                                                   20


<210>  20408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20408
aguacaaugu ugaaaagaag                                                   20


<210>  20409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20409
ugaacacaga cacaaaaucc                                                   20


<210>  20410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20410
ugauguccuu gucagguuuu                                                   20


<210>  20411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20411
gauaucaaaa ccugacaagg                                                   20


<210>  20412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20412
ugcacuuacu guaugaaacc                                                   20


<210>  20413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20413
uuuuucugaa aaaaauugug                                                   20


<210>  20414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20414
uauuuuuguc auucccuucc                                                   20


<210>  20415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20415
uuauuuucua gcuucuuaau                                                   20


<210>  20416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20416
gaucauuuau uucaaacuag                                                   20


<210>  20417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20417
ggucaaacaa gauaucacaa                                                   20


<210>  20418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20418
uuaaaugcua aaggacugaa                                                   20


<210>  20419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20419
ugaaaagagu auuuauucua                                                   20


<210>  20420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20420
uuucaagagc acaugguaca                                                   20


<210>  20421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20421
cgccuguaau cccagcacuu                                                   20


<210>  20422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20422
aauguuugaa aauauagcca                                                   20


<210>  20423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20423
aucuacuuug aaaucauauu                                                   20


<210>  20424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20424
uagaucccca aagcucaaua                                                   20


<210>  20425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20425
aacugaauuu aaaaaaauca                                                   20


<210>  20426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20426
ccauuuuacc uguacucuuu                                                   20


<210>  20427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20427
ccaauacaug uuuuauuuca                                                   20


<210>  20428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20428
ggaaacaauc acaaauagaa                                                   20


<210>  20429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20429
cacaugagca gagcagucac                                                   20


<210>  20430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20430
ugugugagaa gcucuggaaa                                                   20


<210>  20431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20431
gcucaugugu gagaagcucu                                                   20


<210>  20432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20432
ccuugacaau cuuuuaaaaa                                                   20


<210>  20433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20433
acagccuccc cuugacaauc                                                   20


<210>  20434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20434
ucccuuaccc auugugauag                                                   20


<210>  20435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20435
ggguauucca aagcacaucc                                                   20


<210>  20436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20436
auguguauca uauuugaccu                                                   20


<210>  20437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20437
gaaccacaaa agaaugucaa                                                   20


<210>  20438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20438
ucuaauacau cuugaauacu                                                   20


<210>  20439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20439
uguaaaauaa gcaauaaaaa                                                   20


<210>  20440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20440
auugaagaga gaugugaaua                                                   20


<210>  20441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20441
ucaauugaga uuauuccuua                                                   20


<210>  20442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20442
cuucaauuga gauuauuccu                                                   20


<210>  20443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20443
guuuauucac aucucucuuc                                                   20


<210>  20444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20444
gcacuggcaa auuugaaaga                                                   20


<210>  20445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20445
uaaagcaaca ccuagauuca                                                   20


<210>  20446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20446
caaagagcug ggauuacagg                                                   20


<210>  20447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20447
agugauccac ccaccugggc                                                   20


<210>  20448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20448
uacccucaag ugauccaccc                                                   20


<210>  20449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20449
guuucuacua aaaauacaaa                                                   20


<210>  20450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20450
guucaguuca cucuguuguu                                                   20


<210>  20451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20451
cccacgaugg gcagcagcua                                                   20


<210>  20452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20452
gucuccccca cgaugggcag                                                   20


<210>  20453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20453
aaucccaaac ucugucuccc                                                   20


<210>  20454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20454
uagaagaaaa ucaacacuuc                                                   20


<210>  20455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20455
gauaaagaua auagaaucca                                                   20


<210>  20456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20456
guucaugcug cugcaaucau                                                   20


<210>  20457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20457
gaccacuauu auuucugaug                                                   20


<210>  20458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20458
aaaaaauaau aauaaaacaa                                                   20


<210>  20459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20459
gcugguguau cccacuggcc                                                   20


<210>  20460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20460
caucucugcu gguguauccc                                                   20


<210>  20461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20461
ugcucccauc ucugcuggug                                                   20


<210>  20462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20462
cucuggaguc ugauagcccu                                                   20


<210>  20463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20463
cuggagucug auagcccuuc                                                   20


<210>  20464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20464
ggagucugau agcccuucgu                                                   20


<210>  20465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20465
agagagagca cagcccuccu                                                   20


<210>  20466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20466
agccaacaac ccaauuccca                                                   20


<210>  20467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20467
ugccgccccu ggggcucaag                                                   20


<210>  20468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20468
cccuggccaa ugggaagcgc                                                   20


<210>  20469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20469
agggcauccu gcuggcgcuu                                                   20


<210>  20470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20470
ccuccagggc auccugcugg                                                   20


<210>  20471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20471
gcugcucccu aaacuacccc                                                   20


<210>  20472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20472
cuaaacuacc ccaccgcccc                                                   20


<210>  20473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20473
cugaaugcuu uuuuuuuuuu                                                   20


<210>  20474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20474
acacucagga ggcugaggua                                                   20


<210>  20475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20475
ggaggcugag guaggaggau                                                   20


<210>  20476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20476
ugaguguuga gauuacaggc                                                   20


<210>  20477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20477
gccuccugag uguugagauu                                                   20


<210>  20478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20478
uaccucagcc uccugagugu                                                   20


<210>  20479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20479
agccauccuc cuaccucagc                                                   20


<210>  20480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20480
acuucccaga cucaagccau                                                   20


<210>  20481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20481
cugcagccuc aacuucccag                                                   20


<210>  20482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20482
agccugggca acagggcaag                                                   20


<210>  20483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20483
aaaaaaaaaa aaaaaaaaaa                                                   20


<210>  20484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20484
ggccgccagg gccaggggcu                                                   20


<210>  20485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20485
uggcaauuag ggacguuguc                                                   20


<210>  20486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20486
acuuaguaac aauaugcucu                                                   20


<210>  20487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20487
auuuaauuaa cuuuguguau                                                   20


<210>  20488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20488
cugaugguga auuccacaac                                                   20


<210>  20489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20489
accaaaaaca caaaaaauua                                                   20


<210>  20490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20490
aacuccugag cuuaagugag                                                   20


<210>  20491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20491
ugagcuuaag ugagccaccu                                                   20


<210>  20492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20492
ggaguuggag accagccugg                                                   20


<210>  20493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20493
cuuaagcuca ggaguuggag                                                   20


<210>  20494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20494
gccuuccaaa gagcugggau                                                   20


<210>  20495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20495
uuggaaggcu gagguaggug                                                   20


<210>  20496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20496
agggcaggga caaguggccc                                                   20


<210>  20497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20497
ggaggcugag cucugcggcc                                                   20


<210>  20498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20498
ugaggcucca gggcagggac                                                   20


<210>  20499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20499
gccuccugag gcuccagggc                                                   20


<210>  20500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20500
gcggccugcu uccuucuggc                                                   20


<210>  20501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20501
ggaagauucc accaucugcg                                                   20


<210>  20502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20502
aaaaaaaaaa aaaaagagcc                                                   20


<210>  20503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20503
aucucaaaaa aaaaaaaaaa                                                   20


<210>  20504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20504
gucaccuagg cuggagugca                                                   20


<210>  20505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20505
agccuaggug acagagugaa                                                   20


<210>  20506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20506
gcucacagca accuccgccu                                                   20


<210>  20507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20507
cagcaaccuc cgccuccggg                                                   20


<210>  20508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20508
gccuccgggg cucaagugau                                                   20


<210>  20509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20509
ggggcucaag ugauucuccu                                                   20


<210>  20510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20510
cgccgcguuu uucccucgag                                                   20


<210>  20511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20511
cccgccgcgu uuuucccucg                                                   20


<210>  20512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20512
uucucucccg ccgcguuuuu                                                   20


<210>  20513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20513
cugccccuuc cuuccugccu                                                   20


<210>  20514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20514
ccguccccgc cccuccuccg                                                   20


<210>  20515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20515
guccccgccc cuccuccggc                                                   20


<210>  20516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20516
uccggccucg gccccgcccu                                                   20


<210>  20517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20517
ggccucggcc ccgcccucgc                                                   20


<210>  20518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20518
gccccgcccu cgccucgacc                                                   20


<210>  20519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20519
ccucgacccc ggggggcggu                                                   20


<210>  20520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20520
accccggggg gcgguggcug                                                   20


<210>  20521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20521
gcagccaccg ccccccgggg                                                   20


<210>  20522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20522
gggcgcuucg gcccgcgcca                                                   20


<210>  20523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20523
cgcuccgggc gcuucggccc                                                   20


<210>  20524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20524
cucccgcucc gggcgcuucg                                                   20


<210>  20525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20525
cagcgcuccc gggcgcaucu                                                   20


<210>  20526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20526
ucggacucca cgagcggccg                                                   20


<210>  20527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20527
acgagcggcc gcuuuguuag                                                   20


<210>  20528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20528
uggaguccga cgagggaacc                                                   20


<210>  20529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20529
gaaggcagcu ucugcccuaa                                                   20


<210>  20530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20530
agacgcacug cagcgaccug                                                   20


<210>  20531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20531
acggcucugg gcccccucuc                                                   20


<210>  20532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20532
gucuacacuc cacggcucug                                                   20


<210>  20533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20533
cugucuacac uccacggcuc                                                   20


<210>  20534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20534
cucugucuac acuccacggc                                                   20


<210>  20535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20535
gggcccucuc ucugucuaca                                                   20


<210>  20536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20536
gucuacacua gauggcucug                                                   20


<210>  20537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20537
cugucuacac uagauggcuc                                                   20


<210>  20538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20538
acagcuaugg guccccucuc                                                   20


<210>  20539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20539
gugccugagu uuccucauug                                                   20


<210>  20540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20540
ggcacagaga agguggucac                                                   20


<210>  20541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20541
uuggaccugu cuuuggagcu                                                   20


<210>  20542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20542
aguccccaaa agcacuggcc                                                   20


<210>  20543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20543
ggcaagggca gugggguggc                                                   20


<210>  20544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20544
gccaccccac ugcccuugcc                                                   20


<210>  20545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20545
gugacuggca gagcagaggg                                                   20


<210>  20546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20546
gccagucaca gaggcauccg                                                   20


<210>  20547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20547
gcucugccag ucacagaggc                                                   20


<210>  20548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20548
cucugcucug ccagucacag                                                   20


<210>  20549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20549
ucccucugcu cugccaguca                                                   20


<210>  20550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20550
ggucaccacu gcccugucgc                                                   20


<210>  20551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20551
gggagguuga caaagacaag                                                   20


<210>  20552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20552
cugagaccuc cggucaccac                                                   20


<210>  20553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20553
gcccuugucu uugucaaccu                                                   20


<210>  20554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20554
cguggacugg agguacagua                                                   20


<210>  20555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20555
uugcagugcc ugucgagugc                                                   20


<210>  20556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20556
ucuuugcagu gccugucgag                                                   20


<210>  20557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20557
cuuucugccc uguuuaggau                                                   20


<210>  20558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20558
uccuaaacag ggcagaaagg                                                   20


<210>  20559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20559
gggaagaagg gguggccagg                                                   20


<210>  20560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20560
uacaacuggg aagggaaaug                                                   20


<210>  20561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20561
cuuaguggcu gaaaauggca                                                   20


<210>  20562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20562
ccaauuaccu uuuaacuuag                                                   20


<210>  20563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20563
aauuaccuuu uaacuuagcu                                                   20


<210>  20564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20564
uaaaaaaaaa auugaacaaa                                                   20


<210>  20565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20565
gucucuuaaa aaaaaaauug                                                   20


<210>  20566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20566
cucuuuugcc caggcuggag                                                   20


<210>  20567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20567
uuugcccagg cuggagugca                                                   20


<210>  20568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20568
agccugggca aaagagugag                                                   20


<210>  20569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20569
cugcagcccc aaacuccugg                                                   20


<210>  20570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20570
ugggcucaag cgaucccccu                                                   20


<210>  20571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20571
cacgcugcua aaucaaguuc                                                   20


<210>  20572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20572
guccguaaau ugacaguucc                                                   20


<210>  20573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20573
ccacccccag gucuaggcag                                                   20


<210>  20574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20574
ucaccacccc caggucuagg                                                   20


<210>  20575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20575
cguggcuccu caccaccccc                                                   20


<210>  20576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20576
ucacguggcu ccucaccacc                                                   20


<210>  20577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20577
uggggccuga agcgcugugc                                                   20


<210>  20578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20578
ucuguaacac ggggucuguc                                                   20


<210>  20579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20579
guaacacggg gucugucccg                                                   20


<210>  20580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20580
ucuguaacac ggggucuguc                                                   20


<210>  20581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20581
guaacacggg gucugucccc                                                   20


<210>  20582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20582
ucuguaacac ggggucuguc                                                   20


<210>  20583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20583
guaacacggg gucugucccg                                                   20


<210>  20584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20584
cucugcacag auuuaaaaac                                                   20


<210>  20585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20585
gcacagauuu aaaaaccaca                                                   20


<210>  20586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20586
acuugauauu uacuucuguu                                                   20


<210>  20587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20587
ccaaaccuca acaucccccu                                                   20


<210>  20588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20588
cugggucccu ccccaaaccu                                                   20


<210>  20589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20589
cacugggucc cuccccaaac                                                   20


<210>  20590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20590
cucacugggu cccuccccaa                                                   20


<210>  20591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20591
agaggcugga cccaguggga                                                   20


<210>  20592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20592
ugaggcucuc ucacuggguc                                                   20


<210>  20593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20593
ccgcuguacc ccacuugccg                                                   20


<210>  20594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20594
ugcuggacuc cccgcuguac                                                   20


<210>  20595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20595
ccuugcaugg uggccacacc                                                   20


<210>  20596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20596
guacggcgac cuaggcaggg                                                   20


<210>  20597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20597
caucccugcu ggcuguuggc                                                   20


<210>  20598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20598
ggccaacagc cagcagggau                                                   20


<210>  20599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20599
cugaccccaa accccaucac                                                   20


<210>  20600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20600
aaaaaagcac cuggaaucca                                                   20


<210>  20601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20601
ucauuuuagg caacuaagca                                                   20


<210>  20602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20602
uuuuaggcaa cuaagcaaug                                                   20


<210>  20603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20603
caaaauaauc acauaaguuc                                                   20


<210>  20604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20604
gauuucggca gaauauuccc                                                   20


<210>  20605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20605
uucuggcaau uuaaauugcu                                                   20


<210>  20606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20606
uuaaagauca cuuuaaaaag                                                   20


<210>  20607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20607
ucugcaagac ucuuuaaaga                                                   20


<210>  20608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20608
ggccugcugu guagucucuu                                                   20


<210>  20609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20609
uuaauaauga gcuguucguu                                                   20


<210>  20610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20610
uuauuaaaga gcccaucuuu                                                   20


<210>  20611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20611
uuguucccuu ggagccauau                                                   20


<210>  20612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20612
uggucuugga agcucaucag                                                   20


<210>  20613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20613
ucagaauguu uagagcuggg                                                   20


<210>  20614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20614
aaacauucug augagcuucc                                                   20


<210>  20615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20615
ccagcucuaa acauucugau                                                   20


<210>  20616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20616
aaacgcccau ugccugggcc                                                   20


<210>  20617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20617
gcacccuugg gggcgacggc                                                   20


<210>  20618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20618
acacuccgca cccuuggggg                                                   20


<210>  20619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20619
cccgggcaac cuccacacuc                                                   20


<210>  20620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20620
gcugcgucau gagagggagc                                                   20


<210>  20621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20621
ugacgcagcu gagcacacag                                                   20


<210>  20622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20622
caugacgcag cugagcacac                                                   20


<210>  20623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20623
cucucaugac gcagcugagc                                                   20


<210>  20624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20624
gagcuggaga ccagauacuu                                                   20


<210>  20625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20625
gaggcccacg aaauccgcag                                                   20


<210>  20626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20626
agcucggagg cccacgaaau                                                   20


<210>  20627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20627
ugaagaugua gugaaauuaa                                                   20


<210>  20628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20628
gguguccuuc acauggugau                                                   20


<210>  20629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20629
augaaggaaa aggcuggcug                                                   20


<210>  20630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20630
guuuauaccu agugcuuuag                                                   20


<210>  20631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20631
gcucuguuua uaccuagugc                                                   20


<210>  20632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20632
cucugcucug uuuauaccua                                                   20


<210>  20633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20633
acgacucgcu cugcucuguu                                                   20


<210>  20634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20634
gguuuucaaa aaucauauug                                                   20


<210>  20635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20635
cacaaaggcu cggguuuuca                                                   20


<210>  20636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20636
gaauugcucg cacaaaggcu                                                   20


<210>  20637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20637
gaaagggauc uuuguuucaa                                                   20


<210>  20638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20638
auuugauguu ggacaugaaa                                                   20


<210>  20639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20639
uuagaaagca uguugggauu                                                   20


<210>  20640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20640
auugagcuuc cuuccacgag                                                   20


<210>  20641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20641
auggagccua aguagcccac                                                   20


<210>  20642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20642
uggaaggaag cucaauggag                                                   20


<210>  20643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20643
aaccuggagu ccgacagcuu                                                   20


<210>  20644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20644
agguuggagc ucguggaagg                                                   20


<210>  20645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20645
gcccgcaggc gccgcaugca                                                   20


<210>  20646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20646
cuggugacca ugaagaucau                                                   20


<210>  20647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20647
gcugcacaca gucgugcaug                                                   20


<210>  20648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20648
agccuuguca gugcucagcu                                                   20


<210>  20649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20649
gccacgacuc cagccuuguc                                                   20


<210>  20650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20650
gccggguacu cggccacgac                                                   20


<210>  20651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20651
cgucgucauu cgucugcaug                                                   20


<210>  20652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20652
ugggccaggc ucccgucguc                                                   20


<210>  20653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20653
uccugggcca ggcucccguc                                                   20


<210>  20654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20654
uccuccuggg ccaggcuccc                                                   20


<210>  20655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20655
gcgguuuggg uuugagugca                                                   20


<210>  20656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20656
aacccaaacc gccgagcaau                                                   20


<210>  20657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20657
cuccccgucc ugcaguucau                                                   20


<210>  20658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20658
ccguccugca guucaucucu                                                   20


<210>  20659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20659
guccuguacc gagacauggg                                                   20


<210>  20660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20660
guacaggaca gagaugaacu                                                   20


<210>  20661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20661
cccaugucuc gguacaggac                                                   20


<210>  20662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20662
aucagcucac ccaugucucg                                                   20


<210>  20663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20663
ugguggaagu ucccaaugcc                                                   20


<210>  20664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20664
uccuggugga aguucccaau                                                   20


<210>  20665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20665
ucuccuccug guggaaguuc                                                   20


<210>  20666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20666
cacccagguc caccacaagg                                                   20


<210>  20667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20667
agcagacacg gccccggagg                                                   20


<210>  20668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20668
agcucccacc cagguccacc                                                   20


<210>  20669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20669
ggggccgugu cugcucgagc                                                   20


<210>  20670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20670
cacccacacc gucccacgcg                                                   20


<210>  20671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20671
cuggacuggg cccuucuguc                                                   20


<210>  20672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20672
cuucgggguc cggacagaag                                                   20


<210>  20673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20673
aauggggggc ucccuucggg                                                   20


<210>  20674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20674
ucagacugac agguucuggg                                                   20


<210>  20675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20675
ccuguggagg ugcccccagc                                                   20


<210>  20676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20676
uguggaggug cccccagcuu                                                   20


<210>  20677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20677
acaggagagg cuggcccuag                                                   20


<210>  20678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20678
aggaagcugg gggcaccucc                                                   20


<210>  20679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20679
ucaaggaagc ugggggcacc                                                   20


<210>  20680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20680
guccccccuu ccaagagggg                                                   20


<210>  20681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20681
uggaaggggg gacugagcuc                                                   20


<210>  20682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20682
cgguccacgu gcuccgggag                                                   20


<210>  20683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20683
gggaguggca gugcggacac                                                   20


<210>  20684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20684
cggagcacgu ggaccgggag                                                   20


<210>  20685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20685
uacacagauu ccaccgaugg                                                   20


<210>  20686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20686
uaugagcaag auccccgcag                                                   20


<210>  20687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20687
uaggaggggg cagugugccg                                                   20


<210>  20688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20688
acccuguagc ggucugcggg                                                   20


<210>  20689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20689
ucggggcauu cagcgggggc                                                   20


<210>  20690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20690
cucuucgggg cauucagcgg                                                   20


<210>  20691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20691
uggcaggcuu accuuuuuau                                                   20


<210>  20692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20692
gcgcggaggc ccggccuccu                                                   20


<210>  20693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20693
gcgcugagug gcuccuggca                                                   20


<210>  20694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20694
ucacuuagca gucacgggga                                                   20


<210>  20695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20695
ugcuggacaa agucccuucc                                                   20


<210>  20696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20696
cacacuggca gcaccgccuc                                                   20


<210>  20697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20697
ggaaggacuu ccuccagcca                                                   20


<210>  20698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20698
ggcuguuuac gauguaaaga                                                   20


<210>  20699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20699
ggaugugaac aaacacuaaa                                                   20


<210>  20700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20700
aaggcugcug gcuggguagg                                                   20


<210>  20701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20701
ccuaacuaca cagggaggcc                                                   20


<210>  20702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20702
ccaguuagag cagcagaagc                                                   20


<210>  20703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20703
aacuggggag gcuaugggau                                                   20


<210>  20704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20704
ugaccccugg aagcuucugc                                                   20


<210>  20705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20705
uccuugucag cuucucccuc                                                   20


<210>  20706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20706
cuccucuggg gaggagcaag                                                   20


<210>  20707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20707
ucuggggagg agcaaggaag                                                   20


<210>  20708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20708
ggggaggagc aaggaagggg                                                   20


<210>  20709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20709
ccagaggagg gagaagcuga                                                   20


<210>  20710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20710
uccccagagg agggagaagc                                                   20


<210>  20711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20711
ccuuccuugc uccuccccag                                                   20


<210>  20712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20712
gcuccccuuc cuugcuccuc                                                   20


<210>  20713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20713
ccaaagaggu uuucuaguuu                                                   20


<210>  20714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20714
uuggugagca auuuggcaaa                                                   20


<210>  20715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20715
cucucucucu cucucucucu                                                   20


<210>  20716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20716
cucucucucu cucucucucu                                                   20


<210>  20717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20717
uucaauaaaa aagggggcau                                                   20


<210>  20718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20718
acaguguuca uuucacccag                                                   20


<210>  20719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20719
cguugccaag cuggaaaagg                                                   20


<210>  20720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20720
gggaccaaaa ucuguggcuc                                                   20


<210>  20721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20721
aagcuggugg aagcuaucaa                                                   20


<210>  20722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20722
cuugucuucc aaguuaaccu                                                   20


<210>  20723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20723
acugucgccu ucacacaggu                                                   20


<210>  20724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20724
uugguccugc gggcuugacg                                                   20


<210>  20725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20725
ucaggccuuc ccuugacagu                                                   20


<210>  20726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20726
ggacgcaggc aggcaggaag                                                   20


<210>  20727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20727
gugggagcca cgucacgugc                                                   20


<210>  20728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20728
cacugagcug guugucuucc                                                   20


<210>  20729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20729
gcggguggug aucgcacgug                                                   20


<210>  20730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20730
uucuccacca agguugugac                                                   20


<210>  20731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20731
accaagguug ugacaguauc                                                   20


<210>  20732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20732
uaguggggau guccccugug                                                   20


<210>  20733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20733
gcuucuucuc uugcuugucu                                                   20


<210>  20734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20734
ugcuugucuc ugguugguac                                                   20


<210>  20735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20735
gguugguacu gugggccagc                                                   20


<210>  20736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20736
ggccacaggc agcuacccaa                                                   20


<210>  20737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20737
ugugauugac ugguucaccc                                                   20


<210>  20738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20738
augaauggcu gaaagcaccu                                                   20


<210>  20739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20739
gacguccauc uucuuggcca                                                   20


<210>  20740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20740
uccuucccuu uggccuucuu                                                   20


<210>  20741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20741
uucccuuugg ccuucuuccc                                                   20


<210>  20742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20742
agcuaccuaa gaugcugaaa                                                   20


<210>  20743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20743
ucuccagcua ccuaagaugc                                                   20


<210>  20744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20744
ggaguuuuau caguguuuua                                                   20


<210>  20745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20745
agagcuacau ggguaggaag                                                   20


<210>  20746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20746
agcuaccaaa aauucauuca                                                   20


<210>  20747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20747
auuugaccuc cagcuaccaa                                                   20


<210>  20748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20748
cuauuugacc uccagcuacc                                                   20


<210>  20749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20749
caagaaaauu cccacucucu                                                   20


<210>  20750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20750
ucccaagaaa auucccacuc                                                   20


<210>  20751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20751
aagcaugcau aaaucaccuu                                                   20


<210>  20752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20752
agcagcacau caaaaagaua                                                   20


<210>  20753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20753
uauucaacau aguacuggaa                                                   20


<210>  20754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20754
ggcuaggacu uccaguacua                                                   20


<210>  20755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20755
ugccugacug cucuggcuag                                                   20


<210>  20756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20756
aauugguaug ccuuuuauuu                                                   20


<210>  20757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20757
ucucuaauug guaugccuuu                                                   20


<210>  20758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20758
ucuucucuaa uugguaugcc                                                   20


<210>  20759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20759
cucugucacc caggcuggag                                                   20


<210>  20760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20760
gucacccagg cuggagcaca                                                   20


<210>  20761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20761
agccugggug acagagcgag                                                   20


<210>  20762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20762
aacucuugga cucaagggau                                                   20


<210>  20763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20763
uggacucaag ggauccuccc                                                   20


<210>  20764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20764
agggauccuc ccgccucagc                                                   20


<210>  20765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20765
cgccucagcc ucccaaguag                                                   20


<210>  20766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20766
gccucccaag uagcuagaac                                                   20


<210>  20767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20767
caaguagcua gaacuacagg                                                   20


<210>  20768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20768
gcuagaucau uauugguaua                                                   20


<210>  20769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20769
uuuuugguuc cauauaaauu                                                   20


<210>  20770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20770
agcuuuguuc uuuuugcuua                                                   20


<210>  20771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20771
auuuuguugu cuaguuuuau                                                   20


<210>  20772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20772
cccuugucua cuaaccaugu                                                   20


<210>  20773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20773
cauccagacu ggacaugguu                                                   20


<210>  20774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20774
aaggggaagu ugucaggcca                                                   20


<210>  20775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20775
uuguacugga aaagcagcgu                                                   20


<210>  20776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20776
cauuguacug gaaaagcagc                                                   20


<210>  20777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20777
cgccuguaau cccggcacuu                                                   20


<210>  20778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20778
aguaguaaua aauguauuaa                                                   20


<210>  20779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20779
cuuuuucccc uuaaaguuuc                                                   20


<210>  20780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20780
gguugaagca uuuacaauuu                                                   20


<210>  20781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20781
augaaugcaa aauaacaaag                                                   20


<210>  20782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20782
ggaaugcaag uauggucuau                                                   20


<210>  20783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20783
aacacagacu uuaaaauuau                                                   20


<210>  20784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20784
cucaaacaca gacuuuaaaa                                                   20


<210>  20785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20785
uacuuucccu ucucauuauc                                                   20


<210>  20786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20786
caaaacaaaa aauuaauggu                                                   20


<210>  20787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20787
uccuucucuu uucccucccu                                                   20


<210>  20788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20788
uuucccuccc uuucuucucc                                                   20


<210>  20789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20789
cuuucuucuc cuuuuccucg                                                   20


<210>  20790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20790
uuuuccucgu auauugaauc                                                   20


<210>  20791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20791
uauauugaau cuuauauuuu                                                   20


<210>  20792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20792
cuccagagga uuucaauaac                                                   20


<210>  20793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20793
agaggauuuc aauaacuuuu                                                   20


<210>  20794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20794
ggagggagga uaaaaauaaa                                                   20


<210>  20795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20795
agaagaagau caggcagaug                                                   20


<210>  20796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20796
augugccagu cacccaacac                                                   20


<210>  20797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20797
gggauauuac ugcauucuuc                                                   20


<210>  20798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20798
cucccugcuu ucuugccuua                                                   20


<210>  20799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20799
cugcuuucuu gccuuauguu                                                   20


<210>  20800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20800
acuuaaaugu cuuuucaugu                                                   20


<210>  20801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20801
gugcggcagg aagaauucca                                                   20


<210>  20802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20802
caccuguaau cccagcacuu                                                   20


<210>  20803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20803
ggggcagcca cgucacagau                                                   20


<210>  20804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20804
gauaaaaacc aguuccugcg                                                   20


<210>  20805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20805
gccgcaggaa cugguuuuua                                                   20


<210>  20806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20806
uuccccuucc uggccaauga                                                   20


<210>  20807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20807
uuggccagga aggggaaaga                                                   20


<210>  20808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20808
cauuggccag gaaggggaaa                                                   20


<210>  20809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20809
ucacuguccu cucauuggcc                                                   20


<210>  20810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20810
gaagcuggcc ccaggugguc                                                   20


<210>  20811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20811
cacagugccu gucagggggc                                                   20


<210>  20812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20812
ggcacccaaa guaagccccc                                                   20


<210>  20813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20813
gcgggggagg aggaugcgca                                                   20


<210>  20814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20814
cccgcagagu cuguccucug                                                   20


<210>  20815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20815
ucccccgcag agucuguccu                                                   20


<210>  20816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20816
cagccugccg gcaagggcaa                                                   20


<210>  20817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20817
gcacagggcc ccagcccugc                                                   20


<210>  20818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20818
uguuaaaacc cauacagugu                                                   20


<210>  20819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20819
gggacacaca cuguaugggu                                                   20


<210>  20820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20820
uuuuccuugg uccccucccc                                                   20


<210>  20821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20821
cccuugggag guuccucugg                                                   20


<210>  20822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20822
caagggggag gggaccaagg                                                   20


<210>  20823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20823
gggccucacu uguuuggacu                                                   20


<210>  20824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20824
cuuguuugga cuuuggcgug                                                   20


<210>  20825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20825
acuucucggg aguggccagg                                                   20


<210>  20826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20826
ggaguggcca ggagguacca                                                   20


<210>  20827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20827
cgagaagugg aggucacugg                                                   20


<210>  20828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20828
uggccacucc cgagaagugg                                                   20


<210>  20829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20829
uucgcucccc uggcccuggc                                                   20


<210>  20830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20830
ccuggcccug gcagcccucg                                                   20


<210>  20831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20831
ccuuggcaga gaggaggaca                                                   20


<210>  20832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20832
gccaaggcga gggcugccag                                                   20


<210>  20833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20833
cugccaaggc gagggcugcc                                                   20


<210>  20834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20834
ucucugccaa ggcgagggcu                                                   20


<210>  20835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20835
cagacggccu ggcaaggacc                                                   20


<210>  20836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20836
gcugcuaucu aggcaggaac                                                   20


<210>  20837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20837
ggagcuccau ucugcucacc                                                   20


<210>  20838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20838
agaggcugga caaacccgug                                                   20


<210>  20839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20839
auucugcuca cccccucuca                                                   20


<210>  20840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20840
cccccucuca cuuccuggca                                                   20


<210>  20841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20841
cacuuccugg cauccguguc                                                   20


<210>  20842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20842
cuuccuggca uccguguccc                                                   20


<210>  20843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20843
ccaggggaca cggaugccag                                                   20


<210>  20844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20844
ucugauuccu cuccuuccug                                                   20


<210>  20845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20845
ccuuccuggg cugaguccug                                                   20


<210>  20846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20846
uuccugggcu gaguccuggg                                                   20


<210>  20847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20847
gcccaggaag gagaggaauc                                                   20


<210>  20848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20848
gcgcccuggg cccuuccugc                                                   20


<210>  20849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20849
cguuggggcc gccguggcuu                                                   20


<210>  20850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20850
uggcucagcu gacugucucg                                                   20


<210>  20851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20851
gcugacuguc ucgaguucuc                                                   20


<210>  20852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20852
aguucucggc cuccuccugg                                                   20


<210>  20853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20853
agacagucag cugagccagg                                                   20


<210>  20854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20854
gccuccuccu ggucacgcug                                                   20


<210>  20855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20855
uccuggucac gcuggccuuc                                                   20


<210>  20856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20856
uggucacgcu ggccuuccgg                                                   20


<210>  20857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20857
uucauaacuu gacuugucug                                                   20


<210>  20858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20858
ccuccagccc cuuccacugu                                                   20


<210>  20859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20859
uccagccccu uccacuguuc                                                   20


<210>  20860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20860
agccccuucc acuguuccaa                                                   20


<210>  20861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20861
gaggcgucuc cccaacccuc                                                   20


<210>  20862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20862
gaggaagggg cuuggaacag                                                   20


<210>  20863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20863
ccaacccucc ugcugguggc                                                   20


<210>  20864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20864
ugcugguggc cgcucuugca                                                   20


<210>  20865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20865
ugcacugcuu gggugggcgg                                                   20


<210>  20866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20866
gggcuugacu ccucugcugc                                                   20


<210>  20867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20867
ucugcugcca cccugagugg                                                   20


<210>  20868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20868
gcugccaccc ugagugguca                                                   20


<210>  20869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20869
ggguggcagc agaggaguca                                                   20


<210>  20870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20870
cuaggccccg uuccacuccu                                                   20


<210>  20871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20871
aggccccguu ccacuccugu                                                   20


<210>  20872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20872
ugugggaggg cagugaugcu                                                   20


<210>  20873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20873
cacaggagug gaacggggcc                                                   20


<210>  20874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20874
agcaucacug cccucccaca                                                   20


<210>  20875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20875
ccagcaucac ugcccuccca                                                   20


<210>  20876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20876
cgcucuccag caucacugcc                                                   20


<210>  20877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20877
ccgccccuca cgcucuccag                                                   20


<210>  20878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20878
gugccugugu gccaugacgc                                                   20


<210>  20879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20879
ggggcagcca ccaacagucc                                                   20


<210>  20880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20880
gugcccacgu gccgugacgc                                                   20


<210>  20881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20881
uguugggugu caccuaguuu                                                   20


<210>  20882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20882
gcccaaacua ggugacaccc                                                   20


<210>  20883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20883
cacuccgccc aaacuaggug                                                   20


<210>  20884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20884
ugacucauug ggccgucugg                                                   20


<210>  20885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20885
uugggccguc uggcuuuccc                                                   20


<210>  20886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20886
accuggagag ugccucugag                                                   20


<210>  20887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20887
agguggaggu gucccgggaa                                                   20


<210>  20888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20888
ccagguggag gugucccggg                                                   20


<210>  20889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20889
gagaaccucc cagagucugc                                                   20


<210>  20890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20890
gaggcacucu ccagguggag                                                   20


<210>  20891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20891
cagagucugc cccuuguguu                                                   20


<210>  20892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20892
gggagguucu cagaggcacu                                                   20


<210>  20893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20893
gauggacuuu ucguuuccug                                                   20


<210>  20894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20894
aggaaacgaa aaguccaucu                                                   20


<210>  20895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20895
ugacaaaacu ccaggaaacg                                                   20


<210>  20896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20896
ugucucucuc ucuuuucuuu                                                   20


<210>  20897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20897
cucucuuuuc uuucagucug                                                   20


<210>  20898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20898
cucuuuucuu ucagucugca                                                   20


<210>  20899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20899
cuuuucuuuc agucugcaac                                                   20


<210>  20900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20900
uuucuuucag ucugcaacug                                                   20


<210>  20901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20901
ggaaggacgg guuguuugcc                                                   20


<210>  20902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20902
uugugggcgg guucuaggug                                                   20


<210>  20903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20903
ccuagaaccc gcccacaagg                                                   20


<210>  20904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20904
gcguguguuu uggaagcugu                                                   20


<210>  20905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20905
uaacaaacag cuuccaaaac                                                   20


<210>  20906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20906
aucacacugg uguucagggc                                                   20


<210>  20907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20907
gacacacagc gcucuaucac                                                   20


<210>  20908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20908
ucagacacac agcgcucuau                                                   20


<210>  20909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20909
ucccuuguug uauaaccagc                                                   20


<210>  20910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20910
aauucagaaa gcacuuugaa                                                   20


<210>  20911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20911
cccaaauuuc cugaauugcu                                                   20


<210>  20912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20912
agaaaaguau aauagacgaa                                                   20


<210>  20913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20913
auucgucuau uauacuuuuc                                                   20


<210>  20914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20914
caauucgucu auuauacuuu                                                   20


<210>  20915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20915
ucaucccaca cucucaauuc                                                   20


<210>  20916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20916
gaugucaucc uuaucauuuu                                                   20


<210>  20917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20917
ccaaaguaag gagaguuccu                                                   20


<210>  20918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20918
aaaguaagga gaguuccucc                                                   20


<210>  20919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20919
uuacuuugga gagguuuuuu                                                   20


<210>  20920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20920
ccuuacuuug gagagguuuu                                                   20


<210>  20921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20921
gaaauauucc ucuuuucuuc                                                   20


<210>  20922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20922
uuucuucuaa cacuccugac                                                   20


<210>  20923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20923
ugacaguccg caggcucucg                                                   20


<210>  20924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20924
cggguuucau cgucaccuca                                                   20


<210>  20925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20925
gguuucaucg ucaccucacg                                                   20


<210>  20926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20926
cgcuuuuguc cccacuucug                                                   20


<210>  20927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20927
gggacagaag uggggacaaa                                                   20


<210>  20928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20928
cagggacaga aguggggaca                                                   20


<210>  20929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20929
gcccaucccu ggcccacagc                                                   20


<210>  20930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20930
aacccaccgg ccccugggca                                                   20


<210>  20931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20931
uuaacgcaca aauacagugg                                                   20


<210>  20932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20932
cacuuucugu gguccugcag                                                   20


<210>  20933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20933
cuuucugugg uccugcagcu                                                   20


<210>  20934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20934
guccucggcc ucggaaaggg                                                   20


<210>  20935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20935
gccucggaaa gggcugcugu                                                   20


<210>  20936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20936
gaaagggcug cuguccccag                                                   20


<210>  20937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20937
gucugccuac cuggggacag                                                   20


<210>  20938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20938
gagcccucgc aggccagcca                                                   20


<210>  20939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20939
gagcucuguc ugccuaccug                                                   20


<210>  20940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20940
caggccagcc acucuguagg                                                   20


<210>  20941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20941
guaggaaggc caggaggacc                                                   20


<210>  20942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20942
uggccuuccu acagaguggc                                                   20


<210>  20943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20943
gucugcccac cugggguccu                                                   20


<210>  20944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20944
gagcccuugu gggccagcgg                                                   20


<210>  20945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20945
gagcucuguc ugcccaccug                                                   20


<210>  20946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20946
guaggaggag gagcauaucu                                                   20


<210>  20947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20947
uacagagccg cuggcccaca                                                   20


<210>  20948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20948
uccuacagag ccgcuggccc                                                   20


<210>  20949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20949
uccuccuaca gagccgcugg                                                   20


<210>  20950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20950
gcuucaggug ccagugcgug                                                   20


<210>  20951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20951
ggucucggcu ucaggugcca                                                   20


<210>  20952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20952
ugugguggag auguauuuug                                                   20


<210>  20953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20953
accacacgag ugucgggauc                                                   20


<210>  20954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20954
accuuaagac ugauuaaaug                                                   20


<210>  20955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20955
cuccaccuua agacugauua                                                   20


<210>  20956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20956
uucugccgug uucucacuuc                                                   20


<210>  20957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20957
cuucuccuuu cuggcagaag                                                   20


<210>  20958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20958
uuucuggcag aagacauuca                                                   20


<210>  20959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20959
aaaagauugc uucugucagc                                                   20


<210>  20960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20960
ggguuccugc aucuauugcu                                                   20


<210>  20961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20961
caaggguggg aagucucuag                                                   20


<210>  20962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20962
agcuccucgc cgugcuggcu                                                   20


<210>  20963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20963
ucgccgugcu ggcucugugu                                                   20


<210>  20964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20964
ccgugcuggc ucuguguguc                                                   20


<210>  20965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20965
gugugucccu cugaggaagu                                                   20


<210>  20966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20966
gaggaagugu guccuggcuc                                                   20


<210>  20967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20967
gagggacaca cagagccagc                                                   20


<210>  20968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20968
ucgccacgcu ggcucugugu                                                   20


<210>  20969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20969
ccacgcuggc ucuguguguc                                                   20


<210>  20970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20970
gugugucccu cugaggaagu                                                   20


<210>  20971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20971
gaggaagugu auccuggcca                                                   20


<210>  20972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20972
gagggacaca cagagccagc                                                   20


<210>  20973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20973
gcguggccag gauacacuuc                                                   20


<210>  20974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20974
uccuucuuuu cccaguguca                                                   20


<210>  20975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20975
uucuuuuccc agugucagac                                                   20


<210>  20976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20976
auggagagcc ccagucacag                                                   20


<210>  20977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20977
auggagggac gggccugucc                                                   20


<210>  20978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20978
ccauggaggg acgggccugu                                                   20


<210>  20979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20979
gugacugggg cucuccaugg                                                   20


<210>  20980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20980
ucugugacug gggcucucca                                                   20


<210>  20981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20981
uccucuguga cuggggcucu                                                   20


<210>  20982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20982
cgucuccucc ucugugacug                                                   20


<210>  20983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20983
cucccgucuc cuccucugug                                                   20


<210>  20984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20984
ucccucccgu cuccuccucu                                                   20


<210>  20985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20985
uccucccucc cgucuccucc                                                   20


<210>  20986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20986
cgucuccucc ucccucccgu                                                   20


<210>  20987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20987
cucccgucuc cuccucccuc                                                   20


<210>  20988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20988
ucccucccgu cuccuccucc                                                   20


<210>  20989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20989
uccucccucc cgucuccucc                                                   20


<210>  20990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20990
cgucuccucc ucccucccgu                                                   20


<210>  20991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20991
cucccgucuc cuccucccuc                                                   20


<210>  20992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20992
ucccucccgu cuccuccucc                                                   20


<210>  20993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20993
uccucccucc cgucuccucc                                                   20


<210>  20994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20994
cgucuccucc ucccucccgu                                                   20


<210>  20995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20995
cucccgucuc cuccucccuc                                                   20


<210>  20996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20996
ucccucccgu cuccuccucc                                                   20


<210>  20997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20997
uauaagcaaa gaaacugaag                                                   20


<210>  20998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20998
uuuuacucuu auaagcaaag                                                   20


<210>  20999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  20999
ugugcacauu aaacaagaua                                                   20


<210>  21000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21000
agaucggugu cacauucugc                                                   20


<210>  21001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21001
gugcccuaca ucuaacaacg                                                   20


<210>  21002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21002
gccucggugc ccuacaucua                                                   20


<210>  21003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21003
ccacucugcc ucggugcccu                                                   20


<210>  21004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21004
caguagucug caggugagau                                                   20


<210>  21005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21005
ccugcagacu acugugagcu                                                   20


<210>  21006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21006
ggccugcagg ggaaagcccu                                                   20


<210>  21007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21007
gccagggcuu uccccugcag                                                   20


<210>  21008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21008
cagccagggc uuuccccugc                                                   20


<210>  21009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21009
acccuggcuc ccacccaccc                                                   20


<210>  21010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21010
cacccacccc ccagcccugg                                                   20


<210>  21011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21011
acacgcccag ccccaugguc                                                   20


<210>  21012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21012
aggaccaugg ggcugggcgu                                                   20


<210>  21013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21013
ccaggaccau ggggcugggc                                                   20


<210>  21014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21014
agcccuggac ccuccagcgc                                                   20


<210>  21015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21015
agcgccugca gccccugcug                                                   20


<210>  21016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21016
ggcagaaaga ggcccccucc                                                   20


<210>  21017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21017
uucugccuga ggcaccagaa                                                   20


<210>  21018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21018
cccacacccu gcccuccacg                                                   20


<210>  21019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21019
acggcaguga caggagccug                                                   20


<210>  21020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21020
ugucacugcc guggagggca                                                   20


<210>  21021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21021
ggcuguguuu ccacacagag                                                   20


<210>  21022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21022
guguggaaac acagccagag                                                   20


<210>  21023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21023
cacugaccac agccuauaaa                                                   20


<210>  21024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21024
gugcacugag gugggccugg                                                   20


<210>  21025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21025
gugcacugag ucucccacug                                                   20


<210>  21026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21026
agcaccccag uguuuuuaug                                                   20


<210>  21027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21027
ccgaguucca aggagggacu                                                   20


<210>  21028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21028
gggagcauuu uucccauaaa                                                   20


<210>  21029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21029
uuggaacucg gggagcauuu                                                   20


<210>  21030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21030
gucccuccuu ggaacucggg                                                   20


<210>  21031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21031
ucagucccuc cuuggaacuc                                                   20


<210>  21032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21032
ccaagccaac uccucagucc                                                   20


<210>  21033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21033
gcugggcugu cucugccugg                                                   20


<210>  21034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21034
gccuggucau ccugucuagu                                                   20


<210>  21035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21035
cuuagaaaua uuuuguguuc                                                   20


<210>  21036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21036
uugaacacaa aauauuucua                                                   20


<210>  21037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21037
cuggcacggc ucguugaaca                                                   20


<210>  21038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21038
cacuggcacg gcucguugaa                                                   20


<210>  21039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21039
cucacuggca cggcucguug                                                   20


<210>  21040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21040
cgcuggagag uuuuaguuuu                                                   20


<210>  21041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21041
cuggagaguu uuaguuuugu                                                   20


<210>  21042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21042
agcgagagcc uaagcuauaa                                                   20


<210>  21043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21043
ccagcgagag ccuaagcuau                                                   20


<210>  21044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21044
guuuuaagga aguuggacua                                                   20


<210>  21045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21045
aacuugacaa agauugccaa                                                   20


<210>  21046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21046
uuggcuacaa acggguggcc                                                   20


<210>  21047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21047
ggaaaaaggg uuacagcugg                                                   20


<210>  21048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21048
ggggggcacg gcagggcugu                                                   20


<210>  21049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21049
cugcccccac ccacagcccu                                                   20


<210>  21050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21050
agcuggaauc ugcucccugc                                                   20


<210>  21051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21051
ccagcuggaa ucugcucccu                                                   20


<210>  21052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21052
auaaugcuag aaugugcuuc                                                   20


<210>  21053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21053
cuauaaugcu agaaugugcu                                                   20


<210>  21054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21054
cacuucuguc ugaauaacuu                                                   20


<210>  21055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21055
accucacacu ucugucugaa                                                   20


<210>  21056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21056
agcucgaccu cacacuucug                                                   20


<210>  21057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21057
cuccagcucg accucacacu                                                   20


<210>  21058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21058
uuucuucaca acgccccauc                                                   20


<210>  21059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21059
uggaaaaagg aaccucucac                                                   20


<210>  21060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21060
caccucuccu ggucuggcuc                                                   20


<210>  21061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21061
ccucuccugg ucuggcucug                                                   20


<210>  21062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21062
ccuggucugg cucugcacag                                                   20


<210>  21063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21063
uggucuggcu cugcacagag                                                   20


<210>  21064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21064
gcacagagcu ggagccgcgg                                                   20


<210>  21065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21065
gugcagagcc agaccaggag                                                   20


<210>  21066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21066
agcucugugc agagccagac                                                   20


<210>  21067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21067
guuggucaag cucugugcca                                                   20


<210>  21068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21068
gugccaagag gccugccaga                                                   20


<210>  21069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21069
uggcacagag cuugaccaac                                                   20


<210>  21070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21070
cccacugcag ccuccacagg                                                   20


<210>  21071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21071
acagguggau guucccgcug                                                   20


<210>  21072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21072
ccuucugaag ucggggugug                                                   20


<210>  21073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21073
acaccccgac uucagaaggu                                                   20


<210>  21074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21074
ccgauagucu ccacaccccg                                                   20


<210>  21075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21075
cagagcgccc accuccuccu                                                   20


<210>  21076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21076
gggagcuccc cgauagucuc                                                   20


<210>  21077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21077
uccugcguac ggcgucugug                                                   20


<210>  21078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21078
ugcguacggc gucugugcca                                                   20


<210>  21079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21079
ggcuuugggg gacgguggca                                                   20


<210>  21080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21080
agcugcuucu caaacacucc                                                   20


<210>  21081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21081
aacacuccgu ucucgcagcc                                                   20


<210>  21082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21082
guucucgcag ccucacccug                                                   20


<210>  21083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21083
cagccucacc cuggggaccc                                                   20


<210>  21084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21084
cccuggggac ccccgacacg                                                   20


<210>  21085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21085
auccccaugu ccuccucaug                                                   20


<210>  21086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21086
ucaugccuug ugccucagcu                                                   20


<210>  21087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21087
ugccuugugc cucagcucug                                                   20


<210>  21088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21088
gcucugcccu gaccccacuc                                                   20


<210>  21089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21089
gcccugaccc cacucugucc                                                   20


<210>  21090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21090
guccacucag cugccccccu                                                   20


<210>  21091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21091
gcugcccccc uacucguccu                                                   20


<210>  21092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21092
uccuccaugc agaccucagu                                                   20


<210>  21093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21093
augcagaccu cagucuuggc                                                   20


<210>  21094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21094
gucuuggccc ugucucugca                                                   20


<210>  21095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21095
gcagccaucc ucccgcuccc                                                   20


<210>  21096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21096
cgcucccuuc uccugaacgc                                                   20


<210>  21097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21097
cuucuccuga acgcuggugg                                                   20


<210>  21098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21098
ugaacgcugg ugguugcccc                                                   20


<210>  21099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21099
accagcucag agccccuguu                                                   20


<210>  21100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21100
gagccccugu ucccccaacc                                                   20


<210>  21101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21101
gagcuggugg agggguccag                                                   20


<210>  21102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21102
aauggugccu caggcacaug                                                   20


<210>  21103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21103
ggcacaugcg guuucccucu                                                   20


<210>  21104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21104
ucccuuccug accaccugcc                                                   20


<210>  21105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21105
ggaugggggc agguggucag                                                   20


<210>  21106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21106
acguggcagg ucagaguugu                                                   20


<210>  21107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21107
gaccugccac guggagguca                                                   20


<210>  21108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21108
ugccagccgc ugugccgggu                                                   20


<210>  21109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21109
cgugccagcc gcugugccgg                                                   20


<210>  21110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21110
acagacagcu cucgugccag                                                   20


<210>  21111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21111
ggcugauguc ugcugaacac                                                   20


<210>  21112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21112
cccugacgcu cuggcugaug                                                   20


<210>  21113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21113
aaaagcacac acaagcacag                                                   20


<210>  21114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21114
ugugugacug guguugcggg                                                   20


<210>  21115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21115
uccugggcug cucugcgcgc                                                   20


<210>  21116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21116
ugggcugcuc ugcgcgccug                                                   20


<210>  21117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21117
gcgcgccugc caggcucuuc                                                   20


<210>  21118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21118
uccagugccu ucacccaaca                                                   20


<210>  21119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21119
aaaggcccgc guguugggug                                                   20


<210>  21120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21120
gaccuggcca uggcggaaga                                                   20


<210>  21121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21121
accugcagcu ccacagcuga                                                   20


<210>  21122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21122
acagcugaca ggccgaucuc                                                   20


<210>  21123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21123
uggggcaagu cacuuucucu                                                   20


<210>  21124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21124
cuccuagccu ugugucuuca                                                   20


<210>  21125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21125
ccuagccuug ugucuucauc                                                   20


<210>  21126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21126
uagccuugug ucuucaucuc                                                   20


<210>  21127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21127
ccgguccuug uuagcgaaca                                                   20


<210>  21128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21128
gugccuguuc gcuaacaagg                                                   20


<210>  21129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21129
ccaggccuca gugccuguuc                                                   20


<210>  21130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21130
cccaucaggc agccguuugu                                                   20


<210>  21131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21131
uuaaaauaua aaguauaauu                                                   20


<210>  21132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21132
ugcuacuuuu ggugcacacu                                                   20


<210>  21133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21133
gagggggaau uauuacacac                                                   20


<210>  21134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21134
gaguacuuac ccauguugau                                                   20


<210>  21135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21135
ugguuucuga aaaaggugug                                                   20


<210>  21136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21136
uuuuuccauu cacauacuuu                                                   20


<210>  21137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21137
augugucugu uagauuuaau                                                   20


<210>  21138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21138
cuaugugucu guuagauuua                                                   20


<210>  21139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21139
guaugcuaua auuuuuuuaa                                                   20


<210>  21140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21140
ugacagcagu guauuugaau                                                   20


<210>  21141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21141
cauuuuaauu ucuuccuuga                                                   20


<210>  21142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21142
uuuucuugau uauacuuuug                                                   20


<210>  21143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21143
cucuuuuucu ugauuauacu                                                   20


<210>  21144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21144
gcacuuuggg aggcugaugc                                                   20


<210>  21145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21145
caaagugcug agauuacagg                                                   20


<210>  21146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21146
ugcaucagcc ucccaaagug                                                   20


<210>  21147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21147
aauuccuggg cccaagugau                                                   20


<210>  21148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21148
acaaaaaaag aaaaagagga                                                   20


<210>  21149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21149
uuuucuuuuu uuguagagau                                                   20


<210>  21150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21150
uccucuuuuu cuuuuuuugu                                                   20


<210>  21151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21151
aacuguacuu aggaccuguc                                                   20


<210>  21152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21152
ucuguauauu gguuugggca                                                   20


<210>  21153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21153
aggagccagg cuauuggagc                                                   20


<210>  21154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21154
uggaggaaaa cacuuagaac                                                   20


<210>  21155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21155
aauagccugg cuccuggagg                                                   20


<210>  21156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21156
gccacaaggc cugcagugcc                                                   20


<210>  21157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21157
cagccauacu guuucacauu                                                   20


<210>  21158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21158
gccauacugu uucacauuca                                                   20


<210>  21159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21159
uaaguuacuu ggugaggagg                                                   20


<210>  21160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21160
ccaaguaacu uacgaguuac                                                   20


<210>  21161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21161
ucaccaagua acuuacgagu                                                   20


<210>  21162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21162
ccuccucacc aaguaacuua                                                   20


<210>  21163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21163
cgcugucccu gugaaguccg                                                   20


<210>  21164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21164
gacuucacag ggacagcgug                                                   20


<210>  21165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21165
ccccgcugua aaaccgcagu                                                   20


<210>  21166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21166
cugggcaaga cacucccccc                                                   20


<210>  21167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21167
uuccucacug ggcaagacac                                                   20


<210>  21168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21168
gcuccuuccu cacugggcaa                                                   20


<210>  21169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21169
gagucagauc caaacagugu                                                   20


<210>  21170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21170
gagcuccgcu ccuuccucac                                                   20


<210>  21171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21171
ggaaccacgc cgugaaccgg                                                   20


<210>  21172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21172
gccugguguu accuagucca                                                   20


<210>  21173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21173
uagaauacag cuugccauag                                                   20


<210>  21174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21174
auggcaagcu guauucuagg                                                   20


<210>  21175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21175
cgauucacag gugcugacgg                                                   20


<210>  21176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21176
uucucacgau ucacaggugc                                                   20


<210>  21177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21177
uuuaccgcau gcucaccuua                                                   20


<210>  21178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21178
ccuuaaacuu gcccacccgg                                                   20


<210>  21179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21179
uccuaaaacc gggugggcaa                                                   20


<210>  21180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21180
auggggaacc cagccauucu                                                   20


<210>  21181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21181
uccaugggga acccagccau                                                   20


<210>  21182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21182
ccuccauggg gaacccagcc                                                   20


<210>  21183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21183
ucucuugcug cguaaaaguc                                                   20


<210>  21184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21184
ugcugcguaa aaguccaggg                                                   20


<210>  21185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21185
gcaaagcccu ggacuuuuac                                                   20


<210>  21186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21186
ccacagucag caaggagaag                                                   20


<210>  21187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21187
acagucagca aggagaagca                                                   20


<210>  21188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21188
uugcugacug uggagaggcu                                                   20


<210>  21189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21189
agagguggcc cccugagccc                                                   20


<210>  21190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21190
ggagacugcu ucuccuugcu                                                   20


<210>  21191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21191
gggggccacc ucuggagacu                                                   20


<210>  21192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21192
accccuggga aggggccaga                                                   20


<210>  21193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21193
agggccugcu gccugugguc                                                   20


<210>  21194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21194
cgggcuccag ggccugcugc                                                   20


<210>  21195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21195
cugggccagu ggacauggga                                                   20


<210>  21196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21196
gccauggugg ccauauaaau                                                   20


<210>  21197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21197
cagccauggu ggccauauaa                                                   20


<210>  21198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21198
acacaucagg ggcagauggu                                                   20


<210>  21199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21199
uuuuggcuua ugggguggcc                                                   20


<210>  21200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21200
aaaugucaca aauccuuuau                                                   20


<210>  21201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21201
ggcccuuccu ccuucccuga                                                   20


<210>  21202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21202
uucccugaag ccugguccuc                                                   20


<210>  21203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21203
ggccucaguc cugcugggua                                                   20


<210>  21204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21204
guccugcugg guagggugcc                                                   20


<210>  21205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21205
cuaucccugg acucuuucag                                                   20


<210>  21206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21206
aucccuggac ucuuucagug                                                   20


<210>  21207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21207
uucaguggaa gcacaggucc                                                   20


<210>  21208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21208
agccaaggug gggccaccca                                                   20


<210>  21209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21209
aaaguggucc uaaacccuuc                                                   20


<210>  21210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21210
ugaggucagc auuuggggcc                                                   20


<210>  21211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21211
ugaggaagac ucaaaagugg                                                   20


<210>  21212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21212
gcguugggug gcguccucug                                                   20


<210>  21213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21213
gcguugggug guguccucug                                                   20


<210>  21214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21214
gguggggcca agccacaacc                                                   20


<210>  21215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21215
uuuagugguu aauuccuuug                                                   20


<210>  21216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21216
aguaagcaua auaaaugaag                                                   20


<210>  21217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21217
aagaaaagac acagaacauu                                                   20


<210>  21218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21218
ggaugcucca agaaaagaca                                                   20


<210>  21219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21219
cuguggucag augugaccuc                                                   20


<210>  21220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21220
ccaacuacuu auggucauag                                                   20


<210>  21221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21221
aagccuagaa uccuaaaaau                                                   20


<210>  21222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21222
gaauuuuuag gauucuaggc                                                   20


<210>  21223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21223
ucuuugcaca ucgccuaaca                                                   20


<210>  21224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21224
ugcgaagguc agugugggaa                                                   20


<210>  21225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21225
gcucacucgc auggccucau                                                   20


<210>  21226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21226
cucgcauggc cucaugggcu                                                   20


<210>  21227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21227
cauggccuca ugggcucugg                                                   20


<210>  21228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21228
ugggcucugg cagcauuuca                                                   20


<210>  21229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21229
ggcagcauuu cacccccgcc                                                   20


<210>  21230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21230
ccagaaggac uuggugucac                                                   20


<210>  21231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21231
agaaggacuu ggugucacuu                                                   20


<210>  21232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21232
acgucugaag ugacaccaag                                                   20


<210>  21233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21233
cuacgucuga agugacacca                                                   20


<210>  21234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21234
gccagaauag uuauaaauca                                                   20


<210>  21235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21235
aggaaagacc cagaauucag                                                   20


<210>  21236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21236
uguuugggcc cacauuucuu                                                   20


<210>  21237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21237
gagguaacgg gaaguacacu                                                   20


<210>  21238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21238
gagggccaga agaaaugugg                                                   20


<210>  21239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21239
agggguccgu gagaccugcc                                                   20


<210>  21240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21240
agauauagug uacuucccgu                                                   20


<210>  21241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21241
cggaccccuc gagauauagu                                                   20


<210>  21242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21242
ucugcagggc ugugaggucu                                                   20


<210>  21243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21243
gcagggcugu gaggucuggc                                                   20


<210>  21244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21244
cagcccugca gaggagcugc                                                   20


<210>  21245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21245
cggucagccc agaaagugcu                                                   20


<210>  21246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21246
ccauggagaa uguggagucu                                                   20


<210>  21247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21247
auggugaggu cccgguaucc                                                   20


<210>  21248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21248
acauucucca uggugagguc                                                   20


<210>  21249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21249
gcagcuucau cuguaaaaug                                                   20


<210>  21250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21250
gucaaucagc ccauuuuaca                                                   20


<210>  21251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21251
gaaaaguguu uacaugcuau                                                   20


<210>  21252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21252
ucagaaaagu guuuacaugc                                                   20


<210>  21253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21253
gcaggcucug cuguuguggc                                                   20


<210>  21254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21254
gcuguugugg caggcuuuug                                                   20


<210>  21255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21255
acaaaagccu gccacaacag                                                   20


<210>  21256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21256
gcaucucaac aaaagccugc                                                   20


<210>  21257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21257
gcagccugug cugcuuaaag                                                   20


<210>  21258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21258
gcuuuaagca gcacaggcug                                                   20


<210>  21259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21259
ggcccccucu gcuuuaagca                                                   20


<210>  21260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21260
uuccuccgca agccagcccc                                                   20


<210>  21261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21261
gcaagccagc cccucacagg                                                   20


<210>  21262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21262
cagggauucc cguaagauuu                                                   20


<210>  21263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21263
cucauacagc cuuaccugau                                                   20


<210>  21264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21264
uacagccuua ccugaugggg                                                   20


<210>  21265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21265
gcugacgugu uucucuccca                                                   20


<210>  21266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21266
cccacacacc aggccacuug                                                   20


<210>  21267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21267
cacacaccag gccacuugga                                                   20


<210>  21268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21268
aaguggccug guguguggga                                                   20


<210>  21269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21269
uggacgccau cucauugggg                                                   20


<210>  21270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21270
uuggggcuca ucacaguauc                                                   20


<210>  21271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21271
ucacaguauc aagguagaag                                                   20


<210>  21272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21272
ucuaccuuga uacugugaug                                                   20


<210>  21273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21273
gcuuccucuu cuaccuugau                                                   20


<210>  21274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21274
guggccaagg gaccuguccc                                                   20


<210>  21275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21275
gccagacccc auggucgugg                                                   20


<210>  21276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21276
guggucagac aggggugcug                                                   20


<210>  21277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21277
ggucacagca gcaccccugu                                                   20


<210>  21278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21278
uuugaaggug gugacccugc                                                   20


<210>  21279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21279
uguggagccc agcugugcug                                                   20


<210>  21280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21280
acacgagggg cagggucacc                                                   20


<210>  21281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21281
gccccacagc acagcugggc                                                   20


<210>  21282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21282
ucuuucagga uguggcucug                                                   20


<210>  21283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21283
uucaggaugu ggcucuguuu                                                   20


<210>  21284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21284
guuuucacug ccuaccagcu                                                   20


<210>  21285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21285
ccagccuucc ccuugguucu                                                   20


<210>  21286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21286
agccuucccc uugguucuug                                                   20


<210>  21287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21287
aagaaccaag gggaaggcug                                                   20


<210>  21288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21288
guggccagcc uauuucucca                                                   20


<210>  21289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21289
auuugcaacc agcaacccug                                                   20


<210>  21290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21290
gaaguuauag ccagaaguuu                                                   20


<210>  21291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21291
gugccucaga aguuauagcc                                                   20


<210>  21292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21292
ugccccgcuc cgugccucag                                                   20


<210>  21293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21293
cggccagucu gggaguggca                                                   20


<210>  21294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21294
gccagucugg gaguggcagc                                                   20


<210>  21295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21295
cagacuggcc gagagcgcug                                                   20


<210>  21296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21296
uccuccugca ggaagcuucc                                                   20


<210>  21297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21297
uccugcagga agcuuccucc                                                   20


<210>  21298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21298
ugcaggaagc uuccuccacc                                                   20


<210>  21299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21299
accuuucagc agcccuggag                                                   20


<210>  21300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21300
agggcugcug aaagguggag                                                   20


<210>  21301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21301
augcggcucc agggcugcug                                                   20


<210>  21302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21302
cuucccugcu ccaugcggcu                                                   20


<210>  21303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21303
ggcauccugu guguuccagg                                                   20


<210>  21304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21304
cacacagccu ggaacacaca                                                   20


<210>  21305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21305
ugccaugccu ggcagcugca                                                   20


<210>  21306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21306
ggaaugcagc agggcccugc                                                   20


<210>  21307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21307
cccuguaggg auaagcaagu                                                   20


<210>  21308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21308
cuguagggau aagcaagugc                                                   20


<210>  21309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21309
gcaccggcug uccugggcca                                                   20


<210>  21310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21310
ccacacaucc caggccccca                                                   20


<210>  21311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21311
gugacccagc aacuguucug                                                   20


<210>  21312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21312
ugcaaggcgg gggacaccag                                                   20


<210>  21313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21313
ggugggccac aaggguuggc                                                   20


<210>  21314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21314
uggaucacag gggcaguggg                                                   20


<210>  21315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21315
ccacugcccc ugugauccaa                                                   20


<210>  21316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21316
cgaugccucu gagcccugcu                                                   20


<210>  21317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21317
gagcccugcu cugaggucag                                                   20


<210>  21318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21318
gaggcaucgg gagcccuggg                                                   20


<210>  21319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21319
gaggucagcc gauguggcuc                                                   20


<210>  21320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21320
gagcagggcu cagaggcauc                                                   20


<210>  21321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21321
guccuggcug ugaggccuca                                                   20


<210>  21322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21322
cagccaggac ugagccacau                                                   20


<210>  21323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21323
cgcugcccug auuccauuug                                                   20


<210>  21324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21324
ucagugcgag gcagacagag                                                   20


<210>  21325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21325
gugcgaggca gacagagccc                                                   20


<210>  21326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21326
cacugaggag caaauggaau                                                   20


<210>  21327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21327
gucugccucg cacugaggag                                                   20


<210>  21328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21328
ucccuaacgg gacacugucu                                                   20


<210>  21329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21329
cuaacgggac acugucuacc                                                   20


<210>  21330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21330
cccgagaacc gucagccccg                                                   20


<210>  21331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21331
ggggagaaga aggaaggggu                                                   20


<210>  21332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21332
cggggcugac gguucucggg                                                   20


<210>  21333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21333
guccacaugc ccuacccuag                                                   20


<210>  21334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21334
ccacugcugu ucccguaucu                                                   20


<210>  21335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21335
accacccugg gguuggggac                                                   20


<210>  21336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21336
cggauggggc ugacacccaa                                                   20


<210>  21337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21337
gauggggcug acacccaagg                                                   20


<210>  21338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21338
cugcagaaga accuggaugu                                                   20


<210>  21339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21339
gcagaagaac cuggauguga                                                   20


<210>  21340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21340
ggccugggca uuagauguca                                                   20


<210>  21341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21341
aguccagcug uccccaagcu                                                   20


<210>  21342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21342
uugacccugu ggcuccaguc                                                   20


<210>  21343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21343
cccuccuuga cccuguggcu                                                   20


<210>  21344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21344
cagcugggug gacuuugcgc                                                   20


<210>  21345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21345
ucugcccauc ggagccggcu                                                   20


<210>  21346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21346
gcccaucgga gccggcuggc                                                   20


<210>  21347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21347
gaugggcaga ggagcugccu                                                   20


<210>  21348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21348
ugccugggau gggggcagaa                                                   20


<210>  21349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21349
ucugccccca ucccaggcaa                                                   20


<210>  21350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21350
accucuucug cccccauccc                                                   20


<210>  21351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21351
gggccccagg ucuccaccuc                                                   20


<210>  21352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21352
auuucuguuc ccauuaaaag                                                   20


<210>  21353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21353
uccuccauuu cuguucccau                                                   20


<210>  21354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21354
gucucuuccu ccauuucugu                                                   20


<210>  21355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21355
ccgaccccua cugccugccu                                                   20


<210>  21356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21356
ccaggcaggc aguagggguc                                                   20


<210>  21357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21357
guguggggga agccugggga                                                   20


<210>  21358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21358
cauccccagg cuucccccac                                                   20


<210>  21359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21359
cacaucccca ggcuuccccc                                                   20


<210>  21360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21360
caacuuuaaa guuggucuuc                                                   20


<210>  21361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21361
gggcacugcu cccaacuuua                                                   20


<210>  21362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21362
gcuuuuugaa aaagaagucc                                                   20


<210>  21363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21363
gaccagcgcc uggcggggcg                                                   20


<210>  21364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21364
gacgcucaga ccagcgccug                                                   20


<210>  21365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21365
agagggcggg cggcuccagu                                                   20


<210>  21366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21366
ggagcaagcg caccaucugg                                                   20


<210>  21367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21367
aguggccgcc gcgggacggu                                                   20


<210>  21368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21368
ggccccaccg ucccgcggcg                                                   20


<210>  21369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21369
cccaccccca cgggccccuc                                                   20


<210>  21370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21370
ugcgggcggc ucccccaccc                                                   20


<210>  21371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21371
uucuccugcg ggcggcuccc                                                   20


<210>  21372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21372
agggccggcg cgggcggggc                                                   20


<210>  21373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21373
uggcccagcc cagggcccug                                                   20


<210>  21374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21374
cagggcccug ggcugggcca                                                   20


<210>  21375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21375
ccccggcgcc ccagcccagg                                                   20


<210>  21376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21376
gucaucuucu gucaugguuc                                                   20


<210>  21377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21377
accagcgccg ccucggucau                                                   20


<210>  21378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21378
cgcucccccc uguccccgca                                                   20


<210>  21379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21379
ccccuguccc cgcaguggaa                                                   20


<210>  21380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21380
uccacugcgg ggacaggggg                                                   20


<210>  21381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21381
ccugccacgg gcgacggcuu                                                   20


<210>  21382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21382
guaacccgug ucgcuacccc                                                   20


<210>  21383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21383
gguuucccgg cggggugaca                                                   20


<210>  21384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21384
cggguuuccc ggcgggguga                                                   20


<210>  21385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21385
caggggcgcc gggggguccg                                                   20


<210>  21386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21386
uuccagcagg gcagacugag                                                   20


<210>  21387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21387
gucugcccug cuggaaagag                                                   20


<210>  21388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21388
ggccucaguc ugcccugcug                                                   20


<210>  21389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21389
gccuacaggg ccaccaggca                                                   20


<210>  21390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21390
gggccugcgu ccccuccgcc                                                   20


<210>  21391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21391
gcuggggggc ucagggccug                                                   20


<210>  21392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21392
gguauguggg gcuuugcuuc                                                   20


<210>  21393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21393
acccucaggu auguggggcu                                                   20


<210>  21394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21394
gagcagggcc cccgaaccca                                                   20


<210>  21395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21395
gagcguuucc acaagcacag                                                   20


<210>  21396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21396
aggggugcug cguggguuag                                                   20


<210>  21397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21397
caggcagacg agaggcuggg                                                   20


<210>  21398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21398
ucugccuggg agggguccag                                                   20


<210>  21399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21399
cgucugccug ggaggggucc                                                   20


<210>  21400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21400
gcccugcccu accgcagccc                                                   20


<210>  21401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21401
gggaggaggc aggggucccc                                                   20


<210>  21402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21402
cagaggacug uucccccagc                                                   20


<210>  21403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21403
ucccagagga cuguuccccc                                                   20


<210>  21404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21404
gggcggggac ugggggggga                                                   20


<210>  21405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21405
ccaagcuggg gugcuggcuc                                                   20


<210>  21406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21406
augcugaccc uccccaagcu                                                   20


<210>  21407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21407
cuacaggccc agcgcugcag                                                   20


<210>  21408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21408
gcccucccua caggcccagc                                                   20


<210>  21409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21409
agaggacagg ugcggcagag                                                   20


<210>  21410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21410
ggagcagcug caggcccggc                                                   20


<210>  21411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21411
gccgcaccug uccucuggag                                                   20


<210>  21412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21412
gccugugugc auggggggcu                                                   20


<210>  21413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21413
ggcagccccc uggcguacag                                                   20


<210>  21414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21414
aggacgggug ucugugacuc                                                   20


<210>  21415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21415
cagggagggu guggggcagg                                                   20


<210>  21416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21416
cugggaguca cagacacccg                                                   20


<210>  21417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21417
ugcguccccu cugcagggcc                                                   20


<210>  21418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21418
gcagggccuc aggugguccu                                                   20


<210>  21419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21419
ggugguccug gaggaaagca                                                   20


<210>  21420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21420
aggaccaccu gaggcccugc                                                   20


<210>  21421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21421
gccuccccuu gcagggccug                                                   20


<210>  21422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21422
ccuugcaggg ccuggacugc                                                   20


<210>  21423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21423
acucagcccu ccgugcccag                                                   20


<210>  21424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21424
gcccuccgug cccagaccuc                                                   20


<210>  21425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21425
gugcccagac cuccugccug                                                   20


<210>  21426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21426
ugccuggagc ugugggggca                                                   20


<210>  21427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21427
aggcaggagg ucugggcacg                                                   20


<210>  21428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21428
gucggugccc ccacagcucc                                                   20


<210>  21429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21429
caggcucugu cggugccccc                                                   20


<210>  21430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21430
ggggcugcag gggaccuggu                                                   20


<210>  21431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21431
gcccagaccc caucccuucc                                                   20


<210>  21432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21432
cucugcccag accccauccc                                                   20


<210>  21433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21433
cacucugccc agaccccauc                                                   20


<210>  21434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21434
agcccagcac cauccaccaa                                                   20


<210>  21435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21435
agagaggccg caucccagga                                                   20


<210>  21436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21436
ggagggucug caccggcucc                                                   20


<210>  21437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21437
cuggaggguc ugcaccggcu                                                   20


<210>  21438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21438
uugggggcug cugucccggg                                                   20


<210>  21439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21439
ucuuuggggg cugcuguccc                                                   20


<210>  21440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21440
cccgacacuc cucuuugggg                                                   20


<210>  21441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21441
aacagggaca aagacuucuc                                                   20


<210>  21442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21442
ugggacuguc ugaugcagaa                                                   20


<210>  21443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21443
agagggugug cucccccggc                                                   20


<210>  21444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21444
ugaggcuggc aggcccugcc                                                   20


<210>  21445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21445
cccggccggu gagugccuga                                                   20


<210>  21446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21446
ccggccgggg gagcacaccc                                                   20


<210>  21447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21447
ggcacucacc ggccggggga                                                   20


<210>  21448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21448
acucaggcac ucaccggccg                                                   20


<210>  21449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21449
ugucacucca cucaggcacu                                                   20


<210>  21450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21450
cagauugucc caccuggggg                                                   20


<210>  21451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21451
cgagcgucug cuggguuauc                                                   20


<210>  21452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21452
ggagccacca uguucaccua                                                   20


<210>  21453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21453
acugcgcagg auacgggaua                                                   20


<210>  21454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21454
cacgccagcc ccagaaggcu                                                   20


<210>  21455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21455
ggguggaugu ucauuccaag                                                   20


<210>  21456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21456
aggcuuggaa ugaacaucca                                                   20


<210>  21457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21457
cuggccuggg acccauugcu                                                   20


<210>  21458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21458
agcagcccag gguugaaacu                                                   20


<210>  21459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21459
gggcaacccc acaggguguc                                                   20


<210>  21460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21460
ucugaccgac cucugggcaa                                                   20


<210>  21461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21461
gucccauccc cucaucugac                                                   20


<210>  21462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21462
gcucuguccc auccccucau                                                   20


<210>  21463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21463
cgcccaccuc cccacccuga                                                   20


<210>  21464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21464
ccacccugac caggccagcc                                                   20


<210>  21465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21465
ucuccgcuca gaggcccuga                                                   20


<210>  21466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21466
ccgcucagag gcccugaugc                                                   20


<210>  21467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21467
gcucagaggc ccugaugccu                                                   20


<210>  21468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21468
gaggcccuga ugccucuucc                                                   20


<210>  21469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21469
gagcggagag gaggugccag                                                   20


<210>  21470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21470
uccccuggcc ccucauaagc                                                   20


<210>  21471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21471
uaagccuccc uagaugcugc                                                   20


<210>  21472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21472
cuagaugcug cccccuuugc                                                   20


<210>  21473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21473
gcgcuggaga ccaccucccu                                                   20


<210>  21474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21474
agcgcugagc gggaaggcag                                                   20


<210>  21475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21475
cuuguggaug ggcccggcgu                                                   20


<210>  21476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21476
acgccgggcc cauccacaag                                                   20


<210>  21477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21477
cuccacgccg ggcccaucca                                                   20


<210>  21478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21478
agggcugggg ccugcucccu                                                   20


<210>  21479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21479
uccagggcug gggccugcuc                                                   20


<210>  21480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21480
uggugugagg gagagaggaa                                                   20


<210>  21481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21481
caccaggagc gcagggucug                                                   20


<210>  21482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21482
cucacaccag gagcgcaggg                                                   20


<210>  21483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21483
cccucacacc aggagcgcag                                                   20


<210>  21484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21484
cucccucaca ccaggagcgc                                                   20


<210>  21485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21485
uccuugcguu uuucucaauc                                                   20


<210>  21486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21486
uugcguuuuu cucaaucgug                                                   20


<210>  21487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21487
aucgugagca cgucuuucug                                                   20


<210>  21488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21488
cgauugagaa aaacgcaagg                                                   20


<210>  21489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21489
gccacagcgc cuggcauggc                                                   20


<210>  21490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21490
gugugggacu gcagggugcc                                                   20


<210>  21491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21491
augucuccac cgcguccuca                                                   20


<210>  21492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21492
accgcguccu cacugcggaa                                                   20


<210>  21493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21493
cugcggaaug cgugucugcg                                                   20


<210>  21494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21494
cugggcaggg ccccggggga                                                   20


<210>  21495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21495
gggcagggcc ccgggggagg                                                   20


<210>  21496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21496
cccggggccc ugcccagaga                                                   20


<210>  21497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21497
ucccccgggg cccugcccag                                                   20


<210>  21498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21498
cugcuggugg cccugcaugc                                                   20


<210>  21499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21499
cuucuuccuc ccaggugcgg                                                   20


<210>  21500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21500
ucuuccuccc aggugcgggg                                                   20


<210>  21501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21501
caggugcggg ggcugggggu                                                   20


<210>  21502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21502
ccacccccag cccccgcacc                                                   20


<210>  21503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21503
acaggauguc aagaacacuu                                                   20


<210>  21504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21504
ccacaggaug ucaagaacac                                                   20


<210>  21505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21505
agugucuggc cuggggccac                                                   20


<210>  21506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21506
gaaaagccac cgggagggcc                                                   20


<210>  21507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21507
cgguggcuuu ucugagcugg                                                   20


<210>  21508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21508
ggcccucccg guggcuuuuc                                                   20


<210>  21509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21509
aggacucggg cccucccggu                                                   20


<210>  21510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21510
aagacccugc cagcuccagg                                                   20


<210>  21511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21511
gaaacccgag ggaucuggcc                                                   20


<210>  21512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21512
gguuucugag uuucagcuuc                                                   20


<210>  21513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21513
gcccagcagu ccaugucuug                                                   20


<210>  21514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21514
ccuauccuug cucucggugg                                                   20


<210>  21515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21515
cggugggacu gagcccggcc                                                   20


<210>  21516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21516
gugggacuga gcccggccug                                                   20


<210>  21517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21517
gucccaccga gagcaaggau                                                   20


<210>  21518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21518
ugcaggccgg gcucaguccc                                                   20


<210>  21519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21519
gugggguccc uccugcaggc                                                   20


<210>  21520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21520
ugcgccgucu ccgugggguc                                                   20


<210>  21521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21521
cggcuccugc gccgucuccg                                                   20


<210>  21522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21522
cggggcaccu gccagggggc                                                   20


<210>  21523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21523
ggggcucacg gggcaccugc                                                   20


<210>  21524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21524
acagcgccuc cgcuaacgag                                                   20


<210>  21525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21525
gcuaacgagg ggcugggggu                                                   20


<210>  21526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21526
uuagcggagg cgcuguggag                                                   20


<210>  21527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21527
ggaagggccg acccaguguc                                                   20


<210>  21528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21528
gcucaggaag ggccgaccca                                                   20


<210>  21529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21529
ugguggugga uuuccugugc                                                   20


<210>  21530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21530
ugccccaacg gacuggggcu                                                   20


<210>  21531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21531
gggcugaaga ccgggcgugg                                                   20


<210>  21532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21532
ccccauagaa acaucaagaa                                                   20


<210>  21533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21533
ccauagaaac aucaagaaca                                                   20


<210>  21534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21534
gcccccgcgu caggacaggg                                                   20


<210>  21535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21535
gauucccugu ccugacgcgg                                                   20


<210>  21536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21536
cugauucccu guccugacgc                                                   20


<210>  21537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21537
cagcuccaca ugugggagca                                                   20


<210>  21538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21538
gcuccacaug ugggagcagu                                                   20


<210>  21539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21539
acauguggga gcagugaccu                                                   20


<210>  21540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21540
cacaugugga gcugagagcu                                                   20


<210>  21541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21541
uuccccgccu gcguccucgu                                                   20


<210>  21542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21542
ucuacucaca gggcucuuga                                                   20


<210>  21543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21543
cagggcucuu gagggcaaug                                                   20


<210>  21544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21544
ugagggcaau ggagaggugg                                                   20


<210>  21545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21545
agagcccugu gaguagacga                                                   20


<210>  21546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21546
auugcccuca agagcccugu                                                   20


<210>  21547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21547
ccauugcccu caagagcccu                                                   20


<210>  21548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21548
cgcccaccuc uccauugccc                                                   20


<210>  21549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21549
agaugccagg gccaggcccu                                                   20


<210>  21550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence CTCN PAM

<400>  21550
uccugggcug cccuugguga                                                   20


<210>  21551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21551
uuagggcaau guuuuuuucu                                                   20


<210>  21552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21552
ccccaggaag ccgguguaaa                                                   20


<210>  21553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21553
cugccacggg uggguuuugc                                                   20


<210>  21554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21554
aaacugcaug gcuggcucuc                                                   20


<210>  21555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21555
auggaggggc ccccccacuu                                                   20


<210>  21556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21556
ccuacacccc cugccucccu                                                   20


<210>  21557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21557
aaaaauaucc auucacuuuu                                                   20


<210>  21558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21558
uccuccuuca aacacuugac                                                   20


<210>  21559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21559
aguguuugaa ggaggaagac                                                   20


<210>  21560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21560
uuuuucaguu ggauugcaaa                                                   20


<210>  21561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21561
cauuugguga aacgauuacu                                                   20


<210>  21562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21562
ucggauuuua caugaguccc                                                   20


<210>  21563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21563
agugccuucc ugcaggaaag                                                   20


<210>  21564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21564
ccuuuccugc aggaaggcac                                                   20


<210>  21565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21565
ggcaaagucu ccuuuccugc                                                   20


<210>  21566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21566
cgcggacagg aguguaaauc                                                   20


<210>  21567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21567
gcgggacccc agagcuggca                                                   20


<210>  21568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21568
ccuugcucga accucuacag                                                   20


<210>  21569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21569
ugagacccca uuuguaaaac                                                   20


<210>  21570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21570
caagacaagu caccuugcuc                                                   20


<210>  21571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21571
uuugugaacg uuuaaacuau                                                   20


<210>  21572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21572
ucuccuaggu ccugggcauc                                                   20


<210>  21573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21573
ugggcaucca gacaacaaau                                                   20


<210>  21574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21574
ggaugcccag gaccuaggag                                                   20


<210>  21575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21575
ucccauggcc ugugcccccc                                                   20


<210>  21576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21576
gacaugguga accccauugc                                                   20


<210>  21577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21577
gacuggcccc caaaccucuc                                                   20


<210>  21578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21578
gcccuggucc ugacaaccau                                                   20


<210>  21579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21579
ugacaaccau agaggaggca                                                   20


<210>  21580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21580
ggaccagggc ugacugcagc                                                   20


<210>  21581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21581
cccugaggau gaaggaugcg                                                   20


<210>  21582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21582
gggucuguuc ccagcaacca                                                   20


<210>  21583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21583
guucccagca accaaguacc                                                   20


<210>  21584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21584
cagugggggc cugccacccc                                                   20


<210>  21585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21585
cagaggccau cacagcuucc                                                   20


<210>  21586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21586
guguuucuug gagucucaga                                                   20


<210>  21587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21587
ccgccugcuu acaccaccca                                                   20


<210>  21588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21588
auaauggcag aaccaguggg                                                   20


<210>  21589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21589
uugguugagc uguuacugug                                                   20


<210>  21590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21590
uggacagaga ugaucuccuc                                                   20


<210>  21591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21591
aagacucaca guaacagcuc                                                   20


<210>  21592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21592
cagcaucccc accugacacu                                                   20


<210>  21593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21593
gguggggaug cugagaccug                                                   20


<210>  21594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21594
cucccacacc ugugccucag                                                   20


<210>  21595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21595
aaauagcauu ggagcuccag                                                   20


<210>  21596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21596
ugugucuaaa uagcauugga                                                   20


<210>  21597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21597
ucagugguug ccggucaugu                                                   20


<210>  21598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21598
acucaaacaa aaccacaccc                                                   20


<210>  21599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21599
cuuaccagcu cucagaugug                                                   20


<210>  21600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21600
aacaaaauga ccuaaagaca                                                   20


<210>  21601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21601
uuuuguucga ccuuaagagg                                                   20


<210>  21602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21602
uuaggucauu uuguucgacc                                                   20


<210>  21603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21603
ugccccacag gcugaguguc                                                   20


<210>  21604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21604
gcccugccug cugaguccaa                                                   20


<210>  21605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21605
aaauaucaau uacgugaagc                                                   20


<210>  21606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21606
agagcuucac guaauugaua                                                   20


<210>  21607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21607
gaggcagaga gucgagagcu                                                   20


<210>  21608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21608
gguaugguuu cuguuaaaug                                                   20


<210>  21609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21609
ucacucaggg cucuccuucc                                                   20


<210>  21610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21610
gcgcagggag ugaugcucgc                                                   20


<210>  21611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21611
gcagcccagg cucuuaauug                                                   20


<210>  21612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21612
cacacucccc caaccacaaa                                                   20


<210>  21613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21613
cauuuccugc gcuuugcuga                                                   20


<210>  21614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21614
cuuccuaaga ggccagggag                                                   20


<210>  21615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21615
gcacugcacu cccgcugacc                                                   20


<210>  21616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21616
gcgggagugc agugcggacg                                                   20


<210>  21617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21617
ugccaccccu cccagaaagc                                                   20


<210>  21618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21618
cucucagcug ugugugguuc                                                   20


<210>  21619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21619
gagcaggcgu ggcuggcccu                                                   20


<210>  21620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21620
ucccaggacu uccugagccc                                                   20


<210>  21621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21621
ugggaggacg cuuggcagug                                                   20


<210>  21622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21622
uuggccuggc acguuucucu                                                   20


<210>  21623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21623
cuggaacagg gucugugcuu                                                   20


<210>  21624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21624
gugcuuggca uggggcaugg                                                   20


<210>  21625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21625
augccccaug ccaagcacag                                                   20


<210>  21626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21626
cuacagcacu gcguccaugc                                                   20


<210>  21627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21627
ccugggaaac gaauggcugu                                                   20


<210>  21628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21628
aggcacaugc cagugacugc                                                   20


<210>  21629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21629
cuggcaugug ccuugacuuc                                                   20


<210>  21630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21630
accaagaccc cucccacagc                                                   20


<210>  21631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21631
ugguggacac uggggccugg                                                   20


<210>  21632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21632
ucgccccuca cccucagcca                                                   20


<210>  21633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21633
uccuuuuggg gcuccccacu                                                   20


<210>  21634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21634
cgaagugcag agaugaggcg                                                   20


<210>  21635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21635
ggauauaucu guuugguccc                                                   20


<210>  21636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21636
ugggcccuug aagagagcug                                                   20


<210>  21637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21637
ccugaggguu uucgggguuc                                                   20


<210>  21638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21638
cauacucagu acugcucagu                                                   20


<210>  21639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21639
uggcagguuc ccacaaaaca                                                   20


<210>  21640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21640
gccugggugc caaccccacu                                                   20


<210>  21641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21641
ucuuucauaa agcacacaca                                                   20


<210>  21642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21642
cucaggcuuc ucuuggcaaa                                                   20


<210>  21643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21643
ucgcuaaucu gggccuggaa                                                   20


<210>  21644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21644
ccccgcuuug uaggagaaca                                                   20


<210>  21645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21645
gggggugcag acaagcgagc                                                   20


<210>  21646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21646
gcacccccag accguuuuca                                                   20


<210>  21647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21647
auuccuccuc aaagauggaa                                                   20


<210>  21648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21648
agguaagugu ccaggucccu                                                   20


<210>  21649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21649
aggucccucu cccccaugcc                                                   20


<210>  21650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21650
cucuccccca ugccgggaau                                                   20


<210>  21651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21651
cuaggaggug agaauucccg                                                   20


<210>  21652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21652
aucaauagaa agucauaacc                                                   20


<210>  21653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21653
uaaccaagca agaaacacag                                                   20


<210>  21654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21654
cagugcugug uuucuugcuu                                                   20


<210>  21655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21655
ucaucugaaa caaaagucuc                                                   20


<210>  21656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21656
uuucaagaga guuuaugcuu                                                   20


<210>  21657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21657
ugcuuuauug auguugguga                                                   20


<210>  21658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21658
gcuuguccug cuuuauugau                                                   20


<210>  21659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21659
cuuccuggga guguucaaag                                                   20


<210>  21660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21660
ggauaauacu uacaagaucu                                                   20


<210>  21661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21661
uuuaaacacc aauaugauuu                                                   20


<210>  21662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21662
uuuuaauguu aaacuuuugu                                                   20


<210>  21663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21663
cccaggcuug agugcagugg                                                   20


<210>  21664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21664
ugcucugucg cccaggcuug                                                   20


<210>  21665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21665
caaaaaaaaa aaaaaagaaa                                                   20


<210>  21666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21666
cacucuguug cccaggcuag                                                   20


<210>  21667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21667
cagcuacuca ggaggauaau                                                   20


<210>  21668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21668
ggugguggug gugauuuuuu                                                   20


<210>  21669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21669
cuacaaaaau auuaaaaaau                                                   20


<210>  21670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21670
cacugugaug cccaggcugg                                                   20


<210>  21671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21671
ugaacuccug ggcucaagca                                                   20


<210>  21672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21672
cccaccucag ccucccaaag                                                   20


<210>  21673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21673
ucaaaacaaa acaaagcugg                                                   20


<210>  21674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21674
uacucccaau uaaccugggg                                                   20


<210>  21675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21675
gguuaaccuu uauaagaucu                                                   20


<210>  21676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21676
uugggagacc cggggaccag                                                   20


<210>  21677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21677
cccaaugacu gcagaucuua                                                   20


<210>  21678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21678
ccgggucucc caaugacugc                                                   20


<210>  21679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21679
cccuuuuacc uaucagcucu                                                   20


<210>  21680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21680
uagguucugg ucucucagau                                                   20


<210>  21681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21681
cucagaucua cuggucaguu                                                   20


<210>  21682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21682
guuugaucag uggauuuauc                                                   20


<210>  21683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21683
ucaguguugu cagccacaaa                                                   20


<210>  21684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21684
gccacaaaau aacugcuuug                                                   20


<210>  21685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21685
aaagcaguua uuuuguggcu                                                   20


<210>  21686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21686
aagugccagu uuaugaauuu                                                   20


<210>  21687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21687
caguguaaau ucauaaacug                                                   20


<210>  21688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21688
cugaggauaa ggggcaucug                                                   20


<210>  21689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21689
cccugaacac acgauccauc                                                   20


<210>  21690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21690
uggcggaacu gguaaggaag                                                   20


<210>  21691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21691
aauaguuuga gugcacugcu                                                   20


<210>  21692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21692
gaacaucagg gaacccucua                                                   20


<210>  21693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21693
cagcuacugg gaaggcugag                                                   20


<210>  21694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21694
cacuauguug cccaggcuug                                                   20


<210>  21695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21695
ucuucaaaaa agaaaaaaag                                                   20


<210>  21696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21696
uuuuuucuuu uuugaagaag                                                   20


<210>  21697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21697
cucacugcau cuuaccgcau                                                   20


<210>  21698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21698
cgagguguga gugucuuuga                                                   20


<210>  21699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21699
uugauuuuua cuggauaaau                                                   20


<210>  21700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21700
ggcauuuauc caguaaaaau                                                   20


<210>  21701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21701
cuacuaaaaa uacaaaaaau                                                   20


<210>  21702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21702
cgaucuccug accuugugau                                                   20


<210>  21703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21703
ggagaucgag accacccggc                                                   20


<210>  21704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21704
cucacgcuug uaaucccagc                                                   20


<210>  21705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21705
cagccucccg aguagcuggg                                                   20


<210>  21706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21706
ggcuggucuu gaacgccuga                                                   20


<210>  21707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21707
ugaacgccug aucucaggug                                                   20


<210>  21708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21708
gccuuggccu cccaaagugc                                                   20


<210>  21709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21709
uuuuuuuguu guuguugaug                                                   20


<210>  21710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21710
uagcugcuug ggaggcugag                                                   20


<210>  21711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21711
cacucugcca cccaggcugg                                                   20


<210>  21712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21712
ugaacuccca accucaagug                                                   20


<210>  21713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21713
uuuuaguaga gaugggguuu                                                   20


<210>  21714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21714
cugcaaccuc ucccuccugg                                                   20


<210>  21715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21715
caaaaaaaaa aauauauaua                                                   20


<210>  21716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21716
ugaaaauguu ucccuuuacc                                                   20


<210>  21717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21717
ugaggauauu auccaucauc                                                   20


<210>  21718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21718
auaauuaaag aauugauuuu                                                   20


<210>  21719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21719
guguaucaua ccuugauucu                                                   20


<210>  21720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21720
acuuuucuau ccuugagcgg                                                   20


<210>  21721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21721
ugcucuguug cccaggcugg                                                   20


<210>  21722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21722
cagccacuca ggaggcugag                                                   20


<210>  21723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21723
cuacaaaaaa uuuaaaaaua                                                   20


<210>  21724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21724
cccucuguug cucaggcggu                                                   20


<210>  21725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21725
ugaacuccug ggcucaagca                                                   20


<210>  21726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21726
gcugccaugc ucagccuagu                                                   20


<210>  21727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21727
guuuguguug cuauaaggaa                                                   20


<210>  21728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21728
ucuucaccuu gugccguaag                                                   20


<210>  21729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21729
agaugacaug augagagaaa                                                   20


<210>  21730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21730
ucuggacaca cuggguccuc                                                   20


<210>  21731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21731
uuccagcacu gagugaguuc                                                   20


<210>  21732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21732
cucaugaaug gcuuggugcu                                                   20


<210>  21733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21733
ugagggcagg ucccucauga                                                   20


<210>  21734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21734
cagcugcuca ggagucugag                                                   20


<210>  21735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21735
gaggugaaag gaucgcuuga                                                   20


<210>  21736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21736
cgaacuucug ggcucaagcg                                                   20


<210>  21737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21737
ccaggcuagu cucgaacuuc                                                   20


<210>  21738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21738
cugcuaaaaa uacaaaaauu                                                   20


<210>  21739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21739
gccaaguagc uggaacuaca                                                   20


<210>  21740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21740
agccuaggca acagagugac                                                   20


<210>  21741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21741
cucuguugcc uaggcuggac                                                   20


<210>  21742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21742
caaaauaugu aaauaaaaga                                                   20


<210>  21743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21743
accccagcuc uuucuuuuca                                                   20


<210>  21744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21744
cccacucuga agaaacacaa                                                   20


<210>  21745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21745
ucuucucaua ucaucacuuu                                                   20


<210>  21746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21746
ucaaguggcg acaggguggg                                                   20


<210>  21747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21747
ccacuugagg accacugauu                                                   20


<210>  21748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21748
gguugugaag agcuaguugg                                                   20


<210>  21749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21749
uccaacuagc ucuucacaac                                                   20


<210>  21750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21750
gcggaugugu gggagcugug                                                   20


<210>  21751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21751
gugaauaccc aucuuccuuu                                                   20


<210>  21752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21752
augucccugu ucuucccucc                                                   20


<210>  21753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21753
cuguucuucc cuccugggca                                                   20


<210>  21754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21754
augcggagca gggugcccag                                                   20


<210>  21755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21755
cugagccuaa ugauggaagu                                                   20


<210>  21756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21756
ugccgugaaa guucuggugc                                                   20


<210>  21757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21757
ucuccucauc uuuugacuua                                                   20


<210>  21758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21758
ccucaucuuu ugacuuacau                                                   20


<210>  21759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21759
aaagaugagg agacgacuua                                                   20


<210>  21760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21760
auguaaguca aaagaugagg                                                   20


<210>  21761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21761
ucagccuggu gacuuagcuu                                                   20


<210>  21762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21762
ccaggcugau gacuaaaaau                                                   20


<210>  21763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21763
cuggcuagcc ucugguuugg                                                   20


<210>  21764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21764
uugggucaga ugccucccug                                                   20


<210>  21765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21765
gaugccuccc ugcugccagg                                                   20


<210>  21766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21766
gaugaugggg accuccccau                                                   20


<210>  21767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21767
ccaucaucag acccucaucc                                                   20


<210>  21768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21768
cccacaccuc ugcugauggg                                                   20


<210>  21769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21769
ggugugcaaa uggcuacuuu                                                   20


<210>  21770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21770
cuuaauuuug agaugcuacc                                                   20


<210>  21771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21771
cugaauaaaa gccacuuuca                                                   20


<210>  21772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21772
uuucugggua uugcuguaaa                                                   20


<210>  21773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21773
uuacagcaau acccagaaau                                                   20


<210>  21774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21774
uuuugcauaa gguauuaaca                                                   20


<210>  21775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21775
ugaaaaauca caguaaccag                                                   20


<210>  21776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21776
aauaaaaagu ugguaucaaa                                                   20


<210>  21777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21777
gcugcuauua auaaauucaa                                                   20


<210>  21778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21778
cuacauucag gcuccauaca                                                   20


<210>  21779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21779
caugacagag cagggauaug                                                   20


<210>  21780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21780
ugggacagca caaauaucua                                                   20


<210>  21781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21781
ggaugccagg gcaaguuuca                                                   20


<210>  21782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21782
auuaaauaau auaauuacua                                                   20


<210>  21783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21783
uaaggaaaac uguuauauua                                                   20


<210>  21784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21784
cuguugaauu uuauugaguu                                                   20


<210>  21785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21785
cuaaaauacc ugugcccuuu                                                   20


<210>  21786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21786
agggaacacu guuaugugua                                                   20


<210>  21787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21787
ggaauuugag aucagccuga                                                   20


<210>  21788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21788
ggcugaucuc aaauuccuga                                                   20


<210>  21789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21789
gucaggcuga ucucaaauuc                                                   20


<210>  21790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21790
cgcucuguug cccaggcugg                                                   20


<210>  21791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21791
caaaaaaaaa aaaaaagaaa                                                   20


<210>  21792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21792
ggagaucgag accauccugg                                                   20


<210>  21793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21793
cgaucuccug accucgugau                                                   20


<210>  21794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21794
cuacuaacaa cgccugucug                                                   20


<210>  21795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21795
gggcguggug gcuccugccu                                                   20


<210>  21796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21796
cagcuacuug ggaggcugag                                                   20


<210>  21797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21797
ccaggcugga augcaguggc                                                   20


<210>  21798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21798
cgcucuguca ccaggcugga                                                   20


<210>  21799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21799
ugccuaccuc aaucacaauu                                                   20


<210>  21800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21800
aaaucaauaa uacacacuuu                                                   20


<210>  21801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21801
aguccaaauc aauaauacac                                                   20


<210>  21802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21802
auaaugcacc cagcaaccag                                                   20


<210>  21803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21803
aaugggaaga uggacaugug                                                   20


<210>  21804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21804
aucuucccau uagacacuca                                                   20


<210>  21805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21805
auaggaagug uagaaguugg                                                   20


<210>  21806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21806
ggagaucgag accauccugg                                                   20


<210>  21807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21807
cgaucuccug accucgugau                                                   20


<210>  21808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21808
cuacuaaaaa uacaaaaaau                                                   20


<210>  21809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21809
cagagcaaga cucccucuca                                                   20


<210>  21810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21810
ugcucuguga cccaggcugg                                                   20


<210>  21811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21811
cacgcagcua auuacuacaa                                                   20


<210>  21812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21812
uguaaaggaa aggcggggag                                                   20


<210>  21813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21813
guguguucuu gcaaaaucac                                                   20


<210>  21814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21814
uuagcaaagg aucaagcagg                                                   20


<210>  21815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21815
uagguacagu gugagggggu                                                   20


<210>  21816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21816
aaacccccuc acacuguacc                                                   20


<210>  21817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21817
gcuccccaca ugcccuccau                                                   20


<210>  21818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21818
gcaggaggug gcagcgucac                                                   20


<210>  21819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21819
ccagcacggg gccuuuguug                                                   20


<210>  21820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21820
ccugcauuag ccuucauagg                                                   20


<210>  21821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21821
aaucuggguu gugcugcugu                                                   20


<210>  21822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21822
ucuuagggua aaaacacagu                                                   20


<210>  21823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21823
uuuaugauac acacacaccu                                                   20


<210>  21824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21824
cuggguggua gaaaaucagu                                                   20


<210>  21825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21825
guauucuccu augcaaaaau                                                   20


<210>  21826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21826
cuuacaugga uauauauaca                                                   20


<210>  21827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21827
acuaaaaaua caaaaaauua                                                   20


<210>  21828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21828
ugaacuccug accucuugau                                                   20


<210>  21829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21829
ggaguucaag accagccugg                                                   20


<210>  21830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21830
caaacaguga aacaaaggac                                                   20


<210>  21831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21831
uuuguuucac uguuugagac                                                   20


<210>  21832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21832
ugccugccug ugggccaaug                                                   20


<210>  21833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21833
gaaggcuagg acuuggagag                                                   20


<210>  21834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21834
uagccuucag acucucucca                                                   20


<210>  21835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21835
ggguagcucu ccaaguccua                                                   20


<210>  21836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21836
gaggaucucc uugauugagg                                                   20


<210>  21837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21837
caacucagcc uccucaauca                                                   20


<210>  21838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21838
cgcuccucac uuccagggug                                                   20


<210>  21839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21839
ugcagguugu aagauuuucc                                                   20


<210>  21840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21840
uuucagggcu uguaggcucu                                                   20


<210>  21841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21841
gguccuuuca gggcuuguag                                                   20


<210>  21842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21842
ugggccauag gaggguuguu                                                   20


<210>  21843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21843
ggugcugggu auuuuuucau                                                   20


<210>  21844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21844
cuagcucuuc uccuccucuc                                                   20


<210>  21845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21845
aagcugcugc ugucuggcuc                                                   20


<210>  21846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21846
ggcuccugaa cugcagauag                                                   20


<210>  21847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21847
uuucuuccca uugucccauc                                                   20


<210>  21848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21848
caucccaucu cucucugcac                                                   20


<210>  21849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21849
cuccuugacu ucaguggccc                                                   20


<210>  21850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21850
aggagugacu cugaggcugc                                                   20


<210>  21851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21851
gccccaugcc agccacuggg                                                   20


<210>  21852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21852
gcuucggggg ucuccucaag                                                   20


<210>  21853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21853
ccucaaggag gcccucacug                                                   20


<210>  21854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21854
accggguuaa aggguacaga                                                   20


<210>  21855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21855
uauuuauugc cuuugucuuu                                                   20


<210>  21856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21856
uugacaguuu ucuucaccau                                                   20


<210>  21857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21857
aagacaaagg caauaaauaa                                                   20


<210>  21858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21858
aggcacugag ggcacaaugg                                                   20


<210>  21859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21859
cugagcaugu gaugggcuca                                                   20


<210>  21860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21860
uccaggauuu acugagccca                                                   20


<210>  21861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21861
uuucuggcuc uuaacauuau                                                   20


<210>  21862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21862
ccaagccuaa aaucauaaug                                                   20


<210>  21863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21863
gauggguaug gcuguucugc                                                   20


<210>  21864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21864
uagaaaacag cucccaucac                                                   20


<210>  21865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21865
ucauuuaggc uuuugggauu                                                   20


<210>  21866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21866
uuuaggcuuu ugggauuugu                                                   20


<210>  21867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21867
ggcguucucu aggacacugu                                                   20


<210>  21868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21868
uagagaacgc cagacuacuc                                                   20


<210>  21869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21869
uaccucccca caguguccua                                                   20


<210>  21870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21870
gccccugugc cccaaacauu                                                   20


<210>  21871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21871
gcaguuuuga ucacugguuc                                                   20


<210>  21872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21872
ugcugguauu gucauucauu                                                   20


<210>  21873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21873
uucauucuuu caaucacuaa                                                   20


<210>  21874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21874
gcaggaaguc uuaagaaugg                                                   20


<210>  21875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21875
uaagaaugga gccugggguc                                                   20


<210>  21876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21876
aaaugagagc ccucaguggc                                                   20


<210>  21877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21877
uuuugaauac cggugguggg                                                   20


<210>  21878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21878
ccccauccca ccaccgguau                                                   20


<210>  21879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21879
agccggccuu ggagaagcuu                                                   20


<210>  21880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21880
ccaucuccac ccagaagcuu                                                   20


<210>  21881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21881
gcugggucca cucucuuccc                                                   20


<210>  21882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21882
acucucuucc caccuggcau                                                   20


<210>  21883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21883
ugcagcaagg acacccuaca                                                   20


<210>  21884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21884
uugcugcaag acaugccagg                                                   20


<210>  21885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21885
cuccugccgu guaggguguc                                                   20


<210>  21886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21886
uucacacagg gcugccucug                                                   20


<210>  21887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21887
uaggauuggg uugauacggg                                                   20


<210>  21888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21888
cccccgacac acacacacuu                                                   20


<210>  21889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21889
ggggagacac aggauuuuua                                                   20


<210>  21890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21890
ugggacuuua accccauuuc                                                   20


<210>  21891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21891
caagaccagc aagugugugu                                                   20


<210>  21892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21892
cacacaacug gaaauggggu                                                   20


<210>  21893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21893
caaaaaaaaa aaaaaaaaaa                                                   20


<210>  21894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21894
ugcucuauug cccaggcugg                                                   20


<210>  21895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21895
gccuccugag uagcugggau                                                   20


<210>  21896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21896
aaaaaaaaaa agaaagaaaa                                                   20


<210>  21897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21897
ugcccucuca cccaggcuag                                                   20


<210>  21898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21898
aggcuguagu gagcugugau                                                   20


<210>  21899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21899
cagcuacuag ggaggcugag                                                   20


<210>  21900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21900
ugcuauguua cugaggcugg                                                   20


<210>  21901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21901
caaaccucug agcucaaaug                                                   20


<210>  21902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21902
uacaaugugg ggcaagggga                                                   20


<210>  21903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21903
gggccuugga ugugcagcug                                                   20


<210>  21904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21904
aaauuccaga uucaagauaa                                                   20


<210>  21905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21905
gcuguccaaa uuccagauuc                                                   20


<210>  21906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21906
gcagaugcaa accaucuuug                                                   20


<210>  21907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21907
gaaacuacua uucuagaggc                                                   20


<210>  21908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21908
gaaaauugag gcugacaguu                                                   20


<210>  21909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21909
gccucaauuu ucagacuguu                                                   20


<210>  21910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21910
ugauccuggg cggccccacc                                                   20


<210>  21911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21911
acccccccag ccccgugguc                                                   20


<210>  21912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21912
cugggcacug gggugucacu                                                   20


<210>  21913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21913
cugggaggga cacgcaggag                                                   20


<210>  21914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21914
cucccaguga caccccagug                                                   20


<210>  21915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21915
cuccugcgug ucccucccag                                                   20


<210>  21916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21916
gucccuccug cgugucccuc                                                   20


<210>  21917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21917
acaguaggug cuuaguucuc                                                   20


<210>  21918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21918
aggcccgcga caacgccagu                                                   20


<210>  21919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21919
cgggccuaga cgccgggucc                                                   20


<210>  21920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21920
ucgcccccca ggggccucgu                                                   20


<210>  21921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21921
cggggccgcg gaggccacgu                                                   20


<210>  21922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21922
gagcugggcg uggggcgggg                                                   20


<210>  21923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21923
cgcaauccug gagguccgag                                                   20


<210>  21924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21924
gcccuccucc uggccccgcc                                                   20


<210>  21925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21925
cgcccgcgcc cgcccagucc                                                   20


<210>  21926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21926
cgcgggcggg agcgccuggc                                                   20


<210>  21927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21927
agccgccgcc ucgacccagg                                                   20


<210>  21928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21928
aggcggcggc uugacucggc                                                   20


<210>  21929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21929
cggcgggucu cgggggucuc                                                   20


<210>  21930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21930
cgggggucuc gcgggggggc                                                   20


<210>  21931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21931
cgcggggggg cggucuccgc                                                   20


<210>  21932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21932
ccgcgucugg aaggggcucg                                                   20


<210>  21933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21933
ggaaggggcu cggcgggccu                                                   20


<210>  21934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21934
gggggcucuc ggcgggucuc                                                   20


<210>  21935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21935
cgggggucuc gggggagucu                                                   20


<210>  21936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21936
cgggggaguc ucgggguccc                                                   20


<210>  21937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21937
cggggucccg acaggucucg                                                   20


<210>  21938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21938
cgacaggucu cggcgggucu                                                   20


<210>  21939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21939
ggaccccgag acucccccga                                                   20


<210>  21940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21940
cggcgggucu cgggggucuc                                                   20


<210>  21941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21941
cgggggucuc gggggagucu                                                   20


<210>  21942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21942
cgggggaguc uccggggagu                                                   20


<210>  21943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21943
ccggggaguc ucaggggucc                                                   20


<210>  21944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21944
cagggguccc ggcaggucuu                                                   20


<210>  21945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21945
cggcaggucu uggcaggucu                                                   20


<210>  21946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21946
uggcaggucu cgggggaguc                                                   20


<210>  21947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21947
cgggggaguc ucaggguccc                                                   20


<210>  21948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21948
cagggucccg gcagguaugg                                                   20


<210>  21949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21949
cggcagguau gggcgggugu                                                   20


<210>  21950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21950
ggggucucgg gugcgcagca                                                   20


<210>  21951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21951
cgggugcgca gcagccuccc                                                   20


<210>  21952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21952
uugccaaagg acgcacgggg                                                   20


<210>  21953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21953
uuuggcaagg acacggaggc                                                   20


<210>  21954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21954
cuugccgggg gcucaggggu                                                   20


<210>  21955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21955
caccgccucc caccccugag                                                   20


<210>  21956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21956
guuucgcacc ccucgcgccc                                                   20


<210>  21957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21957
cguaaagggg ccccgccgcg                                                   20


<210>  21958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21958
uguggggagg gucgcguaaa                                                   20


<210>  21959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21959
cucacacuuc agugugaauc                                                   20


<210>  21960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21960
gagacucuca ugggcaacag                                                   20


<210>  21961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21961
cagacgcccg gcuaucaguc                                                   20


<210>  21962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21962
cucugccacc ccugagauuc                                                   20


<210>  21963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21963
ccgcccccua acuccuccag                                                   20


<210>  21964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21964
acagaugagc aaacugaggc                                                   20


<210>  21965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21965
ccagugucaa cagaugagca                                                   20


<210>  21966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21966
aguggccaca cuuaaguccu                                                   20


<210>  21967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21967
uucgaauugg cuguggccag                                                   20


<210>  21968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21968
accccagcag cccacacgga                                                   20


<210>  21969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21969
uccaggcagg cuguccaccc                                                   20


<210>  21970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21970
ccugcaaggc cacacacaug                                                   20


<210>  21971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21971
gcccugcacc aacuccauga                                                   20


<210>  21972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21972
aggcucaugg aguuggugca                                                   20


<210>  21973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21973
cacagggccu gagccaguga                                                   20


<210>  21974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21974
acugucuccu cuacguagac                                                   20


<210>  21975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21975
ccucuacgua gacaccgucg                                                   20


<210>  21976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21976
acguagagga gacaguggac                                                   20


<210>  21977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21977
aagggcccuc uuggagccca                                                   20


<210>  21978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21978
ugccaggagu ggagugccug                                                   20


<210>  21979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21979
caggccuccu guccugccag                                                   20


<210>  21980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21980
auccccucuc ccugccaccc                                                   20


<210>  21981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21981
uccuucugcc ugcccccucc                                                   20


<210>  21982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21982
aggaacugcc agccagggcc                                                   20


<210>  21983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21983
gcaccccucu caccagaugg                                                   20


<210>  21984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21984
ccugucagca ccccucucac                                                   20


<210>  21985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21985
ccaggccucc aggaucaugg                                                   20


<210>  21986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21986
gccucuucag gccagccucc                                                   20


<210>  21987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21987
ucccucuguc ugccucuuca                                                   20


<210>  21988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21988
augugggcag aaagggccaa                                                   20


<210>  21989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21989
gcuggagcuc cccacccccc                                                   20


<210>  21990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21990
gugggccugc uugugugcgu                                                   20


<210>  21991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21991
aggggcccag agagacgaga                                                   20


<210>  21992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21992
cucugggccc cuggacuucc                                                   20


<210>  21993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21993
uggaugagaa aacggagggg                                                   20


<210>  21994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21994
guagggggga uggugguggu                                                   20


<210>  21995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21995
ccaccaccac cauccccccu                                                   20


<210>  21996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21996
cugaauacca agcacauguc                                                   20


<210>  21997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21997
cugagggugc ucucccuggu                                                   20


<210>  21998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21998
ucagggccgc uguauguccu                                                   20


<210>  21999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  21999
uguuuugggu gggggcaggg                                                   20


<210>  22000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22000
cugcccccac ccaaaacagg                                                   20


<210>  22001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22001
aaugugggca ggaaccuggg                                                   20


<210>  22002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22002
aucaggagug gccaguguug                                                   20


<210>  22003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22003
uccugcguuc uguccucaaa                                                   20


<210>  22004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22004
ucaaaagcuc ccuugugggg                                                   20


<210>  22005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22005
ccacaaggga gcuuuugagg                                                   20


<210>  22006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22006
gugacuaugu guggcaggcu                                                   20


<210>  22007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22007
cugaccuggg guguccccac                                                   20


<210>  22008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22008
ucucuugacc ucaugaucug                                                   20


<210>  22009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22009
agagaggaca gagagugagg                                                   20


<210>  22010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22010
uuuccccgcc agccugcccu                                                   20


<210>  22011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22011
uaccccagac gcaguggagc                                                   20


<210>  22012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22012
gggguaggac agcucucacc                                                   20


<210>  22013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22013
ggaggaggga ucugagccgg                                                   20


<210>  22014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22014
guaccugcau ggcugcccgc                                                   20


<210>  22015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22015
gucuguaccu gcauggcugc                                                   20


<210>  22016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22016
cccacccucc cuaccgcccg                                                   20


<210>  22017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22017
aacuggucuc ccacccuccc                                                   20


<210>  22018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22018
gcacggcccc uucuccuugc                                                   20


<210>  22019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22019
ggacaccgag gggcuggaga                                                   20


<210>  22020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22020
agacagggcc accagaagaa                                                   20


<210>  22021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22021
ccagccccuc gguguccaga                                                   20


<210>  22022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22022
cacguguggg cugccuaagu                                                   20


<210>  22023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22023
cagagggggu gguagggagc                                                   20


<210>  22024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22024
agugccccag ggaagggggc                                                   20


<210>  22025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22025
acccucccgu gcacaggcca                                                   20


<210>  22026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22026
cuugcucuug gcaccauccu                                                   20


<210>  22027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22027
ccuggcccgu ggcugagggc                                                   20


<210>  22028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22028
ggaagugcaa uucgccuaca                                                   20


<210>  22029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22029
ucccguuuug cagaucagga                                                   20


<210>  22030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22030
cuggcucugg accacgcugc                                                   20


<210>  22031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22031
agagccaggg acuucuguca                                                   20


<210>  22032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22032
ggggcccggc acggaaccca                                                   20


<210>  22033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22033
cccuugaagg augaguguag                                                   20


<210>  22034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22034
ccacccgccc cgaaccuggg                                                   20


<210>  22035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22035
gacaggaguu cgagguggug                                                   20


<210>  22036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22036
gacccagguc uccacccgcc                                                   20


<210>  22037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22037
ggcccugcuu gguuucccgg                                                   20


<210>  22038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22038
ccucagggcg uuggggccag                                                   20


<210>  22039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22039
caucuggucc aucuuuguca                                                   20


<210>  22040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22040
aucuuuguca gcuggccucu                                                   20


<210>  22041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22041
gcuggccucu gggaagaaug                                                   20


<210>  22042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22042
gcucaagccu gcagagggag                                                   20


<210>  22043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22043
gccaggcugg caggcaacag                                                   20


<210>  22044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22044
gagggcuuca gcguccuccu                                                   20


<210>  22045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22045
uccuugugaa auggggugaa                                                   20


<210>  22046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22046
aacucauggg aggccagauc                                                   20


<210>  22047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22047
agggcaggga ggcccuagcu                                                   20


<210>  22048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22048
ugggucccca ugcccugcag                                                   20


<210>  22049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22049
ccaugcccug cagcccuguc                                                   20


<210>  22050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22050
acuguccuga gcuaggcaua                                                   20


<210>  22051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22051
ugagcuaggc auaggggugg                                                   20


<210>  22052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22052
aggggcagcc agcagcaagg                                                   20


<210>  22053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22053
uucugggagc cuggaaugcu                                                   20


<210>  22054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22054
uuggcuuuuu cucagccuug                                                   20


<210>  22055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22055
ggggcagugg ugcgccuuua                                                   20


<210>  22056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22056
accacugccc cagaggcaga                                                   20


<210>  22057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22057
gcucuugcag ugcaugccua                                                   20


<210>  22058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22058
gagggcagga ccgcuggcag                                                   20


<210>  22059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22059
ugcccucuga ccuguggccu                                                   20


<210>  22060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22060
ucagcugaaa uugcuucuaa                                                   20


<210>  22061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22061
guccugcuug gugcucaggg                                                   20


<210>  22062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22062
ugcuuggugc ucaggguacc                                                   20


<210>  22063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22063
auggccacca ugcauguuga                                                   20


<210>  22064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22064
acaugcaugg uggccauaga                                                   20


<210>  22065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22065
ccauggaugg gucaacaugc                                                   20


<210>  22066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22066
gccugccccu ccugcuuggg                                                   20


<210>  22067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22067
gggucgcguc ugagagccca                                                   20


<210>  22068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22068
cgucugagag cccaugcccu                                                   20


<210>  22069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22069
gagagcccau gcccuggugg                                                   20


<210>  22070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22070
cagaggaagg gugaggggag                                                   20


<210>  22071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22071
cuccccccac cuguguuuaa                                                   20


<210>  22072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22072
gccuggcagc ugccgcccag                                                   20


<210>  22073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22073
gauauuaucu gauuggaaac                                                   20


<210>  22074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22074
cccacgaaac ucuucagguu                                                   20


<210>  22075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22075
cagcgcagcc cgcaggggga                                                   20


<210>  22076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22076
cugcugccgg guggcaggca                                                   20


<210>  22077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22077
cgguggcccu ggcagcggua                                                   20


<210>  22078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22078
ucccuaucua ccgcugccag                                                   20


<210>  22079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22079
guguccccug uccucucccu                                                   20


<210>  22080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22080
ccuguccucu cccugaacga                                                   20


<210>  22081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22081
ucucccugaa cgaaagugcu                                                   20


<210>  22082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22082
caaagagcug gcaccugagg                                                   20


<210>  22083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22083
aagcaaaagg ccggauuucu                                                   20


<210>  22084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22084
ccaugcaggg cuguguaccc                                                   20


<210>  22085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22085
gggaggggcg uuuccgagag                                                   20


<210>  22086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22086
gcugauggcu gggcagauag                                                   20


<210>  22087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22087
gcagagugag uuugaccagg                                                   20


<210>  22088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22088
aacucacucu gcugaccacu                                                   20


<210>  22089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22089
ucuuccccuc ugcccugguc                                                   20


<210>  22090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22090
cuucccccag cucgggggau                                                   20


<210>  22091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22091
cagccuggga acgccugagg                                                   20


<210>  22092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22092
cacggccugg ccugguggag                                                   20


<210>  22093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22093
cugcccugcc cagagaaggc                                                   20


<210>  22094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22094
ggucaucgag gccuccgggc                                                   20


<210>  22095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22095
ucgaggccuc cgggcugauu                                                   20


<210>  22096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22096
uaaucagccc ggaggccucg                                                   20


<210>  22097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22097
ugaggcaggg cggguacggg                                                   20


<210>  22098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22098
ccacaggugg cuccuuccuc                                                   20


<210>  22099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22099
cgccugggag cagcuccucc                                                   20


<210>  22100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22100
cgaggggaag gcauuucaga                                                   20


<210>  22101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22101
cggugagggu cccgagggga                                                   20


<210>  22102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22102
agucgcggug agggucccga                                                   20


<210>  22103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22103
gaagcugagc gaaguccagu                                                   20


<210>  22104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22104
ugggugcugg cuucaggaag                                                   20


<210>  22105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22105
cauccucaag aaaaugggaa                                                   20


<210>  22106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22106
ggguggcugu gccugccucu                                                   20


<210>  22107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22107
uuucucaauc uucuuccuuc                                                   20


<210>  22108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22108
ccuugaugcc agccggcagg                                                   20


<210>  22109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22109
ugagaagcag gggggaccca                                                   20


<210>  22110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22110
ccccugcuuc ucaggacacc                                                   20


<210>  22111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22111
caaguggguc cccccugcuu                                                   20


<210>  22112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22112
ucgagggggc cuggguccca                                                   20


<210>  22113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22113
uggcccuucc aguacgaagc                                                   20


<210>  22114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22114
uucacacagc cugagcccuc                                                   20


<210>  22115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22115
ggagaccacu gccgaacaua                                                   20


<210>  22116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22116
ccagacccca gaguaagcuu                                                   20


<210>  22117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22117
ucuuguggcc acugcuugga                                                   20


<210>  22118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22118
ggggaaaggg ugggggcugc                                                   20


<210>  22119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22119
guggcagccc ccacccuuuc                                                   20


<210>  22120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22120
aggcugcaga aggcugggug                                                   20


<210>  22121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22121
ccuccuccac ucccacccag                                                   20


<210>  22122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22122
cgucaccucc uccacuccca                                                   20


<210>  22123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22123
gugaccccug cacaggggcu                                                   20


<210>  22124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22124
ccgaccccau ccuggucacg                                                   20


<210>  22125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22125
gcugcucccu ccccuuucau                                                   20


<210>  22126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22126
caccagggcc aaugccaccc                                                   20


<210>  22127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22127
gucccaccag ggccaaugcc                                                   20


<210>  22128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22128
ccggcucagu cucccuccuc                                                   20


<210>  22129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22129
cccuccuccu uggcuggcuu                                                   20


<210>  22130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22130
gccagaaaag ccagccaagg                                                   20


<210>  22131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22131
agagcugccu cccuggggag                                                   20


<210>  22132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22132
cuccugaggc ugugucccca                                                   20


<210>  22133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22133
ccagaguguc caccgggcug                                                   20


<210>  22134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22134
accgggcugu gccaccuccc                                                   20


<210>  22135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22135
gaugcagccu gccccugccu                                                   20


<210>  22136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22136
gccccuaggg ccuccuccug                                                   20


<210>  22137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22137
gcagggccug uaagcaagcc                                                   20


<210>  22138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22138
uacugccacc cgagcaguac                                                   20


<210>  22139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22139
ugugaccgcc ccccccccgg                                                   20


<210>  22140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22140
caggacaagc accuccacgu                                                   20


<210>  22141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22141
ucagcccggg gggggggcgg                                                   20


<210>  22142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22142
cgggcucccg ugccaggggu                                                   20


<210>  22143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22143
ggggcugugg ugguugggga                                                   20


<210>  22144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22144
ccaaccacca cagccccaga                                                   20


<210>  22145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22145
uuccucagag gggugaaugg                                                   20


<210>  22146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22146
uggggugacc uggccggggg                                                   20


<210>  22147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22147
ccccaagaca cccccaaugc                                                   20


<210>  22148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22148
ggcgagguag ggcaugggug                                                   20


<210>  22149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22149
uugagagcca ccucugcuga                                                   20


<210>  22150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22150
cagccuuucu gcugcagccu                                                   20


<210>  22151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22151
agcccccuuc ccaaggccag                                                   20


<210>  22152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22152
ccuccucucc gcccccaacc                                                   20


<210>  22153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22153
ggaucagggu cuccuccucu                                                   20


<210>  22154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22154
ugaccgcgga ggaccggggc                                                   20


<210>  22155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22155
agacaggcag ggguggaguc                                                   20


<210>  22156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22156
uccgcgguca agacaggcag                                                   20


<210>  22157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22157
gggccccggu ccuccgcggu                                                   20


<210>  22158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22158
ggcggugggc ccggccugcc                                                   20


<210>  22159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22159
ucacugggcc ucucugaaca                                                   20


<210>  22160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22160
cccaggcccc cucugggcca                                                   20


<210>  22161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22161
ucacccucag cguggcccag                                                   20


<210>  22162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22162
uccugucccc ugcccgggcc                                                   20


<210>  22163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22163
ccugcccggg ccccgaggcu                                                   20


<210>  22164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22164
ggcccacucc uucuuccuuc                                                   20


<210>  22165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22165
gcaccucuuc cuguugccuc                                                   20


<210>  22166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22166
ggccagagac cccggccugg                                                   20


<210>  22167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22167
cuggccggac aggggaaggg                                                   20


<210>  22168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22168
ccuugagccc accugugcug                                                   20


<210>  22169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22169
uugcgcuggc uuccuccugg                                                   20


<210>  22170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22170
uguccuugcg cuggcuuccu                                                   20


<210>  22171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22171
aggcuggguc uuguccuugc                                                   20


<210>  22172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22172
uuuuuuauuc cuuaguaaau                                                   20


<210>  22173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22173
ggaguucaag accagccuga                                                   20


<210>  22174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22174
ugaacuccug accucaacua                                                   20


<210>  22175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22175
ggcuggucuu gaacuccuga                                                   20


<210>  22176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22176
cagccucccg aguagcuggg                                                   20


<210>  22177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22177
cccaggcugg agugcagugg                                                   20


<210>  22178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22178
cucugucacc caggcuggag                                                   20


<210>  22179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22179
ggaguucaag accagccugg                                                   20


<210>  22180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22180
ugaacuccug accucaggug                                                   20


<210>  22181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22181
cuacuaaaaa uacaaauuag                                                   20


<210>  22182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22182
uaccaccaca cccagcuaau                                                   20


<210>  22183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22183
ccuugguuca agcacuucuc                                                   20


<210>  22184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22184
cacuuuggug cccaggcuag                                                   20


<210>  22185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22185
caaaaaaaua uaugugugug                                                   20


<210>  22186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22186
uucugcugcc uuaaugcauu                                                   20


<210>  22187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22187
acucauuuca gcacuugagg                                                   20


<210>  22188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22188
cuucccucug uccacucauu                                                   20


<210>  22189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22189
gcacaacagg gucccuuccc                                                   20


<210>  22190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22190
cagccugugg cacccgcuga                                                   20


<210>  22191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22191
gcgggugcca caggcuggga                                                   20


<210>  22192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22192
ccaucuguca gcgggugcca                                                   20


<210>  22193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22193
uugggccccu cgcuuaccca                                                   20


<210>  22194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22194
uuugcccuga cccaggagcu                                                   20


<210>  22195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22195
gggcaaagga cgcuggggcc                                                   20


<210>  22196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22196
agauaaaacg ccguaaagug                                                   20


<210>  22197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22197
aagggaggcc gccaagaccg                                                   20


<210>  22198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22198
uggcggccuc ccuuggaccg                                                   20


<210>  22199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22199
cuuucacuca ucaccguggu                                                   20


<210>  22200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22200
caaggcccac ccuguagggc                                                   20


<210>  22201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22201
ggagccacca cgaugggcac                                                   20


<210>  22202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22202
gagaaaccca gccccacugc                                                   20


<210>  22203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22203
acuuccaggg ccuagggacc                                                   20


<210>  22204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22204
cuaggcccug gaaguggaca                                                   20


<210>  22205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22205
gguuuggucc ucagaguccu                                                   20


<210>  22206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22206
ucagaguccu guugcuaaua                                                   20


<210>  22207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22207
uguugcuaau aagcguggag                                                   20


<210>  22208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22208
ucccccucca cgcuuauuag                                                   20


<210>  22209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22209
cuucacuccc ugagccuugc                                                   20


<210>  22210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22210
ccagcuuaag ggaccaaggc                                                   20


<210>  22211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22211
cuuaagcugg agacuagggg                                                   20


<210>  22212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22212
cagccuuggu cccuuaagcu                                                   20


<210>  22213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22213
gagaugcugu cugccucacc                                                   20


<210>  22214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22214
gccucaccug ggcauguggc                                                   20


<210>  22215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22215
aggccacaug cccaggugag                                                   20


<210>  22216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22216
uaguuagaac ugccagucca                                                   20


<210>  22217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22217
cucaugucag aaggugggug                                                   20


<210>  22218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22218
gaaggugggu gccuucucuu                                                   20


<210>  22219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22219
gacucuaugu aaucccaugc                                                   20


<210>  22220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22220
gacagagcau agcuugugca                                                   20


<210>  22221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22221
ugggagcaau cuuccacaug                                                   20


<210>  22222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22222
acgugucugg guggaacaga                                                   20


<210>  22223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22223
ggguggaaca gaugucacaa                                                   20


<210>  22224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22224
caaggaugug agucagaggu                                                   20


<210>  22225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22225
gagguggcug ccucccuaac                                                   20


<210>  22226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22226
gggcucccaa ucuguuaggg                                                   20


<210>  22227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22227
cccucugucu gggcucccaa                                                   20


<210>  22228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22228
caugguaucg ggcacagggg                                                   20


<210>  22229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22229
cuccacucgg ccugaagucu                                                   20


<210>  22230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22230
cucuugcaca gugucacucc                                                   20


<210>  22231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22231
ggcugaccag ccucaccaug                                                   20


<210>  22232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22232
gccggacccu gucucucuug                                                   20


<210>  22233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22233
uggugaggcu ggucagccgg                                                   20


<210>  22234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22234
ccuucugucc cggcaccgcc                                                   20


<210>  22235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22235
cggcaccgcc ugcuccuguu                                                   20


<210>  22236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22236
cugcggaugc guggaccccg                                                   20


<210>  22237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22237
acgcauccgc agagacucgg                                                   20


<210>  22238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22238
uggguccagc agcuccggga                                                   20


<210>  22239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22239
agcagcuccg ggacugcccc                                                   20


<210>  22240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22240
cggagcugcu ggacccagga                                                   20


<210>  22241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22241
ucaguuuccc caggaguaac                                                   20


<210>  22242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22242
ggugcucacc cuagagaaaa                                                   20


<210>  22243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22243
cgcucaaugc ugcugguucc                                                   20


<210>  22244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22244
ugcugagcug ggcccugcgg                                                   20


<210>  22245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22245
ccuggccucc uacccagagc                                                   20


<210>  22246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22246
uuaagguugg ugggcuuccu                                                   20


<210>  22247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22247
cccagagccu ggggccaccu                                                   20


<210>  22248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22248
uaaucgggag aacaaaacga                                                   20


<210>  22249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22249
acuguguucu gagugcgcca                                                   20


<210>  22250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22250
agcagccuag cccuccuauc                                                   20


<210>  22251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22251
ccucuuguga uaggagggcu                                                   20


<210>  22252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22252
cacgcauccc aggagggucu                                                   20


<210>  22253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22253
gguuggcggg agcccucugc                                                   20


<210>  22254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22254
gcagccaggc uggugugggc                                                   20


<210>  22255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22255
cggccacagc ugaucugcuc                                                   20


<210>  22256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22256
cugagcagau cagcuguggc                                                   20


<210>  22257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22257
cccuggaggc ccaggcugcg                                                   20


<210>  22258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22258
cccgagaugg aagaaguggg                                                   20


<210>  22259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22259
acaccccagc uggcuggaac                                                   20


<210>  22260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22260
guucaugcug caggaggcac                                                   20


<210>  22261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22261
cacugggcac uguucaggca                                                   20


<210>  22262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22262
uuggugccug aacagugccc                                                   20


<210>  22263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22263
cccauguccu uggugccuga                                                   20


<210>  22264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22264
gucccccaug uccuuggugc                                                   20


<210>  22265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22265
ggggaggggc agauagccaa                                                   20


<210>  22266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22266
guuggcuauc ugccccuccc                                                   20


<210>  22267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22267
gggggugccg ggugggggcu                                                   20


<210>  22268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22268
acggcagggc ccccacuccu                                                   20


<210>  22269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22269
agcccagggg aguguggucu                                                   20


<210>  22270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22270
agaugagggg ccaaggggca                                                   20


<210>  22271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22271
gugccaaggg ccgcggggag                                                   20


<210>  22272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22272
ccccgcggcc cuuggcacag                                                   20


<210>  22273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22273
ggccgugcuu uuccuuccug                                                   20


<210>  22274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22274
agggaaggga ggaaccgccc                                                   20


<210>  22275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22275
gcgugcaggc uuugguggga                                                   20


<210>  22276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22276
caugcauaga gcggcccucu                                                   20


<210>  22277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22277
ugccccaccc aguggcuccc                                                   20


<210>  22278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22278
cgagaggggc ggcaguccug                                                   20


<210>  22279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22279
cucaccgcag ccagccuggg                                                   20


<210>  22280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22280
accaccccaa guuccuggcu                                                   20


<210>  22281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22281
ugaugugugg ggugggccgg                                                   20


<210>  22282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22282
guguuuguga agaacugaag                                                   20


<210>  22283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22283
caaaccacaa gcagcagagg                                                   20


<210>  22284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22284
gggggaagcc acggcuggca                                                   20


<210>  22285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22285
ccagccccac cucaccgucu                                                   20


<210>  22286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22286
ccagccccac cucacccuca                                                   20


<210>  22287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22287
cgacucccau gcccaucuca                                                   20


<210>  22288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22288
ggacugcccg ggggccucca                                                   20


<210>  22289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22289
ccaggaaagg uucuugagau                                                   20


<210>  22290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22290
cuguccccag gaaagguucu                                                   20


<210>  22291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22291
ucagagggaa gcugcaaugu                                                   20


<210>  22292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22292
gcauuuuucu uaauucccuu                                                   20


<210>  22293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22293
guugcacaca gcaguggccu                                                   20


<210>  22294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22294
ggccacugcu gugugcaacg                                                   20


<210>  22295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22295
cugccuccac ccugcaccgc                                                   20


<210>  22296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22296
ucugggaaca cugcugucuc                                                   20


<210>  22297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22297
ccagugcacc agccuuucuc                                                   20


<210>  22298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22298
cacugggcag agguccaggg                                                   20


<210>  22299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22299
aggggugugg aagggccuca                                                   20


<210>  22300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22300
aauuagcgcu aagucacaau                                                   20


<210>  22301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22301
caauuuuuuc acucugagcu                                                   20


<210>  22302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22302
ggccucaugu auggacauga                                                   20


<210>  22303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22303
auacaugagg ccagacccca                                                   20


<210>  22304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22304
uguccauaca ugaggccaga                                                   20


<210>  22305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22305
gucuguccuu cucuuggguc                                                   20


<210>  22306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22306
guccuucucu uggguccugc                                                   20


<210>  22307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22307
uucucuuggg uccugccaug                                                   20


<210>  22308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22308
ugccaugggc cuggugccca                                                   20


<210>  22309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22309
cacugaaucu ccaaggccca                                                   20


<210>  22310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22310
aagucccacu gaaucuccaa                                                   20


<210>  22311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22311
cuggcacucc ccacgggucc                                                   20


<210>  22312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22312
auggcacagu ucugccacca                                                   20


<210>  22313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22313
ccuccacaug gaaaccaaac                                                   20


<210>  22314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22314
ugcacuugcc ccauccuggu                                                   20


<210>  22315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22315
agugucgggg gcccagggca                                                   20


<210>  22316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22316
ggggcccagg gcaggaaggg                                                   20


<210>  22317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22317
acguggaugg ggugcggcgc                                                   20


<210>  22318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22318
caggccacau ucaccacggc                                                   20


<210>  22319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22319
gcaagccugg cggguguggg                                                   20


<210>  22320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22320
ggcauggcag gugaggcugg                                                   20


<210>  22321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22321
accagccuca ccugccaugc                                                   20


<210>  22322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22322
cagccuugug gagccugucu                                                   20


<210>  22323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22323
cucccugaca ggcacgccca                                                   20


<210>  22324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22324
cgugcugaaa agagaccucc                                                   20


<210>  22325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22325
cuuuucagca cgagacaaac                                                   20


<210>  22326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22326
ugauaaaaug ucaccugcag                                                   20


<210>  22327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22327
ccugcagcca cgcgugcggc                                                   20


<210>  22328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22328
ugccgcacgc guggcugcag                                                   20


<210>  22329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22329
cucuccacgg gaacucaggg                                                   20


<210>  22330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22330
agggaacugc uggccugucc                                                   20


<210>  22331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22331
uuguccccau ggucccaguc                                                   20


<210>  22332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22332
ccaugguccc agucucacug                                                   20


<210>  22333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22333
cagucucacu gucacugugu                                                   20


<210>  22334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22334
cacugucacu gugugcucau                                                   20


<210>  22335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22335
cugugugcuc auguuugaug                                                   20


<210>  22336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22336
ccagcacaga gcccucccca                                                   20


<210>  22337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22337
gcccuggcca ggugguaucu                                                   20


<210>  22338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22338
ccaggcugcc acugugcaga                                                   20


<210>  22339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22339
caaagagccu uggacccuuc                                                   20


<210>  22340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22340
aaggcucuuu gagacccuca                                                   20


<210>  22341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22341
guggagccau ucauucagcu                                                   20


<210>  22342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22342
gggcuucugu uuguuuuuua                                                   20


<210>  22343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22343
cugaaggagu aaguaagucu                                                   20


<210>  22344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22344
ggaggagcug ccugagcuuc                                                   20


<210>  22345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22345
cccuggacug gcggggggug                                                   20


<210>  22346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22346
agggagaccc uguggguggg                                                   20


<210>  22347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22347
ggcagugggc aggggccuga                                                   20


<210>  22348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22348
ggccccugcc cacugccuga                                                   20


<210>  22349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22349
gugccgggua acucagcuuc                                                   20


<210>  22350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22350
gggcucuuuu ugcuccccuu                                                   20


<210>  22351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22351
cuccgcagug uacuggcugg                                                   20


<210>  22352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22352
cccagucccc gagggggcug                                                   20


<210>  22353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22353
ccgagggggc uggcacuugg                                                   20


<210>  22354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22354
uggguacacu gcgcagccua                                                   20


<210>  22355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22355
ggcaccacug cccuucuccc                                                   20


<210>  22356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22356
cuggcuaugg ugagcccccu                                                   20


<210>  22357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22357
uccguggucg cuggcuaugg                                                   20


<210>  22358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22358
cccaccagcc gccgccguug                                                   20


<210>  22359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22359
gcccagggga gggugcauca                                                   20


<210>  22360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22360
ccagccgaug aggaggaagg                                                   20


<210>  22361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22361
ugcagggcac gggcugugcu                                                   20


<210>  22362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22362
ccugaguccu gcagggcacg                                                   20


<210>  22363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22363
cccugaaaua acgccccugc                                                   20


<210>  22364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22364
ccagaugggg acccaccuac                                                   20


<210>  22365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22365
ccaucuggcg acggccugcu                                                   20


<210>  22366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22366
acuuccucua ccucuuccug                                                   20


<210>  22367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22367
ccuucucagc acgcgccacc                                                   20


<210>  22368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22368
aguccuuacu gucuccagag                                                   20


<210>  22369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22369
uuacugucuc cagagggugg                                                   20


<210>  22370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22370
ccagagggug gguccuggcc                                                   20


<210>  22371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22371
uggccacgag cgacagccga                                                   20


<210>  22372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22372
cucguggcca ggacccaccc                                                   20


<210>  22373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22373
guggguugcc aggccagcag                                                   20


<210>  22374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22374
caacaccaag agagcggccc                                                   20


<210>  22375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22375
cagaccacag cccuacccgu                                                   20


<210>  22376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22376
gggacccaca ggccuagggg                                                   20


<210>  22377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22377
cuggcaggaa gcagaagaug                                                   20


<210>  22378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22378
gaggcugcga agagcagggc                                                   20


<210>  22379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22379
uugggguggc cuucucacug                                                   20


<210>  22380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22380
uuucccuagg cggucauugg                                                   20


<210>  22381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22381
cccugugcag cucggguggu                                                   20


<210>  22382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22382
ccaccaggac cccaaaggcc                                                   20


<210>  22383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22383
ugguggugac uucugggccu                                                   20


<210>  22384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22384
aggcauggua agugcacagg                                                   20


<210>  22385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22385
gcaacgaugg ccguggagag                                                   20


<210>  22386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22386
gccucuccac ggccaucguu                                                   20


<210>  22387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22387
gggccaccuc ucggagcuuu                                                   20


<210>  22388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22388
cuuaaggcca ggaguggcuc                                                   20


<210>  22389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22389
ggguugccaa gcccuacucu                                                   20


<210>  22390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22390
cccgagaacc cccuccagga                                                   20


<210>  22391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22391
gagguggccc cagugagugg                                                   20


<210>  22392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22392
ugcaguuucu gugugcgcca                                                   20


<210>  22393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22393
cauuggcucg gcauucucug                                                   20


<210>  22394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22394
cucaggucuc auuggcucgg                                                   20


<210>  22395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22395
ccaucauggg gcugccuggc                                                   20


<210>  22396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22396
uggggcccuc aaggccaaug                                                   20


<210>  22397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22397
agccccgucc ugagggucca                                                   20


<210>  22398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22398
ugagggucca gucaugcugg                                                   20


<210>  22399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22399
agucaugcug ggcccuacac                                                   20


<210>  22400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22400
ugcugggccc uacacucaca                                                   20


<210>  22401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22401
cguucagauc cuuccucauc                                                   20


<210>  22402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22402
uggcuucugg gcaugauccc                                                   20


<210>  22403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22403
ggugcccuug cccacauguc                                                   20


<210>  22404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22404
uugccuuccc acucccuggg                                                   20


<210>  22405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22405
agcccaggcc ccuccccaau                                                   20


<210>  22406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22406
accaaacaua ggaccguaga                                                   20


<210>  22407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22407
uauguuuggu ggacgugguc                                                   20


<210>  22408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22408
uguucggagg uauggcuggc                                                   20


<210>  22409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22409
accccgcccu gccaggagcc                                                   20


<210>  22410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22410
uaggggauga ggaaucacga                                                   20


<210>  22411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22411
gaugggccug gggggcaggg                                                   20


<210>  22412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22412
uugcccugcg gcccacagug                                                   20


<210>  22413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22413
agcaggaggc cgagaaagac                                                   20


<210>  22414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22414
uucucggccu ccugcuggac                                                   20


<210>  22415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22415
ccguugucuu ucucggccuc                                                   20


<210>  22416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22416
gagcagccca ccaugggaug                                                   20


<210>  22417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22417
gguuagcggg gaagccgagu                                                   20


<210>  22418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22418
uccggggccu ggcauacccc                                                   20


<210>  22419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22419
gguguggggg uaugccaggc                                                   20


<210>  22420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22420
guaggccaga gccccugcca                                                   20


<210>  22421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22421
ugagagacca gggugagcac                                                   20


<210>  22422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22422
cucaggaccg uugccuuugc                                                   20


<210>  22423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22423
gcgaugugcu cacccugguc                                                   20


<210>  22424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22424
gggccagggg ccggaaucgc                                                   20


<210>  22425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22425
cccuggcggg ggccaugggg                                                   20


<210>  22426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22426
ggugugcacc ccauggcccc                                                   20


<210>  22427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22427
cggucccgcc cccaccccgc                                                   20


<210>  22428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22428
cgcccccacc ccgcgcgccc                                                   20


<210>  22429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22429
cgccccccac ccugcgcguc                                                   20


<210>  22430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22430
ccggucccgu cccccacccu                                                   20


<210>  22431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22431
cgucccccac ccugcgcgcc                                                   20


<210>  22432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22432
cccacccugc gcgcccucua                                                   20


<210>  22433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22433
agccccacac cccgcgcgcc                                                   20


<210>  22434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22434
cgucuccucc cccaccccgc                                                   20


<210>  22435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22435
ccucccccac cccgcgcguc                                                   20


<210>  22436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22436
ccugucccac ccccaacccg                                                   20


<210>  22437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22437
cacccccaac ccgagcgccc                                                   20


<210>  22438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22438
cgccccgcac cugccgcggc                                                   20


<210>  22439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22439
cgagcgcgca gccgcggcag                                                   20


<210>  22440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22440
gucccgagcg cgcagccgcg                                                   20


<210>  22441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22441
cacagacgcg gaacagggca                                                   20


<210>  22442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22442
gugcgaccgu ccgucccgag                                                   20


<210>  22443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22443
cgccccuggc ggcgugccug                                                   20


<210>  22444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22444
cuuccggggc guggcguggc                                                   20


<210>  22445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22445
guggcggggu ucucgccggu                                                   20


<210>  22446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22446
ugcgggucgc ugcuuggcug                                                   20


<210>  22447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22447
cugcuuggcu guggguuagc                                                   20


<210>  22448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22448
cggccucggg guuacgcggc                                                   20


<210>  22449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22449
ugggcccaag gaggccaggc                                                   20


<210>  22450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22450
gcuccgcggg gcaggcgucg                                                   20


<210>  22451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22451
cccaucgucu gcgcccugcg                                                   20


<210>  22452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22452
gcgcccugcg ggccuggccc                                                   20


<210>  22453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22453
uuccacgggg agggccaggc                                                   20


<210>  22454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22454
gccccccagc guggggcccc                                                   20


<210>  22455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22455
gcucacgcag cccgagcaga                                                   20


<210>  22456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22456
caggacaggc ggcugagggg                                                   20


<210>  22457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22457
ugggacuuca ggcucagcac                                                   20


<210>  22458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22458
cugcccaccc aauucacacc                                                   20


<210>  22459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22459
uguggcuuuc aguugucucu                                                   20


<210>  22460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22460
cccgaaggag gagcuggcgc                                                   20


<210>  22461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22461
ggugcuucug cgcccggaaa                                                   20


<210>  22462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22462
cucugggcag gagaagcuuu                                                   20


<210>  22463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22463
gccacgugag auccgcaagc                                                   20


<210>  22464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22464
uuuuggcugc agguggaaaa                                                   20


<210>  22465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22465
ucugggaaaa aagcuaauaa                                                   20


<210>  22466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22466
gcaaauuuug caauggcagu                                                   20


<210>  22467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22467
cacaaaagca ggcuaauccc                                                   20


<210>  22468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22468
cgcagcggga ggcuacagga                                                   20


<210>  22469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22469
gaauccugua gccucccgcu                                                   20


<210>  22470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22470
ccuggcacca cccaggcuca                                                   20


<210>  22471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22471
guuccugggu gccacaacau                                                   20


<210>  22472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22472
aagcuguuuu cgcacugagu                                                   20


<210>  22473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22473
gagaugaaau cacagggagu                                                   20


<210>  22474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22474
ggucagagau gaaaucacag                                                   20


<210>  22475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22475
gaaguaccca uuggucaggu                                                   20


<210>  22476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22476
cccugagcau cugggguuug                                                   20


<210>  22477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22477
cccacacagc uagcucugcg                                                   20


<210>  22478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22478
agguaacagg gaaggugaac                                                   20


<210>  22479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22479
uugaagaggg cgcgugaucc                                                   20


<210>  22480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22480
ugucauugaa gagggcgcgu                                                   20


<210>  22481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22481
uggaucgcau agcaaggccu                                                   20


<210>  22482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22482
auugaggccu ugcuaugcga                                                   20


<210>  22483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22483
ggucccacuu uuuuuucugu                                                   20


<210>  22484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22484
cacuuuuuuu ucuguccugu                                                   20


<210>  22485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22485
uguucucguu uccucuuugc                                                   20


<210>  22486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22486
ugagugcaaa ggcuuggcuu                                                   20


<210>  22487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22487
cuguguaggc ccaggauuuc                                                   20


<210>  22488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22488
auauacacuu ugucacugug                                                   20


<210>  22489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22489
cauccaccaa cuaggcuggc                                                   20


<210>  22490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22490
gggguuguca cauccaccaa                                                   20


<210>  22491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22491
ggcaggugca cggauccaca                                                   20


<210>  22492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22492
cugagccauc uggggaggcu                                                   20


<210>  22493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22493
gggccugagc cucaucucca                                                   20


<210>  22494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22494
cugucuugcg cuuuccagag                                                   20


<210>  22495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22495
ugcgcuuucc agagagagac                                                   20


<210>  22496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22496
cucucuggaa agcgcaagac                                                   20


<210>  22497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22497
gucucucucu ggaaagcgca                                                   20


<210>  22498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22498
agccauggcu ugaacaccuc                                                   20


<210>  22499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22499
ggcuuuguuc uuguugggag                                                   20


<210>  22500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22500
uugucaccuu ccucaccucc                                                   20


<210>  22501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22501
ccuuccucac cuccccaguc                                                   20


<210>  22502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22502
uagucugguu aauccuuaca                                                   20


<210>  22503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22503
gguuaauccu uacaucucac                                                   20


<210>  22504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22504
ccguggcuag augugaccuc                                                   20


<210>  22505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22505
caucuagcca cggugaccgu                                                   20


<210>  22506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22506
cugugaucuc augaggugug                                                   20


<210>  22507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22507
aguucacacc ucaugagauc                                                   20


<210>  22508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22508
uuagccggca ucccaggaaa                                                   20


<210>  22509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22509
uccccugggg aaugccucgg                                                   20


<210>  22510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22510
ugcaggccga ggcauucccc                                                   20


<210>  22511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22511
caacaagccu ugcaccacga                                                   20


<210>  22512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22512
cucccggguc cagcacaccu                                                   20


<210>  22513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22513
agcacaccug agggcugacc                                                   20


<210>  22514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22514
gcccucaggu gugcuggacc                                                   20


<210>  22515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22515
ugcguaacuu gcacaucuuc                                                   20


<210>  22516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22516
gaaucagaag augugcaagu                                                   20


<210>  22517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22517
gcacagacgc aacccagucu                                                   20


<210>  22518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22518
gugccgaccu gggaugcagu                                                   20


<210>  22519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22519
ccucccaccu ccgagagugc                                                   20


<210>  22520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22520
ugaauggaga accccagcac                                                   20


<210>  22521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22521
uucaguggau gcuucugggu                                                   20


<210>  22522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22522
uacuuacguc cuucagugga                                                   20


<210>  22523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22523
cucugcugga acagccacag                                                   20


<210>  22524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22524
gugguugaca gaaauuacac                                                   20


<210>  22525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22525
accacggacg uuugccuuca                                                   20


<210>  22526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22526
ccaugaggcu uguccagacg                                                   20


<210>  22527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22527
agacgcagug aaccagucgc                                                   20


<210>  22528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22528
ggacaagccu cauggggacu                                                   20


<210>  22529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22529
cagcugauaa cacacagacc                                                   20


<210>  22530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22530
guguguuauc agcugcgacu                                                   20


<210>  22531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22531
ccugaugaaa uagaaugaau                                                   20


<210>  22532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22532
ggaauucgag accagccuga                                                   20


<210>  22533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22533
guccccaccu cucagccaga                                                   20


<210>  22534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22534
ccaccucuca gccagagccu                                                   20


<210>  22535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22535
ucugcucaac ugcagaacug                                                   20


<210>  22536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22536
gccaguucug caguugagca                                                   20


<210>  22537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22537
gcucccacug agcccacagc                                                   20


<210>  22538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22538
aagugugggu gcuggcagca                                                   20


<210>  22539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22539
cacugaagcu uuucacaccc                                                   20


<210>  22540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22540
gcggccggca gagcugcuuc                                                   20


<210>  22541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22541
gugugcucug acacagcucc                                                   20


<210>  22542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22542
gagcacacug accgaaaugg                                                   20


<210>  22543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22543
gggauuucgu guuuuucagg                                                   20


<210>  22544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22544
ucgcagaguc ggggauuucg                                                   20


<210>  22545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22545
aggcagcgug aggacagugc                                                   20


<210>  22546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22546
ucacgcugcc uugacaccac                                                   20


<210>  22547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22547
uggcacagcc ggaacgaagu                                                   20


<210>  22548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22548
ucuugaagag ggagggccgu                                                   20


<210>  22549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22549
ccuccuuuca gagagugcuc                                                   20


<210>  22550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22550
ccauagccug ugcuccucac                                                   20


<210>  22551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22551
acagaacccc ucuuucccag                                                   20


<210>  22552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22552
gggaaagagg gguucuguug                                                   20


<210>  22553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22553
acaccaucuu ugcaaaauca                                                   20


<210>  22554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22554
uuugaugcug cagcuguaag                                                   20


<210>  22555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22555
gucauuugau gcugcagcug                                                   20


<210>  22556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22556
gccaggugau ccgugaggag                                                   20


<210>  22557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22557
cugccauccu uccacgccau                                                   20


<210>  22558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22558
ugccuggcug ugggccuggc                                                   20


<210>  22559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22559
gugagggcag gaggcaagag                                                   20


<210>  22560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22560
aacuuguucu guuugucacu                                                   20


<210>  22561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22561
ccucacauac cggaugugau                                                   20


<210>  22562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22562
aaguuggggc ccucagucua                                                   20


<210>  22563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22563
acucgcccag cggagggaga                                                   20


<210>  22564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22564
gcuagagagg auguggccac                                                   20


<210>  22565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22565
cacuuggaau ucagguucca                                                   20


<210>  22566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22566
ugucgcacuu ggaauucagg                                                   20


<210>  22567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22567
cagagguuua uaccugagcu                                                   20


<210>  22568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22568
uggagggaca ggauggggca                                                   20


<210>  22569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22569
cuccaggacg uggugaaggg                                                   20


<210>  22570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22570
ugggacgaug ucaugccaug                                                   20


<210>  22571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22571
caggacagua accccccaua                                                   20


<210>  22572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22572
gccugcugca ccacgggugg                                                   20


<210>  22573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22573
gcugcucacc aaggugcguu                                                   20


<210>  22574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22574
ccacugggug ccagaagucg                                                   20


<210>  22575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22575
gaaguuggaa auagcagccc                                                   20


<210>  22576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22576
aggcacugcc ccugccacag                                                   20


<210>  22577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22577
caaucauuuc uuccaucuca                                                   20


<210>  22578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22578
cuugcagauu caggaaacau                                                   20


<210>  22579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22579
ggagagaaug acuuuagaua                                                   20


<210>  22580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22580
uucucuccug acuuuacauu                                                   20


<210>  22581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22581
ucugggaugu gggguuaagc                                                   20


<210>  22582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22582
uugauaaguu gguuguguaa                                                   20


<210>  22583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22583
ggugggucau cuguagccaa                                                   20


<210>  22584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22584
ucuguagcca aaucgccaac                                                   20


<210>  22585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22585
cgcagaagga aacaaagcaa                                                   20


<210>  22586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22586
cgcucuguug cccaggcugg                                                   20


<210>  22587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22587
cugguagcuu uuccagcucu                                                   20


<210>  22588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22588
aaguggcuau cugggcuguc                                                   20


<210>  22589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22589
cucuccucug uguccucccc                                                   20


<210>  22590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22590
uccccgccug aacugucacc                                                   20


<210>  22591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22591
ccuucuuccu cguugcucuc                                                   20


<210>  22592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22592
cuggcuuccu ugcuuugcuc                                                   20


<210>  22593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22593
aggaagagca aagcaaggaa                                                   20


<210>  22594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22594
aggaagaugu ccaggaagag                                                   20


<210>  22595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22595
ucaugcccug ugguuuccac                                                   20


<210>  22596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22596
ucuuuaucua gcacgaagcc                                                   20


<210>  22597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22597
gcagaugauc ugaaugaugg                                                   20


<210>  22598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22598
cucagccuga gcaggaagga                                                   20


<210>  22599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22599
uagagcacac ucuuccaaca                                                   20


<210>  22600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22600
ucauccuguu agagggcugc                                                   20


<210>  22601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22601
uaugcaucgg gcuaagguag                                                   20


<210>  22602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22602
cuguucucug acuugggagu                                                   20


<210>  22603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22603
gagaacagag acaaaaagga                                                   20


<210>  22604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22604
cacaaaacuc ccaagucaga                                                   20


<210>  22605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22605
gaauuucuuu ccagucuugg                                                   20


<210>  22606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22606
uggucuagcu ucuccgugag                                                   20


<210>  22607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22607
agcuucuccg ugagcucgag                                                   20


<210>  22608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22608
cucccucugg ggaaaaaaua                                                   20


<210>  22609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22609
guuauuuuuu ccccagaggg                                                   20


<210>  22610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22610
aaacaagaga agguggguua                                                   20


<210>  22611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22611
cggaaagagc ugauugaaga                                                   20


<210>  22612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22612
ucuugugaag gagcccaccg                                                   20


<210>  22613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22613
gcucagcugg gggcaaaagg                                                   20


<210>  22614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22614
ccaggcccug cccagggagg                                                   20


<210>  22615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22615
ccuguaccac ggcgcccccu                                                   20


<210>  22616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22616
ccugcacgcc acggcgcccc                                                   20


<210>  22617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22617
guuuuagauu uguacaccuu                                                   20


<210>  22618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22618
cauuuccagc aucuucagaa                                                   20


<210>  22619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22619
gagcuguggg gagaacccac                                                   20


<210>  22620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22620
ggugaggcug gggugcugug                                                   20


<210>  22621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22621
cuguccacaa ugucauuaug                                                   20


<210>  22622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22622
acaaugucau uaugcuucuc                                                   20


<210>  22623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22623
uuaugcuucu cgaugucugc                                                   20


<210>  22624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22624
gccaaagacu ggccauaaug                                                   20


<210>  22625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22625
uuggcagaca ucgagaagca                                                   20


<210>  22626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22626
auucuucauc uucauuuaga                                                   20


<210>  22627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22627
cugacagaag agaaaaaaag                                                   20


<210>  22628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22628
gcgacaucau gagaaaaaaa                                                   20


<210>  22629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22629
guguacgcug gaaaacaggu                                                   20


<210>  22630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22630
gaaacaaucu cacaaaaaau                                                   20


<210>  22631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22631
uggagguuga auucccuaaa                                                   20


<210>  22632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22632
ucucacagcu uucuuuaggg                                                   20


<210>  22633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22633
agcuggcaau cagaugggag                                                   20


<210>  22634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22634
guacagaguu caucgagcag                                                   20


<210>  22635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22635
cuggcuucua gcaggaaggg                                                   20


<210>  22636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22636
caacaucuau auaguuuaag                                                   20


<210>  22637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22637
cuuacaguug gucaggccuu                                                   20


<210>  22638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22638
cgcgcacggg cccucaggaa                                                   20


<210>  22639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22639
cacgucgugg cgcgucuucc                                                   20


<210>  22640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22640
uggcgcgucu uccggcccag                                                   20


<210>  22641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22641
uccggcccag gaucuggaac                                                   20


<210>  22642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22642
gggcgcgaag gaaggccucc                                                   20


<210>  22643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22643
cgggcccuug ggcgcagcgg                                                   20


<210>  22644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22644
uaggguagcg cgcgccuguc                                                   20


<210>  22645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22645
cgcgagaaca gcgcagcacc                                                   20


<210>  22646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22646
gaggugcugc gcuguucucg                                                   20


<210>  22647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22647
cugagccuau cggcgaguaa                                                   20


<210>  22648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22648
ccggccgcgg cgggcgcccc                                                   20


<210>  22649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22649
ccgcugccgc gcuaucgccc                                                   20


<210>  22650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22650
cagcugucac cgcugccgcg                                                   20


<210>  22651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22651
ggcugccccc uccccucgcc                                                   20


<210>  22652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22652
ccucggucuc gcagaauccg                                                   20


<210>  22653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22653
cgcagaaucc gccggcggcg                                                   20


<210>  22654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22654
uggcgccgcc gccgccggcg                                                   20


<210>  22655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22655
aggugggugc gcggcaggcg                                                   20


<210>  22656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22656
ggggcgccug ccgcgcaccc                                                   20


<210>  22657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22657
cggaccucau gucucccuug                                                   20


<210>  22658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22658
gagacagagg auugcacaga                                                   20


<210>  22659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22659
cccuugccug cgucucaaga                                                   20


<210>  22660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22660
caagagagcu ggcgacagag                                                   20


<210>  22661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22661
ccagcucucu ugagacgcag                                                   20


<210>  22662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22662
gaggcucugu cgccagcucu                                                   20


<210>  22663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22663
cugugcuagc cacgguaguu                                                   20


<210>  22664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22664
cacuauguug cccaggcuag                                                   20


<210>  22665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22665
ggaaccccug gacucaagug                                                   20


<210>  22666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22666
agggguucca gacuagccug                                                   20


<210>  22667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22667
gauauuugaa guaaucuaug                                                   20


<210>  22668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22668
gccaaauuau uucucugcca                                                   20


<210>  22669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22669
accgucuguu acuaucauua                                                   20


<210>  22670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22670
aaauauaaag cucaagaaca                                                   20


<210>  22671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22671
aaaucauuuu ggcuuuauua                                                   20


<210>  22672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22672
uggucauaaa gacuaauuug                                                   20


<210>  22673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22673
uaaagacuaa uuugguaaca                                                   20


<210>  22674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22674
uuaugaccau gacauaaaug                                                   20


<210>  22675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22675
ccaguaaaua ugugguuaau                                                   20


<210>  22676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22676
cauauuacau uuuugugcuu                                                   20


<210>  22677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22677
aauuuuccau uuuuauaagg                                                   20


<210>  22678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22678
uuaggguggg cccuaaucca                                                   20


<210>  22679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22679
cuauaaauac ccuaucucca                                                   20


<210>  22680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22680
gaggguuagg ggcuaacugg                                                   20


<210>  22681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22681
ggcuggcucc aaagcccaug                                                   20


<210>  22682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22682
guuacuucag uuucacucaa                                                   20


<210>  22683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22683
uuucagaguu acuucccuug                                                   20


<210>  22684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22684
gcuuuuuguu cucugugucu                                                   20


<210>  22685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22685
gcuugcuuca gcccuuuucu                                                   20


<210>  22686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22686
guugcuguau uaaucuaucc                                                   20


<210>  22687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22687
gccaaauaaa agcuuccucu                                                   20


<210>  22688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22688
cagcugcuga ggaggcugag                                                   20


<210>  22689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22689
aggaagucaa ggcugcagug                                                   20


<210>  22690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22690
aggcugcagu gagacuugca                                                   20


<210>  22691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22691
cacugcagcc uugacuuccu                                                   20


<210>  22692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22692
cccaggcuag aaugcagaau                                                   20


<210>  22693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22693
ugcucuguca cccaggcuag                                                   20


<210>  22694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22694
uucacuacug guccagaucc                                                   20


<210>  22695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22695
agaucccaug ccugccaagg                                                   20


<210>  22696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22696
guguaccuca uucuuccugg                                                   20


<210>  22697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22697
cucaauaaag caccucuucu                                                   20


<210>  22698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22698
ccugagagcu guacugucac                                                   20


<210>  22699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22699
gugcagcccu cagaggagag                                                   20


<210>  22700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22700
ggcuucaguc uaucccuggc                                                   20


<210>  22701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22701
aucccuggcu ugaaggugag                                                   20


<210>  22702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22702
ccagugaaac cucaccuuca                                                   20


<210>  22703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22703
gccuccugcc cuuguucaug                                                   20


<210>  22704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22704
aaagucugga gggggcugag                                                   20


<210>  22705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22705
ggagggggcu gagguggcag                                                   20


<210>  22706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22706
uauucauauu ucacuaucuc                                                   20


<210>  22707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22707
cucuuggucu uauucauauu                                                   20


<210>  22708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22708
cagggcacuu guagaucaug                                                   20


<210>  22709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22709
cuugccugau gcaguauuuu                                                   20


<210>  22710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22710
agggugaaca uguugaaugc                                                   20


<210>  22711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22711
agagcaccug gcauucaaca                                                   20


<210>  22712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22712
cacaccacaa gauguccaga                                                   20


<210>  22713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22713
agagcucaug aucucaguug                                                   20


<210>  22714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22714
uguuagaucu uguuuacaga                                                   20


<210>  22715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22715
uaguaaaaaa uggaaggaga                                                   20


<210>  22716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22716
guaucuccuu ccauuuuuua                                                   20


<210>  22717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22717
gccagugcag ugagcuuaga                                                   20


<210>  22718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22718
aagcucacug cacuggcuga                                                   20


<210>  22719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22719
acagccaacu uuauaacugc                                                   20


<210>  22720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22720
caccauguug cccaggcugg                                                   20


<210>  22721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22721
uggggagagg aauuuuuacu                                                   20


<210>  22722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22722
guagaagaaa cacuguuaag                                                   20


<210>  22723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22723
ggaaggcuac uaaacaauac                                                   20


<210>  22724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22724
guuccaaucu uuuauccguu                                                   20


<210>  22725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22725
uuuuguuguu gagguauaag                                                   20


<210>  22726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22726
accacaugcu guucuaagcc                                                   20


<210>  22727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22727
uugugacaag caaccgauag                                                   20


<210>  22728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22728
caaagacugc uauaauccuu                                                   20


<210>  22729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22729
uccuaucggu ugcuugucac                                                   20


<210>  22730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22730
cuucaggcag uucugugaua                                                   20


<210>  22731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22731
ggagaucgag accauccuga                                                   20


<210>  22732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22732
cgaucuccug accucaugau                                                   20


<210>  22733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22733
ggauggucuc gaucuccuga                                                   20


<210>  22734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22734
cuacuaaaau acaaaaaguu                                                   20


<210>  22735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22735
cagcuacuug ggaggcugag                                                   20


<210>  22736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22736
ggauucaacc agagaacuag                                                   20


<210>  22737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22737
ucaggcagaa uuucuuccuc                                                   20


<210>  22738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22738
uccuggagga agaaauucug                                                   20


<210>  22739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22739
ucaucaucgg caacuucaua                                                   20


<210>  22740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22740
acaaucacuu cgguccucau                                                   20


<210>  22741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22741
aucuuagaua gauucuucaa                                                   20


<210>  22742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22742
ggcaucacac ccagccaaau                                                   20


<210>  22743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22743
cacuauguug gccaugcuga                                                   20


<210>  22744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22744
agcuaguuuu uuuguuuauu                                                   20


<210>  22745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22745
ugaggaaacu aacaauuaga                                                   20


<210>  22746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22746
cucuuggacu aaaaauaaca                                                   20


<210>  22747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22747
aagagagaca aauaaaauuc                                                   20


<210>  22748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22748
acaacaccuu gaacugggca                                                   20


<210>  22749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22749
cagcuucuuc auuuuagguc                                                   20


<210>  22750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22750
aaguaaacuc uuuaaauuac                                                   20


<210>  22751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22751
uucacauuua aguaugaugu                                                   20


<210>  22752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22752
gguaaggcug caagauacua                                                   20


<210>  22753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22753
cuauacaaaa uuuaauugua                                                   20


<210>  22754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22754
uuccauuucu ugagaucuuc                                                   20


<210>  22755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22755
ucugauccac gaacaggaga                                                   20


<210>  22756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22756
ugauuacugu agcuuuguac                                                   20


<210>  22757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22757
uggcaugaug guagacauac                                                   20


<210>  22758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22758
accaucaugc caggaccaua                                                   20


<210>  22759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22759
augguaugga aucgagagug                                                   20


<210>  22760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22760
ugauagaauc aaccugcuau                                                   20


<210>  22761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22761
caauuuuucu gaaacuaaau                                                   20


<210>  22762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22762
uuacuaaaaa auacaaaaau                                                   20


<210>  22763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22763
ugaacuccug accucaacug                                                   20


<210>  22764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22764
ggaguucaag accagccugg                                                   20


<210>  22765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22765
aaaagguuua uccaaguugu                                                   20


<210>  22766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22766
guggaugaau ggauaaauaa                                                   20


<210>  22767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22767
caaacaggua ucugcacacc                                                   20


<210>  22768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22768
cuacuaaaaa uacaaaacua                                                   20


<210>  22769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22769
caaacuccug acuucaggug                                                   20


<210>  22770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22770
ggaguuugag accagccaac                                                   20


<210>  22771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22771
caacaucugg agguauuucu                                                   20


<210>  22772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22772
caaucuacau ucugucacaa                                                   20


<210>  22773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22773
gcaugcauac acaaggcacu                                                   20


<210>  22774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22774
cucaugucac agcggaggaa                                                   20


<210>  22775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22775
cagcggagga aacggaggcc                                                   20


<210>  22776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22776
cuggcugggu gccauggcuc                                                   20


<210>  22777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22777
ugggauauug ugauaagaau                                                   20


<210>  22778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22778
ucaucuggga ugccacagag                                                   20


<210>  22779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22779
acgcuuuugu ccuucacauc                                                   20


<210>  22780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22780
uucacauccc ucuccugggc                                                   20


<210>  22781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22781
cucagccagu gaguggcuga                                                   20


<210>  22782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22782
gcuguucugu uaucaagcag                                                   20


<210>  22783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22783
cagcuacuca ggaggcugag                                                   20


<210>  22784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22784
ugggcuuaag caauccuuca                                                   20


<210>  22785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22785
auuaaauuag aagaaauggu                                                   20


<210>  22786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22786
ccagggcugg agugcagugg                                                   20


<210>  22787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22787
cacucugucg ccagggcugg                                                   20


<210>  22788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22788
agagcuaucc ugcuagaggg                                                   20


<210>  22789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22789
cugagcacag acacccuuug                                                   20


<210>  22790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22790
gugcucaggg acuguggcuc                                                   20


<210>  22791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22791
cgggcauccc cuuugagcag                                                   20


<210>  22792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22792
ucgccucauu uauugaacca                                                   20


<210>  22793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22793
cacauugcau uguucuuuua                                                   20


<210>  22794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22794
aaauguguuc uuuguuacgg                                                   20


<210>  22795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22795
ugagaacaug gcuucaggua                                                   20


<210>  22796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22796
ccaagagaag ggauucuuaa                                                   20


<210>  22797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22797
cuuugcccag auggaaagac                                                   20


<210>  22798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22798
uuccaucugg gcaaagugac                                                   20


<210>  22799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22799
uaaauguaug gaaauagaau                                                   20


<210>  22800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22800
caaauucaca uaguacagag                                                   20


<210>  22801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22801
aaacagagua ggguuacgua                                                   20


<210>  22802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22802
auuugggaaa auccuaagga                                                   20


<210>  22803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22803
uuuccuuagg auuuucccaa                                                   20


<210>  22804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22804
gugagucauu uccuuaggau                                                   20


<210>  22805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22805
aggcaacaag agcgaaacuc                                                   20


<210>  22806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22806
ggguggucuu gaacucccga                                                   20


<210>  22807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22807
ugaacucccg accucgggug                                                   20


<210>  22808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22808
ggaguucaag accacccuga                                                   20


<210>  22809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22809
ccuagaugga gaccacugua                                                   20


<210>  22810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22810
ccaucuagga gacccaucau                                                   20


<210>  22811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22811
ggggauuuaa agagauauua                                                   20


<210>  22812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22812
cuaagagcca ggcaagccau                                                   20


<210>  22813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22813
cacccgggca guguaaccug                                                   20


<210>  22814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22814
gcuuucuaau uaacuucaag                                                   20


<210>  22815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22815
agcugcaggu gcauaacaga                                                   20


<210>  22816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22816
ugucaagcug caggugcaua                                                   20


<210>  22817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22817
cucugguaca guuccagaga                                                   20


<210>  22818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22818
cuggaacugu accagaggga                                                   20


<210>  22819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22819
uagaacagga aagucauuuu                                                   20


<210>  22820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22820
uuuucuuacu uggacucuug                                                   20


<210>  22821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22821
aaguaagaaa augacuuucc                                                   20


<210>  22822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22822
uuacauuugc agaucauuaa                                                   20


<210>  22823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22823
uguguuuaca aaggaaugaa                                                   20


<210>  22824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22824
aauuauagcc acauguaagu                                                   20


<210>  22825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22825
gucuuaauag gauauaauag                                                   20


<210>  22826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22826
uaauaggaua uaauagggac                                                   20


<210>  22827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22827
cuauuauauc cuauuaagac                                                   20


<210>  22828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22828
uucacaauag cuaaaauuug                                                   20


<210>  22829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22829
ugccauguug ccuaggcuga                                                   20


<210>  22830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22830
uucuuaucuu cuuuuuuaau                                                   20


<210>  22831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22831
gugggaaacu gccaugcuuu                                                   20


<210>  22832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22832
aggcccagag gcagugagca                                                   20


<210>  22833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22833
gcucaccccu acucugaaug                                                   20


<210>  22834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22834
gaaggagccc ugcuugcccu                                                   20


<210>  22835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22835
ccgcaugagg gcaagcaggg                                                   20


<210>  22836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22836
acaguaauuc uuucgcuuau                                                   20


<210>  22837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22837
uccgaaauga auuuguaggg                                                   20


<210>  22838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22838
ugagugagca caaugguaaa                                                   20


<210>  22839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22839
acucaauucc uuuaccauug                                                   20


<210>  22840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22840
ugguuuuagg ccacagacug                                                   20


<210>  22841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22841
guggccuaaa accaugacag                                                   20


<210>  22842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22842
gaaguacgug cucuuuccac                                                   20


<210>  22843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22843
gcccacgucu gaaguacgug                                                   20


<210>  22844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22844
ggguccuguc guaucacuuc                                                   20


<210>  22845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22845
ugucguauca cuuccagcag                                                   20


<210>  22846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22846
uaucacuucc agcagcguga                                                   20


<210>  22847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22847
gcuuuccauu cccuuucucu                                                   20


<210>  22848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22848
uuaucuugga auuacgggug                                                   20


<210>  22849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22849
uuauuacuuc caauauuuuc                                                   20


<210>  22850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22850
cugccaguga gggucucauc                                                   20


<210>  22851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22851
caucaagcaa agagcuuccu                                                   20


<210>  22852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22852
accuggcauu ucuuaggcca                                                   20


<210>  22853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22853
agugcgagcc acaggaaaaa                                                   20


<210>  22854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22854
ccucuuaguc uucacugugc                                                   20


<210>  22855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22855
ucacugugca uuguuugauu                                                   20


<210>  22856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22856
gccgacaugc cgcucagcuc                                                   20


<210>  22857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22857
gcugacaaaa gugcuaugaa                                                   20


<210>  22858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22858
uuucuuguuu ucugaguuua                                                   20


<210>  22859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22859
cccgccuccc auucugucac                                                   20


<210>  22860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22860
cucuucacac cugccagcuu                                                   20


<210>  22861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22861
auuaguuacc cguguuucuu                                                   20


<210>  22862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22862
auuucucugg ccccugggac                                                   20


<210>  22863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22863
caggggccag agaaauugac                                                   20


<210>  22864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22864
caguguccca ggggccagag                                                   20


<210>  22865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22865
aaaaaaaaaa aaaaaaagag                                                   20


<210>  22866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22866
aggcuggagc gcaauggcac                                                   20


<210>  22867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22867
cugcagccuc aaccuuccag                                                   20


<210>  22868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22868
cccugcacaa agcagcuaac                                                   20


<210>  22869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22869
cacucuguca cccaggcugg                                                   20


<210>  22870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22870
cacaccacca ugccuggcua                                                   20


<210>  22871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22871
cagcuacuca gaaggcugug                                                   20


<210>  22872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22872
gggcugcagu gagccauuau                                                   20


<210>  22873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22873
cccaggcugg agugcagugg                                                   20


<210>  22874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22874
cuagguuccu ugggagaggc                                                   20


<210>  22875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22875
ugauguauua aaacaguaac                                                   20


<210>  22876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22876
ccacgcccgg cuaauuuuug                                                   20


<210>  22877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22877
cccagguuuc aagcgauucu                                                   20


<210>  22878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22878
uuagguuagu uuagccuacg                                                   20


<210>  22879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22879
uggagccggu uucucccagc                                                   20


<210>  22880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22880
cuuacacuau uggaaauaug                                                   20


<210>  22881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22881
gagggcccug gguguuuuuu                                                   20


<210>  22882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22882
cugauauaaa auggugcaaa                                                   20


<210>  22883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22883
ucaagucccu gauauaaaau                                                   20


<210>  22884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22884
cacagcaggc cccuuucccu                                                   20


<210>  22885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22885
cccuugucac cuuguaagcc                                                   20


<210>  22886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22886
ccuuguaagc cuggcccucg                                                   20


<210>  22887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22887
ugcugcuccc acacccccug                                                   20


<210>  22888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22888
ucacuucauu guaccuuugc                                                   20


<210>  22889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22889
uucugagaga cuccugcuca                                                   20


<210>  22890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22890
cucagaauga caggaagagg                                                   20


<210>  22891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22891
gcucagaugg ucacgucaga                                                   20


<210>  22892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22892
cgucagacga ugagcuucuu                                                   20


<210>  22893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22893
gacgaugagc uucuugggag                                                   20


<210>  22894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22894
gacgugacca ucugagcaga                                                   20


<210>  22895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22895
uugaucucau uucuuccuau                                                   20


<210>  22896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22896
aucagaauag gaagaaauga                                                   20


<210>  22897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22897
uuaagagaua uuuaucccau                                                   20


<210>  22898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22898
cugguccuua agagauauuu                                                   20


<210>  22899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22899
gccccacugc caagccuggu                                                   20


<210>  22900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22900
ucuagacaca gagguggucg                                                   20


<210>  22901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22901
agaggacuca uagccagggc                                                   20


<210>  22902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22902
ccugaguuga ggaagccuug                                                   20


<210>  22903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22903
ggugguauug gaccauggaa                                                   20


<210>  22904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22904
aauaccacca gacucuuacc                                                   20


<210>  22905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22905
ccugugaagu gugauuuacu                                                   20


<210>  22906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22906
caagaugagc uggauuuucu                                                   20


<210>  22907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22907
gccccaucca ccgcuguguc                                                   20


<210>  22908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22908
acgggacuca ccaucaguag                                                   20


<210>  22909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22909
cguggacaca gcgguggaug                                                   20


<210>  22910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22910
uucauucaac aaaugcuuag                                                   20


<210>  22911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22911
cagugacauu cccaccucag                                                   20


<210>  22912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22912
cugggaccau cggucauuca                                                   20


<210>  22913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22913
cagcuacuca gggggcugag                                                   20


<210>  22914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22914
uuaaugaacg uggcacaauu                                                   20


<210>  22915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22915
ucaaaucugu auaacuaugc                                                   20


<210>  22916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22916
ucacauguga guuguuugcu                                                   20


<210>  22917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22917
caugugaguu guuugcugag                                                   20


<210>  22918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22918
ugccuguuug ccguggcuca                                                   20


<210>  22919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22919
cuacaagaaa caacaacaaa                                                   20


<210>  22920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22920
acccauuaga ugugaaaggc                                                   20


<210>  22921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22921
cucuaacaaa gucuacccau                                                   20


<210>  22922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22922
acuuucugca uccaacuuuc                                                   20


<210>  22923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22923
guauuucauc uuuuuaaaau                                                   20


<210>  22924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22924
uuccccugug uuuaggcaag                                                   20


<210>  22925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22925
uaauuuucaa uuaaugauug                                                   20


<210>  22926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22926
gggucuugcu gugucgccca                                                   20


<210>  22927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22927
ugcugugucg cccaggcugg                                                   20


<210>  22928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22928
cccaggcugg agugcagugg                                                   20


<210>  22929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22929
uuugagccca guaguucaag                                                   20


<210>  22930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22930
cagcuaugca gaaagcugag                                                   20


<210>  22931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22931
ugcuauguug cccaggcugu                                                   20


<210>  22932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22932
uccugccuuc ccucccaaag                                                   20


<210>  22933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22933
gaacguuuuc ucccucuugu                                                   20


<210>  22934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22934
acagcaagaa acaagaggga                                                   20


<210>  22935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22935
uguugccccu ggugcugucc                                                   20


<210>  22936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22936
ucuugucaca uagcaugugu                                                   20


<210>  22937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22937
cauagcaugu gucacagagc                                                   20


<210>  22938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22938
cagagcaggg ugcagauggc                                                   20


<210>  22939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22939
ccaagcagcc aucugcaccc                                                   20


<210>  22940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22940
acuauuacag ggucuccaag                                                   20


<210>  22941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22941
gcagcauggg ugcacacucc                                                   20


<210>  22942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22942
uacccagaau gcaaggaugg                                                   20


<210>  22943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22943
uacagucuag uagagcacac                                                   20


<210>  22944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22944
aguagagcac acauggcaag                                                   20


<210>  22945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22945
guggcuccug ccgagaagag                                                   20


<210>  22946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22946
ucuucucggc aggagccacu                                                   20


<210>  22947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22947
aaggcggaga uugagggcag                                                   20


<210>  22948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22948
ugggggacuu ggaaugcuag                                                   20


<210>  22949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22949
cccacgacug cccucaaucu                                                   20


<210>  22950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22950
ccuuuuaugc cucugccaga                                                   20


<210>  22951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22951
uacaugaauu agauaagcau                                                   20


<210>  22952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22952
gauuccuaaa ucuugguauc                                                   20


<210>  22953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22953
aagguugugu ccguagcucc                                                   20


<210>  22954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22954
guagcuccug acuuagccug                                                   20


<210>  22955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22955
ggagcuacgg acacaaccuu                                                   20


<210>  22956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22956
cuuuauguuu cuuuauguuu                                                   20


<210>  22957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22957
uuccccagug cuaacuccug                                                   20


<210>  22958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22958
ugcuaaguua gccaggcagg                                                   20


<210>  22959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22959
cuucucuugg ggaccacagu                                                   20


<210>  22960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22960
ccaagagaag agacagggaa                                                   20


<210>  22961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22961
ucugaugccg augaccacag                                                   20


<210>  22962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22962
ucggcaucag aggacugugg                                                   20


<210>  22963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22963
gggucucucu augcuaccca                                                   20


<210>  22964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22964
cucuaugcua cccaggcugg                                                   20


<210>  22965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22965
cuuaggccca ggaguuucag                                                   20


<210>  22966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22966
aaacugcagu gaggcauaau                                                   20


<210>  22967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22967
agaguucgag accagccugg                                                   20


<210>  22968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22968
cgaacucuug accucaagug                                                   20


<210>  22969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22969
cuacuaaaaa uacaaaaauu                                                   20


<210>  22970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22970
cccaggcugg aguguagugg                                                   20


<210>  22971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22971
cacucugucg cccaggcugg                                                   20


<210>  22972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22972
caaaaaacaa acaaacaaac                                                   20


<210>  22973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22973
uuagcaaaag uucuuugguu                                                   20


<210>  22974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22974
cucagaggcc gggcacagug                                                   20


<210>  22975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22975
ggaguucaag accagccugg                                                   20


<210>  22976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22976
ugaacuccug acuucaggug                                                   20


<210>  22977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22977
cuacuaaaaa uacaaaaauu                                                   20


<210>  22978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22978
cagcuacuug aggggcugag                                                   20


<210>  22979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22979
ccuaggcugg agugcaaugg                                                   20


<210>  22980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22980
cacucuguca ccuaggcugg                                                   20


<210>  22981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22981
caaaaaaaaa aaaaaaaaaa                                                   20


<210>  22982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22982
cucaguauca uucccuucug                                                   20


<210>  22983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22983
caaaaaaaaa aaaaaaaaaa                                                   20


<210>  22984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22984
ugcucugucg cccaggcugg                                                   20


<210>  22985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22985
cccaggcugg ugugcagugg                                                   20


<210>  22986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22986
cagcugcuug ggaggcugag                                                   20


<210>  22987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22987
cuacuaaaaa aaauauaaaa                                                   20


<210>  22988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22988
cgaucuccug accuugugau                                                   20


<210>  22989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22989
ggagaucgag accauccugg                                                   20


<210>  22990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22990
agauuccauc ccugaccauc                                                   20


<210>  22991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22991
gggauggaau cuagacaucu                                                   20


<210>  22992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22992
acuacuuuau uuaagaaaug                                                   20


<210>  22993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22993
uccacguggc uauuucacug                                                   20


<210>  22994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22994
augaguguug cagagccauc                                                   20


<210>  22995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22995
gucugcugug ccuccugcag                                                   20


<210>  22996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22996
gcugugccuc cugcaggcga                                                   20


<210>  22997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22997
gguucgccug caggaggcac                                                   20


<210>  22998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22998
ucuccaccgg ugcuguuucc                                                   20


<210>  22999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  22999
uagaaguggg ugaauucaua                                                   20


<210>  23000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23000
gauauugcca gauuccgcuc                                                   20


<210>  23001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23001
gcauucccac cagcagugca                                                   20


<210>  23002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23002
gcuggcgagg cuguggggaa                                                   20


<210>  23003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23003
guuuguuagc ugggaauugg                                                   20


<210>  23004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23004
uauuuuucuu auaaaaaugg                                                   20


<210>  23005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23005
caacauguua gcacucuacu                                                   20


<210>  23006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23006
ugaacuccug ggcucaagcg                                                   20


<210>  23007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23007
uguugcccag gcuggucuug                                                   20


<210>  23008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23008
cuacaaaaga aaagaaaaga                                                   20


<210>  23009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23009
caguuuccuc cccuuguaca                                                   20


<210>  23010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23010
uggcucugcc auguacuauc                                                   20


<210>  23011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23011
gaguccuggc ucugccaugu                                                   20


<210>  23012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23012
gugcuccuca ccccugugcu                                                   20


<210>  23013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23013
gaggccggcu uuccucucua                                                   20


<210>  23014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23014
gcaugaugcu uuagagagga                                                   20


<210>  23015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23015
uuuuaaaaca gucugcauga                                                   20


<210>  23016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23016
cauauuuuua guuuuuagca                                                   20


<210>  23017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23017
gcuuccaggg cuggcuaauc                                                   20


<210>  23018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23018
caaaaaaauu auaaagaaaa                                                   20


<210>  23019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23019
aggcugcggu gaaccaugau                                                   20


<210>  23020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23020
cagcuacucu ggaggcugag                                                   20


<210>  23021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23021
cuauaaaaaa agauuuuuaa                                                   20


<210>  23022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23022
ugucauguuu cccaggcugg                                                   20


<210>  23023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23023
uguuucccag gcuggucuca                                                   20


<210>  23024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23024
caaaaugugg aacucaagua                                                   20


<210>  23025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23025
gaggauuacu ugaguuccac                                                   20


<210>  23026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23026
ggccuaauuu guuaguucca                                                   20


<210>  23027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23027
gggaaauaau aaacaaaauu                                                   20


<210>  23028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23028
cuguguauag uacugguacu                                                   20


<210>  23029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23029
gaguaccagu acuauacaca                                                   20


<210>  23030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23030
uacaacuucc agguacauca                                                   20


<210>  23031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23031
uaucaagugg uggccuauga                                                   20


<210>  23032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23032
uuacuucccc cgugaccugu                                                   20


<210>  23033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23033
cgggggaagu aaugacaccg                                                   20


<210>  23034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23034
uguguguuca aauauguuau                                                   20


<210>  23035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23035
gaaauccgga uguguccugu                                                   20


<210>  23036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23036
uucugggauc ucuguggcca                                                   20


<210>  23037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23037
gcuacauggg uucgugagag                                                   20


<210>  23038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23038
uuguccuuuc uauccgggug                                                   20


<210>  23039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23039
uuucuauccg ggugccugag                                                   20


<210>  23040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23040
auucagggug gauuucucug                                                   20


<210>  23041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23041
aaaccgaggc cccgguccau                                                   20


<210>  23042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23042
gaguguugag gcugcugggg                                                   20


<210>  23043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23043
ugaggucacu cagcgaagug                                                   20


<210>  23044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23044
cucagcgaag ugagggcaga                                                   20


<210>  23045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23045
ucccgauucu gcccucacuu                                                   20


<210>  23046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23046
ccucacucua ccaguguccu                                                   20


<210>  23047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23047
uccccugugc accacggccu                                                   20


<210>  23048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23048
ugcaggaaga ccccaagguc                                                   20


<210>  23049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23049
uccugcagga cucugcgagg                                                   20


<210>  23050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23050
uguggcuuuc cgcucuugcg                                                   20


<210>  23051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23051
ugugggguuu uucacugccc                                                   20


<210>  23052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23052
ugccaucuau cccagggcag                                                   20


<210>  23053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23053
cgucuugcca ucuaucccag                                                   20


<210>  23054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23054
ggagggagcc ccuucaggag                                                   20


<210>  23055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23055
agggaaggcu ccaccuccug                                                   20


<210>  23056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23056
cauucacaag ggaaauggug                                                   20


<210>  23057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23057
accaguuuga aguguguaau                                                   20


<210>  23058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23058
ugcaaccauc accaccaucu                                                   20


<210>  23059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23059
caaaaaaaaa aaaaaguugu                                                   20


<210>  23060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23060
cacucagucg cccaggcuag                                                   20


<210>  23061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23061
cccaggcuag aaugcagugg                                                   20


<210>  23062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23062
accucccagg cacaagcgau                                                   20


<210>  23063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23063
cuacuaaaaa uacaaaaauu                                                   20


<210>  23064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23064
aggcuggucu caaacuccug                                                   20


<210>  23065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23065
caaacuccug aucucaggug                                                   20


<210>  23066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23066
auguugucac acacguugaa                                                   20


<210>  23067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23067
cacacguuga auguauacug                                                   20


<210>  23068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23068
auaaugaaaa guauacguuu                                                   20


<210>  23069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23069
cgauuggugg ggacuuggcu                                                   20


<210>  23070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23070
ccaccaaucg ggacuaaacg                                                   20


<210>  23071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23071
gaucuaugaa augauucagg                                                   20


<210>  23072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23072
cugaaucauu ucauagauca                                                   20


<210>  23073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23073
aaugggagga ggucgaucaa                                                   20


<210>  23074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23074
aucaaagaau caagaaugau                                                   20


<210>  23075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23075
ggcucuguag aggcugggaa                                                   20


<210>  23076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23076
gucaucuuca gcaaguccug                                                   20


<210>  23077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23077
ucuucagcaa guccugguca                                                   20


<210>  23078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23078
uggucaccca ccucccaggc                                                   20


<210>  23079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23079
cccaccuccc aggcccugcc                                                   20


<210>  23080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23080
ucccuacugg gcugcagggg                                                   20


<210>  23081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23081
accugugucu uggcccagca                                                   20


<210>  23082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23082
uggcccagca gggaggacac                                                   20


<210>  23083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23083
ucccugcugg gccaagacac                                                   20


<210>  23084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23084
accugucucc uggcccagca                                                   20


<210>  23085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23085
ccuggcccag cagggaggac                                                   20


<210>  23086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23086
ucccugcugg gccaggagac                                                   20


<210>  23087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23087
accugccucc uggcccagca                                                   20


<210>  23088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23088
ucccugcugg gccaggaggc                                                   20


<210>  23089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23089
accugucucu uggcccagca                                                   20


<210>  23090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23090
cuuggcccag cagggaggac                                                   20


<210>  23091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23091
ucccugcugg gccaagagac                                                   20


<210>  23092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23092
accugccucc uuccccaugc                                                   20


<210>  23093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23093
gaugaaaucc caguggcagg                                                   20


<210>  23094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23094
ggaaacuuuu cucacuggcu                                                   20


<210>  23095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23095
uuuccagauc augucuggaa                                                   20


<210>  23096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23096
augaaacaag gcuuggcuau                                                   20


<210>  23097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23097
aacuucauau aaaauugguc                                                   20


<210>  23098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23098
cagagacacu cugaccugag                                                   20


<210>  23099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23099
cugggacuac aaucccuggc                                                   20


<210>  23100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23100
gagugucucu gggacuacaa                                                   20


<210>  23101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23101
agcaccaggc ccagagccag                                                   20


<210>  23102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23102
guccagcacc aggcccagag                                                   20


<210>  23103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23103
gccucagagg cccuuagcac                                                   20


<210>  23104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23104
cagcaaggag augagcccca                                                   20


<210>  23105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23105
ccaccgcuug gggcucaucu                                                   20


<210>  23106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23106
cuggucccag aaugagccag                                                   20


<210>  23107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23107
cagaaugagc caguggcugu                                                   20


<210>  23108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23108
ggguccaucu gccucuggga                                                   20


<210>  23109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23109
aucugccucu gggacuggac                                                   20


<210>  23110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23110
cagaggcaga uggacccuga                                                   20


<210>  23111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23111
agucccagag gcagauggac                                                   20


<210>  23112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23112
gggcagugag gggugguaac                                                   20


<210>  23113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23113
uaggcauugg gggaaacagc                                                   20


<210>  23114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23114
ccgcccugcc agcgagaacu                                                   20


<210>  23115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23115
guucucgcug gcagggcggg                                                   20


<210>  23116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23116
augcauuugu ucuguuuccu                                                   20


<210>  23117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23117
uccccacagc ccacacgucu                                                   20


<210>  23118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23118
uccagagugc ggguccuccc                                                   20


<210>  23119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23119
gccugcuggg cagagcagac                                                   20


<210>  23120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23120
gcucugccca gcaggccgac                                                   20


<210>  23121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23121
gcaauagcaa ggccacagug                                                   20


<210>  23122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23122
cccucuaacc cccuccugcu                                                   20


<210>  23123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23123
cgucccccuc uaacccccuc                                                   20


<210>  23124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23124
cuuguuauug ucaucauugu                                                   20


<210>  23125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23125
ucauugucaa gccuugagug                                                   20


<210>  23126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23126
agccuugagu guugcuuccu                                                   20


<210>  23127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23127
caucacauca cucuucacag                                                   20


<210>  23128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23128
auucauucuc ucccaguggc                                                   20


<210>  23129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23129
ccuuuacucu caccugaauc                                                   20


<210>  23130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23130
gcgucaccuu uacucucacc                                                   20


<210>  23131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23131
ucugccauca cuucucacac                                                   20


<210>  23132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23132
gauucaggau ggauccugaa                                                   20


<210>  23133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23133
ucuccaccac cugccuucag                                                   20


<210>  23134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23134
gccugaaguc uucuccacca                                                   20


<210>  23135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23135
uugcaguggg gaggacagca                                                   20


<210>  23136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23136
uccccacugc aaggacuugg                                                   20


<210>  23137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23137
cuggaggaac ugcccacaca                                                   20


<210>  23138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23138
guggccagug cagcacagcu                                                   20


<210>  23139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23139
ccccagcugu gcugcacugg                                                   20


<210>  23140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23140
cuuauggagc uucuuuuucu                                                   20


<210>  23141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23141
gccccuagug gggagcaaag                                                   20


<210>  23142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23142
gcaugggcuc uugaugcugu                                                   20


<210>  23143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23143
agguguggca gaagcccagc                                                   20


<210>  23144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23144
agcagcuaga gagaggccgg                                                   20


<210>  23145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23145
cucccuggca ugcagcccag                                                   20


<210>  23146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23146
ucuagucacu cccuggcaug                                                   20


<210>  23147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23147
guccucuagu cacucccugg                                                   20


<210>  23148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23148
agcccauggu cuguccucua                                                   20


<210>  23149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23149
acuggagcca gcgucgagcc                                                   20


<210>  23150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23150
auuuccucgu ccacuggagc                                                   20


<210>  23151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23151
aaguugggag uccauacacc                                                   20


<210>  23152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23152
auacaccucc aggccagagu                                                   20


<210>  23153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23153
cucucaucuu ucuaacucug                                                   20


<210>  23154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23154
gcuccacucc aagcagcuuc                                                   20


<210>  23155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23155
ggggugugac cagggagaga                                                   20


<210>  23156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23156
caccccagac ucuuggccag                                                   20


<210>  23157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23157
cuggggggau ggaggaugaa                                                   20


<210>  23158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23158
cuggagaaga gaaggccaca                                                   20


<210>  23159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23159
uguggccuuc ucuucuccag                                                   20


<210>  23160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23160
guuacccagg cacagcugcu                                                   20


<210>  23161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23161
uuuucaugug uuuccauaua                                                   20


<210>  23162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23162
uggagccagg ggucagccug                                                   20


<210>  23163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23163
gccuggaguu cucccggcua                                                   20


<210>  23164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23164
gcucuaagca gagugaggua                                                   20


<210>  23165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23165
uccucccaca ggacacugac                                                   20


<210>  23166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23166
ugugggagga agacuccauu                                                   20


<210>  23167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23167
guguccugug ggaggaagac                                                   20


<210>  23168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23168
gccccuaaga gcucacaguu                                                   20


<210>  23169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23169
uuucuguuug uuuuaggccu                                                   20


<210>  23170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23170
aggcaggugg aucaugaggu                                                   20


<210>  23171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23171
ggaguuugag accagccugg                                                   20


<210>  23172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23172
caaacuccug accucaugau                                                   20


<210>  23173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23173
ccaggcugga gugcaguggc                                                   20


<210>  23174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23174
ugcucugucg ccaggcugga                                                   20


<210>  23175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23175
caaaaaagaa aaaagaaaag                                                   20


<210>  23176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23176
uaaguggaua gaaacaaagg                                                   20


<210>  23177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23177
gagugagggc ucugugugag                                                   20


<210>  23178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23178
cagcucccau uacaggauca                                                   20


<210>  23179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23179
uuaacccaua gaacccauuc                                                   20


<210>  23180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23180
cacagcaacu gcuggcagcu                                                   20


<210>  23181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23181
agcugccagc aguugcugug                                                   20


<210>  23182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23182
aaaagcuggc cucaggucca                                                   20


<210>  23183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23183
ggccaucugu cuuagucccu                                                   20


<210>  23184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23184
uagucccuuu gggcugcuau                                                   20


<210>  23185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23185
cuuugggcug cuaugacaga                                                   20


<210>  23186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23186
uagcagccca aagggacuaa                                                   20


<210>  23187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23187
aagggauucu gucauagcag                                                   20


<210>  23188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23188
ggaggcugga aguccuagau                                                   20


<210>  23189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23189
uagaucaaga ugccugcaga                                                   20


<210>  23190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23190
cuagcuccuu ggcucaagug                                                   20


<210>  23191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23191
auauuuuaaa agaaagaaag                                                   20


<210>  23192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23192
ucugcccugu gagggugcag                                                   20


<210>  23193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23193
ugaaggcucu gcccucguga                                                   20


<210>  23194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23194
caccucucaa uacuauugca                                                   20


<210>  23195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23195
cugagaugca gaaaugguau                                                   20


<210>  23196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23196
caaagaaaca acaacaaaua                                                   20


<210>  23197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23197
caagaaacag aucuggccca                                                   20


<210>  23198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23198
caccacugua cuccaaccug                                                   20


<210>  23199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23199
cagcuacuca ggagccugag                                                   20


<210>  23200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23200
ggcuaauuuu uguauuuuua                                                   20


<210>  23201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23201
cuacuaaaaa uacaaaaauu                                                   20


<210>  23202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23202
ugaucuccug accucgugau                                                   20


<210>  23203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23203
ggagaucaag accauccugg                                                   20


<210>  23204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23204
ucacauccgu uuuaaauuaa                                                   20


<210>  23205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23205
cacagccuua gcuucaggaa                                                   20


<210>  23206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23206
agcaggacag ccuggcaaua                                                   20


<210>  23207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23207
ugcuagacuc aaagcuuccu                                                   20


<210>  23208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23208
aaaugacuca uucucagcaa                                                   20


<210>  23209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23209
uuuggacgcg ccauuauugc                                                   20


<210>  23210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23210
ucgaggagag guggaggauc                                                   20


<210>  23211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23211
gcaagccgaa gagcuuugua                                                   20


<210>  23212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23212
acaaagcucu ucggcuugcu                                                   20


<210>  23213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23213
gcgcuucuau cucccaccgc                                                   20


<210>  23214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23214
uugggacuuu gaguuggcca                                                   20


<210>  23215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23215
caaagaccag aaagcauucu                                                   20


<210>  23216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23216
agacuuugca ggucuauuac                                                   20


<210>  23217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23217
agacgcuguu uaccaucugg                                                   20


<210>  23218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23218
auuacagcga uucaacucug                                                   20


<210>  23219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23219
auaaagccuu guuuccaaaa                                                   20


<210>  23220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23220
agccaccaca ggcaccagcu                                                   20


<210>  23221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23221
aggucacguu ucaggggucc                                                   20


<210>  23222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23222
cguuucaggg guccaggucu                                                   20


<210>  23223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23223
aggucuuuca uguguugcuu                                                   20


<210>  23224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23224
uucauguguu gcuuuugagc                                                   20


<210>  23225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23225
uuagugguau uucugaaauu                                                   20


<210>  23226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23226
auuucagaaa uaccacuaag                                                   20


<210>  23227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23227
gcuauguuau uccuuaaguu                                                   20


<210>  23228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23228
uauaauuuaa ugaguaaagu                                                   20


<210>  23229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23229
gaguuccuga ggucugcuug                                                   20


<210>  23230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23230
gcuugaugcu uggaaauuau                                                   20


<210>  23231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23231
ugagccaccg cgcccagcug                                                   20


<210>  23232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23232
aggcgggugg aucacgaggu                                                   20


<210>  23233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23233
ggagauggag accacgguga                                                   20


<210>  23234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23234
ccaucuccug accucgugau                                                   20


<210>  23235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23235
ccacuaaaaa uacaaaaaau                                                   20


<210>  23236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23236
cagcuacucg ggaggcugag                                                   20


<210>  23237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23237
cccaggcugg agugcagugg                                                   20


<210>  23238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23238
cguucuguca cccaggcugg                                                   20


<210>  23239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23239
uuugguuauu auuaugcagg                                                   20


<210>  23240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23240
uugaacacgg ggugcugcuu                                                   20


<210>  23241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23241
ugauguaagu gcauugccag                                                   20


<210>  23242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23242
uggcaaugca cuuacaucag                                                   20


<210>  23243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23243
cacuguguug cccaggcugg                                                   20


<210>  23244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23244
ugcacuccug gccucaagug                                                   20


<210>  23245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23245
uccaccuugg ccucccacag                                                   20


<210>  23246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23246
uaccugguuc uucuucccuc                                                   20


<210>  23247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23247
ccccagugug cuuuggccac                                                   20


<210>  23248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23248
gugaggggcc cagugagugg                                                   20


<210>  23249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23249
cugucagccu cacugcuggg                                                   20


<210>  23250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23250
gccucacugc ugggggagcc                                                   20


<210>  23251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23251
cagcuaccug gggggcuccc                                                   20


<210>  23252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23252
cuagaaaaga agugaaaaug                                                   20


<210>  23253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23253
cccuauguug cccaggcuac                                                   20


<210>  23254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23254
aggcaggagg aucacuuggg                                                   20


<210>  23255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23255
ccuuucuggu cucagggcug                                                   20


<210>  23256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23256
cagggcuggc uuucucucuc                                                   20


<210>  23257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23257
ggaacgcgug uccccacucu                                                   20


<210>  23258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23258
ccacucugcu ucucaugagg                                                   20


<210>  23259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23259
ugggacugug gccuggcccc                                                   20


<210>  23260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23260
caggaccuca ugagaagcag                                                   20


<210>  23261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23261
ucaguacggg gccaggccac                                                   20


<210>  23262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23262
cugugccucc uugugagugu                                                   20


<210>  23263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23263
caacagcaca cucacaagga                                                   20


<210>  23264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23264
agaggaaggu gucccaacag                                                   20


<210>  23265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23265
ccgaggggcg gggccugccg                                                   20


<210>  23266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23266
acuuccgccu ccccaccuug                                                   20


<210>  23267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23267
gcacagcugu uagaguagcu                                                   20


<210>  23268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23268
ugggugaaaa guuucucagg                                                   20


<210>  23269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23269
ugagaaacuu uucacccagg                                                   20


<210>  23270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23270
cacagcugcc gacuuccgug                                                   20


<210>  23271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23271
gcagcugugg gacccucauc                                                   20


<210>  23272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23272
ccaccugccg ccaguacagu                                                   20


<210>  23273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23273
gggucuccac cugccgccag                                                   20


<210>  23274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23274
ggcaggcagg agggagugcc                                                   20


<210>  23275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23275
ucagaggcag agggucaggc                                                   20


<210>  23276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23276
gcagcuccua ucccggcacu                                                   20


<210>  23277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23277
cagaggaggg accugcugau                                                   20


<210>  23278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23278
cuccucuggg acaggaaccc                                                   20


<210>  23279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23279
cuugcagccu uggagaccac                                                   20


<210>  23280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23280
ccaaggcugc aagggaccuc                                                   20


<210>  23281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23281
acugaguggu cuccaaggcu                                                   20


<210>  23282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23282
cuaagggauc ccaccgcugg                                                   20


<210>  23283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23283
cuguucacac uucuccgguu                                                   20


<210>  23284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23284
acccugcccu gcaucccuga                                                   20


<210>  23285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23285
gggaugcagg gcagggugga                                                   20


<210>  23286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23286
cuugcaugcc cuggcucucu                                                   20


<210>  23287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23287
gugccagguc ccuugcaugc                                                   20


<210>  23288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23288
ccaauuuugu gguacugucu                                                   20


<210>  23289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23289
ucugaagagg ugguucgcca                                                   20


<210>  23290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23290
ccauucuuuu gccaggcccc                                                   20


<210>  23291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23291
guuugcuggg cguuucauuc                                                   20


<210>  23292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23292
ucucagaggc ugccccuguu                                                   20


<210>  23293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23293
uuacaguaaa cggcaugagg                                                   20


<210>  23294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23294
uggauaucga gcaguucucg                                                   20


<210>  23295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23295
agguagaucc cuuucaccac                                                   20


<210>  23296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23296
ucaucugcgg uguccaggua                                                   20


<210>  23297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23297
ccauccccug gcagaaugag                                                   20


<210>  23298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23298
cuguuggaac uaacguaaag                                                   20


<210>  23299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23299
gugugugugu gugugucugu                                                   20


<210>  23300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23300
guguguauuu gggagauaaa                                                   20


<210>  23301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23301
uauauaauuu uaucucccaa                                                   20


<210>  23302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23302
ggaguucgag accagccugg                                                   20


<210>  23303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23303
cgaacuccug accucaugau                                                   20


<210>  23304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23304
cuacuaaaag uacaaaaauu                                                   20


<210>  23305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23305
cagcuaguag ggaugcugag                                                   20


<210>  23306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23306
cccaaggugg aguacagugg                                                   20


<210>  23307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23307
cguucugucg cccaaggugg                                                   20


<210>  23308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23308
cacccaaaaa aaaaaaaaaa                                                   20


<210>  23309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23309
uauacaaucu uuuuuuuuuu                                                   20


<210>  23310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23310
aaagucuuau acaaucuuuu                                                   20


<210>  23311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23311
uguggucaaa agucuuauac                                                   20


<210>  23312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23312
aguccugugg ucaaaagucu                                                   20


<210>  23313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23313
uuggcuugcc cauggucuag                                                   20


<210>  23314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23314
agaagcacag cggcuguccc                                                   20


<210>  23315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23315
cuggucccaa ugacaggaag                                                   20


<210>  23316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23316
caaugacagg aaguggacag                                                   20


<210>  23317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23317
uugggaccag ggacagccgc                                                   20


<210>  23318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23318
acuuccuguc auugggacca                                                   20


<210>  23319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23319
gaugggagcu ugccugccac                                                   20


<210>  23320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23320
cugaguguac ucccaaagca                                                   20


<210>  23321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23321
ccucuccccu ugucucugag                                                   20


<210>  23322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23322
ggaagcaggg aaggaggaac                                                   20


<210>  23323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23323
cccagugcca gcagcuccug                                                   20


<210>  23324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23324
gugggugucu cccagugcca                                                   20


<210>  23325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23325
uguuauucug ugcaugcaga                                                   20


<210>  23326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23326
uugaaacacc cagauucgau                                                   20


<210>  23327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23327
agaucuaaug gcaaagcuuc                                                   20


<210>  23328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23328
ggaaaccggg guauguaugu                                                   20


<210>  23329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23329
auagaagaag ccucuguuug                                                   20


<210>  23330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23330
uuuuaccccu cuucugaaga                                                   20


<210>  23331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23331
guauguuuuu uuuuuuuuca                                                   20


<210>  23332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23332
gagagccaca uggugcuagg                                                   20


<210>  23333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23333
ucaucccagc aacaaaccuc                                                   20


<210>  23334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23334
uguuuuggau cagaacaguc                                                   20


<210>  23335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23335
cugacaaaau aguuuacacu                                                   20


<210>  23336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23336
gcgacacggg aaccuguuug                                                   20


<210>  23337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23337
gauggcacuc acagugcauc                                                   20


<210>  23338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23338
aagagccaga gcagggagag                                                   20


<210>  23339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23339
ggaguuugag accagccugg                                                   20


<210>  23340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23340
caaacuccug accucaggug                                                   20


<210>  23341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23341
cagcuacuug ggaggcugag                                                   20


<210>  23342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23342
ugcgcuguug cccaggcugg                                                   20


<210>  23343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23343
uuccaaagga uuccauuuuu                                                   20


<210>  23344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23344
acauuuaaug cuauuacaga                                                   20


<210>  23345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23345
cuccuuggau ucgugggcca                                                   20


<210>  23346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23346
ggaguucaag accagcuuag                                                   20


<210>  23347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23347
ugaacuccug accucaggug                                                   20


<210>  23348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23348
ugguggcaug ugccuguaau                                                   20


<210>  23349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23349
gaggcaggag aaucgcuuga                                                   20


<210>  23350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23350
cggcucccug uaaccuccgc                                                   20


<210>  23351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23351
cccaggcugg agcgcaaugg                                                   20


<210>  23352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23352
uaaaaaaaaa aaaaaaaaaa                                                   20


<210>  23353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23353
uuccucugag aacuaagggu                                                   20


<210>  23354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23354
gggagagcca uuuuguuagu                                                   20


<210>  23355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23355
caguguccac acuuggagau                                                   20


<210>  23356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23356
acacuuggag auggaaccca                                                   20


<210>  23357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23357
cuggcugccu aagaagcagu                                                   20


<210>  23358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23358
cagggucucu ggcugccuaa                                                   20


<210>  23359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23359
cugcuaaaaa uacaaaacuu                                                   20


<210>  23360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23360
uagcuacuca ggaggcugag                                                   20


<210>  23361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23361
cccaggcugg agugcaaugg                                                   20


<210>  23362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23362
cacucugucg cccaggcugg                                                   20


<210>  23363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23363
caaaaaauaa auaaauaaau                                                   20


<210>  23364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23364
gcacuuaagg aaagugaaac                                                   20


<210>  23365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23365
ggcagcccua caacacacag                                                   20


<210>  23366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23366
ccagugagaa ggaaguggaa                                                   20


<210>  23367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23367
gcaccggggu gcucagcauu                                                   20


<210>  23368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23368
gcucuguggu ccgcaccggg                                                   20


<210>  23369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23369
cgucccaccu ggaauuguaa                                                   20


<210>  23370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23370
caccuggaau uguaauaaau                                                   20


<210>  23371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23371
guacacuccc aaggcauguu                                                   20


<210>  23372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23372
uuucacuaaa gcuggauuga                                                   20


<210>  23373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23373
ggggccucag ggguacucuu                                                   20


<210>  23374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23374
uccauuccca agcccccgcu                                                   20


<210>  23375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23375
ggggguggcg cgaggcacug                                                   20


<210>  23376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23376
caccacucgg ccagagaugu                                                   20


<210>  23377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23377
aggaagagag ggggcggccg                                                   20


<210>  23378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23378
gacaguccga gcccguuggc                                                   20


<210>  23379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23379
gacacccggg cccuggggaa                                                   20


<210>  23380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23380
gagcccguug gcauuccugc                                                   20


<210>  23381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23381
cguugccuug ugccccucac                                                   20


<210>  23382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23382
uggggagccg ccccuuucaa                                                   20


<210>  23383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23383
gggccuggcg gccagggcuc                                                   20


<210>  23384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23384
ccgcaugccg ggcgcaccug                                                   20


<210>  23385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23385
acgucagggc ccccgagagg                                                   20


<210>  23386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23386
gggcccccga gaggccggua                                                   20


<210>  23387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23387
gggaugagga gcccgcccuc                                                   20


<210>  23388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23388
ccccgcgggu gagcacccca                                                   20


<210>  23389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23389
acacccuucc gcuacgcccu                                                   20


<210>  23390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23390
cccccuggga aaucuucaug                                                   20


<210>  23391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23391
cuccuguucg cuccccgccc                                                   20


<210>  23392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23392
gcucuggggc cucagcccuc                                                   20


<210>  23393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23393
agugcugccc ugcccugcgg                                                   20


<210>  23394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23394
gcuccucccu gaaccagccc                                                   20


<210>  23395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23395
ccgucagcuc cucccugaac                                                   20


<210>  23396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23396
gggcugccug gagccugcag                                                   20


<210>  23397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23397
ccgaggccug ugcccuggcu                                                   20


<210>  23398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23398
gguucaaagu caccgaggcc                                                   20


<210>  23399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23399
cugucugguu caaagucacc                                                   20


<210>  23400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23400
gaugugucac ugucugguuc                                                   20


<210>  23401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23401
cucaggcacu gugguuccuc                                                   20


<210>  23402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23402
cuccugcugc ucuugugaaa                                                   20


<210>  23403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23403
gccuggaagc cuggucgcuc                                                   20


<210>  23404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23404
ugggaggaaa acaccagcgg                                                   20


<210>  23405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23405
ccaugagguu gggagccuuc                                                   20


<210>  23406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23406
ccuuccccuu ccccucguac                                                   20


<210>  23407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23407
ccaagauaac guccccuucc                                                   20


<210>  23408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23408
uuauucuuug ggggaaugga                                                   20


<210>  23409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23409
cccgcuucca aaaagccuua                                                   20


<210>  23410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23410
cgccgcgguc acccgcuucc                                                   20


<210>  23411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23411
agagucccgc cgcggucacc                                                   20


<210>  23412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23412
ucagcugcag aaugaagaug                                                   20


<210>  23413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23413
guaaaucaug uagcacagug                                                   20


<210>  23414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23414
ccauucagua acuaugccaa                                                   20


<210>  23415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23415
gaguggaaau gggggugggg                                                   20


<210>  23416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23416
acacugaugg aagaacuccu                                                   20


<210>  23417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23417
acagcggaau cacaguguag                                                   20


<210>  23418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23418
acacugugau uccgcugugg                                                   20


<210>  23419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23419
ucuacacugu gauuccgcug                                                   20


<210>  23420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23420
ccagccccca gcagagucgu                                                   20


<210>  23421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23421
ucagcccagc caggucccca                                                   20


<210>  23422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23422
gguccucagc ccagccaggu                                                   20


<210>  23423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23423
cuaaacuuca acaccugcgc                                                   20


<210>  23424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23424
gaggcauuug aacaagagca                                                   20


<210>  23425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23425
caggcucauu uuacccagcc                                                   20


<210>  23426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23426
caaagagcuu gcugauaaaa                                                   20


<210>  23427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23427
guuuuaucag caagcucuuu                                                   20


<210>  23428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23428
cuaacuccug gccucaagug                                                   20


<210>  23429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23429
cuaauacaaa aauuagccag                                                   20


<210>  23430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23430
cagcuacucg ggaggcugag                                                   20


<210>  23431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23431
gaggcugcag ugagccgaga                                                   20


<210>  23432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23432
cggcucacug cagccucuga                                                   20


<210>  23433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23433
ugcucuguug cccaggucuc                                                   20


<210>  23434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23434
caaaaaaaau aauaaaauaa                                                   20


<210>  23435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23435
cucucaucgc caucuugguu                                                   20


<210>  23436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23436
uccucacagc ucauuacaug                                                   20


<210>  23437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23437
uuuggcaugu uaaugcauua                                                   20


<210>  23438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23438
uggcgcugau gggagugucu                                                   20


<210>  23439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23439
gaaagcuacc cuguauguuc                                                   20


<210>  23440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23440
ggaucgggac cccuguccag                                                   20


<210>  23441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23441
cgauccagac cccaaaagag                                                   20


<210>  23442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23442
aguagcacuc ccuccaucuu                                                   20


<210>  23443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23443
aguuuccucc ucagcaggca                                                   20


<210>  23444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23444
guucccaggu cuaguuuccu                                                   20


<210>  23445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23445
uuuuuguuuc uuuguuucuu                                                   20


<210>  23446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23446
gaguuaaauu uccccaugcc                                                   20


<210>  23447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23447
aagcuuucac uugggcaugg                                                   20


<210>  23448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23448
guguacaaau ccuggccuag                                                   20


<210>  23449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23449
uugugcaggg gcaaugcuaa                                                   20


<210>  23450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23450
uccuugugca ggggcaaugc                                                   20


<210>  23451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23451
uuaauauuag cugcugugca                                                   20


<210>  23452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23452
uuuggcugcu uaaauuuuua                                                   20


<210>  23453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23453
cgcucuguug cccaggcugg                                                   20


<210>  23454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23454
acauggugaa accccaucug                                                   20


<210>  23455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23455
cgaaccccug gccuuaagua                                                   20


<210>  23456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23456
uccaugauau ugugaaguua                                                   20


<210>  23457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23457
ccuggcauau auuuccccaa                                                   20


<210>  23458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23458
uuuuuguaug uuaaugaggu                                                   20


<210>  23459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23459
aggagccacc agccaccuca                                                   20


<210>  23460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23460
ccagaaagaa gaagguaggg                                                   20


<210>  23461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23461
caaccuucua acccuaccuu                                                   20


<210>  23462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23462
ucuuggguuu uuauggaggc                                                   20


<210>  23463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23463
ccguagaagg gaggugcgcu                                                   20


<210>  23464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23464
caagcacagg agcuucuguc                                                   20


<210>  23465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23465
gucagaauca caggccaaau                                                   20


<210>  23466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23466
gaaucacagg ccaaauaacc                                                   20


<210>  23467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23467
ugugggaacu gaguccucga                                                   20


<210>  23468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23468
ucgaucugug uggucaggcg                                                   20


<210>  23469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23469
ggcgcugucu acagguagau                                                   20


<210>  23470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23470
acagguagau gccgucagac                                                   20


<210>  23471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23471
gacuugaaug agaggacacc                                                   20


<210>  23472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23472
gacggcaucu accuguagac                                                   20


<210>  23473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23473
ucucauucaa gucugacggc                                                   20


<210>  23474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23474
gcugcagaac ugauugcuug                                                   20


<210>  23475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23475
uuuuccuguu cucucacuca                                                   20


<210>  23476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23476
cguguucaaa aaauguuggg                                                   20


<210>  23477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23477
gagggaggaa aaccacaucc                                                   20


<210>  23478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23478
aaaggugaag cagaggacac                                                   20


<210>  23479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23479
ucugcuucac cuuuugacgu                                                   20


<210>  23480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23480
ccagaggcgg ugcagugagg                                                   20


<210>  23481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23481
cuuaccagga agggaagcau                                                   20


<210>  23482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23482
guucuuuuuu ucuagagcug                                                   20


<210>  23483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23483
gaccuguccu gucacggcca                                                   20


<210>  23484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23484
gacucgccuc agugugcccc                                                   20


<210>  23485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23485
ugucacggcc aggaacucag                                                   20


<210>  23486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23486
cggccaggaa cucaguuuuu                                                   20


<210>  23487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23487
ccucgaccaa gaagcggucc                                                   20


<210>  23488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23488
aggagaccuc agagaaaccu                                                   20


<210>  23489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23489
gcucaguugg cagggguuuu                                                   20


<210>  23490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23490
cucugaaucu gcugugauuc                                                   20


<210>  23491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23491
gaacaaaucu auagacaaaa                                                   20


<210>  23492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23492
auagauuugu ucugaccacg                                                   20


<210>  23493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23493
cuucccuuuu uugucuauag                                                   20


<210>  23494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23494
aaauaaggca aaugccgagc                                                   20


<210>  23495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23495
uggccaaucc cagcagccgu                                                   20


<210>  23496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23496
gcaccugugg caguaccuga                                                   20


<210>  23497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23497
ggguuucagu cuugucuacc                                                   20


<210>  23498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23498
ugucuaccaa uuaaguuagg                                                   20


<210>  23499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23499
accaauuaag uuagguugca                                                   20


<210>  23500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23500
acaaggacuc aaauagagaa                                                   20


<210>  23501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23501
uuguggacga acugcaaccu                                                   20


<210>  23502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23502
uucucaggcc auauuuaguu                                                   20


<210>  23503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23503
uuuucucaau uuugagagau                                                   20


<210>  23504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23504
aucucucaaa auugagaaaa                                                   20


<210>  23505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23505
uugaugucac uaucaccauc                                                   20


<210>  23506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23506
cuaucaccau cguaaaugua                                                   20


<210>  23507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23507
ugaaacccuc ugagaaacag                                                   20


<210>  23508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23508
uuguuccuac cuuugcaaaa                                                   20


<210>  23509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23509
uguuuauagg ggaaucuguu                                                   20


<210>  23510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23510
uaguuugauu augucacauu                                                   20


<210>  23511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23511
cauuuagcau gagugacucc                                                   20


<210>  23512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23512
cucaugcuaa augugacaua                                                   20


<210>  23513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23513
guugggacau agugcaugag                                                   20


<210>  23514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23514
caacagacua agccaaacaa                                                   20


<210>  23515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23515
aaaacaaugg ccucccauaa                                                   20


<210>  23516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23516
agguucucac uuaggugagu                                                   20


<210>  23517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23517
ugccuuggca gcuggguggc                                                   20


<210>  23518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23518
ggagaucgag accauccugg                                                   20


<210>  23519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23519
cgaucuccug accucaugau                                                   20


<210>  23520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23520
cuacuaaaaa uacaaaaaau                                                   20


<210>  23521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23521
cagcuacucg ggaggcugag                                                   20


<210>  23522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23522
cccaggcugg agggcagugg                                                   20


<210>  23523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23523
cgcucuguca cccaggcugg                                                   20


<210>  23524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23524
caaaaaacaa aaacaaaaac                                                   20


<210>  23525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23525
uaucuaauca uaucuauaau                                                   20


<210>  23526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23526
cuucagcucc uaucucugua                                                   20


<210>  23527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23527
cuucucaccc ugucccuuca                                                   20


<210>  23528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23528
ucuggucacu ucucacccug                                                   20


<210>  23529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23529
cgcucagaca gggccacuag                                                   20


<210>  23530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23530
gagcgugaca gagggcucac                                                   20


<210>  23531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23531
agugguaaug acagugccug                                                   20


<210>  23532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23532
uuaccacuag accagggagc                                                   20


<210>  23533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23533
gcuaaguaac aggugccuuc                                                   20


<210>  23534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23534
cccuuuggcc aggggagagg                                                   20


<210>  23535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23535
ucucuaaccc cuccgccccu                                                   20


<210>  23536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23536
ggccuuccac aagagauggu                                                   20


<210>  23537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23537
ggcccgccca cagccauccg                                                   20


<210>  23538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23538
ggccuccgga uggcuguggg                                                   20


<210>  23539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23539
cgcuccuguu ucacuuucau                                                   20


<210>  23540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23540
uugaaaugca uagaagaaau                                                   20


<210>  23541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23541
uuauuucuuc uaugcauuuc                                                   20


<210>  23542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23542
ccucucucuc uccgccucgg                                                   20


<210>  23543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23543
gguggacacg ugacuugcgu                                                   20


<210>  23544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23544
accggacagg gugcccuucc                                                   20


<210>  23545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23545
cguguccacc ggacagggug                                                   20


<210>  23546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23546
cgcaagucac guguccaccg                                                   20


<210>  23547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23547
ggucacgcaa gucacguguc                                                   20


<210>  23548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23548
ucuccaauga uaggucaggu                                                   20


<210>  23549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23549
uguauccaau aaguaacagg                                                   20


<210>  23550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23550
ccgugucuag gugguagugg                                                   20


<210>  23551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23551
aggugguagu gguccccugg                                                   20


<210>  23552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23552
ccugggccca gcugucuuuu                                                   20


<210>  23553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23553
uuucuucuau cucuuugucu                                                   20


<210>  23554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23554
uguguccuua uuucugugau                                                   20


<210>  23555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23555
uuauuucugu gaucucucau                                                   20


<210>  23556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23556
agcccuacug ggccuguggg                                                   20


<210>  23557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23557
cacucucgcc uguagggucc                                                   20


<210>  23558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23558
cagcacguca uucauagguu                                                   20


<210>  23559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23559
uucauagguu acgguguccu                                                   20


<210>  23560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23560
ucauggucac acauuucuuu                                                   20


<210>  23561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23561
cacauuucuu ucagcuucug                                                   20


<210>  23562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23562
cucuucaacu ggaauggcag                                                   20


<210>  23563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23563
gcaugcagcc aucucuagaa                                                   20


<210>  23564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23564
cccuggugcg cugcauucuc                                                   20


<210>  23565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23565
cuauacacca aaccacccca                                                   20


<210>  23566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23566
gaucuauuug auuuggggug                                                   20


<210>  23567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23567
auucuauuau uuagcauacc                                                   20


<210>  23568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23568
guuguguaac uauagccuuu                                                   20


<210>  23569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23569
gcuauacagc cuaucaugag                                                   20


<210>  23570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23570
gaaacagaau aucgguucac                                                   20


<210>  23571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23571
cauuaaaguu ucucaccuac                                                   20


<210>  23572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23572
aguguaggug agaaacuuua                                                   20


<210>  23573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23573
uuucauuucu auuauucaua                                                   20


<210>  23574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23574
cauggccagg cgugguggug                                                   20


<210>  23575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23575
cagcucacug caaccucugc                                                   20


<210>  23576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23576
cccaggcugg agugcggugg                                                   20


<210>  23577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23577
ugcucuguca cccaggcugg                                                   20


<210>  23578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23578
caugacagua gaagucuuga                                                   20


<210>  23579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23579
ugagacucuc uuuuuuuuuu                                                   20


<210>  23580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23580
ugauccacga ucuuagcaaa                                                   20


<210>  23581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23581
cuccccagaa gauggcaucc                                                   20


<210>  23582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23582
auccacacuc cuggaacugu                                                   20


<210>  23583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23583
uugccauccg cacugcaaca                                                   20


<210>  23584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23584
uucucugaug uucucagaag                                                   20


<210>  23585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23585
ucggguucua gaaugcaaag                                                   20


<210>  23586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23586
aacccuuugc auucuagaac                                                   20


<210>  23587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23587
uuuucaaugc auguuuuccg                                                   20


<210>  23588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23588
cccaggcugg agugcagcgg                                                   20


<210>  23589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23589
cgaaaugcag aacuuuuaau                                                   20


<210>  23590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23590
uuaaagcuuu uguuauuaaa                                                   20


<210>  23591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23591
uuccugaguc cuuaaagcuu                                                   20


<210>  23592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23592
ugguucuccg ugaguccaua                                                   20


<210>  23593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23593
auacuuaauu aacauuagac                                                   20


<210>  23594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23594
aauguuaauu aaguauggac                                                   20


<210>  23595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23595
ucuugaaucc caguugcuuc                                                   20


<210>  23596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23596
aauuaccugu gauaacccau                                                   20


<210>  23597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23597
aagucaaauu accugugaua                                                   20


<210>  23598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23598
gcugauuuaa gaugaaaauc                                                   20


<210>  23599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23599
gucuuuucau uaaaguucca                                                   20


<210>  23600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23600
uuucauuaaa guuccaggaa                                                   20


<210>  23601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23601
uggaauacag guuucuaaua                                                   20


<210>  23602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23602
uuuucauccu uuuaugaauc                                                   20


<210>  23603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23603
uuuaggagau ucauaaaagg                                                   20


<210>  23604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23604
uuuccacagu uaauugcuua                                                   20


<210>  23605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23605
uaguuaaaaa cacaauugac                                                   20


<210>  23606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23606
auuguguuuu uaacuaugac                                                   20


<210>  23607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23607
augcuaucaa uauaauuaug                                                   20


<210>  23608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23608
aaaaauaaug uuuacuccuc                                                   20


<210>  23609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23609
gaaagacuau uuugaagcug                                                   20


<210>  23610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23610
uucugaccuc uaacuuuggg                                                   20


<210>  23611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23611
aacugguuaa gcauaacauc                                                   20


<210>  23612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23612
cuguacucca gccugggcaa                                                   20


<210>  23613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23613
cuacuaaaaa uacaaaauua                                                   20


<210>  23614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23614
ggcuggucuc gaacucccga                                                   20


<210>  23615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23615
cgaacucccg accucaggug                                                   20


<210>  23616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23616
ggaguucgag accagccuga                                                   20


<210>  23617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23617
cuagggcuac ucagggaaag                                                   20


<210>  23618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23618
gauuucugac cucucucucu                                                   20


<210>  23619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23619
gaaaucugac ugguaagaaa                                                   20


<210>  23620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23620
ucccgugcug uucugugaua                                                   20


<210>  23621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23621
guaacugcug cagaucccug                                                   20


<210>  23622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23622
ccaucuuguu uuaagucuuu                                                   20


<210>  23623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23623
uugggaguuu gaccuuguaa                                                   20


<210>  23624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23624
aacucccaaa gacuuaaaac                                                   20


<210>  23625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23625
ccaccuucca aguggaacag                                                   20


<210>  23626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23626
uaguuagcuc uacaaucuau                                                   20


<210>  23627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23627
agaguaguua auuuucagcu                                                   20


<210>  23628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23628
ccauugcccu ucccagaaag                                                   20


<210>  23629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23629
ugaauugccu uucucagagc                                                   20


<210>  23630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23630
gcuuaauuaa aaguagauau                                                   20


<210>  23631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23631
caggcuguua gagccagaau                                                   20


<210>  23632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23632
cuggcaccuc cuguuuuccc                                                   20


<210>  23633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23633
cuaugugaag uaauuucuga                                                   20


<210>  23634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23634
aauggcaguu auggggcuga                                                   20


<210>  23635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23635
gccccauaac ugccauuaga                                                   20


<210>  23636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23636
cguuuuuaua ccagauccug                                                   20


<210>  23637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23637
cgaacuccug agcucaggca                                                   20


<210>  23638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23638
cagcuauuug ggaggcugag                                                   20


<210>  23639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23639
ccaggcugga gugcaguggc                                                   20


<210>  23640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23640
ugcucuguca ccaggcugga                                                   20


<210>  23641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23641
caaaaaaaaa aaagagaccc                                                   20


<210>  23642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23642
cuuuuuuuuu uuugagacgg                                                   20


<210>  23643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23643
uguucuucca aggacuccau                                                   20


<210>  23644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23644
uuggaagaac aggaccagga                                                   20


<210>  23645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23645
gucuguguag uuauauaugu                                                   20


<210>  23646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23646
guguaguuau auauguguug                                                   20


<210>  23647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23647
ggaguucgag accagccugg                                                   20


<210>  23648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23648
cgaacuccug accucaggcg                                                   20


<210>  23649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23649
ccacuaaaaa uacaaaaauu                                                   20


<210>  23650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23650
ggaugacaga gugagacucu                                                   20


<210>  23651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23651
uccagacuug ggugcagugg                                                   20


<210>  23652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23652
cacucuguca uccagacuug                                                   20


<210>  23653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23653
caaaauaaaa auaaaaauaa                                                   20


<210>  23654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23654
uuauuuucac caguaaccuu                                                   20


<210>  23655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23655
aauggcguga ucuaggcuca                                                   20


<210>  23656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23656
gccucucggg guucaagcaa                                                   20


<210>  23657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23657
ugaacuccug accucaugau                                                   20


<210>  23658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23658
ggaguucaag accagccugg                                                   20


<210>  23659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23659
uaaacugcuu ugacuuuucu                                                   20


<210>  23660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23660
aagcaguuua ugaccuuaaa                                                   20


<210>  23661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23661
gcaggccuua ucuagaaucu                                                   20


<210>  23662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23662
uaaacacucc ucuuuuuaaa                                                   20


<210>  23663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23663
aaccaugcca uagauggccu                                                   20


<210>  23664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23664
auauguucac acacagaauu                                                   20


<210>  23665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23665
cgcucuguca cccaggcugg                                                   20


<210>  23666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23666
cccaggcugg agugcagugg                                                   20


<210>  23667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23667
cuacuaaaaa uacaaacauu                                                   20


<210>  23668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23668
ugaacuccug accucgugau                                                   20


<210>  23669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23669
ggaguucaag accagccugg                                                   20


<210>  23670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23670
ccacgccugg ccaacagggu                                                   20


<210>  23671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23671
ggagaucgag accauccggg                                                   20


<210>  23672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23672
cgaucuccug accucgugau                                                   20


<210>  23673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23673
cagcuacuca ggaggcugag                                                   20


<210>  23674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23674
cgcuguguug cccaggcugg                                                   20


<210>  23675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23675
aaaaaaaaaa aaagucucaa                                                   20


<210>  23676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23676
caaacuagcc cuggguuggg                                                   20


<210>  23677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23677
ucuuuaaccc auuuuuaacc                                                   20


<210>  23678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23678
cucuggguua aaaauggguu                                                   20


<210>  23679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23679
gccaauuugu gcugcagccu                                                   20


<210>  23680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23680
gugcacuguu guucauucag                                                   20


<210>  23681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23681
ucuuuaguaa gauuucacca                                                   20


<210>  23682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23682
uacagaaaug gugaaaucuu                                                   20


<210>  23683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23683
gaaagaaacu gguagaaaau                                                   20


<210>  23684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23684
gauguaagag gccucuaacu                                                   20


<210>  23685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23685
aggaauagau uugauacggu                                                   20


<210>  23686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23686
ccaaagaaaa uggauggguc                                                   20


<210>  23687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23687
ucucuuggau uuuggagauc                                                   20


<210>  23688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23688
auugauuucu cagagcagcu                                                   20


<210>  23689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23689
agcagguacc uuacuuguuc                                                   20


<210>  23690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23690
uuagaagcuu uacuuuggau                                                   20


<210>  23691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23691
gaagugggau ccaaaguaaa                                                   20


<210>  23692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23692
ucagaauccc agcagauuca                                                   20


<210>  23693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23693
cucugaaucu gcugggauuc                                                   20


<210>  23694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23694
gaacaaauuu acagacaaaa                                                   20


<210>  23695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23695
guaaauuugu ucugaccaug                                                   20


<210>  23696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23696
cuucccguuu uuugucugua                                                   20


<210>  23697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23697
uugccaaucc cagcagccau                                                   20


<210>  23698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23698
accuauaagu uagguuguag                                                   20


<210>  23699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23699
uuguggauga acuacaaccu                                                   20


<210>  23700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23700
uucucaggcc auauuuaguu                                                   20


<210>  23701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23701
uauaggugua aaagcaaacu                                                   20


<210>  23702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23702
uacagucacc cccaccaucu                                                   20


<210>  23703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23703
cccccaccau cuaucauuca                                                   20


<210>  23704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23704
ccaugaaaca cuaauuccac                                                   20


<210>  23705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23705
aauucauaaa aacagagggc                                                   20


<210>  23706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23706
caguggaauc agacagcauu                                                   20


<210>  23707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23707
gauuccacug agacaggaga                                                   20


<210>  23708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23708
caaggggcaa augcugucug                                                   20


<210>  23709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23709
cgcucugucg cccaggcugg                                                   20


<210>  23710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23710
cccaggcugg agugcagugg                                                   20


<210>  23711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23711
cagccucccg aguagcuggg                                                   20


<210>  23712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23712
cagcuacucg ggaggcugag                                                   20


<210>  23713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23713
cuacuaaaga uacaaaaaau                                                   20


<210>  23714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23714
ucaucuccug accucgugau                                                   20


<210>  23715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23715
ggagaugaag accauccugg                                                   20


<210>  23716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23716
cagggugggg ugcaguggcu                                                   20


<210>  23717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23717
uuaugcuaag ugaaaaagcc                                                   20


<210>  23718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23718
gaauuucccu ccuauuuaag                                                   20


<210>  23719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23719
caaugcugac cccaagagag                                                   20


<210>  23720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23720
gcauugggac cccuuuccag                                                   20


<210>  23721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23721
gaauucuuuc uugagcaaga                                                   20


<210>  23722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23722
acagaauaaa augaaaguaa                                                   20


<210>  23723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23723
caaaaauaaa uaaauaaaua                                                   20


<210>  23724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23724
cccuuuguug cccaggcugg                                                   20


<210>  23725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23725
cagcuacuca ggaggcugag                                                   20


<210>  23726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23726
cuacuaaaaa uacaaaaaau                                                   20


<210>  23727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23727
caaucuccug accuugugau                                                   20


<210>  23728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23728
ggagauugag accauccugg                                                   20


<210>  23729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23729
ucugcccgcc uuggccuccc                                                   20


<210>  23730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23730
ggaguuugag accagcuuga                                                   20


<210>  23731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23731
caaacuccug accucagguc                                                   20


<210>  23732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23732
agcuggucuc aaacuccuga                                                   20


<210>  23733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23733
caaaagaaaa aaaaaaaaua                                                   20


<210>  23734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23734
uggggcuggu gggagugccu                                                   20


<210>  23735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23735
uugugaccug uaucuugugu                                                   20


<210>  23736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23736
caaagaccuu acugauaaaa                                                   20


<210>  23737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23737
gccuccuacc ucauccugug                                                   20


<210>  23738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23738
caggaugagg uaggaggcug                                                   20


<210>  23739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23739
gccucauuuu accccgcccc                                                   20


<210>  23740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23740
gaggcguugg aaccagaaca                                                   20


<210>  23741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23741
ugcucuguca cccaggcugg                                                   20


<210>  23742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23742
cccaggcugg agugcugugg                                                   20


<210>  23743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23743
cagcuacucg ggaggcugag                                                   20


<210>  23744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23744
uugcagauga aucguaaccu                                                   20


<210>  23745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23745
gccuaccuac uaugcuaggu                                                   20


<210>  23746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23746
cagccaguuc cugcagccag                                                   20


<210>  23747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23747
ggcugcagga acuggcugag                                                   20


<210>  23748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23748
auaaauuugc uuugaccaca                                                   20


<210>  23749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23749
aagcaaauuu auggacagaa                                                   20


<210>  23750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23750
cccugaaucu gcugugauuc                                                   20


<210>  23751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23751
cagaaucaca gcagauucag                                                   20


<210>  23752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23752
uuuuaaaugg cuuuucagua                                                   20


<210>  23753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23753
aaaaauagaa aauugguaga                                                   20


<210>  23754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23754
caaaaaaaga aaaaaaaaau                                                   20


<210>  23755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23755
cgcuccguca cccaggcugg                                                   20


<210>  23756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23756
cccaggcugg agugcagugg                                                   20


<210>  23757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23757
ggcuggucuc aaacuccuga                                                   20


<210>  23758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23758
caaacuccug accucaggug                                                   20


<210>  23759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23759
ggaguuugag accagccuga                                                   20


<210>  23760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23760
accugccuug gccucccaaa                                                   20


<210>  23761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23761
cuguguuuuu uguuuuuuuu                                                   20


<210>  23762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23762
caaaaaaaaa aacaaaaaac                                                   20


<210>  23763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23763
cauucauucu gucacccagg                                                   20


<210>  23764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23764
cccaggcugg aguucagugg                                                   20


<210>  23765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23765
ccuggguucc agugauucuc                                                   20


<210>  23766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23766
gucuccugag uagcuguguu                                                   20


<210>  23767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23767
ccugaguagc uguguuccug                                                   20


<210>  23768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23768
uucgaugguu auuuaauacu                                                   20


<210>  23769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23769
uucaaaagau uuaacugugc                                                   20


<210>  23770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23770
cucuucagaa aagugauagg                                                   20


<210>  23771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23771
uagcaauuuu aagaaguccu                                                   20


<210>  23772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23772
ucauuucuac auuuccuuac                                                   20


<210>  23773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23773
cuucaaucuu uccucacacu                                                   20


<210>  23774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23774
acuacauuua cacauuuuaa                                                   20


<210>  23775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23775
cauuuaauuu agaaaguuua                                                   20


<210>  23776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23776
ucgguaaggu uuucuuuuca                                                   20


<210>  23777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23777
gcagcucgau uuuacaggcu                                                   20


<210>  23778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23778
accaugugca caguaaggag                                                   20


<210>  23779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23779
cccgaguaga gaccaauuug                                                   20


<210>  23780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23780
cuacucgggg gacacuaugu                                                   20


<210>  23781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23781
aaccaaucuu ugggcccugu                                                   20


<210>  23782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23782
aauuuacaca gggcccaaag                                                   20


<210>  23783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23783
auaaaacccu guccauucug                                                   20


<210>  23784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23784
auucugccgc aggcuggaag                                                   20


<210>  23785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23785
uccagccugc ggcagaaugg                                                   20


<210>  23786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23786
ccuauagaga gagaggggug                                                   20


<210>  23787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23787
cugaaguggc auaauaccca                                                   20


<210>  23788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23788
ucaggauuuc cugaggcugu                                                   20


<210>  23789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23789
gggcacagcu ugguuuuaua                                                   20


<210>  23790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23790
cccuaaaaug uauaaaacca                                                   20


<210>  23791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23791
caugucuccc uaaaauguau                                                   20


<210>  23792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23792
auucauauau guaagaagua                                                   20


<210>  23793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23793
agaaaggcgg ggacaacuug                                                   20


<210>  23794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23794
ccgccuuucu ggacggaacc                                                   20


<210>  23795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23795
cagguagaca aaugguugca                                                   20


<210>  23796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23796
accugugacc uagaagcucu                                                   20


<210>  23797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23797
auugacuggg cgcaguggcu                                                   20


<210>  23798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23798
auagacgcau auucugauug                                                   20


<210>  23799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23799
ggaguuugag agcagcccgg                                                   20


<210>  23800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23800
cuacuaaaaa uacaaaaaau                                                   20


<210>  23801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23801
caaagucagg agauugagac                                                   20


<210>  23802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23802
ggagauugag accauccugg                                                   20


<210>  23803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23803
caaucuccug acuuugugac                                                   20


<210>  23804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23804
cagcuacucg gcaggcugag                                                   20


<210>  23805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23805
gggcuggagu gcaguggugu                                                   20


<210>  23806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23806
uccgggcugg agugcagugg                                                   20


<210>  23807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23807
ugcccugucg uccgggcugg                                                   20


<210>  23808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23808
uccuucugcu cacugagaua                                                   20


<210>  23809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23809
cagcuacuug ggaggcugag                                                   20


<210>  23810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23810
cacuaugugu ccaggcuggu                                                   20


<210>  23811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23811
aggcuggucu aaaaccccug                                                   20


<210>  23812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23812
aaaaccccug agcucaaaug                                                   20


<210>  23813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23813
ucccgccuca gccucccgaa                                                   20


<210>  23814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23814
acauuuuuau aaauugcuaa                                                   20


<210>  23815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23815
ggugugagcc cggacuucga                                                   20


<210>  23816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23816
gggcucacac cagaccucca                                                   20


<210>  23817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23817
aacaccuccc cucugcggcc                                                   20


<210>  23818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23818
aggcggugaa gcacaggccg                                                   20


<210>  23819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23819
cccuucggcu cauucucgaa                                                   20


<210>  23820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23820
caaacuucac uucuccugug                                                   20


<210>  23821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23821
aagguccugg ccccuuucuc                                                   20


<210>  23822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23822
uggccccuuu cucuucugcu                                                   20


<210>  23823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23823
agagaaccgc acuuacccuc                                                   20


<210>  23824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23824
guucuaauga uaaagcagag                                                   20


<210>  23825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23825
ugggaaaccg caagagucug                                                   20


<210>  23826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23826
agcagaagca cagcccacau                                                   20


<210>  23827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23827
uuccugagca agaacucuaa                                                   20


<210>  23828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23828
caguccaacc ggaccuuuua                                                   20


<210>  23829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23829
aaccggaccu uuuacuaaag                                                   20


<210>  23830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23830
gguuggacug ggacauaggu                                                   20


<210>  23831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23831
ucccuggggu uggagccuuu                                                   20


<210>  23832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23832
gagacacgac guagccuuca                                                   20


<210>  23833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23833
ccgacccccu acuaaaggcu                                                   20


<210>  23834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23834
ugucuccgac ccccuacuaa                                                   20


<210>  23835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23835
ugaaggcuac gucgugucuc                                                   20


<210>  23836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23836
aguuacacga ucccuguaag                                                   20


<210>  23837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23837
guugaaguaa gugcuacaaa                                                   20


<210>  23838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23838
cgagggaaag aaagucagcg                                                   20


<210>  23839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23839
gcguggcuug ggaguuggga                                                   20


<210>  23840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23840
ugcugcuccc aacucccaag                                                   20


<210>  23841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23841
uaagauaucu ugagccacug                                                   20


<210>  23842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23842
uacaagaacc aggcagcccu                                                   20


<210>  23843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23843
uccuacaaga accaggcagc                                                   20


<210>  23844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23844
gucuaucugu caguggcaga                                                   20


<210>  23845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23845
aucugucagu ggcagagcca                                                   20


<210>  23846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23846
guggcagagc cagccuugga                                                   20


<210>  23847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23847
cugcacuggc caggcaugca                                                   20


<210>  23848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23848
agugcuacug aacagaaugu                                                   20


<210>  23849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23849
caucuagaug gggccuucug                                                   20


<210>  23850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23850
ugccccacca gcucugucuc                                                   20


<210>  23851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23851
uuguccugcc ccaccagcuc                                                   20


<210>  23852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23852
caagaagccc ccucucucca                                                   20


<210>  23853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23853
ccugggaggg augaggccac                                                   20


<210>  23854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23854
cuaauucuuu cuugcagcag                                                   20


<210>  23855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23855
ugaacucuug gccucaagca                                                   20


<210>  23856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23856
auaaucccag cgcuugggga                                                   20


<210>  23857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23857
gcacccaguu ccugccacag                                                   20


<210>  23858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23858
ccucauuaga acaaaagaug                                                   20


<210>  23859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23859
caacugcuca ggaggcugag                                                   20


<210>  23860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23860
cugcuaaaaa uacaaaaauu                                                   20


<210>  23861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23861
uuuggccagg cacgguggcu                                                   20


<210>  23862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23862
aagugcuacc cuucaaaaaa                                                   20


<210>  23863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23863
gauuguuuga gccugguguu                                                   20


<210>  23864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23864
ggaauauuuc aagcccauuc                                                   20


<210>  23865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23865
uuauaagauu uugguaucaa                                                   20


<210>  23866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23866
gguaauacuu uauuaagggu                                                   20


<210>  23867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23867
caucauaaca uagugggguu                                                   20


<210>  23868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23868
aaugccuuua cagcaucuau                                                   20


<210>  23869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23869
auaaaauaaa uuaguuacuc                                                   20


<210>  23870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23870
caaaaaaaaa aaagaagaaa                                                   20


<210>  23871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23871
ugcucuguug ccaggcugga                                                   20


<210>  23872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23872
cagcuacucg ggaggcugag                                                   20


<210>  23873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23873
ggcuggucuu gaacucccaa                                                   20


<210>  23874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23874
ugaacuccca accucacgua                                                   20


<210>  23875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23875
auaagcauca guauuaagga                                                   20


<210>  23876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23876
gagcauagcu aaggcaggcu                                                   20


<210>  23877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23877
gugucugagc auagcuaagg                                                   20


<210>  23878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23878
gccuacaauu ggcaaaauca                                                   20


<210>  23879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23879
acugcagagc aucugcuguu                                                   20


<210>  23880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23880
caagggcaaa cagcagaugc                                                   20


<210>  23881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23881
ugugaagcug ggaagcuccc                                                   20


<210>  23882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23882
aaaaauuuua guugaaccag                                                   20


<210>  23883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23883
caaacuuagg cugguucaac                                                   20


<210>  23884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23884
ucaauguaca uggaaguucc                                                   20


<210>  23885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23885
gucaucaaug uacauggaag                                                   20


<210>  23886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23886
ggauuuauuc auuauguuca                                                   20


<210>  23887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23887
agaucagcaa auacccgcaa                                                   20


<210>  23888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23888
cacucuguug ccaggcugga                                                   20


<210>  23889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23889
cuacuaaaau uacaaaaauc                                                   20


<210>  23890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23890
cgaucucuug acgucaugau                                                   20


<210>  23891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23891
agagaucgag accauccugg                                                   20


<210>  23892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23892
ugaucugucc accucggccu                                                   20


<210>  23893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23893
accucggccu cccaaagugc                                                   20


<210>  23894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23894
cgccuauaau cccagcacuu                                                   20


<210>  23895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23895
gagcuaagcc ucuugagcau                                                   20


<210>  23896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23896
ccuaugcuca agaggcuuag                                                   20


<210>  23897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23897
caggcaauuc cuuuccacuu                                                   20


<210>  23898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23898
acuuuggggu ccaccccacc                                                   20


<210>  23899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23899
accccaccca agaagaagga                                                   20


<210>  23900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23900
uccuucuucu uggguggggu                                                   20


<210>  23901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23901
ucugggacca uaccaauccc                                                   20


<210>  23902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23902
cagaggacca uccauauuuc                                                   20


<210>  23903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23903
uaggccaucu uaauccaagu                                                   20


<210>  23904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23904
caggagccug gcauugcaaa                                                   20


<210>  23905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23905
uuugaagcuu aagguauuau                                                   20


<210>  23906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23906
agcacacaaa cacaaauuac                                                   20


<210>  23907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23907
agauaaugga gauaugaaau                                                   20


<210>  23908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23908
guauuucaua ucuccauuau                                                   20


<210>  23909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23909
cauuuuauag uuucugauuu                                                   20


<210>  23910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23910
guauaaauua cggucccgaa                                                   20


<210>  23911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23911
cgaaaacugc agaauuccag                                                   20


<210>  23912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23912
gaugacacua cccagaauaa                                                   20


<210>  23913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23913
ucugacuuac uuccuaguuc                                                   20


<210>  23914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23914
uugaaacacg gcuucuguuc                                                   20


<210>  23915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23915
ccguccuuga aacacggcuu                                                   20


<210>  23916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23916
agacaaugac aaacaccauc                                                   20


<210>  23917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23917
ggacuugcuu ucacaguaug                                                   20


<210>  23918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23918
uugucuggac uugcuuucac                                                   20


<210>  23919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23919
uguguauugu ugaugguguu                                                   20


<210>  23920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23920
ccauuaaaug caucuuaugc                                                   20


<210>  23921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23921
cuggcccugg gaugaugaga                                                   20


<210>  23922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23922
caccuuaggg aguucacuag                                                   20


<210>  23923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23923
uucuggguau uuguagggaa                                                   20


<210>  23924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23924
uugcugguga aaagaacauc                                                   20


<210>  23925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23925
ggauguucuu uucaccagca                                                   20


<210>  23926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23926
ccuuugguaa ccuagcaaca                                                   20


<210>  23927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23927
gcuuguuggc cagauggccc                                                   20


<210>  23928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23928
cuccuuacac ccccagacgu                                                   20


<210>  23929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23929
ggggguguaa ggagagacaa                                                   20


<210>  23930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23930
uugguuuucu guaguuuugc                                                   20


<210>  23931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23931
auuucauggc ugcugcuuug                                                   20


<210>  23932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23932
caacagcaag aaugaaaagu                                                   20


<210>  23933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23933
uccacuuuuc auucuugcug                                                   20


<210>  23934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23934
ggagaccaag accauccugg                                                   20


<210>  23935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23935
ccugaccucg ugauccaccc                                                   20


<210>  23936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23936
uggucuccug accucgugau                                                   20


<210>  23937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23937
cuacuaaaaa uacaaaaaaa                                                   20


<210>  23938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23938
ggcauggugg ugggugccug                                                   20


<210>  23939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23939
cagcuacucg ggaggcugag                                                   20


<210>  23940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23940
cccaggcugg agugcagugg                                                   20


<210>  23941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23941
ugcucuguca cccaggcugg                                                   20


<210>  23942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23942
caaaaaaaaa aaaaaaaaaa                                                   20


<210>  23943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23943
cccuuuuuuu uuuuuuuuuu                                                   20


<210>  23944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23944
ucuauugcgg aaaucuuucc                                                   20


<210>  23945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23945
aaggaauucu aaaggaugcu                                                   20


<210>  23946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23946
uuuucuucug ccuggaaagc                                                   20


<210>  23947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23947
gcuuuuguuu aaauuggccc                                                   20


<210>  23948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23948
cuaucuuuug uaacauauau                                                   20


<210>  23949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23949
agauggauuc ucacucuguc                                                   20


<210>  23950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23950
cccaggcuac agugaaaugg                                                   20


<210>  23951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23951
cggcucacug caaccucugc                                                   20


<210>  23952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23952
ugaacaccug accucaggug                                                   20


<210>  23953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23953
gguguucaag accagccugg                                                   20


<210>  23954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23954
cccuagaaau uacaacauuc                                                   20


<210>  23955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23955
ccucuuuuca uggucacccu                                                   20


<210>  23956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23956
cacuuuguca cccaggcugg                                                   20


<210>  23957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23957
cccaggcugg aguguugugg                                                   20


<210>  23958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23958
ugaacuccug accucaggcg                                                   20


<210>  23959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23959
ggaguucaag accagccugg                                                   20


<210>  23960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23960
gauuuuauuu uugaaccucu                                                   20


<210>  23961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23961
uucuguauau ccuaccagcu                                                   20


<210>  23962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23962
gucuuucugu auauccuacc                                                   20


<210>  23963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23963
aagaccccac auaagaagcu                                                   20


<210>  23964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23964
uugacaaccc ucguuuuuaa                                                   20


<210>  23965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23965
uguuuccuua gguucuaggu                                                   20


<210>  23966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23966
uccuucaucu guccuguuuc                                                   20


<210>  23967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23967
ugcgccucag ccauccuaug                                                   20


<210>  23968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23968
cauaggaugg cugaggcgca                                                   20


<210>  23969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23969
gcagcugggc ccgugcucuu                                                   20


<210>  23970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23970
agcaacugga gagcagagga                                                   20


<210>  23971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23971
gcgucagggu uuccuucuuu                                                   20


<210>  23972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23972
ggguuuccuu cuuuuccagc                                                   20


<210>  23973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23973
cgggucgggg cugcucccgc                                                   20


<210>  23974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23974
gggcugcucc cgcuuacugc                                                   20


<210>  23975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23975
ugccgagaag agagaagagg                                                   20


<210>  23976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23976
ugcuuagcuc cccgcccagu                                                   20


<210>  23977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23977
cugcuaugac uuggugacua                                                   20


<210>  23978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23978
uagcagugac ucucucuggg                                                   20


<210>  23979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23979
ccaagucaua gcagugacuc                                                   20


<210>  23980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23980
caaaaaaaaa aaaaagagcg                                                   20


<210>  23981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23981
ugcucuguca cccaggcugg                                                   20


<210>  23982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23982
cccaggcugg agugcagugg                                                   20


<210>  23983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23983
ggcggacuug aacuccugac                                                   20


<210>  23984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23984
gccugaccaa caagaugaaa                                                   20


<210>  23985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23985
ggaguucaag uccgccugac                                                   20


<210>  23986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23986
cccauucuaa agaaaaaaca                                                   20


<210>  23987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23987
gcuagcaugu uguaagccuu                                                   20


<210>  23988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23988
caagugcuca ucuggaacag                                                   20


<210>  23989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23989
uuagaauccu guuccagaug                                                   20


<210>  23990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23990
uaaguguugc uauaauaaau                                                   20


<210>  23991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23991
ggcaugugug aucaaugauu                                                   20


<210>  23992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23992
cugaacagca aaaacauuuc                                                   20


<210>  23993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23993
cugaggccua aaaaugggca                                                   20


<210>  23994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23994
ggcauggugu cucugaggcc                                                   20


<210>  23995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23995
ugacagucca uuucuguaag                                                   20


<210>  23996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23996
agacacaggu uuuuaaaguu                                                   20


<210>  23997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23997
auuucuguaa gucuuucaca                                                   20


<210>  23998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23998
uucacauuag auuuccuguc                                                   20


<210>  23999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  23999
ggaugauagu caauucuagg                                                   20


<210>  24000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24000
auucuaggca gaugauguuu                                                   20


<210>  24001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24001
cgaugaucca uugccucccu                                                   20


<210>  24002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24002
uucuguuaua ugcucccaaa                                                   20


<210>  24003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24003
cagcagcuca gacggaagug                                                   20


<210>  24004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24004
gagcugcugu gacuccaggu                                                   20


<210>  24005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24005
uuccagccug gccuggaauu                                                   20


<210>  24006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24006
ucugggcccc cuccuuccag                                                   20


<210>  24007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24007
cagccaacac aucccauucc                                                   20


<210>  24008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24008
uucccuucau uuuaugugau                                                   20


<210>  24009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24009
uuccuucagc uagcuauggc                                                   20


<210>  24010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24010
cuguccuucc uucagcuagc                                                   20


<210>  24011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24011
uacacuagcu aagaggcaaa                                                   20


<210>  24012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24012
cuaaagaagg ucagagcggc                                                   20


<210>  24013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24013
gagcggcugc uagggugcaa                                                   20


<210>  24014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24014
cauaacaaua aguaauagag                                                   20


<210>  24015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24015
cucauucagg uugauguccu                                                   20


<210>  24016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24016
uaagccccag aaccucagaa                                                   20


<210>  24017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24017
ccaaauacaa ucccauucug                                                   20


<210>  24018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24018
gauuauggcc cacccuaaug                                                   20


<210>  24019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24019
uacaagaaga gauuaggaca                                                   20


<210>  24020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24020
uaaucucuuc uuguaagaca                                                   20


<210>  24021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24021
guguccuaau cucuucuugu                                                   20


<210>  24022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24022
cucugagcau guccgugucc                                                   20


<210>  24023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24023
ucacguggcc gucccucuga                                                   20


<210>  24024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24024
gcaagucaag gacagggcuc                                                   20


<210>  24025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24025
aggacagggc ucaggggaaa                                                   20


<210>  24026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24026
uugacuugca gacagcugcc                                                   20


<210>  24027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24027
gagaugaagg uguuggcaag                                                   20


<210>  24028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24028
uagaggcuag aaguccgaga                                                   20


<210>  24029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24029
gugguacuuu guuauggcag                                                   20


<210>  24030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24030
ucugcugcug gaacaaauca                                                   20


<210>  24031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24031
agucauagag uuauauguag                                                   20


<210>  24032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24032
uagaguuaua uguaguuacg                                                   20


<210>  24033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24033
cacguucugu gggucaggaa                                                   20


<210>  24034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24034
ggaauuugga cccagcuuaa                                                   20


<210>  24035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24035
aaauuccuga cccacagaac                                                   20


<210>  24036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24036
aauaccagcu gccucccacc                                                   20


<210>  24037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24037
cuuuccaauc ucacguggug                                                   20


<210>  24038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24038
agcaggccau gaggaacugg                                                   20


<210>  24039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24039
ucgccaugug ggccucucca                                                   20


<210>  24040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24040
gcugccaugu uggagaggcc                                                   20


<210>  24041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24041
cccuggcccu cucuguugcc                                                   20


<210>  24042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24042
uacccuuuug cgaccuaguc                                                   20


<210>  24043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24043
caaaagggua ugacuucagu                                                   20


<210>  24044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24044
uggggugaca uuccaucacc                                                   20


<210>  24045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24045
ccccaugacu aggucgcaaa                                                   20


<210>  24046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24046
uacaagggug ucaauaccag                                                   20


<210>  24047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24047
auaccaggag gugaggggug                                                   20


<210>  24048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24048
gcccacugag guaacuaaca                                                   20


<210>  24049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24049
ggccucaagg uuguuaguua                                                   20


<210>  24050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24050
acugugucag gccucaaggu                                                   20


<210>  24051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24051
caaaaauaaa uaaauaaaua                                                   20


<210>  24052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24052
cacucuuguc acccaggcug                                                   20


<210>  24053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24053
cccaggcugg agugcaaugg                                                   20


<210>  24054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24054
cagcuauucc ggaggcugag                                                   20


<210>  24055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24055
cuacuaaaaa uacaaaaauu                                                   20


<210>  24056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24056
cgaacuccug accucuggug                                                   20


<210>  24057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24057
ggaguucgag accagccugg                                                   20


<210>  24058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24058
cuaaaaaaau uaaguuccag                                                   20


<210>  24059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24059
cucuaucacc caagcuggag                                                   20


<210>  24060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24060
uucucaagaa aagggaggcu                                                   20


<210>  24061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24061
ccaguggggu agcaguagcc                                                   20


<210>  24062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24062
uaaagggaaa cccagcauug                                                   20


<210>  24063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24063
cagagccugu ccuaaaggga                                                   20


<210>  24064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24064
ccugcucugu ggccacaaac                                                   20


<210>  24065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24065
cugaggccaa ccuuacuccc                                                   20


<210>  24066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24066
agccugccca gcagggagua                                                   20


<210>  24067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24067
ccagagccuc cugccuuuug                                                   20


<210>  24068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24068
uggucuccag agccuccugc                                                   20


<210>  24069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24069
caggcgugag ggggugcccc                                                   20


<210>  24070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24070
guggggcacc cccucacgcc                                                   20


<210>  24071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24071
uucagcagca gcucagcaga                                                   20


<210>  24072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24072
ugccggaagg ucagagcagg                                                   20


<210>  24073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24073
gagcaggggu gcacucccau                                                   20


<210>  24074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24074
ggacucauuc cugugggcgg                                                   20


<210>  24075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24075
cgaccugggg gcguuucuuu                                                   20


<210>  24076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24076
gcgccugcug cccacagagg                                                   20


<210>  24077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24077
ggggcaggcc ugggugguca                                                   20


<210>  24078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24078
cagcgcagcg ccccggaagg                                                   20


<210>  24079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24079
acaggccugg cgccccccau                                                   20


<210>  24080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24080
cacuuggggu ccucaggucg                                                   20


<210>  24081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24081
ucaggucgug ccgaccacgc                                                   20


<210>  24082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24082
ugccgaccac gcgcauucuc                                                   20


<210>  24083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24083
gcacgaccug aggaccccaa                                                   20


<210>  24084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24084
gggugaguau ggcucuggcc                                                   20


<210>  24085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24085
acggccggcu gucgccccgc                                                   20


<210>  24086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24086
ccccgcucca ggcgucggcg                                                   20


<210>  24087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24087
gcgggggauc cuuuccgcau                                                   20


<210>  24088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24088
auggccccgu ccuucauggg                                                   20


<210>  24089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24089
uucaugggcg agccccucca                                                   20


<210>  24090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24090
ccuccccuau cccgcuccgc                                                   20


<210>  24091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24091
ccguccccag caucgccccg                                                   20


<210>  24092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24092
ccagcaucgc cccgccccgc                                                   20


<210>  24093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24093
cgccccgccc cucaggcggc                                                   20


<210>  24094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24094
cgccccgucc cuuccucguc                                                   20


<210>  24095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24095
cuuccucguc ccgccucgcc                                                   20


<210>  24096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24096
cgccucgccg cgacacuuca                                                   20


<210>  24097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24097
cggcgaggcg ggacgaggaa                                                   20


<210>  24098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24098
caccacgccc cguccccucu                                                   20


<210>  24099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24099
ccucuccguu gagccccgcg                                                   20


<210>  24100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24100
gcggccuugc ugugugaggc                                                   20


<210>  24101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24101
gcaggcuagg gcugucaauc                                                   20


<210>  24102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24102
aucaugcugg ccggcguggc                                                   20


<210>  24103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24103
gggacgcaag gcgccguggg                                                   20


<210>  24104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24104
cagacgcugc gccggcggag                                                   20


<210>  24105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24105
cggcagcccc cacggcgccu                                                   20


<210>  24106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24106
aagauggacg gccgcucagg                                                   20


<210>  24107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24107
aucuuggacc cgucccggca                                                   20


<210>  24108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24108
gcccgaggcc uccggggacu                                                   20


<210>  24109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24109
ccggaggccu cgggccgacu                                                   20


<210>  24110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24110
cccgcccggc acggcagucc                                                   20


<210>  24111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24111
ccauggcggu cucccgcccg                                                   20


<210>  24112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24112
cucaaguccu uccagcagca                                                   20


<210>  24113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24113
uuccagcagc agcagcagca                                                   20


<210>  24114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24114
gugcagcggc uccucagcca                                                   20


<210>  24115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24115
cggcgggucc caggcuacgg                                                   20


<210>  24116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24116
caggcuacgg cggggauggc                                                   20


<210>  24117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24117
ccggcccgca ggcugcaggg                                                   20


<210>  24118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24118
cugcggggcc ggggguucgu                                                   20


<210>  24119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24119
cucugucucu gcggggccgg                                                   20


<210>  24120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24120
cucaugggcu cuggguugcu                                                   20


<210>  24121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24121
ucccuugucc ucucgcgagg                                                   20


<210>  24122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24122
ucucgcgagg ggaggcagag                                                   20


<210>  24123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24123
ugaauucacc gaggggaguc                                                   20


<210>  24124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24124
cggccucagc ccucucgccc                                                   20


<210>  24125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24125
gagagggaag agggcugggg                                                   20


<210>  24126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24126
cgcgccccca gcccucuucc                                                   20


<210>  24127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24127
uccacugccc ccacaucucu                                                   20


<210>  24128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24128
uaaaagcauu augucaucca                                                   20


<210>  24129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24129
aaugggagau uucuuuuccu                                                   20


<210>  24130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24130
ggacauuuca uuuaguucau                                                   20


<210>  24131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24131
ugacaaugua ggaagagccu                                                   20


<210>  24132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24132
gcaggcguuu gaaugaguug                                                   20


<210>  24133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24133
ggcuugccag aauacggggg                                                   20


<210>  24134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24134
gcagacuccg ugggcaucuc                                                   20


<210>  24135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24135
gcggaccccc cguauucugg                                                   20


<210>  24136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24136
gcaaugaagc aaacagaaac                                                   20


<210>  24137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24137
cucuuuuccu guuucaaaaa                                                   20


<210>  24138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24138
ugggguuccg cuagauguuu                                                   20


<210>  24139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24139
gugugucgag uguacaguag                                                   20


<210>  24140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24140
aguguacagu aggaguuagg                                                   20


<210>  24141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24141
cagauggcau uugguaagaa                                                   20


<210>  24142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24142
uaacagagau auucuuacca                                                   20


<210>  24143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24143
cgucuucaaa guuuaauuag                                                   20


<210>  24144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24144
ucaaaguuua auuagaaaau                                                   20


<210>  24145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24145
uaaaaguuca cacauugcau                                                   20


<210>  24146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24146
uccuucccau caggagcccu                                                   20


<210>  24147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24147
gaagcagccc agcagaaagg                                                   20


<210>  24148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24148
aaucagcaua agaaagagaa                                                   20


<210>  24149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24149
aggcagcaaa ggaaauuucu                                                   20


<210>  24150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24150
ugauuaaauu uuuuaaauaa                                                   20


<210>  24151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24151
accuaggccu cccaaagugc                                                   20


<210>  24152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24152
ggaguuugag accagccugg                                                   20


<210>  24153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24153
caaacuccug accucaggug                                                   20


<210>  24154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24154
cuacuaaaaa uacaaaaauu                                                   20


<210>  24155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24155
ugguggcacg ugccuguaau                                                   20


<210>  24156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24156
gcagugaguu gagaucacgc                                                   20


<210>  24157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24157
cccaggcugg agugcagugg                                                   20


<210>  24158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24158
cgcucuguca cccaggcugg                                                   20


<210>  24159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24159
auguauuacu uaugcaaaaa                                                   20


<210>  24160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24160
ccaagaacaa gcacuauuuc                                                   20


<210>  24161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24161
cacauuguca cccaggcugg                                                   20


<210>  24162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24162
cccaggcugg agugcaguga                                                   20


<210>  24163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24163
cugccuccca gguucaaaug                                                   20


<210>  24164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24164
agcuaauuuu uguauuuuua                                                   20


<210>  24165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24165
ugaacuccug accuugugau                                                   20


<210>  24166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24166
ggaguucaag accagccugg                                                   20


<210>  24167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24167
accucggccu cccaaagugc                                                   20


<210>  24168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24168
uauuucucug uauuuugcug                                                   20


<210>  24169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24169
cgccaugcau gggccucagu                                                   20


<210>  24170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24170
ucacaguaau uaggaggcaa                                                   20


<210>  24171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24171
gggaaacacc agauaggaau                                                   20


<210>  24172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24172
gcucacugcu gagcccugca                                                   20


<210>  24173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24173
uucauuagaa ugaaagcuuc                                                   20


<210>  24174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24174
auguccuuca uuagaaugaa                                                   20


<210>  24175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24175
ggguuaaucg aguguuaacu                                                   20


<210>  24176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24176
agcaggcuuu cuggguuuug                                                   20


<210>  24177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24177
acacuuagug cuacagcucu                                                   20


<210>  24178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24178
caaaaaaaac aaaacaaaac                                                   20


<210>  24179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24179
auaaucccag cuaaacagga                                                   20


<210>  24180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24180
cgggggaaaa aaaaaaaauu                                                   20


<210>  24181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24181
ugcucugucg cccaggcugg                                                   20


<210>  24182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24182
cccaggcugg agugcagugg                                                   20


<210>  24183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24183
cccaaguagc ugggacuaca                                                   20


<210>  24184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24184
cagcuacuug ggagacugag                                                   20


<210>  24185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24185
agcuaauuuu uuuguauuuu                                                   20


<210>  24186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24186
cuauuaaaaa uacaaaaaaa                                                   20


<210>  24187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24187
ggagaucaag aucauccugg                                                   20


<210>  24188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24188
uccgccgacc uugugauccg                                                   20


<210>  24189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24189
gcggaugacg aggucaggag                                                   20


<210>  24190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24190
cgaacucccg gccucaugug                                                   20


<210>  24191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24191
acugagaaga cagcuuuuuu                                                   20


<210>  24192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24192
ucucagugga ccuucccuga                                                   20


<210>  24193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24193
ugcucuuuaa cccaggcugg                                                   20


<210>  24194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24194
caacacauug ugagguugag                                                   20


<210>  24195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24195
uuacucaaaa gccaucaucu                                                   20


<210>  24196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24196
aguguaaggg uguaugaagu                                                   20


<210>  24197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24197
aaaaucuucc uguuucagga                                                   20


<210>  24198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24198
uuuuaguugg gugaauugag                                                   20


<210>  24199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24199
cccucacuca auucacccaa                                                   20


<210>  24200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24200
aagaggucaa gggagugcca                                                   20


<210>  24201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24201
agggagugcc auaucagacc                                                   20


<210>  24202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24202
gauauggcac ucccuugacc                                                   20


<210>  24203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24203
cuggaggauu agagcagagg                                                   20


<210>  24204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24204
gccagaguuc acuuaagauu                                                   20


<210>  24205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24205
ggguaccggc ugucggcugu                                                   20


<210>  24206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24206
gcugugggca gugugaggaa                                                   20


<210>  24207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24207
uuccucacac ugcccacagc                                                   20


<210>  24208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24208
gucauuccuc acacugccca                                                   20


<210>  24209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24209
ucugauaagc ucuugcuugu                                                   20


<210>  24210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24210
ggggaaauuc aacaauaagu                                                   20


<210>  24211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24211
cccgggcugg agugcaauga                                                   20


<210>  24212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24212
cgaacuucug accucaggug                                                   20


<210>  24213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24213
gaaguucgag accagccugg                                                   20


<210>  24214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24214
gaacccaggc ucuuucuuau                                                   20


<210>  24215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24215
uuuuacuuuc uugauagugu                                                   20


<210>  24216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24216
uuugaagugu aaaaguuuuu                                                   20


<210>  24217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24217
aguuuaucua uuuugucuuu                                                   20


<210>  24218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24218
uugguugcug ugcuucaagu                                                   20


<210>  24219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24219
uaucuaagaa aucauugucu                                                   20


<210>  24220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24220
aauccaaagu caaaaagguu                                                   20


<210>  24221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24221
aaaagguuua cuccuauguu                                                   20


<210>  24222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24222
gauccauuuu gaguuaauuu                                                   20


<210>  24223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24223
aacuuuauuc uuuuccaugu                                                   20


<210>  24224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24224
cagcacuguu uguugaagag                                                   20


<210>  24225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24225
cuucaacaaa cagugcuggg                                                   20


<210>  24226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24226
uuaauuguau aaauuuauuu                                                   20


<210>  24227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24227
agaaauaaau uuauacaauu                                                   20


<210>  24228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24228
guucuaccug uuggucuuua                                                   20


<210>  24229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24229
uuaugucgau ccugugccag                                                   20


<210>  24230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24230
auccugugcc aguaccauac                                                   20


<210>  24231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24231
ugauuacuga aguuuguguc                                                   20


<210>  24232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24232
caguuuaaau ucaugaaaug                                                   20


<210>  24233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24233
cuugcauuuc cguacgaauu                                                   20


<210>  24234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24234
guuucaacaa agaagccaag                                                   20


<210>  24235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24235
uccaccuaug aacaugggca                                                   20


<210>  24236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24236
gauuguaagu auuucgggcu                                                   20


<210>  24237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24237
cugucacagc uacgcggcuc                                                   20


<210>  24238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24238
cagcuacgcg gcucugccau                                                   20


<210>  24239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24239
guguuccaau agaauuuuau                                                   20


<210>  24240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24240
uuaauaaaau ucuauuggaa                                                   20


<210>  24241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24241
ugagauagua uuugauuauu                                                   20


<210>  24242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24242
accauuuaaa aauguaaaaa                                                   20


<210>  24243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24243
uaucauauuu uaaccuagga                                                   20


<210>  24244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24244
caaaaaaaaa aaaaaaaaaa                                                   20


<210>  24245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24245
ugaaccuggg aggcagaggu                                                   20


<210>  24246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24246
cuacuaaaaa uacaaaauua                                                   20


<210>  24247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24247
ggcuggucuu gaacuccuga                                                   20


<210>  24248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24248
ugaacuccug accucaggug                                                   20


<210>  24249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24249
ggaguucaag accagccuga                                                   20


<210>  24250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24250
gucaucuuug ucuaacuucc                                                   20


<210>  24251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24251
ucuuugucua acuuccuaag                                                   20


<210>  24252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24252
aacuuccuaa gaacaaaagu                                                   20


<210>  24253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24253
ucuucccaga uuuuaauaug                                                   20


<210>  24254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24254
uuuuuuguuu gcuugacuga                                                   20


<210>  24255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24255
agcaaacaaa aaaugacaca                                                   20


<210>  24256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24256
uagauauugu uccauagcag                                                   20


<210>  24257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24257
ucuuuuaaaa agaaauucua                                                   20


<210>  24258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24258
cacauuuuug uggcuguaga                                                   20


<210>  24259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24259
ccagcacauu cuacagccac                                                   20


<210>  24260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24260
ccauccccau caccuccauu                                                   20


<210>  24261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24261
accacuugau aaacuaccuu                                                   20


<210>  24262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24262
uauucagaca acaaggagga                                                   20


<210>  24263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24263
gaauaagacu aaauguuuug                                                   20


<210>  24264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24264
cuaacauaca uucuagcccc                                                   20


<210>  24265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24265
auagguccuu gcuaucacag                                                   20


<210>  24266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24266
uugcuaucac agugaggucu                                                   20


<210>  24267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24267
cagggacagu cguuugguau                                                   20


<210>  24268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24268
cugagaccuc acugugauag                                                   20


<210>  24269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24269
uuugguauca uuugggaucu                                                   20


<210>  24270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24270
gcuuaugaga ucccaaauga                                                   20


<210>  24271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24271
agcagagaga gucugcuuau                                                   20


<210>  24272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24272
ggucaagcag agagagucug                                                   20


<210>  24273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24273
guguuuuaac agguucagug                                                   20


<210>  24274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24274
cucacugaac cuguuaaaac                                                   20


<210>  24275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24275
aagcaccuac aguggagcuu                                                   20


<210>  24276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24276
uccucccaaa ugcuugcauu                                                   20


<210>  24277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24277
agguguagcu gagguggccu                                                   20


<210>  24278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24278
cacuaccaau ggcugggagc                                                   20


<210>  24279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24279
uuccaguuca ucuaagcgag                                                   20


<210>  24280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24280
cuccccucau ucgguuguuu                                                   20


<210>  24281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24281
ccuucuaacc acagcucucc                                                   20


<210>  24282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24282
aggcagaguu aacagaaggc                                                   20


<210>  24283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24283
cuaaccucuc aucucucgca                                                   20


<210>  24284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24284
ugugcaccaa gauaagcuug                                                   20


<210>  24285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24285
aaacaaguag uuuaauuuau                                                   20


<210>  24286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24286
caaacuacug guauuacagg                                                   20


<210>  24287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24287
ggccucaggc aauccuccca                                                   20


<210>  24288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24288
ucuggccuca ggcaauccuc                                                   20


<210>  24289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24289
cuacaaaaaa cuuuaaaaaa                                                   20


<210>  24290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24290
cagcuacuca ggaggcugag                                                   20


<210>  24291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24291
aggaguuuga ggcugcagug                                                   20


<210>  24292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24292
cacucucuug cccagguugu                                                   20


<210>  24293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24293
cuaaauauac acacacacac                                                   20


<210>  24294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24294
aagugaucuu uucaucuaaa                                                   20


<210>  24295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24295
cuuauugcug gugggaauau                                                   20


<210>  24296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24296
uaaaacugaa cauaccguua                                                   20


<210>  24297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24297
uucaacaggu gaaugguuaa                                                   20


<210>  24298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24298
uuuuauaacc acauucaccu                                                   20


<210>  24299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24299
uuuuuuuuuu uuuuuuuuuu                                                   20


<210>  24300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24300
ccaaaaaaaa aaaaaaaaaa                                                   20


<210>  24301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24301
ugcucuguug cccaggcugg                                                   20


<210>  24302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24302
cagucuccca uguucagagu                                                   20


<210>  24303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24303
cccauguuca gagugaaaca                                                   20


<210>  24304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24304
uguguguugg auuauuugga                                                   20


<210>  24305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24305
gacguggugg cucaugccug                                                   20


<210>  24306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24306
gaccugaucu ugauguuuua                                                   20


<210>  24307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24307
ggaguucgag accagccggg                                                   20


<210>  24308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24308
cgaacuccug accucaagug                                                   20


<210>  24309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24309
agaugggguu ucaucauguu                                                   20


<210>  24310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24310
cagcuacuug ggaggcugag                                                   20


<210>  24311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24311
cacaggcuga agugcaaugg                                                   20


<210>  24312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24312
uacucuguca cacaggcuga                                                   20


<210>  24313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24313
ggagauccag accaucccgg                                                   20


<210>  24314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24314
ggaucuccug accucgugau                                                   20


<210>  24315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24315
cuacuaaaaa auacaaaaaa                                                   20


<210>  24316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24316
cagcuacuug ggaggcugaa                                                   20


<210>  24317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24317
cccaggcugg agugcagugg                                                   20


<210>  24318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24318
ugcucugucg cccaggcugg                                                   20


<210>  24319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24319
cgggggaaaa aaaaaaauaa                                                   20


<210>  24320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24320
uugaguuuac augccccucc                                                   20


<210>  24321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24321
caaaaaaaaa aaaauuaaaa                                                   20


<210>  24322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24322
ggcucuguuc cccaggcuag                                                   20


<210>  24323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24323
cgaacuccug accucagaug                                                   20


<210>  24324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24324
ggaguucgag accagccugg                                                   20


<210>  24325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24325
cuuucacuuc accuucaaaa                                                   20


<210>  24326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24326
uggcuuuuca aucacuuuug                                                   20


<210>  24327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24327
guuugaguua ucaguucauc                                                   20


<210>  24328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24328
aauaagcaaa ccuggaaguu                                                   20


<210>  24329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24329
uuuaguuuag uuguuuuuag                                                   20


<210>  24330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24330
uauguuuugg aucaccccuc                                                   20


<210>  24331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24331
ucacaguugg cacuaucaaa                                                   20


<210>  24332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24332
uaauaggagg cuuauuccca                                                   20


<210>  24333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24333
ccaaauagcu gggaauaagc                                                   20


<210>  24334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24334
gugugguaug uugauuguag                                                   20


<210>  24335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24335
guuaacgauu uugagaacug                                                   20


<210>  24336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24336
aauaccuacu cuauauauac                                                   20


<210>  24337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24337
ucuggcuuua aaucuccucu                                                   20


<210>  24338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24338
uacagccagc auuuaaaccc                                                   20


<210>  24339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24339
ugguuggcac uucaauuucu                                                   20


<210>  24340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24340
ugguggcuca uaccuauaau                                                   20


<210>  24341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24341
cuacaaaaua uuuugaaaaa                                                   20


<210>  24342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24342
gcgccacuca ggaggcugag                                                   20


<210>  24343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24343
cagccuccug aguggcgcgg                                                   20


<210>  24344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24344
ggaucuugcu cugcugccca                                                   20


<210>  24345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24345
agcuacgcug cucacagaaa                                                   20


<210>  24346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24346
agauccccau ucugcccgca                                                   20


<210>  24347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24347
agaaacacuc acugaaugaa                                                   20


<210>  24348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24348
uucuugguag cugaaaguuc                                                   20


<210>  24349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24349
gacaauaugu gaaaacauag                                                   20


<210>  24350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24350
gacaaugauu cacacggucu                                                   20


<210>  24351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24351
gucagguaau ugcacuuuga                                                   20


<210>  24352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24352
gguaauugca cuuugaacug                                                   20


<210>  24353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24353
agagaaaaua agaacuuugu                                                   20


<210>  24354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24354
uaaugggcua gaauauucuu                                                   20


<210>  24355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24355
cagcuauuuu aaauggauuc                                                   20


<210>  24356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24356
uucuucaucu uaaauggauu                                                   20


<210>  24357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24357
ggauauccuu guauauagcc                                                   20


<210>  24358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24358
ugugcuguuc cuacuauugc                                                   20


<210>  24359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24359
cucuuauuug cuuuuucuug                                                   20


<210>  24360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24360
uauuguaccu cugcuccuag                                                   20


<210>  24361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24361
augccccacg auccccacua                                                   20


<210>  24362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24362
gcuuuccuug cuugaucuuu                                                   20


<210>  24363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24363
aaagcaaagc agcuacaaaa                                                   20


<210>  24364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24364
gaaagauagu caaaagcaaa                                                   20


<210>  24365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24365
ccuacugagc cauuggaaac                                                   20


<210>  24366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24366
gucagaaaaa aauuuuuaga                                                   20


<210>  24367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24367
gaaaaaaauu uuuagacaaa                                                   20


<210>  24368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24368
aaaaauuuuu uucugacuga                                                   20


<210>  24369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24369
guacuaaaau caagauuauu                                                   20


<210>  24370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24370
caaaaaaaaa uuaaaaaaag                                                   20


<210>  24371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24371
ggcugaucuc gaacucccaa                                                   20


<210>  24372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24372
caaaaaaaaa aaaaaaacaa                                                   20


<210>  24373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24373
cgaucuguca cccaggcugg                                                   20


<210>  24374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24374
cccaggcugg agugcagugg                                                   20


<210>  24375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24375
cagcuacucg ccaggcugaa                                                   20


<210>  24376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24376
ugaucuccug accucaugac                                                   20


<210>  24377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24377
ggagaucaag accacgguga                                                   20


<210>  24378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24378
ugaggucagg agaucaagac                                                   20


<210>  24379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24379
uuuuauugug guaaaaugca                                                   20


<210>  24380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24380
auuuuaugug cauuuuacca                                                   20


<210>  24381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24381
uaaccauuuu uagggguaca                                                   20


<210>  24382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24382
aaacugaaca ucugucuuca                                                   20


<210>  24383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24383
ucauuaaacu cccuaucauc                                                   20


<210>  24384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24384
cuuucuacuu ucugucugua                                                   20


<210>  24385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24385
guaugagugu aacugcucug                                                   20


<210>  24386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24386
ccagagcagu uacacucaua                                                   20


<210>  24387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24387
aauuugugga aauguugugg                                                   20


<210>  24388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24388
ugaaaauaaa aauauaaaaa                                                   20


<210>  24389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24389
cccagcuuac acagguagca                                                   20


<210>  24390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24390
caaaaaaaaa aaaguaaaga                                                   20


<210>  24391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24391
ugcucuguug cccaggcuag                                                   20


<210>  24392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24392
cagcuacuug ggaggcuggg                                                   20


<210>  24393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24393
ugaucuccug accucgugau                                                   20


<210>  24394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24394
ggagaucaag accauccugg                                                   20


<210>  24395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24395
uuucacaaaa aaaguaaaga                                                   20


<210>  24396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24396
uuguucaucu gaucuccacc                                                   20


<210>  24397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24397
cagagaacau aauuucucuc                                                   20


<210>  24398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24398
auaagcuuuc agagagaaau                                                   20


<210>  24399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24399
ggcuuuauuc uugucauuuu                                                   20


<210>  24400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24400
uuuugucuuu ugauaauuuu                                                   20


<210>  24401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24401
uuugauaauu uucaaaugga                                                   20


<210>  24402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24402
caacauacuu uacuaauaua                                                   20


<210>  24403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24403
gucucuuguu uuuauggagu                                                   20


<210>  24404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24404
cuuguuuuua uggaguaaug                                                   20


<210>  24405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24405
gagagguuau ucuugguuuc                                                   20


<210>  24406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24406
agcacaaaag cuauaaaaaa                                                   20


<210>  24407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24407
cuaaugaggu uauauaaaug                                                   20


<210>  24408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24408
gaagcugcca uuuauauaac                                                   20


<210>  24409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24409
uuuaaaacuu cauguauauu                                                   20


<210>  24410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24410
gcuuuaagcu cucuaaagug                                                   20


<210>  24411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24411
aaguuacugg uuccuaagua                                                   20


<210>  24412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24412
uuuuucccaa acauacuucu                                                   20


<210>  24413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24413
cuaccuacuc aaacagaaug                                                   20


<210>  24414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24414
ccuauaucuu ucagaaacau                                                   20


<210>  24415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24415
agaguuugag accagcugga                                                   20


<210>  24416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24416
caaacucuug accucaggug                                                   20


<210>  24417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24417
agcuggucuc aaacucuuga                                                   20


<210>  24418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24418
cagcuacuug ggaggcugag                                                   20


<210>  24419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24419
cccaggcugg aaugcagugg                                                   20


<210>  24420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24420
caagaaaaaa gagaaaaaag                                                   20


<210>  24421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24421
caccauauua guguugauuu                                                   20


<210>  24422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24422
cauacauuaa gucucaccau                                                   20


<210>  24423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24423
gagaaaugua ucauuucccu                                                   20


<210>  24424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24424
aaauccaccu ucaacaaaau                                                   20


<210>  24425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24425
auacuuuccc caaguucaau                                                   20


<210>  24426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24426
accugucggc accuuguucu                                                   20


<210>  24427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24427
acaguguuuu ucuuaacgau                                                   20


<210>  24428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24428
gcaccuuguu cuccgacucc                                                   20


<210>  24429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24429
gagaacaagg ugccgacagg                                                   20


<210>  24430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24430
caguucugga ggcugggagu                                                   20


<210>  24431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24431
guauguggua uuuuguuaua                                                   20


<210>  24432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24432
uaaucagcuu gaguuucuau                                                   20


<210>  24433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24433
acugauuacu aguguccuaa                                                   20


<210>  24434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24434
aauuggcaaa cauuaagaau                                                   20


<210>  24435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24435
gaggugauac aaccuucuaa                                                   20


<210>  24436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24436
gaccuagcag uuuuaccucu                                                   20


<210>  24437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24437
gacauauaau aaucuaaagc                                                   20


<210>  24438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24438
ugcacugucc gccugggcca                                                   20


<210>  24439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24439
gccugggcca gagugcaaug                                                   20


<210>  24440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24440
ggccaacaca gugaaacccc                                                   20


<210>  24441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24441
cgaacuccug accucaugau                                                   20


<210>  24442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24442
ggaguucgag accagucugg                                                   20


<210>  24443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24443
cuaaaaaaaa uuuuuuuaau                                                   20


<210>  24444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24444
cccaggcagg augcaguugc                                                   20


<210>  24445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24445
cccagguacu caaaaggcug                                                   20


<210>  24446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24446
agaauuccug ggcccaagug                                                   20


<210>  24447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24447
gaaguggugg cucaugccug                                                   20


<210>  24448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24448
caaauauaaa uaucuauugg                                                   20


<210>  24449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24449
uuguuauucu aucuuagcca                                                   20


<210>  24450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24450
uggcaagagg aaaaacugag                                                   20


<210>  24451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24451
ccucucaguu uuuccucuug                                                   20


<210>  24452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24452
ccggagcucc cucugcagcu                                                   20


<210>  24453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24453
uguguguagc ugaguacuga                                                   20


<210>  24454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24454
guacucagcu acacacauga                                                   20


<210>  24455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24455
uuuccgcaca agcaagugcu                                                   20


<210>  24456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24456
cacagggcca ggaagaauuu                                                   20


<210>  24457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24457
ggggcuaggu gggcaaaccc                                                   20


<210>  24458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24458
gaguaacgaa acuuagucug                                                   20


<210>  24459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24459
uacaauucac uucuacgugu                                                   20


<210>  24460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24460
auuucugcuc uuccagccuu                                                   20


<210>  24461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24461
uaaucccugg agccuguaaa                                                   20


<210>  24462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24462
uaggacaaua guggagggaa                                                   20


<210>  24463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24463
uaugacccug ccaaaucccc                                                   20


<210>  24464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24464
gcagauaaac auguaaacaa                                                   20


<210>  24465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24465
cugguuuucc uaggcagagg                                                   20


<210>  24466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24466
cuggguacuu gagauuaggg                                                   20


<210>  24467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24467
ucaccacucc cuaaucucaa                                                   20


<210>  24468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24468
acuaaggguu aaauggauua                                                   20


<210>  24469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24469
uaugucuacu ucuuucuacg                                                   20


<210>  24470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24470
acuucuuucu acgcagacac                                                   20


<210>  24471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24471
gcguagaaag aaguagacau                                                   20


<210>  24472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24472
aauagaaaag gaggaaaugu                                                   20


<210>  24473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24473
ucauggacug uucucaauga                                                   20


<210>  24474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24474
augaugacgg uggcaguuuu                                                   20


<210>  24475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24475
gggagguugg ggggcgccuc                                                   20


<210>  24476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24476
gggagguggg gggcagcccc                                                   20


<210>  24477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24477
gggagguggu gggcagcccc                                                   20


<210>  24478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24478
gggagguggg gggcagcccc                                                   20


<210>  24479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24479
gggagguggg gggcagcccc                                                   20


<210>  24480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24480
gggagguggg gggcagcccc                                                   20


<210>  24481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24481
gggaagugag gagccccucc                                                   20


<210>  24482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24482
gagaagugag gagccccucc                                                   20


<210>  24483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24483
gagacgcucc ucaccuccca                                                   20


<210>  24484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24484
cugaccagcc gccccgucug                                                   20


<210>  24485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24485
gggaggugag gagcgucucu                                                   20


<210>  24486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24486
cugccccacu gccaccccgu                                                   20


<210>  24487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24487
gggaacuuaa gaaugucucu                                                   20


<210>  24488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24488
cggccgggca gaggugcucu                                                   20


<210>  24489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24489
gagaugugaa gagcaccucu                                                   20


<210>  24490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24490
gggaaguggg gagcaccucu                                                   20


<210>  24491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24491
ucccaucuag gaagugagga                                                   20


<210>  24492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24492
gggaagugag gagcgccucu                                                   20


<210>  24493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24493
gggaugugag gagccccucu                                                   20


<210>  24494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24494
aggaagugag gagcguuucu                                                   20


<210>  24495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24495
cuacaaccuu caccucccag                                                   20


<210>  24496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24496
cgcucacuca gugcucagug                                                   20


<210>  24497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24497
gcaaucccgg caccucggga                                                   20


<210>  24498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24498
ggagcuggag accagcccgg                                                   20


<210>  24499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24499
ccagcuccug acugcaagug                                                   20


<210>  24500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24500
ccaccaaaaa acacgaaaac                                                   20


<210>  24501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24501
gacauggcgg ugcgugccug                                                   20


<210>  24502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24502
gacugguuuu cguguuuuuu                                                   20


<210>  24503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24503
agccuuggcu cggcaucaga                                                   20


<210>  24504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24504
cccucugaug ccgagccaag                                                   20


<210>  24505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24505
aaaauuagua ucacuaaacu                                                   20


<210>  24506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24506
aaaaggacau uacauguaaa                                                   20


<210>  24507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24507
uuuuugacau aguuagguug                                                   20


<210>  24508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24508
uacuuuucca uucaaucuga                                                   20


<210>  24509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24509
agcuugcauc uaauucuugu                                                   20


<210>  24510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24510
gauauuaaca gaaccagucu                                                   20


<210>  24511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24511
uuucauaaug augaagggga                                                   20


<210>  24512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24512
ggugcauaaa cauuucagcu                                                   20


<210>  24513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24513
ggcuuugcuu cauguauuuu                                                   20


<210>  24514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24514
guuucuacuu guaguucugu                                                   20


<210>  24515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24515
aguguucuag auccagauau                                                   20


<210>  24516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24516
ccugugcaac cucauuggca                                                   20


<210>  24517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24517
uguaaaugcc aaugagguug                                                   20


<210>  24518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24518
cuucugcugg ugcugggugg                                                   20


<210>  24519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24519
cuaaauuaaa agcauucaaa                                                   20


<210>  24520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24520
gaaaacauac ucugaauaau                                                   20


<210>  24521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24521
gaagugaagu caaaagggaa                                                   20


<210>  24522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24522
aaagggaaau uugaaagucu                                                   20


<210>  24523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24523
uuuggauuga cugauauaaa                                                   20


<210>  24524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24524
auccaaaaga cuuucaaauu                                                   20


<210>  24525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24525
uugauuugaa aucuuucuuu                                                   20


<210>  24526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24526
uuuucaaguu uccaaaggua                                                   20


<210>  24527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24527
caaacaaucc accugccucg                                                   20


<210>  24528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24528
ucaacugcca gucucaaaca                                                   20


<210>  24529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24529
cccuaggcug cccaggcugg                                                   20


<210>  24530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24530
cagcuaacca ggagucuaag                                                   20


<210>  24531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24531
aaggugggag gauugcuuga                                                   20


<210>  24532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24532
gggagguuga ggcugcagug                                                   20


<210>  24533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24533
cauucuguug cccaggaugg                                                   20


<210>  24534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24534
caaaaacaaa aacaguuacu                                                   20


<210>  24535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24535
auucuucuag uaacuguuuu                                                   20


<210>  24536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24536
guaaaauaga aaacaaaaau                                                   20


<210>  24537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24537
caaauuagca auaucaggaa                                                   20


<210>  24538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24538
ucucccucau uccugauauu                                                   20


<210>  24539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24539
uuuuaauauc uauauaaucu                                                   20


<210>  24540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24540
accucggccu cccaaggugc                                                   20


<210>  24541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24541
ggaguuuggg accagccugg                                                   20


<210>  24542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24542
caaacuccug accucaggug                                                   20


<210>  24543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24543
cuacuaaaaa uacaaaaauu                                                   20


<210>  24544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24544
uggugcugug ugccuguaau                                                   20


<210>  24545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24545
cccaggcugg agugcaacgg                                                   20


<210>  24546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24546
ugcucuguca cccaggcugg                                                   20


<210>  24547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24547
uuuuuauuua uuuauuuguu                                                   20


<210>  24548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24548
aauuuauugg cauaaaguug                                                   20


<210>  24549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24549
uucaaggaac ucauccauuu                                                   20


<210>  24550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24550
aaucacaggu aaagguuuuc                                                   20


<210>  24551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24551
gaauugagau auacuguaaa                                                   20


<210>  24552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24552
gcuaggaaau auaaaagugu                                                   20


<210>  24553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24553
acagaaacag aaugugagcu                                                   20


<210>  24554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24554
uugaaaugau agaucauuca                                                   20


<210>  24555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24555
guauuccaca uagauaaggu                                                   20


<210>  24556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24556
gaaauacugc uaaguggcau                                                   20


<210>  24557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24557
acaucaguaa ugaucaacaa                                                   20


<210>  24558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24558
cuuucucuuu aucucuaggu                                                   20


<210>  24559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24559
guuucaugua cauggcucau                                                   20


<210>  24560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24560
aaacaaagcc aagagagagc                                                   20


<210>  24561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24561
caaaaacugg aguuuguuua                                                   20


<210>  24562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24562
cgcacaacaa aaacacaauc                                                   20


<210>  24563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24563
gauuguguuu uuguugugcg                                                   20


<210>  24564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24564
aucucuccug ccccuuuuua                                                   20


<210>  24565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24565
aggauugaag uaucugaagu                                                   20


<210>  24566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24566
cacacuaaau uaggaugaua                                                   20


<210>  24567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24567
agacuuuauu cagauuuucu                                                   20


<210>  24568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24568
ggacuuaagu uaauagcaua                                                   20


<210>  24569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24569
uuuuucuguu ccagaauucc                                                   20


<210>  24570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24570
ugcauggaau ucuggaacag                                                   20


<210>  24571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24571
ugucaccuua ggcuccucuu                                                   20


<210>  24572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24572
ccuuaggcuc cucuugacag                                                   20


<210>  24573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24573
agaggagccu aaggugacau                                                   20


<210>  24574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24574
ucacugcaca gcagaaaaag                                                   20


<210>  24575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24575
gaugucagga ugguggcuga                                                   20


<210>  24576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24576
ggaugguggc ugacgaaugc                                                   20


<210>  24577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24577
gccaccaucc ugacaucuga                                                   20


<210>  24578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24578
cugaggaugu cugcacuuuu                                                   20


<210>  24579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24579
gcacuuuuuu ccuuucugau                                                   20


<210>  24580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24580
uguaugguuu gcaggugcuc                                                   20


<210>  24581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24581
gaaggcgcua uguugacaau                                                   20


<210>  24582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24582
acauagcgcc uucugaccgg                                                   20


<210>  24583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24583
augaagggaa ccgaugguag                                                   20


<210>  24584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24584
cuacaggcac cagagaagcc                                                   20


<210>  24585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24585
caguuuucuu aaccauaaaa                                                   20


<210>  24586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24586
guguaugugu gaggauuaaa                                                   20


<210>  24587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24587
ucacacauac acaauuuaau                                                   20


<210>  24588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24588
uuauuaauaa gaacacuucu                                                   20


<210>  24589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24589
ggacgcuggc uucucuggag                                                   20


<210>  24590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24590
ugaccacaga aagcgugauu                                                   20


<210>  24591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24591
ugucccuaga guggucacug                                                   20


<210>  24592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24592
cuagaguggu cacugucuuc                                                   20


<210>  24593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24593
cugucuucuc ucuccgcuug                                                   20


<210>  24594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24594
ucucucuccg cuugcaauuc                                                   20


<210>  24595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24595
cugcauaagu gagaugcgag                                                   20


<210>  24596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24596
ugccagugag aauaaaagaa                                                   20


<210>  24597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24597
gucuuugcau gagacagggu                                                   20


<210>  24598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24598
uugcaugaga cagggucucg                                                   20


<210>  24599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24599
caugcaaaga cagaccgccc                                                   20


<210>  24600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24600
cgcucaguca cccaggcugg                                                   20


<210>  24601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24601
cccaggcugg agugcagugg                                                   20


<210>  24602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24602
cagcuacuca aggggccaag                                                   20


<210>  24603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24603
ugaacgccug ggcucaagug                                                   20


<210>  24604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24604
gaaaaucuaa aaagagggcu                                                   20


<210>  24605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24605
cauuugccau gaaccaaggc                                                   20


<210>  24606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24606
uuuaaugugu aaguauuguu                                                   20


<210>  24607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24607
agcaauuccu ggaaaaaaaa                                                   20


<210>  24608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24608
gaggacugua ggccauggcc                                                   20


<210>  24609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24609
ucagacacac accaagccac                                                   20


<210>  24610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24610
caggugcucu uccuggcugu                                                   20


<210>  24611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24611
ccuugcuucu uucccauguc                                                   20


<210>  24612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24612
ucuucuuugu uuccagccau                                                   20


<210>  24613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24613
ggcccagcgg gcuggcagcg                                                   20


<210>  24614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24614
cacgugcucu cccacgccuc                                                   20


<210>  24615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24615
cguagccuuc agguccuaga                                                   20


<210>  24616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24616
uagacuuugu cuucucauga                                                   20


<210>  24617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24617
aggaccugaa ggcuacguga                                                   20


<210>  24618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24618
ucucaugagu auggcugugu                                                   20


<210>  24619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24619
gauacccagu gcauuucucu                                                   20


<210>  24620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24620
caggcgguga agcacgugug                                                   20


<210>  24621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24621
agcaagaacu ucauaugugg                                                   20


<210>  24622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24622
ccguucugug aggugcuggc                                                   20


<210>  24623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24623
agaggcugaa gugauuuuug                                                   20


<210>  24624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24624
agggaggcag gaaaggcuuc                                                   20


<210>  24625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24625
gcagccagua ggugaaagag                                                   20


<210>  24626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24626
ccaaucuacu cuuucaccua                                                   20


<210>  24627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24627
caaggggugc caggaagcug                                                   20


<210>  24628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24628
cacucucugg cagcauaaga                                                   20


<210>  24629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24629
ggucaagggg uuguaccuug                                                   20


<210>  24630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24630
agggguugua ccuuguuugg                                                   20


<210>  24631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24631
ucaagagccc cuaauucucu                                                   20


<210>  24632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24632
ggggagugua ucauuuagga                                                   20


<210>  24633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24633
cucuuccuaa augauacacu                                                   20


<210>  24634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24634
ucaccggguc acucuuccua                                                   20


<210>  24635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24635
uccucuaccc cacguccuca                                                   20


<210>  24636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24636
aggugggagu gaguagaccc                                                   20


<210>  24637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24637
acucacuccc accuggacuc                                                   20


<210>  24638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24638
gcggaagcag gggcaagagg                                                   20


<210>  24639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24639
cugggugaug gcagcacgcu                                                   20


<210>  24640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24640
cucacaaucu acgccagucg                                                   20


<210>  24641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24641
aauucgcuuu gcucauuuaa                                                   20


<210>  24642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24642
uuaaaugagc aaagcgaauu                                                   20


<210>  24643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24643
gcaagcuuga aaaucaaaac                                                   20


<210>  24644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24644
ucguaaaacu uguggguuaa                                                   20


<210>  24645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24645
acuuacauca acugcccaug                                                   20


<210>  24646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24646
augaucucuu uaaccguggc                                                   20


<210>  24647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24647
ucccuguccc auccccuagc                                                   20


<210>  24648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24648
cauccccuag cuugagaagc                                                   20


<210>  24649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24649
acauuagaga agggcuucuc                                                   20


<210>  24650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24650
acuucaagcu aguaacgaug                                                   20


<210>  24651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24651
agauggucaa cuucaagcua                                                   20


<210>  24652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24652
ggggggcagg gaccacgggc                                                   20


<210>  24653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24653
cugccccccu gacccagagc                                                   20


<210>  24654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24654
gguaugcccg uggucccugc                                                   20


<210>  24655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24655
ugcauccuuu ucugcaggug                                                   20


<210>  24656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24656
gugguuuaua aguacaccca                                                   20


<210>  24657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24657
cgagcacugu ggguguacuu                                                   20


<210>  24658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24658
agggugccgu cugagcccgu                                                   20


<210>  24659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24659
gagcccguau cauccaacag                                                   20


<210>  24660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24660
cuacuaaaaa auacaaaaau                                                   20


<210>  24661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24661
ggcuggucuu gaacuccuga                                                   20


<210>  24662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24662
ugaacuccug accucaggug                                                   20


<210>  24663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24663
ggaguucaag accagccuga                                                   20


<210>  24664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24664
uucacuuaaa cagaaaaaug                                                   20


<210>  24665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24665
uccauaaauc ucuugugauu                                                   20


<210>  24666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24666
caaaaauaaa auaaaauaag                                                   20


<210>  24667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24667
ugcuuucacc caugcuagag                                                   20


<210>  24668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24668
ugccacugua cucuagcaug                                                   20


<210>  24669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24669
caaacuccug accucaggug                                                   20


<210>  24670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24670
ggaguuugag accagcccaa                                                   20


<210>  24671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24671
gggcacagug gcucaugccu                                                   20


<210>  24672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24672
cgaacuccug aucucaggug                                                   20


<210>  24673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24673
cuacuaaaaa uacaaaaauu                                                   20


<210>  24674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24674
cucaggcugg aaugcagugg                                                   20


<210>  24675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24675
cacucugucg cucaggcugg                                                   20


<210>  24676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24676
caaaaaauaa aaaugaaaua                                                   20


<210>  24677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24677
cagcacuuug ggaaccugag                                                   20


<210>  24678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24678
caagcaucca ccugccucag                                                   20


<210>  24679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24679
caaacuccug gucucaagca                                                   20


<210>  24680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24680
guacagaaau uagcugggug                                                   20


<210>  24681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24681
cagcuacuug ggagauugag                                                   20


<210>  24682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24682
cccaggcuga agggcagugg                                                   20


<210>  24683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24683
cacuuggucg cccaggcuga                                                   20


<210>  24684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24684
caaaagaaaa acaaaaaaac                                                   20


<210>  24685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24685
auaauagugg uuuguuuuuu                                                   20


<210>  24686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24686
augaucccuc ugcugugcug                                                   20


<210>  24687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24687
aauaccaggu cuugggcccu                                                   20


<210>  24688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24688
ugggcccuua uuuccaucac                                                   20


<210>  24689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24689
accaaacagc auuuccuucu                                                   20


<210>  24690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24690
agugggcuuc aauuauaaag                                                   20


<210>  24691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24691
ccaagagggu ugcauagaaa                                                   20


<210>  24692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24692
cauacuaguc accaagaggg                                                   20


<210>  24693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24693
ggggccagcu gcuacugauc                                                   20


<210>  24694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24694
cagcucagau gucauuucaa                                                   20


<210>  24695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24695
uuucaaaagu cugcucugcc                                                   20


<210>  24696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24696
gcucugcccu cuccaaauug                                                   20


<210>  24697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24697
accuugcccu guuuauguuu                                                   20


<210>  24698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24698
acugcaauuu ggagagggca                                                   20


<210>  24699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24699
gaaauuguca cguacagucu                                                   20


<210>  24700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24700
cguacagucu aucugugugc                                                   20


<210>  24701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24701
aucugugugc uuguuuauuu                                                   20


<210>  24702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24702
cuugcggaag ggugggauag                                                   20


<210>  24703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24703
uggggcacac aucccauaag                                                   20


<210>  24704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24704
uacugucuua ugcucuguug                                                   20


<210>  24705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24705
uaugcucugu ugcagcccag                                                   20


<210>  24706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24706
gcacauagua cuugcuuaaa                                                   20


<210>  24707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24707
gcaauaauga aauugguacc                                                   20


<210>  24708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24708
guuacaugag uuaaaaauau                                                   20


<210>  24709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24709
aaacaguugu aucuuaacgg                                                   20


<210>  24710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24710
ugcuuuuguu ucucaauccg                                                   20


<210>  24711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24711
augggauauc agcaucagca                                                   20


<210>  24712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24712
cugggaaugu ggucuaaacc                                                   20


<210>  24713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24713
aaacccucac uauuaauaug                                                   20


<210>  24714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24714
ggcauagugg cucauaccuu                                                   20


<210>  24715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24715
agcaauccac cugccuuggc                                                   20


<210>  24716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24716
gggucaagca auccaccugc                                                   20


<210>  24717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24717
cagccacucg agaggcugag                                                   20


<210>  24718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24718
uguugagcca agaucgcacc                                                   20


<210>  24719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24719
cacucuguug cccaggcugg                                                   20


<210>  24720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24720
caaaaaaacc aaaauccaga                                                   20


<210>  24721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24721
cuuuggcugc uaugugcaga                                                   20


<210>  24722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24722
ugucauuccc uuauuuaaac                                                   20


<210>  24723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24723
uucccuuauu uaaacucuug                                                   20


<210>  24724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24724
ggaaucucua ucuaaacggc                                                   20


<210>  24725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24725
auggcucugu caccucagac                                                   20


<210>  24726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24726
ccucagacac ccugcauuga                                                   20


<210>  24727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24727
gaggugacag agccauugac                                                   20


<210>  24728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24728
augcagggug ucugagguga                                                   20


<210>  24729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24729
gauuagaguc agguuuuucu                                                   20


<210>  24730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24730
gguuuuucuu ccuccugaug                                                   20


<210>  24731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24731
cuuccuuagg gagguuuccc                                                   20


<210>  24732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24732
ggcaacaagc acggccucag                                                   20


<210>  24733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24733
cucugugugu ugggugaauu                                                   20


<210>  24734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24734
cagaucacag gaauucaccc                                                   20


<210>  24735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24735
uacacauucg gcuuuucuuc                                                   20


<210>  24736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24736
cccaacacuu gagcuucauc                                                   20


<210>  24737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24737
cuaaugggau ggggaaaacu                                                   20


<210>  24738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24738
uucuuccagc ucuccuucag                                                   20


<210>  24739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24739
ggcacggcag aagguucacc                                                   20


<210>  24740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24740
cuugcuuguu cgagucaggc                                                   20


<210>  24741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24741
aggagaccuu ggcugcagcu                                                   20


<210>  24742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24742
ccuggacuga uucuucgggu                                                   20


<210>  24743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24743
uuugcaaaau ugccaaaaga                                                   20


<210>  24744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24744
caaacaugcg agugaugcug                                                   20


<210>  24745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24745
guggagggug agggcuucug                                                   20


<210>  24746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24746
ugugggagug cuucuugggg                                                   20


<210>  24747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24747
uaauuuagac uaccaucauu                                                   20


<210>  24748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24748
aaauuacgac auacaacaua                                                   20


<210>  24749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24749
uuaggugccu caaaaauaac                                                   20


<210>  24750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24750
cucuaguacg ccgaaaacaa                                                   20


<210>  24751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24751
ucuucccgca gcuagguuaa                                                   20


<210>  24752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24752
uggcacaguc aucuucccgc                                                   20


<210>  24753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24753
gugagcuuuc uccuaccugc                                                   20


<210>  24754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24754
gaacguccug cagcuaucag                                                   20


<210>  24755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24755
ugcagcuauc agagccuguu                                                   20


<210>  24756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24756
agaaauagug acccugucac                                                   20


<210>  24757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24757
cuauuucugg acauuauaaa                                                   20


<210>  24758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24758
caugcucuac agauuacagg                                                   20


<210>  24759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24759
guccuggguu ugagcccaag                                                   20


<210>  24760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24760
uggguuugag cccaagugac                                                   20


<210>  24761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24761
cuugggcuca aacccaggac                                                   20


<210>  24762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24762
aucugauucc acucuaccca                                                   20


<210>  24763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24763
ucuuuacuag uuauuuuccu                                                   20


<210>  24764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24764
cauuaaggcu uauuuuucag                                                   20


<210>  24765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24765
cccacgggaa gggcuuagau                                                   20


<210>  24766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24766
ugggguuuug gaaugacgaa                                                   20


<210>  24767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24767
uuccaaaacc ccaugacuag                                                   20


<210>  24768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24768
gaggcuguga gagcuccaca                                                   20


<210>  24769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24769
guugaaggca guccccucug                                                   20


<210>  24770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24770
ccucugugau aucucuggcu                                                   20


<210>  24771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24771
gagcucagau gauagauggu                                                   20


<210>  24772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24772
caaacuccug gccucaagca                                                   20


<210>  24773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24773
cacuaucuug cccaggcugg                                                   20


<210>  24774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24774
agcuaauuuu uuuucaguuu                                                   20


<210>  24775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24775
uagcuacuca ggaggcugag                                                   20


<210>  24776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24776
cagccuccug aguagcuagg                                                   20


<210>  24777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24777
cacaggcaaa cauaacucuu                                                   20


<210>  24778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24778
uugcacucca gccuuggcaa                                                   20


<210>  24779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24779
cccggguuca agcgauucuc                                                   20


<210>  24780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24780
ggcuggucuc gaacuccuga                                                   20


<210>  24781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24781
cgaacuccug accucaggug                                                   20


<210>  24782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24782
ggaguucgag accagccuga                                                   20


<210>  24783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24783
aaaauugaaa aaaaaaauag                                                   20


<210>  24784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24784
ugguugcuua cguauuauau                                                   20


<210>  24785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24785
ucucuccagu uucaacccag                                                   20


<210>  24786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24786
uccuccuccu ccccaggucc                                                   20


<210>  24787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24787
ccaacuucau cuguccuccu                                                   20


<210>  24788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24788
ccuagaacuu cgauaggggc                                                   20


<210>  24789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24789
ccagcacugg gucaccuaga                                                   20


<210>  24790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24790
aaucauggag gugggggcua                                                   20


<210>  24791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24791
ccuccaccuc caagaugccu                                                   20


<210>  24792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24792
uguucaaucu ucuuccagau                                                   20


<210>  24793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24793
ggaucuggaa gaagauugaa                                                   20


<210>  24794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24794
gaggaaagcu gaaccuagaa                                                   20


<210>  24795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24795
uuguacaacu uuuuguuuuc                                                   20


<210>  24796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24796
ucucacaccu uccaacuucu                                                   20


<210>  24797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24797
ugaaaaauug uacuaaacac                                                   20


<210>  24798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24798
uccaacuuga guuauccagc                                                   20


<210>  24799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24799
gggcagguug aucuucaggu                                                   20


<210>  24800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24800
guaguacacu uguauccuag                                                   20


<210>  24801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24801
uaggauacaa guguacuaca                                                   20


<210>  24802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24802
aguagcuucc ugagagaaga                                                   20


<210>  24803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24803
uugcccuguu gucuuaaaau                                                   20


<210>  24804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24804
uaaaaucucc aacgugaccc                                                   20


<210>  24805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24805
cguuggagau uuuaagacaa                                                   20


<210>  24806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24806
uccuagauug acucacaucu                                                   20


<210>  24807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24807
aucuaggagg accaacaucc                                                   20


<210>  24808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24808
cuugaugggg ucuugcccug                                                   20


<210>  24809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24809
ugcccuguug cccagguugu                                                   20


<210>  24810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24810
caacuacuug ggagggugag                                                   20


<210>  24811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24811
agcuauuuuc uuuacuuuuu                                                   20


<210>  24812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24812
uacucugucg cccaggcuag                                                   20


<210>  24813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24813
cccaggcuag agugcggugg                                                   20


<210>  24814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24814
cgaacgccug accucaggug                                                   20


<210>  24815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24815
ggcguucgag accagccugg                                                   20


<210>  24816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24816
uuuccucuug agucagcuag                                                   20


<210>  24817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24817
gcuaguaucc cuggaaggaa                                                   20


<210>  24818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24818
ccgguugcag gauaaacaua                                                   20


<210>  24819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24819
ccucccuucc aguccccggu                                                   20


<210>  24820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24820
guccccuccc uuccaguccc                                                   20


<210>  24821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24821
gggugcccuc uuacuuuuug                                                   20


<210>  24822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24822
guccucagcc uauguaaaca                                                   20


<210>  24823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24823
ucagccuaug uaaacaccuc                                                   20


<210>  24824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24824
ucccuccaau ccaaggcagc                                                   20


<210>  24825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24825
cauggcuccu ugggcaaauu                                                   20


<210>  24826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24826
guggcuucaa uaagcuugcu                                                   20


<210>  24827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24827
ccagcaaagc uugcauuuga                                                   20


<210>  24828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24828
guuauguagc ucuuguuacu                                                   20


<210>  24829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24829
acaaaacuuc ggaagcuaaa                                                   20


<210>  24830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24830
gcuaaugucc cuguucuguu                                                   20


<210>  24831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24831
cuguucuguu cuuucuguuc                                                   20


<210>  24832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24832
ggaaaaggaa aaacaaggga                                                   20


<210>  24833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24833
uguaugguau guacauuucc                                                   20


<210>  24834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24834
agacagaaua uuaccaagca                                                   20


<210>  24835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24835
ugaccugggu ggcgguuaca                                                   20


<210>  24836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24836
cugcuccugc cuuccucccc                                                   20


<210>  24837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24837
ugacugcugg cuucuaauuc                                                   20


<210>  24838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24838
ugaccuuggg gaggaaggca                                                   20


<210>  24839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24839
guuuuuaaau ucuguguaca                                                   20


<210>  24840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24840
auguacacag aauuuaaaaa                                                   20


<210>  24841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24841
gguuuauuuu ggucgacauu                                                   20


<210>  24842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24842
acauuaaguu caugagaguc                                                   20


<210>  24843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24843
accaaaauaa accagacaaa                                                   20


<210>  24844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24844
ucuauauuau cguguguauu                                                   20


<210>  24845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24845
caguagcacu gcucgcaaua                                                   20


<210>  24846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24846
uuuggaguac augugcaggu                                                   20


<210>  24847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24847
ucgcuagcac uuggaauugc                                                   20


<210>  24848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24848
aaucucuaca aucccaagaa                                                   20


<210>  24849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24849
gagagcucca aggggccucc                                                   20


<210>  24850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24850
gcacacggug agcuuaaaua                                                   20


<210>  24851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24851
auuuggacuc auacaaugau                                                   20


<210>  24852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24852
aaauagacaa gcacaaugag                                                   20


<210>  24853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24853
caaagaaaaa aaaaaaauca                                                   20


<210>  24854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24854
ugcucuguug ccuaggcugg                                                   20


<210>  24855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24855
cagcuacuug agaagcugag                                                   20


<210>  24856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24856
cuacuaaaaa uacaaacauu                                                   20


<210>  24857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24857
caaacuccug accucaagug                                                   20


<210>  24858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24858
ggaguuugag accaaccugg                                                   20


<210>  24859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24859
gagaugauuc uacuuuguuc                                                   20


<210>  24860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24860
uguggcuggg ggguggggua                                                   20


<210>  24861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24861
uguggcuccu ugucagggag                                                   20


<210>  24862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24862
gggaguccug uggcuggcaa                                                   20


<210>  24863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24863
uguggcuggc aaggagagaa                                                   20


<210>  24864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24864
uguggcuggg uugggaggga                                                   20


<210>  24865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24865
uguggcuggg gucucauccu                                                   20


<210>  24866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24866
cauccugugc cuaacagugu                                                   20


<210>  24867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24867
agaggugccg agaccagcuc                                                   20


<210>  24868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24868
cggcaccucu ggacacuguu                                                   20


<210>  24869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24869
gggagacccu aacccagcag                                                   20


<210>  24870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24870
ccccgacuga gcuggucucg                                                   20


<210>  24871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24871
uuaauuccuc uagcgcugcu                                                   20


<210>  24872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24872
cacagccuuu agagcugaga                                                   20


<210>  24873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24873
uuagcauugu uucuauagau                                                   20


<210>  24874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24874
uuaaggcaca gaucgcucau                                                   20


<210>  24875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24875
acccacaacc uuccagugug                                                   20


<210>  24876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24876
cguguaaauu cccugggagg                                                   20


<210>  24877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24877
guuucucaga ggcuuaucgc                                                   20


<210>  24878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24878
gagcuacgcc ugggcaaaua                                                   20


<210>  24879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24879
ccgacucaua gugcuugcuc                                                   20


<210>  24880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24880
gggacucugu cagagcuacg                                                   20


<210>  24881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24881
uggcucagag cauaguuuug                                                   20


<210>  24882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24882
ccaagauaau gcgacuagcu                                                   20


<210>  24883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24883
cauuaucuug gugacuaugu                                                   20


<210>  24884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24884
ccccuuuuca auuuuaggau                                                   20


<210>  24885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24885
uagaggccca ugagaaagua                                                   20


<210>  24886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24886
uguccaguua aauugcagau                                                   20


<210>  24887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24887
aguuaaauug cagauauuuc                                                   20


<210>  24888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24888
ugagaacuuc gugacauuag                                                   20


<210>  24889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24889
cgaaguucuc aggacuggaa                                                   20


<210>  24890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24890
ugcuaauguc acgaaguucu                                                   20


<210>  24891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24891
uuuguugauu uuuuuuuaac                                                   20


<210>  24892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24892
ccaaauacug ugggcagagu                                                   20


<210>  24893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24893
ucuccgcaau gguggaggcc                                                   20


<210>  24894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24894
ccugagugaa gguuauaaag                                                   20


<210>  24895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24895
auuugcuucu uuauaaccuu                                                   20


<210>  24896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24896
guaaacugcu cuugaguguc                                                   20


<210>  24897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24897
caaauuuggg guacuucagu                                                   20


<210>  24898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24898
aaguagauaa aagaugaagc                                                   20


<210>  24899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24899
agcuccccca ccauucggcg                                                   20


<210>  24900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24900
gccgaauggu gggggagcuu                                                   20


<210>  24901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24901
uucuugagug cuggcagaug                                                   20


<210>  24902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24902
ccagcaugua cucaagauag                                                   20


<210>  24903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24903
aucuugagua caugcuggag                                                   20


<210>  24904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24904
agaagcugag ggaucaucug                                                   20


<210>  24905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24905
cugugacccu gcagaugcag                                                   20


<210>  24906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24906
cagagaccca ugcgggcuca                                                   20


<210>  24907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24907
cugggcacgg cugcaucugc                                                   20


<210>  24908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24908
gccacccagg gccuggcccu                                                   20


<210>  24909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24909
gugucggcca ugacuauggu                                                   20


<210>  24910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24910
gccaugacua uggugagucu                                                   20


<210>  24911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24911
uggccgacac agacagaggg                                                   20


<210>  24912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24912
uguaggcuug agacugugcc                                                   20


<210>  24913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24913
caagccuaca agacucacca                                                   20


<210>  24914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24914
guugacaguu ucuccuguug                                                   20


<210>  24915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24915
acugaccuac agagaacccg                                                   20


<210>  24916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24916
acaugcucgc uucagcacuu                                                   20


<210>  24917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24917
uuauuucaua ucgcacgucc                                                   20


<210>  24918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24918
uuuccagaga gccucacugc                                                   20


<210>  24919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24919
gauguuaaga ugucuugcuu                                                   20


<210>  24920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24920
ugcuuccacc cccacaggcu                                                   20


<210>  24921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24921
aggaugaaca cuccacucug                                                   20


<210>  24922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24922
aggacacaag ccugaaaggc                                                   20


<210>  24923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24923
uugaccugcu gcugcagcaa                                                   20


<210>  24924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24924
cuccgaagcu gccuuucagg                                                   20


<210>  24925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24925
cuccuucugc agagcagcuu                                                   20


<210>  24926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24926
agguaggagc acaggguuua                                                   20


<210>  24927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24927
uucacaugca gggccuagag                                                   20


<210>  24928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24928
gucauucaca ugcagggccu                                                   20


<210>  24929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24929
acaccucuaa cucucgguuc                                                   20


<210>  24930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24930
gcaccuaggg uuggaaacga                                                   20


<210>  24931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24931
ucccucugua ugucccuguc                                                   20


<210>  24932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24932
cugucaccgu gagucaaaug                                                   20


<210>  24933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24933
ccgugaguca aaugcgggug                                                   20


<210>  24934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24934
aaugcgggug augccuccuc                                                   20


<210>  24935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24935
cugagaggcu uagguaacac                                                   20


<210>  24936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24936
cgauaugugu ucauccaccc                                                   20


<210>  24937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24937
aggcacggug guauaugcuc                                                   20


<210>  24938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24938
cuaucuccuu gagugagcau                                                   20


<210>  24939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24939
uuuggggugu cggaacaaaa                                                   20


<210>  24940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24940
gaacaaaaug ucggaacuuc                                                   20


<210>  24941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24941
gaacuucucu uuccaaugca                                                   20


<210>  24942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24942
acugccaauc acaguacauu                                                   20


<210>  24943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24943
ggguuuuuau ugugcuuaau                                                   20


<210>  24944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24944
acuuuugcuc agcuguuuau                                                   20


<210>  24945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24945
caugggauau gacauuuaua                                                   20


<210>  24946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24946
uaucccauga gacucugcuu                                                   20


<210>  24947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24947
ugaguugaua cuuuuguaug                                                   20


<210>  24948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24948
ucaucuauag agauacugaa                                                   20


<210>  24949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24949
gaugcagugu ucaugccugu                                                   20


<210>  24950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24950
caaacuccca gguucaagug                                                   20


<210>  24951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24951
uaaagaaaaa aaucagccaa                                                   20


<210>  24952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24952
cagcuacuug ggaggcugag                                                   20


<210>  24953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24953
caugagccug gaagaucaag                                                   20


<210>  24954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24954
caaaaaaaca aaacugcaaa                                                   20


<210>  24955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24955
caaaacagug ccauuguuag                                                   20


<210>  24956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24956
aacaauggca cuguuuugug                                                   20


<210>  24957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24957
auaaggauug uaaaucucuu                                                   20


<210>  24958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24958
ucuaaguuuu ccuguggucu                                                   20


<210>  24959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24959
gauauacugc uuccaucucc                                                   20


<210>  24960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24960
gauuuagugu auauuuuaua                                                   20


<210>  24961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24961
aguauuucuu auauaauauu                                                   20


<210>  24962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24962
gaugggaaaa gcaaauaauu                                                   20


<210>  24963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24963
ugagccguca cuuaugggca                                                   20


<210>  24964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24964
cuuaugggca cguggaaucu                                                   20


<210>  24965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24965
gauuccacgu gcccauaagu                                                   20


<210>  24966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24966
ucucccaacu cugugccggg                                                   20


<210>  24967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24967
auaaagcucc ugucuucucc                                                   20


<210>  24968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24968
uugcuaaguc ccaggaguga                                                   20


<210>  24969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24969
caggagugaa agggugagac                                                   20


<210>  24970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24970
cacccuuuca cuccugggac                                                   20


<210>  24971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24971
acgcacccac acucgugugc                                                   20


<210>  24972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24972
ugaaaaggcc ugcaggcuuu                                                   20


<210>  24973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24973
uuccaggauu acugcaaucc                                                   20


<210>  24974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24974
cacauccaua cccuuuuuuc                                                   20


<210>  24975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24975
uaagaaaauc agcaauuaag                                                   20


<210>  24976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24976
aaagaagaug gaguaagaua                                                   20


<210>  24977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24977
caugguaauu uaauuaagaa                                                   20


<210>  24978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24978
gcaagauuua uaaaggaaau                                                   20


<210>  24979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24979
aauggguucu cuuacucuaa                                                   20


<210>  24980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24980
caagguuaau ggucaaaugg                                                   20


<210>  24981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24981
uuugaaagag aaugucccaa                                                   20


<210>  24982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24982
agguuauugu gacuggacuc                                                   20


<210>  24983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24983
caauaaccua gacucagaaa                                                   20


<210>  24984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24984
agucacaaua accuagacuc                                                   20


<210>  24985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24985
aaguauaagc ugauuacgua                                                   20


<210>  24986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24986
ugcaggccau cccaagucug                                                   20


<210>  24987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24987
guggcagcua cucaacacua                                                   20


<210>  24988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24988
ggccugcacc ugcuuuugua                                                   20


<210>  24989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24989
ggucuggccu gcaccugcuu                                                   20


<210>  24990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24990
gcaaaccaca gugcacaggu                                                   20


<210>  24991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24991
cacuuuuagc ucuucugaug                                                   20


<210>  24992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24992
gauuuugaaa aaaagaaaca                                                   20


<210>  24993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24993
cacaugauuu ggaauauacu                                                   20


<210>  24994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24994
ccaaccccca ggcugcagag                                                   20


<210>  24995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24995
augggucccc aacccccagg                                                   20


<210>  24996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24996
ccaaccccca ggcugcagag                                                   20


<210>  24997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24997
auggccuguu aggaaccagg                                                   20


<210>  24998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24998
gaucaguggc agcauuagau                                                   20


<210>  24999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  24999
agguugugcg cuccuuauga                                                   20


<210>  25000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25000
cgucuugaaa ccauccccug                                                   20


<210>  25001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25001
ugaaaccauc cccuggcccu                                                   20


<210>  25002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25002
cccaugaaac cagucucugg                                                   20


<210>  25003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25003
cuggugccag aaagguuggg                                                   20


<210>  25004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25004
gguagcucuu ucucaguggc                                                   20


<210>  25005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25005
agcugacucu ccccuccgug                                                   20


<210>  25006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25006
gcuugacaca cauuuaaaaa                                                   20


<210>  25007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25007
ccaguuuugg gaaauagaga                                                   20


<210>  25008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25008
augaaguccu auuaaaaaca                                                   20


<210>  25009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25009
uauuaaaaac aacaaaaaag                                                   20


<210>  25010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25010
gaguuuauaa aaugcauccu                                                   20


<210>  25011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25011
guucauaaac cuagaaacag                                                   20


<210>  25012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25012
uggugcugug uaugauguaa                                                   20


<210>  25013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25013
caacauugug gucuuggugc                                                   20


<210>  25014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25014
ggguuugcag aagcucgggu                                                   20


<210>  25015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25015
ggggcauugg gcagcucacc                                                   20


<210>  25016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25016
gguggccgaa gccguagugg                                                   20


<210>  25017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25017
acucuuacaa uuaacuuugc                                                   20


<210>  25018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25018
gcauuccauc uuccuugcca                                                   20


<210>  25019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25019
caaacuccug ggcugaagcg                                                   20


<210>  25020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25020
cacuuggcca gguugucuca                                                   20


<210>  25021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25021
cuacaaaaaa aaaaaaaaaa                                                   20


<210>  25022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25022
cagcugcuuu ggaggcugag                                                   20


<210>  25023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25023
ccaggcucag ugcagcugcc                                                   20


<210>  25024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25024
caaaauaaau uuaaaaauaa                                                   20


<210>  25025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25025
ucagagggau cugagaguuc                                                   20


<210>  25026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25026
gagggaucug agaguuccuu                                                   20


<210>  25027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25027
ggccaggaag gaacucucag                                                   20


<210>  25028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25028
guccccagcu cugcgucugc                                                   20


<210>  25029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25029
ccagcucugc gucugccucc                                                   20


<210>  25030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25030
gccuccacug cccagucacc                                                   20


<210>  25031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25031
ccuccucucc augcucuugg                                                   20


<210>  25032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25032
ugucuggcau gagagcugcc                                                   20


<210>  25033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25033
ggcaugagag cugccuuugg                                                   20


<210>  25034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25034
ggugccuagc aggcuaugga                                                   20


<210>  25035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25035
gcagaaguuu auccauagcc                                                   20


<210>  25036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25036
guguagugca cagugugugu                                                   20


<210>  25037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25037
gauucucucu aauguggagg                                                   20


<210>  25038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25038
uacugcugcc ucgugugaac                                                   20


<210>  25039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25039
uuuacacgga agaauuuuuu                                                   20


<210>  25040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25040
aguauaacuu uucauuagcg                                                   20


<210>  25041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25041
gcuaaauaau cugagauuuc                                                   20


<210>  25042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25042
uaucuuuaga acuauauauu                                                   20


<210>  25043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25043
cuuucuguga uuugcagcug                                                   20


<210>  25044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25044
uuucaagaaa acaaaaaggu                                                   20


<210>  25045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25045
uguguugaau cuuacugauu                                                   20


<210>  25046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25046
aauacaguau uacaagaaau                                                   20


<210>  25047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25047
uaaauuuuga acgcaucaua                                                   20


<210>  25048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25048
gcagacuuuu uuuguaaagg                                                   20


<210>  25049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25049
gcugaccccg aacauuagaa                                                   20


<210>  25050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25050
cuuuacaaaa aaagucugcu                                                   20


<210>  25051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25051
cuuuugcaac auucagcucu                                                   20


<210>  25052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25052
cagggcagag cugaauguug                                                   20


<210>  25053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25053
uuacaacugc auuccuguca                                                   20


<210>  25054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25054
guuucuguaa guaaaguucu                                                   20


<210>  25055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25055
ggaauauuau uaaguagcuu                                                   20


<210>  25056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25056
acauagugag acccggucuc                                                   20


<210>  25057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25057
cacuauguug accaggcugg                                                   20


<210>  25058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25058
cuaccaaaac aaaacaaaac                                                   20


<210>  25059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25059
cagugagcug uagucaugcc                                                   20


<210>  25060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25060
ugccacugca cuccagccua                                                   20


<210>  25061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25061
cauucuguug ccuaggcugg                                                   20


<210>  25062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25062
uaaaaaaaaa aaguuuccuu                                                   20


<210>  25063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25063
aaauuaaaau aacccaacaa                                                   20


<210>  25064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25064
cuuucuauuu ugaaaucuua                                                   20


<210>  25065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25065
uuuaagauuu caaaauagaa                                                   20


<210>  25066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25066
ugauuugagu auuuaauuga                                                   20


<210>  25067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25067
ucauaguaug agauacuuaa                                                   20


<210>  25068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25068
auauucuuga auuaggagag                                                   20


<210>  25069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25069
caaaaucucu ccuaauucaa                                                   20


<210>  25070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25070
cacgucccaa aaucucuccu                                                   20


<210>  25071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25071
gcguaacuua gucacacguc                                                   20


<210>  25072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25072
cuuuuuccag uggcggugag                                                   20


<210>  25073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25073
ucuucguucu caccgccacu                                                   20


<210>  25074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25074
cagccagaag aggauaaacu                                                   20


<210>  25075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25075
cuuuuaagcc uuuuugguau                                                   20


<210>  25076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25076
ucaaacucuu cuguuauagc                                                   20


<210>  25077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25077
uauaauuugg gcagauuuca                                                   20


<210>  25078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25078
uggagccucu cuucuggugg                                                   20


<210>  25079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25079
ccaggguaau uuccucaaag                                                   20


<210>  25080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25080
gaaguaugau aacuuccaua                                                   20


<210>  25081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25081
uuuaaugaca cucacaugug                                                   20


<210>  25082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25082
uuaaaugaca cuaucaaaau                                                   20


<210>  25083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25083
uaauaugauu uaaaacugaa                                                   20


<210>  25084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25084
agaaaauuaa aagauaauaa                                                   20


<210>  25085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25085
cuuucauuuu auuaucuuuu                                                   20


<210>  25086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25086
uuggagcuau gacaugaaua                                                   20


<210>  25087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25087
uagcuccaau gacacaccag                                                   20


<210>  25088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25088
auaaaccuau auggaaaaag                                                   20


<210>  25089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25089
uuauuuuuag caaacuaaaa                                                   20


<210>  25090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25090
uccuccaagg cuucuucuuc                                                   20


<210>  25091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25091
gcagcucugc cuuaacaggu                                                   20


<210>  25092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25092
acaccagcgg cuaacuagug                                                   20


<210>  25093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25093
gccuuccacc ccuugcccuu                                                   20


<210>  25094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25094
cccugcaccu gguggacagc                                                   20


<210>  25095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25095
accaggugca gggggacgag                                                   20


<210>  25096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25096
ugcuguccac caggugcagg                                                   20


<210>  25097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25097
gugguguuug caucauauau                                                   20


<210>  25098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25098
aaacaucuca ugaguuggau                                                   20


<210>  25099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25099
cacacuguca cccagugcag                                                   20


<210>  25100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25100
cccagugcag auacccagug                                                   20


<210>  25101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25101
cuggagugca guggugugcu                                                   20


<210>  25102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25102
cagcuacuug ggaggcugag                                                   20


<210>  25103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25103
ccacaaaaaa auacaaaaau                                                   20


<210>  25104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25104
ggcuggucuu gaacuccuga                                                   20


<210>  25105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25105
ugaacuccug accucaagug                                                   20


<210>  25106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25106
ggaguucaag accagccuga                                                   20


<210>  25107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25107
uacuuucagu uauagcuaaa                                                   20


<210>  25108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25108
guaagcaugu gagcuuuaua                                                   20


<210>  25109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25109
cuccuggggc aguugggucg                                                   20


<210>  25110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25110
accuuuuugc cauaauuuuu                                                   20


<210>  25111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25111
acaugaagcu guuggcagug                                                   20


<210>  25112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25112
acuaggaaaa uguguuacag                                                   20


<210>  25113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25113
uauucuccug gaagauaaac                                                   20


<210>  25114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25114
agaucuugaa uguggcuugg                                                   20


<210>  25115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25115
acucaucucu cugggguggg                                                   20


<210>  25116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25116
gaaacaacug ucaacucauc                                                   20


<210>  25117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25117
gugaccgccu agcuuugcgc                                                   20


<210>  25118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25118
cagacacgca ggcccucuaa                                                   20


<210>  25119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25119
ggggcgcaaa gcuaggcggu                                                   20


<210>  25120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25120
uuauauauug cuccagcuaa                                                   20


<210>  25121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25121
guuaagaacu ugaacuucgg                                                   20


<210>  25122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25122
ugcauuucag caucuucagg                                                   20


<210>  25123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25123
aauggcgaga gaaaacauuc                                                   20


<210>  25124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25124
ucagccucag ugaaggauga                                                   20


<210>  25125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25125
gcaggucaug acaucaucac                                                   20


<210>  25126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25126
ugacaucauc acagaacagc                                                   20


<210>  25127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25127
ugaccugcug acccuggagu                                                   20


<210>  25128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25128
cagcacacac ugcaggcgga                                                   20


<210>  25129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25129
gccugcagug ugugcuguga                                                   20


<210>  25130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25130
cagcuggcca gauccacuga                                                   20


<210>  25131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25131
agucacagcu ggccagaucc                                                   20


<210>  25132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25132
gcgccguccc aucugacccu                                                   20


<210>  25133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25133
caucugaccc ugccauggac                                                   20


<210>  25134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25134
gaugggacgg cgcugaccug                                                   20


<210>  25135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25135
auggcagggu cagaugggac                                                   20


<210>  25136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25136
caucauucag guccauggca                                                   20


<210>  25137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25137
cccaucagcg acagcuccca                                                   20


<210>  25138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25138
cugaugggcg acgaggccug                                                   20


<210>  25139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25139
gggagcuguc gcugaugggc                                                   20


<210>  25140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25140
gaagggguaa cagcugaauc                                                   20


<210>  25141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25141
ggccccucug cccacuuaca                                                   20


<210>  25142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25142
caaauaaaaa auaaaaaaaa                                                   20


<210>  25143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25143
cacuccauag ugcaguggag                                                   20


<210>  25144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25144
cccaaagugc ugggauuaca                                                   20


<210>  25145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25145
ggaguucgag accagccugg                                                   20


<210>  25146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25146
cgaacuccug accucaagug                                                   20


<210>  25147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25147
cuacuaaaaa uacaaaaauu                                                   20


<210>  25148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25148
guagucccag cuguuaggga                                                   20


<210>  25149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25149
cagcuguuag ggaggcugag                                                   20


<210>  25150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25150
cgaucucggc ucauugcaac                                                   20


<210>  25151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25151
ugcucuguug cccgggcugg                                                   20


<210>  25152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25152
cuacugaaaa uacaaacauu                                                   20


<210>  25153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25153
caaacuccug accuuagaug                                                   20


<210>  25154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25154
ggaguuugag accagccugg                                                   20


<210>  25155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25155
ccagggaaga acucaaaaga                                                   20


<210>  25156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25156
aggucuccag ggaagaacuc                                                   20


<210>  25157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25157
auagggguau uagauaacaa                                                   20


<210>  25158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25158
agcucuccau uaaugaucua                                                   20


<210>  25159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25159
uuuguguuga acacugaggu                                                   20


<210>  25160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25160
uaaugaaaug ugauuaauac                                                   20


<210>  25161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25161
aaaguucuua aaauaaugca                                                   20


<210>  25162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25162
acuaacuuag agaugagaag                                                   20


<210>  25163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25163
aauaauguuu gcuacaaguc                                                   20


<210>  25164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25164
auguugaguu uuauacucca                                                   20


<210>  25165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25165
uggaaucauu gcuaccaccc                                                   20


<210>  25166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25166
cuggcaacca cgauucuucu                                                   20


<210>  25167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25167
ucugaauuug acuacuuugg                                                   20


<210>  25168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25168
aauucagaag acagaaagaa                                                   20


<210>  25169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25169
cacaguauuu guuuuacuua                                                   20


<210>  25170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25170
ccaaagcuca ugcauguugu                                                   20


<210>  25171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25171
auggacacuu guauugcuuc                                                   20


<210>  25172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25172
auggacagag gaauggaaaa                                                   20


<210>  25173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25173
ccaggagcua ucuguacacc                                                   20


<210>  25174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25174
auuguucagu uuuuuuaggu                                                   20


<210>  25175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25175
uguguaauuu accuaaaaaa                                                   20


<210>  25176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25176
acuugaaaug uccuguguaa                                                   20


<210>  25177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25177
uugcaauuua ggagauaacc                                                   20


<210>  25178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25178
aaaagcuuug uccucauauu                                                   20


<210>  25179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25179
ucauauuucc aacuugcugu                                                   20


<210>  25180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25180
ucacaaacaa auuuuacagc                                                   20


<210>  25181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25181
acauuggaau uuuuuuggag                                                   20


<210>  25182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25182
uuuauuucaa ggcacagaaa                                                   20


<210>  25183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25183
cuuggugauc acacuucaaa                                                   20


<210>  25184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25184
aacaccuaaa cgguucaagg                                                   20


<210>  25185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25185
guaccgucua acaccuaaac                                                   20


<210>  25186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25186
aaucugcagg cccaaauacu                                                   20


<210>  25187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25187
acauacccau ggaagaguuc                                                   20


<210>  25188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25188
gaauacaaac cacuuuguag                                                   20


<210>  25189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25189
aggucugaau acaaaccacu                                                   20


<210>  25190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25190
uuugauacug uuuucugagu                                                   20


<210>  25191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25191
uuuucaucag cuauucagaa                                                   20


<210>  25192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25192
cuuaaucuug auuucucugu                                                   20


<210>  25193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25193
cugcaggcag ccuucugaca                                                   20


<210>  25194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25194
gaaggcugcc ugcagugacu                                                   20


<210>  25195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25195
cucaccuugu uuucuugauc                                                   20


<210>  25196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25196
caagccuaug ucccucaccu                                                   20


<210>  25197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25197
ucucaagccu augucccuca                                                   20


<210>  25198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25198
acuuuauugc uuucccaucc                                                   20


<210>  25199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25199
ggggcacacu cucaaaggag                                                   20


<210>  25200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25200
gauuucuugg aucauucauu                                                   20


<210>  25201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25201
cucuucauau uaucuuuuua                                                   20


<210>  25202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25202
ucacuuuuaa uuccucaagg                                                   20


<210>  25203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25203
uugaggaauu aaaagugaag                                                   20


<210>  25204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25204
caucaaucag aauuauagcc                                                   20


<210>  25205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25205
uguagaagac cuuucaugcu                                                   20


<210>  25206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25206
ucuacaggac aagcagaagc                                                   20


<210>  25207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25207
acugccuucu uaccacgccc                                                   20


<210>  25208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25208
cagggcugug gcaggggaua                                                   20


<210>  25209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25209
ugcugccucu gacuugucug                                                   20


<210>  25210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25210
gaggcagcag gacacagggu                                                   20


<210>  25211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25211
guuucugcuu ggccaugguc                                                   20


<210>  25212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25212
cugugagguc aggugugcau                                                   20


<210>  25213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25213
ggugugcaua ugggcacaaa                                                   20


<210>  25214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25214
cauacucaac aauacauuca                                                   20


<210>  25215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25215
uugucuccuu ucuagccuug                                                   20


<210>  25216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25216
ccuuucuagc cuugccgcau                                                   20


<210>  25217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25217
ccuuugaugc ggcaaggcua                                                   20


<210>  25218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25218
aaugucaccu uugaugcggc                                                   20


<210>  25219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25219
acugaugaug acucugcacc                                                   20


<210>  25220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25220
ucaucagugg acuguccaau                                                   20


<210>  25221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25221
auuguguccg ccuuuuaucu                                                   20


<210>  25222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25222
gccuuuuauc ugcuucguuu                                                   20


<210>  25223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25223
gcuugguggc cuguuuuugc                                                   20


<210>  25224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25224
gguuuuguuc auuugaaaac                                                   20


<210>  25225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25225
ggaaccagca cugccaagaa                                                   20


<210>  25226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25226
gcgugaaggc ccuggcccuc                                                   20


<210>  25227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25227
agaggaacuu uauagaguuu                                                   20


<210>  25228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25228
auacugaaau aguuuuuaca                                                   20


<210>  25229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25229
aauaucccaa augaacucaa                                                   20


<210>  25230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25230
caguggcgcu gagucgcacu                                                   20


<210>  25231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25231
cacucagcca ggccaggcau                                                   20


<210>  25232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25232
ugguucccac ucacccugag                                                   20


<210>  25233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25233
acugcugccu cagccagucc                                                   20


<210>  25234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25234
ccaucgcgcc caugcuuacu                                                   20


<210>  25235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25235
gauaauaaau cugauuaaaa                                                   20


<210>  25236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25236
gugguauuga ggacauauug                                                   20


<210>  25237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25237
ucaauaccac agacuuucug                                                   20


<210>  25238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25238
uuucugaauu uggaucuucu                                                   20


<210>  25239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25239
cagacaucuu gaacuacauc                                                   20


<210>  25240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25240
gagacauacu guuccucugu                                                   20


<210>  25241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25241
ccaugaucga uguaguucaa                                                   20


<210>  25242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25242
cacagagaau ggcaguggcu                                                   20


<210>  25243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25243
cgcuuccacg ugggagauug                                                   20


<210>  25244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25244
ucuguuacuu gcaaguuagc                                                   20


<210>  25245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25245
acuaagugaa gaaaugguuc                                                   20


<210>  25246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25246
auuucaaaca aauauucuga                                                   20


<210>  25247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25247
guugaauaug cugggcacgg                                                   20


<210>  25248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25248
ccgugcccag cauauucaac                                                   20


<210>  25249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25249
gauuacaggu gugagucacc                                                   20


<210>  25250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25250
ugaacuccug ggcucaagca                                                   20


<210>  25251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25251
acuauguugc ccauagucuu                                                   20


<210>  25252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25252
cuacagaaaa uuaaaaaaaa                                                   20


<210>  25253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25253
cagcuacucg ggaagcugag                                                   20


<210>  25254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25254
cacucuguug cccaggcuag                                                   20


<210>  25255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25255
caaaaauaau aguaauaaua                                                   20


<210>  25256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25256
caacuggcca gucaacaaga                                                   20


<210>  25257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25257
acaagaguaa aaauuaacug                                                   20


<210>  25258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25258
aauuuguggg auaacucccc                                                   20


<210>  25259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25259
ugccugacag uaauuucucu                                                   20


<210>  25260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25260
ggcaugacau uuuaaaaggg                                                   20


<210>  25261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25261
guugugucuu uuuugagcag                                                   20


<210>  25262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25262
uuuuugagca gaaggaagca                                                   20


<210>  25263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25263
uugugucagc caugcaugug                                                   20


<210>  25264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25264
gccaugcaug ugauggugcc                                                   20


<210>  25265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25265
cuauguacuc cacagcacga                                                   20


<210>  25266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25266
uugguguagg ucccuuguuc                                                   20


<210>  25267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25267
cuuguuccua ccccuggguc                                                   20


<210>  25268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25268
gagauuuauu uagaaguggu                                                   20


<210>  25269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25269
ugguuucaac ucucaaacag                                                   20


<210>  25270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25270
cuuucacaua acugguucuu                                                   20


<210>  25271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25271
cucuucaaca cacaauguuc                                                   20


<210>  25272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25272
agacgcgggu acugaguggg                                                   20


<210>  25273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25273
ugacgguuug agaaccguca                                                   20


<210>  25274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25274
cacucaguac ccgcgucuug                                                   20


<210>  25275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25275
ucuugccuug gaccuugugu                                                   20


<210>  25276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25276
aaggcaagag gacagcaggu                                                   20


<210>  25277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25277
ugagucucug cagcagcagc                                                   20


<210>  25278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25278
cugcagcagc agcuacagug                                                   20


<210>  25279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25279
uaacucacug uagcugcugc                                                   20


<210>  25280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25280
gcacaucgau gaucagcugc                                                   20


<210>  25281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25281
ucaccagcca auaggaacug                                                   20


<210>  25282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25282
aucucugcaa ggguuuccag                                                   20


<210>  25283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25283
cauccauuag auuucaugaa                                                   20


<210>  25284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25284
aucagaaauc cgagugguuu                                                   20


<210>  25285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25285
ucuaccuaaa ccacucggau                                                   20


<210>  25286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25286
cuaaauaaau aauaaaauaa                                                   20


<210>  25287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25287
cccaggcuug aaugcaguag                                                   20


<210>  25288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25288
uagaguucaa agcuucagug                                                   20


<210>  25289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25289
uccugccuca gccucccgau                                                   20


<210>  25290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25290
cacuggcuaa uauuuuuugu                                                   20


<210>  25291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25291
ugcuauguug cccaggcugg                                                   20


<210>  25292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25292
caaacuccug ggcuugauug                                                   20


<210>  25293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25293
ucgucauuua aguauucugg                                                   20


<210>  25294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25294
uuuaaguauu cuggauagug                                                   20


<210>  25295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25295
uaaacuuuua aaaaaaugua                                                   20


<210>  25296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25296
uaccuagguu caguauaaug                                                   20


<210>  25297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25297
cacucuguug ccaggcugaa                                                   20


<210>  25298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25298
cuaucugugg guggagccga                                                   20


<210>  25299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25299
uuugaaauag uauuuauuuu                                                   20


<210>  25300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25300
uauugagucu ggaauuguga                                                   20


<210>  25301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25301
ggaauuguga gaggaaugcc                                                   20


<210>  25302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25302
uuccagggca ccuggaugag                                                   20


<210>  25303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25303
uguuuuagau guuuauuuca                                                   20


<210>  25304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25304
uauggauuua agucuaguaa                                                   20


<210>  25305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25305
aguaauguug aguucuuucu                                                   20


<210>  25306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25306
aauacaagau uauguuuauu                                                   20


<210>  25307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25307
uccauuugcu uggagaugaa                                                   20


<210>  25308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25308
ucaucuccaa gcaaauggau                                                   20


<210>  25309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25309
cacccugggg ucuucaucuc                                                   20


<210>  25310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25310
aaaauuauaa uuaaaaaaac                                                   20


<210>  25311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25311
auuguaaaaa guaaugcacu                                                   20


<210>  25312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25312
aaaauuuuua caaugaaagu                                                   20


<210>  25313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25313
aaauuacaug caauuuugua                                                   20


<210>  25314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25314
gauuacaaaa uugcauguaa                                                   20


<210>  25315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25315
uuguuuugcu augcgguugg                                                   20


<210>  25316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25316
caaaaaaaaa auaaaaaaaa                                                   20


<210>  25317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25317
ugcucuauug uccaggugcu                                                   20


<210>  25318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25318
aggugcuauc ucggcucacu                                                   20


<210>  25319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25319
cccugguuca agcgauucuc                                                   20


<210>  25320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25320
cuacuaaaaa uacaaaaauu                                                   20


<210>  25321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25321
cgaacuucug accccgugau                                                   20


<210>  25322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25322
gaaguucgag accagccugg                                                   20


<210>  25323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25323
ccccaaaugu auccuugugc                                                   20


<210>  25324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25324
cuuaagauuu guguuuucgc                                                   20


<210>  25325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25325
ggaguucgag accagccugg                                                   20


<210>  25326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25326
cgaacuccug accucaagug                                                   20


<210>  25327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25327
cuacuaaaaa uacaaaaauu                                                   20


<210>  25328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25328
gauguggugg cacacgccug                                                   20


<210>  25329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25329
cucucuguug cccagguugg                                                   20


<210>  25330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25330
caaaacaaac aaagauuugu                                                   20


<210>  25331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25331
agaaaauaca aaucuuuguu                                                   20


<210>  25332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25332
uaguauagau ggacuuuugc                                                   20


<210>  25333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25333
aucuauacua ugaccccagu                                                   20


<210>  25334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25334
acacaaaauc uugcaggcaa                                                   20


<210>  25335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25335
ucauuucucu ugaguagauc                                                   20


<210>  25336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25336
gagauuuuag uacaccuguc                                                   20


<210>  25337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25337
cccgaguagu guaccuugua                                                   20


<210>  25338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25338
cucaccuucc agccuuccgc                                                   20


<210>  25339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25339
ccaaugucca uuauaccaca                                                   20


<210>  25340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25340
auuauaccac acuguaugcc                                                   20


<210>  25341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25341
cauucuauga ugcccaggcu                                                   20


<210>  25342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25342
cugccuccca gguucaagug                                                   20


<210>  25343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25343
gccucccagg aagcuggaau                                                   20


<210>  25344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25344
ggccaacaug gugaaacccc                                                   20


<210>  25345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25345
caagcuccug accucaagug                                                   20


<210>  25346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25346
ggagcuugag accagucugg                                                   20


<210>  25347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25347
cacaaguaau caaagaaaug                                                   20


<210>  25348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25348
uauaaaccua uuaaguaaau                                                   20


<210>  25349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25349
ccacaaacaa acaaacaaaa                                                   20


<210>  25350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25350
cgcucuguca cucaggcagg                                                   20


<210>  25351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25351
cucaggcagg aaugcagugg                                                   20


<210>  25352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25352
cccugucucg gccucccaaa                                                   20


<210>  25353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25353
cggccuccca aagugcuggg                                                   20


<210>  25354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25354
ccaugaggaa agagacuuua                                                   20


<210>  25355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25355
cuuuccucau ggagacuuga                                                   20


<210>  25356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25356
gcaagcccca ugaucuucaa                                                   20


<210>  25357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25357
caaacacucc cagauggcaa                                                   20


<210>  25358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25358
gcaaaacugu cccaaacacu                                                   20


<210>  25359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25359
gaaugccagc ugcauuccuu                                                   20


<210>  25360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25360
acagaguacu gagcacagag                                                   20


<210>  25361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25361
guccacagag uacugagcac                                                   20


<210>  25362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25362
uaaaauuuaa ucccuuucua                                                   20


<210>  25363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25363
gucauaaaau uuaaucccuu                                                   20


<210>  25364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25364
ggaguucaag aguucaagaa                                                   20


<210>  25365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25365
cuacuaaaac uacaaaaauu                                                   20


<210>  25366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25366
agguucaagu gauucuccug                                                   20


<210>  25367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25367
cucuguggcc caggccggag                                                   20


<210>  25368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25368
caaaaaaaaa aaaaaaagaa                                                   20


<210>  25369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25369
gagugggugc augagaguga                                                   20


<210>  25370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25370
cucucaugca cccacucgga                                                   20


<210>  25371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25371
ccaaucucag ggucacucuc                                                   20


<210>  25372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25372
cgugcuugaa gaacgccacc                                                   20


<210>  25373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25373
gcugguaacc agagguguug                                                   20


<210>  25374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25374
aucacaggug aguuucaucu                                                   20


<210>  25375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25375
caaagcuguu uuauaaaugu                                                   20


<210>  25376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25376
cauuuauaaa acagcuuugg                                                   20


<210>  25377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25377
uuggucacau uuauaaaaca                                                   20


<210>  25378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25378
caugcaugag aaguuucagg                                                   20


<210>  25379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25379
gcacaauaac cagguaugcu                                                   20


<210>  25380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25380
gcauaccugg uuauugugcu                                                   20


<210>  25381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25381
ggaaaaugcc cuuuccugau                                                   20


<210>  25382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25382
guccuuugau aggauauuau                                                   20


<210>  25383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25383
uuugauagga uauuaucauu                                                   20


<210>  25384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25384
auccucaaaa ugauaauauc                                                   20


<210>  25385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25385
cagcugagug auuguggcag                                                   20


<210>  25386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25386
gcacauggaa uguaauaaac                                                   20


<210>  25387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25387
caaacaaaaa uacaacuguc                                                   20


<210>  25388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25388
guguuauuua ggguuaucca                                                   20


<210>  25389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25389
aauggccaca uauaucccau                                                   20


<210>  25390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25390
cacucaccua agaagcagau                                                   20


<210>  25391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25391
uaucacuucu gcaaucuucu                                                   20


<210>  25392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25392
uuuaaauguu auuuuaaaaa                                                   20


<210>  25393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25393
aaguuuugua aaacacuguu                                                   20


<210>  25394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25394
uuuaguccaa guuuuguaaa                                                   20


<210>  25395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25395
uaauuccuga auaaauaacg                                                   20


<210>  25396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25396
uuuuucaugu aaagacugcu                                                   20


<210>  25397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25397
uuacaugaaa aaagacguua                                                   20


<210>  25398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25398
cuugagcuca gggguucaag                                                   20


<210>  25399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25399
ugaaccccug agcucaagcg                                                   20


<210>  25400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25400
cacucuguag cccaagcugg                                                   20


<210>  25401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25401
caaaaaaaga cacacacaca                                                   20


<210>  25402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25402
uuuuuugaga cagagucuca                                                   20


<210>  25403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25403
ccauguuuuu uuuguuugug                                                   20


<210>  25404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25404
ugaaucuucu ccaagagaga                                                   20


<210>  25405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25405
uuucagaaga ugaauauuua                                                   20


<210>  25406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25406
cccaguucca aacuucagca                                                   20


<210>  25407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25407
agaggccugc ugaaguuugg                                                   20


<210>  25408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25408
auugggucuu gcgugauaga                                                   20


<210>  25409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25409
ugcgugauag auacaaugac                                                   20


<210>  25410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25410
uuguaucuau cacgcaagac                                                   20


<210>  25411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25411
ccguggacaa gacacuguga                                                   20


<210>  25412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25412
acggagacac ucaacaaaac                                                   20


<210>  25413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25413
uguccacgga gacacucaac                                                   20


<210>  25414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25414
auuucuaucc cccauuauag                                                   20


<210>  25415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25415
gccccgaaca cuuuugcugc                                                   20


<210>  25416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25416
caacuuuuaa gugaaacggg                                                   20


<210>  25417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25417
cuauauuuuu guuauuagaa                                                   20


<210>  25418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25418
guuaugcuug guaguagguu                                                   20


<210>  25419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25419
cuauggaaaa uaaccuuuca                                                   20


<210>  25420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25420
cuuucuugau cggucuuacu                                                   20


<210>  25421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25421
uacugacauu guaauaguuu                                                   20


<210>  25422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25422
guaagaccga ucaagaaaga                                                   20


<210>  25423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25423
ucuuacggug aggugcuugu                                                   20


<210>  25424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25424
uacagcucuu acuuauccau                                                   20


<210>  25425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25425
uuuacauucc uggaguaagc                                                   20


<210>  25426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25426
uccuaaauug gcugaauuuu                                                   20


<210>  25427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25427
ggagucggau accagccugg                                                   20


<210>  25428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25428
gauaccagcc uggccaacgu                                                   20


<210>  25429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25429
agccacugca cuccagccug                                                   20


<210>  25430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25430
cgcucuauug cacaggcugg                                                   20


<210>  25431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25431
caaaaaaaaa aaaaaaaaaa                                                   20


<210>  25432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25432
ccugcauugg uaauguauca                                                   20


<210>  25433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25433
agauuauaau uaacucagug                                                   20


<210>  25434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25434
cugaguuaau uauaaucuag                                                   20


<210>  25435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25435
caaaaaaaaa auaauaaaau                                                   20


<210>  25436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25436
cuacuaaaaa uacaaaauua                                                   20


<210>  25437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25437
ggcuggucuc aaacucccaa                                                   20


<210>  25438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25438
caaacuccca accucaggug                                                   20


<210>  25439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25439
aggagggcgg aucaccugag                                                   20


<210>  25440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25440
gcaacauaaa uucuuauuau                                                   20


<210>  25441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25441
gauuucaguu aagaaaaaua                                                   20


<210>  25442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25442
ccagcaaauu aacauuacuu                                                   20


<210>  25443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25443
ggcuggucuc gaacuccuga                                                   20


<210>  25444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25444
cgaacuccug accucgugau                                                   20


<210>  25445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25445
ggaguucgag accagccuga                                                   20


<210>  25446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25446
ggcugggcgc aguagcucac                                                   20


<210>  25447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25447
aauaaaauaa aaaggucugg                                                   20


<210>  25448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25448
ucuauaacau ggaaguauuu                                                   20


<210>  25449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25449
gcaguauggu cuucccuuga                                                   20


<210>  25450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25450
ucccuugauu uguucaaaau                                                   20


<210>  25451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25451
gccacaauaa aaauaaauaa                                                   20


<210>  25452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25452
ggcacuguug uaggcuuggg                                                   20


<210>  25453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25453
gggagacgau gugguaagcu                                                   20


<210>  25454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25454
cccugaccag ccugcagaaa                                                   20


<210>  25455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25455
aaaguaggaa guuguaccau                                                   20


<210>  25456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25456
caccauggua caacuuccua                                                   20


<210>  25457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25457
ucuuuccacu gccuucccag                                                   20


<210>  25458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25458
acaacaguau gacauaaaca                                                   20


<210>  25459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25459
uacuguugua gacaacuauu                                                   20


<210>  25460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25460
uuuaucaauu uggcuuuuug                                                   20


<210>  25461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25461
cacacagcua auauagcaga                                                   20


<210>  25462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25462
cuagucucac acagcuaaua                                                   20


<210>  25463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25463
ucaaguucau uuaagggaau                                                   20


<210>  25464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25464
agcuaaugag aaaagccuuu                                                   20


<210>  25465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25465
caauuaagug aaaaaagguu                                                   20


<210>  25466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25466
ucuccagcau ucaggaauag                                                   20


<210>  25467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25467
ccaaaaucau ucucaguaau                                                   20


<210>  25468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25468
gcaaaugacc aacugauauu                                                   20


<210>  25469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25469
uuugcugaca cacacaagaa                                                   20


<210>  25470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25470
guaugugagg aaggugggaa                                                   20


<210>  25471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25471
ggcacuagac uucacuucug                                                   20


<210>  25472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25472
agugccagac cuaugauuag                                                   20


<210>  25473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25473
acccauauuu ucuuuuuuau                                                   20


<210>  25474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25474
gcaccucagg ugguuggagu                                                   20


<210>  25475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25475
aacuaccaag cauugaacuc                                                   20


<210>  25476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25476
uuucuagggg auugagcccu                                                   20


<210>  25477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25477
ugcuuauuug agguugcaau                                                   20


<210>  25478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25478
uucaauaacu uuuacuacaa                                                   20


<210>  25479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25479
gaccugcccc auuguguauc                                                   20


<210>  25480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25480
gacgugguua guuuuccuga                                                   20


<210>  25481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25481
ggguagcugu cucaucucca                                                   20


<210>  25482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25482
caucuccagu ucagcagaac                                                   20


<210>  25483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25483
uaugcccuag uaaaagcauu                                                   20


<210>  25484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25484
aaugaaggaa ugcuuuuacu                                                   20


<210>  25485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25485
caauacauuu uauaccagcu                                                   20


<210>  25486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25486
uccuuucucu ugcaauucca                                                   20


<210>  25487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25487
auaauuugac uuugcaaaug                                                   20


<210>  25488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25488
aauuauagac aauuuuuaag                                                   20


<210>  25489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25489
gcuuccagag ugccuccacu                                                   20


<210>  25490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25490
aggaagagcu guaccguugg                                                   20


<210>  25491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25491
gaaucauugu ggccauccca                                                   20


<210>  25492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25492
gcuugguucc cauuggaucu                                                   20


<210>  25493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25493
cuguuucaac ucaguaccag                                                   20


<210>  25494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25494
uggagucccu guuucaacuc                                                   20


<210>  25495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25495
uugccaguga uggcuugucc                                                   20


<210>  25496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25496
cuuuagucaa auuucagaug                                                   20


<210>  25497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25497
aauuucagau guuaccuaua                                                   20


<210>  25498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25498
auacauuaua cuuucuuaac                                                   20


<210>  25499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25499
cacagagugg cccuaaucac                                                   20


<210>  25500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25500
uccuugcugg ccacauccuc                                                   20


<210>  25501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25501
auugaaauug auuuugggag                                                   20


<210>  25502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25502
cuuucacgaa acucuccuau                                                   20


<210>  25503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25503
cccuaccuuc uccuccagcc                                                   20


<210>  25504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25504
caaagccauu aucuugccuu                                                   20


<210>  25505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25505
ucccuacagu cccaaagcca                                                   20


<210>  25506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25506
ucacaaccga aguucaguug                                                   20


<210>  25507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25507
ucccagguuu cuuugucuuc                                                   20


<210>  25508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25508
ccaccacaca ccugcccagg                                                   20


<210>  25509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25509
uggaaauugg gaacacagau                                                   20


<210>  25510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25510
ggccaacucu caacauaggg                                                   20


<210>  25511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25511
uaaaugacuu caguucccca                                                   20


<210>  25512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25512
uuuaagaccc uauguugaga                                                   20


<210>  25513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25513
uucccaugcu auuggggugg                                                   20


<210>  25514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25514
gugcccauau cacagccagu                                                   20


<210>  25515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25515
ggccagcccu gggggaccgg                                                   20


<210>  25516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25516
cccagggcug gccagaccuc                                                   20


<210>  25517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25517
uggaugacgu ggcuccugga                                                   20


<210>  25518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25518
uccaggacgu gggcacaaau                                                   20


<210>  25519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25519
aggagccacg ucauccagga                                                   20


<210>  25520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25520
cacuugggug cuggauucau                                                   20


<210>  25521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25521
uuaaggcugu augaauccag                                                   20


<210>  25522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25522
ggaaacccau agucauuaag                                                   20


<210>  25523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25523
cuucuuuauu cucuuuuugc                                                   20


<210>  25524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25524
caaucugagc aauuuuguuc                                                   20


<210>  25525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25525
cauuuugaug uuaaauuuag                                                   20


<210>  25526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25526
cccaaagugc uggaauaaca                                                   20


<210>  25527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25527
cgaacucuug gccucaagug                                                   20


<210>  25528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25528
agagaucaag accauccugg                                                   20


<210>  25529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25529
ugaucucuug accucgugau                                                   20


<210>  25530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25530
cuacuaaaaa uacaaaaaaa                                                   20


<210>  25531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25531
cagcugcucg ggaggcugag                                                   20


<210>  25532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25532
cccaggcugg agugcagugg                                                   20


<210>  25533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25533
cgcucuguca cccaggcugg                                                   20


<210>  25534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25534
caaaaaaaaa auuagauggg                                                   20


<210>  25535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25535
cccaggcugg agugcagcgg                                                   20


<210>  25536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25536
gacucuuucc aaaagaagaa                                                   20


<210>  25537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25537
gacucuguca cccaggcugg                                                   20


<210>  25538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25538
cauuuuuuuc uucuuuugga                                                   20


<210>  25539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25539
cuguuauccc uaagagggaa                                                   20


<210>  25540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25540
ccuuaaaucu ugguuaaugg                                                   20


<210>  25541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25541
uggcuagcau aguuauggag                                                   20


<210>  25542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25542
cugagauugg cagaacauuc                                                   20


<210>  25543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25543
aucuuaaauc cauuguacaa                                                   20


<210>  25544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25544
cuacuaaaac uacaaaaaaa                                                   20


<210>  25545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25545
gguuggucuc aaacuccuga                                                   20


<210>  25546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25546
caaacuccug accugaagug                                                   20


<210>  25547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25547
ggaguuugag accaaccuga                                                   20


<210>  25548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25548
aucuuaggcu gggcguggug                                                   20


<210>  25549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25549
ucuaccuuua aaaaucuccc                                                   20


<210>  25550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25550
ucucccuucu cugcaaacau                                                   20


<210>  25551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25551
cagccucagc ccacagagcu                                                   20


<210>  25552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25552
accucagagc agugggaagc                                                   20


<210>  25553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25553
aggccaagag agccaaagaa                                                   20


<210>  25554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25554
acuacuucag ccauccuucc                                                   20


<210>  25555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25555
uuacaucucu gggcacugcu                                                   20


<210>  25556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25556
ugccugccuu ucccucuuug                                                   20


<210>  25557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25557
ucuucaguug gcuuucagag                                                   20


<210>  25558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25558
cuggguucag uccuuccugc                                                   20


<210>  25559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25559
uuccugccca ccagcacaug                                                   20


<210>  25560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25560
uaggccgucu ucucucuuug                                                   20


<210>  25561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25561
ucucucuuug uagucucugg                                                   20


<210>  25562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25562
cugggccagu gcuguucuag                                                   20


<210>  25563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25563
ugccuggcau agcuauggag                                                   20


<210>  25564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25564
cacuagcugc auuucaaggg                                                   20


<210>  25565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25565
gggcuguucu ccugucuuca                                                   20


<210>  25566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25566
ucagugucua gaugagggac                                                   20


<210>  25567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25567
agaugaggga ccucagagga                                                   20


<210>  25568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25568
cucaucuaga cacugaagac                                                   20


<210>  25569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25569
ucugaggucc cucaucuaga                                                   20


<210>  25570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25570
cuggagcugc aguucaaugu                                                   20


<210>  25571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25571
cggggcagcu ggcuacauug                                                   20


<210>  25572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25572
gacacggugu gaugagcuca                                                   20


<210>  25573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25573
gacauaucca caaaucagcu                                                   20


<210>  25574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25574
uccuccccac aucugccccu                                                   20


<210>  25575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25575
uaucaagcua gaaacagguc                                                   20


<210>  25576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25576
ccacaagucu ucauuuccac                                                   20


<210>  25577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25577
ucauuuccac ucaccaaguc                                                   20


<210>  25578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25578
uuuguuuccc cuacuaaaua                                                   20


<210>  25579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25579
ccaaccucug uuaaaaaccg                                                   20


<210>  25580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25580
gguuuuuaac agagguuggg                                                   20


<210>  25581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25581
cggccuccca aaguucugga                                                   20


<210>  25582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25582
ggagaucgag accauuccgg                                                   20


<210>  25583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25583
cgaucuccug accuugugau                                                   20


<210>  25584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25584
cuacuaaaaa uacaaaaaaa                                                   20


<210>  25585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25585
cagcuaccug ggaggcugau                                                   20


<210>  25586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25586
cccaggcugg agugcaaugg                                                   20


<210>  25587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25587
cgcucugucg cccaggcugg                                                   20


<210>  25588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25588
caaaaacaaa acaaaacaaa                                                   20


<210>  25589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25589
uuacagaagu gugagaacga                                                   20


<210>  25590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25590
cagguauguc uuuacagaag                                                   20


<210>  25591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25591
uggcagaagg ugaaggggaa                                                   20


<210>  25592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25592
cucucucucu cuccuucucu                                                   20


<210>  25593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25593
gagguggggc cuggugggag                                                   20


<210>  25594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25594
ccacccaaau cucaugcuga                                                   20


<210>  25595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25595
uccacagaac cggucccugg                                                   20


<210>  25596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25596
cuggugccaa aaaguuuggg                                                   20


<210>  25597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25597
ccaaacuuuu uggcaccagg                                                   20


<210>  25598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25598
auguacaggu gcaugcauau                                                   20


<210>  25599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25599
agacugauau acuaucucau                                                   20


<210>  25600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25600
ggaccagaag uggcagagaa                                                   20


<210>  25601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25601
uucuguugcc cagcuuggag                                                   20


<210>  25602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25602
ugaucauagc ucacugcggc                                                   20


<210>  25603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25603
caacuacuga gaaggcugag                                                   20


<210>  25604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25604
caaaaaaaaa aaaaaaucaa                                                   20


<210>  25605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25605
cagccugucg cccaggcugg                                                   20


<210>  25606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25606
cccaggcugg aguggguugg                                                   20


<210>  25607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25607
cuacuaaaaa uacaaaaagu                                                   20


<210>  25608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25608
cgaacuugug accucgugau                                                   20


<210>  25609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25609
caaguucgag accagccugg                                                   20


<210>  25610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25610
cugugacucu acgucuucug                                                   20


<210>  25611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25611
cagagacaga aggcagguua                                                   20


<210>  25612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25612
ucuggacauu acuguggaug                                                   20


<210>  25613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25613
agaagacgua gagucacaga                                                   20


<210>  25614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25614
gugagcuugu gacuggugcc                                                   20


<210>  25615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25615
caagcucacu gacuguauga                                                   20


<210>  25616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25616
caauuuaaaa aaaaaagaaa                                                   20


<210>  25617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25617
cagccacucg ggaggcugag                                                   20


<210>  25618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25618
ccaugccugg cuaauuuuuu                                                   20


<210>  25619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25619
cgaucuccug acuucaugau                                                   20


<210>  25620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25620
ggagaucgag accacccugg                                                   20


<210>  25621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25621
gcauuucuuc ccugaugccu                                                   20


<210>  25622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25622
augcacccga uuguagccau                                                   20


<210>  25623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25623
ccuuaaacca uaauaggaug                                                   20


<210>  25624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25624
uagucagcau ggguugccau                                                   20


<210>  25625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25625
gcauggguug ccauaacaaa                                                   20


<210>  25626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25626
aagauccagg acuuucgccu                                                   20


<210>  25627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25627
uggaucuugg acuucccaac                                                   20


<210>  25628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25628
gcccucauga cccagucacc                                                   20


<210>  25629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25629
ugagggcaga ccccucauga                                                   20


<210>  25630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25630
ccucccaaag gccccaccuc                                                   20


<210>  25631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25631
cccaaauuua uacacugaaa                                                   20


<210>  25632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25632
auaguccccc aaauuuauac                                                   20


<210>  25633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25633
uagcucugcu acuuacucac                                                   20


<210>  25634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25634
gucaucuugc cuucacucug                                                   20


<210>  25635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25635
ucuugccuuc acucugcucc                                                   20


<210>  25636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25636
cgauguucua uaugcucuca                                                   20


<210>  25637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25637
acaaauccag auguauucau                                                   20


<210>  25638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25638
cagcugguua ccagcaaagc                                                   20


<210>  25639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25639
cgaacuccaa gcuccaguga                                                   20


<210>  25640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25640
ccucaagaaa uuaaaaaauu                                                   20


<210>  25641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25641
caucuacucu ggaggcugag                                                   20


<210>  25642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25642
cccaggaugg ggugcaauca                                                   20


<210>  25643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25643
cacucgucac ccaggauggg                                                   20


<210>  25644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25644
caaaaaagaa aaaaaaaaug                                                   20


<210>  25645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25645
uggcgucaug gccaacauag                                                   20


<210>  25646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25646
uggccaacau agaaugcccu                                                   20


<210>  25647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25647
cuaccaugua ucauugugug                                                   20


<210>  25648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25648
gaacuguaca uaucaggguc                                                   20


<210>  25649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25649
aagaacaaaa ugagugacau                                                   20


<210>  25650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25650
cucauuuugu ucuuggaccc                                                   20


<210>  25651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25651
cauccgacga aaggggaagg                                                   20


<210>  25652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25652
gaugggacuu agagaagggg                                                   20


<210>  25653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25653
caagaaaggc agugaggcca                                                   20


<210>  25654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25654
cucccuuccc cacgcuguuu                                                   20


<210>  25655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25655
uguagaaaca uaggauuuaa                                                   20


<210>  25656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25656
uuaguuucua auaucuugaa                                                   20


<210>  25657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25657
guguacauca gucauuaguu                                                   20


<210>  25658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25658
gaagcauuuc uaagugccac                                                   20


<210>  25659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25659
gccaguggca cuuagaaaug                                                   20


<210>  25660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25660
aaaauucuga uuggaaaugg                                                   20


<210>  25661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25661
ucugaguugg aggagcuuaa                                                   20


<210>  25662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25662
uccaaacuug ugaaugguuu                                                   20


<210>  25663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25663
gaacagaagg ggcuaggauu                                                   20


<210>  25664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25664
caccuaaauc cuagccccuu                                                   20


<210>  25665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25665
cuucaugcuu ugccaggcuc                                                   20


<210>  25666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25666
cagauagcag aggcagcagc                                                   20


<210>  25667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25667
guacagucuc ccuccagacc                                                   20


<210>  25668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25668
cccuccagac ccauucucac                                                   20


<210>  25669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25669
ggagggagac uguacagaca                                                   20


<210>  25670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25670
cuuggcaccc aggggccagu                                                   20


<210>  25671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25671
caaaaaaaua aauaaauaaa                                                   20


<210>  25672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25672
cacucuguca cccaggcugg                                                   20


<210>  25673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25673
cccaggcugg agugcagugg                                                   20


<210>  25674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25674
cagcuacuca ggaggcugag                                                   20


<210>  25675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25675
ccacuaauaa aaaauacaaa                                                   20


<210>  25676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25676
ugaucuccug accucgugau                                                   20


<210>  25677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25677
ggagaucaag accauccugg                                                   20


<210>  25678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25678
accucagccu cucaaagugc                                                   20


<210>  25679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25679
cuguacccgg ccuauuuauu                                                   20


<210>  25680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25680
auuaaaaaua aauaaauagg                                                   20


<210>  25681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25681
ggaguucaag accaaacugg                                                   20


<210>  25682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25682
ugaacucccg accucgugau                                                   20


<210>  25683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25683
cuacuaaaaa uaccacaaaa                                                   20


<210>  25684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25684
ucccagcuac uugggaggcu                                                   20


<210>  25685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25685
cagcuacuug ggaggcugag                                                   20


<210>  25686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25686
cgcucuaucg cccaggcuag                                                   20


<210>  25687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25687
caaaaaaaaa aaaaaaagaa                                                   20


<210>  25688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25688
ccaugcuaua caguagaucu                                                   20


<210>  25689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25689
auaaaugaaa uuuuguaucc                                                   20


<210>  25690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25690
aggauacaaa auuucauuua                                                   20


<210>  25691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25691
ucuucaccca ggcuggagua                                                   20


<210>  25692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25692
cgaacuccug accucaagug                                                   20


<210>  25693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25693
ggaguucgag accagccugg                                                   20


<210>  25694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25694
auccuuagaa aagagcaucu                                                   20


<210>  25695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25695
aucuuccucc uguacuacag                                                   20


<210>  25696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25696
uuaguuuauu uaauucauca                                                   20


<210>  25697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25697
aaagucuuca aacugaagua                                                   20


<210>  25698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25698
ucaaacugaa guagaauagu                                                   20


<210>  25699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25699
uuaaaacauu uuuacaucau                                                   20


<210>  25700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25700
uugaaucagc ugcuccuaug                                                   20


<210>  25701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25701
auuucucauu acuucuaguu                                                   20


<210>  25702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25702
gaggaaauac uugaauauuu                                                   20


<210>  25703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25703
agaagcuuua aaaauaugca                                                   20


<210>  25704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25704
uguuacaaca aguaaauccu                                                   20


<210>  25705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25705
ugaaagcuac acacgcuaac                                                   20


<210>  25706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25706
aauggauagu ugauguuuuu                                                   20


<210>  25707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25707
uucagcuuug uuuaugauag                                                   20


<210>  25708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25708
cuguaaucaa ucuuagcugu                                                   20


<210>  25709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25709
ggagggaucc guguacaggc                                                   20


<210>  25710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25710
ugcagguacc cucugccuaa                                                   20


<210>  25711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25711
ggaauugugg cucauguuag                                                   20


<210>  25712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25712
gggcauggug agccacuugu                                                   20


<210>  25713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25713
gcguaagaaa cuguucacca                                                   20


<210>  25714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25714
agggauguuu uaguuuuuua                                                   20


<210>  25715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25715
aauuuaauuu uuguuuuugg                                                   20


<210>  25716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25716
ccaauaaugu uuacagaaga                                                   20


<210>  25717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25717
gcucaucuau uagaagcauc                                                   20


<210>  25718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25718
aaaaaagaaa aaaaaaaaac                                                   20


<210>  25719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25719
ugcucugucc ccagguugga                                                   20


<210>  25720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25720
ccagguugga gugcaguggu                                                   20


<210>  25721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25721
cagggcucaa gugauccucc                                                   20


<210>  25722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25722
cagguacuca ggagcugagg                                                   20


<210>  25723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25723
cuacaaaaaa uguaaaaauu                                                   20


<210>  25724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25724
cccuaaguug ccugggcugg                                                   20


<210>  25725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25725
caagcuccug gcuuaaguaa                                                   20


<210>  25726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25726
cccuguccag aaugugggau                                                   20


<210>  25727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25727
agaauguggg augcuuuccu                                                   20


<210>  25728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25728
ucauauuuua caagguuuga                                                   20


<210>  25729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25729
cuuuaagcug caugguucuc                                                   20


<210>  25730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25730
gcucccaaag cagaagacgg                                                   20


<210>  25731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25731
ucugcuuugg gagcugacau                                                   20


<210>  25732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25732
aagaugccag ggaggccaga                                                   20


<210>  25733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25733
uccccgcggu cagcuccugc                                                   20


<210>  25734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25734
gcuccugcug cgcagcuucu                                                   20


<210>  25735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25735
ugcuggaucu uugaguauug                                                   20


<210>  25736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25736
ccacucccca uuucuugugu                                                   20


<210>  25737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25737
ucccugguuu cuugcuuugg                                                   20


<210>  25738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25738
ccacagaacu uuugcagcuc                                                   20


<210>  25739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25739
ucagaagagc ugcaaaaguu                                                   20


<210>  25740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25740
ugagaugaga auuaagauga                                                   20


<210>  25741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25741
aggagagguc agauugcugu                                                   20


<210>  25742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25742
gauugcugug cauauuggag                                                   20


<210>  25743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25743
ugugagauga agagcccagg                                                   20


<210>  25744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25744
aaggaacgag gugauguggu                                                   20


<210>  25745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25745
cugcuggauu uuucuuuccu                                                   20


<210>  25746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25746
accugggugu gcccuaaggc                                                   20


<210>  25747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25747
ugguauuuag auccacucac                                                   20


<210>  25748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25748
gucucuugcc ugcuucugac                                                   20


<210>  25749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25749
cuugccugcu ucugacuucg                                                   20


<210>  25750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25750
gaagcaggca agagacagac                                                   20


<210>  25751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25751
gucucgccuu accuuucuug                                                   20


<210>  25752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25752
cgccuuaccu uucuuguuau                                                   20


<210>  25753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25753
uugguccuga cccauucucu                                                   20


<210>  25754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25754
ugacccauuc ucugagucug                                                   20


<210>  25755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25755
ggaccaaaga caugcauaac                                                   20


<210>  25756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25756
guaaaauaga auugcuguau                                                   20


<210>  25757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25757
aauucacaua ggguugguuc                                                   20


<210>  25758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25758
uauuccuuau acacuaggau                                                   20


<210>  25759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25759
aucauaauca guaucuggua                                                   20


<210>  25760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25760
gcacuggaaa aauauuuugg                                                   20


<210>  25761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25761
gcguguuugu ugucagcacu                                                   20


<210>  25762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25762
auguuugugu cuuugguugu                                                   20


<210>  25763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25763
uugguuguac auuaugagau                                                   20


<210>  25764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25764
cgaucucaua auguacaacc                                                   20


<210>  25765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25765
cgcuggaucu ucagaacagc                                                   20


<210>  25766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25766
ugcagugugg ccagcucuag                                                   20


<210>  25767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25767
uguuuuuucu ccuuggguug                                                   20


<210>  25768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25768
ucugggcuga guucaucuag                                                   20


<210>  25769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25769
cccggaggca cccuggagaa                                                   20


<210>  25770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25770
caggacccaa gucugacucu                                                   20


<210>  25771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25771
ugugacgcaa gcacgugggg                                                   20


<210>  25772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25772
gacucugccu uagccaugaa                                                   20


<210>  25773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25773
gacuuggguc cugugacgca                                                   20


<210>  25774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25774
guuaucaugu auuagcuuag                                                   20


<210>  25775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25775
aagcuaauac augauaacag                                                   20


<210>  25776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25776
uuuauuucuu aacuugaccu                                                   20


<210>  25777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25777
aguuaagaaa uaaaggacuc                                                   20


<210>  25778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25778
guuuugcccc uuuccacuug                                                   20


<210>  25779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25779
caccucccgc cccgcccccu                                                   20


<210>  25780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25780
accccagcuc uguuacuucc                                                   20


<210>  25781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25781
uauucucuga cacagauagu                                                   20


<210>  25782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25782
gagaauauga cugucaaccc                                                   20


<210>  25783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25783
cugacuuauc ucacagaaag                                                   20


<210>  25784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25784
gagacuaucu gugucagaga                                                   20


<210>  25785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25785
gcggcagagc cugaguuaaa                                                   20


<210>  25786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25786
cguagauuuu cuuuuucuuu                                                   20


<210>  25787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25787
ccucacuccc caugggcccc                                                   20


<210>  25788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25788
uuugcaggca cauggaugau                                                   20


<210>  25789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25789
aucauugaug gacauucggg                                                   20


<210>  25790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25790
aucaaugaua gacuggauua                                                   20


<210>  25791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25791
uugcuauugu gacuagugcc                                                   20


<210>  25792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25792
caauagcaaa gacuuggaac                                                   20


<210>  25793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25793
uuaucguaga augauuuaua                                                   20


<210>  25794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25794
aaugguauuu cuaguucuag                                                   20


<210>  25795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25795
agaacuagaa auaccauuug                                                   20


<210>  25796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25796
ggcgauuccu caaaggucua                                                   20


<210>  25797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25797
uccacaauag uugaacuaau                                                   20


<210>  25798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25798
cgaaacaaca gaugcuggag                                                   20


<210>  25799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25799
uuagagaaau gcagaucaaa                                                   20


<210>  25800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25800
guuggcugca uaaaugucuu                                                   20


<210>  25801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25801
ucuuuugcga agugucuguu                                                   20


<210>  25802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25802
guucauaucc uuuguccauu                                                   20


<210>  25803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25803
auuuuuugau gggguuguuu                                                   20


<210>  25804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25804
gauggguaga uugcaaaaau                                                   20


<210>  25805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25805
auuuuggcuu uuguugccau                                                   20


<210>  25806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25806
aaaacaccaa aagcaauggc                                                   20


<210>  25807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25807
uugccuaugc cuauguccug                                                   20


<210>  25808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25808
ugaauguuau ggcccagguu                                                   20


<210>  25809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25809
uaggucuuau guuuaagucu                                                   20


<210>  25810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25810
uauguuuaag ucuuugaucc                                                   20


<210>  25811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25811
uugauccauc uugaguugau                                                   20


<210>  25812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25812
aguuucaguu uucugcaugu                                                   20


<210>  25813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25813
gguuugucaa agaucagaug                                                   20


<210>  25814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25814
aagaucagau gauuguagau                                                   20


<210>  25815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25815
auauaucugu uuugguacca                                                   20


<210>  25816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25816
gguaguguga ugccuccagc                                                   20


<210>  25817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25817
uggcuaugca ggcucuuuuu                                                   20


<210>  25818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25818
gugauagcuu gaugggggga                                                   20


<210>  25819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25819
uauccaugaa cauggaaugu                                                   20


<210>  25820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25820
ucucuuauuu ccuugagcag                                                   20


<210>  25821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25821
uucacauccc uuguaaguug                                                   20


<210>  25822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25822
uccuaggugu uucauucccu                                                   20


<210>  25823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25823
guuauuggug uauaggaaug                                                   20


<210>  25824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25824
caggauacaa aaucaaugug                                                   20


<210>  25825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25825
ucugcaaaca gggacaguuu                                                   20


<210>  25826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25826
cuguuugcag augacaugau                                                   20


<210>  25827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25827
ugugccgguu uucgaaggga                                                   20


<210>  25828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25828
uaaauagcuc uuacuauguu                                                   20


<210>  25829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25829
aaggccuuuu cugcaucugu                                                   20


<210>  25830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25830
gcuucauccc uggaaugcaa                                                   20


<210>  25831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25831
cugccaggcu uugguaucag                                                   20


<210>  25832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25832
aggauggauu cacagccgaa                                                   20


<210>  25833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25833
auucagagau ucagcuuuuu                                                   20


<210>  25834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25834
ugggagggug uaugugucca                                                   20


<210>  25835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25835
aggaauuuau ccauuucuuc                                                   20


<210>  25836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25836
auuugauucu ucucucuuuu                                                   20


<210>  25837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25837
ugcuagcggu cuaccuauuu                                                   20


<210>  25838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25838
accuauuuua uugaucuuuu                                                   20


<210>  25839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25839
cuaucuccuu caguucugcu                                                   20


<210>  25840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25840
ucugcuagcu uuugaauuug                                                   20


<210>  25841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25841
cagagauucu gguauguugu                                                   20


<210>  25842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25842
ucguucucau ugguuuccaa                                                   20


<210>  25843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25843
uucaagagca gguuguucag                                                   20


<210>  25844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25844
gacagacagu uuguugugau                                                   20


<210>  25845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25845
gaccacagug caaucaaauu                                                   20


<210>  25846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25846
gucagaccac agugcaauca                                                   20


<210>  25847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25847
guuuuagaau aagugcaaug                                                   20


<210>  25848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25848
auuagguccg cuugguccag                                                   20


<210>  25849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25849
gcuuggucca gugcugaguu                                                   20


<210>  25850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25850
agugcugagu ucaaguccug                                                   20


<210>  25851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25851
uggauauccu uguuaauuuu                                                   20


<210>  25852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25852
auauuaggca gaucaaugag                                                   20


<210>  25853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25853
cccacuauua ccggguggga                                                   20


<210>  25854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25854
cuuuguaggu cucuaagaac                                                   20


<210>  25855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25855
cuaagaacuu gcuucaugaa                                                   20


<210>  25856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25856
ccuuugaacu uuguugauuu                                                   20


<210>  25857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25857
guuuuaucag agacuaggau                                                   20


<210>  25858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25858
cugauaaaac agacuuuaaa                                                   20


<210>  25859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25859
uugcauguga gaugggucuc                                                   20


<210>  25860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25860
ccugaauaca gcacaccaau                                                   20


<210>  25861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25861
ugacucuuua uccaauuugc                                                   20


<210>  25862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25862
agacccauug gugugcugua                                                   20


<210>  25863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25863
gugucuuuua auuggggcau                                                   20


<210>  25864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25864
uuuaauuggg gcauuuagcc                                                   20


<210>  25865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25865
uuaugauccu aguugguuau                                                   20


<210>  25866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25866
guagucuuua caauuuggca                                                   20


<210>  25867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25867
uuacaauuug gcauguuuuu                                                   20


<210>  25868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25868
ccaccaggcc ugccuuacaa                                                   20


<210>  25869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25869
guaaaggauu uuauuucucg                                                   20


<210>  25870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25870
gaugggcuuc ccuuuguggg                                                   20


<210>  25871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25871
gguuacccac aaagggaagc                                                   20


<210>  25872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25872
ugggguugcu cuucucgagg                                                   20


<210>  25873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25873
gccuugcuag guuggggaag                                                   20


<210>  25874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25874
uuucacauag ucccauauuu                                                   20


<210>  25875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25875
cauauuucuu ggaggcuugg                                                   20


<210>  25876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25876
ucucgcuuua uuucauuaau                                                   20


<210>  25877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25877
aagcuugugu auacuucaca                                                   20


<210>  25878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25878
uuuaagcucu ucucuacacu                                                   20


<210>  25879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25879
aacauuuuuu ucaagguuuu                                                   20


<210>  25880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25880
guaauaacaa acuucuccga                                                   20


<210>  25881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25881
auucaucaaa cucauucucc                                                   20


<210>  25882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25882
uugauguugg ugaccuacgg                                                   20


<210>  25883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25883
ccaacaucaa agaccaaagg                                                   20


<210>  25884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25884
uuuuuguuga uguugaugcu                                                   20


<210>  25885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25885
guuagaagga aaacuaacaa                                                   20


<210>  25886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25886
guuggaguuu gcuggagguc                                                   20


<210>  25887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25887
acuccaggcc cuguuugccu                                                   20


<210>  25888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25888
cagagcacga aggugucugc                                                   20


<210>  25889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25889
gccuguauga gguguuuguu                                                   20


<210>  25890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25890
cccagucagg cuacaugggg                                                   20


<210>  25891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25891
ggcuacaugg gggucaggga                                                   20


<210>  25892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25892
gggacccacu ugaggcaguc                                                   20


<210>  25893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25893
cugaccccca uguagccuga                                                   20


<210>  25894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25894
guucauuauc ggagcuugaa                                                   20


<210>  25895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25895
ggcacguaug uuuaaaucug                                                   20


<210>  25896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25896
gcugccuuuu guucagaugu                                                   20


<210>  25897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25897
accacugcug aggcuagagu                                                   20


<210>  25898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25898
auuucagagu gcugcgcuag                                                   20


<210>  25899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25899
cacgcccaug gggccuugcu                                                   20


<210>  25900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25900
gcugguugug aagacugugg                                                   20


<210>  25901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25901
ucacaaccag cagaccagga                                                   20


<210>  25902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25902
cucauggcuu ccuuuggcuu                                                   20


<210>  25903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25903
cccgaccccu ugugcuuccc                                                   20


<210>  25904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25904
ggggacuucc cuuuccaagc                                                   20


<210>  25905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25905
agcaaguccc agugagauga                                                   20


<210>  25906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25906
cagugagaug aacuagguac                                                   20


<210>  25907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25907
ucugugucga ucucacuggg                                                   20


<210>  25908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25908
aucucacugg gagcuguaga                                                   20


<210>  25909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25909
acagcuccca gugagaucga                                                   20


<210>  25910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25910
ugcucugucg cccaggcuga                                                   20


<210>  25911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25911
cccaggcuga cgugcaucgg                                                   20


<210>  25912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25912
gccugggcga cagagcaaga                                                   20


<210>  25913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25913
cgaacuccug accuugugau                                                   20


<210>  25914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25914
ggaguucgag acuagccugg                                                   20


<210>  25915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25915
gccaccacgc ccagccauau                                                   20


<210>  25916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25916
ccauguauaa cacauuuuag                                                   20


<210>  25917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25917
uaauaauaag guuaaaaaaa                                                   20


<210>  25918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25918
uauauagaaa uggcuguuuu                                                   20


<210>  25919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25919
gugaauguau caaaugcugc                                                   20


<210>  25920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25920
caauuuaaug aagauugaug                                                   20


<210>  25921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25921
uuacaguuaa agguagauuu                                                   20


<210>  25922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25922
ugaaacagca aaaaagauga                                                   20


<210>  25923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25923
uuuagagggg gauauguagg                                                   20


<210>  25924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25924
ggggccaagu gcaaacaaga                                                   20


<210>  25925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25925
gugagggaga uuccucaaaa                                                   20


<210>  25926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25926
ggccaggcuu gagauauaca                                                   20


<210>  25927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25927
cagauaaggc ucaauaguuu                                                   20


<210>  25928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25928
gagcacaagu guagcuggag                                                   20


<210>  25929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25929
ccacaucaag cucaccucuc                                                   20


<210>  25930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25930
gaagaaaacc ugcucauacc                                                   20


<210>  25931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25931
cugugccuuu aaauccugga                                                   20


<210>  25932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25932
agaaugugga auuauuauuu                                                   20


<210>  25933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25933
ucuaauccuu auuuauucca                                                   20


<210>  25934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25934
auaauauaau gcaaaagaaa                                                   20


<210>  25935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25935
gguuuaagac uuuaucugca                                                   20


<210>  25936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25936
uaaaccagac aaaacauaua                                                   20


<210>  25937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25937
cuacaaaaag aaaaacaaaa                                                   20


<210>  25938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25938
guggucccag cuacucgggg                                                   20


<210>  25939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25939
cagcuacucg gggcugaggu                                                   20


<210>  25940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25940
cccaugcugg agugcaaugg                                                   20


<210>  25941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25941
gucacccaug cuggagugca                                                   20


<210>  25942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25942
guuuugggug auuugauaau                                                   20


<210>  25943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25943
guggcuucau aguauuuuua                                                   20


<210>  25944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25944
caaaaaaaaa aaaaagaaag                                                   20


<210>  25945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25945
cgcucugucg ccugcguugg                                                   20


<210>  25946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25946
ccugcguugg agugcaguga                                                   20


<210>  25947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25947
cugcacucca acgcaggcga                                                   20


<210>  25948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25948
cagcuacuca ggaggcugag                                                   20


<210>  25949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25949
cuacuaaaaa uacaaaaaau                                                   20


<210>  25950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25950
caaucuccug accucgugau                                                   20


<210>  25951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25951
ggagauugag accauccugg                                                   20


<210>  25952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25952
cauagcuuac ugaugcucuu                                                   20


<210>  25953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25953
acucuguugu uaaucuguua                                                   20


<210>  25954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25954
agcguauuuu uuuuuuuguu                                                   20


<210>  25955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25955
cacucuguug cccaggcugg                                                   20


<210>  25956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25956
cagcuacucg ggaggcugag                                                   20


<210>  25957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25957
ggaguucaag gccaguuugg                                                   20


<210>  25958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25958
cccaaagugu ugggauuaua                                                   20


<210>  25959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25959
ggccccuguu caguguauau                                                   20


<210>  25960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25960
uuuaaaaaug ucucccugug                                                   20


<210>  25961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25961
cccuguguuu cuguuuagcu                                                   20


<210>  25962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25962
ugcuuuauaa uuugucagau                                                   20


<210>  25963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25963
gauggguugg agcagugcuu                                                   20


<210>  25964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25964
uaaacuaagc acugcuccaa                                                   20


<210>  25965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25965
aaaaaaaaaa uuaguccuaa                                                   20


<210>  25966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25966
ugccuccuaa gcaugguacc                                                   20


<210>  25967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25967
gccugcugag aacagugacu                                                   20


<210>  25968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25968
cuguucucag caggcggacu                                                   20


<210>  25969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25969
cucucgagua cucagcagag                                                   20


<210>  25970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25970
uguuuucucu ucucuggugc                                                   20


<210>  25971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25971
uaugaacugu ggcugucuug                                                   20


<210>  25972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25972
uggucuccuu agauucucag                                                   20


<210>  25973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25973
ccuuagauuc ucagcaccuc                                                   20


<210>  25974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25974
cuccuccuug ugccacagcc                                                   20


<210>  25975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25975
gcccuauggc ugccccaacu                                                   20


<210>  25976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25976
cucgucuccc agggaucacu                                                   20


<210>  25977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25977
cccagggauc acuguccuuc                                                   20


<210>  25978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25978
uucauugcuc auguccagug                                                   20


<210>  25979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25979
agugucuuga ggacucuggg                                                   20


<210>  25980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25980
ugaggacucu ggguuuuguc                                                   20


<210>  25981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25981
ucaagacacu ggacaugagc                                                   20


<210>  25982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25982
guuuuguuuu uugguuugcu                                                   20


<210>  25983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25983
caggcaggag gguaaaccca                                                   20


<210>  25984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25984
cucacccuca uugugcucag                                                   20


<210>  25985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25985
cacucuauua cauuagauau                                                   20


<210>  25986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25986
uuuguuagac aaguagugau                                                   20


<210>  25987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25987
aacaaaggac uuuaacaaau                                                   20


<210>  25988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25988
cacaccacuu uuuguuuuua                                                   20


<210>  25989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25989
gaauugaauu ugucacacac                                                   20


<210>  25990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25990
aauugguguu ggcuuuuagc                                                   20


<210>  25991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25991
aucucaaaaa aaaaaaaaaa                                                   20


<210>  25992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25992
ggcuggucuu gaacuccuga                                                   20


<210>  25993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25993
ugaacuccug accucaagug                                                   20


<210>  25994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25994
ggaguucaag accagccuga                                                   20


<210>  25995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25995
uuuucaagaa ucaagaaggg                                                   20


<210>  25996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25996
uuuuugcaga uuauuuuaag                                                   20


<210>  25997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25997
uaaaauaauc ugcaaaaaug                                                   20


<210>  25998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25998
uagaauuguc uuaaaauaau                                                   20


<210>  25999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  25999
uguucgcagg gcaggaauuc                                                   20


<210>  26000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26000
auuagguauc caguccuguu                                                   20


<210>  26001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26001
ugaaauccaa guuauauaca                                                   20


<210>  26002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26002
guaaaaaguc uugaaaucca                                                   20


<210>  26003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26003
aggauucgua caauaacggg                                                   20


<210>  26004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26004
ucucugaguc gcuuaauguc                                                   20


<210>  26005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26005
cuuaaugucu cacuugucuu                                                   20


<210>  26006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26006
cacuugucuu ucuacagugu                                                   20


<210>  26007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26007
uucuacagug uguugaagag                                                   20


<210>  26008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26008
agaaccaaug auggcaacug                                                   20


<210>  26009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26009
uaacagaaga ggaaaagaau                                                   20


<210>  26010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26010
uacccgaacg ucuuaacaga                                                   20


<210>  26011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26011
agcgcagcac uuuuuggcuc                                                   20


<210>  26012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26012
augauugagc caagaggcca                                                   20


<210>  26013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26013
uccuggggag ugaagggaag                                                   20


<210>  26014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26014
gucacugugg agggcagagg                                                   20


<210>  26015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26015
cuguggaggg cagaggacac                                                   20


<210>  26016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26016
ucugcccucc acagugacag                                                   20


<210>  26017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26017
cucggaguuu cuguuuagaa                                                   20


<210>  26018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26018
uugcuaacau auccaguuau                                                   20


<210>  26019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26019
ucaacaacua cagugaaaaa                                                   20


<210>  26020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26020
caaggccgag cacagcgccu                                                   20


<210>  26021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26021
gcgagggccu gggugaagug                                                   20


<210>  26022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26022
uucuccugcu ccgccugcac                                                   20


<210>  26023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26023
uugguggaag cacgaaagag                                                   20


<210>  26024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26024
gcuguauuca gagaacucua                                                   20


<210>  26025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26025
caagcccauc ucacucacug                                                   20


<210>  26026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26026
gcaaaccaga augcaguuca                                                   20


<210>  26027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26027
ccacccauuc aaagcacagg                                                   20


<210>  26028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26028
ugugcuuuga augggugggg                                                   20


<210>  26029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26029
gcuuuaugac uagaagucuc                                                   20


<210>  26030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26030
uaaagcugac aaaacacaag                                                   20


<210>  26031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26031
cuuuucacuu aaauuuguuu                                                   20


<210>  26032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26032
caaaaaaaaa aaaaacaaau                                                   20


<210>  26033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26033
ugcucugucg cccaggcugg                                                   20


<210>  26034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26034
cccaggcugg agugcagugg                                                   20


<210>  26035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26035
cagcuacucg ggaggcugag                                                   20


<210>  26036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26036
cuacuaaaaa uacaaaaaaa                                                   20


<210>  26037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26037
cgaucuccug accucgugau                                                   20


<210>  26038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26038
ggagaucgag accauccugg                                                   20


<210>  26039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26039
cggccuccca aagugcuggg                                                   20


<210>  26040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26040
uguauacuag gcauuaaaaa                                                   20


<210>  26041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26041
ggagucaagg aaaauaccca                                                   20


<210>  26042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26042
aggaaaauac ccauguucca                                                   20


<210>  26043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26043
guuucaaugc uuucuguaac                                                   20


<210>  26044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26044
uccaaaaaaa ucauguaauu                                                   20


<210>  26045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26045
uuuaaaagau caguaauuua                                                   20


<210>  26046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26046
uaagugagau uugagagaaa                                                   20


<210>  26047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26047
guuuccugua gcagaaaaaa                                                   20


<210>  26048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26048
gagcuuuuuu cugcuacagg                                                   20


<210>  26049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26049
ccucacucgc agaaggcuac                                                   20


<210>  26050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26050
ggcagcugua aacucuaaau                                                   20


<210>  26051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26051
uuaucugaag agggcgaugc                                                   20


<210>  26052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26052
gauugagaaa caacuugaaa                                                   20


<210>  26053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26053
uccagaaagu gucuacccag                                                   20


<210>  26054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26054
acccaguuga agacaaaccu                                                   20


<210>  26055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26055
ucaacugggu agacacuuuc                                                   20


<210>  26056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26056
caaagaaccg ugcagauaag                                                   20


<210>  26057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26057
gugcuagaga ggaaacugga                                                   20


<210>  26058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26058
cagcuccagu uuccucucua                                                   20


<210>  26059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26059
uguacuguuu uaaagcuuuu                                                   20


<210>  26060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26060
ucuggauuca gaucagguuu                                                   20


<210>  26061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26061
cuuuuaucuu ucauccauca                                                   20


<210>  26062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26062
uuuaggguaa uuuguacuaa                                                   20


<210>  26063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26063
gcauguuucc cucaucaguu                                                   20


<210>  26064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26064
gcauccuugc cccagcuccc                                                   20


<210>  26065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26065
agggagcugg ggcaaggaug                                                   20


<210>  26066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26066
cauccacuug ccuccccucc                                                   20


<210>  26067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26067
ugcuaaauuc cauuccuuuu                                                   20


<210>  26068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26068
caguuacugu ccugcuaaau                                                   20


<210>  26069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26069
augugggagc uguguggcuc                                                   20


<210>  26070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26070
agaggggaag cgugcaaaug                                                   20


<210>  26071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26071
ugucccuuca ugaugcacau                                                   20


<210>  26072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26072
cuucaugaug cacauuuucc                                                   20


<210>  26073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26073
caguuaaauc acugcagaug                                                   20


<210>  26074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26074
aaauuuaacu gucauuuuug                                                   20


<210>  26075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26075
uuuuugagcc gugaucuugg                                                   20


<210>  26076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26076
agaaggaaau agagaagugu                                                   20


<210>  26077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26077
gcacuguuac ucaccugaaa                                                   20


<210>  26078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26078
guuucccuag gagaacugag                                                   20


<210>  26079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26079
acacugauuu uccacagugg                                                   20


<210>  26080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26080
cgcucuguca cccaggcugg                                                   20


<210>  26081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26081
cccaggcugg agugcagggg                                                   20


<210>  26082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26082
cagcuacucg ggaggcugag                                                   20


<210>  26083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26083
cuacuaaaaa uacaaaaaau                                                   20


<210>  26084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26084
ccaucuccug accucgugau                                                   20


<210>  26085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26085
ggagauggag accauccugg                                                   20


<210>  26086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26086
ucccagcacu uugggaggcc                                                   20


<210>  26087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26087
gcuuuuaaug aaggaggcau                                                   20


<210>  26088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26088
gaagaaaauc cgucuaaaug                                                   20


<210>  26089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26089
aaaugggcca uugcucuccu                                                   20


<210>  26090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26090
uugggaacuu cuuuuccuuu                                                   20


<210>  26091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26091
aaggaaagga aaagaaguuc                                                   20


<210>  26092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26092
gccuccuagu gucaaaggaa                                                   20


<210>  26093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26093
auggcugugg gcagcagggg                                                   20


<210>  26094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26094
uuguucuuac uagaauggaa                                                   20


<210>  26095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26095
ccuuucuccc aguucuuaag                                                   20


<210>  26096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26096
cuguacugaa ucuuaagaac                                                   20


<210>  26097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26097
guucuagugu ucuauucuug                                                   20


<210>  26098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26098
gguugggaaa gcugacagcu                                                   20


<210>  26099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26099
gcuuucccaa ccugacgggg                                                   20


<210>  26100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26100
cacuguauuc ccugcagcug                                                   20


<210>  26101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26101
ccucucagau gguuggggga                                                   20


<210>  26102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26102
cccaaccauc ugagaggcga                                                   20


<210>  26103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26103
acuccuuugg guaucuuauu                                                   20


<210>  26104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26104
accuucgucc cccaaccauc                                                   20


<210>  26105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26105
ccaaggugua auuuugggua                                                   20


<210>  26106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26106
gaugucucuu ggaauuuauu                                                   20


<210>  26107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26107
cuuggaauuu auuauuuguu                                                   20


<210>  26108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26108
aauuuaucag cugucaagaa                                                   20


<210>  26109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26109
agaauuuuau uuaaaauuua                                                   20


<210>  26110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26110
gauuuccauu uaaagaaaac                                                   20


<210>  26111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26111
ugagauauac auuaauuuuu                                                   20


<210>  26112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26112
guauucauug cacauuucaa                                                   20


<210>  26113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26113
acacaauuaa augcuuugaa                                                   20


<210>  26114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26114
uuaguaauua uuaugcauuu                                                   20


<210>  26115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26115
auuacagguu uauaauuauu                                                   20


<210>  26116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26116
ggaaacauag uguuuauucu                                                   20


<210>  26117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26117
uguaauuaga auaaacacua                                                   20


<210>  26118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26118
ggugccuucu accugcugcc                                                   20


<210>  26119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26119
cugcucugcg cgagggcaca                                                   20


<210>  26120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26120
gugaucuacu cuaaccccac                                                   20


<210>  26121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26121
agguugaauc augaauuauu                                                   20


<210>  26122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26122
aaauggaugu uuuuguuuuu                                                   20


<210>  26123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26123
cagccuuccu uccacuggcc                                                   20


<210>  26124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26124
cguuaccaug ugucacagcc                                                   20


<210>  26125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26125
ucuucggugu cgugaugugc                                                   20


<210>  26126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26126
ucggugucgu gaugugcuug                                                   20


<210>  26127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26127
ugaugugcuu ggcaguguuc                                                   20


<210>  26128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26128
guggcagcca ugugcuucuc                                                   20


<210>  26129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26129
guguauguga agguacuggu                                                   20


<210>  26130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26130
cuaaccagua ccuucacaua                                                   20


<210>  26131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26131
aacuauaucu ccaauaccac                                                   20


<210>  26132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26132
auagggcaau gcuggaagau                                                   20


<210>  26133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26133
gggagggguc aauagggcaa                                                   20


<210>  26134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26134
aaguucaaaa gccuacagau                                                   20


<210>  26135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26135
cugucaaagu ucaaaagccu                                                   20


<210>  26136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26136
uaggaugugu cccugucaaa                                                   20


<210>  26137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26137
uuucgacuca gcgugugugc                                                   20


<210>  26138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26138
aaaagacucu aaguaguagu                                                   20


<210>  26139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26139
gccaaggccc ugccucgcaa                                                   20


<210>  26140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26140
aggaaaccaa acaccuaugc                                                   20


<210>  26141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26141
uuggacagaa aaucaguagg                                                   20


<210>  26142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26142
aaagacccuc caaguccagg                                                   20


<210>  26143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26143
ucugugagag ggucagagag                                                   20


<210>  26144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26144
gagaguauac ccaugcgugc                                                   20


<210>  26145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26145
gugaguauuc cugugugugc                                                   20


<210>  26146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26146
cagggccgga gagaguaugu                                                   20


<210>  26147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26147
cugagagguc agaguguuug                                                   20


<210>  26148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26148
gaguguuugu guguguguca                                                   20


<210>  26149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26149
aagaggguug cauugugccc                                                   20


<210>  26150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26150
gagggugccu cgcgugugug                                                   20


<210>  26151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26151
cugagggguc agagugugcc                                                   20


<210>  26152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26152
gagugugccu gugugugugc                                                   20


<210>  26153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26153
cugagggguc agagugugcc                                                   20


<210>  26154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26154
gagugugccu cugugugugu                                                   20


<210>  26155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26155
cugagggguc agagugugcc                                                   20


<210>  26156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26156
gagugugccu cugugugugc                                                   20


<210>  26157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26157
cugagggggu cagagugugc                                                   20


<210>  26158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26158
gagugugccu cugugugugu                                                   20


<210>  26159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26159
cugagggggu cagagugugc                                                   20


<210>  26160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26160
gagugugccu cugugugugu                                                   20


<210>  26161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26161
cugagggguc aguguuccua                                                   20


<210>  26162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26162
guguuccuau gugcucauga                                                   20


<210>  26163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26163
ugagcacaua ggaacacuga                                                   20


<210>  26164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26164
gagugugccu gugugccaau                                                   20


<210>  26165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26165
uaguagacca guuaauuuau                                                   20


<210>  26166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26166
acuaugacca cauauaaaaa                                                   20


<210>  26167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26167
aaauaaauua acuggucuac                                                   20


<210>  26168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26168
aacacaggag ucaaaauaaa                                                   20


<210>  26169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26169
uauuuugguc uaacacagga                                                   20


<210>  26170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26170
cuuaucuauc uaaugacaga                                                   20


<210>  26171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26171
uuagauagau aagggacuuu                                                   20


<210>  26172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26172
aagccacugg auuauuaugc                                                   20


<210>  26173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26173
uuauugucuu uucagaugaa                                                   20


<210>  26174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26174
uuucagauga aucaaguaga                                                   20


<210>  26175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26175
caagaauaau cuacuugauu                                                   20


<210>  26176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26176
auuugaaaau gauaaaacuu                                                   20


<210>  26177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26177
ccuuuuuuca gaaguggugu                                                   20


<210>  26178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26178
ucacaaaaug aucaguguuc                                                   20


<210>  26179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26179
aagcucuucc ucugaacacu                                                   20


<210>  26180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26180
ccacagccau accggcucug                                                   20


<210>  26181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26181
acgaccucuu uguauuaaga                                                   20


<210>  26182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26182
uggacuaugg gcugcagagc                                                   20


<210>  26183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26183
auguuacuga gacucaucca                                                   20


<210>  26184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26184
caguaacauu gacaccacca                                                   20


<210>  26185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26185
uggauacuuu auugacccgu                                                   20


<210>  26186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26186
auaaaguauc cacgacaguu                                                   20


<210>  26187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26187
cucuccgucg cccaggcugg                                                   20


<210>  26188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26188
cccaggcugg aguguggugg                                                   20


<210>  26189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26189
ggaguucgaa acagcuuggc                                                   20


<210>  26190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26190
ggugaacucc uguggcugug                                                   20


<210>  26191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26191
gagagucacg agaucguuca                                                   20


<210>  26192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26192
cgagaucguu caagauagug                                                   20


<210>  26193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26193
ucguuuugga aaagagggcc                                                   20


<210>  26194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26194
auugauuuuu gguccucguu                                                   20


<210>  26195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26195
agaugguaga aaccuuaaaa                                                   20


<210>  26196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26196
aaauaguggu aaauaaauau                                                   20


<210>  26197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26197
uuuucuuuga gcugauuucu                                                   20


<210>  26198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26198
uugaauucuu augccacuuu                                                   20


<210>  26199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26199
uuuaaaaaga gagauuucug                                                   20


<210>  26200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26200
agcccucacu uauuuuguca                                                   20


<210>  26201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26201
auucuuuuua gcuguuuguc                                                   20


<210>  26202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26202
uugaaucuuc auaaagccau                                                   20


<210>  26203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26203
gaaaaugagc aacuggcaag                                                   20


<210>  26204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26204
uggagaggag uucaucagcc                                                   20


<210>  26205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26205
guuuagaaau gaucacuaau                                                   20


<210>  26206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26206
acaaaggcaa ugagccaccu                                                   20


<210>  26207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26207
aggcuguguu ugaaguuugc                                                   20


<210>  26208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26208
uagagugggg guugcauuag                                                   20


<210>  26209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26209
cccuguccuc gcugggauca                                                   20


<210>  26210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26210
ucgcugggau cacaucuguu                                                   20


<210>  26211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26211
uccagcugaa cugggacaag                                                   20


<210>  26212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26212
caguucagcu ggaagacucu                                                   20


<210>  26213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26213
guuauacuug ucccaguuca                                                   20


<210>  26214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26214
gucuguuaua cuugucccag                                                   20


<210>  26215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26215
cuuggcagca gacuuucuaa                                                   20


<210>  26216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26216
gcugccaaga gacgccuuuc                                                   20


<210>  26217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26217
ugcagcagug ccacaaggag                                                   20


<210>  26218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26218
ucauucuccu uguggcacug                                                   20


<210>  26219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26219
cuuccacuug ucuucauucu                                                   20


<210>  26220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26220
cgacagauag cugacaucau                                                   20


<210>  26221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26221
agacagucgc uuccacuugu                                                   20


<210>  26222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26222
gcuaucuguc gagacagucg                                                   20


<210>  26223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26223
ccgcagccuu ggcuuguugu                                                   20


<210>  26224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26224
uugugaaagg uggguggcug                                                   20


<210>  26225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26225
uaaucugugc cuugauagca                                                   20


<210>  26226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26226
ugggacagcu gacuucauuu                                                   20


<210>  26227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26227
caugacuagc acggagaacu                                                   20


<210>  26228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26228
gcugucccau gacuagcacg                                                   20


<210>  26229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26229
acccaguguu uuauuuggug                                                   20


<210>  26230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26230
gaaaggaaag gaagggaaag                                                   20


<210>  26231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26231
cacucuguca cccaggcuag                                                   20


<210>  26232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26232
cccaggcuag agugcagucg                                                   20


<210>  26233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26233
uguaaucuca cugcaacaac                                                   20


<210>  26234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26234
uugcuacuca ggaggcugag                                                   20


<210>  26235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26235
cgcuguguug cccaggcugg                                                   20


<210>  26236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26236
uuugaucaua gaaauucuga                                                   20


<210>  26237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26237
ggcacaggcc acugugcccc                                                   20


<210>  26238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26238
ccaccacccu ucucugugag                                                   20


<210>  26239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26239
acuuaaaagg caaccucaag                                                   20


<210>  26240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26240
gugguuuuug gcauuugauu                                                   20


<210>  26241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26241
ugaaggcagu aacaucaaua                                                   20


<210>  26242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26242
caagauaaca uuccauuaug                                                   20


<210>  26243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26243
aacuggucuc aagauaacau                                                   20


<210>  26244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26244
uguugucuaa cuggucucaa                                                   20


<210>  26245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26245
aucucaccag aagccaagau                                                   20


<210>  26246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26246
gggucucccu gccuacagau                                                   20


<210>  26247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26247
cccugccuac agaugguuuu                                                   20


<210>  26248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26248
gguauuuacu auguauucag                                                   20


<210>  26249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26249
uucuuuaauc ugcuuugauc                                                   20


<210>  26250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26250
ccuuacccgc aucccaacaa                                                   20


<210>  26251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26251
guccccuuac ccgcauccca                                                   20


<210>  26252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26252
auaccauggc ggcugaucag                                                   20


<210>  26253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26253
gcggugggag uggcauuguu                                                   20


<210>  26254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26254
ccagaucacc aaagcuucuu                                                   20


<210>  26255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26255
gccccccgcc agggccuuug                                                   20


<210>  26256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26256
cacaugggug gcccugcucu                                                   20


<210>  26257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26257
gcaucccuug gcagcaugaa                                                   20


<210>  26258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26258
ucacccugaa aucaccccca                                                   20


<210>  26259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26259
acagccaccc uguccucacc                                                   20


<210>  26260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26260
gcccuaccuu guccacagcc                                                   20


<210>  26261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26261
gagccugucu ggauguagca                                                   20


<210>  26262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26262
ggauguagca guugagaccc                                                   20


<210>  26263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26263
caacugcuac auccagacag                                                   20


<210>  26264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26264
agagacugug gggcaggggg                                                   20


<210>  26265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26265
cucgacaacu ccaggcucau                                                   20


<210>  26266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26266
gcaucugaga uguccacuca                                                   20


<210>  26267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26267
acucacagug gacccagacu                                                   20


<210>  26268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26268
acugugagug gacaucucag                                                   20


<210>  26269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26269
ggguccacug ugaguggaca                                                   20


<210>  26270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26270
cagcuccaag gucagguagg                                                   20


<210>  26271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26271
gguaggugag gggagccagu                                                   20


<210>  26272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26272
cccuccugca caaaaugccu                                                   20


<210>  26273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26273
gcaccuuggg aacuuggccc                                                   20


<210>  26274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26274
uuucaggaac acauucccau                                                   20


<210>  26275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26275
cucuccuguc cuuucaggaa                                                   20


<210>  26276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26276
gcaauggguu aaguuggcag                                                   20


<210>  26277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26277
ugaacugauc cucccuguug                                                   20


<210>  26278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26278
ccugugucau gaacugaucc                                                   20


<210>  26279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26279
gugaacacca caacggcgau                                                   20


<210>  26280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26280
uccaugcagc caauccuaac                                                   20


<210>  26281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26281
aggaugcagg aauccuggag                                                   20


<210>  26282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26282
guuguucccu uguuguaaga                                                   20


<210>  26283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26283
gugcccacca ucaauaagua                                                   20


<210>  26284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26284
aagcuuauac cacagugugu                                                   20


<210>  26285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26285
caaacuccug agcucaagca                                                   20


<210>  26286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26286
cuacuagaaa uacaaaaagu                                                   20


<210>  26287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26287
uggcuaacuc aggaggcuga                                                   20


<210>  26288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26288
cacucugugc cccaggagug                                                   20


<210>  26289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26289
cugcucuucu cacuuaaccc                                                   20


<210>  26290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26290
cuuuguauac acauacaugg                                                   20


<210>  26291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26291
uccaagcguc ccuuuguaua                                                   20


<210>  26292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26292
ccaaaauguu gguaaugauu                                                   20


<210>  26293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26293
gggugcugca gugcuaguug                                                   20


<210>  26294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26294
uuuacagaaa gcauuuauua                                                   20


<210>  26295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26295
uuuagauuuu uauuacauaa                                                   20


<210>  26296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26296
ccuucccuca uuuaaaagca                                                   20


<210>  26297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26297
uuucuuuugg cuuacguaga                                                   20


<210>  26298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26298
aauuccacag augcacauug                                                   20


<210>  26299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26299
augugcaucu guggaauuag                                                   20


<210>  26300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26300
gguagacaug cuuuuacgga                                                   20


<210>  26301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26301
accggacgga gggaggaagg                                                   20


<210>  26302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26302
cuccaaacac aauggugagu                                                   20


<210>  26303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26303
cucgccuggc ucagcagaug                                                   20


<210>  26304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26304
agauucaucu gcugagccag                                                   20


<210>  26305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26305
caguaaucag agccugaaca                                                   20


<210>  26306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26306
gagucaguca guuuggguag                                                   20


<210>  26307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26307
gucaguuugg guagggcuuc                                                   20


<210>  26308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26308
guuuggguag ggcuucuuga                                                   20


<210>  26309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26309
cacucugucg cccaggcugg                                                   20


<210>  26310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26310
cccaggcugg aguacagugu                                                   20


<210>  26311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26311
ugaucucggc ucacugcaag                                                   20


<210>  26312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26312
cagcaacucg ggaggcugag                                                   20


<210>  26313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26313
ugaucuccug accucgugac                                                   20


<210>  26314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26314
ggagaucaag accauccugg                                                   20


<210>  26315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26315
cgaggucagg agaucaagac                                                   20


<210>  26316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26316
cccaggcugg aguacagugg                                                   20


<210>  26317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26317
agguagcgcc acuguacucc                                                   20


<210>  26318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26318
cagcuacucg ggaggcugag                                                   20


<210>  26319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26319
cuacuaaaaa uacaaaaaau                                                   20


<210>  26320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26320
cgaucuccug accuugugau                                                   20


<210>  26321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26321
ggagaucgcg accauccugg                                                   20


<210>  26322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26322
caaagugugc ucccagaaaa                                                   20


<210>  26323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26323
cagcugaaga aaaaaggaag                                                   20


<210>  26324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26324
gugagcacug uucaacugug                                                   20


<210>  26325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26325
acugaagaua uuguucuuuc                                                   20


<210>  26326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26326
ccaucucuua accuauuaau                                                   20


<210>  26327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26327
cgugauguuu cacagucagu                                                   20


<210>  26328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26328
guaagucugg aauaauaccu                                                   20


<210>  26329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26329
ggaauaauac cuggucuugc                                                   20


<210>  26330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26330
ugcuucacuu cugaguuggg                                                   20


<210>  26331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26331
guaucagugu aauuuucuaa                                                   20


<210>  26332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26332
ugcauuaucu auggcucuug                                                   20


<210>  26333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26333
ugaaguucug ucauguucug                                                   20


<210>  26334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26334
uguucugucu cuuguccuca                                                   20


<210>  26335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26335
cuuguccuca guagagaugc                                                   20


<210>  26336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26336
ucaguagaga ugcuacagca                                                   20


<210>  26337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26337
ugggggcagg caguaggggc                                                   20


<210>  26338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26338
gcgugccccu acugccugcc                                                   20


<210>  26339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26339
gggaaguuga aacccaagag                                                   20


<210>  26340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26340
cagauuguca ccaugugcug                                                   20


<210>  26341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26341
ccaugugcug gcaguuuuac                                                   20


<210>  26342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26342
guaauaaaag ucuucucccu                                                   20


<210>  26343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26343
ucucccugca gggcagccug                                                   20


<210>  26344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26344
ucccucauaa auuguuugga                                                   20


<210>  26345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26345
uuggggagcu uccaaacaau                                                   20


<210>  26346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26346
cucuccaccu uugcuagauu                                                   20


<210>  26347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26347
cagccacuua gcagaagcag                                                   20


<210>  26348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26348
ucaguggaga ugcccugugu                                                   20


<210>  26349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26349
aaggagauaa gcccaguaag                                                   20


<210>  26350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26350
cauugaagca gcuggcuaaa                                                   20


<210>  26351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26351
caggaauuua auguaucauc                                                   20


<210>  26352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26352
cucuguguau caccuuccuc                                                   20


<210>  26353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26353
cuuggucucu cuguguauca                                                   20


<210>  26354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26354
acggcgacgg cgcucugcau                                                   20


<210>  26355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26355
ccguggacac agucacuugg                                                   20


<210>  26356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26356
ccuaauucac ugucaucuuu                                                   20


<210>  26357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26357
ucuuuuuugu uucuuggaag                                                   20


<210>  26358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26358
ucuaaaagaa uaccaaccag                                                   20


<210>  26359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26359
gauccacauc uucaagucug                                                   20


<210>  26360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26360
gguaggugaa ucacauuagu                                                   20


<210>  26361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26361
uccuggagug ucucguuccc                                                   20


<210>  26362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26362
cguuccccau ucugcacuau                                                   20


<210>  26363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26363
caugguauca gguguacucu                                                   20


<210>  26364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26364
cucgauggau gaauggauaa                                                   20


<210>  26365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26365
uuuuuuuaag gcugaauaau                                                   20


<210>  26366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26366
gaauguccuu uuuuuaaggc                                                   20


<210>  26367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26367
cccauguugu agcauguguc                                                   20


<210>  26368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26368
uuaaggguca cccauguugu                                                   20


<210>  26369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26369
caaaaggaca aauacuaugu                                                   20


<210>  26370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26370
uuuugugacu ggcuuauuuc                                                   20


<210>  26371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26371
cucauguaag uggaaucaca                                                   20


<210>  26372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26372
ucuuaacuau uuuuaacugu                                                   20


<210>  26373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26373
uggcucaugc cugaaaucca                                                   20


<210>  26374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26374
caaacuccuu ggcucaagca                                                   20


<210>  26375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26375
uaccauguug cugaggcugg                                                   20


<210>  26376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26376
cagcuacuca ggagacugag                                                   20


<210>  26377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26377
ccugaguagc ugggaccaca                                                   20


<210>  26378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26378
cuagugagau guguucaugc                                                   20


<210>  26379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26379
uacucuauag ccgaggcugg                                                   20


<210>  26380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26380
uguuuuguuu uguuuuuuug                                                   20


<210>  26381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26381
agguaaaagg aucacuugaa                                                   20


<210>  26382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26382
caagcuccug gcuucaagug                                                   20


<210>  26383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26383
cgauauguug cucaggcugg                                                   20


<210>  26384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26384
cagcuacuug ggaggcugag                                                   20


<210>  26385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26385
uugaucauuu guaaaaguaa                                                   20


<210>  26386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26386
caagcucaag cgaucacccc                                                   20


<210>  26387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26387
aggcuggucu caagcucaag                                                   20


<210>  26388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26388
cuugcuaugu uguccaggcu                                                   20


<210>  26389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26389
agcuguagug agccaugauc                                                   20


<210>  26390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26390
cgaucucgcc caggcuggag                                                   20


<210>  26391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26391
cuagagaaag aaaaugacaa                                                   20


<210>  26392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26392
uuuucuuucu cuagagacau                                                   20


<210>  26393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26393
uugucauuuu cuuucucuag                                                   20


<210>  26394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26394
uaagaugcca gcugugcagc                                                   20


<210>  26395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26395
aaauuaggac aguguguuuu                                                   20


<210>  26396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26396
uaauuuggac uggcugcuuu                                                   20


<210>  26397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26397
uuuauuuaaa gcaaagcauu                                                   20


<210>  26398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26398
uucuucucuc aagaaaauag                                                   20


<210>  26399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26399
ugguccaaau augaggcaaa                                                   20


<210>  26400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26400
aaauaugagg caaaccaaaa                                                   20


<210>  26401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26401
cgaucaaaga ccuauagaaa                                                   20


<210>  26402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26402
uugaucguga cuccuaagcc                                                   20


<210>  26403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26403
uaauguaaau acugcuugag                                                   20


<210>  26404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26404
caaaaaaaaa aagaaagaaa                                                   20


<210>  26405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26405
cuacuaaaaa uacaaaaaau                                                   20


<210>  26406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26406
cgaacuccug accucaggug                                                   20


<210>  26407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26407
ggaguucgag accagccuca                                                   20


<210>  26408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26408
uacauugauu ucaaaaauga                                                   20


<210>  26409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26409
ucaguguuuc agucauacau                                                   20


<210>  26410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26410
guaagucuuc aguguuucag                                                   20


<210>  26411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26411
ucgguucuga ugaauauaaa                                                   20


<210>  26412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26412
acuucagaug auguaaccau                                                   20


<210>  26413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26413
gucaacuuca gaugauguaa                                                   20


<210>  26414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26414
ccaaauagaa cuaaacaugu                                                   20


<210>  26415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26415
aaaguugucu gaagucuaua                                                   20


<210>  26416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26416
gaagucuaua aaucaugaca                                                   20


<210>  26417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26417
auaaaucaug acaaauuaug                                                   20


<210>  26418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26418
ugauuuauag acuucagaca                                                   20


<210>  26419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26419
uucaguugca gggauaaaac                                                   20


<210>  26420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26420
uaccaacuac ccuugccugc                                                   20


<210>  26421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26421
gcauuguaua uuuaugcauc                                                   20


<210>  26422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26422
cacuuugucg ccuaggcuga                                                   20


<210>  26423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26423
ccuaggcuga agugcagugg                                                   20


<210>  26424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26424
cagcuacuua gaaggcugag                                                   20


<210>  26425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26425
ugcuguguug cccaggcggg                                                   20


<210>  26426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26426
uuaacucuua gcuucaggcg                                                   20


<210>  26427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26427
cccaccacgc ccagucucau                                                   20


<210>  26428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26428
caucucugcu uccuguguua                                                   20


<210>  26429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26429
ugugaaaaca gcccaccaga                                                   20


<210>  26430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26430
ucuucgguca ugugaaaaca                                                   20


<210>  26431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26431
cccauauuac ucaugcaagg                                                   20


<210>  26432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26432
acaugggcca aaugggagac                                                   20


<210>  26433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26433
cccauuuggc ccauguggac                                                   20


<210>  26434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26434
agucucccau uuggcccaug                                                   20


<210>  26435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26435
ccgggaguaa gggagaggag                                                   20


<210>  26436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26436
gcugcaaggg auagcagcac                                                   20


<210>  26437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26437
auuugaggau acucuuggcg                                                   20


<210>  26438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26438
gugcgucagu aucacaaguc                                                   20


<210>  26439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26439
guaucacaag ucuugauauu                                                   20


<210>  26440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26440
ugauauuucc uaugaagaag                                                   20


<210>  26441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26441
cugcacuacu guucuucuuc                                                   20


<210>  26442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26442
gucacugcac uacuguucuu                                                   20


<210>  26443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26443
cccuccgcac aggccauggc                                                   20


<210>  26444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26444
acuaugaaaa uuaaauuuug                                                   20


<210>  26445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26445
gugaagcaua auccgaagau                                                   20


<210>  26446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26446
auuuuaguau guuggucauu                                                   20


<210>  26447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26447
uuuuaauauu uugccaccag                                                   20


<210>  26448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26448
ccuccuggca ucaaauccaa                                                   20


<210>  26449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26449
uuagaaauga ggcugucucc                                                   20


<210>  26450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26450
ugccuuugug ggauaagggu                                                   20


<210>  26451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26451
uucuacaugu ccgagcgauc                                                   20


<210>  26452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26452
gagcgaucuc ugugcagcuc                                                   20


<210>  26453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26453
cugucuuauu gcgcugauuu                                                   20


<210>  26454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26454
uauugcgcug auuuccucuc                                                   20


<210>  26455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26455
aauaggacuu ccagcagaga                                                   20


<210>  26456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26456
uauuggacaa cacuucaaca                                                   20


<210>  26457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26457
cugcuggaag uccuauugga                                                   20


<210>  26458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26458
gcacugucua auuuaguugc                                                   20


<210>  26459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26459
aauuuaguug ccuuuagcca                                                   20


<210>  26460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26460
gauuggauag cuuaauuuau                                                   20


<210>  26461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26461
cauacaggag ccacuaucca                                                   20


<210>  26462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26462
guugagaagc agcuuuacug                                                   20


<210>  26463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26463
aaagauacca gcaggaaacc                                                   20


<210>  26464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26464
ucuuguuucc uuugacugca                                                   20


<210>  26465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26465
aaggaaacaa gaagacagaa                                                   20


<210>  26466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26466
uucaaauaaa ugcagucaaa                                                   20


<210>  26467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26467
ucauuuucgg uuuaugggug                                                   20


<210>  26468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26468
auuucaggcg uggguacuuc                                                   20


<210>  26469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26469
gaauggcacc cuugacuuuu                                                   20


<210>  26470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26470
agggugccau ucugacuagu                                                   20


<210>  26471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26471
uccuguuuac aacauuuggg                                                   20


<210>  26472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26472
aagauagacu gguuuagaaa                                                   20


<210>  26473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26473
aucuuggacc aaaagagagg                                                   20


<210>  26474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26474
auguggcuga auuagagcug                                                   20


<210>  26475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26475
ggccuuguag ccucaacacg                                                   20


<210>  26476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26476
uugaaaauca cggugagcaa                                                   20


<210>  26477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26477
ggauggcagg cagggaagag                                                   20


<210>  26478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26478
ggguggcagg agcugcugcc                                                   20


<210>  26479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26479
uggucguggg ugguggagau                                                   20


<210>  26480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26480
uggguggugg agaugugcca                                                   20


<210>  26481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26481
uggcacaucu ccaccaccca                                                   20


<210>  26482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26482
ugcagccauc cccucugcca                                                   20


<210>  26483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26483
uuuccaaagc gucugugguu                                                   20


<210>  26484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26484
gugguuccac uuuuuggggc                                                   20


<210>  26485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26485
uuucuauagu aauaaaguug                                                   20


<210>  26486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26486
acuuuauuac uauagaaagg                                                   20


<210>  26487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26487
uuuccccaag caugaacuug                                                   20


<210>  26488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26488
cuguguggcg uggagaagag                                                   20


<210>  26489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26489
uagcugaaca agcccagccc                                                   20


<210>  26490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26490
ccgggcacuu ggucccuuuc                                                   20


<210>  26491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26491
cuuucucuuc cccugagucc                                                   20


<210>  26492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26492
cuuuggcucc ccugugccac                                                   20


<210>  26493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26493
cagacugcug cucaucacua                                                   20


<210>  26494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26494
gagacagaaa gaaggcagag                                                   20


<210>  26495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26495
cgaguaguga ugagcagcag                                                   20


<210>  26496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26496
uuguuaggua augguagcua                                                   20


<210>  26497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26497
uaaaaccaag aaacaaccuu                                                   20


<210>  26498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26498
ccgaauuccc acauggagga                                                   20


<210>  26499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26499
gguuggggac aaggagaggg                                                   20


<210>  26500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26500
ccaaccagac acagaggaug                                                   20


<210>  26501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26501
cuuauccaag gccacaaagc                                                   20


<210>  26502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26502
ccacgagaga acaccagcaa                                                   20


<210>  26503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26503
cagccccacc cuguaaaagg                                                   20


<210>  26504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26504
ccuuuuacag gguggggcug                                                   20


<210>  26505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26505
cucagucccc uuuuacaggg                                                   20


<210>  26506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26506
uccugcugcu ucccagcagc                                                   20


<210>  26507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26507
ugcugcuucc cagcagcagc                                                   20


<210>  26508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26508
cugauguguu uucugugagg                                                   20


<210>  26509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26509
gggaaacccu uggaaggagg                                                   20


<210>  26510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26510
ccuccuucca aggguuuccc                                                   20


<210>  26511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26511
ccaugggauu agugguggcu                                                   20


<210>  26512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26512
gccuugcucu ccgcagagag                                                   20


<210>  26513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26513
aguuguuccu cccuccaccu                                                   20


<210>  26514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26514
cuuccaggug gagggaggaa                                                   20


<210>  26515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26515
ccuguuccgc ugggauguua                                                   20


<210>  26516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26516
ccaaguucau ccucauccuc                                                   20


<210>  26517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26517
gcuuccugac gccacauccu                                                   20


<210>  26518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26518
ggaagcagac auaagagggg                                                   20


<210>  26519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26519
cagguuccug aguagcuggg                                                   20


<210>  26520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26520
ggucaaacag agugagaccc                                                   20


<210>  26521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26521
aacagaguga gacccugucu                                                   20


<210>  26522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26522
cacucuguuu gaccagacug                                                   20


<210>  26523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26523
gaaaaaaaaa aaaaaaucca                                                   20


<210>  26524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26524
uaccuuuccu uuccugccug                                                   20


<210>  26525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26525
cucccucugu guacacucca                                                   20


<210>  26526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26526
cucucauccu aggcccucca                                                   20


<210>  26527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26527
cucaguagcu uguggggucu                                                   20


<210>  26528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26528
ucucugucua gccacuuaau                                                   20


<210>  26529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26529
agccacuuaa uugauugugu                                                   20


<210>  26530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26530
auggucucuc guuacuguuu                                                   20


<210>  26531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26531
cucguuacug uuuucucugu                                                   20


<210>  26532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26532
auccccuuug ugaccuuggc                                                   20


<210>  26533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26533
caaaggggau ggaccuacca                                                   20


<210>  26534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26534
augagagcaa cagccaaggu                                                   20


<210>  26535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26535
uuguaguccu ggcauccagc                                                   20


<210>  26536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26536
uggcauccag cuucucgaca                                                   20


<210>  26537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26537
agaagcugga ugccaggacu                                                   20


<210>  26538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26538
cgugucgaga agcuggaugc                                                   20


<210>  26539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26539
ugccaguacc ucagacuugc                                                   20


<210>  26540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26540
gagguacugg caggacaagu                                                   20


<210>  26541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26541
cucuccaggg ccucuucuug                                                   20


<210>  26542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26542
gucucaucuu ccaccugaac                                                   20


<210>  26543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26543
caucuuccac cugaacuucc                                                   20


<210>  26544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26544
cccagguagu agacaguaga                                                   20


<210>  26545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26545
acuaccuggg ugaccuugga                                                   20


<210>  26546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26546
gauucagagc cuguguugac                                                   20


<210>  26547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26547
acacaggcuc ugaaucagac                                                   20


<210>  26548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26548
gucccugcac gugcucugug                                                   20


<210>  26549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26549
cugcacgugc ucuguggccu                                                   20


<210>  26550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26550
ccuccagccc auucugcacu                                                   20


<210>  26551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26551
gcauuguccc cuccagccca                                                   20


<210>  26552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26552
cuggcuccuc cagguuuccu                                                   20


<210>  26553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26553
ugaccugguc ugcauucucu                                                   20


<210>  26554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26554
cgacgaggag uucuaaugcc                                                   20


<210>  26555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26555
gcauucucug agugugcugc                                                   20


<210>  26556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26556
cagguuauag uuuaaggcau                                                   20


<210>  26557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26557
uaaaacaggu aaaaacagag                                                   20


<210>  26558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26558
cgcuccauug cccaggcuag                                                   20


<210>  26559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26559
ccacuaaaaa uacaaaaauu                                                   20


<210>  26560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26560
ggcuggucuc gaacuccuga                                                   20


<210>  26561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26561
cgaacuccug accucaagug                                                   20


<210>  26562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26562
ggaguucgag accagccuga                                                   20


<210>  26563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26563
ugcugccucu cccugcuggg                                                   20


<210>  26564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26564
cugugccuuu gaccuuguuu                                                   20


<210>  26565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26565
aaggcacaga gacaugcaca                                                   20


<210>  26566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26566
ugauuccugg agcccugaga                                                   20


<210>  26567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26567
gccuccccac acacaaugcu                                                   20


<210>  26568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26568
ggugucagga gccugcagag                                                   20


<210>  26569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26569
ggagccugca gagggcacac                                                   20


<210>  26570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26570
aggcucugug ugcccucugc                                                   20


<210>  26571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26571
ugcuuucuca ccuggccucc                                                   20


<210>  26572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26572
cucaguccuu agcaagccca                                                   20


<210>  26573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26573
uuagcaagcc caggagcugu                                                   20


<210>  26574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26574
ugugggggcc ccgcuguggc                                                   20


<210>  26575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26575
gggaacacuc agcgccucga                                                   20


<210>  26576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26576
gaacacagcu ccuggagaag                                                   20


<210>  26577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26577
gcaaugccaa gcccuccagg                                                   20


<210>  26578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26578
acagugagag aggaggaaug                                                   20


<210>  26579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26579
accuccacau uggucggcaa                                                   20


<210>  26580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26580
agaaagcuag cauuccuccu                                                   20


<210>  26581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26581
auuaaauaag ugggauauug                                                   20


<210>  26582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26582
ugaacuccug agcucgugau                                                   20


<210>  26583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26583
cccauacuua cguauucaga                                                   20


<210>  26584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26584
ucucccauac uuacguauuc                                                   20


<210>  26585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26585
agugccacau ggcuacgcga                                                   20


<210>  26586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26586
uugcuuucau cucgguccag                                                   20


<210>  26587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26587
aggguguaga aacugccgcc                                                   20


<210>  26588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26588
gauacugcug cuugucaacc                                                   20


<210>  26589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26589
accacaccga cuaccgcugg                                                   20


<210>  26590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26590
gugugguuga caagcagcag                                                   20


<210>  26591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26591
gcugcacuuc ugcccaccag                                                   20


<210>  26592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26592
ugagacuccc aguaaccuga                                                   20


<210>  26593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26593
caggacaggg ugcugggcug                                                   20


<210>  26594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26594
augaaaggaa uauuaauaug                                                   20


<210>  26595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26595
caauaauaug cuguccauga                                                   20


<210>  26596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26596
agcuaaaggc auucaaaaua                                                   20


<210>  26597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26597
aagaaccugc caaagaaaau                                                   20


<210>  26598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26598
ugcucugugg cuccuacuaa                                                   20


<210>  26599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26599
uuaaauuggu uccauagcca                                                   20


<210>  26600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26600
ggcuauggaa ccaauuuaag                                                   20


<210>  26601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26601
uaaccucauu auaaaguaaa                                                   20


<210>  26602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26602
cagcuuuuau uuccauacau                                                   20


<210>  26603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26603
ccagaacuuc uuuuccccag                                                   20


<210>  26604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26604
aguauccaua cugagcagag                                                   20


<210>  26605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26605
acuguuggga ggcauucuua                                                   20


<210>  26606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26606
ggucauucug uuggaggaga                                                   20


<210>  26607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26607
uucuguugga ggagacagac                                                   20


<210>  26608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26608
ccuccaacag aaugaccaga                                                   20


<210>  26609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26609
gucuccucca acagaaugac                                                   20


<210>  26610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26610
cuggucuguc uccuccaaca                                                   20


<210>  26611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26611
ucacuggucu gucuccucca                                                   20


<210>  26612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26612
uaggccuguu acgaugacug                                                   20


<210>  26613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26613
ucguaacagg ccuaagacau                                                   20


<210>  26614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26614
ccugccccca cagugcucag                                                   20


<210>  26615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26615
gugucuccua guucugugcu                                                   20


<210>  26616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26616
ccuaguucug ugcugcuuua                                                   20


<210>  26617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26617
gaaaaggagu gaucugcuga                                                   20


<210>  26618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26618
ccugaauugg aguaacagaa                                                   20


<210>  26619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26619
ucauucagcc cucugagggc                                                   20


<210>  26620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26620
cagaauuuac cuacauuuac                                                   20


<210>  26621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26621
cgaaacaguc acagaauuua                                                   20


<210>  26622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26622
uggccucagg ugaucugccc                                                   20


<210>  26623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26623
cgaaguccug gccucaggug                                                   20


<210>  26624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26624
cuacugaaaa uaacaaaaau                                                   20


<210>  26625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26625
ccaugcucgg cuaauuuuug                                                   20


<210>  26626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26626
cugcuacuca gaaggcugag                                                   20


<210>  26627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26627
cccaggcuag agugcagugg                                                   20


<210>  26628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26628
cacucuguca cccaggcuag                                                   20


<210>  26629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26629
aagguguccc cgugguggaa                                                   20


<210>  26630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26630
ccguggugga aggaaaaaau                                                   20


<210>  26631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26631
aagaugccca uagagagcag                                                   20


<210>  26632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26632
auggcuaaaa aaagagcagc                                                   20


<210>  26633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26633
agaguaagca gcaggaauuu                                                   20


<210>  26634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26634
ccuggagcca gcucccaucu                                                   20


<210>  26635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26635
uuaugugggu ccugcccuag                                                   20


<210>  26636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26636
ugcccuagcc uagccccucu                                                   20


<210>  26637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26637
auaagagagg ggcuaggcua                                                   20


<210>  26638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26638
cuguggguuu augauucacu                                                   20


<210>  26639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26639
uaccucuugg ugaacuguua                                                   20


<210>  26640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26640
ugccuauacu uuggcgcuug                                                   20


<210>  26641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26641
cuucccagcu caucuuguuc                                                   20


<210>  26642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26642
cccuagauuu gggacauuca                                                   20


<210>  26643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26643
caaaucuagg gugacucaga                                                   20


<210>  26644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26644
acucaaauuc agccccaauu                                                   20


<210>  26645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26645
acugucaacu caaauucagc                                                   20


<210>  26646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26646
acugcucaua uuugaauugc                                                   20


<210>  26647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26647
cacugcgcug gcaggacggc                                                   20


<210>  26648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26648
ugccagcgca gugugacuua                                                   20


<210>  26649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26649
augugaaaac uaacgaacag                                                   20


<210>  26650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26650
guaacagccc cccuccccca                                                   20


<210>  26651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26651
cuucaaacag uucccucuuc                                                   20


<210>  26652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26652
aaccaccaau ccgugcucug                                                   20


<210>  26653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26653
cucuguucag cccauugcag                                                   20


<210>  26654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26654
uccucccacu ucagccucuc                                                   20


<210>  26655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26655
ugaacuccca gccucaaguc                                                   20


<210>  26656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26656
ugcuaggcag cccaggcuag                                                   20


<210>  26657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26657
cuguaguuca gcugcuuggg                                                   20


<210>  26658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26658
ccuaggcugg agcacagugg                                                   20


<210>  26659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26659
ugcuguguca ccuaggcugg                                                   20


<210>  26660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26660
cuggggaaaa aagaaagaaa                                                   20


<210>  26661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26661
ggccccuuuc ggugagcagu                                                   20


<210>  26662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26662
aaaguucugu cgcguguugc                                                   20


<210>  26663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26663
cguguugccc acgcgucggu                                                   20


<210>  26664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26664
guggcucgcu ccuugcaacu                                                   20


<210>  26665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26665
caucaagcua agaauauucu                                                   20


<210>  26666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26666
ccguuaaggc ccuuugccgc                                                   20


<210>  26667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26667
uucccauugc ggcaaagggc                                                   20


<210>  26668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26668
cucggucaga cccugaaggu                                                   20


<210>  26669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26669
gacccugaag gucagagggg                                                   20


<210>  26670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26670
gaccgagcga cguccuuccc                                                   20


<210>  26671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26671
gaggggcagu uugggagugu                                                   20


<210>  26672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26672
acauuuuaac uguauggacu                                                   20


<210>  26673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26673
auacaguuaa aauguugaca                                                   20


<210>  26674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26674
caagguuuau aauucccacg                                                   20


<210>  26675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26675
guguagagug aaauaaccug                                                   20


<210>  26676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26676
guuuuagaac uagaauuaaa                                                   20


<210>  26677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26677
augcaucugu ugcuccuucu                                                   20


<210>  26678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26678
ucuagaagga gcaacagaug                                                   20


<210>  26679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26679
guccagcaca aaguuacuua                                                   20


<210>  26680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26680
agcacaaagu uacuuagucc                                                   20


<210>  26681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26681
ccagaugucu ggagaagagg                                                   20


<210>  26682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26682
ggagaagagg aggauucuga                                                   20


<210>  26683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26683
gaauccuccu cuucuccaga                                                   20


<210>  26684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26684
uaaguuugaa augccuguaa                                                   20


<210>  26685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26685
ccaccucccu caaccccguu                                                   20


<210>  26686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26686
ucuacacagg auguucuccu                                                   20


<210>  26687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26687
augcaagugu caucuacaca                                                   20


<210>  26688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26688
ggguuccaga ggguccaugc                                                   20


<210>  26689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26689
ugccaagcuc caucgaaacu                                                   20


<210>  26690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26690
cagcagaagu aaacauucau                                                   20


<210>  26691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26691
ccaauuauau gucacagcag                                                   20


<210>  26692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26692
cuggauucua aguuggacug                                                   20


<210>  26693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26693
aacuuagaau ccagugacug                                                   20


<210>  26694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26694
gcugcaaaaa cucucacagu                                                   20


<210>  26695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26695
augcacuuac uuuguuuuuu                                                   20


<210>  26696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26696
caaacuccug ggcucaagug                                                   20


<210>  26697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26697
cacaccauag cccaggcuug                                                   20


<210>  26698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26698
cgaacuccca ggcucaagcc                                                   20


<210>  26699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26699
cagccaccug agagacugag                                                   20


<210>  26700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26700
cucagguggc ugggaccaca                                                   20


<210>  26701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26701
cagcucacug cagccucaaa                                                   20


<210>  26702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26702
cugcacuccg gccuggguga                                                   20


<210>  26703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26703
cccaggccgg agugcaguga                                                   20


<210>  26704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26704
cgccuuguca cccaggccgg                                                   20


<210>  26705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26705
cauuuuauga uggauuccug                                                   20


<210>  26706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26706
agauuuaaua cuuuuucuau                                                   20


<210>  26707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26707
caaacauggu aucuuauaga                                                   20


<210>  26708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26708
cauagcaaaa caguguuaaa                                                   20


<210>  26709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26709
gcuuccuuuu cugauucaga                                                   20


<210>  26710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26710
cuaggauaac accucuuuca                                                   20


<210>  26711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26711
ucaccagaaa aagucucuag                                                   20


<210>  26712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26712
cuuuuugcuu uacuuucucu                                                   20


<210>  26713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26713
gcacucaaaa agcuucagaa                                                   20


<210>  26714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26714
gaugauccca aaugaaaaau                                                   20


<210>  26715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26715
aaacuguggc agugauaggg                                                   20


<210>  26716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26716
ucccagcgca acgcugcccc                                                   20


<210>  26717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26717
uuugacccuu ggccauuugu                                                   20


<210>  26718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26718
aaggacaaag gcaggccuca                                                   20


<210>  26719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26719
cugagagcug gacugcugua                                                   20


<210>  26720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26720
agcucucaga gacacuaaca                                                   20


<210>  26721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26721
ccuccaacca cgcacugcgg                                                   20


<210>  26722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26722
cuucuugugu acuugaaaau                                                   20


<210>  26723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26723
gaaccuccau gacuccgagc                                                   20


<210>  26724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26724
uggagguucu gacacuaagg                                                   20


<210>  26725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26725
uguacuggag gcucguggga                                                   20


<210>  26726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26726
cguugugaaa accuuucaac                                                   20


<210>  26727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26727
ucauccugcc gacuauugcc                                                   20


<210>  26728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26728
gcaggaugaa gacguacagu                                                   20


<210>  26729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26729
ucuuuuguuc uuuuccuucu                                                   20


<210>  26730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26730
ggagcugugc ucacgcugua                                                   20


<210>  26731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26731
acauacagcg ugagcacagc                                                   20


<210>  26732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26732
acauccuugc uugucgccgg                                                   20


<210>  26733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26733
accaugcgag ccagcacacg                                                   20


<210>  26734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26734
ccggguagaa augcuucugg                                                   20


<210>  26735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26735
ugacaugguc accgauagaa                                                   20


<210>  26736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26736
agaccauacu uacggaggaa                                                   20


<210>  26737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26737
ccgauagaaa cauggaaaca                                                   20


<210>  26738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26738
gaucugacug uuucuuguau                                                   20


<210>  26739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26739
gaucggacac acgaguaacg                                                   20


<210>  26740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26740
gcccuuacua ggaugaacug                                                   20


<210>  26741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26741
auuagagcag cauggcccag                                                   20


<210>  26742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26742
uccuuguguu aggacaaccc                                                   20


<210>  26743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26743
uuguguuagg acaacccagg                                                   20


<210>  26744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26744
uaacacaagg acgaccugug                                                   20


<210>  26745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26745
ugugaauuua uucccguaca                                                   20


<210>  26746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26746
uccuuuacuc uuuagaaagu                                                   20


<210>  26747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26747
gugacgugag uggaggcagu                                                   20


<210>  26748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26748
cagacgugau ccugccgguc                                                   20


<210>  26749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26749
ugugaugagu gggaaaauag                                                   20


<210>  26750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26750
ucuaauugcu aaacaagagu                                                   20


<210>  26751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26751
cucagauuug ccaacucuug                                                   20


<210>  26752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26752
ugcaugccaa ggauugagua                                                   20


<210>  26753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26753
ucaaagcauu uaaucauuua                                                   20


<210>  26754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26754
uugagaagcc uuugucagaa                                                   20


<210>  26755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26755
gaaaucccua caucuccuau                                                   20


<210>  26756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26756
uggaaauaca cucacauagg                                                   20


<210>  26757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26757
cucucucccu cucacacaca                                                   20


<210>  26758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26758
uuagaguacc uugucuauua                                                   20


<210>  26759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26759
auuaugcuuu ucagucuuua                                                   20


<210>  26760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26760
uuagaguacc uuguugaugg                                                   20


<210>  26761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26761
accuaauugu gcccaauccc                                                   20


<210>  26762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26762
guagggccaa gcucuuuugu                                                   20


<210>  26763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26763
cucucauagc agauggcggg                                                   20


<210>  26764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26764
aaaaguaaua auaguuuauc                                                   20


<210>  26765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26765
agggucaaaa aguaauaaua                                                   20


<210>  26766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26766
ucaguccaga ugagggagau                                                   20


<210>  26767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26767
agaugaggga gauuaaaaga                                                   20


<210>  26768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26768
uuucaaaaua aaaucaccuc                                                   20


<210>  26769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26769
uacugggaua uuugauagug                                                   20


<210>  26770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26770
uagaugaucu guuuuacauu                                                   20


<210>  26771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26771
ugauacaaau gcaggcccua                                                   20


<210>  26772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26772
aaacucugca cacuaggauu                                                   20


<210>  26773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26773
uagucuaaac ucugcacacu                                                   20


<210>  26774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26774
aaaauacaaa uaaaaaugaa                                                   20


<210>  26775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26775
agcagggaau agagccuuug                                                   20


<210>  26776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26776
cuccaccaug caagacucac                                                   20


<210>  26777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26777
ugcauggugg agagacgaaa                                                   20


<210>  26778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26778
cucuccucca gucucuuccc                                                   20


<210>  26779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26779
cuucccaccc gcuggacggg                                                   20


<210>  26780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26780
agcggguggg aagagacugg                                                   20


<210>  26781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26781
cuggaaacag ugaguccgga                                                   20


<210>  26782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26782
ggacaaagua aguguccagc                                                   20


<210>  26783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26783
ggacucacug uuuccaguga                                                   20


<210>  26784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26784
agcgugucug caugggaggc                                                   20


<210>  26785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26785
gcaugggagg cacagggcgc                                                   20


<210>  26786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26786
ccuguggcag auacagagag                                                   20


<210>  26787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26787
acggcaccuc cucugcacuc                                                   20


<210>  26788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26788
cuaaccacag cuucacugag                                                   20


<210>  26789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26789
gagggagcca agcagugcug                                                   20


<210>  26790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26790
cacaucagca cugcuuggcu                                                   20


<210>  26791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26791
gccguggccu gcaggccccu                                                   20


<210>  26792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26792
ggggccugca ggccacggcc                                                   20


<210>  26793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26793
augccguuag ccucccucca                                                   20


<210>  26794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26794
gcaccuccac ugcucauacc                                                   20


<210>  26795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26795
cuaaccauga gguaugagca                                                   20


<210>  26796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26796
aggaaaguag aguaccaagg                                                   20


<210>  26797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26797
ugccuucuua ggcucuauuc                                                   20


<210>  26798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26798
gcuuuacuca ucucucccca                                                   20


<210>  26799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26799
aaaggggaaa accuguggug                                                   20


<210>  26800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26800
ccuugaacgc cgcccaucau                                                   20


<210>  26801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26801
ugggaagaaa aaaauggaua                                                   20


<210>  26802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26802
aaucccagug uuggaccagg                                                   20


<210>  26803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26803
aacacuggga uuugacaaga                                                   20


<210>  26804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26804
gauucugcac ugcuggaagg                                                   20


<210>  26805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26805
caagaaaagc ugaggauucc                                                   20


<210>  26806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26806
caucaucaug ugacccacuu                                                   20


<210>  26807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26807
caugaugaug agacaaaucc                                                   20


<210>  26808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26808
acaagugggu cacaugauga                                                   20


<210>  26809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26809
ccaacaugug uugucaacaa                                                   20


<210>  26810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26810
gggcagggac gggaugucgg                                                   20


<210>  26811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26811
cugcccagac uggagucccc                                                   20


<210>  26812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26812
gagagacucc acucugaaug                                                   20


<210>  26813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26813
cuccgacauc ccgucccugc                                                   20


<210>  26814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26814
uccccacuuc ccggccccau                                                   20


<210>  26815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26815
ggacaugggg guuaugcuga                                                   20


<210>  26816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26816
cgaccccauc ugaaauggag                                                   20


<210>  26817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26817
cgaucagcau aacccccaug                                                   20


<210>  26818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26818
uggccaugga gcuuagauga                                                   20


<210>  26819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26819
agguugcgua uuugccguag                                                   20


<210>  26820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26820
acggcaaaua cgcaaccuug                                                   20


<210>  26821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26821
uaaugcguga cgucaauaac                                                   20


<210>  26822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26822
cgcauuacga cacuguguug                                                   20


<210>  26823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26823
auaacuuguu ucuagugucu                                                   20


<210>  26824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26824
uggaaguuga ucuuuagucg                                                   20


<210>  26825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26825
uaaaagagac ccuuggaugc                                                   20


<210>  26826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26826
cuuuuacgac uaaagaucaa                                                   20


<210>  26827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26827
gagggcaccc ugcgcagagc                                                   20


<210>  26828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26828
cugucccuca cccgugggca                                                   20


<210>  26829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26829
cucacccgug ggcagguccu                                                   20


<210>  26830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26830
ugugagcagu gggggggcca                                                   20


<210>  26831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26831
gagaagaagc ccugcuuggg                                                   20


<210>  26832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26832
uaguaggucu gagaagaagc                                                   20


<210>  26833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26833
ucccaggugc ccacuucccu                                                   20


<210>  26834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26834
cucccggccu cuacaggcau                                                   20


<210>  26835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26835
cuuuucauga acaccugccg                                                   20


<210>  26836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26836
caaaaaaaaa aaaaaagaua                                                   20


<210>  26837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26837
cgcuguuguc ccccaggcug                                                   20


<210>  26838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26838
cccaggcugg agugcaaugg                                                   20


<210>  26839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26839
cuacuaaaaa uacaaaaauu                                                   20


<210>  26840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26840
caaacuccug accucaggug                                                   20


<210>  26841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26841
ggaguuugag accagccugg                                                   20


<210>  26842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26842
gaacuuuuac agcuguucaa                                                   20


<210>  26843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26843
auuuggauua uguuuuagca                                                   20


<210>  26844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26844
uggaugacac uuuagcuuug                                                   20


<210>  26845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26845
uccaagaccu cagugauaca                                                   20


<210>  26846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26846
uaccaaaauu uuuauuucaa                                                   20


<210>  26847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26847
ccucacgggc ugcuucaaaa                                                   20


<210>  26848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26848
aucaugucuu ccagcccgag                                                   20


<210>  26849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26849
uccagcccga gcugccugca                                                   20


<210>  26850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26850
ucggcucaga auuucuuccu                                                   20


<210>  26851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26851
augaauggca aaguggcaaa                                                   20


<210>  26852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26852
uggacauagg gcucuaagcc                                                   20


<210>  26853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26853
augaccaugu caaugaaugg                                                   20


<210>  26854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26854
ggcccagccu uccucaaggg                                                   20


<210>  26855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26855
uguggacgga uguguagaug                                                   20


<210>  26856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26856
acaggacugc acgugguuug                                                   20


<210>  26857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26857
ugagcuuuca ucagauucuc                                                   20


<210>  26858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26858
agcaauucuc ugagaaucug                                                   20


<210>  26859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26859
uucuguuuca ggggaugcug                                                   20


<210>  26860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26860
cugcccacuc uggcccgggc                                                   20


<210>  26861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26861
ccaaacugcc cagucauuug                                                   20


<210>  26862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26862
uuugcaccuu ccuccugaga                                                   20


<210>  26863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26863
uucucuuucu caggaggaag                                                   20


<210>  26864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26864
gccccaugcc cccuccccac                                                   20


<210>  26865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26865
gagaucuugc uuuucaaaua                                                   20


<210>  26866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26866
agucacuuuu ccaucucagc                                                   20


<210>  26867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26867
cuuuuccauc ucagccuggc                                                   20


<210>  26868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26868
ugucaccguc aaguuauugu                                                   20


<210>  26869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26869
ccgucaaguu auuguagcca                                                   20


<210>  26870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26870
aguuauugua gccauccuuc                                                   20


<210>  26871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26871
gccagguccc cuucucaucu                                                   20


<210>  26872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26872
ccuucucauc ugcaccuacc                                                   20


<210>  26873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26873
cuaaaauuag gauccaccua                                                   20


<210>  26874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26874
uaaguuggcc uggacauguc                                                   20


<210>  26875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26875
aggccaacuu aagacauaaa                                                   20


<210>  26876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26876
gccaaggaau acuuacuugg                                                   20


<210>  26877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26877
ggccuguauc cuuaaagggc                                                   20


<210>  26878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26878
uugcugaggg caggcagcac                                                   20


<210>  26879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26879
gcaaagugug uccuugcuga                                                   20


<210>  26880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26880
aaagggcauc agugccauua                                                   20


<210>  26881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26881
uaugguuugu gaucccuguc                                                   20


<210>  26882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26882
uucagguuuc agcuuagugg                                                   20


<210>  26883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26883
gcgugugauc acagcacagg                                                   20


<210>  26884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26884
ucuuauuuga cucucacaac                                                   20


<210>  26885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26885
aauaagauga cgcauauaaa                                                   20


<210>  26886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26886
aaugggagua acagagccua                                                   20


<210>  26887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26887
cugaaauucu cuaagccuug                                                   20


<210>  26888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26888
ucugagcuag gaaguagcca                                                   20


<210>  26889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26889
uagguugaau uugagagcgu                                                   20


<210>  26890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26890
ccucucugcc acaaagcccc                                                   20


<210>  26891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26891
ggacugaaug uaauggagcc                                                   20


<210>  26892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26892
ugacccaccu auuccccaaa                                                   20


<210>  26893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26893
gagcuguccu ucuggaaggg                                                   20


<210>  26894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26894
uucuggaagg gcaagggcac                                                   20


<210>  26895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26895
aggugcccuu gcccuuccag                                                   20


<210>  26896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26896
aaagcacuga ggggcagcgc                                                   20


<210>  26897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26897
cagaaugccc acucguguac                                                   20


<210>  26898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26898
uggcauuuga uccaugagca                                                   20


<210>  26899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26899
ggaucuccag gcagggcugg                                                   20


<210>  26900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26900
agcccugccu ggagauccag                                                   20


<210>  26901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26901
ccuccacaga guuugugacc                                                   20


<210>  26902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26902
caaacucugu ggaggagacc                                                   20


<210>  26903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26903
ccguccauga acgguggguu                                                   20


<210>  26904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26904
augaacggug gguuccuauc                                                   20


<210>  26905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26905
gcuucaccau guuuuuauuu                                                   20


<210>  26906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26906
acacuggaau uuaacuggaa                                                   20


<210>  26907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26907
uuuuauuuag auuuugaagu                                                   20


<210>  26908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26908
cugugaucuu uggucuuagc                                                   20


<210>  26909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26909
uagcuguuuu auguauuuag                                                   20


<210>  26910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26910
uauaugauca uaagauuaau                                                   20


<210>  26911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26911
gaguuaaaau guuuguuuuu                                                   20


<210>  26912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26912
uuagccacaa uuuuuaaaaa                                                   20


<210>  26913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26913
aauuuuuuaa aaauuguggc                                                   20


<210>  26914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26914
uaguuuacau guuagagggc                                                   20


<210>  26915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26915
ggcuuuuaag uaguaauccc                                                   20


<210>  26916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26916
cauaauaacc ucagggugag                                                   20


<210>  26917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26917
ccuguuggcc aucucucacc                                                   20


<210>  26918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26918
agggacuuag aaaucugaau                                                   20


<210>  26919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26919
cucgacuguc uccuguuggc                                                   20


<210>  26920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26920
gaagauuuga acuucagauu                                                   20


<210>  26921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26921
aguauugucu guuugucuaa                                                   20


<210>  26922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26922
guuugucuaa aauugguucu                                                   20


<210>  26923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26923
aaaauugguu cuaaggaauc                                                   20


<210>  26924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26924
gucuaucccu uucaacuuuu                                                   20


<210>  26925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26925
aucccuuuca acuuuuguga                                                   20


<210>  26926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26926
agaaagaagg acaaauaccc                                                   20


<210>  26927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26927
uucuuucugg acuaagaagc                                                   20


<210>  26928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26928
caggacccau uuuuuucuua                                                   20


<210>  26929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26929
ugagacuuac ucuguguguu                                                   20


<210>  26930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26930
uggaggaaca acauguaaga                                                   20


<210>  26931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26931
cugugaauga uuuuuaaguc                                                   20


<210>  26932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26932
acacucaccg cggugcacgu                                                   20


<210>  26933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26933
ugcugcuccu cccuagcugu                                                   20


<210>  26934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26934
gggaggcugu aguccauugc                                                   20


<210>  26935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26935
auugcuuugc cagcucuuuu                                                   20


<210>  26936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26936
cugacccuac agaccagcug                                                   20


<210>  26937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26937
gagacagccg cauguguacg                                                   20


<210>  26938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26938
guagggucag agacagccgc                                                   20


<210>  26939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26939
ucuuuguguu cucagaaauu                                                   20


<210>  26940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26940
gcaagcaaca accuuuuguu                                                   20


<210>  26941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26941
gguucagcca ucuguuuugg                                                   20


<210>  26942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26942
auaacuggcu uaaaucacug                                                   20


<210>  26943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26943
aagucuauaa cuggcuuaaa                                                   20


<210>  26944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26944
uuuguucuug ccagggcccc                                                   20


<210>  26945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26945
gguggggaau ggccccuguu                                                   20


<210>  26946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26946
cacagaggug ggggugccuc                                                   20


<210>  26947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26947
acacauuuua cacagcacgc                                                   20


<210>  26948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26948
uuagucuucu gcauaguacu                                                   20


<210>  26949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26949
ucugcauagu acuuuucucu                                                   20


<210>  26950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26950
uucucuaauu acaaaaccuu                                                   20


<210>  26951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26951
uuggcugugc auuaaaaugc                                                   20


<210>  26952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26952
uucaggcuuc aguuugugau                                                   20


<210>  26953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26953
uccguuccag gugcuuuaca                                                   20


<210>  26954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26954
uguuaugaau acucaacaaa                                                   20


<210>  26955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26955
caacuguuuu aaagcaaugg                                                   20


<210>  26956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26956
uaucgaggug auuaaaaaaa                                                   20


<210>  26957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26957
uccaauaaau auuaauaggc                                                   20


<210>  26958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26958
ggagaucgag accaucccag                                                   20


<210>  26959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26959
cgaucuccug accucgugau                                                   20


<210>  26960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26960
cuacuaaaaa uacaaaaaau                                                   20


<210>  26961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26961
cagcuacuug ggaggcugag                                                   20


<210>  26962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26962
cccaggcugg agugcagugg                                                   20


<210>  26963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26963
ugcucugucg cccaggcugg                                                   20


<210>  26964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26964
caaaaaaaaa aaaaaauauu                                                   20


<210>  26965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26965
aaugagaagu ccuucucuau                                                   20


<210>  26966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26966
uucucuaucc uaggaaguug                                                   20


<210>  26967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26967
agaauaucau accuacuaaa                                                   20


<210>  26968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26968
ugagucuaga auaucauacc                                                   20


<210>  26969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26969
acagcgucug ccuugggagu                                                   20


<210>  26970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26970
gccuugggag uuuccaugcc                                                   20


<210>  26971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26971
gagugcuuga ggggcuuggg                                                   20


<210>  26972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26972
uccuugcuuc acuggcuuuc                                                   20


<210>  26973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26973
cucagcuagu aucaaagggc                                                   20


<210>  26974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26974
gucccucagc uaguaucaaa                                                   20


<210>  26975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26975
ugggagacca gagaaagacg                                                   20


<210>  26976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26976
cccaggaccu gugucugucc                                                   20


<210>  26977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26977
uucucugguc ucccaggacc                                                   20


<210>  26978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26978
uaaaggaagu cugaggcuga                                                   20


<210>  26979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26979
gaggcugagg agccacagga                                                   20


<210>  26980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26980
caggcugcug cuggccuuau                                                   20


<210>  26981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26981
ugaaccugag cucuggccuu                                                   20


<210>  26982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26982
aaguggauuc cacaguuaca                                                   20


<210>  26983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26983
ugcuuucuac acugggcaua                                                   20


<210>  26984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26984
ucucuuaacc guugcuuguu                                                   20


<210>  26985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26985
cugcagucgg uguuggccuu                                                   20


<210>  26986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26986
guguuggccu ugggucauaa                                                   20


<210>  26987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26987
uaaaaggaau agcggcgugc                                                   20


<210>  26988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26988
acagcuacac acgugugccc                                                   20


<210>  26989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26989
gcucguuccu ugcagaagac                                                   20


<210>  26990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26990
ucugcaagga acgagcagac                                                   20


<210>  26991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26991
cgcccucuca cgugugccca                                                   20


<210>  26992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26992
cuaguagaaa uacuggguuu                                                   20


<210>  26993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26993
aacacuaauc ucuuagggau                                                   20


<210>  26994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26994
aguugcucua gaaucagguc                                                   20


<210>  26995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26995
gcuauuaagc aaaguggucu                                                   20


<210>  26996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26996
ucagaauugg uuuaaaguag                                                   20


<210>  26997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26997
ggauuucgag accagccugg                                                   20


<210>  26998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26998
cgaaauccug accucaagug                                                   20


<210>  26999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  26999
ccugaguagc ugggauuaca                                                   20


<210>  27000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27000
cagucuccug aguagcuggg                                                   20


<210>  27001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27001
ugcucuguug cccaggcuag                                                   20


<210>  27002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27002
caaaaaaaaa aaagguaggu                                                   20


<210>  27003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27003
cccuccauca acccucacuc                                                   20


<210>  27004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27004
gucccccucc aucaacccuc                                                   20


<210>  27005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27005
gccuuucuuu ccugccugag                                                   20


<210>  27006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27006
gggagaaugg agccaggucc                                                   20


<210>  27007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27007
cagggaagag gcuuguggcu                                                   20


<210>  27008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27008
agggaggcuu gcuccaagga                                                   20


<210>  27009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27009
uuggagcaag ccucccuaga                                                   20


<210>  27010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27010
cuguggguuc auuagcaucu                                                   20


<210>  27011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27011
cauaaccaga ugcuaaugaa                                                   20


<210>  27012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27012
ccacgagccc cuccaaagga                                                   20


<210>  27013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27013
ugaggucaug ccguccagag                                                   20


<210>  27014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27014
ugccguccag agcacaccug                                                   20


<210>  27015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27015
agagcacacc ugaggauagg                                                   20


<210>  27016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27016
uggccuaucc ucaggugugc                                                   20


<210>  27017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27017
ucuggaaggc agcuguaaca                                                   20


<210>  27018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27018
cucccugggu ggguaccaga                                                   20


<210>  27019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27019
uuaucauaga gcccccucug                                                   20


<210>  27020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27020
uuugucaccu cacugaaggc                                                   20


<210>  27021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27021
ccucacugaa ggcauguaag                                                   20


<210>  27022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27022
ggccagcuca gcuuacaugc                                                   20


<210>  27023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27023
gagcaccuca cgcacagaga                                                   20


<210>  27024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27024
aguucucugu gcgugaggug                                                   20


<210>  27025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27025
cuaacuccug ccugcuucuc                                                   20


<210>  27026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27026
ucauccugag gcugcuggca                                                   20


<210>  27027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27027
caggaagcag uuggagcugu                                                   20


<210>  27028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27028
cagagcuggc accuucuccc                                                   20


<210>  27029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27029
ggcuuccugc uuccucacag                                                   20


<210>  27030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27030
guccugacuc aacucggaug                                                   20


<210>  27031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27031
ugacucaacu cggaugaugu                                                   20


<210>  27032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27032
ggacagacau acugugagga                                                   20


<210>  27033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27033
cuuccuuuuc aucuucucag                                                   20


<210>  27034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27034
cccaaaccgg gaggggauuu                                                   20


<210>  27035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27035
uuaaggaguu caucuaccgc                                                   20


<210>  27036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27036
ccauugucgg acaucuaccg                                                   20


<210>  27037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27037
gacaucuacc gggaggaaau                                                   20


<210>  27038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27038
gacaauggug accugaagga                                                   20


<210>  27039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27039
aaugagaaga ucccaguacu                                                   20


<210>  27040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27040
ggaaagguuc auguguagug                                                   20


<210>  27041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27041
acuacacaug aaccuuuccu                                                   20


<210>  27042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27042
cacguugucc acuacacaug                                                   20


<210>  27043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27043
cagaauguuu ucuuguguuc                                                   20


<210>  27044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27044
gauccuguug ugucucagug                                                   20


<210>  27045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27045
caguggucca uuuucucaua                                                   20


<210>  27046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27046
auuuucucau augggaacaa                                                   20


<210>  27047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27047
gcuuguuccc auaugagaaa                                                   20


<210>  27048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27048
gguuucuugg cacucgccuu                                                   20


<210>  27049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27049
gagccccaag ccugcuuucu                                                   20


<210>  27050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27050
uggucugcuu ccagcccucc                                                   20


<210>  27051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27051
gcuuccagcc cuccuaccug                                                   20


<210>  27052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27052
gucuaaccuc uagagacccu                                                   20


<210>  27053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27053
aaccucuaga gacccucagu                                                   20


<210>  27054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27054
cuagagguua gacggacuug                                                   20


<210>  27055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27055
uauguaaaau gggggucgug                                                   20


<210>  27056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27056
ugucuauuuc auagaauugu                                                   20


<210>  27057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27057
auuucauaga auuguugcag                                                   20


<210>  27058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27058
aaaugaauaa gucaccacuu                                                   20


<210>  27059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27059
ccacuuuugc cccuauuuga                                                   20


<210>  27060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27060
caccacaaga ucacaccucu                                                   20


<210>  27061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27061
guucucagug acugugcccu                                                   20


<210>  27062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27062
cugagaacug acugauuaca                                                   20


<210>  27063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27063
uguccuagaa agucuggcag                                                   20


<210>  27064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27064
uagaaagucu ggcaggggca                                                   20


<210>  27065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27065
ggcaggggca cccugacucc                                                   20


<210>  27066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27066
gggugccccu gccagacuuu                                                   20


<210>  27067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27067
aguccucucc ccagucccuc                                                   20


<210>  27068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27068
ucuccccagu cccucgggcu                                                   20


<210>  27069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27069
cucgggcuuc ugcagauuug                                                   20


<210>  27070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27070
ccugccacaa ccuucuggga                                                   20


<210>  27071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27071
aaagagagcc cugagcaggu                                                   20


<210>  27072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27072
gaugggcagu ucaagagcaa                                                   20


<210>  27073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27073
cgcacguccg augggcaguu                                                   20


<210>  27074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27074
ugggucacgc acguccgaug                                                   20


<210>  27075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27075
uugccuuguc ugugcucauu                                                   20


<210>  27076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27076
gugcucauuu ucuuuguuca                                                   20


<210>  27077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27077
guaucugugu cugaaucagu                                                   20


<210>  27078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27078
gaaucagucc ugcacgcucu                                                   20


<210>  27079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27079
ugcacgcucu ccuucucucu                                                   20


<210>  27080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27080
cuuguucuuu cuuuaccccg                                                   20


<210>  27081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27081
ccgugauaaa cgggguaaag                                                   20


<210>  27082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27082
auugcucuag uucuccuguc                                                   20


<210>  27083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27083
uaagcacccc aucccgucuc                                                   20


<210>  27084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27084
cucuggccuu accacaagug                                                   20


<210>  27085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27085
gaggcagcca cgccacuugu                                                   20


<210>  27086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27086
ccaucaugau gucugaggca                                                   20


<210>  27087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27087
gaaacaacug uucguuagau                                                   20


<210>  27088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27088
gucggaugua uuuucacuga                                                   20


<210>  27089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27089
gauguauuuu cacugaaucc                                                   20


<210>  27090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27090
agaagaauag auuaaaaaga                                                   20


<210>  27091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27091
gaggaaccau uacuuugacu                                                   20


<210>  27092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27092
aaguaauggu uccucugacc                                                   20


<210>  27093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27093
gcuuagagug ggugaaaucu                                                   20


<210>  27094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27094
cagggcugga cuccagggaa                                                   20


<210>  27095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27095
agcccugaga cugugcagcu                                                   20


<210>  27096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27096
cugcccuguc ccugugucug                                                   20


<210>  27097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27097
cugugucugc uccacugggg                                                   20


<210>  27098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27098
gcuccacugg ggguugacca                                                   20


<210>  27099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27099
acccccagug gagcagacac                                                   20


<210>  27100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27100
gcccuggcag ccuggucaac                                                   20


<210>  27101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27101
cggacagugc agccgauguc                                                   20


<210>  27102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27102
gagacacaug agaggcaggu                                                   20


<210>  27103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27103
auacuucggu uuccucaaug                                                   20


<210>  27104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27104
cuuaaaccuc acacaguucu                                                   20


<210>  27105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27105
gcguagcugu cagcucuccg                                                   20


<210>  27106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27106
gcucuccguu acaggcuuga                                                   20


<210>  27107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27107
acccuucuca agccuguaac                                                   20


<210>  27108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27108
agccuagaaa uauaaauguu                                                   20


<210>  27109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27109
uacucaguuu gaagaaacuu                                                   20


<210>  27110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27110
uggugacgca gccccucgug                                                   20


<210>  27111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27111
ccaggacacc aaggagggug                                                   20


<210>  27112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27112
ugacugauau uccagagcag                                                   20


<210>  27113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27113
agacaccauu cagcuacucu                                                   20


<210>  27114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27114
cugcucugga auaucaguca                                                   20


<210>  27115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27115
gggggcugcg auuaccaaug                                                   20


<210>  27116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27116
ugcagagauu uuaucaggcu                                                   20


<210>  27117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27117
uuucugugag uucaaaccac                                                   20


<210>  27118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27118
acccuccaaa cugucauuuc                                                   20


<210>  27119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27119
caagucauca agauugucuu                                                   20


<210>  27120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27120
ucaagauugu cuuuaaauuc                                                   20


<210>  27121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27121
uuaaauucau gcauagaagc                                                   20


<210>  27122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27122
uaagcaaggc cuguaaaaug                                                   20


<210>  27123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27123
uugauuugaa aaaugggcuu                                                   20


<210>  27124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27124
ggcugagcuc acggggcaca                                                   20


<210>  27125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27125
ucccugccuc aaugggagga                                                   20


<210>  27126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27126
ugcugcucuu guugacaugu                                                   20


<210>  27127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27127
acaagagcag caagacaccc                                                   20


<210>  27128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27128
uccuggaagg agagcccaca                                                   20


<210>  27129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27129
ucucuguguc uuccuggaag                                                   20


<210>  27130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27130
uggccgugca ggccaucacc                                                   20


<210>  27131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27131
uugcacugag caccagugag                                                   20


<210>  27132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27132
agagcuuuca gaggcuuguu                                                   20


<210>  27133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27133
cugggacaua gcaggugcug                                                   20


<210>  27134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27134
cagagacacg ugggaacuca                                                   20


<210>  27135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27135
ccagcaccug cuauguccca                                                   20


<210>  27136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27136
agcagcuuca accaggccgu                                                   20


<210>  27137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27137
guguggccug ugcaggagau                                                   20


<210>  27138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27138
gcaucuccug cacaggccac                                                   20


<210>  27139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27139
gugagaagcu ggaaacguga                                                   20


<210>  27140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27140
cguuuccagc uucucacuga                                                   20


<210>  27141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27141
guuccuguca cguuuccagc                                                   20


<210>  27142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27142
uccccuaaau gcucaauaac                                                   20


<210>  27143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27143
gugagcccuu aagugggugu                                                   20


<210>  27144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27144
cuucucuguc uccggcuacu                                                   20


<210>  27145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27145
ccggcuacua cagguaccug                                                   20


<210>  27146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27146
ucucucauuc uagcccaagu                                                   20


<210>  27147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27147
ucccgcauca cugguguggu                                                   20


<210>  27148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27148
gaguuggagg cuguggugcu                                                   20


<210>  27149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27149
uagucaggcc cagggaggaa                                                   20


<210>  27150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27150
ggcccaggga ggaaguaaaa                                                   20


<210>  27151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27151
agaaaugaga agcgaaagaa                                                   20


<210>  27152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27152
uacagcccgu gagaauucuu                                                   20


<210>  27153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27153
cugcccacuc ucccaccaag                                                   20


<210>  27154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27154
ccugguuuaa aagaagagag                                                   20


<210>  27155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27155
acauagaacu uucugcaauu                                                   20


<210>  27156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27156
augagacuca aauguuuauu                                                   20


<210>  27157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27157
cauagacacu gcguauaaca                                                   20


<210>  27158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27158
ggaggaccca ggagcaauga                                                   20


<210>  27159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27159
uccugacuua ugagcuccuu                                                   20


<210>  27160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27160
uugcuccugg guccuccuga                                                   20


<210>  27161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27161
uagaaggcag aaaagagggg                                                   20


<210>  27162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27162
ggcagagggu uagcugggga                                                   20


<210>  27163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27163
ccagcuaacc cucugccaga                                                   20


<210>  27164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27164
uucugcuggg caucccccca                                                   20


<210>  27165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27165
gccugggcac cgaggugggg                                                   20


<210>  27166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27166
cccagagagc uugccugccu                                                   20


<210>  27167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27167
aggcaggcaa gcucucuggg                                                   20


<210>  27168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27168
gcucgccugc aacugcugac                                                   20


<210>  27169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27169
gcaguugcag gcgagccgac                                                   20


<210>  27170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27170
ccccucagcu cccaccucug                                                   20


<210>  27171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27171
cuugucaccc cucagcuccc                                                   20


<210>  27172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27172
uauuugucau agagaaaaag                                                   20


<210>  27173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27173
uagagaaaaa gugacagagu                                                   20


<210>  27174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27174
cuuuuucucu augacaaaua                                                   20


<210>  27175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27175
agcuugccca cuggcccugc                                                   20


<210>  27176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27176
cuuuauaacc aguuaagcug                                                   20


<210>  27177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27177
uggggauuug ucacuuuaua                                                   20


<210>  27178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27178
gggcaggagc ugggcuggua                                                   20


<210>  27179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27179
ugaucugcac aggggggcag                                                   20


<210>  27180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27180
gucucgcgcc cccgccgccu                                                   20


<210>  27181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27181
cgcgcccccg ccgccuggcc                                                   20


<210>  27182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27182
guuucugucc ucagacuuug                                                   20


<210>  27183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27183
ucagacuuug gcgcuugaca                                                   20


<210>  27184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27184
gaggacagaa acggacagag                                                   20


<210>  27185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27185
agcgccaaag ucugaggaca                                                   20


<210>  27186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27186
cgcaagcaga ggaagcauua                                                   20


<210>  27187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27187
cuuaacuacu uucuggaaua                                                   20


<210>  27188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27188
cuuacacaca ucucuaucgc                                                   20


<210>  27189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27189
cgcccucuca cugucucuua                                                   20


<210>  27190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27190
aagucacgcc cucucacugu                                                   20


<210>  27191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27191
uugcuuaagu ccaagucacg                                                   20


<210>  27192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27192
cacgguccuu gcuuaagucc                                                   20


<210>  27193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27193
ucaccccccu uuuugugucu                                                   20


<210>  27194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27194
gcugaaaugc ucaggaggaa                                                   20


<210>  27195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27195
acuuccuccu gagcauuuca                                                   20


<210>  27196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27196
cuggggccag cucuuggggg                                                   20


<210>  27197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27197
cugucccugu ggccaguucu                                                   20


<210>  27198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27198
cuguggccag uucugggugg                                                   20


<210>  27199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27199
gccugcacac ggggcuccca                                                   20


<210>  27200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27200
cauuggucug ugcuucuguu                                                   20


<210>  27201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27201
gugcuucugu uuccuccuca                                                   20


<210>  27202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27202
ggguguggug gcuaacaccu                                                   20


<210>  27203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27203
guugcccagg cuggagugca                                                   20


<210>  27204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27204
cuuaaaaaaa aauguaaaca                                                   20


<210>  27205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27205
gccagcacag ccgggccccg                                                   20


<210>  27206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27206
uucgcucacc ggguuccuga                                                   20


<210>  27207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27207
ugcacaacug cuuucacuaa                                                   20


<210>  27208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27208
gaauauggug uuuagaaaca                                                   20


<210>  27209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27209
caagccuguu ucuguucccu                                                   20


<210>  27210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27210
uguuuugugc cugccgguuu                                                   20


<210>  27211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27211
cugaaaccgg caggcacaaa                                                   20


<210>  27212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27212
aguagcuccc ugcuuccugu                                                   20


<210>  27213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27213
agaaaaauac aggcuggucc                                                   20


<210>  27214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27214
cacucuucug uccuuucacc                                                   20


<210>  27215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27215
uuucaccuuu gacagauguu                                                   20


<210>  27216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27216
aaggugaaag gacagaagag                                                   20


<210>  27217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27217
uuuucacuua ucuuggggug                                                   20


<210>  27218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27218
ugggcccagg gacacugguc                                                   20


<210>  27219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27219
cugggcccag gacaaggcca                                                   20


<210>  27220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27220
gugcccgagg uauucccuau                                                   20


<210>  27221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27221
agcguccgca aaccaacugu                                                   20


<210>  27222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27222
gcaaaccaac ugucauggga                                                   20


<210>  27223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27223
ugggaucaua cuggggcuga                                                   20


<210>  27224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27224
caccccugcc cugucugggg                                                   20


<210>  27225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27225
ggggcugaag uacagugcca                                                   20


<210>  27226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27226
ggggcugaag gacagugcca                                                   20


<210>  27227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27227
uucagcccca gacagggcag                                                   20


<210>  27228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27228
ggggcugaag uacagugcca                                                   20


<210>  27229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27229
ggggcugaag gacagugcca                                                   20


<210>  27230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27230
uucagcccca gacagggcag                                                   20


<210>  27231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27231
ggggcugaag gacagugcca                                                   20


<210>  27232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27232
uucagcccca gacagggaag                                                   20


<210>  27233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27233
ggggcugaag gacagugcca                                                   20


<210>  27234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27234
uucagcccca gacagggcag                                                   20


<210>  27235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27235
ggggcugaag gacagugcca                                                   20


<210>  27236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27236
uucagcccca gacagggcag                                                   20


<210>  27237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27237
ggggcugaag gacagugcca                                                   20


<210>  27238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27238
uucagcccca gacagggcag                                                   20


<210>  27239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27239
ggggcugaag gacagugcca                                                   20


<210>  27240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27240
uucagcccca gacagggcag                                                   20


<210>  27241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27241
ggggcugaag gacagugcca                                                   20


<210>  27242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27242
uucagcccca gacagggcag                                                   20


<210>  27243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27243
ggggcugaag gacagugcca                                                   20


<210>  27244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27244
uucagcccca gacagggcag                                                   20


<210>  27245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27245
ggggcugaag gacagugcca                                                   20


<210>  27246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27246
uucagcccca gacagggcag                                                   20


<210>  27247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27247
ggggcugaag gacagugcca                                                   20


<210>  27248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27248
uucagcccca gacagggcag                                                   20


<210>  27249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27249
ggggcugaag gacagugcca                                                   20


<210>  27250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27250
uucagcccca gacagggcag                                                   20


<210>  27251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27251
ggggcugaag gacagugcca                                                   20


<210>  27252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27252
uucagcccca gacagggcag                                                   20


<210>  27253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27253
ggggcugaag gacagugcca                                                   20


<210>  27254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27254
uucagcccca gacagggcag                                                   20


<210>  27255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27255
ggggcugaag gacagugcca                                                   20


<210>  27256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27256
uucagcccca gacagggcag                                                   20


<210>  27257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27257
ggggcugaag gacagugcca                                                   20


<210>  27258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27258
uucagcccca gacagggcag                                                   20


<210>  27259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27259
gggauguuua gccccuagau                                                   20


<210>  27260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27260
aguggcaucu aggggcuaaa                                                   20


<210>  27261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27261
gggcgagggg agugcagggg                                                   20


<210>  27262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27262
guaugaacag cucucaggcc                                                   20


<210>  27263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27263
caggggggaa auggcccuug                                                   20


<210>  27264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27264
uccuuucugc cugguucucg                                                   20


<210>  27265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27265
aggugugcug acugcguggu                                                   20


<210>  27266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27266
gcacaccucg acuguccucc                                                   20


<210>  27267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27267
caaaggcgcg agggagcucu                                                   20


<210>  27268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27268
uugcgguaaa cccaaggcca                                                   20


<210>  27269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27269
cccgcacugg cagucauugc                                                   20


<210>  27270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27270
ccaaaacacg gaaccaauac                                                   20


<210>  27271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27271
cuuaggagug aaagcauccc                                                   20


<210>  27272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27272
cccuccucag cugcuccugg                                                   20


<210>  27273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27273
accccaggag cagcugagga                                                   20


<210>  27274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27274
agccccugcc ccacccucuc                                                   20


<210>  27275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27275
gaacgacccu ugcuaagggg                                                   20


<210>  27276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27276
uucagacacc ccagguuacg                                                   20


<210>  27277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27277
gccccuuagc aagggucguu                                                   20


<210>  27278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27278
aacagucugc cccuuagcaa                                                   20


<210>  27279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27279
caguggccac acccacccac                                                   20


<210>  27280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27280
auacacuccg uguggcuggg                                                   20


<210>  27281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27281
cauuccuccu cccucagggg                                                   20


<210>  27282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27282
gccuccuccu ccucuuccuc                                                   20


<210>  27283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27283
ccacccacgu cuccagucaa                                                   20


<210>  27284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27284
ccagucaacu ccagguuuuc                                                   20


<210>  27285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27285
acuccagguu uuccaauggc                                                   20


<210>  27286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27286
uuugauuugu uugaggugcu                                                   20


<210>  27287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27287
acuccagccc gguguuuccu                                                   20


<210>  27288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27288
agcucagcca ggaggacccc                                                   20


<210>  27289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27289
uccuggcuga gcuggacggc                                                   20


<210>  27290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27290
gauccguaag ugagccuucc                                                   20


<210>  27291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27291
auggugcgug uggccugugu                                                   20


<210>  27292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27292
ggugcaugca cauguggcau                                                   20


<210>  27293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27293
gugugggugc gugguacacg                                                   20


<210>  27294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27294
cgcacaguaa ugucucuugg                                                   20


<210>  27295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27295
cuugggugua agaacacgac                                                   20


<210>  27296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27296
uguucuuaca cccaagagac                                                   20


<210>  27297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27297
cagacuuguu caccgagcgc                                                   20


<210>  27298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27298
gagaccacua gaagcuggag                                                   20


<210>  27299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27299
cauacaucag cucaaacugg                                                   20


<210>  27300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27300
gcgucacaua caucagcuca                                                   20


<210>  27301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27301
ucugaagggu gcacccuucg                                                   20


<210>  27302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27302
uugggauggu aagugacagg                                                   20


<210>  27303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27303
cuuaccaucc caaggacggc                                                   20


<210>  27304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27304
caaggcagau gggcccccgu                                                   20


<210>  27305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27305
acucuuggaa ggaggcagcc                                                   20


<210>  27306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27306
gguucggguc aacucuugga                                                   20


<210>  27307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27307
cugaaccccc uccaucugag                                                   20


<210>  27308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27308
gugccauuca caggucacug                                                   20


<210>  27309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27309
cugugaugug gguuguggcg                                                   20


<210>  27310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27310
cguaucccug ggcuuaugac                                                   20


<210>  27311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27311
uaagcccagg gauacgggac                                                   20


<210>  27312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27312
ggccucaggg cagagcaugg                                                   20


<210>  27313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27313
agccaggaag cucggggggc                                                   20


<210>  27314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27314
cagugacccu guguuucuag                                                   20


<210>  27315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27315
cugugacaaa acggccccca                                                   20


<210>  27316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27316
caaaucuggg ugcuauaguc                                                   20


<210>  27317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27317
cuuuuuagcg uggugguugu                                                   20


<210>  27318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27318
uagucuuuuu uggcugcuac                                                   20


<210>  27319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27319
uuuuuggcug cuaccacaag                                                   20


<210>  27320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27320
aagguaacuu gugguagcag                                                   20


<210>  27321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27321
aggugccagc agauuuggug                                                   20


<210>  27322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27322
ucacggugga aggagugaac                                                   20


<210>  27323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27323
ugaugggaga gcccuugugg                                                   20


<210>  27324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27324
guguaggagu uucaggaggg                                                   20


<210>  27325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27325
gaauguuucu aucccuccug                                                   20


<210>  27326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27326
aguguucauc cucuugaguu                                                   20


<210>  27327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27327
cgacaucugg cgaagcauau                                                   20


<210>  27328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27328
ggacccacgg gcaaugauuu                                                   20


<210>  27329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27329
gagcuggcac cucugguucc                                                   20


<210>  27330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27330
uguggcauua ccuaguaauc                                                   20


<210>  27331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27331
ggggcccuug gugagaaugg                                                   20


<210>  27332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27332
agagcacggg cuaggcaggc                                                   20


<210>  27333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27333
ggaacgacaa ugcugucaug                                                   20


<210>  27334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27334
uuccugacac acaggagccc                                                   20


<210>  27335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27335
ugacggugaa ugauuuuuuu                                                   20


<210>  27336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27336
ugacagcauu gucguuccug                                                   20


<210>  27337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27337
ggugggggug cgggaggaag                                                   20


<210>  27338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27338
cccuuggccu ugucaggugg                                                   20


<210>  27339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27339
gagguuagcu ggcuugucug                                                   20


<210>  27340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27340
gggucacaca aaaugcagca                                                   20


<210>  27341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27341
cacaaaaugc agcagagguu                                                   20


<210>  27342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27342
gugaccugga gccugacucc                                                   20


<210>  27343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27343
cggacaugug cucaccucaa                                                   20


<210>  27344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27344
ggcuccaggu cacggacaug                                                   20


<210>  27345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27345
ugacugcucu ugccuagacu                                                   20


<210>  27346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27346
agacucgcag agagggaguc                                                   20


<210>  27347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27347
aggcaagagc agucaagacu                                                   20


<210>  27348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27348
uccccgagcc caaacgccag                                                   20


<210>  27349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27349
ucuucccuug uggguguccu                                                   20


<210>  27350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27350
uucagccugg ugccaugcug                                                   20


<210>  27351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27351
ccagcauggc accaggcuga                                                   20


<210>  27352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27352
agggagugga aacaauugag                                                   20


<210>  27353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27353
aagcggcucu uggaaggggu                                                   20


<210>  27354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27354
uucuccuuug ugggaaguuu                                                   20


<210>  27355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27355
uggacacuca cucccagcuc                                                   20


<210>  27356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27356
augaccaucc ugccuuagga                                                   20


<210>  27357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27357
ugcuugguac ccacguaucc                                                   20


<210>  27358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27358
uuuugaggua uuugcccacc                                                   20


<210>  27359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27359
ugaugugggg cuuucagaag                                                   20


<210>  27360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27360
cacuucugaa agccccacau                                                   20


<210>  27361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27361
uuagggaggg gccguguggc                                                   20


<210>  27362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27362
cuuccuucuu gggcccccac                                                   20


<210>  27363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27363
uuguuccugg gauggcuggg                                                   20


<210>  27364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27364
uccggccauu uccccugcgg                                                   20


<210>  27365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27365
ggccauuucc ccugcggaga                                                   20


<210>  27366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27366
ccauagucuu gggcugaagg                                                   20


<210>  27367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27367
ugggcugaag gagggugaca                                                   20


<210>  27368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27368
cccuccuuca gcccaagacu                                                   20


<210>  27369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27369
gcaaggaaug ucacccuccu                                                   20


<210>  27370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27370
ccucacuguu aaagagcaga                                                   20


<210>  27371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27371
auauuuaacc cugcuagguu                                                   20


<210>  27372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27372
acuucaacca aaauggccuc                                                   20


<210>  27373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27373
uggggauccc ugauaguggu                                                   20


<210>  27374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27374
uucuagaaaa gccuggggua                                                   20


<210>  27375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27375
cgaggacacc aggcuugagc                                                   20


<210>  27376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27376
ucgggacauc gccccauggg                                                   20


<210>  27377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27377
ugcaggacgc acuuaacucc                                                   20


<210>  27378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27378
ugcacgaccc cgcugggaga                                                   20


<210>  27379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27379
cggcucacug ugcggggagu                                                   20


<210>  27380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27380
ucgccaggaa agcacacuag                                                   20


<210>  27381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27381
ccaggaaagc acacuagaga                                                   20


<210>  27382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27382
cuagugugcu uuccuggcga                                                   20


<210>  27383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27383
gggcacgagg caggcagagg                                                   20


<210>  27384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27384
agagucuggg cacgaggcag                                                   20


<210>  27385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27385
caacaccagc caggggccag                                                   20


<210>  27386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27386
ccggccugcu guguagucuc                                                   20


<210>  27387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27387
cuucugcaca caagcgugag                                                   20


<210>  27388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27388
caguggcucc uccccacagc                                                   20


<210>  27389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27389
gugugugccu aggacaaggc                                                   20


<210>  27390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27390
uaggcacaca cagacaaaag                                                   20


<210>  27391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27391
gccgccugcu ggagagcacg                                                   20


<210>  27392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27392
ucuaugugcu ggagugcgac                                                   20


<210>  27393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27393
cacuccagca cauagaggac                                                   20


<210>  27394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27394
agcaggucgc acuccagcac                                                   20


<210>  27395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27395
uccagcaggu cgcacuccag                                                   20


<210>  27396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27396
ucagcgacua ucuccucucc                                                   20


<210>  27397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27397
cugaugaccg ggaugagcug                                                   20


<210>  27398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27398
cagaaugagc ugugaaggaa                                                   20


<210>  27399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27399
gugagacgca agagcacagg                                                   20


<210>  27400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27400
cacugaccuc agccauggca                                                   20


<210>  27401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27401
uagaggcuuc cucgggcacc                                                   20


<210>  27402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27402
cauguggcgc uuagcacacu                                                   20


<210>  27403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27403
ggaaugggca cgugggagag                                                   20


<210>  27404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27404
gaaucacagu ggaaacaaga                                                   20


<210>  27405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27405
agcagcuuua agauaaggug                                                   20


<210>  27406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27406
uugacaaagc acggcuggug                                                   20


<210>  27407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27407
aggacacgug uguacagaac                                                   20


<210>  27408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27408
agcucuucac agcgaugucu                                                   20


<210>  27409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27409
uacaagcgca gagggcucug                                                   20


<210>  27410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27410
cagagcccuc ugcgcuugua                                                   20


<210>  27411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27411
caccgccacu cuuccaaagu                                                   20


<210>  27412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27412
cagaggcuuu agcagagaug                                                   20


<210>  27413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27413
uaggcuucug cacacgggag                                                   20


<210>  27414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27414
uuagagggag gguggaauuu                                                   20


<210>  27415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27415
gggaggaaug gccagugauc                                                   20


<210>  27416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27416
aaggggauca cuggccauuc                                                   20


<210>  27417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27417
aaguugagug gaagaccugg                                                   20


<210>  27418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27418
uccacucaac uuugaccuag                                                   20


<210>  27419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27419
cccuccaggu cuuccacuca                                                   20


<210>  27420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27420
cuguaggcac aguucagaca                                                   20


<210>  27421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27421
gaacugugcc uacagagacc                                                   20


<210>  27422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27422
ggcaggauuu gggacaugcu                                                   20


<210>  27423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27423
caaauccugc cagacggcca                                                   20


<210>  27424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27424
cugcuccagc augucccaaa                                                   20


<210>  27425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27425
caagcccgug gggaggcccu                                                   20


<210>  27426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27426
uccuugcugg gcagugggug                                                   20


<210>  27427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27427
ugcuagcaca gcacccacug                                                   20


<210>  27428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27428
gccuguccug cuagcacagc                                                   20


<210>  27429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27429
cugcaucccu ggagccuggc                                                   20


<210>  27430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27430
cacggggcac aggccugcaa                                                   20


<210>  27431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27431
cugcaccaac auaugugccu                                                   20


<210>  27432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27432
ggggccuguu cuggggcugc                                                   20


<210>  27433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27433
uccaugccca cagcaagagc                                                   20


<210>  27434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27434
aggaguugcg uuugggaugc                                                   20


<210>  27435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27435
gccccacgca ccauuucuac                                                   20


<210>  27436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27436
cgugccuccg agguggaggu                                                   20


<210>  27437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27437
caccuccacc ucggaggcac                                                   20


<210>  27438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27438
ccacgugguc ccaccuccac                                                   20


<210>  27439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27439
cuggcuacca gguccucacu                                                   20


<210>  27440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27440
ucacugugcc auggggaagg                                                   20


<210>  27441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27441
ggggaucaca gaaggcagca                                                   20


<210>  27442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27442
ugauggcaug ugccaugaag                                                   20


<210>  27443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27443
ccucuacuuc cugagugccc                                                   20


<210>  27444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27444
cucaacgagg cccuagauuc                                                   20


<210>  27445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27445
accuccccaa cgcccugccc                                                   20


<210>  27446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27446
agcagaggcu gaagggucag                                                   20


<210>  27447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27447
ggccagguug caggggccug                                                   20


<210>  27448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27448
ggccccacgc gggaguguag                                                   20


<210>  27449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27449
cccguuuuca gcugcgugaa                                                   20


<210>  27450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27450
ugugugccac ugcguuuuac                                                   20


<210>  27451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27451
agaggauagu ucucaaugag                                                   20


<210>  27452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27452
uccucugcac acggggagug                                                   20


<210>  27453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27453
aaacuggccc acugguauga                                                   20


<210>  27454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27454
ggaggaggca ugaacaccug                                                   20


<210>  27455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27455
cagguguuca ugccuccucc                                                   20


<210>  27456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27456
aagaaucgcu gcacagucuc                                                   20


<210>  27457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27457
ggaagugagg aguccacccc                                                   20


<210>  27458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27458
acccccucca ucauuuacca                                                   20


<210>  27459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27459
agcugagugu ggacagagug                                                   20


<210>  27460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27460
acacucagcu ugaccagcga                                                   20


<210>  27461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27461
uguucaaggg aggcaggagc                                                   20


<210>  27462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27462
cuugagugag caugcuccug                                                   20


<210>  27463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27463
aggucccuug agugagcaug                                                   20


<210>  27464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27464
ggguugaccg ucccuguggu                                                   20


<210>  27465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27465
acccugacca gguacuccag                                                   20


<210>  27466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27466
cuguggucac ucaucccaug                                                   20


<210>  27467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27467
cucaucccau guggcugagc                                                   20


<210>  27468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27468
ugggcaagca aggggcugau                                                   20


<210>  27469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27469
cuggagaucu gaaagcaggu                                                   20


<210>  27470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27470
agugaguccc uggagaucug                                                   20


<210>  27471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27471
acagagccua uuggguugua                                                   20


<210>  27472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27472
guccggguag aacuucagac                                                   20


<210>  27473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27473
ggguagaacu ucagacccua                                                   20


<210>  27474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27474
gaaguucuac ccggacugac                                                   20


<210>  27475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27475
ggggcugcag gauuaggguc                                                   20


<210>  27476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27476
gugauuguug cuauggagcg                                                   20


<210>  27477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27477
gcugaucccc uggcgcuguu                                                   20


<210>  27478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27478
ugccagugau uccccaccac                                                   20


<210>  27479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27479
ggcuguggug gggaaucacu                                                   20


<210>  27480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27480
uuggacccca gcacucaggu                                                   20


<210>  27481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27481
aaggaccacc agcucgccag                                                   20


<210>  27482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27482
acgcuacacc ugagugcugg                                                   20


<210>  27483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27483
cagugccugc ccaucucucc                                                   20


<210>  27484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27484
cugagcccuc aggagagaug                                                   20


<210>  27485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27485
uuccugcccc cugccacacc                                                   20


<210>  27486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27486
caaagaugca uguguggguu                                                   20


<210>  27487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27487
guggcuucug ccccccacca                                                   20


<210>  27488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27488
uugagaaaaa gcccuaccaa                                                   20


<210>  27489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27489
uggcgacaug guggaucugg                                                   20


<210>  27490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27490
ccaggacuga ggccugagag                                                   20


<210>  27491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27491
accugaguau gcucuugaga                                                   20


<210>  27492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27492
aacaguggag caagguccac                                                   20


<210>  27493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27493
guuuucaugu ugauuuuuuu                                                   20


<210>  27494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27494
cccaggcugg agugcaaugg                                                   20


<210>  27495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27495
cuacuaaaaa cacaaaaauu                                                   20


<210>  27496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27496
cgaacuccug aacucaagug                                                   20


<210>  27497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27497
auuuuuaaau gcaccucugc                                                   20


<210>  27498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27498
ccauaugcuc acugagcacc                                                   20


<210>  27499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27499
caguggugcu cagugagcau                                                   20


<210>  27500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27500
gccagucgca guggugcuca                                                   20


<210>  27501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27501
uggcgccucc cugugcccgu                                                   20


<210>  27502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27502
uggccuucaa ggggcuugug                                                   20


<210>  27503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27503
agugggccca augcuaggug                                                   20


<210>  27504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27504
agcggaaggc gugcaccaca                                                   20


<210>  27505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27505
ggagagcggu caagcggaag                                                   20


<210>  27506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27506
gcugcgaggu gccucccugu                                                   20


<210>  27507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27507
ucagagcggc ugccaugcca                                                   20


<210>  27508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27508
gcgggcgggu agagccagga                                                   20


<210>  27509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27509
caguuacaca cggcuggcau                                                   20


<210>  27510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27510
caucagugca cacaugccag                                                   20


<210>  27511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27511
ugguugacaa cagugccacg                                                   20


<210>  27512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27512
accaggacuu uuuucuuguu                                                   20


<210>  27513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27513
cuacagggcg ugggagccca                                                   20


<210>  27514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27514
cuacagggug ugggagccca                                                   20


<210>  27515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27515
agcucgugga ggcaggcugc                                                   20


<210>  27516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27516
caaaauucgu acuccaguug                                                   20


<210>  27517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27517
gagccuaagc aacuggagua                                                   20


<210>  27518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27518
cucacggccg agggucccuc                                                   20


<210>  27519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27519
cucccagccc ugauuucaca                                                   20


<210>  27520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27520
cugaccugcg ucccuccucc                                                   20


<210>  27521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27521
gagacuggca ccagcuccca                                                   20


<210>  27522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27522
cuccucccag gaucaggaaa                                                   20


<210>  27523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27523
agaaacuggg gcaggauccu                                                   20


<210>  27524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27524
ucuagaaacu ggggcaggau                                                   20


<210>  27525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27525
ugggguggga agaagucguc                                                   20


<210>  27526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27526
ucggagaguu ucuguccaac                                                   20


<210>  27527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27527
aaccagcagc cauaccccca                                                   20


<210>  27528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27528
gaggcaacuc caccuccagg                                                   20


<210>  27529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27529
ccccagcccu gacacucagg                                                   20


<210>  27530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27530
gggcuggggg gacgggaagc                                                   20


<210>  27531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27531
gaaacaccug caaggagcaa                                                   20


<210>  27532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27532
uccauggucc gggacugggu                                                   20


<210>  27533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27533
augguccggg acugggucau                                                   20


<210>  27534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27534
gggacugggu caugcugucc                                                   20


<210>  27535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27535
cggaccaugg acgacugccc                                                   20


<210>  27536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27536
ugcugucccu cuccaacuuc                                                   20


<210>  27537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27537
cucuccaacu ucacgcagag                                                   20


<210>  27538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27538
ccauggccac guggagccuc                                                   20


<210>  27539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27539
gcgcguccac cagcccgugg                                                   20


<210>  27540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27540
accagcccgu gggucgcggc                                                   20


<210>  27541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27541
cggcgaugua uccucucugg                                                   20


<210>  27542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27542
cuggugcugg ccccguuucc                                                   20


<210>  27543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27543
acaccgaggc ucauguuuca                                                   20


<210>  27544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27544
cccuggcauc ugugggguuu                                                   20


<210>  27545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27545
gcauuuuacu ucccuggggc                                                   20


<210>  27546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27546
agacauuugc ugaccagggc                                                   20


<210>  27547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27547
ggacgugcuc cuuucuguac                                                   20


<210>  27548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27548
gcaaaugucu ggacgugcuc                                                   20


<210>  27549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27549
cagcugaggg gccuuucugu                                                   20


<210>  27550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27550
cugcagacgu cccgcccacu                                                   20


<210>  27551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27551
gcagagacca ccgcccaccc                                                   20


<210>  27552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27552
cgcccacucg cgggcucugu                                                   20


<210>  27553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27553
ggagaagccc agccacacag                                                   20


<210>  27554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27554
uugugccucg aucgcccucu                                                   20


<210>  27555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27555
uggggaaggg cuguggaaag                                                   20


<210>  27556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27556
gucuugggga agggcugugg                                                   20


<210>  27557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27557
uggugcugac agcacagccu                                                   20


<210>  27558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27558
gcaccaggac aacugugcug                                                   20


<210>  27559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27559
agggagccug gagagcgagc                                                   20


<210>  27560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27560
acaaaggggu ccagggagcc                                                   20


<210>  27561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27561
ucaccuggga guuccucucc                                                   20


<210>  27562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27562
ucagcaggau gggcaagcug                                                   20


<210>  27563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27563
accugcucca gcuugcccau                                                   20


<210>  27564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27564
ccacagacuu cuacagacac                                                   20


<210>  27565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27565
guggcgacca ggcagaaaag                                                   20


<210>  27566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27566
guagaagucu guggcgacca                                                   20


<210>  27567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27567
agcuccuccu cuaucuggug                                                   20


<210>  27568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27568
gugcuugagg ugguugcagc                                                   20


<210>  27569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27569
gcagccggug auaugggcuu                                                   20


<210>  27570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27570
acaaggucac caccugcuga                                                   20


<210>  27571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27571
ccaccugcug agcgccaugg                                                   20


<210>  27572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27572
cucccaccau ggcgcucagc                                                   20


<210>  27573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27573
gcgcccuugu gcccugccuc                                                   20


<210>  27574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27574
cuaugggcuu ccgcacaugc                                                   20


<210>  27575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27575
cugccaugug gcagaagugc                                                   20


<210>  27576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27576
gcaguccugg uggggcugag                                                   20


<210>  27577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27577
ugguggggcu gagccugagg                                                   20


<210>  27578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27578
cccacauggg gugcagcaca                                                   20


<210>  27579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27579
uuucuccuga uagucaccug                                                   20


<210>  27580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27580
ccugcugguu guugccaggu                                                   20


<210>  27581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27581
ucccuccugc aggcuggcug                                                   20


<210>  27582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27582
ugcaguagaa ggugccguga                                                   20


<210>  27583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27583
cccugguggg gugugcaugc                                                   20


<210>  27584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27584
ggaugcacag augccauggc                                                   20


<210>  27585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27585
agcaccccca gccacuggcc                                                   20


<210>  27586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27586
caugcagcac aggccuugcg                                                   20


<210>  27587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27587
gggguggugg acagggcccc                                                   20


<210>  27588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27588
accaccccgg acgcugucgc                                                   20


<210>  27589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27589
gcgggugcuc aggagggcua                                                   20


<210>  27590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27590
ccuugugaau gcauaaacag                                                   20


<210>  27591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27591
ugcuguggcc accugcccac                                                   20


<210>  27592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27592
ucaguccugc uguggccacc                                                   20


<210>  27593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27593
gugcccgagg aggaggggcu                                                   20


<210>  27594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27594
ucugugcccg aggaggaggg                                                   20


<210>  27595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27595
uucuccaccc accagucagg                                                   20


<210>  27596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27596
gggacagcag ccucccuguc                                                   20


<210>  27597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27597
cugacuggug gguggagaac                                                   20


<210>  27598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27598
cucagcugag aaggccagcc                                                   20


<210>  27599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27599
agagacaugg gccucccacu                                                   20


<210>  27600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27600
cuggacacag uggaggcugc                                                   20


<210>  27601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27601
gccuaggagc uggcuggcag                                                   20


<210>  27602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27602
caacaccugc cagccagcuc                                                   20


<210>  27603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27603
cugagcugug uuuugucuga                                                   20


<210>  27604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27604
gagccucucu cggucaacag                                                   20


<210>  27605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27605
acagcaaagc uuggugucuu                                                   20


<210>  27606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27606
uggcacuguu agugacagag                                                   20


<210>  27607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27607
cuaacagugc caagacacca                                                   20


<210>  27608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27608
gcuggaacgg gggcagaagg                                                   20


<210>  27609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27609
ccgugcaaga ugucagcugg                                                   20


<210>  27610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27610
ggagagugca gaucugugcu                                                   20


<210>  27611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27611
ccgaugagca cagaucugca                                                   20


<210>  27612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27612
gagccgccac uccuaucccc                                                   20


<210>  27613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27613
cuggaccagc cuccuguuug                                                   20


<210>  27614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27614
agggaccugg ccuggggaua                                                   20


<210>  27615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27615
uuaaaaugga aguggauucu                                                   20


<210>  27616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27616
gcaagcagag cucccaaauc                                                   20


<210>  27617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27617
cacagccagu cggcaagcag                                                   20


<210>  27618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27618
ccaaccuugc cuggcucgcc                                                   20


<210>  27619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27619
uguggcuugg uuuggucaug                                                   20


<210>  27620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27620
ugcccgucga uguuuugggu                                                   20


<210>  27621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27621
auguuuuggg uauugaaugu                                                   20


<210>  27622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27622
caaggcagca ccugcacaga                                                   20


<210>  27623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27623
cucuccuaug uggcagcugg                                                   20


<210>  27624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27624
acaucucagc ugcuccccag                                                   20


<210>  27625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27625
uggcuggggg aggccucugu                                                   20


<210>  27626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27626
ucguggcggg gcagcaggag                                                   20


<210>  27627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27627
gauguuugag gaggcccuua                                                   20


<210>  27628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27628
gcagcucuga gacagcagua                                                   20


<210>  27629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27629
cagagcugcu gacauaaccu                                                   20


<210>  27630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27630
uccucuuguu uacgacguga                                                   20


<210>  27631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27631
uaaacaagag gaagacaaac                                                   20


<210>  27632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27632
uuagcaaggg gcucagaaca                                                   20


<210>  27633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27633
cccaccccca aagaccugcc                                                   20


<210>  27634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27634
uugggggugg gggacaccua                                                   20


<210>  27635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27635
uuuuuacuaa ugagcucaua                                                   20


<210>  27636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27636
auaugcacau gcauggauac                                                   20


<210>  27637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27637
ugagaggugu guguguaaaa                                                   20


<210>  27638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27638
guucuuccug gaaguugacu                                                   20


<210>  27639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27639
acuuccagga agaaccgaca                                                   20


<210>  27640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27640
aaggaaaguc aacuuccagg                                                   20


<210>  27641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27641
aguuagccgc gugacggaca                                                   20


<210>  27642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27642
cgcggcuaac uugaccuggc                                                   20


<210>  27643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27643
gucacgcggc uaacuugacc                                                   20


<210>  27644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27644
cacgccugga uguccgucac                                                   20


<210>  27645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27645
gggcagggcu cauucauugc                                                   20


<210>  27646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27646
ccauaucagc ucucugcaga                                                   20


<210>  27647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27647
uccucccuuc ugcagagagc                                                   20


<210>  27648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27648
aguuuugggg gugggcugug                                                   20


<210>  27649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27649
auguagguga uguuuccagc                                                   20


<210>  27650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27650
acccucauuu cugccagcgc                                                   20


<210>  27651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27651
uuucaagggg aaaaugugaa                                                   20


<210>  27652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27652
ggaggggguu cagcuucaca                                                   20


<210>  27653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27653
uuuagggcac agggccuucu                                                   20


<210>  27654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27654
uuucagagcc cucggagcca                                                   20


<210>  27655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27655
cgagcuccac guggggcuca                                                   20


<210>  27656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27656
acuauccguc ccgagcucca                                                   20


<210>  27657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27657
ggugggugga gucaggcuuc                                                   20


<210>  27658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27658
ggcuucucuu gcuaccugug                                                   20


<210>  27659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27659
gcugggaagg augcucacag                                                   20


<210>  27660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27660
cucccccgcu uccucccucu                                                   20


<210>  27661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27661
uccccgcaga gggaggaagc                                                   20


<210>  27662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27662
cggguccucc ccgcagaggg                                                   20


<210>  27663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27663
acccuggcca gcagcugugg                                                   20


<210>  27664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27664
uccagagggg ucacguguag                                                   20


<210>  27665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27665
cguguaggag ugagaagaag                                                   20


<210>  27666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27666
cucagcagcu cucaagaucu                                                   20


<210>  27667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27667
gagccauccu gagcucucca                                                   20


<210>  27668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27668
ucgucugagc cauccugagc                                                   20


<210>  27669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27669
ugcggcauuc ugagcagcuc                                                   20


<210>  27670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27670
cgcucuggug cagucaaagg                                                   20


<210>  27671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27671
aaggaacgcc uuccccucag                                                   20


<210>  27672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27672
cccgcugcaa ucuggguggu                                                   20


<210>  27673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27673
acguuggcca cgauccucca                                                   20


<210>  27674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27674
gagcccaccc uccguaggca                                                   20


<210>  27675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27675
aggucucacu gcuuugcacc                                                   20


<210>  27676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27676
cacugcuuug caccgugguc                                                   20


<210>  27677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27677
gagggacugu cagcugagcu                                                   20


<210>  27678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27678
cucugaccac ggugcaaagc                                                   20


<210>  27679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27679
gcugagcuug agcuccccug                                                   20


<210>  27680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27680
cggagcccca cccagaccug                                                   20


<210>  27681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27681
ggguggggcu ccgggacucg                                                   20


<210>  27682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27682
uucccuuugc ucucagaagc                                                   20


<210>  27683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27683
guccuucccu uugcucucag                                                   20


<210>  27684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27684
agguucucau gaagcaaagc                                                   20


<210>  27685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27685
uaggaagcag ucuccuaagu                                                   20


<210>  27686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27686
ccuaagugcu ucuccagcag                                                   20


<210>  27687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27687
caccagcuaa caucuggcau                                                   20


<210>  27688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27688
cccaggcagc ugccagcagg                                                   20


<210>  27689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27689
cugcuggcag cugccugggg                                                   20


<210>  27690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27690
uccugcccug cagaugggag                                                   20


<210>  27691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27691
agugacauca uaagcuuaua                                                   20


<210>  27692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27692
cuugaccaug aaggcuccag                                                   20


<210>  27693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27693
uauaagcuua ugaugucacu                                                   20


<210>  27694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27694
ugaggcuugu guaugucaua                                                   20


<210>  27695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27695
ucaggcccag cacagagacu                                                   20


<210>  27696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27696
cugugcuggg ccugaugacc                                                   20


<210>  27697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27697
auggccaagg agguggaagg                                                   20


<210>  27698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27698
cuggcccagc ugcucccagg                                                   20


<210>  27699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27699
gcagggccug ccccgucuau                                                   20


<210>  27700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27700
auucuagcuu guuuguccug                                                   20


<210>  27701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27701
ugucugaacc agcgccuacu                                                   20


<210>  27702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27702
gaaccagcgc cuacuccaag                                                   20


<210>  27703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27703
ggagcuuaga agcauccccg                                                   20


<210>  27704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27704
ucuugggaug cagaugucuu                                                   20


<210>  27705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27705
uaccaaccug caagaacaaa                                                   20


<210>  27706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27706
auguuugcug aggucccguc                                                   20


<210>  27707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27707
cgucugguuc uggcuaauug                                                   20


<210>  27708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27708
gguucuggcu aauuggcagg                                                   20


<210>  27709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27709
uccacccauu cuuucccugc                                                   20


<210>  27710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27710
acccauucuu ucccugcucu                                                   20


<210>  27711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27711
gugccaggag agacgggggc                                                   20


<210>  27712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27712
cuccuggcac agacagcaga                                                   20


<210>  27713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27713
gccaaggggc cagcuccugc                                                   20


<210>  27714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27714
gccggaggga ugugguggac                                                   20


<210>  27715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27715
accacauccc uccggcagac                                                   20


<210>  27716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27716
ccucauaggu gacaccgcuc                                                   20


<210>  27717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27717
ccuaugagga gacagauuua                                                   20


<210>  27718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27718
cuucagagaa auggagcacc                                                   20


<210>  27719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27719
agguguggac agccuggcac                                                   20


<210>  27720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27720
acaccuggac cagggagaag                                                   20


<210>  27721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27721
agugggaagc agcggugaac                                                   20


<210>  27722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27722
cuccccaugc cacggcagag                                                   20


<210>  27723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27723
ccuugccgag cugugcccug                                                   20


<210>  27724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27724
cuuccccugc guggugcgug                                                   20


<210>  27725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27725
gaugagggaa guagccaggg                                                   20


<210>  27726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27726
cuucaguggc ggcuccaccc                                                   20


<210>  27727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27727
caucauguag aggcaaggcc                                                   20


<210>  27728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27728
ucgguuggcu gugucacauc                                                   20


<210>  27729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27729
gguccaugag caccgugaca                                                   20


<210>  27730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27730
augagcaccg ugacaguguc                                                   20


<210>  27731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27731
cggugcucau ggaccagacu                                                   20


<210>  27732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27732
guggguagag guggacccgg                                                   20


<210>  27733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27733
accucuaccc acagacacug                                                   20


<210>  27734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27734
ucaccaggac cucuuuuggg                                                   20


<210>  27735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27735
uggugaugac acaaggccgg                                                   20


<210>  27736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27736
acaugguuuc ccaaaagagg                                                   20


<210>  27737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27737
cccaggcucu gcagccccag                                                   20


<210>  27738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27738
ucuguggcuc aagccacuug                                                   20


<210>  27739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27739
uguugcagcc acauccucug                                                   20


<210>  27740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27740
uggucggggg ugucugggcc                                                   20


<210>  27741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27741
ggggugucug ggcccugggu                                                   20


<210>  27742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27742
gggcccuggg ugggcccugu                                                   20


<210>  27743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27743
acagggccca cccagggccc                                                   20


<210>  27744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27744
gggucagggc aucacuggag                                                   20


<210>  27745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27745
gggcaucacu ggaggcagag                                                   20


<210>  27746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27746
ggguuccccu ugugugcaca                                                   20


<210>  27747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27747
ggcagcuacc cccaaaacug                                                   20


<210>  27748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27748
uagcaguuuu ggggguagcu                                                   20


<210>  27749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27749
ugagguggau ccuggccccu                                                   20


<210>  27750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27750
agaggguaca ggggccagga                                                   20


<210>  27751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27751
aggcuccgga gccugcccag                                                   20


<210>  27752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27752
ugggcccaaa ucacgggggg                                                   20


<210>  27753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27753
cacugagggg caccuuccag                                                   20


<210>  27754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27754
guccccaugu ccugcuggcc                                                   20


<210>  27755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27755
ccauguccug cuggccuguc                                                   20


<210>  27756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27756
ugcuggccug ucaggcaggg                                                   20


<210>  27757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27757
ggcagggcag aaaauccacc                                                   20


<210>  27758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27758
aguugggccc agccucauua                                                   20


<210>  27759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27759
caggucugca ccagggacag                                                   20


<210>  27760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27760
gcaccaggga cagcuccugc                                                   20


<210>  27761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27761
cuggugcaga ccugggacau                                                   20


<210>  27762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27762
ggccucggca ggagcugucc                                                   20


<210>  27763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27763
accagcagca ccugagggag                                                   20


<210>  27764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27764
ccuagggcca gaggcugguc                                                   20


<210>  27765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27765
cuacgggguc uccuagggcc                                                   20


<210>  27766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27766
cagcaggcca ugcagcuuug                                                   20


<210>  27767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27767
ccugcugggg aggggcucgu                                                   20


<210>  27768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27768
ccacaucugu ccccugcugg                                                   20


<210>  27769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27769
ucacauugga ggucagugug                                                   20


<210>  27770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27770
gugugagggc ucugccucgg                                                   20


<210>  27771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27771
agggccuccc augugcacug                                                   20


<210>  27772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27772
ggugggggcc cccggcagug                                                   20


<210>  27773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27773
acuggccagc agcugccccu                                                   20


<210>  27774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27774
uggcugaagg ggcagcugcu                                                   20


<210>  27775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27775
ggccuacugu ccuggcugaa                                                   20


<210>  27776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27776
ccagcagcuc caagguggau                                                   20


<210>  27777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27777
uggggccucu acgugcccuc                                                   20


<210>  27778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27778
gauccuguua ccccuguugu                                                   20


<210>  27779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27779
uccccacuaa ccuguuuccu                                                   20


<210>  27780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27780
uguccucccc acuaaccugu                                                   20


<210>  27781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27781
augcugaguc gcuagagcug                                                   20


<210>  27782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27782
cuagagcugc acccagaacc                                                   20


<210>  27783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27783
cagcaguggu ucugggugca                                                   20


<210>  27784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27784
uggcuacgga aagggcauuc                                                   20


<210>  27785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27785
gaaugcccuu uccguagcca                                                   20


<210>  27786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27786
cugaccucac cggggagggc                                                   20


<210>  27787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27787
gggaccgguc cgaaugcccu                                                   20


<210>  27788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27788
cuccuucauc ugcaggcacu                                                   20


<210>  27789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27789
gcccuccgug cugggggcug                                                   20


<210>  27790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27790
aguggagaug ccccagugcc                                                   20


<210>  27791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27791
ccugaggccc agauggaagg                                                   20


<210>  27792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27792
cuuccaucug ggccucagga                                                   20


<210>  27793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27793
agucccuucc aucugggccu                                                   20


<210>  27794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27794
cauggggcug augguggggc                                                   20


<210>  27795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27795
aggccuggcc ccaccaucag                                                   20


<210>  27796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27796
cuggucaagg ccuggcccca                                                   20


<210>  27797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27797
cugcaccccc uacacugggu                                                   20


<210>  27798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27798
ggauaggaag uguaugggga                                                   20


<210>  27799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27799
uuccccugag agccucgguc                                                   20


<210>  27800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27800
caccuccaag gugccucaga                                                   20


<210>  27801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27801
ucugaggcac cuuggaggug                                                   20


<210>  27802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27802
ccugcaguug gucaggccug                                                   20


<210>  27803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27803
ggccugagga gggcaggggg                                                   20


<210>  27804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27804
cucugcugac cacaguggca                                                   20


<210>  27805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27805
gcagagggac agcaggcacc                                                   20


<210>  27806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27806
augcugcaca ggugccgugg                                                   20


<210>  27807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27807
ggcagggcuc uguggagccc                                                   20


<210>  27808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27808
uccggccagc cugggggcau                                                   20


<210>  27809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27809
cucagcccca caggggccug                                                   20


<210>  27810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27810
ccgcacgcug ugccgaaucu                                                   20


<210>  27811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27811
ggguacgcag ggagcugaug                                                   20


<210>  27812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27812
caaacagagc ucaccuuugc                                                   20


<210>  27813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27813
ucaccggccg gugccagagg                                                   20


<210>  27814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27814
guguacccug ugucugcacc                                                   20


<210>  27815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27815
gcaccucugg gcagggccug                                                   20


<210>  27816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27816
gagccaggcc cugcccagag                                                   20


<210>  27817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27817
acagaccuaa ggcccagggc                                                   20


<210>  27818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27818
guggacacug gaagcccggg                                                   20


<210>  27819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27819
uggggcuggg cccucacaag                                                   20


<210>  27820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27820
ugggguccug gggcugggcc                                                   20


<210>  27821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27821
ugguccuggg guccuggggc                                                   20


<210>  27822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27822
cacagcccag gacccccacc                                                   20


<210>  27823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27823
ugggcugugg gacccuuaag                                                   20


<210>  27824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27824
cccaacgcug gccacuggcc                                                   20


<210>  27825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27825
cucguccucu cuguuucucc                                                   20


<210>  27826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27826
ucucuguuuc ucccaccuuu                                                   20


<210>  27827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27827
gugcagcccu gauuccugug                                                   20


<210>  27828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27828
cguuuccaua gcaacagagc                                                   20


<210>  27829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27829
uuuugauguc acguuuccau                                                   20


<210>  27830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27830
gauguaggcc ccauuuugag                                                   20


<210>  27831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27831
ccccaggcgg agaagcaccg                                                   20


<210>  27832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27832
aguugcgggc ccgccggugc                                                   20


<210>  27833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27833
guccaguugc gggcccgccg                                                   20


<210>  27834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27834
gggaggaguu cuucgacgag                                                   20


<210>  27835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27835
aagaacuccu cccagaccag                                                   20


<210>  27836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27836
gcuugagcuc gucgaagaac                                                   20


<210>  27837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27837
ucucgaagag cuugcuggcc                                                   20


<210>  27838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27838
uguuggugau cuugaucuug                                                   20


<210>  27839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27839
ugguggggcc cacacugccc                                                   20


<210>  27840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27840
ggagcggccc gccacgcccg                                                   20


<210>  27841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27841
ggacgaugug ugggucgugg                                                   20


<210>  27842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27842
cgacucagag cuccaagaaa                                                   20


<210>  27843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27843
uggccugccu gucggucucc                                                   20


<210>  27844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27844
gucuccucug gccggguaug                                                   20


<210>  27845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27845
ccucuggccg gguaugggca                                                   20


<210>  27846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27846
caccccgugg gguucugccc                                                   20


<210>  27847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27847
aagagcugag ggguagcagg                                                   20


<210>  27848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27848
ugggagccau ccuggccucu                                                   20


<210>  27849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27849
gggcacuguc ccucggaggc                                                   20


<210>  27850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27850
cucggaggca gcaacacuca                                                   20


<210>  27851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27851
gugggcacca ccaugagugu                                                   20


<210>  27852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27852
uuggggaaau ugagacugca                                                   20


<210>  27853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27853
caauuucccc aaugacgcag                                                   20


<210>  27854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27854
cagagcacug agccuccuuc                                                   20


<210>  27855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27855
cgguggggua uuuccagaaa                                                   20


<210>  27856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27856
ugcaccucac cuggugauuu                                                   20


<210>  27857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27857
ugggccaggg caggccucca                                                   20


<210>  27858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27858
ccuccggccu ucccugcagg                                                   20


<210>  27859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27859
aggaggggac aggugugguc                                                   20


<210>  27860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27860
ccuccuagac gccaacaucu                                                   20


<210>  27861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27861
cacacaccca gcaucuuaaa                                                   20


<210>  27862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27862
ccagcccauu aggacagggu                                                   20


<210>  27863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27863
uaaugggcug gggacccacg                                                   20


<210>  27864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27864
cgggugggca ggggucaugg                                                   20


<210>  27865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27865
ugguggggug aaggucucag                                                   20


<210>  27866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27866
caggcacagg caaggucaca                                                   20


<210>  27867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27867
caggugcggu gagggucuug                                                   20


<210>  27868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27868
ugcagggugu gaaggucaua                                                   20


<210>  27869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27869
uaggugugcg gugaagguca                                                   20


<210>  27870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27870
cagguguggg gugaugguuu                                                   20


<210>  27871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27871
ugcacggagc gaggguggca                                                   20


<210>  27872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27872
aggccgccca cagggccggg                                                   20


<210>  27873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27873
gcuuccagga ugggaguggc                                                   20


<210>  27874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27874
ggcaggugag ccuggggcag                                                   20


<210>  27875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27875
ccagcccuag ugggaguggg                                                   20


<210>  27876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27876
ggggccuugc ugggccucuu                                                   20


<210>  27877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27877
guccggggcc uugcugggcc                                                   20


<210>  27878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27878
ccgcuuucag uugcguugau                                                   20


<210>  27879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27879
ggggccuggc ccugcccaaa                                                   20


<210>  27880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27880
cggcuuuggg gccugccuag                                                   20


<210>  27881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27881
ugcucagcac ccuagguccc                                                   20


<210>  27882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27882
caagccagcc gcucaaaccc                                                   20


<210>  27883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27883
accgaaccuc ugaagauacc                                                   20


<210>  27884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27884
ugcucaggca ccuggugagg                                                   20


<210>  27885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27885
cuuccucacc aggugccuga                                                   20


<210>  27886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27886
uggccaccuc ccacugcccu                                                   20


<210>  27887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27887
gaggggagcc ugcuggaaca                                                   20


<210>  27888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27888
ggccagguua uucauuauuu                                                   20


<210>  27889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27889
caggggaggg uuucugucuc                                                   20


<210>  27890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27890
ccauuccugg aggcugagag                                                   20


<210>  27891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27891
ggaguggagg cccccacucu                                                   20


<210>  27892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27892
gggcuggcca agggcugcac                                                   20


<210>  27893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27893
uggcugauga agcacuucca                                                   20


<210>  27894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27894
gccuuaguuc accgaggggg                                                   20


<210>  27895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27895
cucucaugcu cugggccuca                                                   20


<210>  27896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27896
uuagcagagg aagcuguggc                                                   20


<210>  27897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27897
cccagccaca gcuuccucug                                                   20


<210>  27898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27898
uuuuucuuua uacccgcagu                                                   20


<210>  27899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27899
ccccauagca gaggcuuuuc                                                   20


<210>  27900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27900
ucacagccac gugccacccu                                                   20


<210>  27901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27901
ccucucuccu acucuugcua                                                   20


<210>  27902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27902
cucaaaggca gaguggggag                                                   20


<210>  27903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27903
agugaggcag agaugccccu                                                   20


<210>  27904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27904
ggccgccaug gggcccugug                                                   20


<210>  27905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27905
ccugccuuga ccucccagag                                                   20


<210>  27906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27906
aggcaggaga cacagggccc                                                   20


<210>  27907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27907
ccaggccucc ccugggccuc                                                   20


<210>  27908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27908
ugcccugaga ggcuaagucc                                                   20


<210>  27909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27909
gcaggaguag gugggugcug                                                   20


<210>  27910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27910
cagugguaau gaggcaucag                                                   20


<210>  27911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27911
gggcaggagc cuagauccag                                                   20


<210>  27912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27912
uugauauaaa aauagaggcu                                                   20


<210>  27913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27913
cacagcaaag uguggagaug                                                   20


<210>  27914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27914
guaucucauc uccacacuuu                                                   20


<210>  27915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27915
acagcccuga gucaguaucu                                                   20


<210>  27916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27916
cucccugagg cauucucucc                                                   20


<210>  27917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27917
agaaacuaua gaaaagcaag                                                   20


<210>  27918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27918
uauugcuuuu cccuugcuuu                                                   20


<210>  27919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27919
cagcaugcac agauaaccuu                                                   20


<210>  27920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27920
caguauuacu aagguuaucu                                                   20


<210>  27921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27921
ugaagcccag cuucuuucua                                                   20


<210>  27922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27922
auugucaucu ugacccugga                                                   20


<210>  27923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27923
ucuugacccu ggagccuggc                                                   20


<210>  27924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27924
agaugacaau ggacuuagaa                                                   20


<210>  27925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27925
ugcccagccu cagcagaggg                                                   20


<210>  27926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27926
cucguuucag gaaauuaaaa                                                   20


<210>  27927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27927
ugcauuuuaa uuuccugaaa                                                   20


<210>  27928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27928
gccccgcccg acuggcccua                                                   20


<210>  27929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27929
ggcggggcgg acucgcuauc                                                   20


<210>  27930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27930
ccgaguccug ugauggcaaa                                                   20


<210>  27931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27931
ugugauggca aacugccgga                                                   20


<210>  27932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27932
ggcaguuugc caucacagga                                                   20


<210>  27933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27933
cagaccgagg cgucccuguc                                                   20


<210>  27934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27934
gggacgugga gggccccggc                                                   20


<210>  27935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27935
cugucgccgc ccgcuaaguc                                                   20


<210>  27936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27936
ccgcccgcua aguccacccc                                                   20


<210>  27937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27937
accccucugu acuucccgua                                                   20


<210>  27938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27938
gagcgaucau ccucgaagcg                                                   20


<210>  27939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27939
cuuaaguuca gguagugugu                                                   20


<210>  27940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27940
gcuuguccuu ccccugcccu                                                   20


<210>  27941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27941
uuccccugcc cugggguauc                                                   20


<210>  27942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27942
cuuucucuaa augguggggg                                                   20


<210>  27943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27943
cuggaggcgc ugcccgcagc                                                   20


<210>  27944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27944
gaggccgccu gucccuggag                                                   20


<210>  27945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27945
acaggcagac cgaguuuguc                                                   20


<210>  27946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27946
gccuguggac acuaaagccc                                                   20


<210>  27947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27947
cccagcucca ucacuuuuga                                                   20


<210>  27948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27948
aggaacuuuc cgugcagcuc                                                   20


<210>  27949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27949
cccuccuaua aaaugggggu                                                   20


<210>  27950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27950
ucucuccugu gaugcuccca                                                   20


<210>  27951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27951
cccuccgugu gccgggcccc                                                   20


<210>  27952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27952
ggggcuuggu cucccuccgu                                                   20


<210>  27953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27953
gugugggcua agggaggcca                                                   20


<210>  27954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27954
ggcugcaccu caucacgugu                                                   20


<210>  27955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27955
ugcccacggc aacacgugau                                                   20


<210>  27956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27956
ccucugccau ccaucccaca                                                   20


<210>  27957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27957
gagguguggg auggauggca                                                   20


<210>  27958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27958
cgugcuggcc acgugacugu                                                   20


<210>  27959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27959
cguggccagc acgggacggg                                                   20


<210>  27960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27960
ugcaugcugc cuggcucccg                                                   20


<210>  27961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27961
guccugcaug cugccuggcu                                                   20


<210>  27962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27962
ccuccucaaa agcaccuucu                                                   20


<210>  27963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27963
cagcuucucc ccugcccugg                                                   20


<210>  27964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27964
ucaagucuuu cugacaggag                                                   20


<210>  27965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27965
uucugacagg aggugucaga                                                   20


<210>  27966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27966
gaaagacuug aagaccaggg                                                   20


<210>  27967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27967
gaaaaguauc uuuaguagag                                                   20


<210>  27968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27968
ccgaggaggg ucccucucau                                                   20


<210>  27969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27969
cucucaugcc gggggccgcu                                                   20


<210>  27970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27970
agcagcggcc cccggcauga                                                   20


<210>  27971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27971
ucaaugagaa auccugaguc                                                   20


<210>  27972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27972
caggucuuca augagaaauc                                                   20


<210>  27973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27973
acgggaacaa cagccacaaa                                                   20


<210>  27974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27974
gagaacuggg cucaguccac                                                   20


<210>  27975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27975
ugugcaaggc cccaggcagc                                                   20


<210>  27976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27976
guggguuuug gcagcucccu                                                   20


<210>  27977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27977
gcugagacca cggguggccc                                                   20


<210>  27978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27978
cagcagaccu cccugaaggg                                                   20


<210>  27979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27979
agcccugugg gcgccuccug                                                   20


<210>  27980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27980
uggggagaga gcccaggccu                                                   20


<210>  27981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27981
uucugccucu cuaccaaggu                                                   20


<210>  27982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27982
cagaaggaag ggccugagau                                                   20


<210>  27983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27983
uggcuucccu acaggggucc                                                   20


<210>  27984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27984
ugaguacucu gcacuaccca                                                   20


<210>  27985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27985
cuccaccccu ggcccccaac                                                   20


<210>  27986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27986
ggaaagggug ggauguucug                                                   20


<210>  27987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27987
ugggacccug gucauugggg                                                   20


<210>  27988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27988
caggacaauc cacaccccuu                                                   20


<210>  27989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27989
uuggggucau ccgcuagucg                                                   20


<210>  27990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27990
uccgcuaguc gcaaaggacg                                                   20


<210>  27991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27991
caaaggacgg caaugccugu                                                   20


<210>  27992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27992
uuugcgacua gcggaugacc                                                   20


<210>  27993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27993
caaaaaaaaa aaaaaagaaa                                                   20


<210>  27994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27994
cgcucuugug cagagagcag                                                   20


<210>  27995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27995
ugaacuccug accucaggug                                                   20


<210>  27996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27996
ggaguucaag accagccugg                                                   20


<210>  27997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27997
aaggcggugg guucuggccc                                                   20


<210>  27998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27998
cauauuccau gugcaaagga                                                   20


<210>  27999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  27999
cuuacucagg gucucauauu                                                   20


<210>  28000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28000
ggucacuuac ucagggucuc                                                   20


<210>  28001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28001
ggaggguccg gugaggcccc                                                   20


<210>  28002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28002
ggugaggccc cuggugugcc                                                   20


<210>  28003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28003
acagccggca cuguccuucc                                                   20


<210>  28004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28004
uuccaggucg gaggagcggc                                                   20


<210>  28005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28005
gaggagcggc cggugaagaa                                                   20


<210>  28006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28006
ccuccacggc gcggcucagc                                                   20


<210>  28007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28007
agcacgcggc gcaccucgcg                                                   20


<210>  28008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28008
gcuggagagg aucaucacca                                                   20


<210>  28009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28009
agcgucuagg ccagcaggcg                                                   20


<210>  28010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28010
aggccagcag gcggcggcgg                                                   20


<210>  28011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28011
ccgcucgcgg ggcggccccc                                                   20


<210>  28012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28012
cuucugaggg guauuuugag                                                   20


<210>  28013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28013
ccagggccug gggguuccuc                                                   20


<210>  28014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28014
ccagcaugaa ugcccuuccu                                                   20


<210>  28015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28015
gaggaagggc auucaugcug                                                   20


<210>  28016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28016
uagagccacu cuccaguguc                                                   20


<210>  28017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28017
uuacuaucaa ugauacuuga                                                   20


<210>  28018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28018
aguaucauug auaguaacga                                                   20


<210>  28019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28019
ucccucacca ggaccucugc                                                   20


<210>  28020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28020
uggugaggga ggacacaggg                                                   20


<210>  28021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28021
cuccuuaaau ggccucugac                                                   20


<210>  28022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28022
gaggccauuu aaggagagac                                                   20


<210>  28023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28023
cugggguuuu caucaggcgu                                                   20


<210>  28024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28024
uugcuaagga ggcaguggaa                                                   20


<210>  28025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28025
uaacaccugu ucacaugcac                                                   20


<210>  28026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28026
uccaccauga uaucuccagc                                                   20


<210>  28027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28027
uccccgcaug ggagcauaag                                                   20


<210>  28028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28028
guagagaaau gguugcaggu                                                   20


<210>  28029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28029
ucaggccaac cccucccuuc                                                   20


<210>  28030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28030
gccuccgugu ccucaggcca                                                   20


<210>  28031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28031
ucugccucug ggccuucgca                                                   20


<210>  28032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28032
uuuggccagu gcagcucugg                                                   20


<210>  28033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28033
gacaucggug ggggacagag                                                   20


<210>  28034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28034
gacccagagc ugcacuggcc                                                   20


<210>  28035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28035
cccaccgaug ucagacccag                                                   20


<210>  28036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28036
cggccaagga ggcucauaga                                                   20


<210>  28037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28037
gguugcccug gcugcaaagg                                                   20


<210>  28038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28038
ccuccuggaa uuaggcaagu                                                   20


<210>  28039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28039
gcaggugaac agcaugguuu                                                   20


<210>  28040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28040
aaccaugcug uucaccugcu                                                   20


<210>  28041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28041
ccacggccug cucgcuuggc                                                   20


<210>  28042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28042
uccugcgaca agcagcagca                                                   20


<210>  28043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28043
caggaugacu gcagcacugc                                                   20


<210>  28044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28044
ugaggucagc caggcaagag                                                   20


<210>  28045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28045
gccaggcaag agagcagcuu                                                   20


<210>  28046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28046
aagcugcucu cuugccuggc                                                   20


<210>  28047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28047
cacacccagu ggaguccaag                                                   20


<210>  28048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28048
acaggcuggu cccacaccca                                                   20


<210>  28049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28049
uggagcuccc acccuccuca                                                   20


<210>  28050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28050
ucggcacaca ggcucugggg                                                   20


<210>  28051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28051
ugagggugua aggagcggcg                                                   20


<210>  28052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28052
ucuggcagcu ggaaacuggc                                                   20


<210>  28053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28053
gcggcgucau cuggcagcug                                                   20


<210>  28054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28054
uccuggggcc acccuuccuu                                                   20


<210>  28055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28055
cggagcugga aacuggcuag                                                   20


<210>  28056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28056
ugccuacgag gcgggugggu                                                   20


<210>  28057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28057
aguuggagcc caguguguuu                                                   20


<210>  28058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28058
uggcuggguu cccagcaucu                                                   20


<210>  28059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28059
gcagcugggg gcaggugccu                                                   20


<210>  28060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28060
caagcccucg agagggaagg                                                   20


<210>  28061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28061
agccuaaccu uccugccagg                                                   20


<210>  28062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28062
ugugggagcg uccagccuaa                                                   20


<210>  28063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28063
gccaugacgc accgguacuu                                                   20


<210>  28064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28064
uggcugacuc uacagcaguu                                                   20


<210>  28065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28065
cggaugccug gcaguuacug                                                   20


<210>  28066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28066
cugcugugcu uggguuagaa                                                   20


<210>  28067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28067
guuuucuucu cgcccucucu                                                   20


<210>  28068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28068
gugauucaug cccuuccauc                                                   20


<210>  28069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28069
ggcagcgccu gccccuucuc                                                   20


<210>  28070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28070
gcagaacuca gcuguagaau                                                   20


<210>  28071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28071
uuaacaacuu ucugauuucu                                                   20


<210>  28072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28072
auuaaggaga aaaaaaauga                                                   20


<210>  28073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28073
aaacaacaug aaauacuaca                                                   20


<210>  28074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28074
ggaguucaag accagccuga                                                   20


<210>  28075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28075
ugaacuccug accucagagg                                                   20


<210>  28076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28076
ggcuggucuu gaacuccuga                                                   20


<210>  28077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28077
uuacuaaaaa uacaaaauua                                                   20


<210>  28078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28078
cccaggcugg agugcagugg                                                   20


<210>  28079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28079
caaaaaaaaa aaaaaauuaa                                                   20


<210>  28080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28080
uuuguacauu uggcuuucug                                                   20


<210>  28081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28081
uguuccuucu ggguuaaauu                                                   20


<210>  28082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28082
uacugaaaaa ucuaaauaau                                                   20


<210>  28083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28083
augucaucau uuuauuaaug                                                   20


<210>  28084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28084
ucauuuuauu aaugucauuc                                                   20


<210>  28085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28085
uuccaaacau agucucaaua                                                   20


<210>  28086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28086
caauaauauc acuucuuggu                                                   20


<210>  28087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28087
aaaccaagaa gugauauuau                                                   20


<210>  28088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28088
augucaaaac caagaaguga                                                   20


<210>  28089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28089
aaggccaguc agcgugagaa                                                   20


<210>  28090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28090
gcgugagaag accgcucggc                                                   20


<210>  28091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28091
ucucacgcug acuggccuug                                                   20


<210>  28092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28092
gggaguugga accgcagacu                                                   20


<210>  28093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28093
gcgguuccaa cuccccgacu                                                   20


<210>  28094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28094
uggccuccag cagccacaug                                                   20


<210>  28095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28095
ggaaauggag acuccugcgu                                                   20


<210>  28096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28096
ccauuucccg acguucgucc                                                   20


<210>  28097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28097
cguccuaaag cugaagaaac                                                   20


<210>  28098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28098
uaaagcugaa gaaacgcauu                                                   20


<210>  28099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28099
gugccacucc uagacaggcc                                                   20


<210>  28100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28100
aggaguggca cugaccagag                                                   20


<210>  28101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28101
ucaaacuggu cugaggaccc                                                   20


<210>  28102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28102
gaggaccccu caacgcucuu                                                   20


<210>  28103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28103
ucagaccagu uugaggacgg                                                   20


<210>  28104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28104
uggccuccca aagugcuggg                                                   20


<210>  28105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28105
ggacauugag aucauccugg                                                   20


<210>  28106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28106
ugaccucgug auccgccugu                                                   20


<210>  28107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28107
cuacuaaaaa uacaaaaaau                                                   20


<210>  28108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28108
cagcuacuug ggaggcugag                                                   20


<210>  28109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28109
cgcucugcug cccaggcugg                                                   20


<210>  28110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28110
caaaaaaaaa uaauaaauaa                                                   20


<210>  28111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28111
uuagaacuca cauaagcaaa                                                   20


<210>  28112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28112
cagguuuaau uucuaauaag                                                   20


<210>  28113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28113
uggguuuauu gcuauuuuga                                                   20


<210>  28114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28114
uaaaucucug gcuuaagaga                                                   20


<210>  28115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28115
guccacuuug gggguguuuu                                                   20


<210>  28116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28116
acuuuggggg uguuuugguu                                                   20


<210>  28117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28117
aguguuggaa uaggaucacg                                                   20


<210>  28118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28118
ccaaaaaaaa aaaacaaacc                                                   20


<210>  28119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28119
cgcucuguca cucaggcugg                                                   20


<210>  28120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28120
cucaggcugg agugcagugg                                                   20


<210>  28121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28121
cagcuacuca ggaggcugag                                                   20


<210>  28122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28122
caaucuccug acaucgugau                                                   20


<210>  28123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28123
ggagauugag accauccugg                                                   20


<210>  28124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28124
gccgggcuaa caccuguaau                                                   20


<210>  28125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28125
gucuugugcu ucaaggacuc                                                   20


<210>  28126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28126
ugugcuucaa ggacucuguc                                                   20


<210>  28127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28127
uugaagcaca agacggacca                                                   20


<210>  28128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28128
aucaugccuu ugugaccuca                                                   20


<210>  28129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28129
caaaggcaug auggacagag                                                   20


<210>  28130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28130
gcauuuggaa uauccgcaua                                                   20


<210>  28131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28131
uucaguugga aaggugguga                                                   20


<210>  28132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28132
uucagaauuc ugauuuuugc                                                   20


<210>  28133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28133
gcuauuuucu uugaaugaga                                                   20


<210>  28134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28134
cauucaaaga aaauagcuga                                                   20


<210>  28135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28135
gccaggacac ccaaggcuga                                                   20


<210>  28136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28136
uggcagacuu uuuuuuuuug                                                   20


<210>  28137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28137
ggaucuggaa cacacguaug                                                   20


<210>  28138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28138
acgcugagga aaugcaggug                                                   20


<210>  28139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28139
ugcccgagca acuggaaggc                                                   20


<210>  28140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28140
acaucuuuuc aacguccugc                                                   20


<210>  28141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28141
agaccucaca cacucgacca                                                   20


<210>  28142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28142
ugaccccugg guccacaucu                                                   20


<210>  28143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28143
agugugugag gucuugaccc                                                   20


<210>  28144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28144
gugauggagu gaaaaugguc                                                   20


<210>  28145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28145
cuuccaaaug uccgugaugg                                                   20


<210>  28146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28146
ugccacauca gugcgcaugu                                                   20


<210>  28147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28147
gcuccgugaa gaccccguga                                                   20


<210>  28148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28148
ucacggagcu gacaugcgca                                                   20


<210>  28149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28149
ucacgggguc uucacggagc                                                   20


<210>  28150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28150
gaugaucacg gggucuucac                                                   20


<210>  28151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28151
cugagguugc agcugcuuuc                                                   20


<210>  28152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28152
ccaagggucc cugagguugc                                                   20


<210>  28153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28153
cggccugugg gucaccaagg                                                   20


<210>  28154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28154
ccugugugcc cgcuccagca                                                   20


<210>  28155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28155
guccuugccc gguacccaga                                                   20


<210>  28156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28156
uugcccggua cccagagcug                                                   20


<210>  28157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28157
accaaucgcc agugagccag                                                   20


<210>  28158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28158
cacaaagggg cccuccgugu                                                   20


<210>  28159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28159
cacggagggc cccuuugugu                                                   20


<210>  28160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28160
ucacagacag cgugugggaa                                                   20


<210>  28161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28161
gugaugacgc cacccaguca                                                   20


<210>  28162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28162
cucugggccc gcuugggggc                                                   20


<210>  28163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28163
uguaggcacu ggggauaggg                                                   20


<210>  28164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28164
gguggaaagc agauacaaau                                                   20


<210>  28165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28165
uuacaggguu ucgaguugag                                                   20


<210>  28166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28166
agccccaccc ucaacucgaa                                                   20


<210>  28167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28167
aguauguuag aagagaggug                                                   20


<210>  28168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28168
ugugagcgga uggaguggga                                                   20


<210>  28169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28169
aggugggagc uggcucugag                                                   20


<210>  28170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28170
aggcccaccu cgcccucaga                                                   20


<210>  28171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28171
cuguccaggc ccaccucgcc                                                   20


<210>  28172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28172
cagcagaaag cagggugucc                                                   20


<210>  28173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28173
cggagcaggg agggucaggu                                                   20


<210>  28174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28174
gguguggcgu ggagccuggg                                                   20


<210>  28175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28175
aaccauucua uccuccccua                                                   20


<210>  28176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28176
uggagauggc cacgagcgca                                                   20


<210>  28177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28177
ggagggagag ggcacccuac                                                   20


<210>  28178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28178
ccaggggcuu ccaacuggcu                                                   20


<210>  28179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28179
guucuuggcu ucuauuuuag                                                   20


<210>  28180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28180
cucacagaug ugucaguucu                                                   20


<210>  28181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28181
ugucccucac agauguguca                                                   20


<210>  28182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28182
cugcacaagc cacggaugua                                                   20


<210>  28183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28183
cacuucccug agcugagggg                                                   20


<210>  28184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28184
accuggugcc uuucgcugcc                                                   20


<210>  28185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28185
aggcuaaucu gcucuccugc                                                   20


<210>  28186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28186
agaccuugag cgccucgucc                                                   20


<210>  28187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28187
ggacauggug gugcagagca                                                   20


<210>  28188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28188
cccacaaaug ucauauuuac                                                   20


<210>  28189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28189
uauuuacccc cuagaggacc                                                   20


<210>  28190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28190
ucuagggggu aaauaugaca                                                   20


<210>  28191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28191
ucuagguccu cuagggggua                                                   20


<210>  28192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28192
caggucugcc cuccccguug                                                   20


<210>  28193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28193
gcccuccccg uuggggccaa                                                   20


<210>  28194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28194
ggcacuuggc cccaacgggg                                                   20


<210>  28195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28195
cagccuuucu uagggagugc                                                   20


<210>  28196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28196
ucucucgccc ugggcacacc                                                   20


<210>  28197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28197
ggggucuugg acagcucuuc                                                   20


<210>  28198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28198
uggacagcuc uuccuaggag                                                   20


<210>  28199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28199
aagaccccag acauccccuc                                                   20


<210>  28200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28200
cggaggaagc ccugcagcuu                                                   20


<210>  28201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28201
gaucucacag agacugugug                                                   20


<210>  28202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28202
cugugagauc ggacucaggc                                                   20


<210>  28203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28203
cgagggcgag cagcagcuca                                                   20


<210>  28204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28204
guccccugcc caggcuuuuc                                                   20


<210>  28205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28205
ccugcccagg cuuuucucgc                                                   20


<210>  28206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28206
ucucgugggu cccuuacuga                                                   20


<210>  28207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28207
cuuacugaug gagagacugu                                                   20


<210>  28208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28208
cuccaucagu aagggaccca                                                   20


<210>  28209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28209
cucuguguac uuguguacac                                                   20


<210>  28210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28210
cauccuucaa aacucacuag                                                   20


<210>  28211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28211
ggcuacaaau ggcuuacacg                                                   20


<210>  28212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28212
gguugagauu uacuuuuuuc                                                   20


<210>  28213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28213
ugucgcuaug gaguggcuuu                                                   20


<210>  28214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28214
cuauggagug gcuuuggacu                                                   20


<210>  28215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28215
aaagccacuc cauagcgaca                                                   20


<210>  28216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28216
ggcccgcucu ggagucugca                                                   20


<210>  28217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28217
ccauucaugu uaugaaccaa                                                   20


<210>  28218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28218
aaggccaauu ucugacgcua                                                   20


<210>  28219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28219
gaaauuggcc uuggacacuc                                                   20


<210>  28220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28220
guagaacacu ccagaaugua                                                   20


<210>  28221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28221
uggcagaugg ugucaguaga                                                   20


<210>  28222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28222
gcucuagaag cacacaggug                                                   20


<210>  28223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28223
gaggugaggc agcggggauu                                                   20


<210>  28224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28224
gggccauggu uggcagaggc                                                   20


<210>  28225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28225
ggagaagcaa gacagggaug                                                   20


<210>  28226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28226
ugcuucuccu gaccaucagu                                                   20


<210>  28227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28227
gcuccuccug cugugugcag                                                   20


<210>  28228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28228
gcagggcccg gcaggaagga                                                   20


<210>  28229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28229
gggcugguca gcagggcccg                                                   20


<210>  28230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28230
gcagccgggg cagccagcug                                                   20


<210>  28231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28231
caugagacaa gugagauacc                                                   20


<210>  28232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28232
caugggaccc ugcaggcucc                                                   20


<210>  28233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28233
guuugcgcaa gaagcaauau                                                   20


<210>  28234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28234
ggcucuccau cggccuucua                                                   20


<210>  28235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28235
ugagggugag ggccacgccc                                                   20


<210>  28236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28236
ccugggccug gcugcuucug                                                   20


<210>  28237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28237
cccacagaag cagccaggcc                                                   20


<210>  28238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28238
uuuucaacac ucccuccccu                                                   20


<210>  28239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28239
cacugucacc ugggccuccu                                                   20


<210>  28240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28240
ccugggccuc cugggccagc                                                   20


<210>  28241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28241
gcuggcccag gaggcccagg                                                   20


<210>  28242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28242
gcaaaguucc ccaagaagga                                                   20


<210>  28243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28243
ccaggcugcc gacauugcag                                                   20


<210>  28244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28244
gcagccuggg gacagcccug                                                   20


<210>  28245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28245
aguccuaggc acacaccauu                                                   20


<210>  28246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28246
uaggcacaca ccauugucac                                                   20


<210>  28247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28247
cuucaccagg cuccacgggg                                                   20


<210>  28248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28248
ccagaucugg ggccccgugg                                                   20


<210>  28249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28249
agucaccgga cucugcggac                                                   20


<210>  28250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28250
ccggacucug cggacacaga                                                   20


<210>  28251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28251
ggugacugga caguccccag                                                   20


<210>  28252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28252
gcagaguccg gugacuggac                                                   20


<210>  28253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28253
aaucugaccc cauccugccu                                                   20


<210>  28254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28254
gauuugacuc uguguccgca                                                   20


<210>  28255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28255
ggguacacug ggccuguggg                                                   20


<210>  28256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28256
augaggaggg cagggcagcc                                                   20


<210>  28257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28257
ugcucagccc uagacuggcu                                                   20


<210>  28258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28258
agggcugagc aagaccugag                                                   20


<210>  28259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28259
gagccagucu agggcugagc                                                   20


<210>  28260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28260
ggaccccaca gcagcagggc                                                   20


<210>  28261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28261
ugaccucacc ccaccacguu                                                   20


<210>  28262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28262
uccugggugg cccugcugcu                                                   20


<210>  28263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28263
caggcugugg cccauguacc                                                   20


<210>  28264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28264
ccaagucagg aggaaggagg                                                   20


<210>  28265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28265
ggaggaagga ggccaggagu                                                   20


<210>  28266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28266
uacugcucgg gguccagguu                                                   20


<210>  28267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28267
agguucuggg gcucuguccu                                                   20


<210>  28268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28268
ucugcgagca ccucucagcc                                                   20


<210>  28269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28269
gugcagcacu guggggaagg                                                   20


<210>  28270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28270
aacccugcgg ggaacuaagg                                                   20


<210>  28271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28271
ggagucuaac ccugcgggga                                                   20


<210>  28272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28272
ggaguccggc cucccccaac                                                   20


<210>  28273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28273
ggccuccccc aacagcccac                                                   20


<210>  28274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28274
gccccguggu ugaauccaaa                                                   20


<210>  28275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28275
uuuccuguuc aaagaacuuu                                                   20


<210>  28276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28276
cuugaaaguu cuuugaacag                                                   20


<210>  28277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28277
cuguaauuua augauaauug                                                   20


<210>  28278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28278
cauuuucucc cuuacaggca                                                   20


<210>  28279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28279
uggucaggug gaggagaccu                                                   20


<210>  28280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28280
gguggaggag accugugucc                                                   20


<210>  28281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28281
ccuccaccug accaggacgg                                                   20


<210>  28282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28282
uggacuuugg accccgaggc                                                   20


<210>  28283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28283
aggacacagg ucuccuccac                                                   20


<210>  28284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28284
aaaguccagg acacaggucu                                                   20


<210>  28285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28285
accugcccca cagccacagc                                                   20


<210>  28286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28286
cacuugauaa gaacugacau                                                   20


<210>  28287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28287
uuauucacac acagauaaga                                                   20


<210>  28288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28288
uuuauuucuc uuucuugccu                                                   20


<210>  28289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28289
guguucauga gggucauugg                                                   20


<210>  28290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28290
uugggcugua auuucuuuuu                                                   20


<210>  28291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28291
uugucagguu uugauaucag                                                   20


<210>  28292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28292
gguuuugaua ucagaguuac                                                   20


<210>  28293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28293
uucccuuccu ucuauuuacu                                                   20


<210>  28294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28294
aacaagauau cacaaagaaa                                                   20


<210>  28295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28295
uuuagcauuu aaugagauuu                                                   20


<210>  28296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28296
ucuauaugug uuaauuaggu                                                   20


<210>  28297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28297
gguuuuccca acaauuuaua                                                   20


<210>  28298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28298
uuuuuggcuu gacuuucuuu                                                   20


<210>  28299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28299
agccaaaaau gacacuauca                                                   20


<210>  28300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28300
acuugucuug uuuuucuuca                                                   20


<210>  28301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28301
uguuuuucuu cauauuucua                                                   20


<210>  28302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28302
cuacaggauc gcguggcagu                                                   20


<210>  28303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28303
aggggaggcu guggaggcug                                                   20


<210>  28304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28304
caucuuuggg aagaugcaga                                                   20


<210>  28305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28305
agauguccca ucuuugggaa                                                   20


<210>  28306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28306
aauaugauac acauugaguc                                                   20


<210>  28307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28307
acuaaaugcu guuaaagcaa                                                   20


<210>  28308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28308
accuucuuuu cuuuccuuuu                                                   20


<210>  28309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28309
acuacaaaga ccucauguaa                                                   20


<210>  28310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28310
uuguaguaga caaaagccau                                                   20


<210>  28311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28311
uggaacuccu acccucaagu                                                   20


<210>  28312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28312
cccccacgau gggcagcagc                                                   20


<210>  28313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28313
agugaaaaua cguuucucuu                                                   20


<210>  28314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28314
gaagcaucug gauaaaaaug                                                   20


<210>  28315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28315
gccacaugau ggugcccaca                                                   20


<210>  28316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28316
ccuuuauuuc uucaaccauu                                                   20


<210>  28317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28317
uuguuucugg cuauuuucaa                                                   20


<210>  28318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28318
gccaaaauau gcaucauugu                                                   20


<210>  28319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28319
gaggacaaua aaaugacaac                                                   20


<210>  28320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28320
ucugaccacu auuauuucug                                                   20


<210>  28321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28321
uuuuauuguc cucugaccac                                                   20


<210>  28322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28322
caaaaaaaua auaauaaaac                                                   20


<210>  28323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28323
gauagcccuu cguucccuga                                                   20


<210>  28324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28324
cccagcgggg cgguggggua                                                   20


<210>  28325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28325
gggaaguuga ggcugcagug                                                   20


<210>  28326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28326
ugcccuguug cccaggcuag                                                   20


<210>  28327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28327
acuuaauuaa ugcauauuuu                                                   20


<210>  28328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28328
ccaaauaaaa uaugcauuaa                                                   20


<210>  28329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28329
cuaauugcca ugagcucuac                                                   20


<210>  28330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28330
cuaccaaaaa cacaaaaaau                                                   20


<210>  28331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28331
ccaacuccug agcuuaagug                                                   20


<210>  28332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28332
cugcccugga gccucaggag                                                   20


<210>  28333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28333
ccuaggcugg agugcagugg                                                   20


<210>  28334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28334
cccugccccu uccuuccugc                                                   20


<210>  28335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28335
uccuuccccg gcgcuggguc                                                   20


<210>  28336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28336
ccgccccucc uccggccucg                                                   20


<210>  28337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28337
aggcgagggc ggggccgagg                                                   20


<210>  28338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28338
ccucggcagc caccgccccc                                                   20


<210>  28339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28339
gacuccacga gcggccgcuu                                                   20


<210>  28340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28340
gacgagggaa cccucccagc                                                   20


<210>  28341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28341
cggaaggcag cuucugcccu                                                   20


<210>  28342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28342
acacuccacg gcucugggcc                                                   20


<210>  28343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28343
acacuagaug gcucugggcc                                                   20


<210>  28344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28344
ccucucuguc uacacuagau                                                   20


<210>  28345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28345
acacuccaca gcuauggguc                                                   20


<210>  28346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28346
cuugcuggga augugucccu                                                   20


<210>  28347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28347
cugggcaggu gaccaccuuc                                                   20


<210>  28348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28348
ccugcccagg gacacauucc                                                   20


<210>  28349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28349
aucguggcca gugcuuuugg                                                   20


<210>  28350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28350
ccaaaagcac uggccacgau                                                   20


<210>  28351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28351
gggucuuuuu cuuaaaacug                                                   20


<210>  28352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28352
uuuucuuaaa acugcaaguc                                                   20


<210>  28353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28353
cagaggcauc cgcaucauug                                                   20


<210>  28354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28354
cuccucccuc ugcucugcca                                                   20


<210>  28355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28355
ccacugcccu gucgcuccuc                                                   20


<210>  28356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28356
cagggagguu gacaaagaca                                                   20


<210>  28357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28357
accucccuga gaccuccggu                                                   20


<210>  28358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28358
uugucaaccu cccugagacc                                                   20


<210>  28359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28359
agggcuggcu cccuuucugc                                                   20


<210>  28360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28360
cggggaagaa gggguggcca                                                   20


<210>  28361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28361
gggcuuuagg auuuugugug                                                   20


<210>  28362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28362
uugauuuaga aaacaucuuu                                                   20


<210>  28363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28363
aaaauuuuau acccagcuaa                                                   20


<210>  28364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28364
cuuaaaaaaa aaauugaaca                                                   20


<210>  28365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28365
cacucuuuug cccaggcugg                                                   20


<210>  28366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28366
uagcucgcug cagccccaaa                                                   20


<210>  28367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28367
ugugucuggu uggaacuuga                                                   20


<210>  28368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28368
gguuggaacu ugauuuagca                                                   20


<210>  28369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28369
auuuacggac agagcugccg                                                   20


<210>  28370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28370
guaaauugac aguucccaca                                                   20


<210>  28371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28371
aggcaggugc aguggggcaa                                                   20


<210>  28372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28372
caagggcaca gcgcuucagg                                                   20


<210>  28373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28373
uggcugcccu ccucuguaac                                                   20


<210>  28374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28374
gucccggcug cccuccucug                                                   20


<210>  28375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28375
cggcugcccu ccucuguaac                                                   20


<210>  28376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28376
guccccggcu gcccuccucu                                                   20


<210>  28377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28377
ccggcugccc uccucuguaa                                                   20


<210>  28378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28378
cacucugcac agauuuaaaa                                                   20


<210>  28379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28379
aauacaaaug gaaaggaaga                                                   20


<210>  28380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28380
cuccccaaac cucaacaucc                                                   20


<210>  28381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28381
agccucuuga ggcucucuca                                                   20


<210>  28382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28382
cacugggucc agccucuuga                                                   20


<210>  28383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28383
agcaggaggu guggccacca                                                   20


<210>  28384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28384
ccguaccgag gcucaccuug                                                   20


<210>  28385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28385
ucuaacagcg auauuagcga                                                   20


<210>  28386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28386
cuggccaaca gccagcaggg                                                   20


<210>  28387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28387
cgugggcggc uuccuugggc                                                   20


<210>  28388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28388
gggagugacg guggauucca                                                   20


<210>  28389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28389
cucccugacc ccaaacccca                                                   20


<210>  28390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28390
uccuuggaac cugugguugc                                                   20


<210>  28391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28391
ucacaacaca aucacuuacu                                                   20


<210>  28392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28392
ugcagaagag acuacacagc                                                   20


<210>  28393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28393
cuucugcaag acucuuuaaa                                                   20


<210>  28394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28394
cgggccugcu guguagucuc                                                   20


<210>  28395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28395
cauuguuccc uuggagccau                                                   20


<210>  28396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28396
uggaagcuca ucagaauguu                                                   20


<210>  28397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28397
cccccaaggg ugcggagugu                                                   20


<210>  28398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28398
cgaaagcgug aauccguagc                                                   20


<210>  28399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28399
ugagagggag cccugcggau                                                   20


<210>  28400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28400
ccagcucgga ggcccacgaa                                                   20


<210>  28401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28401
augaaaucaa cgugaaaaaa                                                   20


<210>  28402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28402
uucacauggu gauugcugaa                                                   20


<210>  28403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28403
gccgcuucga auccuguucc                                                   20


<210>  28404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28404
cccuucuuca ucacuggaac                                                   20


<210>  28405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28405
uggaggaaau gcagucuggu                                                   20


<210>  28406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28406
gguggaauuu ucaauaugau                                                   20


<210>  28407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28407
gccgcaacuc gauuugaugu                                                   20


<210>  28408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28408
aacaucaaau cgaguugcgg                                                   20


<210>  28409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28409
aaugcugaaa accgaaucau                                                   20


<210>  28410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28410
ugacgauuuu gcauuggaug                                                   20


<210>  28411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28411
ugacuuucua guccaaugcu                                                   20


<210>  28412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28412
gacagcuugc aagccauccg                                                   20


<210>  28413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28413
gacuccaggu uggagcucgu                                                   20


<210>  28414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28414
ccagcgagug gauuuucugc                                                   20


<210>  28415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28415
ugcaugaucu ucauggucac                                                   20


<210>  28416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28416
gugcucagcu gcacacaguc                                                   20


<210>  28417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28417
uggccgagua cccggccgag                                                   20


<210>  28418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28418
gggcacacgg cgcugaaggc                                                   20


<210>  28419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28419
uccgggcaca cggcgcugaa                                                   20


<210>  28420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28420
gcaugguaac caacccgaaa                                                   20


<210>  28421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28421
uucgucugca ugguaaccaa                                                   20


<210>  28422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28422
ucauucgucu gcaugguaac                                                   20


<210>  28423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28423
gcagggcgcc cuccuccucc                                                   20


<210>  28424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28424
accaugaaca cguggcagga                                                   20


<210>  28425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28425
ggguccacca ugaacacgug                                                   20


<210>  28426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28426
gccgugcacu caaacccaaa                                                   20


<210>  28427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28427
gggucggccg ugcacucaaa                                                   20


<210>  28428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28428
ggaauucccg gcguccuccc                                                   20


<210>  28429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28429
ucccuccccg uccugcaguu                                                   20


<210>  28430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28430
ugcaguucau cucuguccug                                                   20


<210>  28431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28431
uguaccgaga caugggugag                                                   20


<210>  28432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28432
cgguacagga cagagaugaa                                                   20


<210>  28433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28433
agaaaggcgc gggcccgcau                                                   20


<210>  28434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28434
ccguccagaa aggcgcgggc                                                   20


<210>  28435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28435
cuguugcugc uggugcuguu                                                   20


<210>  28436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28436
uuguggugga ccuggguggg                                                   20


<210>  28437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28437
accacaagga cccgguugcu                                                   20


<210>  28438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28438
gcucgagcuc ccacccaggu                                                   20


<210>  28439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28439
cacgcgcugc cuccggggcc                                                   20


<210>  28440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28440
agggagcacc ccagggcugg                                                   20


<210>  28441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28441
ggaccccgaa gggagccccc                                                   20


<210>  28442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28442
ggacagaagg gcccagucca                                                   20


<210>  28443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28443
gaugagcggc cucaaauggg                                                   20


<210>  28444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28444
gucugaugag cggccucaaa                                                   20


<210>  28445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28445
cagaaccugu cagucugaug                                                   20


<210>  28446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28446
ccccuuccaa gaggggcacc                                                   20


<210>  28447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28447
acgugcuccg ggaguggcag                                                   20


<210>  28448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28448
gcacugccac ucccggagca                                                   20


<210>  28449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28449
cugguguguc cgcacugcca                                                   20


<210>  28450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28450
uggucgcugg uguguccgca                                                   20


<210>  28451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28451
agcaucaacu gcggcacacu                                                   20


<210>  28452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28452
gcggggaucu ugcucauagg                                                   20


<210>  28453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28453
aggaaggccu uuggaaugca                                                   20


<210>  28454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28454
ccaucgaaau guucgaaaga                                                   20


<210>  28455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28455
uucgaacauu ucgaugggga                                                   20


<210>  28456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28456
agcaggaggc ggugcugcca                                                   20


<210>  28457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28457
uuccagaggg uucccugcac                                                   20


<210>  28458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28458
uuacaucgua aacagccgga                                                   20


<210>  28459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28459
caggauguga acaaacacua                                                   20


<210>  28460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28460
ucuuaggaug gucucaggau                                                   20


<210>  28461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28461
gaucccauag ccuccccagu                                                   20


<210>  28462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28462
ugaggcggcc acaagauggg                                                   20


<210>  28463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28463
ggacgucgcc guggacaggu                                                   20


<210>  28464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28464
ggacccaucu uguggccgcc                                                   20


<210>  28465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28465
ccguggacag gucugcagag                                                   20


<210>  28466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28466
gcuucucccu ccucugggga                                                   20


<210>  28467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28467
acaaguaacu cagcuccccu                                                   20


<210>  28468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28468
ccaguugaug gcaaccuuag                                                   20


<210>  28469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28469
aagguugcca ucaacugggg                                                   20


<210>  28470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28470
cagagcuagc uuucccagcg                                                   20


<210>  28471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28471
uaucuguugu cgugggucuu                                                   20


<210>  28472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28472
ugggucuuga uagcuuccac                                                   20


<210>  28473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28473
ugauagcuuc caccagcuua                                                   20


<210>  28474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28474
uccaaguuaa ccugugugaa                                                   20


<210>  28475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28475
ccuucacaca gguuaacuug                                                   20


<210>  28476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28476
gcuccacugu cgccuucaca                                                   20


<210>  28477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28477
ugcgggcuug acgcccucgu                                                   20


<210>  28478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28478
agcccgcagg accaacgagu                                                   20


<210>  28479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28479
ggccuucccu ugacagugcg                                                   20


<210>  28480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28480
agggaaggcc ugacgagggc                                                   20


<210>  28481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28481
ggaaccccca ucucaggacg                                                   20


<210>  28482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28482
ugagaugggg guucccgacc                                                   20


<210>  28483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28483
uccugccugc cugcguccug                                                   20


<210>  28484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28484
cgugcgauca ccacccgcug                                                   20


<210>  28485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28485
caaccuuggu ggagaacgag                                                   20


<210>  28486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28486
uuccagcagg gguugauacu                                                   20


<210>  28487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28487
aucucuuagu ggggaugucc                                                   20


<210>  28488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28488
ccugugccag ugcugucuuu                                                   20


<210>  28489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28489
uuuaguccag gccaacaguc                                                   20


<210>  28490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28490
aggccaacag ucucugcuuc                                                   20


<210>  28491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28491
cugcuucuuc ucuugcuugu                                                   20


<210>  28492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28492
cugguuggua cugugggcca                                                   20


<210>  28493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28493
aucacaggag gugcuuucag                                                   20


<210>  28494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28494
agggcccugc uguaucaggc                                                   20


<210>  28495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28495
cuguaauggc uggacguccu                                                   20


<210>  28496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28496
agccauuaca gggaccuugc                                                   20


<210>  28497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28497
uguccacugc agaaauucuu                                                   20


<210>  28498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28498
acugcagaaa uucuuagggc                                                   20


<210>  28499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28499
gaggaaagcc cuaagaauuu                                                   20


<210>  28500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28500
aucuucuugg ccaucugcug                                                   20


<210>  28501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28501
aauagagagu gggaauuuuc                                                   20


<210>  28502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28502
guuugcuagu auuuuguuga                                                   20


<210>  28503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28503
uagccagagc agucaggcaa                                                   20


<210>  28504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28504
ggcaagagga auaaauaaaa                                                   20


<210>  28505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28505
aauuaucgug guuugcugau                                                   20


<210>  28506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28506
cccaggcugg agcacagugc                                                   20


<210>  28507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28507
cuguaaccuc aaacucuugg                                                   20


<210>  28508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28508
aagaguuuga gguuacagug                                                   20


<210>  28509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28509
cuuuaaugau auuaauuauu                                                   20


<210>  28510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28510
gaagcaaucu acauauucaa                                                   20


<210>  28511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28511
gguaauguaa uaucuccagc                                                   20


<210>  28512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28512
aguuuuauac caguaacaug                                                   20


<210>  28513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28513
ggccagguaa cagaucccag                                                   20


<210>  28514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28514
acuaaccaug uccagucugg                                                   20


<210>  28515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28515
agucuggaug ggaggucaca                                                   20


<210>  28516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28516
ggaugggagg ucacaggguc                                                   20


<210>  28517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28517
cagggucacc uuuaacucca                                                   20


<210>  28518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28518
ccuuuaacuc caaggggaag                                                   20


<210>  28519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28519
gugucuuauu uaauacauuu                                                   20


<210>  28520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28520
uauuuaauac auuuauuacu                                                   20


<210>  28521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28521
aaacagauuu ucucccuuuu                                                   20


<210>  28522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28522
auuauuugaa aaucaaucau                                                   20


<210>  28523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28523
guguuugagu gagacuaucu                                                   20


<210>  28524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28524
cacucaaaca cagacuuuaa                                                   20


<210>  28525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28525
cacaaaacaa aaaauuaaug                                                   20


<210>  28526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28526
auuauuaauc uggugaaagc                                                   20


<210>  28527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28527
gaacaaucug ccacuuauag                                                   20


<210>  28528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28528
cugauguguu gggugacugg                                                   20


<210>  28529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28529
cccaacacau cagugacccg                                                   20


<210>  28530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28530
uggcucuggg auauuacugc                                                   20


<210>  28531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28531
auugcuuggg acaucauagg                                                   20


<210>  28532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28532
caagcaauug acuaggacua                                                   20


<210>  28533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28533
uuucaugugu aauauucauc                                                   20


<210>  28534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28534
caaucuaaau aauaucacag                                                   20


<210>  28535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28535
uuccuuccau gcccgcaaua                                                   20


<210>  28536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28536
gcaucuguga cguggcugcc                                                   20


<210>  28537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28537
cagaugcuga cauacacauu                                                   20


<210>  28538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28538
ucucauuggc caggaagggg                                                   20


<210>  28539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28539
ugccccccaa cccacuuccc                                                   20


<210>  28540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28540
cacacagugc cugucagggg                                                   20


<210>  28541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28541
gggggcuuac uuugggugcc                                                   20


<210>  28542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28542
ucuggcaccc aaaguaagcc                                                   20


<210>  28543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28543
guccucuggc acccaaagua                                                   20


<210>  28544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28544
cagggccagg gcuggcagug                                                   20


<210>  28545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28545
acugccagcc cuggcccugc                                                   20


<210>  28546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28546
gggcaugguu gcccuugccg                                                   20


<210>  28547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28547
gacaggaugu gcagaauucc                                                   20


<210>  28548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28548
gaccacccca accucggcac                                                   20


<210>  28549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28549
cggagggcca cacgguaggg                                                   20


<210>  28550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28550
ccucccccuu gggagguucc                                                   20


<210>  28551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28551
aaacaaguga ggcccagagg                                                   20


<210>  28552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28552
uaaagcccca gugaccucca                                                   20


<210>  28553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28553
cuggggcuuu aagacccccc                                                   20


<210>  28554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28554
uccucucugc caaggcgagg                                                   20


<210>  28555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28555
uugccaggcc gucugggagg                                                   20


<210>  28556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28556
gggagguccc cgcaggaagg                                                   20


<210>  28557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28557
ccgcaggaag ggguuccugc                                                   20


<210>  28558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28558
agccucugga gcuccauucu                                                   20


<210>  28559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28559
ccuggugagc cagccucuuc                                                   20


<210>  28560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28560
ugggcuuguc ccguaccugc                                                   20


<210>  28561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28561
cguaccugcc ugacggcucu                                                   20


<210>  28562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28562
ggcagguacg ggacaagccc                                                   20


<210>  28563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28563
cccugaucag ggcucccguu                                                   20


<210>  28564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28564
gcugagccag gaggaagccg                                                   20


<210>  28565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28565
cgaguucucg gccuccuccu                                                   20


<210>  28566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28566
cgcuggccuu ccgguaccgc                                                   20


<210>  28567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28567
aguuaugaag gagggguggc                                                   20


<210>  28568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28568
guucuugucc cuggugccuu                                                   20


<210>  28569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28569
cuggugccuu uaagccagcc                                                   20


<210>  28570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28570
ccccaacccu ccugcuggug                                                   20


<210>  28571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28571
agcccagagc caagccccgg                                                   20


<210>  28572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28572
uugcgccucu cuaggccccg                                                   20


<210>  28573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28573
uggcacacag gcacugagug                                                   20


<210>  28574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28574
acucagugcc ugugugccau                                                   20


<210>  28575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28575
uggguggcgu cacggcacgu                                                   20


<210>  28576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28576
cggcacgugg gcacugagug                                                   20


<210>  28577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28577
cuuacagggc augaugcuac                                                   20


<210>  28578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28578
augaaaccaa cuucacaaac                                                   20


<210>  28579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28579
uaguaacagc gucaaugaaa                                                   20


<210>  28580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28580
gacauguugg gaucuguucu                                                   20


<210>  28581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28581
gacauuacag ucuuaguaac                                                   20


<210>  28582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28582
uccuuuucau gugaaaagaa                                                   20


<210>  28583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28583
ccuaguuugg gcggaguggg                                                   20


<210>  28584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28584
cggcucccac uccgcccaaa                                                   20


<210>  28585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28585
agagucacgg cucccacucc                                                   20


<210>  28586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28586
ggcuuucccg ggacaccucc                                                   20


<210>  28587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28587
cgggaaagcc agacggccca                                                   20


<210>  28588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28588
gccccuugug uuccucagau                                                   20


<210>  28589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28589
aucugaggaa cacaaggggc                                                   20


<210>  28590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28590
ugaggcuuaa uuaacucaug                                                   20


<210>  28591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28591
cucucucuuu ucuuucaguc                                                   20


<210>  28592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28592
gcaacugugu cugauggcgg                                                   20


<210>  28593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28593
gauggcggua agucacaauu                                                   20


<210>  28594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28594
caauuucuga uguauauauu                                                   20


<210>  28595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28595
uuccugaggg caucaaaugg                                                   20


<210>  28596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28596
ccuugugggc ggguucuagg                                                   20


<210>  28597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28597
cagaaagcgc ccccagaauu                                                   20


<210>  28598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28598
gaggagugca cccacccgcc                                                   20


<210>  28599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28599
gacaaguuaa aacguguuuu                                                   20


<210>  28600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28600
gacacaggca ggcggguggg                                                   20


<210>  28601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28601
cacccaaauu uccugaauug                                                   20


<210>  28602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28602
auuauacuuu ucuugagaaa                                                   20


<210>  28603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28603
augaaaagaa ucccugugca                                                   20


<210>  28604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28604
uauuucacug aagauuucuc                                                   20


<210>  28605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28605
uccuuaucau uuugguucaa                                                   20


<210>  28606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28606
ggaguguuag aagaaaagag                                                   20


<210>  28607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28607
gcaggcucuc ggguuucauc                                                   20


<210>  28608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28608
ccucacgcuu uuguccccac                                                   20


<210>  28609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28609
ccacuucugu cccugagagc                                                   20


<210>  28610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28610
cugagagcug gaauaggugc                                                   20


<210>  28611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28611
uucucucacu uucugugguc                                                   20


<210>  28612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28612
ugcagcugcu ggccucaguc                                                   20


<210>  28613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28613
ucggccucgg aaagggcugc                                                   20


<210>  28614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28614
ccagguaggc agacagagcu                                                   20


<210>  28615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28615
gccuaccugg ggacagcagc                                                   20


<210>  28616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28616
uccuggccuu ccuacagagu                                                   20


<210>  28617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28617
gcccaccugg gguccuccug                                                   20


<210>  28618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28618
cggcuucagg ugccagugcg                                                   20


<210>  28619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28619
ggaucccucu ggucucggcu                                                   20


<210>  28620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28620
uuuaaucagu cuuaaggugg                                                   20


<210>  28621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28621
uaagguggag ggaggauaaa                                                   20


<210>  28622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28622
uguuucuuuu cauuaaggaa                                                   20


<210>  28623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28623
cuuuauccug gauuugguuc                                                   20


<210>  28624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28624
ucugccagaa aggagaagug                                                   20


<210>  28625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28625
gcaauagaug caggaaccca                                                   20


<210>  28626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28626
auuuuacagu uguuuaaaaa                                                   20


<210>  28627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28627
cuagcuccuc gccgugcugg                                                   20


<210>  28628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28628
cucugaggaa guguguccug                                                   20


<210>  28629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28629
uggcuccucg ccacgcuggc                                                   20


<210>  28630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28630
cucugaggaa guguauccug                                                   20


<210>  28631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28631
gacccugggg ccacugggac                                                   20


<210>  28632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28632
gacacuggga aaagaaggag                                                   20


<210>  28633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28633
caguggcccc agggucugac                                                   20


<210>  28634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28634
cuccauggag agccccaguc                                                   20


<210>  28635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28635
cagaggagga gacgggaggg                                                   20


<210>  28636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28636
ccuccucugu gacuggggcu                                                   20


<210>  28637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28637
ccuccucccu cccgucuccu                                                   20


<210>  28638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28638
ccuccucccu cccgucuccu                                                   20


<210>  28639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28639
ccuccucccu cccgucuccu                                                   20


<210>  28640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28640
ccucccuccc gucuccuccu                                                   20


<210>  28641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28641
ucagcacacc cugaauuuca                                                   20


<210>  28642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28642
cauucugccg uuguuagaug                                                   20


<210>  28643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28643
gcaggugaga uggccagacu                                                   20


<210>  28644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28644
ggccaucuca ccugcagacu                                                   20


<210>  28645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28645
uggagagucc cccgcuccag                                                   20


<210>  28646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28646
cccgcuccag cccuggaccc                                                   20


<210>  28647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28647
agggcuggag cgggggacuc                                                   20


<210>  28648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28648
cugccgugga gggcagggug                                                   20


<210>  28649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28649
gggugggggg guggucccag                                                   20


<210>  28650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28650
cagggaaacu cuggcugugu                                                   20


<210>  28651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28651
gugggagacu cagugcacug                                                   20


<210>  28652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28652
cccacugacc acagccuaua                                                   20


<210>  28653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28653
cuccuuggaa cucggggagc                                                   20


<210>  28654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28654
cugccugguc auccugucua                                                   20


<210>  28655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28655
uccugucuag uuuuggugau                                                   20


<210>  28656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28656
aguuuuggug auuaauagau                                                   20


<210>  28657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28657
cagaaugaaa ccguggcaug                                                   20


<210>  28658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28658
aacuuccuua aaaccgagcc                                                   20


<210>  28659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28659
aguuggagug uguuuuuuca                                                   20


<210>  28660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28660
cuggggggca cggcagggcu                                                   20


<210>  28661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28661
gccuuguggg aaguuauuca                                                   20


<210>  28662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28662
gaauaacuuc ccacaaggca                                                   20


<210>  28663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28663
agcuggaggg agauggggcg                                                   20


<210>  28664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28664
ggcucugcac agagcuggag                                                   20


<210>  28665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28665
agcucugugc caagaggccu                                                   20


<210>  28666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28666
cagcgggaac auccaccugu                                                   20


<210>  28667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28667
ggguguggag acuaucgggg                                                   20


<210>  28668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28668
ccacaccccg acuucagaag                                                   20


<210>  28669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28669
gugccagcag gaaagccggg                                                   20


<210>  28670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28670
cccaaagcca gagccgcaca                                                   20


<210>  28671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28671
acaugacacc ccacauacau                                                   20


<210>  28672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28672
uguggaccug ccaccguccc                                                   20


<210>  28673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28673
uguauguggg gugucaugug                                                   20


<210>  28674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28674
ccagggugag gcugcgagaa                                                   20


<210>  28675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28675
ggggucccca gggugaggcu                                                   20


<210>  28676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28676
caguccucca uccccauguc                                                   20


<210>  28677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28677
uccaucccca uguccuccuc                                                   20


<210>  28678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28678
uccucaugcc uugugccuca                                                   20


<210>  28679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28679
gggcagagcu gaggcacaag                                                   20


<210>  28680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28680
acucagcugc cccccuacuc                                                   20


<210>  28681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28681
uccaugcaga ccucagucuu                                                   20


<210>  28682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28682
gcauggagga cgaguagggg                                                   20


<210>  28683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28683
uggcccuguc ucugcagcca                                                   20


<210>  28684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28684
cugcagccau ccucccgcuc                                                   20


<210>  28685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28685
agugcagggg cugggcagau                                                   20


<210>  28686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28686
cacccugguc uccaauggug                                                   20


<210>  28687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28687
ccaauggugc cucaggcaca                                                   20


<210>  28688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28688
ggaagggaag agggaaaccg                                                   20


<210>  28689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28689
auuuccugcc cgugcuaggg                                                   20


<210>  28690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28690
ccccagcugg ugugaccucc                                                   20


<210>  28691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28691
caccagcugg ggggacaaaa                                                   20


<210>  28692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28692
gaguuguccc ggcacccggc                                                   20


<210>  28693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28693
cggcacccgg cacagcggcu                                                   20


<210>  28694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28694
guugagugaa ugaucgggug                                                   20


<210>  28695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28695
gcugaacacc cgaucauuca                                                   20


<210>  28696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28696
gggcgaggcu ugggcgggga                                                   20


<210>  28697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28697
ccgcccaagc cucgcccuga                                                   20


<210>  28698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28698
ugaaaccuuc ucaaaaagca                                                   20


<210>  28699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28699
cacaggaguu ucugcuucug                                                   20


<210>  28700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28700
accccgcaac accagucaca                                                   20


<210>  28701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28701
gagcuccaaa ggcccgcgug                                                   20


<210>  28702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28702
gcuguggagc ugcaggugga                                                   20


<210>  28703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28703
cuuucucucu ccuagccuug                                                   20


<210>  28704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28704
ucaucucgcc gguccuuguu                                                   20


<210>  28705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28705
uuguuagcga acaggcacug                                                   20


<210>  28706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28706
caaacggcug ccugaugggg                                                   20


<210>  28707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28707
cccaaguuaa uccggcaauu                                                   20


<210>  28708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28708
gauauuaaua uuguuaugcc                                                   20


<210>  28709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28709
uuuuuguucu uuuuauugcu                                                   20


<210>  28710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28710
guuagauuua auuugcucau                                                   20


<210>  28711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28711
ggagcuauuc ucuguaugcu                                                   20


<210>  28712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28712
aucauaaaau gauaacaaaa                                                   20


<210>  28713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28713
aggaagaaau uaaaauggga                                                   20


<210>  28714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28714
caaauuccug ggcccaagug                                                   20


<210>  28715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28715
aggcuggucu caaauuccug                                                   20


<210>  28716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28716
ucuuccucuu uuucuuuuuu                                                   20


<210>  28717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28717
uucauucuug auguuaucuu                                                   20


<210>  28718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28718
uaaguacagu uagagacuaa                                                   20


<210>  28719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28719
cuaacuguac uuaggaccug                                                   20


<210>  28720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28720
uauaguguua cuucuuaguc                                                   20


<210>  28721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28721
gguuaaucaa auguacagua                                                   20


<210>  28722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28722
aagaucaaaa cccccauagg                                                   20


<210>  28723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28723
gcuuaggcua aguaauauug                                                   20


<210>  28724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28724
uuucccucgg ccacaaggcc                                                   20


<210>  28725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28725
uggcucucag ccauacuguu                                                   20


<210>  28726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28726
cugugaaguc cgagcacggu                                                   20


<210>  28727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28727
gagcacgguu uuuacugcgg                                                   20


<210>  28728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28728
ugcccaguga ggaaggagcg                                                   20


<210>  28729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28729
gauccaaaca gugugacucu                                                   20


<210>  28730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28730
cacuguuugg aucugacuca                                                   20


<210>  28731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28731
acagugugcc gguucacggc                                                   20


<210>  28732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28732
gcucuauggc aagcuguauu                                                   20


<210>  28733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28733
gcaccuguga aucgugagaa                                                   20


<210>  28734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28734
cuugcugcgu aaaaguccag                                                   20


<210>  28735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28735
agggcuuugc agagccucuc                                                   20


<210>  28736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28736
gcaaggagaa gcagucucca                                                   20


<210>  28737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28737
ccagaggugg cccccugagc                                                   20


<210>  28738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28738
ggccccuucc caggggugga                                                   20


<210>  28739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28739
acuggcccag ggagguaggc                                                   20


<210>  28740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28740
cauguccacu ggcccaggga                                                   20


<210>  28741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28741
ccaugcuggu cccaugucca                                                   20


<210>  28742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28742
uaaaccgggc uuccaaaaau                                                   20


<210>  28743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28743
uuuguccuaa accgggcuuc                                                   20


<210>  28744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28744
ucacaguccc agcaaauacc                                                   20


<210>  28745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28745
cagcaaauac cauuuauaug                                                   20


<210>  28746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28746
uguguuaccu cuuuuuggcu                                                   20


<210>  28747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28747
caaauccuuu augcuuuuac                                                   20


<210>  28748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28748
ucuggccuca guccugcugg                                                   20


<210>  28749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28749
ugcuggguag ggugcccuuu                                                   20


<210>  28750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28750
ucucuauccc uggacucuuu                                                   20


<210>  28751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28751
agggauagag aggacgaaag                                                   20


<210>  28752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28752
ccaggacugu gucuucaguu                                                   20


<210>  28753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28753
uggggaccug ugcuuccacu                                                   20


<210>  28754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28754
ucaguuuucu gugugggugg                                                   20


<210>  28755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28755
uaaacccuuc ccucaagcca                                                   20


<210>  28756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28756
uccucaugag gucagcauuu                                                   20


<210>  28757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28757
gcauuugggg ccccugggcu                                                   20


<210>  28758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28758
ucugcguugg guggcguccu                                                   20


<210>  28759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28759
ucugcguugg gugguguccu                                                   20


<210>  28760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28760
ucuggugggg ccaagccaca                                                   20


<210>  28761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28761
gaacuuccug uguggccacu                                                   20


<210>  28762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28762
uuacaaagua uaaauauuuu                                                   20


<210>  28763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28763
guuucacaaa ggaauuaacc                                                   20


<210>  28764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28764
guuaggguug aucuuugaaa                                                   20


<210>  28765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28765
uuucuuggag cauccugagg                                                   20


<210>  28766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28766
gaugugaccu caccaacuac                                                   20


<210>  28767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28767
caucugacca cagggagccc                                                   20


<210>  28768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28768
uaguugguag cucuaagccu                                                   20


<210>  28769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28769
cucugaauuu uuaggauucu                                                   20


<210>  28770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28770
cuugucacuc ugaauuuuua                                                   20


<210>  28771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28771
uugcacaucg ccuaacacuu                                                   20


<210>  28772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28772
gugugggaag uguuaggcga                                                   20


<210>  28773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28773
uucuggagag ugaaaugcca                                                   20


<210>  28774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28774
cuucagacgu agagaguuug                                                   20


<210>  28775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28775
gaagugacac caaguccuuc                                                   20


<210>  28776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28776
guacuagaaa cgugugauuu                                                   20


<210>  28777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28777
uuccuggagu caguacuaga                                                   20


<210>  28778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28778
gugagaccug ccaggcgugg                                                   20


<210>  28779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28779
cacggacccc ucgagauaua                                                   20


<210>  28780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28780
ggcugugggg gccagacuca                                                   20


<210>  28781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28781
ggcccccaca gccagaccuc                                                   20


<210>  28782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28782
gcccagaaag ugcugcuggg                                                   20


<210>  28783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28783
cgguaucccc agcagcacuu                                                   20


<210>  28784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28784
gggcccagca uagucacuga                                                   20


<210>  28785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28785
cugaugucag cccaggcagg                                                   20


<210>  28786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28786
gcccaggcag gucauggaau                                                   20


<210>  28787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28787
uggaauguuu uggaccucag                                                   20


<210>  28788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28788
aaaacauucc augaccugcc                                                   20


<210>  28789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28789
aucagcccau uuuacagaug                                                   20


<210>  28790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28790
ggcaagaaca gguaggguag                                                   20


<210>  28791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28791
uccuuccucc gcaagccagc                                                   20


<210>  28792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28792
ccacccaaau cucaucuuga                                                   20


<210>  28793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28793
aacuguauca ggcauccuau                                                   20


<210>  28794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28794
cacccguuug ugcauccaca                                                   20


<210>  28795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28795
gcugagugug gcaagcacug                                                   20


<210>  28796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28796
ugcaucucca aguggccugg                                                   20


<210>  28797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28797
ccaucauccc cuuggaauca                                                   20


<210>  28798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28798
augagcaucu uucaaaauga                                                   20


<210>  28799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28799
cagcuuccuc uucuaccuug                                                   20


<210>  28800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28800
gggacagguc ccuuggccac                                                   20


<210>  28801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28801
cugacuagcc acaccaccuu                                                   20


<210>  28802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28802
cuuggccaca gagccacugg                                                   20


<210>  28803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28803
uggcacauug ccacccgcca                                                   20


<210>  28804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28804
ggcagagaug gcaguguccc                                                   20


<210>  28805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28805
cuggccacag uguccagcag                                                   20


<210>  28806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28806
agcagcagca uggcagccgc                                                   20


<210>  28807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28807
gacaggggug cugcugugac                                                   20


<210>  28808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28808
gaccacagag cccugcugcg                                                   20


<210>  28809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28809
cagcagcacc ccugucugac                                                   20


<210>  28810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28810
caggucacag cagcaccccu                                                   20


<210>  28811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28811
ccaccuucaa aggagcccac                                                   20


<210>  28812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28812
uccucuuuca ggauguggcu                                                   20


<210>  28813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28813
ccaagaacca aggggaaggc                                                   20


<210>  28814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28814
cagcgcucuc ggccagucug                                                   20


<210>  28815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28815
gggaguggca gccaggccac                                                   20


<210>  28816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28816
acccuccggc auccugugug                                                   20


<210>  28817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28817
guggcuacag ccccaacggc                                                   20


<210>  28818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28818
ugggccagcc ccuugggggc                                                   20


<210>  28819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28819
cagagcccca uucaugcucc                                                   20


<210>  28820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28820
ccugugcagc caccagccgc                                                   20


<210>  28821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28821
cccgccuugc augaggcccu                                                   20


<210>  28822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28822
gggccucaug caaggcgggg                                                   20


<210>  28823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28823
ugucagggcc ucaugcaagg                                                   20


<210>  28824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28824
ccggugggcc acaaggguug                                                   20


<210>  28825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28825
cuuggaucac aggggcagug                                                   20


<210>  28826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28826
gccgaugugg cucaguccug                                                   20


<210>  28827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28827
uggcugugag gccucacgcu                                                   20


<210>  28828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28828
gccucgcacu gaggagcaaa                                                   20


<210>  28829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28829
ggaugggaug aaaugaagac                                                   20


<210>  28830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28830
ucauuucauc ccauccagac                                                   20


<210>  28831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28831
ccucccuaac gggacacugu                                                   20


<210>  28832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28832
cguuagggag gagacgucuu                                                   20


<210>  28833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28833
accccuuccu ucuucucccc                                                   20


<210>  28834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28834
gccccgugag gauggggucu                                                   20


<210>  28835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28835
aggguagggc auguggacgg                                                   20


<210>  28836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28836
acaugcccua cccuagaccc                                                   20


<210>  28837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28837
aggugcuuau cuucuagggu                                                   20


<210>  28838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28838
ccaaccccag ggugguggag                                                   20


<210>  28839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28839
cucggauggg gcugacaccc                                                   20


<210>  28840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28840
gccccauccg agagacggcc                                                   20


<210>  28841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28841
gugccuuggg ugucagcccc                                                   20


<210>  28842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28842
cccaaagcac auggccucuc                                                   20


<210>  28843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28843
cauccagguu cuucugcaga                                                   20


<210>  28844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28844
ccaagcucug gccugggcau                                                   20


<210>  28845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28845
agcugucccc aagcucuggc                                                   20


<210>  28846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28846
aggaggggga guccagaagc                                                   20


<210>  28847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28847
agaagcgcaa aguccaccca                                                   20


<210>  28848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28848
acccagcugg gagggcugcu                                                   20


<210>  28849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28849
uuuacaaagc aggcagcucc                                                   20


<210>  28850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28850
ccaccucuuc ugcccccauc                                                   20


<210>  28851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28851
uggacccgcc caccugcacu                                                   20


<210>  28852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28852
aggacccaca gugccgccuc                                                   20


<210>  28853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28853
cugcaggcuu uuaaugggaa                                                   20


<210>  28854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28854
cuuccuccau uucuguuccc                                                   20


<210>  28855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28855
gggagccccu ggcagccucu                                                   20


<210>  28856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28856
ccucagugug ggggaagccu                                                   20


<210>  28857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28857
guuguccggg ugucuaguga                                                   20


<210>  28858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28858
gggugucuag ugaccccugg                                                   20


<210>  28859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28859
agugaccccu gggguagggg                                                   20


<210>  28860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28860
cuagacaccc ggacaacaga                                                   20


<210>  28861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28861
gggaagccgg auuguuugaa                                                   20


<210>  28862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28862
ucaaacaauc cggcuuccca                                                   20


<210>  28863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28863
gcuagguggu ugucucugcu                                                   20


<210>  28864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28864
cugcuuuuug aaaaagaagu                                                   20


<210>  28865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28865
ccgcccgacc cccgccccgc                                                   20


<210>  28866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28866
ggcggggacu ucuuuuucaa                                                   20


<210>  28867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28867
gagcgucuga gcccagaugg                                                   20


<210>  28868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28868
gagcccagau ggugcgcuug                                                   20


<210>  28869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28869
cgcggcggcc acuggagccg                                                   20


<210>  28870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28870
ccggugucgc cgcccugccc                                                   20


<210>  28871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28871
ccgcccugcc cgcgggcccg                                                   20


<210>  28872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28872
cuuucaaaau agcucgcagg                                                   20


<210>  28873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28873
ugguuccgcg ccgccgcgcu                                                   20


<210>  28874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28874
ucuucuguca ugguuccgcg                                                   20


<210>  28875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28875
agcugcggga cggcaagaag                                                   20


<210>  28876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28876
cgcagcuuga ccuggcccuc                                                   20


<210>  28877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28877
gggcgcgucg ggggcgcggg                                                   20


<210>  28878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28878
ggggcgcggg gggggggggc                                                   20


<210>  28879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28879
ccgcagugga agaguaggug                                                   20


<210>  28880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28880
cccguggcag gugagcgggg                                                   20


<210>  28881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28881
cccgcccgcc ccgcucaccu                                                   20


<210>  28882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28882
cuacccccgc gccccccguc                                                   20


<210>  28883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28883
ccccgccggg aaacccgaga                                                   20


<210>  28884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28884
gcacggggcu cucggguuuc                                                   20


<210>  28885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28885
ggguccgcac ggggcucucg                                                   20


<210>  28886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28886
agggccccca ccugcgcucc                                                   20


<210>  28887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28887
gcccugcugg aaagaggguu                                                   20


<210>  28888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28888
ccuccgccua cagggccacc                                                   20


<210>  28889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28889
gcgcuaaccc acgcagcacc                                                   20


<210>  28890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28890
agggucagcg cuaacccacg                                                   20


<210>  28891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28891
gccugggagg gguccagggu                                                   20


<210>  28892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28892
cucugcccug cccuaccgca                                                   20


<210>  28893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28893
ucugggagga ggcagggguc                                                   20


<210>  28894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28894
ccccccaguc cccgcccuga                                                   20


<210>  28895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28895
ccgcccugag ccagcacccc                                                   20


<210>  28896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28896
gcauggagcc cccaggucug                                                   20


<210>  28897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28897
ggcagcccag gccgccugca                                                   20


<210>  28898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28898
ucuggagcag cugcaggccc                                                   20


<210>  28899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28899
gggugggaug cucggccugu                                                   20


<210>  28900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28900
uggagggugc ucuggcagcc                                                   20


<210>  28901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28901
gugacuccca gggagggugu                                                   20


<210>  28902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28902
cagacacccg uccuggaggg                                                   20


<210>  28903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28903
ccucugcagg gccucaggug                                                   20


<210>  28904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28904
uggaggaaag cacuuccugc                                                   20


<210>  28905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28905
aggcccugca aggggaggcg                                                   20


<210>  28906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28906
cuucuccacu cagcccuccg                                                   20


<210>  28907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28907
gggcacggag ggcugagugg                                                   20


<210>  28908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28908
gugcccccac agcuccaggc                                                   20


<210>  28909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28909
uuguccuccg gggcugcagg                                                   20


<210>  28910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28910
uccggggcug caggggaccu                                                   20


<210>  28911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28911
ccugcagccc cggaggacaa                                                   20


<210>  28912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28912
gggcagagug agaggcccug                                                   20


<210>  28913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28913
uccgccccag ccuggcaggg                                                   20


<210>  28914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28914
gcuguggcug ggucggggcc                                                   20


<210>  28915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28915
gggccguggu ggggcaggug                                                   20


<210>  28916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28916
gcaccggcuc cagcccagca                                                   20


<210>  28917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28917
cgggugccuu ccugggaugc                                                   20


<210>  28918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28918
ggggagaagu cuuugucccu                                                   20


<210>  28919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28919
uugucccugu uggagggauu                                                   20


<210>  28920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28920
cuguuggagg gauuuucuuu                                                   20


<210>  28921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28921
gaugcagaaa gaaaaucccu                                                   20


<210>  28922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28922
caggaggcag ggccugccag                                                   20


<210>  28923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28923
cuccacucag gcacucaccg                                                   20


<210>  28924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28924
cccagguggg acaaucugug                                                   20


<210>  28925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28925
caccuggggg acccauugca                                                   20


<210>  28926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28926
guaggugaac augguggcuc                                                   20


<210>  28927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28927
gcuggguuau cccguauccu                                                   20


<210>  28928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28928
cuagcaccca cugacucacu                                                   20


<210>  28929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28929
gugggugcua gggacaccug                                                   20


<210>  28930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28930
caggccagug agucaguggg                                                   20


<210>  28931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28931
aaagcaaugg gucccaggcc                                                   20


<210>  28932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28932
cuccagcagc ccaggguuga                                                   20


<210>  28933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28933
guuucaaccc ugggcugcug                                                   20


<210>  28934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28934
gucagaugag gggaugggac                                                   20


<210>  28935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28935
gaugagggga ugggacagag                                                   20


<210>  28936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28936
cauccccuca ucugaccgac                                                   20


<210>  28937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28937
ggguggggag gugggcguga                                                   20


<210>  28938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28938
ccagcgcuga gcgggaaggc                                                   20


<210>  28939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28939
gcuccuccag ggcuggggcc                                                   20


<210>  28940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28940
gugcugucug cuccuccagg                                                   20


<210>  28941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28941
cgucugcuuc cuuguaagac                                                   20


<210>  28942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28942
gcuuccuugu aagacaggca                                                   20


<210>  28943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28943
uacaaggaag cagacgggac                                                   20


<210>  28944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28944
uucuguuaug acaagguuua                                                   20


<210>  28945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28945
uaacagaaag acgugcucac                                                   20


<210>  28946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28946
acuggccaug ccaggcgcug                                                   20


<210>  28947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28947
ggccgucugc cucggugugg                                                   20


<210>  28948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28948
gccucggugu gggacugcag                                                   20


<210>  28949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28949
cacaccgagg cagacggccc                                                   20


<210>  28950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28950
cacugcaggg cacccugcag                                                   20


<210>  28951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28951
ccaccgcguc cucacugcgg                                                   20


<210>  28952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28952
ucacugcgga augcgugucu                                                   20


<210>  28953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28953
gcguccccuc ucugggcagg                                                   20


<210>  28954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28954
ccucucuggg cagggccccg                                                   20


<210>  28955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28955
guguccaguu guggcccagg                                                   20


<210>  28956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28956
aguuguggcc caggacucac                                                   20


<210>  28957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28957
ugggccacaa cuggacacag                                                   20


<210>  28958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28958
agaacacuuu ccucaccacc                                                   20


<210>  28959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28959
ggccuggggc cacacucucc                                                   20


<210>  28960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28960
uggagcuggc agggucuugg                                                   20


<210>  28961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28961
uggagucacc augguggggg                                                   20


<210>  28962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28962
ccaugguggg gggaagcuga                                                   20


<210>  28963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28963
ugggccagau cccucggguu                                                   20


<210>  28964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28964
augucuuggg ccagaucccu                                                   20


<210>  28965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28965
ccccuauccu ugcucucggu                                                   20


<210>  28966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28966
caccgagagc aaggauaggg                                                   20


<210>  28967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28967
cuccugcagg ccgggcucag                                                   20


<210>  28968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28968
ccgugggguc ccuccugcag                                                   20


<210>  28969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28969
uggggcccug cccuccacag                                                   20


<210>  28970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28970
acccccagcc ccucguuagc                                                   20


<210>  28971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28971
gcccuuccug agcagagccu                                                   20


<210>  28972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28972
ggcuccugcc ccaacggacu                                                   20


<210>  28973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28973
guuggggcag gagccagacg                                                   20


<210>  28974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28974
gccccagucc guuggggcag                                                   20


<210>  28975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28975
ucagcccgga gcugggaugu                                                   20


<210>  28976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28976
cccuguucuu gauguuucua                                                   20


<210>  28977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28977
ggacagggaa ucagagagcu                                                   20


<210>  28978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28978
ugacgcgggg gcugagggaa                                                   20


<210>  28979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28979
cugcucccac auguggagcu                                                   20


<210>  28980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28980
caggucacug cucccacaug                                                   20


<210>  28981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28981
ucgucuacuc acagggcucu                                                   20


<210>  28982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28982
acucacaggg cucuugaggg                                                   20


<210>  28983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28983
ugggcugccc uuggugaugu                                                   20


<210>  28984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence GTCN PAM

<400>  28984
guggucuggg gggcccaccu                                                   20


<210>  28985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  28985
aauuauuuuu agggauauca                                                   20


<210>  28986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  28986
caaaaacuga aauccaaaga                                                   20


<210>  28987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  28987
guuuuugaga auguuuccaa                                                   20


<210>  28988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  28988
uuggauuuca guuuuugaga                                                   20


<210>  28989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  28989
uggggagacu gggcuagcac                                                   20


<210>  28990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  28990
ggugggggag agccaagcgc                                                   20


<210>  28991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  28991
uuguccaugg aggggccccc                                                   20


<210>  28992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  28992
ugcuggaggg aggcaggggg                                                   20


<210>  28993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  28993
cauuguuuuc cugcuggagg                                                   20


<210>  28994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  28994
auuucucauu guuuuccugc                                                   20


<210>  28995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  28995
aaaugcuuac uguaagaagg                                                   20


<210>  28996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  28996
uacaguaagc auuuugaagc                                                   20


<210>  28997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  28997
uucuuacagu aagcauuuug                                                   20


<210>  28998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  28998
auucauccua uccaacuauu                                                   20


<210>  28999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  28999
uccuauccaa cuauucuaca                                                   20


<210>  29000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29000
acauuaauua ccauaacaua                                                   20


<210>  29001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29001
auucuacuug ugcuuaaucu                                                   20


<210>  29002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29002
acuugugcuu aaucuauuca                                                   20


<210>  29003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29003
gaucagucaa aaaauaucca                                                   20


<210>  29004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29004
cuuuugucuu ccuccuucaa                                                   20


<210>  29005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29005
uccuucaaac acuugacuug                                                   20


<210>  29006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29006
aacacuugac uugcccauca                                                   20


<210>  29007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29007
guuggauugc aaaaaaaacu                                                   20


<210>  29008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29008
ccaaauggga cucauguaaa                                                   20


<210>  29009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29009
ugcaggaaag gagacuuugc                                                   20


<210>  29010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29010
ugcaggaagg cacuggacug                                                   20


<210>  29011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29011
uccuggcugu agagguucga                                                   20


<210>  29012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29012
agcaagguga cuugucuuga                                                   20


<210>  29013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29013
caaaugaccc ucacaccuca                                                   20


<210>  29014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29014
auccguuaag gcacugaggu                                                   20


<210>  29015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29015
ccgcugccac ccgagcccug                                                   20


<210>  29016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29016
ccaugucgga cuggccccca                                                   20


<210>  29017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29017
uccucagggg gaccuguaac                                                   20


<210>  29018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29018
cagcaaccaa guacccgcca                                                   20


<210>  29019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29019
gguagguggc ggguacuugg                                                   20


<210>  29020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29020
cucucagaau ggccuggcug                                                   20


<210>  29021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29021
gagagugaaa gcgucucagu                                                   20


<210>  29022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29022
uccagccagg ccauucugag                                                   20


<210>  29023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29023
aguuccucca gccaggccau                                                   20


<210>  29024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29024
uggagucuca gaggccauca                                                   20


<210>  29025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29025
ugucaguguu ucuuggaguc                                                   20


<210>  29026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29026
guggaagucc ccgccugcuu                                                   20


<210>  29027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29027
acagaaccaa cguuuagcua                                                   20


<210>  29028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29028
gccauuauug acugggguca                                                   20


<210>  29029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29029
agaaggcagg ucucagcauc                                                   20


<210>  29030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29030
ggaauuguug ggagcaugug                                                   20


<210>  29031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29031
cuagugucag guggggaugc                                                   20


<210>  29032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29032
cgucccuccc acaccugugc                                                   20


<210>  29033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29033
cagccaggcc cuggagcucc                                                   20


<210>  29034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29034
gugguugccg gucauguguc                                                   20


<210>  29035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29035
ugucuucagu gguugccggu                                                   20


<210>  29036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29036
ccaguguuuu cuugucuuca                                                   20


<210>  29037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29037
gugcuucccc aguguuuucu                                                   20


<210>  29038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29038
cagcauuuau uuuucuucaa                                                   20


<210>  29039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29039
ucaaauugga aucagcucac                                                   20


<210>  29040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29040
aauuggaauc agcucaccau                                                   20


<210>  29041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29041
aauuugaaga aaaauaaaug                                                   20


<210>  29042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29042
ccuuugcacc cggcacaccc                                                   20


<210>  29043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29043
cacauuuaga gcaagcacau                                                   20


<210>  29044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29044
gggaauucuu gguggcugaa                                                   20


<210>  29045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29045
cagaauaccg gaugugcuug                                                   20


<210>  29046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29046
ugguggcuga aaauggccac                                                   20


<210>  29047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29047
gccaccaaga auucccagaa                                                   20


<210>  29048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29048
guggccauuu ucagccacca                                                   20


<210>  29049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29049
accuuaagag gagagauggc                                                   20


<210>  29050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29050
cucccccguc ugcccugccu                                                   20


<210>  29051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29051
cguaauugau auuuggacuc                                                   20


<210>  29052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29052
guuaaauggg cgagucagag                                                   20


<210>  29053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29053
aguaagcgcc cagcccugcc                                                   20


<210>  29054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29054
cuggcagggc agggcugggc                                                   20


<210>  29055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29055
guuugugguu gggggagugu                                                   20


<210>  29056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29056
ugcgcuuugc ugagguuucu                                                   20


<210>  29057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29057
uaagaggcca gggaguaggu                                                   20


<210>  29058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29058
acaaagccac cucaagagca                                                   20


<210>  29059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29059
acaucagcac ucaggcugug                                                   20


<210>  29060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29060
uuuuuccaca ucagcacuca                                                   20


<210>  29061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29061
gggaggggug gcaugaccug                                                   20


<210>  29062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29062
gaauucagag aaccacacac                                                   20


<210>  29063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29063
gaaggcucug gggcuccccc                                                   20


<210>  29064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29064
gagaaccaca cacagcugag                                                   20


<210>  29065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29065
cugaauucag aaggcucugg                                                   20


<210>  29066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29066
ugagcccccu ccgugccagg                                                   20


<210>  29067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29067
ggaugcugca caggcugagc                                                   20


<210>  29068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29068
agcagcucac cucagagaga                                                   20


<210>  29069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29069
cucugaggug agcugcugga                                                   20


<210>  29070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29070
gcugauaaac uccaagugcc                                                   20


<210>  29071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29071
uuuucagcug auaaacucca                                                   20


<210>  29072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29072
ucaguagccu ggcuagaagu                                                   20


<210>  29073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29073
agccaggcua cugaugaauu                                                   20


<210>  29074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29074
agggacuugg gauuugagug                                                   20


<210>  29075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29075
uuucccaggu gacgcaaagc                                                   20


<210>  29076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29076
caggugacgc aaagcaggga                                                   20


<210>  29077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29077
cugcuuugcg ucaccuggga                                                   20


<210>  29078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29078
aagccccagc uguauacuuc                                                   20


<210>  29079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29079
gggggaucuc ugucaucgcc                                                   20


<210>  29080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29080
ggaccaaaca gauauaucca                                                   20


<210>  29081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29081
uuuccagggu gccgccccuc                                                   20


<210>  29082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29082
agggugccgc cccucucaac                                                   20


<210>  29083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29083
agggcccaug accaaguggg                                                   20


<210>  29084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29084
agcccacuug gucaugggcc                                                   20


<210>  29085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29085
ggguuccagc ccacuugguc                                                   20


<210>  29086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29086
gcucuuguua acccagccuc                                                   20


<210>  29087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29087
ugcccuucgg cucuuguuaa                                                   20


<210>  29088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29088
cacaaaacau gccagugggg                                                   20


<210>  29089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29089
uucauaaagc acacacaccc                                                   20


<210>  29090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29090
uaaagcacac acacccagca                                                   20


<210>  29091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29091
cuuggcaaag gccaugucau                                                   20


<210>  29092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29092
aggcccagau uagcgaugac                                                   20


<210>  29093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29093
uguaaacauu ccaggcccag                                                   20


<210>  29094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29094
uuauaaaucu gccuuacuga                                                   20


<210>  29095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29095
ccuacaaagc ggggggacaa                                                   20


<210>  29096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29096
uguccccccg cuuuguagga                                                   20


<210>  29097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29097
gagugggggc uauuaaccuu                                                   20


<210>  29098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29098
cggagugcaa gguugagcau                                                   20


<210>  29099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29099
cauguggcug guuaccaugc                                                   20


<210>  29100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29100
uccucaaaga uggaaaacac                                                   20


<210>  29101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29101
aucuuugagg aggaauugac                                                   20


<210>  29102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29102
uccugaguga uauuaauaug                                                   20


<210>  29103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29103
uggccaucac caaagagcau                                                   20


<210>  29104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29104
cggcaugggg gagagggacc                                                   20


<210>  29105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29105
caccuccuag ugaccaggaa                                                   20


<210>  29106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29106
uggucacuag gaggugagaa                                                   20


<210>  29107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29107
agccagguca aucaauagaa                                                   20


<210>  29108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29108
auugauugac cuggcuggaa                                                   20


<210>  29109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29109
ugcuugguua ugacuuucua                                                   20


<210>  29110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29110
gaugaagaca ccaaccaugc                                                   20


<210>  29111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29111
ucugaaacaa aagucucagu                                                   20


<210>  29112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29112
aaagcauaaa cucucuugaa                                                   20


<210>  29113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29113
agagaguuua ugcuuuagaa                                                   20


<210>  29114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29114
uuaaagucuu uucaagagag                                                   20


<210>  29115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29115
ugccuuucuu uaaagucuuu                                                   20


<210>  29116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29116
ccaacaucaa uaaagcagga                                                   20


<210>  29117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29117
ugcaccgucu cuuccuggga                                                   20


<210>  29118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29118
ugggaguguu caaagucagg                                                   20


<210>  29119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29119
aagucaggau aauacuuaca                                                   20


<210>  29120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29120
gaucuuguaa guauuauccu                                                   20


<210>  29121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29121
ugguauaaag uguucagauc                                                   20


<210>  29122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29122
uaaucagucu uuuaaacacc                                                   20


<210>  29123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29123
cuuucuuaau cagucuuuua                                                   20


<210>  29124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29124
auucacuuuc uuaaucaguc                                                   20


<210>  29125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29125
ccugccuuag ccucccgagu                                                   20


<210>  29126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29126
aguaauucuc cugccuuagc                                                   20


<210>  29127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29127
uuuuuuuuuu uuuugagaca                                                   20


<210>  29128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29128
uuucuuuuuu uuuuuuuuug                                                   20


<210>  29129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29129
uuucuuuucu uuuuuuuuuu                                                   20


<210>  29130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29130
cccacauuau ccuccugagu                                                   20


<210>  29131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29131
agaccagccu gggcaucaca                                                   20


<210>  29132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29132
ucucugaacu ucccuaccuu                                                   20


<210>  29133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29133
gagaggaagc ccuuuuagca                                                   20


<210>  29134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29134
cuaccuuucu ucuguuuccc                                                   20


<210>  29135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29135
ucuguuuccc ugggcuaggg                                                   20


<210>  29136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29136
guuucccugg gcuagggcuc                                                   20


<210>  29137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29137
cugggcuagg gcuccauguu                                                   20


<210>  29138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29138
ugguccccgg gucucccaau                                                   20


<210>  29139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29139
aggguagcuc ccucaacacc                                                   20


<210>  29140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29140
caagccagga gcgucucccu                                                   20


<210>  29141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29141
ggucucucag aucuacuggu                                                   20


<210>  29142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29142
cuacuuauuu uugauuuuaa                                                   20


<210>  29143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29143
uaaacuggca cuuggacuua                                                   20


<210>  29144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29144
aaacucaagu auaugucuca                                                   20


<210>  29145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29145
gccucugagc agaucuguuu                                                   20


<210>  29146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29146
gggugacccu aggcugcacc                                                   20


<210>  29147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29147
uucuggaagc gggguaaccu                                                   20


<210>  29148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29148
ggaagcgggg uaaccuuccu                                                   20


<210>  29149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29149
agaaugaaua cauuuaucca                                                   20


<210>  29150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29150
uuaccaguuc cgccaggacc                                                   20


<210>  29151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29151
gccaggaccu gucgaauagu                                                   20


<210>  29152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29152
acagguccug gcggaacugg                                                   20


<210>  29153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29153
uauauuacag guacagagcu                                                   20


<210>  29154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29154
gacggcuacc ucuggauccu                                                   20


<210>  29155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29155
cugauguucu gacggcuacc                                                   20


<210>  29156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29156
caguagcugg gaccacaggc                                                   20


<210>  29157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29157
agugauccuc cuugcucagc                                                   20


<210>  29158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29158
aggcaagccu gggcaacaua                                                   20


<210>  29159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29159
ucaaaaaaga aaaaaagacu                                                   20


<210>  29160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29160
aaaaagaaaa aaagacugga                                                   20


<210>  29161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29161
uuuuugaaga agacaggguc                                                   20


<210>  29162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29162
agucuuuuuu ucuuuuuuga                                                   20


<210>  29163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29163
uccaacuuuc gaaggaauuc                                                   20


<210>  29164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29164
aacuuucgaa ggaauucaaa                                                   20


<210>  29165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29165
aaggaauuca aagccccuga                                                   20


<210>  29166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29166
aaaguuggaa gaaugugcac                                                   20


<210>  29167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29167
uucgaaaguu ggaagaaugu                                                   20


<210>  29168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29168
aagccccuga aaaaugaagg                                                   20


<210>  29169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29169
ggggcuuuga auuccuucga                                                   20


<210>  29170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29170
uuuuucaggg gcuuugaauu                                                   20


<210>  29171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29171
cuucauuuuu caggggcuuu                                                   20


<210>  29172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29172
uuucccuuca uuuuucaggg                                                   20


<210>  29173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29173
ucucauuuga uuaguuuccc                                                   20


<210>  29174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29174
cucaaaauga acuuucauuu                                                   20


<210>  29175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29175
uuuugaggga aacuaaucaa                                                   20


<210>  29176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29176
uuuuuggcau ugcauagccu                                                   20


<210>  29177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29177
aggcuaugca augccaaaaa                                                   20


<210>  29178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29178
aaagagggag caguucacau                                                   20


<210>  29179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29179
cugggugugg uggugggcgc                                                   20


<210>  29180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29180
ccguguuagc cggguggucu                                                   20


<210>  29181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29181
aucucaaaaa aaaaaaaaca                                                   20


<210>  29182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29182
gggagccgag aucaggccau                                                   20


<210>  29183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29183
ggcgauuccc cugucucagc                                                   20


<210>  29184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29184
ccugucucag ccucccgagu                                                   20


<210>  29185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29185
ccauguuggu cgggcugguc                                                   20


<210>  29186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29186
agaccagccc gaccaacaug                                                   20


<210>  29187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29187
agcaauuauc ccugccucag                                                   20


<210>  29188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29188
acuauuuaaa aauuauuuau                                                   20


<210>  29189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29189
gccucccaaa gugcugagau                                                   20


<210>  29190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29190
ugacaagccu gaucaacaua                                                   20


<210>  29191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29191
cuauguugau caggcuuguc                                                   20


<210>  29192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29192
ccaguagcua ggauuacugg                                                   20


<210>  29193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29193
ccugccucag auuccccagu                                                   20


<210>  29194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29194
agugauucuc cugccucaga                                                   20


<210>  29195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29195
acuauauaua uauauauuuu                                                   20


<210>  29196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29196
uuuaugcuuu agugcuuuug                                                   20


<210>  29197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29197
agacaccaaa agcacuaaag                                                   20


<210>  29198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29198
cuuuacccaa ggucaugagg                                                   20


<210>  29199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29199
cauuuagguc uauaauuaaa                                                   20


<210>  29200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29200
uuaauuauag accuaaaugu                                                   20


<210>  29201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29201
ccccgguuug gguaucuagu                                                   20


<210>  29202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29202
guauuaacuu caauuuaaaa                                                   20


<210>  29203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29203
auuuaaaagg ccauucuuuc                                                   20


<210>  29204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29204
uuccauagua uuguagaaug                                                   20


<210>  29205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29205
auaguauugu agaaugccau                                                   20


<210>  29206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29206
acaauacuau ggaaagaaug                                                   20


<210>  29207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29207
uaccuugguu auaaauuuag                                                   20


<210>  29208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29208
auauuccuuc gucuacuuuu                                                   20


<210>  29209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29209
uucgucuacu uuucuauccu                                                   20


<210>  29210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29210
ucuacuuuuc uauccuugag                                                   20


<210>  29211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29211
auccuugagc ggccaguacc                                                   20


<210>  29212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29212
gagagugugg uacuggccgc                                                   20


<210>  29213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29213
caacaacaac aaaugcuaua                                                   20


<210>  29214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29214
agccugggca acagagcaag                                                   20


<210>  29215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29215
caccucagcc uccugagugg                                                   20


<210>  29216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29216
agaccgccug agcaacagag                                                   20


<210>  29217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29217
cccaagccuc ccaaagugcu                                                   20


<210>  29218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29218
guauuguucu ucaugaaugu                                                   20


<210>  29219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29219
ucaugaaugu uuugguuauu                                                   20


<210>  29220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29220
ugaauguuuu gguuauucuu                                                   20


<210>  29221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29221
ugaagaacaa uacagaacgc                                                   20


<210>  29222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29222
uggcccuuua uaauuuuaug                                                   20


<210>  29223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29223
cauaaagcac auaaaauuau                                                   20


<210>  29224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29224
guaucuuagu ccguuugugu                                                   20


<210>  29225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29225
uuauagcaac acaaacggac                                                   20


<210>  29226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29226
gcaagcugug uaagaagcau                                                   20


<210>  29227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29227
uacacagcuu gcagaaccag                                                   20


<210>  29228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29228
acuuacggca caaggugaag                                                   20


<210>  29229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29229
ccuugugccg uaaguggaaa                                                   20


<210>  29230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29230
cucaucaugu caucuggaca                                                   20


<210>  29231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29231
caucucucuu gcuuuuucuc                                                   20


<210>  29232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29232
cugagagcua gcuguuaaaa                                                   20


<210>  29233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29233
auuaguuccc ugagagcuag                                                   20


<210>  29234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29234
cauuccauua guucccugag                                                   20


<210>  29235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29235
agcacugagu gaguucucau                                                   20


<210>  29236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29236
ugagggaccu gcccucauga                                                   20


<210>  29237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29237
cauuaggccc accuccagca                                                   20


<210>  29238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29238
ccucagacuc cugagcagcu                                                   20


<210>  29239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29239
gggcucaagc gauccuuuca                                                   20


<210>  29240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29240
agacuagccu ggcgaccuag                                                   20


<210>  29241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29241
agcuacuugg cagacugagg                                                   20


<210>  29242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29242
uuuauuuaca uauuuugaga                                                   20


<210>  29243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29243
uuuucuuuua uuuacauauu                                                   20


<210>  29244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29244
aaauuuuuuu cuuuuucuuu                                                   20


<210>  29245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29245
uuucaaaauu uuuuucuuuu                                                   20


<210>  29246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29246
gaguugucca ccccagcucu                                                   20


<210>  29247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29247
uucagaguug uccaccccag                                                   20


<210>  29248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29248
cugaaaagga aggaaaagau                                                   20


<210>  29249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29249
gugaauuccu ucagaguugu                                                   20


<210>  29250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29250
uuuucaguga auuccuucag                                                   20


<210>  29251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29251
uuccuuuuca gugaauuccu                                                   20


<210>  29252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29252
cucacugccu aucuuuuccu                                                   20


<210>  29253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29253
gccccagcuu cucucacugc                                                   20


<210>  29254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29254
ucagaguggg agacagcaua                                                   20


<210>  29255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29255
gagugggaga cagcauauuu                                                   20


<210>  29256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29256
auuaggaugc aaauaugcug                                                   20


<210>  29257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29257
ugcaucacuu ccauuaggau                                                   20


<210>  29258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29258
uuccugcauc acuuccauua                                                   20


<210>  29259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29259
cuuucuuucc ugcaucacuu                                                   20


<210>  29260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29260
cauaucauca cuuucucuuu                                                   20


<210>  29261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29261
guccucuucu cauaucauca                                                   20


<210>  29262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29262
caaccagacc ccacccuguc                                                   20


<210>  29263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29263
cagcucccac acauccgcag                                                   20


<210>  29264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29264
aaaagauugc uggugcucac                                                   20


<210>  29265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29265
cagacugcug aggguggugu                                                   20


<210>  29266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29266
uuuauacucc ucagcacaga                                                   20


<210>  29267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29267
ucccuccugg gcacccugcu                                                   20


<210>  29268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29268
cuccugggca cccugcuccg                                                   20


<210>  29269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29269
ucucaacuuc caucauuagg                                                   20


<210>  29270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29270
aucauuaggc ucagggaccu                                                   20


<210>  29271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29271
cuguguccug ccgugaaagu                                                   20


<210>  29272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29272
cggcaggaca cagggaaagg                                                   20


<210>  29273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29273
ggugccucuu uaccuuaagu                                                   20


<210>  29274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29274
cauaauacaa uguugauaaa                                                   20


<210>  29275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29275
auaaaaaagc aaguauugcc                                                   20


<210>  29276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29276
ggucacuuaa uuuugagaug                                                   20


<210>  29277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29277
auguguuguc ucugaauaaa                                                   20


<210>  29278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29278
gagacaacac auggaauagg                                                   20


<210>  29279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29279
gccucuguuc uauuuaagua                                                   20


<210>  29280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29280
auuuaaguag uuuuauuuuu                                                   20


<210>  29281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29281
cucuggucau uucuggguau                                                   20


<210>  29282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29282
ggguauugcu guaaagacug                                                   20


<210>  29283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29283
ggaccuucag agauugaagg                                                   20


<210>  29284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29284
gagauugaag gguuacaaac                                                   20


<210>  29285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29285
aucucugaag guccugaaaa                                                   20


<210>  29286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29286
cacacugcag uuuguaaccc                                                   20


<210>  29287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29287
uugccaaucu uuaaaguaaa                                                   20


<210>  29288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29288
aacauaccgu ucuuugccaa                                                   20


<210>  29289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29289
agcuguuuug cccuuuugcu                                                   20


<210>  29290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29290
ggcuccauac agcaaaaggg                                                   20


<210>  29291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29291
agucucuaca uucaggcucc                                                   20


<210>  29292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29292
uaucccugcu cugucauggg                                                   20


<210>  29293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29293
gaggcuggcu cagauauuug                                                   20


<210>  29294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29294
ucuggauaag uagcaucaaa                                                   20


<210>  29295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29295
ggauaaguag caucaaaaca                                                   20


<210>  29296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29296
uauacaaaug uaguugccgu                                                   20


<210>  29297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29297
ccauguaaug uuacuaaugu                                                   20


<210>  29298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29298
agcaaauacc acuaugccuu                                                   20


<210>  29299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29299
uuaaugccuu aaaaccaucu                                                   20


<210>  29300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29300
acagauguaa auaagauggu                                                   20


<210>  29301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29301
ggagcaauca uuaaaaacag                                                   20


<210>  29302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29302
uuagguuuuc ucuguuuauu                                                   20


<210>  29303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29303
cuguuuauuc uaauauguaa                                                   20


<210>  29304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29304
aauauguaaa cugaaauuaa                                                   20


<210>  29305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29305
guuuacauau uagaauaaac                                                   20


<210>  29306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29306
gaguucauuc uuuaaaaaaa                                                   20


<210>  29307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29307
uucuuuaaaa aaaguaaguc                                                   20


<210>  29308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29308
uuaaaaaaag uaaguccuaa                                                   20


<210>  29309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29309
uuaggacuua cuuuuuuuaa                                                   20


<210>  29310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29310
acauuauuac agcauccuuu                                                   20


<210>  29311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29311
acagugacug auucuacauu                                                   20


<210>  29312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29312
auggaacagc cuugaaauua                                                   20


<210>  29313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29313
auggaaacuc aauaaaauuc                                                   20


<210>  29314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29314
aggcuguucc auggaaacuc                                                   20


<210>  29315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29315
guaaucuuac agaguaaaua                                                   20


<210>  29316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29316
cagugguuac aaagagauug                                                   20


<210>  29317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29317
cugagcaaaa ggcauugccu                                                   20


<210>  29318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29318
caaagcauau gcagguucuc                                                   20


<210>  29319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29319
ggaaagaaag ggugaaaagg                                                   20


<210>  29320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29320
ugaacucagc uuucccaaag                                                   20


<210>  29321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29321
uuccugaacu cagcuuuccc                                                   20


<210>  29322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29322
cccuuucuuu ccugaacuca                                                   20


<210>  29323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29323
cuggacuuga gugcagguag                                                   20


<210>  29324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29324
ugaccucgug aucugccuac                                                   20


<210>  29325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29325
ucacgucggu caggcugauc                                                   20


<210>  29326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29326
ccugccucag ccuccugagu                                                   20


<210>  29327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29327
agcaauucuc cugccucagc                                                   20


<210>  29328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29328
uuuuuuuuuu uuuugagaca                                                   20


<210>  29329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29329
uucuuuuuuu uuuuuuuuga                                                   20


<210>  29330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29330
uucuuucuuu uuuuuuuuuu                                                   20


<210>  29331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29331
gcauuuuuau auaugauccu                                                   20


<210>  29332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29332
ccacguuggc caggaugguc                                                   20


<210>  29333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29333
aaugauccuc cugccucagc                                                   20


<210>  29334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29334
agccugguga cagagcgaga                                                   20


<210>  29335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29335
guuuuuuaau uuuguuuugu                                                   20


<210>  29336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29336
guucccuuag cauuuacugg                                                   20


<210>  29337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29337
cuuagcauuu acugggcgcc                                                   20


<210>  29338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29338
uaauguugag ugucuaaugg                                                   20


<210>  29339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29339
cauuagacac ucaacauuau                                                   20


<210>  29340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29340
cauguccauc uucccauuag                                                   20


<210>  29341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29341
uuauacuaca aaauuaucuu                                                   20


<210>  29342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29342
uauagacuau cauauauuca                                                   20


<210>  29343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29343
acacuuccua uagacuauca                                                   20


<210>  29344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29344
ccauguuagc caggaugguc                                                   20


<210>  29345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29345
ccugccucag ccuaccaagu                                                   20


<210>  29346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29346
agugauucuc cugccucagc                                                   20


<210>  29347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29347
acacucuuuu uuuuuuuuug                                                   20


<210>  29348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29348
cagaauaaaa aaguuaccau                                                   20


<210>  29349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29349
gugaauuuug cucccuaccc                                                   20


<210>  29350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29350
aaccccacua ugguaacuuu                                                   20


<210>  29351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29351
uuuacaagac aacugcgagg                                                   20


<210>  29352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29352
cuaaaacacc aaucuccccg                                                   20


<210>  29353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29353
uacuugcugc uugcuucccu                                                   20


<210>  29354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29354
ugccuucaua cuugcugcuu                                                   20


<210>  29355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29355
acacucccgc cccaaccaac                                                   20


<210>  29356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29356
agugggugau uuugcaagaa                                                   20


<210>  29357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29357
ugcaaaauca cccacuugaa                                                   20


<210>  29358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29358
ugcugccuaa aaagaucaag                                                   20


<210>  29359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29359
auuguuccug cugccuaaaa                                                   20


<210>  29360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29360
cugccuuaaa cccuucgauu                                                   20


<210>  29361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29361
ggucauaggu acagugugag                                                   20


<210>  29362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29362
gggcugucug cuccccacau                                                   20


<210>  29363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29363
uagggcgguc uaaucugggu                                                   20


<210>  29364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29364
ucauguuuau aagaaguuua                                                   20


<210>  29365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29365
uguuuauaag aaguuuaucu                                                   20


<210>  29366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29366
uauaaacaug aagaaaaaag                                                   20


<210>  29367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29367
uguuuaauuu ggaauuucau                                                   20


<210>  29368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29368
aaauuaaaca ugaaaaccca                                                   20


<210>  29369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29369
uuuuggaaac aaauuucaaa                                                   20


<210>  29370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29370
aaaaugaaau uccaaauuaa                                                   20


<210>  29371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29371
aaacuagaau auaagccuag                                                   20


<210>  29372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29372
aguuuugaaa uuuguuucca                                                   20


<210>  29373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29373
ugcuaggcuu auauucuagu                                                   20


<210>  29374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29374
accacccagu gacuguggcc                                                   20


<210>  29375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29375
gaaaagguaa aauacaucau                                                   20


<210>  29376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29376
gaauaaacug auuuucuacc                                                   20


<210>  29377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29377
accaucuaug auguauuuua                                                   20


<210>  29378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29378
caaaguguuu ucagcaauac                                                   20


<210>  29379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29379
gcaauacugc caucuuagcc                                                   20


<210>  29380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29380
ccuaugcaaa aauuucuggg                                                   20


<210>  29381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29381
ggguuaucuu ggucccuuac                                                   20


<210>  29382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29382
ucuauguguu uguaggauuu                                                   20


<210>  29383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29383
uucugguaca uauauauaau                                                   20


<210>  29384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29384
gguacauaua uauaauuuuu                                                   20


<210>  29385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29385
agccugggca aacagagcaa                                                   20


<210>  29386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29386
agugauucuc cugccucagc                                                   20


<210>  29387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29387
ccugccucag cuugaguagc                                                   20


<210>  29388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29388
ccacguuggc caggcugguc                                                   20


<210>  29389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29389
agaccagccu ggccaacgug                                                   20


<210>  29390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29390
gcuuccaagc aagagguagu                                                   20


<210>  29391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29391
aagcaagagg uaguaacuag                                                   20


<210>  29392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29392
aguuacuacc ucuugcuugg                                                   20


<210>  29393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29393
ugucucaaac agugaaacaa                                                   20


<210>  29394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29394
cuguuugaga caggaagaua                                                   20


<210>  29395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29395
aacauuggcc cacaggcagg                                                   20


<210>  29396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29396
cucagggauc acuguccugc                                                   20


<210>  29397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29397
ucucucaggg aucacugucc                                                   20


<210>  29398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29398
ucuucucuca gggaucacug                                                   20


<210>  29399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29399
ugccuggaga gagucugaag                                                   20


<210>  29400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29400
gacucucucc aggcaggaag                                                   20


<210>  29401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29401
ccucuuugca gcucucuccu                                                   20


<210>  29402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29402
uuccccucuu ugcagcucuc                                                   20


<210>  29403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29403
ccccaagccc agcugagggc                                                   20


<210>  29404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29404
ccacaggcau gugcuuaugc                                                   20


<210>  29405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29405
agggugcuag cccaggcgca                                                   20


<210>  29406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29406
caccagccau ugugggaaaa                                                   20


<210>  29407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29407
cacaauggcu ggugggaaca                                                   20


<210>  29408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29408
ucuuacccac aacugaggca                                                   20


<210>  29409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29409
gaugcugccu uacagagccu                                                   20


<210>  29410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29410
gggcuuguag gcucuguaag                                                   20


<210>  29411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29411
caaacaaccc uccuauggcc                                                   20


<210>  29412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29412
ucaugggcca uaggaggguu                                                   20


<210>  29413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29413
guaucugagc uucgucaugg                                                   20


<210>  29414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29414
uucaguaucu gagcuucguc                                                   20


<210>  29415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29415
uuccuucagu aucugagcuu                                                   20


<210>  29416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29416
uacuuguccc uagcucuucu                                                   20


<210>  29417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29417
ccuccucuca caccucacag                                                   20


<210>  29418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29418
cagccuuauc cacuucccuu                                                   20


<210>  29419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29419
cuuccugcag cccuggucca                                                   20


<210>  29420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29420
ugcagcccug guccaagcug                                                   20


<210>  29421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29421
ggagccagac agcagcagcu                                                   20


<210>  29422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29422
ucccauuguc ccaucccauc                                                   20


<210>  29423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29423
cauuguccca ucccaucucu                                                   20


<210>  29424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29424
guggcccuca gcucuccccc                                                   20


<210>  29425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29425
gcucuuguca gccccaugcc                                                   20


<210>  29426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29426
ggggucuccu caaggaggcc                                                   20


<210>  29427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29427
uugcuguuau guuuuucucc                                                   20


<210>  29428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29428
ccuuaucacu auuuaauuag                                                   20


<210>  29429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29429
uguauuuguc uuauuuauug                                                   20


<210>  29430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29430
ucaccauugu gcccucagug                                                   20


<210>  29431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29431
ccauugugcc cucagugccu                                                   20


<210>  29432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29432
ccagucaucc aggauuuacu                                                   20


<210>  29433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29433
ggcucuuaac auuaugauuu                                                   20


<210>  29434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29434
guaauuaaaa gggcaagcca                                                   20


<210>  29435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29435
ggcuugcccu uuuaauuaca                                                   20


<210>  29436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29436
gccagugaug ggagcuguuu                                                   20


<210>  29437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29437
aagaccugag gaaaagagau                                                   20


<210>  29438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29438
ucaggucuua gaaaacagcu                                                   20


<210>  29439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29439
auaccaacaa aucccaaaag                                                   20


<210>  29440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29440
caugguacuc ggugguuuga                                                   20


<210>  29441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29441
cuaggacacu guggggaggu                                                   20


<210>  29442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29442
gcucaggaug gcugcugagc                                                   20


<210>  29443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29443
caaacccagc ucagcagcca                                                   20


<210>  29444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29444
uggaaacaug ugagaauaua                                                   20


<210>  29445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29445
augaaccagu gaucaaaacu                                                   20


<210>  29446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29446
cacauguuuc caugaaccag                                                   20


<210>  29447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29447
uauauauucu cacauguuuc                                                   20


<210>  29448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29448
uucuuucaau cacuaauuca                                                   20


<210>  29449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29449
uucaaucacu aauucauuca                                                   20


<210>  29450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29450
aucacuaauu cauucauuua                                                   20


<210>  29451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29451
uucauuuaua cauucagccc                                                   20


<210>  29452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29452
uuuauacauu cagccccuug                                                   20


<210>  29453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29453
gccccuuguu uaaauaugug                                                   20


<210>  29454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29454
ugccggucag caggaagucu                                                   20


<210>  29455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29455
ugcugaccgg caggaagcac                                                   20


<210>  29456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29456
uaagacuucc ugcugaccgg                                                   20


<210>  29457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29457
ggggccaauc cguuauguac                                                   20


<210>  29458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29458
aaaggaccca cuguacauaa                                                   20


<210>  29459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29459
cacagccucg agcugucucc                                                   20


<210>  29460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29460
ccaaggccgg cuagaccugu                                                   20


<210>  29461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29461
ggguggagau ggagacugaa                                                   20


<210>  29462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29462
gucuccaucu ccacccagaa                                                   20


<210>  29463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29463
ggcuuuucag ucuccaucuc                                                   20


<210>  29464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29464
caccuggcau gucuugcagc                                                   20


<210>  29465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29465
cucaccucca ccccacugug                                                   20


<210>  29466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29466
ggcugccucu ggaaggccag                                                   20


<210>  29467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29467
agaggcagcc agaaaaaggg                                                   20


<210>  29468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29468
cuuugcccug cucccuggga                                                   20


<210>  29469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29469
aaggggcuuc cuccuaaggu                                                   20


<210>  29470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29470
aacccugagg agaggcugga                                                   20


<210>  29471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29471
uccuaaggug cagaggcagc                                                   20


<210>  29472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29472
cacagggcug ccucugcacc                                                   20


<210>  29473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29473
aguuguguga gacucaguuu                                                   20


<210>  29474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29474
uucuuuuucu uuucuuuucc                                                   20


<210>  29475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29475
uuuucuuuuc uuuuccuuuu                                                   20


<210>  29476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29476
uuucuuuucc uuuuuuuuuu                                                   20


<210>  29477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29477
uuuccuuuuu uuuuuuuuuu                                                   20


<210>  29478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29478
uuuuuuuuuu uuuuuuuuuu                                                   20


<210>  29479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29479
agccugggca auagagcaag                                                   20


<210>  29480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29480
agguucaaac gauucuccug                                                   20


<210>  29481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29481
aacgauucuc cugcgucagc                                                   20


<210>  29482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29482
ccugcgucag ccuccugagu                                                   20


<210>  29483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29483
auuaaaaaca caaaauuagc                                                   20


<210>  29484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29484
ccauguuggc caggcuggau                                                   20


<210>  29485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29485
uucuuuuuuu uuuuugacac                                                   20


<210>  29486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29486
uuuuuuuuuu ugacacgggg                                                   20


<210>  29487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29487
ccucugcaaa aaauccaacu                                                   20


<210>  29488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29488
guuucuuuuu cuguauuugu                                                   20


<210>  29489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29489
uuuucuguau uuguguuuua                                                   20


<210>  29490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29490
guauuugugu uuuaaaggcu                                                   20


<210>  29491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29491
gauagagugg gugguuaucu                                                   20


<210>  29492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29492
uccuaccucu aaggccucuu                                                   20


<210>  29493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29493
ccuugcccca cauuguagga                                                   20


<210>  29494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29494
aauagguccu acaauguggg                                                   20


<210>  29495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29495
aggcccagca guaaugaugc                                                   20


<210>  29496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29496
agauaaacag ggagcugaug                                                   20


<210>  29497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29497
agauucaaga uaaacaggga                                                   20


<210>  29498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29498
ggcuuaagug ugucugcaga                                                   20


<210>  29499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29499
agauggcaau ucuggcuuaa                                                   20


<210>  29500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29500
agaggcaucu gcacaccagg                                                   20


<210>  29501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29501
gacuucguug gugguaacca                                                   20


<210>  29502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29502
uuggugguaa ccaguucugg                                                   20


<210>  29503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29503
gguaaacagu cugaaaauug                                                   20


<210>  29504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29504
gacuguuuac cagaacuggu                                                   20


<210>  29505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29505
agcauguggu ggaaaaguaa                                                   20


<210>  29506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29506
accacaugcu agaaacuguc                                                   20


<210>  29507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29507
accugggucg cugggcacug                                                   20


<210>  29508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29508
cgcccgugag ugagguagcg                                                   20


<210>  29509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29509
ccccccaggg gccucguccc                                                   20


<210>  29510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29510
ccgcccaccc ugagguaccg                                                   20


<210>  29511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29511
agacgcggag accgcccccc                                                   20


<210>  29512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29512
gggcgggggc cggguguccc                                                   20


<210>  29513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29513
caccccucgc gccccucugg                                                   20


<210>  29514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29514
cggaauccaa acuucccucu                                                   20


<210>  29515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29515
gggaagggcg gagagcgagu                                                   20


<210>  29516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29516
cucugcagcg gccgcgcuuc                                                   20


<210>  29517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29517
cggagggcaa gaaaagccgc                                                   20


<210>  29518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29518
ugcccuccgu gaagcgcggc                                                   20


<210>  29519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29519
cacugaagug ugagugacug                                                   20


<210>  29520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29520
gugugaauca gcgccagugg                                                   20


<210>  29521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29521
cuguugccca ugagagucuc                                                   20


<210>  29522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29522
accuguacgc uggccucccu                                                   20


<210>  29523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29523
cgcugcucug ggccucggcu                                                   20


<210>  29524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29524
gcuggugcuc cuuuccguga                                                   20


<210>  29525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29525
gugagcaccu ccuauccccu                                                   20


<210>  29526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29526
aauuggcugu ggccaggggc                                                   20


<210>  29527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29527
aaggacuuaa guguggccac                                                   20


<210>  29528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29528
acacauugca ucaccggccc                                                   20


<210>  29529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29529
acaaccgccu gaaggcaggg                                                   20


<210>  29530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29530
ggcgguugug gaaacaauuc                                                   20


<210>  29531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29531
gcaaggagga ggcugugggc                                                   20


<210>  29532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29532
ggucagcccu gcaccaacuc                                                   20


<210>  29533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29533
ucccacucug uccacugucu                                                   20


<210>  29534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29534
cacucugucc acugucuccu                                                   20


<210>  29535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29535
acggugucua cguagaggag                                                   20


<210>  29536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29536
gucuaucccc ucucccugcc                                                   20


<210>  29537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29537
gccugccccc uccagggugu                                                   20


<210>  29538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29538
uucugccugc ccccuccagg                                                   20


<210>  29539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29539
uagacacggc ugccuaucug                                                   20


<210>  29540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29540
gggagucccc aggccuccag                                                   20


<210>  29541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29541
ggccagccuc cuuggugggc                                                   20


<210>  29542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29542
gcccacaugg acagaggaag                                                   20


<210>  29543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29543
ucuguccaug ugggcagaaa                                                   20


<210>  29544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29544
cgucuguggg ccugcuugug                                                   20


<210>  29545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29545
ugaggggcag ggaggaaggg                                                   20


<210>  29546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29546
ucccugcccc ucaggaacca                                                   20


<210>  29547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29547
cacccaagau ccuggcugag                                                   20


<210>  29548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29548
agcuguguga ucauggccag                                                   20


<210>  29549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29549
cccugccacc ccuccguuuu                                                   20


<210>  29550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29550
cauccaugac cugagggcug                                                   20


<210>  29551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29551
cagcccucag gucauggaug                                                   20


<210>  29552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29552
gugacagugg gucgcugagg                                                   20


<210>  29553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29553
ugcccacauu ggacuaaggc                                                   20


<210>  29554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29554
ugcguucugu ccucaaaagc                                                   20


<210>  29555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29555
guccucaaaa gcucccuugu                                                   20


<210>  29556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29556
uuaauaaccg gguggcuugg                                                   20


<210>  29557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29557
ccucacccac ccaggcugca                                                   20


<210>  29558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29558
ccgccagccu gcccuucucc                                                   20


<210>  29559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29559
ccgucuuuuc cccgccagcc                                                   20


<210>  29560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29560
uuggcccgag gggugggagc                                                   20


<210>  29561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29561
ccuugccucc caggccccuc                                                   20


<210>  29562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29562
agggucugca cggccccuuc                                                   20


<210>  29563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29563
uccaggauag gcggcuccuc                                                   20


<210>  29564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29564
ggggaggagc cgccuauccu                                                   20


<210>  29565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29565
ucugguggcc cugucuggac                                                   20


<210>  29566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29566
gguggcccug ucuggacacc                                                   20


<210>  29567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29567
ggcucacugg cuggcccccu                                                   20


<210>  29568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29568
cuggggcacu ggacccuccu                                                   20


<210>  29569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29569
ccuacaaggc ucaggucucc                                                   20


<210>  29570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29570
ugacccucag uuuccugauc                                                   20


<210>  29571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29571
ugaucugcaa aacgggauga                                                   20


<210>  29572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29572
gucaucccgu uuugcagauc                                                   20


<210>  29573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29573
gugccgggcc ccugacuaca                                                   20


<210>  29574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29574
agggugacgc gagagaagca                                                   20


<210>  29575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29575
cucgcgucac ccuugaagga                                                   20


<210>  29576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29576
gggcgggugg agaccugggu                                                   20


<210>  29577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29577
agguggugca ggcucccagg                                                   20


<210>  29578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29578
ccccuccugg gagccugcac                                                   20


<210>  29579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29579
cucuucuccc caggcucugu                                                   20


<210>  29580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29580
ccccaggcuc uguaacuucc                                                   20


<210>  29581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29581
aaggccauga gaguggucag                                                   20


<210>  29582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29582
cggcccccga ucacagaucg                                                   20


<210>  29583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29583
agcacgaucu gugaucgggg                                                   20


<210>  29584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29584
ucauggauuc cggucacauc                                                   20


<210>  29585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29585
uggauuccgg ucacaucugg                                                   20


<210>  29586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29586
ggucacaucu gguccaucuu                                                   20


<210>  29587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29587
cagaggccag cugacaaaga                                                   20


<210>  29588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29588
ucccagaggc cagcugacaa                                                   20


<210>  29589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29589
aagaagugcc cucugcuucc                                                   20


<210>  29590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29590
uggaaucagc ucagcuacag                                                   20


<210>  29591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29591
uugugaauca gauguuuacu                                                   20


<210>  29592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29592
caaggaagca gagggcacuu                                                   20


<210>  29593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29593
ugaggcuguu gccugccagc                                                   20


<210>  29594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29594
cucggccccu gccucgcggc                                                   20


<210>  29595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29595
cucaggcacc agaggggagc                                                   20


<210>  29596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29596
gggcucagag caggcuucgu                                                   20


<210>  29597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29597
ucugagggcu ucagcguccu                                                   20


<210>  29598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29598
gcguccuccu ugugaaaugg                                                   20


<210>  29599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29599
caaggaggac gcugaagccc                                                   20


<210>  29600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29600
ccccauuuca caaggaggac                                                   20


<210>  29601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29601
cacaguguca agggcaggga                                                   20


<210>  29602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29602
uucagccucg auccaggggu                                                   20


<210>  29603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29603
gccucgaucc agggguguug                                                   20


<210>  29604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29604
guggcauuug aggguccugg                                                   20


<210>  29605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29605
caccuugucc aggggcagcc                                                   20


<210>  29606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29606
gggagccugg aaugcugggc                                                   20


<210>  29607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29607
aggcucccag aaugaccccu                                                   20


<210>  29608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29608
cagccuuggg agucuggggc                                                   20


<210>  29609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29609
gccucugggg caguggugga                                                   20


<210>  29610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29610
gaaggcugcu gcccagcccc                                                   20


<210>  29611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29611
gaaggagguc caccacugcc                                                   20


<210>  29612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29612
aagggagaga guggcaaggu                                                   20


<210>  29613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29613
gcugaagaca uaagugucug                                                   20


<210>  29614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29614
gcugaaauug cuucuaaggg                                                   20


<210>  29615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29615
ugagccccca gccuggucua                                                   20


<210>  29616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29616
caagcaggag gggcaggcgg                                                   20


<210>  29617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29617
ugaguuccca agcaggaggg                                                   20


<210>  29618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29618
ucugggacag gcccacgugg                                                   20


<210>  29619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29619
cugcccagga gugggaggcu                                                   20


<210>  29620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29620
aagagcuugg cacagcccgc                                                   20


<210>  29621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29621
aaucagauaa uaucagacug                                                   20


<210>  29622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29622
ugggagacca aagcacaaca                                                   20


<210>  29623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29623
gguuuccauc acagccuccu                                                   20


<210>  29624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29624
aucacagccu ccucccuucc                                                   20


<210>  29625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29625
cccugcgggc ugcgcuguga                                                   20


<210>  29626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29626
gggccugguc ucgguggccc                                                   20


<210>  29627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29627
ucaccaggcu uugguccucc                                                   20


<210>  29628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29628
gggagaggac aggggacacc                                                   20


<210>  29629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29629
uucagggaga ggacagggga                                                   20


<210>  29630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29630
uucucuguag cugcucuucc                                                   20


<210>  29631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29631
cuguagcugc ucuuccuaaa                                                   20


<210>  29632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29632
uaaacgugug uuggcuugag                                                   20


<210>  29633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29633
caccauuagg agggcaaugg                                                   20


<210>  29634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29634
ccauugcccu ccuaauggug                                                   20


<210>  29635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29635
ggaucuuucc ccauugcccu                                                   20


<210>  29636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29636
uggccugccu ccucuggcuc                                                   20


<210>  29637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29637
gagagaggag augagugccg                                                   20


<210>  29638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29638
ucuccuccua cucgaggcca                                                   20


<210>  29639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29639
ggccucgagu aggaggagag                                                   20


<210>  29640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29640
cuuucuggcc ucgaguagga                                                   20


<210>  29641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29641
agugggguga guggcuggcg                                                   20


<210>  29642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29642
ccucugcccu ggucaaacuc                                                   20


<210>  29643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29643
cccagcucgg gggaugcacc                                                   20


<210>  29644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29644
cguugccauc accucuugug                                                   20


<210>  29645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29645
caggcugaga ccucuaggaa                                                   20


<210>  29646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29646
uagaggucuc agccugggaa                                                   20


<210>  29647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29647
cugggcaggg cagggacagg                                                   20


<210>  29648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29648
ugucccugcc cugcccagag                                                   20


<210>  29649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29649
caggccccgu gcugcgugca                                                   20


<210>  29650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29650
uuccugcugu accccugcug                                                   20


<210>  29651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29651
ugcuguaccc cugcuggcug                                                   20


<210>  29652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29652
uccccaccgg aggagcugcu                                                   20


<210>  29653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29653
acccccaggg ucccgccugg                                                   20


<210>  29654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29654
gagauuccac ccccaggguc                                                   20


<210>  29655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29655
ccucgggacc cucaccgcga                                                   20


<210>  29656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29656
cucagcuuca gacccugggc                                                   20


<210>  29657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29657
gacccugggc ugcagcugcc                                                   20


<210>  29658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29658
ggaagguuug cuacuugggg                                                   20


<210>  29659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29659
ugaagccagc acccaggacc                                                   20


<210>  29660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29660
cauuuucuug aggaugugac                                                   20


<210>  29661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29661
ugaggaugug accaggaggg                                                   20


<210>  29662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29662
ugccccagag gcaggcacag                                                   20


<210>  29663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29663
ccagcaacuu ccugccccag                                                   20


<210>  29664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29664
uuccccagca acuuccugcc                                                   20


<210>  29665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29665
uccuucccca gcaacuuccu                                                   20


<210>  29666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29666
caaucuucuu ccuuccccag                                                   20


<210>  29667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29667
ugccggcugg caucaagggg                                                   20


<210>  29668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29668
agggcuggug uccugagaag                                                   20


<210>  29669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29669
caggacacca gcccuggaau                                                   20


<210>  29670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29670
agggggccug ggucccaagu                                                   20


<210>  29671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29671
aguacgaagc ugggaaaagg                                                   20


<210>  29672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29672
uacuggaagg gccaggaccc                                                   20


<210>  29673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29673
cagcuucgua cuggaagggc                                                   20


<210>  29674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29674
cacagccuga gcccucagcc                                                   20


<210>  29675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29675
aaaccagggu gucuuucaca                                                   20


<210>  29676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29676
agcaggggcu ggcuuauguu                                                   20


<210>  29677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29677
agcuuacucu ggggucugga                                                   20


<210>  29678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29678
gcaguggucu ccagacccca                                                   20


<210>  29679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29679
uguggccacu gcuuggaggg                                                   20


<210>  29680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29680
ccagaccccg cccgagcucc                                                   20


<210>  29681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29681
gucuguggca gcccccaccc                                                   20


<210>  29682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29682
ucgaggcugc agaaggcugg                                                   20


<210>  29683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29683
gcagccucga cgaacccacu                                                   20


<210>  29684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29684
uccccuguag ccccugugca                                                   20


<210>  29685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29685
ggcagacagu ggcauggucc                                                   20


<210>  29686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29686
cuccccaggg aggcagcucu                                                   20


<210>  29687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29687
cagccaggag gaggcccuag                                                   20


<210>  29688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29688
ccugggggcu cuggggaggc                                                   20


<210>  29689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29689
ccccucugag gaaggaccug                                                   20


<210>  29690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29690
ucagaggggu gaauggcucu                                                   20


<210>  29691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29691
gcccccggcc aggucacccc                                                   20


<210>  29692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29692
ccaccugcaa acucccgccu                                                   20


<210>  29693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29693
uccagccguu ccccaccugc                                                   20


<210>  29694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29694
acgaguuccu ccagccguuc                                                   20


<210>  29695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29695
gcugcagccu cagcagaggu                                                   20


<210>  29696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29696
ucccucggag ccagccuguc                                                   20


<210>  29697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29697
caaggccagg ccgcccacag                                                   20


<210>  29698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29698
cggcaggccg ggcccaccgc                                                   20


<210>  29699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29699
gagaggccca gugaggacaa                                                   20


<210>  29700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29700
caggccccuc acaacgcucc                                                   20


<210>  29701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29701
ggucacccag gcccccucug                                                   20


<210>  29702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29702
caggcugagg aggaacacac                                                   20


<210>  29703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29703
uccucagccu gggaacccca                                                   20


<210>  29704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29704
ccaacccggg gucuggccca                                                   20


<210>  29705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29705
uccuucuuuu ugccucucug                                                   20


<210>  29706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29706
uucuuuuugc cucucuguca                                                   20


<210>  29707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29707
uuuugccucu cugucagcac                                                   20


<210>  29708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29708
uguugccucc cucuugcucc                                                   20


<210>  29709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29709
ccuguccggc cagagacccc                                                   20


<210>  29710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29710
uccuggggcc acucacaggc                                                   20


<210>  29711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29711
ugucuaggcu gggucuuguc                                                   20


<210>  29712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29712
uuaguaaauu uuagguuggc                                                   20


<210>  29713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29713
ugucauuuuu uauuccuuag                                                   20


<210>  29714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29714
gcuucuuguc auuuuuuauu                                                   20


<210>  29715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29715
cuugccuucu gcuucuuguc                                                   20


<210>  29716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29716
auucccuugc cuucugcuuc                                                   20


<210>  29717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29717
uuuuuacucu cuggguuuau                                                   20


<210>  29718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29718
cggauguugu ucguuuuuac                                                   20


<210>  29719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29719
aacauggguu uuuuucccgg                                                   20


<210>  29720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29720
agaccagccu gaccaccgug                                                   20


<210>  29721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29721
ccacgguggu caggcugguc                                                   20


<210>  29722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29722
cacgucucag ccucccgagu                                                   20


<210>  29723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29723
agcaauucuc acgucucagc                                                   20


<210>  29724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29724
agaccagccu ggccaacaua                                                   20


<210>  29725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29725
cuauguuggc caggcugguc                                                   20


<210>  29726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29726
ccugccucag ccuccuauag                                                   20


<210>  29727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29727
agcacuucuc cugccucagc                                                   20


<210>  29728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29728
agccugggca ccaaagugag                                                   20


<210>  29729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29729
cuaacguuac gugugugugu                                                   20


<210>  29730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29730
cugugauccu uuuucccuaa                                                   20


<210>  29731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29731
gcugccuuaa ugcauucgcu                                                   20


<210>  29732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29732
gcacuugagg guuaggucuu                                                   20


<210>  29733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29733
cucuguccac ucauuucagc                                                   20


<210>  29734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29734
uggguaagcg aggggcccaa                                                   20


<210>  29735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29735
uaccguggcg gucuuggcgg                                                   20


<210>  29736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29736
cucaucaccg ugguacuuuu                                                   20


<210>  29737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29737
cugacuggcg ccccuacugc                                                   20


<210>  29738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29738
cuuguuaucu cgcccuggug                                                   20


<210>  29739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29739
agggccuagg gacccagugc                                                   20


<210>  29740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29740
cucccugagc cuugcuccgu                                                   20


<210>  29741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29741
cgccugggcu ccagucccag                                                   20


<210>  29742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29742
cugggaugag cuccugggca                                                   20


<210>  29743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29743
aacuaagacc caccucuguc                                                   20


<210>  29744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29744
gacaugagag acagaggugg                                                   20


<210>  29745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29745
cuuaccugca accccagggc                                                   20


<210>  29746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29746
acaugaguua gccaagcaug                                                   20


<210>  29747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29747
acccagacac guugacacau                                                   20


<210>  29748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29748
ggccgagugg agugacacug                                                   20


<210>  29749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29749
gugggcucgg cuggagucau                                                   20


<210>  29750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29750
accauucccu ggccucgguu                                                   20


<210>  29751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29751
cuggccucgg uuuccugcuc                                                   20


<210>  29752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29752
ugcucucggu uuccucagcu                                                   20


<210>  29753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29753
ucagcugccu gguggguucc                                                   20


<210>  29754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29754
acugcaacuc ucuggggguc                                                   20


<210>  29755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29755
gucccggcac cgccugcucc                                                   20


<210>  29756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29756
ucauccgagu cucugcggau                                                   20


<210>  29757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29757
ccaggaguaa cuggggcagu                                                   20


<210>  29758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29758
uugcccgagu uuucucuagg                                                   20


<210>  29759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29759
cuagggugag caccagacca                                                   20


<210>  29760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29760
ucaagggaac cagcagcauu                                                   20


<210>  29761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29761
agggaaccag cagcauugag                                                   20


<210>  29762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29762
cuugaagaaa gaguggucug                                                   20


<210>  29763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29763
caaccagccu ccccaggggc                                                   20


<210>  29764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29764
guuuuaaacu gaucccaaga                                                   20


<210>  29765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29765
ccaggccuuc cuguccugcu                                                   20


<210>  29766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29766
uguccugcug agcugggccc                                                   20


<210>  29767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29767
ucccuguacc ccacauggcg                                                   20


<210>  29768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29768
uucugagagu gggccugggg                                                   20


<210>  29769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29769
gagagugggc cugggguuuc                                                   20


<210>  29770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29770
ccucuccuuc uuacccaccc                                                   20


<210>  29771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29771
uacccacccc agagccaggc                                                   20


<210>  29772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29772
ugcugagccu ggcucugggg                                                   20


<210>  29773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29773
gggcacccuc agguuguguu                                                   20


<210>  29774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29774
cccgauuagg accucgaggc                                                   20


<210>  29775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29775
gagugcgcca gcucugugcc                                                   20


<210>  29776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29776
uugggggcuc ccugccccuc                                                   20


<210>  29777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29777
cugcccacag ucaccucuug                                                   20


<210>  29778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29778
cacccacugu gcccguggcc                                                   20


<210>  29779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29779
gcuuccucua gaugaggaag                                                   20


<210>  29780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29780
ucuagaugag gaaggugccc                                                   20


<210>  29781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29781
ucaucuagag gaagcagaag                                                   20


<210>  29782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29782
uaccuaagca cacccccugg                                                   20


<210>  29783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29783
aucucggggg accccuggcu                                                   20


<210>  29784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29784
uccaucucgg gggaccccug                                                   20


<210>  29785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29785
gcacaugagc ccaugagcua                                                   20


<210>  29786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29786
agccagcugg gguguggacg                                                   20


<210>  29787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29787
ugcugcagga ggcaccuggu                                                   20


<210>  29788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29788
ggcaccaagg acauggggga                                                   20


<210>  29789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29789
guggggagag aucucugcau                                                   20


<210>  29790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29790
gcaugucugu uggcuaucug                                                   20


<210>  29791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29791
cccacacagg cucaguccac                                                   20


<210>  29792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29792
agguggaggg cacugcugcu                                                   20


<210>  29793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29793
cucucugcac cuuggcagca                                                   20


<210>  29794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29794
cagugccaca ccccuucccu                                                   20


<210>  29795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29795
ggaggccagg cccgcaggca                                                   20


<210>  29796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29796
ugccugcggg ccuggccucc                                                   20


<210>  29797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29797
uuccugccug cgggccuggc                                                   20


<210>  29798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29798
ucccuucccu ugacacuaga                                                   20


<210>  29799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29799
cuugacacua gagcaagccc                                                   20


<210>  29800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29800
ucacuugagc agugggggug                                                   20


<210>  29801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29801
caccaaagcc ugcacgcuga                                                   20


<210>  29802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29802
gccugccaag gucacaugca                                                   20


<210>  29803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29803
cugucccuca ccgcagccag                                                   20


<210>  29804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29804
ggccaggaga ggcgaggcag                                                   20


<210>  29805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29805
uggcucccac ccaaggcugg                                                   20


<210>  29806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29806
ccagaguccu gauguguggg                                                   20


<210>  29807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29807
caagugauua aaagguagaa                                                   20


<210>  29808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29808
accuuuuaau cacuugagaa                                                   20


<210>  29809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29809
caaacacuga cgaguuucua                                                   20


<210>  29810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29810
ucacaaacac ugacgaguuu                                                   20


<210>  29811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29811
guucuucaca aacacugacg                                                   20


<210>  29812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29812
cacuucaguu cuucacaaac                                                   20


<210>  29813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29813
cccagaccca ccucgccuug                                                   20


<210>  29814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29814
cugucuccag ccccaccuca                                                   20


<210>  29815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29815
aggccgaggg uggugagggu                                                   20


<210>  29816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29816
agguguggag gcccccgggc                                                   20


<210>  29817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29817
ugagaugggc augggagucg                                                   20


<210>  29818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29818
uggggacaga gacaccaggc                                                   20


<210>  29819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29819
ucucucaggc cuggugucuc                                                   20


<210>  29820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29820
cacaucuccg gaugccccac                                                   20


<210>  29821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29821
cucugaggac agagcuugag                                                   20


<210>  29822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29822
gagagcaagg ccaagcuguu                                                   20


<210>  29823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29823
uaauucccuu uguccguugc                                                   20


<210>  29824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29824
cuuuguccgu ugcacacagc                                                   20


<210>  29825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29825
cagagcggug caggguggag                                                   20


<210>  29826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29826
gggcucagag gccccagggg                                                   20


<210>  29827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29827
gggaacacug cugucuccag                                                   20


<210>  29828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29828
cagaagacgc aguguguucg                                                   20


<210>  29829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29829
cuguuuugca gcgagcagcc                                                   20


<210>  29830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29830
acaccccugg accucugccc                                                   20


<210>  29831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29831
uugaaaaccu cucucauuga                                                   20


<210>  29832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29832
aagaacugga gugcagcacg                                                   20


<210>  29833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29833
cucugagcuc ugaaggaugu                                                   20


<210>  29834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29834
gagcucagag ugaaaaaauu                                                   20


<210>  29835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29835
cugucauguc cauacaugag                                                   20


<210>  29836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29836
cuuggguccu gccaugggcc                                                   20


<210>  29837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29837
gugggacuug gacccguggg                                                   20


<210>  29838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29838
gccaccagca uuaccccaug                                                   20


<210>  29839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29839
gagaagaggg caagguucua                                                   20


<210>  29840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29840
cugaaaucuc caagucaaug                                                   20


<210>  29841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29841
agaugguucc auccucaaag                                                   20


<210>  29842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29842
auccucaaag gaugagggag                                                   20


<210>  29843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29843
auguggaggu gacugcaggu                                                   20


<210>  29844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29844
ugcccugggc ccccgacacu                                                   20


<210>  29845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29845
cuuccugccc ugggcccccg                                                   20


<210>  29846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29846
cuguccacgu ggauggggug                                                   20


<210>  29847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29847
ccacggcgca gcagcgaggu                                                   20


<210>  29848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29848
uugucucagg ccacauucac                                                   20


<210>  29849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29849
ccccuuuggc cugcccuucc                                                   20


<210>  29850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29850
ggaggcugug ggcaccugcg                                                   20


<210>  29851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29851
uuguucccau guuugucucg                                                   20


<210>  29852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29852
cauguuuguc ucgugcugaa                                                   20


<210>  29853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29853
gcacgagaca aacaugggaa                                                   20


<210>  29854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29854
ugucuugaua aaaugucacc                                                   20


<210>  29855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29855
cguggagagg gacaccagga                                                   20


<210>  29856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29856
cuggacaccc ugaguucccg                                                   20


<210>  29857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29857
cccucugcac aguggcagcc                                                   20


<210>  29858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29858
ggucagugga gccauucauu                                                   20


<210>  29859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29859
uucagcucca gcugccuuuc                                                   20


<210>  29860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29860
gcuccagcug ccuuuccugg                                                   20


<210>  29861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29861
uggugugggu agaagcacgg                                                   20


<210>  29862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29862
acccacacca ggaaaggcag                                                   20


<210>  29863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29863
ccauauauag ccgugcuucu                                                   20


<210>  29864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29864
ucaucagaaa ccuggugcau                                                   20


<210>  29865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29865
gaugaugaaa uaaagcaccu                                                   20


<210>  29866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29866
guuuguuuuu uaaacuaugc                                                   20


<210>  29867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29867
gugacuccga gcugcagcac                                                   20


<210>  29868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29868
ugcuuagggg ccggccccca                                                   20


<210>  29869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29869
gcaggaggaa gaaggggagc                                                   20


<210>  29870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29870
uccugcagaa gcugaguuac                                                   20


<210>  29871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29871
uccuccugca gaagcugagu                                                   20


<210>  29872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29872
ccacgugguc cgggcucuuu                                                   20


<210>  29873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29873
ggugagggcg cgggauggug                                                   20


<210>  29874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29874
gcccugguga gccuguggga                                                   20


<210>  29875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29875
cacaggcuca ccagggcaga                                                   20


<210>  29876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29876
cccgcucagg uggcuucggc                                                   20


<210>  29877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29877
gccgagggaa gggggcucac                                                   20


<210>  29878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29878
cucggccgaa gccaccugag                                                   20


<210>  29879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29879
cugcccgugc ugggccuggg                                                   20


<210>  29880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29880
uccucaucgg cuggggacgu                                                   20


<210>  29881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29881
cggcagcaac uuccccgcca                                                   20


<210>  29882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29882
ccgccagggu ggauccgccg                                                   20


<210>  29883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29883
ucaucggccu caccauggcc                                                   20


<210>  29884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29884
ccugcuguag gcugggagcg                                                   20


<210>  29885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29885
uggggauggg gguugcuucc                                                   20


<210>  29886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29886
cugaagcagg ggcguuauuu                                                   20


<210>  29887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29887
gggaagcaac ccccaucccc                                                   20


<210>  29888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29888
gggagacagc aggccgucgc                                                   20


<210>  29889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29889
guaggugggu ccccaucugg                                                   20


<210>  29890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29890
aguucaguag gugggucccc                                                   20


<210>  29891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29891
ucacacacca gcgcuuccag                                                   20


<210>  29892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29892
cgggccugga guacacgcug                                                   20


<210>  29893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29893
uguucucggg ccuggaguac                                                   20


<210>  29894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29894
ucuaccucuu ccuguucucg                                                   20


<210>  29895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29895
cagcacgcgc caccucuccc                                                   20


<210>  29896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29896
cugcuguggu cgccuucuca                                                   20


<210>  29897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29897
ccgggcggcg cccuucccug                                                   20


<210>  29898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29898
cggcugucgc ucguggccag                                                   20


<210>  29899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29899
gugaugcggc ugaucugcuc                                                   20


<210>  29900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29900
auagcgaugu aaagugcccc                                                   20


<210>  29901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29901
ccaggggcag cgucucuggc                                                   20


<210>  29902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29902
ugccagagac gcugccccug                                                   20


<210>  29903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29903
gcuuccugcc agagacgcug                                                   20


<210>  29904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29904
ucuucugcuu ccugccagag                                                   20


<210>  29905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29905
cagccuccga ccugcuguuc                                                   20


<210>  29906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29906
aggggcaggg aggcuccgag                                                   20


<210>  29907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29907
cccugggccc uaugcucgga                                                   20


<210>  29908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29908
cacugggcuu cacccugggc                                                   20


<210>  29909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29909
cuaggcgguc auuggggugg                                                   20


<210>  29910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29910
gggccugggu cucccugugc                                                   20


<210>  29911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29911
cuuugcugau gcccccaauc                                                   20


<210>  29912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29912
uggccuccag gcugauuggg                                                   20


<210>  29913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29913
aagcaucuga gggccacuug                                                   20


<210>  29914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29914
aaauagggca ggguugaggg                                                   20


<210>  29915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29915
cagugccuuc cuaggggcca                                                   20


<210>  29916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29916
uaggggccag gagcagcucc                                                   20


<210>  29917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29917
aggagcugcu ccuggccccu                                                   20


<210>  29918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29918
agagccaggc uuucaaggag                                                   20


<210>  29919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29919
cgggggacca guggcuccug                                                   20


<210>  29920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29920
ccaugggcac ccaggcccag                                                   20


<210>  29921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29921
ugggccuggg ugcccauggg                                                   20


<210>  29922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29922
gugugcgcca cucacugggg                                                   20


<210>  29923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29923
cuguccugca guuucugugu                                                   20


<210>  29924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29924
ucaucucucc auuggggccc                                                   20


<210>  29925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29925
gauccuuccu caucucucca                                                   20


<210>  29926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29926
gggcaugauc ccuugccucc                                                   20


<210>  29927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29927
cacucccugg gcuggcaugu                                                   20


<210>  29928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29928
cgguccuugc cuucccacuc                                                   20


<210>  29929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29929
gagguauggc uggcucugug                                                   20


<210>  29930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29930
ccacuggcau cccgauggcg                                                   20


<210>  29931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29931
ucauccccua ggacccccuc                                                   20


<210>  29932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29932
cgcugcugcu gccccugcug                                                   20


<210>  29933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29933
cggccuccug cuggaccucc                                                   20


<210>  29934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29934
ccgcuaaccc gacccgccgc                                                   20


<210>  29935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29935
ggccugcgcg augcccccgc                                                   20


<210>  29936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29936
gggcgggggc aucgcgcagg                                                   20


<210>  29937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29937
ugcugccugg guucggggcg                                                   20


<210>  29938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29938
gggauugcac aaaaaauagc                                                   20


<210>  29939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29939
cucgcuguua cgagggcgug                                                   20


<210>  29940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29940
aguuuucucu cgcuguuacg                                                   20


<210>  29941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29941
ccgcggcuuc aaguuuucuc                                                   20


<210>  29942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29942
ggccccuggc ccggacucgg                                                   20


<210>  29943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29943
gcgucugugc gaccguccgu                                                   20


<210>  29944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29944
ggggcguggc guggccgggc                                                   20


<210>  29945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29945
cuuccggccg gagucagugg                                                   20


<210>  29946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29946
ggccggaguc aguggcgggg                                                   20


<210>  29947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29947
cgccgguccu gcgggucgcu                                                   20


<210>  29948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29948
gcuccgcuca gggugcugcu                                                   20


<210>  29949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29949
acggggaggg ccaggcccgc                                                   20


<210>  29950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29950
gggccccacg cuggggggcu                                                   20


<210>  29951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29951
gcucgggcug cgugagcuga                                                   20


<210>  29952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29952
ggcucagcac caaacgcagc                                                   20


<210>  29953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29953
cccucagccg ccuguccugg                                                   20


<210>  29954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29954
caccaucuuu cccccucagc                                                   20


<210>  29955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29955
guugucucug cccacccaau                                                   20


<210>  29956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29956
ggugacccag ggagcggggc                                                   20


<210>  29957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29957
gggcgcagaa gcacccgacc                                                   20


<210>  29958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29958
gcgcccggaa agagcgccag                                                   20


<210>  29959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29959
uccagcgugg gucgggugcu                                                   20


<210>  29960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29960
ccugcccaga gggaccguuu                                                   20


<210>  29961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29961
gugagugugc uccagccagg                                                   20


<210>  29962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29962
aaaaugcuug cggaucucac                                                   20


<210>  29963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29963
ccauguguau cugguuaggg                                                   20


<210>  29964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29964
uuuccccaug uguaucuggu                                                   20


<210>  29965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29965
cuauggagua aaggcgguau                                                   20


<210>  29966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29966
aauugugggu aagaacaaag                                                   20


<210>  29967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29967
uacccacaau uggaaguucu                                                   20


<210>  29968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29968
uaauagaugc aguuuuccac                                                   20


<210>  29969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29969
accugcagcc aaaaagacaa                                                   20


<210>  29970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29970
cagaggacag gcaucucuau                                                   20


<210>  29971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29971
uagagaugcc uguccucugg                                                   20


<210>  29972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29972
aaccuccaug cccuccuugu                                                   20


<210>  29973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29973
accugcgugc agcaguaaac                                                   20


<210>  29974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29974
ucccacaguu caaccugcgu                                                   20


<210>  29975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29975
caaaggaaac cuuuccuggg                                                   20


<210>  29976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29976
uuugggaaag ggcuguuauc                                                   20


<210>  29977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29977
uggggauuag ccugcuuuug                                                   20


<210>  29978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29978
aaucuugugg cuaaucuguu                                                   20


<210>  29979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29979
accguaguuu cuaaucuugu                                                   20


<210>  29980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29980
gacccucccc aaacugcucc                                                   20


<210>  29981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29981
ugggugccac aacaucagau                                                   20


<210>  29982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29982
cacugaguca guuccugggu                                                   20


<210>  29983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29983
acucccugug auuucaucuc                                                   20


<210>  29984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29984
ucucugaccu gaccaauggg                                                   20


<210>  29985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29985
gacucacugg cugcccccca                                                   20


<210>  29986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29986
cgcagagcua gcuguguggg                                                   20


<210>  29987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29987
cuguugcaaa ugcccuuucu                                                   20


<210>  29988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29988
ugauaaauug gcugucuagg                                                   20


<210>  29989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29989
cuguuaccua gacagccaau                                                   20


<210>  29990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29990
ccuucccugu uaccuagaca                                                   20


<210>  29991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29991
agcuggauca cgcgcccucu                                                   20


<210>  29992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29992
augacaugac acgcagcuag                                                   20


<210>  29993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29993
guccuggauc gcauagcaag                                                   20


<210>  29994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29994
guccuguucu cguuuccucu                                                   20


<210>  29995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29995
cguuuccucu uugcuuggcc                                                   20


<210>  29996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29996
ucuuugcuug gccaaagagg                                                   20


<210>  29997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29997
ccaagccaag ccuuugcacu                                                   20


<210>  29998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29998
cugccacacg gcuacugcca                                                   20


<210>  29999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  29999
cccaucuaca aauuuucucu                                                   20


<210>  30000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30000
agauuugugg auccgugcac                                                   20


<210>  30001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30001
cccgucaggg ccugagccuc                                                   20


<210>  30002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30002
gcccagcugc caccagcgcu                                                   20


<210>  30003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30003
agagagagac ugacucauuu                                                   20


<210>  30004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30004
agccauggcu ggaccagagc                                                   20


<210>  30005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30005
uguugggagg uguucaagcc                                                   20


<210>  30006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30006
cccuagcauc uucuuccuug                                                   20


<210>  30007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30007
uccuugcuca aagaucccac                                                   20


<210>  30008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30008
uugcucaaag aucccacacc                                                   20


<210>  30009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30009
aacggggugu gggaucuuug                                                   20


<210>  30010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30010
agcuucuaac gggguguggg                                                   20


<210>  30011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30011
ucaccucccc agucguaguc                                                   20


<210>  30012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30012
ggcacguacc agggcagccu                                                   20


<210>  30013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30013
caccucauga gaucacagug                                                   20


<210>  30014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30014
uuccugggau gccggcuaag                                                   20


<210>  30015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30015
ugggaugccg gcuaaggaca                                                   20


<210>  30016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30016
guguuugccc uggcuuguag                                                   20


<210>  30017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30017
ccaggggaug acggagcccc                                                   20


<210>  30018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30018
aaugcgguau gcggucuugc                                                   20


<210>  30019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30019
cuguuccaau gcgguaugcg                                                   20


<210>  30020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30020
gcaccucccu cagcaaggug                                                   20


<210>  30021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30021
ucguggugca aggcuuguug                                                   20


<210>  30022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30022
ggauauggcu cccuggccag                                                   20


<210>  30023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30023
caagcuggcc agggagccau                                                   20


<210>  30024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30024
aggggcucgu uacuucuuac                                                   20


<210>  30025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30025
uacagcucac agucccuccc                                                   20


<210>  30026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30026
ccugcacuaa ucaagaggga                                                   20


<210>  30027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30027
gauucugacc ugaaacugca                                                   20


<210>  30028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30028
gaccugaaac ugcaucccag                                                   20


<210>  30029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30029
ggucagaauc agaagaugug                                                   20


<210>  30030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30030
ggacacugca cucucggagg                                                   20


<210>  30031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30031
ccauucagga cacugcacuc                                                   20


<210>  30032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30032
gggugcuggg guucuccauu                                                   20


<210>  30033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30033
guggaugcuu cugggugcug                                                   20


<210>  30034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30034
agcagaggga cuguggguga                                                   20


<210>  30035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30035
cuucucugau uucuaaaaua                                                   20


<210>  30036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30036
cugauuucua aaauaucugc                                                   20


<210>  30037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30037
aaaauaucug caaacuuguu                                                   20


<210>  30038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30038
uuuauaauug aaaauauaau                                                   20


<210>  30039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30039
auuauaaaug aaacaaguuu                                                   20


<210>  30040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30040
acacaugaag gcaaacgucc                                                   20


<210>  30041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30041
uguguagaau uuacuguugu                                                   20


<210>  30042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30042
gucaaccacg gacguuugcc                                                   20


<210>  30043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30043
ggccagugua auuucuguca                                                   20


<210>  30044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30044
cugcgucugg acaagccuca                                                   20


<210>  30045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30045
cgaucccaga ggugcauuuc                                                   20


<210>  30046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30046
ggauucauuc uauuucauca                                                   20


<210>  30047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30047
uucuauuuca ucaggugacg                                                   20


<210>  30048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30048
auuucaucag gugacguuuu                                                   20


<210>  30049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30049
ucaggugacg uuuuaacaga                                                   20


<210>  30050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30050
guuaaaacgu caccugauga                                                   20


<210>  30051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30051
aaccuccagc uccccccacc                                                   20


<210>  30052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30052
gguuguagcc ucgaguuugg                                                   20


<210>  30053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30053
uuaacagugg cuuucugguu                                                   20


<210>  30054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30054
cuccguaguc aucugcucaa                                                   20


<210>  30055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30055
gcaguugagc agaugacuac                                                   20


<210>  30056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30056
caccccggcu ggucaaagug                                                   20


<210>  30057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30057
gugggacagg cuugcucuuc                                                   20


<210>  30058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30058
cacaggucag cggccggcag                                                   20


<210>  30059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30059
ggcuuuccau uucggucagu                                                   20


<210>  30060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30060
auuucgguca gugugcucug                                                   20


<210>  30061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30061
gucagugugc ucugacacag                                                   20


<210>  30062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30062
ggagcugugu cagagcacac                                                   20


<210>  30063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30063
uguuuuucag gagcuguguc                                                   20


<210>  30064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30064
guggugucaa ggcagcguga                                                   20


<210>  30065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30065
ggcugugcca ggacuugagc                                                   20


<210>  30066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30066
uuccggcugu gccaggacuu                                                   20


<210>  30067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30067
ugaagaggga gggccguggg                                                   20


<210>  30068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30068
agaagacagu ggcuuuacuu                                                   20


<210>  30069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30069
gagagugcuc ucaggggcca                                                   20


<210>  30070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30070
ggcugugagg agcacaggcu                                                   20


<210>  30071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30071
guugacguuu cuggcuguga                                                   20


<210>  30072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30072
cagacaaacu uggcacgaaa                                                   20


<210>  30073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30073
ugccaaguuu gucugggaaa                                                   20


<210>  30074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30074
cuucauauuu gugauuuugc                                                   20


<210>  30075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30075
uauuugugau uuugcaaaga                                                   20


<210>  30076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30076
cggccacuag ggugcucugc                                                   20


<210>  30077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30077
acgccaucau ggggccucuc                                                   20


<210>  30078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30078
gcagggccag gcccacagcc                                                   20


<210>  30079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30079
acagaggcca aucacauccg                                                   20


<210>  30080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30080
gaguucuucc caagcgcucu                                                   20


<210>  30081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30081
ucccaagcgc ucugaaaggg                                                   20


<210>  30082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30082
caagcgcucu gaaagggugc                                                   20


<210>  30083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30083
gagcgcuugg gaagaacucg                                                   20


<210>  30084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30084
acucuggugc acccuuucag                                                   20


<210>  30085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30085
gguuccacuc uggugcaccc                                                   20


<210>  30086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30086
aagugcgaca ggacagagau                                                   20


<210>  30087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30087
ggccaucucu guccugucgc                                                   20


<210>  30088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30088
uacaaauaug uuauacuuua                                                   20


<210>  30089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30089
uuacauagca acuccaaaca                                                   20


<210>  30090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30090
ugggauucuu uacauagcaa                                                   20


<210>  30091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30091
ucuugggauu cuuuacauag                                                   20


<210>  30092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30092
uggaguaugu ggcuuugucc                                                   20


<210>  30093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30093
ugugcugccu guuccuggag                                                   20


<210>  30094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30094
ccacguccug gagggacagg                                                   20


<210>  30095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30095
agugccccau ccugucccuc                                                   20


<210>  30096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30096
uuuccagugc cccauccugu                                                   20


<210>  30097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30097
cuccacaugc ggcagggguc                                                   20


<210>  30098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30098
ggcacccagu ggugaccccu                                                   20


<210>  30099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30099
gacuucuggc acccaguggu                                                   20


<210>  30100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30100
aacuuccgac uucuggcacc                                                   20


<210>  30101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30101
aauaaaugag cuggaaagaa                                                   20


<210>  30102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30102
agcucauuua uuugaaaauc                                                   20


<210>  30103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30103
uuccagcuca uuuauuugaa                                                   20


<210>  30104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30104
uuaaccugug guaacacuuu                                                   20


<210>  30105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30105
guggcagggg cagugccuag                                                   20


<210>  30106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30106
gucuaggcac ugccccugcc                                                   20


<210>  30107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30107
uccaucucau gcaucgcauc                                                   20


<210>  30108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30108
aucucaugca ucgcaucucg                                                   20


<210>  30109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30109
ccgagaugcg augcaugaga                                                   20


<210>  30110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30110
ggaaacaucu ggcaaagaug                                                   20


<210>  30111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30111
ugaaucugca agugacgcua                                                   20


<210>  30112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30112
gcuuaacagg cacuuauauc                                                   20


<210>  30113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30113
cuccugacuu uacauuucug                                                   20


<210>  30114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30114
uaucuaaagu cauucucucc                                                   20


<210>  30115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30115
aaaagaaagc caaacaguuu                                                   20


<210>  30116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30116
uuuggaauac guuggcgauu                                                   20


<210>  30117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30117
gcaggaacau gaauugggaa                                                   20


<210>  30118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30118
ugcagaaacu guuuggcuuu                                                   20


<210>  30119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30119
uguuccugca gaaacuguuu                                                   20


<210>  30120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30120
caauucaugu uccugcagaa                                                   20


<210>  30121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30121
aauuuugcuu uguuuccuuc                                                   20


<210>  30122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30122
uucugcgaga cucggguggu                                                   20


<210>  30123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30123
gcgagacucg ggugguugca                                                   20


<210>  30124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30124
gaauucucuc caccaccaaa                                                   20


<210>  30125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30125
gaagugcaac cacccgaguc                                                   20


<210>  30126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30126
cuccaccacc aaaagcugcu                                                   20


<210>  30127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30127
aucgaucuuc cuaacaacag                                                   20


<210>  30128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30128
uaacaacaga gaucucaguu                                                   20


<210>  30129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30129
ucauaggauu caggggcuau                                                   20


<210>  30130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30130
ggggcuauca aaaacacaaa                                                   20


<210>  30131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30131
gugagcugag auugcaccac                                                   20


<210>  30132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30132
gccuccuggg uucaagagau                                                   20


<210>  30133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30133
agagauucuc cugccccagc                                                   20


<210>  30134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30134
ccugccccag ccugcugagu                                                   20


<210>  30135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30135
gggauaaccu uuaugaccug                                                   20


<210>  30136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30136
ucagguucug ggauaaccuu                                                   20


<210>  30137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30137
caggugggca agugcgcggg                                                   20


<210>  30138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30138
agcucuuucc uugccgcuua                                                   20


<210>  30139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30139
uugccgcuua ucaacccuuu                                                   20


<210>  30140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30140
cguuuucuuc cucacucucc                                                   20


<210>  30141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30141
uccucacucu ccacguugga                                                   20


<210>  30142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30142
ucacucucca cguuggauuc                                                   20


<210>  30143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30143
agguccaagu ggcuaucugg                                                   20


<210>  30144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30144
ggcggggagg acacagagga                                                   20


<210>  30145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30145
uccucguugc ucucaggguc                                                   20


<210>  30146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30146
ucguugcucu cagggucacu                                                   20


<210>  30147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30147
uugcuuugcu cuuccuggac                                                   20


<210>  30148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30148
uggacaucuu ccucgacauu                                                   20


<210>  30149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30149
ucgacauuca ucuuuccauc                                                   20


<210>  30150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30150
ucuuuccauc cuaccaagag                                                   20


<210>  30151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30151
auccuaccaa gagcguggaa                                                   20


<210>  30152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30152
acgcucuugg uaggauggaa                                                   20


<210>  30153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30153
cucucuuuuu uuaauuuaaa                                                   20


<210>  30154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30154
cuuucucucu cuuuuuuuaa                                                   20


<210>  30155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30155
uuuucucuuu cucucucuuu                                                   20


<210>  30156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30156
uacaaaguaa gauguuugcc                                                   20


<210>  30157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30157
ugcuagauaa agaugacagg                                                   20


<210>  30158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30158
gaucaucugc ugacauaugu                                                   20


<210>  30159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30159
uaacauuuuc auccucaucc                                                   20


<210>  30160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30160
uccucauccu uuccaagcau                                                   20


<210>  30161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30161
aagcauucuu cgaagucucu                                                   20


<210>  30162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30162
ucgaagucuc ucagccugag                                                   20


<210>  30163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30163
aagucucuca gccugagcag                                                   20


<210>  30164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30164
aagaaugcuu ggaaaggaug                                                   20


<210>  30165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30165
ugcucaggcu gagagacuuc                                                   20


<210>  30166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30166
uuccugcuca ggcugagaga                                                   20


<210>  30167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30167
ugaggugcuc cugcucuucc                                                   20


<210>  30168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30168
uuugccaauu cugccuccgu                                                   20


<210>  30169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30169
gccuccgucu ucauccuguu                                                   20


<210>  30170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30170
uccuguuaga gggcugcgcc                                                   20


<210>  30171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30171
uuucaaagcc aagcucgcga                                                   20


<210>  30172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30172
aagccaagcu cgcgaaccau                                                   20


<210>  30173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30173
cgagcuuggc uuugaaauga                                                   20


<210>  30174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30174
accuuagccc gaugcauaug                                                   20


<210>  30175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30175
uucuaccuua gcccgaugca                                                   20


<210>  30176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30176
ucuuucuacc uuagcccgau                                                   20


<210>  30177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30177
ucauuuuaaa aauauauuua                                                   20


<210>  30178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30178
uuuuaaaaau auauuuauuu                                                   20


<210>  30179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30179
cucacugagc uugggugacc                                                   20


<210>  30180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30180
guacuuggcu cccaccuugg                                                   20


<210>  30181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30181
uuuuugucuc uguucucuga                                                   20


<210>  30182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30182
cugacuuggg aguuuugugg                                                   20


<210>  30183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30183
gacucuccug ucccacaaaa                                                   20


<210>  30184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30184
uuccagucuu ggucuagcuu                                                   20


<210>  30185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30185
agucuugguc uagcuucucc                                                   20


<210>  30186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30186
ccgugagcuc gagggcaucu                                                   20


<210>  30187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30187
cguugagcuu gucucucccu                                                   20


<210>  30188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30188
ccagagggag agacaagcuc                                                   20


<210>  30189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30189
uacucacaau aaaugcuuuu                                                   20


<210>  30190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30190
guaaaagcau uuauugugag                                                   20


<210>  30191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30191
ccacgguaag acaggcucac                                                   20


<210>  30192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30192
ugaucaucuu cuccacggua                                                   20


<210>  30193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30193
cuuguuuuga cuuggcaaug                                                   20


<210>  30194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30194
aucagcucuu uccgggacuu                                                   20


<210>  30195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30195
gggacuucgg uuucucccgc                                                   20


<210>  30196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30196
guuucucccg cuccucgccu                                                   20


<210>  30197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30197
cccgcuccuc gccuuccugu                                                   20


<210>  30198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30198
uguugagucu ucuugugaag                                                   20


<210>  30199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30199
ugugaaggag cccaccgccu                                                   20


<210>  30200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30200
caagaagacu caacaggaag                                                   20


<210>  30201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30201
gccuuuugcc cccagcugag                                                   20


<210>  30202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30202
cugugggguu uucugccuuu                                                   20


<210>  30203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30203
gaagaugcug gaaaugggac                                                   20


<210>  30204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30204
gaacaaaggu guacaaaucu                                                   20


<210>  30205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30205
agcaucuuca gaacaaaggu                                                   20


<210>  30206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30206
cugagcucau ggguagaacg                                                   20


<210>  30207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30207
acccaugagc ucagagaaau                                                   20


<210>  30208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30208
aauaaaauaa uggauaucaa                                                   20


<210>  30209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30209
ucgauccuca gcaucgcugu                                                   20


<210>  30210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30210
cgaugucugc caaagacugg                                                   20


<210>  30211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30211
ucaucuucau uuagauugua                                                   20


<210>  30212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30212
ucuucauuua gauuguagau                                                   20


<210>  30213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30213
uuuagauugu agaugcuuuu                                                   20


<210>  30214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30214
caugaugucg cugacagaag                                                   20


<210>  30215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30215
gucagcgaca ucaugagaaa                                                   20


<210>  30216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30216
cuucugucag cgacaucaug                                                   20


<210>  30217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30217
uaaaauuacc acuuccauuu                                                   20


<210>  30218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30218
uuccauaccu gcuguuccag                                                   20


<210>  30219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30219
auaccugcug uuccagagca                                                   20


<210>  30220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30220
agagcaaacc ucuucaucau                                                   20


<210>  30221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30221
ucaucuucuc cucggggcuc                                                   20


<210>  30222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30222
ccucggggcu cauguugcug                                                   20


<210>  30223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30223
ccgaagcguu uaucucugaa                                                   20


<210>  30224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30224
gagaauacaa cagcaacaug                                                   20


<210>  30225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30225
gagauaaacg cuucggagaa                                                   20


<210>  30226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30226
uuguacucuu uuaguaaagu                                                   20


<210>  30227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30227
agcguacaca gacuuuacua                                                   20


<210>  30228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30228
gaccuguuuu ccagcguaca                                                   20


<210>  30229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30229
ugugauuucc acuacagggg                                                   20


<210>  30230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30230
aaguuggcug uccuggaggu                                                   20


<210>  30231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30231
accuccagga cagccaacuu                                                   20


<210>  30232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30232
cuaaagaaag cugugagagg                                                   20


<210>  30233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30233
uuagggaauu caaccuccag                                                   20


<210>  30234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30234
ucacccaucu cuguccucuc                                                   20


<210>  30235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30235
ucgagcagua caggcuagca                                                   20


<210>  30236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30236
agcaggaagg ggguagaugg                                                   20


<210>  30237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30237
ugcuagaagc cagugacacu                                                   20


<210>  30238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30238
cauuaucugg aauaugauuc                                                   20


<210>  30239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30239
agauaaugag aacuaauauu                                                   20


<210>  30240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30240
acauuauugu gauucucuuu                                                   20


<210>  30241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30241
cuuucuuucu uaaacuauau                                                   20


<210>  30242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30242
uucuuaaacu auauagaugu                                                   20


<210>  30243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30243
uaaacuauau agauguugug                                                   20


<210>  30244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30244
auaugauguc acaacaucua                                                   20


<210>  30245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30245
uaaaucagua acuauauuaa                                                   20


<210>  30246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30246
ggcuccccgu gcgccccccg                                                   20


<210>  30247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30247
ugagggcccg ugcgcgagac                                                   20


<210>  30248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30248
ggcccaggau cuggaacuuc                                                   20


<210>  30249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30249
agauccuggg ccggaagacg                                                   20


<210>  30250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30250
gccuguuaac uuucaccucg                                                   20


<210>  30251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30251
ccucgaacgg auuggaguug                                                   20


<210>  30252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30252
aggugaaagu uaacaggcag                                                   20


<210>  30253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30253
ccgggccccc ucgcgcuccc                                                   20


<210>  30254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30254
uucgcgcccc gaccuucuuc                                                   20


<210>  30255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30255
cgccccgacc uucuucgccu                                                   20


<210>  30256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30256
ucgccuucgc cauggcgcgc                                                   20


<210>  30257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30257
ccuucgccau ggcgcgcgcc                                                   20


<210>  30258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30258
ccauggcgcg cgccccgcug                                                   20


<210>  30259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30259
gcggcccggc acgugucuua                                                   20


<210>  30260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30260
ucgucucgcg agaacagcgc                                                   20


<210>  30261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30261
cgcgagacga ggaagcgguu                                                   20


<210>  30262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30262
cgcgagucgg aggugcugcg                                                   20


<210>  30263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30263
gggagcugua gugccccggc                                                   20


<210>  30264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30264
gcuaagccgu uagcgccgag                                                   20


<210>  30265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30265
uggccccauc gcccucgccu                                                   20


<210>  30266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30266
ucuuggcccc aucgcccucg                                                   20


<210>  30267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30267
gcgagaccga ggagacugag                                                   20


<210>  30268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30268
cgagcuccau guccuggcgc                                                   20


<210>  30269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30269
gcagcagcga guuggccacg                                                   20


<210>  30270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30270
cuaaccauua aucaagcuau                                                   20


<210>  30271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30271
acuucucuaa ccauuaauca                                                   20


<210>  30272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30272
agacuagccu gggcaacaua                                                   20


<210>  30273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30273
gccucccaaa gugcugggau                                                   20


<210>  30274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30274
aauaucugac agauaagaaa                                                   20


<210>  30275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30275
cugccaacaa aagguuaccc                                                   20


<210>  30276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30276
cuaagcaaua augucuaccg                                                   20


<210>  30277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30277
uuuggccagg cgcgguggcu                                                   20


<210>  30278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30278
ugagcuuuau auuuugaccc                                                   20


<210>  30279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30279
uuaagguaac uauugccuaa                                                   20


<210>  30280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30280
agaguuuuuu gaggagcuuu                                                   20


<210>  30281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30281
uaaguuacuu uuuagcagaa                                                   20


<210>  30282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30282
gcuaaaaagu aacuuaagaa                                                   20


<210>  30283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30283
gucuccagua aauauguggu                                                   20


<210>  30284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30284
aaaguacaaa uuaauagucu                                                   20


<210>  30285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30285
ucaugcuugu uucagcaccu                                                   20


<210>  30286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30286
ugcuuguuuc agcaccuuuu                                                   20


<210>  30287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30287
ucauccuuau ucauucauuc                                                   20


<210>  30288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30288
uuuccucauc cuuauucauu                                                   20


<210>  30289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30289
gauccaggca uaccuaccgu                                                   20


<210>  30290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30290
gcuucagauc caggcauacc                                                   20


<210>  30291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30291
auuuuugggc cacuucugcu                                                   20


<210>  30292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30292
uuccauuuuu gggccacuuc                                                   20


<210>  30293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30293
uuuccuucca uuuuugggcc                                                   20


<210>  30294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30294
ugccaaguuu cuuuuccuuc                                                   20


<210>  30295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30295
ugcuauuccu gccaaguuuc                                                   20


<210>  30296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30296
uccugcuauu ccugccaagu                                                   20


<210>  30297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30297
ucuuccugcu auuccugcca                                                   20


<210>  30298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30298
auuuuuauaa ggauaccaau                                                   20


<210>  30299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30299
ccaguuagcc ccuaacccuc                                                   20


<210>  30300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30300
uucauucauu caacaaauau                                                   20


<210>  30301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30301
uacauucauu cauucauuca                                                   20


<210>  30302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30302
guuucacuca aaaacgguuu                                                   20


<210>  30303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30303
cucaaaaacg guuuauugug                                                   20


<210>  30304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30304
ucccuguauc ccuagagcca                                                   20


<210>  30305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30305
ucuguuuuua uucaucccug                                                   20


<210>  30306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30306
gagaagcuga cagucaugga                                                   20


<210>  30307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30307
cagaaggaga uauucaucug                                                   20


<210>  30308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30308
cugugucugc uugcuucagc                                                   20


<210>  30309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30309
gcccuuuucu gccuauaaaa                                                   20


<210>  30310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30310
gccuauaaaa ccaaacuccu                                                   20


<210>  30311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30311
augagcuaaa cagaggaguu                                                   20


<210>  30312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30312
uucucuuucu cucuuucuuu                                                   20


<210>  30313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30313
cuuucucucu uucuuucucu                                                   20


<210>  30314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30314
cucuuucuuu cucucucuuu                                                   20


<210>  30315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30315
uucucucucu uucccucccu                                                   20


<210>  30316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30316
cucucuuucc cucccuccuc                                                   20


<210>  30317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30317
uuuuuacagc uaaaauugag                                                   20


<210>  30318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30318
caauuuuagc uguaaaaaag                                                   20


<210>  30319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30319
auaaaaccua guuuauucuc                                                   20


<210>  30320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30320
uaaaagucag uugcuguauu                                                   20


<210>  30321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30321
cacucaauau ggaucuuuag                                                   20


<210>  30322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30322
ucccacucaa uauggaucuu                                                   20


<210>  30323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30323
cuuuuucuuc ccacucaaua                                                   20


<210>  30324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30324
ucuuuaaaau uacuuuaugu                                                   20


<210>  30325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30325
ggugcaccug uggcucgcca                                                   20


<210>  30326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30326
ccuuuucggg ugcaccugug                                                   20


<210>  30327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30327
uuuccccuuu ucgggugcac                                                   20


<210>  30328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30328
ucuuccuuuc cccuuuucgg                                                   20


<210>  30329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30329
cauaagcugc uuggaaacag                                                   20


<210>  30330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30330
aagcagcuua ugugaaccuc                                                   20


<210>  30331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30331
uggacucaag agauccagcu                                                   20


<210>  30332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30332
gcauucuagc cugggugaca                                                   20


<210>  30333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30333
agccugggug acagagcaag                                                   20


<210>  30334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30334
uuuuugagau agggucuugc                                                   20


<210>  30335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30335
gggguauuug cacauugaga                                                   20


<210>  30336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30336
acccacuugg ccuggcaggc                                                   20


<210>  30337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30337
cuacuggucc agaucccaug                                                   20


<210>  30338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30338
uccuggacau gggacaagaa                                                   20


<210>  30339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30339
ugcuuacccu ccaguugucu                                                   20


<210>  30340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30340
gcaggcagau caucccaucg                                                   20


<210>  30341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30341
gcagacugga gugagaacuu                                                   20


<210>  30342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30342
gucuaucccu ggcuugaagg                                                   20


<210>  30343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30343
agccagggau agacugaagc                                                   20


<210>  30344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30344
cuggggaccc ugccccuuuc                                                   20


<210>  30345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30345
acccaggagc cugucugccu                                                   20


<210>  30346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30346
gcucagugca ggccagggca                                                   20


<210>  30347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30347
cuaucucugc uuucucuugu                                                   20


<210>  30348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30348
uauuucacua ucucugcuuu                                                   20


<210>  30349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30349
cugcucaaug auucagcagc                                                   20


<210>  30350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30350
gcagcuuggg cacagaagca                                                   20


<210>  30351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30351
gugcccaagc ugcugaauca                                                   20


<210>  30352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30352
guggugcuuc ugugcccaag                                                   20


<210>  30353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30353
acuuguggaa ucuagagggc                                                   20


<210>  30354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30354
acaaguggaa aacaagcaug                                                   20


<210>  30355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30355
cccuagacuc auaaucuucc                                                   20


<210>  30356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30356
acauguucac ccuagacuca                                                   20


<210>  30357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30357
gggcugcuua uaaguauuua                                                   20


<210>  30358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30358
aaaucuguaa acaagaucua                                                   20


<210>  30359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30359
aaauggcaga gcuagugaca                                                   20


<210>  30360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30360
ugauagguac ccaaaccacu                                                   20


<210>  30361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30361
guuugagugg uuuggguacc                                                   20


<210>  30362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30362
accaauauau cuuaacauuu                                                   20


<210>  30363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30363
uuuaacaguc agaaauaucc                                                   20


<210>  30364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30364
cccaaauuca ggaggauaug                                                   20


<210>  30365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30365
ggaggauaug gcaaaaaaag                                                   20


<210>  30366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30366
auuuuuuacu acgaccacuu                                                   20


<210>  30367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30367
auuggugagu aaauagugcc                                                   20


<210>  30368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30368
ugauuccucu caggaaaaaa                                                   20


<210>  30369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30369
ucucaggaaa aaaaauccuu                                                   20


<210>  30370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30370
ugagaggaau caugaagaua                                                   20


<210>  30371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30371
gaucugcagu uauaaaguug                                                   20


<210>  30372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30372
uuaaaaauau auauuuuuua                                                   20


<210>  30373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30373
acagacaaua auuggcucgg                                                   20


<210>  30374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30374
ucuacagaca auaauuggcu                                                   20


<210>  30375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30375
agacaguuuu cuaugcacgu                                                   20


<210>  30376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30376
augcacguuu uaaaaaauua                                                   20


<210>  30377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30377
uuuaguacua uuguaguucc                                                   20


<210>  30378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30378
uuuuaaagaa agaugaugaa                                                   20


<210>  30379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30379
uuaaaaggaa cuacaauagu                                                   20


<210>  30380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30380
ucaucuuucu uuaaaaggaa                                                   20


<210>  30381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30381
ggugguauaa aggagcuagu                                                   20


<210>  30382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30382
cuaaaaguuu acaaaugacc                                                   20


<210>  30383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30383
aaucuuuuau ccguuuuaaa                                                   20


<210>  30384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30384
uucuauguuc uagauauuag                                                   20


<210>  30385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30385
auguucuaga uauuagaugc                                                   20


<210>  30386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30386
agauauuaga ugcuuaacag                                                   20


<210>  30387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30387
ccugcuuauc uguuaagcau                                                   20


<210>  30388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30388
ggcgauucuc cugcuuaucu                                                   20


<210>  30389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30389
cacucgauac aguaaaaguc                                                   20


<210>  30390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30390
aagccuuaca guucucacuc                                                   20


<210>  30391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30391
auuuguuugc uucuuauccc                                                   20


<210>  30392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30392
uaucccuuug cuucacccag                                                   20


<210>  30393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30393
cccagaaaag gauuauagca                                                   20


<210>  30394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30394
gggugaagca aagggauaag                                                   20


<210>  30395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30395
uaucgguugc uugucacaaa                                                   20


<210>  30396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30396
ggcaguucug ugauaccaaa                                                   20


<210>  30397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30397
gugauaccaa acccacucua                                                   20


<210>  30398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30398
augugccucu uuagaguggg                                                   20


<210>  30399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30399
uggaugcagu ggugagcagu                                                   20


<210>  30400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30400
aaagcauaag auuggguggu                                                   20


<210>  30401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30401
aaaaugcugg gauuacagca                                                   20


<210>  30402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30402
cuguguuggu caggaugguc                                                   20


<210>  30403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30403
ccugccucag ccucccaagu                                                   20


<210>  30404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30404
agugauuccc cugccucagc                                                   20


<210>  30405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30405
ugcucauuaa augaauuagu                                                   20


<210>  30406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30406
uuuaaugagc aagaaauagg                                                   20


<210>  30407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30407
accagagaac uagaacccau                                                   20


<210>  30408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30408
cugguugaau ccugacugau                                                   20


<210>  30409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30409
gccugaggac ggcagcuuca                                                   20


<210>  30410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30410
uccuccagga agacucaucu                                                   20


<210>  30411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30411
uccaggaaga cucaucucug                                                   20


<210>  30412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30412
uggaggaaga aauucugccu                                                   20


<210>  30413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30413
uaacaccuuc caacugauua                                                   20


<210>  30414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30414
aacugauuag gucagagcca                                                   20


<210>  30415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30415
ccaacaaugu uucauuaugu                                                   20


<210>  30416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30416
ucaccaacaa uguuucauua                                                   20


<210>  30417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30417
aggccagccu gagcaacaua                                                   20


<210>  30418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30418
uucuuuucuu ccaucucucc                                                   20


<210>  30419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30419
uuucuuccau cucuccaauc                                                   20


<210>  30420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30420
uccaucucuc caaucaggca                                                   20


<210>  30421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30421
aucucuccaa ucaggcagaa                                                   20


<210>  30422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30422
gccugauugg agagauggaa                                                   20


<210>  30423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30423
uauucugccu gauuggagag                                                   20


<210>  30424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30424
guccucauca ucggcaacuu                                                   20


<210>  30425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30425
ucaaugauaa gguguguuuu                                                   20


<210>  30426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30426
augauaaggu guguuuucuu                                                   20


<210>  30427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30427
ucuuuagaau aaaaauuugu                                                   20


<210>  30428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30428
uuagaauaaa aauuuguaga                                                   20


<210>  30429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30429
aaagaagaaa acacaccuua                                                   20


<210>  30430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30430
ggaggcugag gaaggaggau                                                   20


<210>  30431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30431
ucagccuccc gaagugcugg                                                   20


<210>  30432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30432
agaucagcau ggccaacaua                                                   20


<210>  30433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30433
ucuuuugcau uuuguuugau                                                   20


<210>  30434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30434
ucaugacauc aaacaaaaug                                                   20


<210>  30435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30435
aagagaucua auuguuaguu                                                   20


<210>  30436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30436
guguauuuaa aguuucagaa                                                   20


<210>  30437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30437
gaauauagag uuggagaauu                                                   20


<210>  30438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30438
gaaacuuuaa auacacugaa                                                   20


<210>  30439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30439
ccaacucuau auucugaaac                                                   20


<210>  30440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30440
uaaaagcuuu aaugggucuu                                                   20


<210>  30441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30441
ucacccaggu auuaagcuua                                                   20


<210>  30442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30442
agguguuguu gaccuaaaau                                                   20


<210>  30443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30443
uuuuagguca acaacaccuu                                                   20


<210>  30444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30444
ucauuuuagg ucaacaacac                                                   20


<210>  30445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30445
uaguuuuccu cucaggguuc                                                   20


<210>  30446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30446
ucucaggguu cucaaauauu                                                   20


<210>  30447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30447
caaauauuaa aauucagcca                                                   20


<210>  30448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30448
gccaaauuug aauuuauggu                                                   20


<210>  30449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30449
aauuuggcug aauuuuaaua                                                   20


<210>  30450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30450
uuuaaaccau aaauucaaau                                                   20


<210>  30451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30451
gauacugaac caauuuugua                                                   20


<210>  30452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30452
auuaauaugg uguauuauag                                                   20


<210>  30453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30453
uagauaucau uuaucaggcu                                                   20


<210>  30454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30454
cauuuaagua ugauguuggc                                                   20


<210>  30455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30455
ccuguaauuc cagcacuuug                                                   20


<210>  30456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30456
uauauauuag caauuaaaau                                                   20


<210>  30457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30457
uuuuuuuugg auuuuaauug                                                   20


<210>  30458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30458
uaauuucuuu uuuuuuggau                                                   20


<210>  30459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30459
cuuuguauag uaucaaaaaa                                                   20


<210>  30460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30460
uuuuugauac uauacaaagg                                                   20


<210>  30461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30461
uaaguauuuu auucuuuuuu                                                   20


<210>  30462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30462
uucuuaagua uuuuauucuu                                                   20


<210>  30463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30463
ugagaucuuc uuuaauuuuu                                                   20


<210>  30464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30464
auuucuugag aucuucuuua                                                   20


<210>  30465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30465
uggaucagaa gacuuaauau                                                   20


<210>  30466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30466
gauccacgaa caggagaugu                                                   20


<210>  30467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30467
aaacuuagua caaagcuaca                                                   20


<210>  30468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30468
aucaagaccg uuuaaugauu                                                   20


<210>  30469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30469
gaaaaauuga gacuuuggag                                                   20


<210>  30470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30470
gaaacuaaau agcagguuga                                                   20


<210>  30471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30471
ccauguuggc caggcugguc                                                   20


<210>  30472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30472
agaccagccu ggccaacaug                                                   20


<210>  30473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30473
gaauuuccuu uuuuuaaaag                                                   20


<210>  30474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30474
gaaauacgcu acaacuugga                                                   20


<210>  30475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30475
uuuuuuuaaa aggcugaaua                                                   20


<210>  30476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30476
gccuuuuaaa aaaaggaaau                                                   20


<210>  30477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30477
acuguguaua uauacugcau                                                   20


<210>  30478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30478
uccacagaca ccuggguugu                                                   20


<210>  30479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30479
ccauagcaaa aaacaaccca                                                   20


<210>  30480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30480
uugcagcaua auucaccaua                                                   20


<210>  30481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30481
auucugugug uguguuuuuu                                                   20


<210>  30482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30482
gugugugugu uuuuuuguuu                                                   20


<210>  30483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30483
ccauguuggc uggucucaaa                                                   20


<210>  30484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30484
ggugauccac ccaccucggc                                                   20


<210>  30485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30485
guucacuagu aaguuaugaa                                                   20


<210>  30486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30486
cuaguaaguu augaaaucac                                                   20


<210>  30487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30487
uaacuuacua gugaacagaa                                                   20


<210>  30488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30488
gguaaagggg cugccaacuu                                                   20


<210>  30489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30489
gucacaacau cuggagguau                                                   20


<210>  30490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30490
gucccaaucu acauucuguc                                                   20


<210>  30491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30491
ccuccuucag ucccaaucua                                                   20


<210>  30492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30492
aaaaaagccu uugaggaaug                                                   20


<210>  30493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30493
ucaaaggcuu uuuuggaagg                                                   20


<210>  30494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30494
ugcugagccc ugcauauauu                                                   20


<210>  30495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30495
uccgcuguga caugagugac                                                   20


<210>  30496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30496
cauggcuccc ugggccuccg                                                   20


<210>  30497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30497
uugcucugag agcaagcaga                                                   20


<210>  30498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30498
cugcacacug aggagcuggg                                                   20


<210>  30499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30499
uuuagugaga auucagcggc                                                   20


<210>  30500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30500
cacuaaagga auaagcaucu                                                   20


<210>  30501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30501
gcggccaguu ccacacccca                                                   20


<210>  30502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30502
acaccccaca gauaaauggc                                                   20


<210>  30503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30503
uguuggauau ucacauuaau                                                   20


<210>  30504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30504
cauuaauggu auucuagugu                                                   20


<210>  30505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30505
aguguuugug auuugaacug                                                   20


<210>  30506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30506
aaucacaaac acuagaauac                                                   20


<210>  30507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30507
aaaaagaugu cucuggcugg                                                   20


<210>  30508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30508
uaucacaaua ucccaggacc                                                   20


<210>  30509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30509
uccugucuuc aucugggaug                                                   20


<210>  30510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30510
ugucuucauc ugggaugcca                                                   20


<210>  30511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30511
ucugggaugc cacagaggcc                                                   20


<210>  30512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30512
uggccucugu ggcaucccag                                                   20


<210>  30513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30513
guccacgcuu uuguccuuca                                                   20


<210>  30514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30514
caucccucuc cugggcaugu                                                   20


<210>  30515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30515
guaaaacaga gauaauaauc                                                   20


<210>  30516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30516
ccuucuguaa aacagagaua                                                   20


<210>  30517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30517
guuaucaagc agcaugcuuc                                                   20


<210>  30518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30518
ugggagugag ggugucagcu                                                   20


<210>  30519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30519
cuucuuggga gugagggugu                                                   20


<210>  30520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30520
auuucacugc uuuuuucauu                                                   20


<210>  30521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30521
cugcuuuuuu cauucauucu                                                   20


<210>  30522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30522
uucauucuau uucacuucug                                                   20


<210>  30523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30523
uucuauuuca cuucuguuuu                                                   20


<210>  30524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30524
auuucacuuc uguuuucacu                                                   20


<210>  30525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30525
cuucuguuuu cacuuauagc                                                   20


<210>  30526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30526
guuuucacuu auagcguuag                                                   20


<210>  30527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30527
cuuauagcgu uagaaccuaa                                                   20


<210>  30528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30528
agaguugccc auaacuaccu                                                   20


<210>  30529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30529
ccucuuaggu aguuaugggc                                                   20


<210>  30530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30530
aaugguuccc cucuuaggua                                                   20


<210>  30531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30531
ucaaaugguu ccccucuuag                                                   20


<210>  30532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30532
ugguauucuu caaaugguuc                                                   20


<210>  30533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30533
caguuuuuac aauggaaaug                                                   20


<210>  30534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30534
auuguaaaaa cugagaaaaa                                                   20


<210>  30535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30535
agccauuucc auuguaaaaa                                                   20


<210>  30536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30536
gccucagccu ccugaguagc                                                   20


<210>  30537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30537
aggcuauagu acgggaugau                                                   20


<210>  30538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30538
ucuaauuuaa uagacucugu                                                   20


<210>  30539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30539
aauuuaauag acucuguucu                                                   20


<210>  30540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30540
cucuuuuuaa aauggcaggu                                                   20


<210>  30541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30541
guggcuagaa aauaaaacuu                                                   20


<210>  30542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30542
agccacugaa ccaacaggga                                                   20


<210>  30543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30543
uuuuucaaag gauggcacaa                                                   20


<210>  30544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30544
aaggauggca caacguauau                                                   20


<210>  30545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30545
ugccucagcc ucccgaguag                                                   20


<210>  30546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30546
ucuuuuuuuu uuuuuuuuuu                                                   20


<210>  30547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30547
gcucaaaggg gaugcccggg                                                   20


<210>  30548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30548
auaaaugagg cgaagacaag                                                   20


<210>  30549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30549
ccucauuuau ugaaccauuc                                                   20


<210>  30550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30550
uuuuuaaaag aacaaugcaa                                                   20


<210>  30551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30551
uuuaaaaaag aaaaguuuac                                                   20


<210>  30552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30552
ggucucacau ugcauuguuc                                                   20


<210>  30553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30553
cauugauuag gcaacccgua                                                   20


<210>  30554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30554
uuguuacggg uugccuaauc                                                   20


<210>  30555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30555
aggaaaaggc ggauuuggag                                                   20


<210>  30556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30556
uagaacucug uaaugucuaa                                                   20


<210>  30557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30557
uagcagcgcu gcuagcuggg                                                   20


<210>  30558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30558
caggaccuug cuccccaccc                                                   20


<210>  30559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30559
gguaaugcau cagcucuccc                                                   20


<210>  30560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30560
caaaacaccc acuaaggcaa                                                   20


<210>  30561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30561
cacaguuggc aaagauuauu                                                   20


<210>  30562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30562
auguggauuc ucacaguugg                                                   20


<210>  30563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30563
uaaaaaccuu uugcucaaaa                                                   20


<210>  30564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30564
cuuggugacu ucaccuuuua                                                   20


<210>  30565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30565
ccuuuuaccu cauaguucug                                                   20


<210>  30566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30566
gaagaagcug guuuccaugc                                                   20


<210>  30567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30567
gaacuaugag guaaaaggug                                                   20


<210>  30568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30568
ucagaacuau gagguaaaag                                                   20


<210>  30569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30569
augcuugaug ccccagcuca                                                   20


<210>  30570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30570
aucugggcaa agugacugag                                                   20


<210>  30571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30571
guuuccgcau uguggaauuu                                                   20


<210>  30572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30572
gcauugugga auuuccauga                                                   20


<210>  30573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30573
acaaugcgga aacagaaucg                                                   20


<210>  30574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30574
augauucuau uuccauacau                                                   20


<210>  30575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30575
auuuccauac auuuaagacu                                                   20


<210>  30576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30576
auacauuuaa gacugguccc                                                   20


<210>  30577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30577
cauaguacag agugaauuag                                                   20


<210>  30578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30578
cucuguacua ugugaauuug                                                   20


<210>  30579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30579
aaacaccuuu ugauguaggu                                                   20


<210>  30580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30580
caaauugaca cauuuccaaa                                                   20


<210>  30581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30581
uuaggauuuu cccaaauuga                                                   20


<210>  30582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30582
cucuuguugc cuagacugga                                                   20


<210>  30583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30583
agcgauucuc cugccucagc                                                   20


<210>  30584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30584
ccugccucag ccucccgagu                                                   20


<210>  30585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30585
uauuuuuagu agagaggggg                                                   20


<210>  30586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30586
ccauguuggu cagggugguc                                                   20


<210>  30587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30587
agaccacccu gaccaacaug                                                   20


<210>  30588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30588
ccauccacca acuacagugg                                                   20


<210>  30589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30589
ggucugggga uuuaaagaga                                                   20


<210>  30590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30590
agaacuuuua agucccuaag                                                   20


<210>  30591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30591
ugaacuccau augaucacuc                                                   20


<210>  30592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30592
aaggaaaagc cacuagcauu                                                   20


<210>  30593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30593
uuugaauugu aauaugggag                                                   20


<210>  30594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30594
aggcaaugcu aguggcuuuu                                                   20


<210>  30595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30595
aauuaacuuc aaggcaaugc                                                   20


<210>  30596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30596
ugucauguca agcugcaggu                                                   20


<210>  30597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30597
ggagaaguaa caguacuguc                                                   20


<210>  30598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30598
ccugaaguaa caacuacguu                                                   20


<210>  30599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30599
agagaccaug aagaauauuu                                                   20


<210>  30600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30600
uggucucugg aacuguacca                                                   20


<210>  30601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30601
ucauggucuc uggaacugua                                                   20


<210>  30602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30602
guaagaaauc cacccucugu                                                   20


<210>  30603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30603
uacagaaaua ucuaucaugg                                                   20


<210>  30604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30604
aacagagggu ggauuucuua                                                   20


<210>  30605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30605
aggacauauu caaacagagg                                                   20


<210>  30606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30606
uguucuagga cauauucaaa                                                   20


<210>  30607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30607
uacuuggacu cuugcuaauc                                                   20


<210>  30608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30608
caaaaucuga gucauuacau                                                   20


<210>  30609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30609
uucacaaaau cugagucauu                                                   20


<210>  30610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30610
ucuguucuuu cacaaaaucu                                                   20


<210>  30611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30611
ggaacauggg ucauguguuu                                                   20


<210>  30612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30612
agaaauuuuu ccucuguucu                                                   20


<210>  30613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30613
uuuguaaaca caugacccau                                                   20


<210>  30614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30614
uuccuuugua aacacaugac                                                   20


<210>  30615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30615
caauagcuaa aauuugcuaa                                                   20


<210>  30616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30616
ggaggccaag guaggcagau                                                   20


<210>  30617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30617
gggcucaagc gaucugccua                                                   20


<210>  30618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30618
agaucagccu aggcaacaug                                                   20


<210>  30619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30619
uuuuuaaugu auuuauuuau                                                   20


<210>  30620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30620
uaucuucuuu uuuaauguau                                                   20


<210>  30621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30621
caaacaaaug auuggcugca                                                   20


<210>  30622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30622
ugcagccaau cauuuguuug                                                   20


<210>  30623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30623
cacagacuug cucuggaggu                                                   20


<210>  30624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30624
gaguaggggu gagcugacug                                                   20


<210>  30625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30625
gacaggcauu cagaguaggg                                                   20


<210>  30626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30626
aaucgugcau uugcuuuuuc                                                   20


<210>  30627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30627
aagugcuagc acuuccucca                                                   20


<210>  30628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30628
uccagugggc uugagagagc                                                   20


<210>  30629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30629
uucgcuuaug cuugaagucc                                                   20


<210>  30630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30630
cuuaugcuug aaguccuccg                                                   20


<210>  30631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30631
agcauaagcg aaagaauuac                                                   20


<210>  30632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30632
gaggacuuca agcauaagcg                                                   20


<210>  30633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30633
uuucggagga cuucaagcau                                                   20


<210>  30634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30634
uuuaccauug ugcucacuca                                                   20


<210>  30635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30635
acuacagucu guggccuaaa                                                   20


<210>  30636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30636
gacgugggca gacccgaggu                                                   20


<210>  30637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30637
agcagcguga ucuugggccc                                                   20


<210>  30638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30638
cugcuagaga ugagaucacg                                                   20


<210>  30639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30639
cacccagcuc ucagcacagu                                                   20


<210>  30640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30640
auucccuuuc ucugauuugc                                                   20


<210>  30641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30641
cuuucucuga uuugcccauu                                                   20


<210>  30642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30642
cugauuugcc cauuccacuu                                                   20


<210>  30643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30643
aagauaauga cuguuaauau                                                   20


<210>  30644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30644
aauauuuucc acaauuaacu                                                   20


<210>  30645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30645
acaauuaacu uuguauuucu                                                   20


<210>  30646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30646
uuuguguggc cuaagaaaug                                                   20


<210>  30647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30647
uaggccacac aaaggaagcu                                                   20


<210>  30648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30648
uguggcucgc acuugacagg                                                   20


<210>  30649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30649
uuuuuuuugu agcuuuuugc                                                   20


<210>  30650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30650
uuauucuuuu uuuuuguagc                                                   20


<210>  30651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30651
ucuucuuuau ucuuuuuuuu                                                   20


<210>  30652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30652
ccuuuccucu ucuuuauucu                                                   20


<210>  30653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30653
cauuuagagc cauagcuuca                                                   20


<210>  30654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30654
uuucucauuu agagccauag                                                   20


<210>  30655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30655
ggagaaagug caaaguagau                                                   20


<210>  30656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30656
ccagaauucu uuucucauuu                                                   20


<210>  30657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30657
uaguaagugu cuccucuuag                                                   20


<210>  30658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30658
cugugcauug uuugauucau                                                   20


<210>  30659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30659
uagcacuuuu gucagccgac                                                   20


<210>  30660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30660
gugagcguga gcugagcggc                                                   20


<210>  30661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30661
acggcuucag ugagcgugag                                                   20


<210>  30662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30662
uguuuucuga guuuaugugg                                                   20


<210>  30663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30663
gaguuuaugu ggggguuugc                                                   20


<210>  30664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30664
uucuuauuca aaccuuagaa                                                   20


<210>  30665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30665
uauucaaacc uuagaaaaca                                                   20


<210>  30666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30666
aaccuuagaa aacauagaag                                                   20


<210>  30667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30667
aagguuugaa uaagaaagaa                                                   20


<210>  30668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30668
auguuuucua agguuugaau                                                   20


<210>  30669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30669
aacuucuggu uuguuauaaa                                                   20


<210>  30670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30670
gguuuguuau aaaucuguag                                                   20


<210>  30671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30671
gucacucuuc acaccugcca                                                   20


<210>  30672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30672
caccugccag cuugcagagg                                                   20


<210>  30673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30673
uggugaauug cccuuuccuu                                                   20


<210>  30674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30674
ccaagaaaca cggguaacua                                                   20


<210>  30675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30675
uuucccuuau cacagccagc                                                   20


<210>  30676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30676
cuuaucacag ccagccagag                                                   20


<210>  30677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30677
cuggccccug ggacacugug                                                   20


<210>  30678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30678
cucucucucu cucuuuuuuu                                                   20


<210>  30679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30679
cucuguuguc caggcuggag                                                   20


<210>  30680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30680
aggcccaagu gauccuccua                                                   20


<210>  30681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30681
uccaagccau uuauuucuua                                                   20


<210>  30682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30682
uagcccggag guuagcugcu                                                   20


<210>  30683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30683
gaguagcugg gacuacaguc                                                   20


<210>  30684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30684
agcaauccuc ccaccacagc                                                   20


<210>  30685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30685
uuugcuuaaa ugcuuugauu                                                   20


<210>  30686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30686
auaucguugg ccucucccaa                                                   20


<210>  30687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30687
uugggagagg ccaacgauau                                                   20


<210>  30688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30688
acaucugcuu aauauauauu                                                   20


<210>  30689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30689
uucaacaucu gcuuaauaua                                                   20


<210>  30690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30690
caagaggaga gaaaguaagg                                                   20


<210>  30691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30691
cuccucuugu gaauauucau                                                   20


<210>  30692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30692
agggccagug agaauuccuu                                                   20


<210>  30693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30693
cacuggcccu ugaauuagua                                                   20


<210>  30694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30694
uugugguuua auucuguggu                                                   20


<210>  30695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30695
cagcaccucu guuacuguuu                                                   20


<210>  30696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30696
aggaaugaaa aucaaauaau                                                   20


<210>  30697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30697
uggaauaaau ccaacuuggu                                                   20


<210>  30698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30698
uuccuggaau aaauccaacu                                                   20


<210>  30699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30699
cauuuaauca cuugguuaaa                                                   20


<210>  30700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30700
aauuguuagu ggcugauuca                                                   20


<210>  30701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30701
auuuucuaau uguuaguggc                                                   20


<210>  30702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30702
ugaugccauu guaaauggua                                                   20


<210>  30703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30703
ccugccucag ccucccgagu                                                   20


<210>  30704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30704
agcgauucuc cugccucagc                                                   20


<210>  30705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30705
uguucuguuu uuaugauguu                                                   20


<210>  30706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30706
guuuuuauga uguugcuguc                                                   20


<210>  30707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30707
uaagcguagg cuaaacuaac                                                   20


<210>  30708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30708
uaauggugag caccaagcac                                                   20


<210>  30709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30709
aauccccucc auucauaaug                                                   20


<210>  30710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30710
cauuuacaac cugggcaauc                                                   20


<210>  30711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30711
augcugcaga gcuguguugc                                                   20


<210>  30712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30712
aagccgcaac acagcucugc                                                   20


<210>  30713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30713
cucuguaaau cuuccaagcc                                                   20


<210>  30714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30714
uucccucugu aaaucuucca                                                   20


<210>  30715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30715
uaccuguaua caauucuuuc                                                   20


<210>  30716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30716
cccagcccua ggcuucccug                                                   20


<210>  30717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30717
cugguucaca cuggcugcuu                                                   20


<210>  30718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30718
cacuggcugc uuccaggaug                                                   20


<210>  30719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30719
aggaugggca ggagaauagc                                                   20


<210>  30720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30720
ccugcccauc cuggaagcag                                                   20


<210>  30721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30721
uaggguuggu cacuuacacu                                                   20


<210>  30722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30722
aauaguguaa gugaccaacc                                                   20


<210>  30723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30723
auauaaccua cacacauccu                                                   20


<210>  30724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30724
cuuggauauc aaaauccaag                                                   20


<210>  30725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30725
uuguaccuuu gcacaaggug                                                   20


<210>  30726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30726
ugugugggug ccacucucca                                                   20


<210>  30727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30727
ugucauucug agagacuccu                                                   20


<210>  30728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30728
gagagacucc ugcucauccg                                                   20


<210>  30729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30729
ugggaguccu ugaucucauu                                                   20


<210>  30730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30730
uccuauucug auggaccuuu                                                   20


<210>  30731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30731
uauucugaug gaccuuuggc                                                   20


<210>  30732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30732
gauggaccuu uggcuucucc                                                   20


<210>  30733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30733
ccuuaucuua uauaucccac                                                   20


<210>  30734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30734
ucaacucagg cgaccaccuc                                                   20


<210>  30735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30735
augguccaau accaccagac                                                   20


<210>  30736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30736
uuuguuacuc cuggaguaaa                                                   20


<210>  30737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30737
caggugacua cggcugagcc                                                   20


<210>  30738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30738
gucucaagau gagcuggauu                                                   20


<210>  30739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30739
caugugagcu uuggcucauc                                                   20


<210>  30740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30740
acaaaugcuu agugauaccu                                                   20


<210>  30741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30741
uucaacaaau gcuuagugau                                                   20


<210>  30742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30742
caccucagcc cccugaguag                                                   20


<210>  30743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30743
aauaugggga auuuucaguu                                                   20


<210>  30744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30744
ccauauuaga augccucaag                                                   20


<210>  30745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30745
guuuuugaaa cacuuaaaaa                                                   20


<210>  30746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30746
aaaacugaaa auuccccaua                                                   20


<210>  30747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30747
cuuaccauua acauauuuuu                                                   20


<210>  30748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30748
uuaaggacug uuugcuuucc                                                   20


<210>  30749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30749
uuccuacugg gcugcauauu                                                   20


<210>  30750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30750
uacugggcug cauauuuaau                                                   20


<210>  30751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30751
gugauuaaau augcagccca                                                   20


<210>  30752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30752
aaucuguaua acuaugcaaa                                                   20


<210>  30753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30753
uugcauaguu auacagauuu                                                   20


<210>  30754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30754
uuuuacacug ucgucacaug                                                   20


<210>  30755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30755
ucucagcaaa caacucacau                                                   20


<210>  30756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30756
uguccugccu guuugccgug                                                   20


<210>  30757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30757
ugagccacgg caaacaggca                                                   20


<210>  30758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30758
uguuuugccg cgcuagcccu                                                   20


<210>  30759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30759
uacuggguac ucaggaauca                                                   20


<210>  30760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30760
ugaguaccca guaggaacaa                                                   20


<210>  30761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30761
gaauaauugg gccuuuuguu                                                   20


<210>  30762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30762
gaaguuggca cugugauucc                                                   20


<210>  30763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30763
uguagagacu ugaagccuga                                                   20


<210>  30764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30764
agucucuaca agaaacaaca                                                   20


<210>  30765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30765
caggcuucaa gucucuacaa                                                   20


<210>  30766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30766
ccuugaugau cgugguaagu                                                   20


<210>  30767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30767
caucuaaugg guagacuuug                                                   20


<210>  30768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30768
guauccaagu cccucuaaca                                                   20


<210>  30769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30769
gcauccaacu uucuguaucc                                                   20


<210>  30770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30770
cuccuaauca uuaaguccac                                                   20


<210>  30771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30771
auucucuccu aaucauuaag                                                   20


<210>  30772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30772
uuuuguuauu guuuccauuc                                                   20


<210>  30773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30773
uuuuaaaaag augaaauacu                                                   20


<210>  30774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30774
ucuuuuuaaa augaacacau                                                   20


<210>  30775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30775
ccuguguuua ggcaagaagc                                                   20


<210>  30776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30776
ugccuaaaca caggggaaug                                                   20


<210>  30777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30777
auuaaugauu gaguuuuaga                                                   20


<210>  30778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30778
aaaacucaau cauuaauuga                                                   20


<210>  30779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30779
aggcugcagu gagcuaugau                                                   20


<210>  30780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30780
gcauagcugg gacuacagcu                                                   20


<210>  30781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30781
caaacuacug cccucaagca                                                   20


<210>  30782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30782
cucccaaagc acuaggguua                                                   20


<210>  30783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30783
agguggggca caguggcuua                                                   20


<210>  30784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30784
gacuuugugu uuacuuuaau                                                   20


<210>  30785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30785
cccucuuguu ucuugcuguu                                                   20


<210>  30786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30786
ugcuguugac ccaccucuug                                                   20


<210>  30787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30787
uuuuuauuuc cauuccccuc                                                   20


<210>  30788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30788
auuccccucu aaacuuuguc                                                   20


<210>  30789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30789
ccucuaaacu uugucauguu                                                   20


<210>  30790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30790
gcaggcuccu ugucugcagc                                                   20


<210>  30791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30791
ucuaagggag agucauaccc                                                   20


<210>  30792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30792
ggguaugacu cucccuuaga                                                   20


<210>  30793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30793
uucaagugag uuuucuuggc                                                   20


<210>  30794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30794
agugaguuuu cuuggcaaag                                                   20


<210>  30795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30795
uggcaaagaa gggucuuaca                                                   20


<210>  30796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30796
uugccaagaa aacucacuug                                                   20


<210>  30797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30797
cggcaggagc cacugaccuu                                                   20


<210>  30798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30798
aaguccccca cgacugcccu                                                   20


<210>  30799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30799
ugcuuaucua auucauguau                                                   20


<210>  30800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30800
uguaugacac ccugcccugu                                                   20


<210>  30801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30801
ucacagggca gggugucaua                                                   20


<210>  30802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30802
aguacccucc uuccucacag                                                   20


<210>  30803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30803
cauuuaaugg aaggcgauac                                                   20


<210>  30804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30804
auuaaaugag aauuccagua                                                   20


<210>  30805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30805
uaaaucuugg uaucgccuuc                                                   20


<210>  30806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30806
uuccuggugc ugugcugcuc                                                   20


<210>  30807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30807
uggugcugug cugcucacca                                                   20


<210>  30808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30808
cuuagugccc uccccaccca                                                   20


<210>  30809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30809
accuacccuu guuaagccuu                                                   20


<210>  30810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30810
gaucaaccac auagcuugga                                                   20


<210>  30811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30811
cugcuuuguu uacacaaaag                                                   20


<210>  30812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30812
uuauguuuau gagcaagcac                                                   20


<210>  30813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30813
caugauuguc ccuuuauguu                                                   20


<210>  30814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30814
aaccauuucu caugauuguc                                                   20


<210>  30815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30815
guguuuuuag gagauuuuuc                                                   20


<210>  30816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30816
guguaguucu cucuucuuua                                                   20


<210>  30817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30817
cucuucuuua gaacuuuacc                                                   20


<210>  30818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30818
uuagaacuuu accccacaug                                                   20


<210>  30819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30819
aaagaagaga gaacuacaca                                                   20


<210>  30820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30820
ccagugcuaa cuccugccug                                                   20


<210>  30821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30821
ccuccugcgc cacgaucuga                                                   20


<210>  30822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30822
gaucguggcg caggagggga                                                   20


<210>  30823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30823
cugucucuuc ucuuggggac                                                   20


<210>  30824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30824
cuuggggacc acaguccucu                                                   20


<210>  30825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30825
uuuuuuuaaa guucuuuuua                                                   20


<210>  30826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30826
uuuuaagguc agggucucuc                                                   20


<210>  30827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30827
gguuguaauu gugccacaau                                                   20


<210>  30828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30828
ggcaugcacc accacaucca                                                   20


<210>  30829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30829
cagcuacuca ggaggcugag                                                   20


<210>  30830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30830
agaccagccu ggccaacaug                                                   20


<210>  30831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30831
ccauguuggc caggcugguc                                                   20


<210>  30832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30832
ccugccucgg ccuccugagu                                                   20


<210>  30833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30833
agcgauucuc cugccucggc                                                   20


<210>  30834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30834
uugcaguucu uuuagucauu                                                   20


<210>  30835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30835
uuuagucauu agcaaaaguu                                                   20


<210>  30836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30836
uugguucuag gguuguucac                                                   20


<210>  30837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30837
aggguuguuc acucaaauua                                                   20


<210>  30838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30838
cucaaauuaa uuuaaaguca                                                   20


<210>  30839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30839
ggugauccac cugccuuggc                                                   20


<210>  30840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30840
agaccagccu ggccaacaug                                                   20


<210>  30841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30841
ccauguuggc caggcugguc                                                   20


<210>  30842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30842
gccucagccc cucaaguagc                                                   20


<210>  30843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30843
ucugccucag ccccucaagu                                                   20


<210>  30844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30844
agcgauucuu cugccucagc                                                   20


<210>  30845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30845
gcucacugca accuccgccu                                                   20


<210>  30846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30846
cuucugugcg guuaaaccac                                                   20


<210>  30847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30847
gugcgguuaa accaccagcu                                                   20


<210>  30848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30848
uuuucuuaau uuugcuuuca                                                   20


<210>  30849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30849
uaauuuugcu uucaauuuuu                                                   20


<210>  30850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30850
auuuuuagcg aucuaauuuu                                                   20


<210>  30851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30851
ugccauucuc cugccucagc                                                   20


<210>  30852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30852
ccugccucag ccucccaagc                                                   20


<210>  30853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30853
ccguguuagc caggaugguc                                                   20


<210>  30854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30854
aaagauaaca ccgcaaaaua                                                   20


<210>  30855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30855
aucccugacc auccccaagu                                                   20


<210>  30856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30856
uuccuucauu uacauacuau                                                   20


<210>  30857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30857
uucauuuaca uacuauauau                                                   20


<210>  30858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30858
uuuacauacu auauauguau                                                   20


<210>  30859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30859
ccacucauuu cuuaaauaaa                                                   20


<210>  30860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30860
uaaauaaagu aguagaccac                                                   20


<210>  30861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30861
cugaauauac gguggagaug                                                   20


<210>  30862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30862
gugaaauagc cacguggagg                                                   20


<210>  30863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30863
guccgucugc ugugccuccu                                                   20


<210>  30864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30864
ccugcaggag gcacagcaga                                                   20


<210>  30865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30865
guuggugccg cgauggagag                                                   20


<210>  30866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30866
uauuucguug aauguauccu                                                   20


<210>  30867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30867
uugaauguau ccuugauaga                                                   20


<210>  30868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30868
acgaaauagg aaauuacaug                                                   20


<210>  30869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30869
aggacucuau caaggauaca                                                   20


<210>  30870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30870
cccacuucua ggacucuauc                                                   20


<210>  30871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30871
uacgcaauuu gucagauauu                                                   20


<210>  30872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30872
gcuccagggu guuucccguc                                                   20


<210>  30873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30873
cgucugcauu cccaccagca                                                   20


<210>  30874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30874
caccagcagu gcacgagagc                                                   20


<210>  30875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30875
ccacagccuc gccagcagac                                                   20


<210>  30876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30876
cgaacuuugg aguuuuuguc                                                   20


<210>  30877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30877
agaacucggu cugcuggcga                                                   20


<210>  30878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30878
cagcuaacaa acugacaaaa                                                   20


<210>  30879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30879
guguaguuuu aaguugcauu                                                   20


<210>  30880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30880
caguuuaaaa auccauuuuu                                                   20


<210>  30881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30881
uauaaaaaug gauuuuuaaa                                                   20


<210>  30882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30882
uaucauuguc uuauuuuucu                                                   20


<210>  30883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30883
uuuaaguaga gugcuaacau                                                   20


<210>  30884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30884
uguauuuuuc auuuaaguag                                                   20


<210>  30885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30885
agaccagccu gggcaacaug                                                   20


<210>  30886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30886
uuuguagaga caggguuugg                                                   20


<210>  30887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30887
uuucuuuugu agagacaggg                                                   20


<210>  30888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30888
uuucuuuucu uuuguagaga                                                   20


<210>  30889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30889
uuuucuuuuc uuuucuuuug                                                   20


<210>  30890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30890
auaauccaca uuucauuuuc                                                   20


<210>  30891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30891
uucaauaauc cacauuucau                                                   20


<210>  30892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30892
uccccuugua cagaugcauu                                                   20


<210>  30893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30893
ucucuaaagc aucaugcaga                                                   20


<210>  30894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30894
uucauuucac caauaaauau                                                   20


<210>  30895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30895
uuucaccaau aaauauuuau                                                   20


<210>  30896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30896
ccaauaaaua uuuauugagc                                                   20


<210>  30897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30897
aauaucauac ccuggccuac                                                   20


<210>  30898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30898
ccacuuaucc ucagcuucua                                                   20


<210>  30899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30899
acuuauucac cacuuauccu                                                   20


<210>  30900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30900
agggcuggcu aaucuuucua                                                   20


<210>  30901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30901
acacacucaa cagaauguuu                                                   20


<210>  30902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30902
guugagugug uagaaagauu                                                   20


<210>  30903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30903
auaauuucgu auuuucuuua                                                   20


<210>  30904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30904
uauuuucuuu auaauuuuuu                                                   20


<210>  30905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30905
uuauaauuuu uuugagacag                                                   20


<210>  30906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30906
cacucuugcc cugcaguggu                                                   20


<210>  30907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30907
ccgcagccuc gaccuucugg                                                   20


<210>  30908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30908
gggcuuaagc gauccuccug                                                   20


<210>  30909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30909
caggcugguc ucaaaaugug                                                   20


<210>  30910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30910
acauuuugag accagccugg                                                   20


<210>  30911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30911
agcacuuugg gaggccaagg                                                   20


<210>  30912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30912
caccuguaau uccagcacuu                                                   20


<210>  30913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30913
auaggaauuc aacaaauauu                                                   20


<210>  30914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30914
uauggaacua acaaauuagg                                                   20


<210>  30915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30915
acaaauauuu aaauccuucu                                                   20


<210>  30916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30916
auauucaacg cauuaacaca                                                   20


<210>  30917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30917
acgcauuaac acauaauaua                                                   20


<210>  30918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30918
cuaaguaccu uaauuuuguu                                                   20


<210>  30919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30919
cugacucuau uaccauuugu                                                   20


<210>  30920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30920
caagagaaua acuccauauc                                                   20


<210>  30921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30921
cuugagaaca aaugguaaua                                                   20


<210>  30922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30922
uguguagcug ucccugugua                                                   20


<210>  30923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30923
gucagaguac caguacuaua                                                   20


<210>  30924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30924
guaguugaua uaauauucau                                                   20


<210>  30925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30925
uuauauuuuu auugauguac                                                   20


<210>  30926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30926
agguacauca auaaaaauau                                                   20


<210>  30927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30927
gucuuaucaa gugguggccu                                                   20


<210>  30928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30928
ugaucaauag ccaggcaaaa                                                   20


<210>  30929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30929
auuuuugccu ggcuauugau                                                   20


<210>  30930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30930
ugcugcuagu gaaaaugcau                                                   20


<210>  30931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30931
cuagcagcag gaaaauucga                                                   20


<210>  30932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30932
auacaaugca uuuucacuag                                                   20


<210>  30933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30933
uguuuaguaa aauuccauac                                                   20


<210>  30934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30934
agaguaugaa augcuauuau                                                   20


<210>  30935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30935
uacucuggaa caguaaacgu                                                   20


<210>  30936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30936
agccaugguu uuugaggggc                                                   20


<210>  30937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30937
cauuuuaauu guuguuacgg                                                   20


<210>  30938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30938
cccgugaccu guguaauaac                                                   20


<210>  30939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30939
aauauguuau uacacagguc                                                   20


<210>  30940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30940
gaccucgguu uggccacaga                                                   20


<210>  30941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30941
gggaucucug uggccaaacc                                                   20


<210>  30942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30942
aggaagaguu ggaacagucg                                                   20


<210>  30943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30943
ucgaacccuc uguccuucug                                                   20


<210>  30944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30944
aacucuuccu cgaacccucu                                                   20


<210>  30945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30945
ugagaggcuu ucggcguccu                                                   20


<210>  30946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30946
gcguccuugu ccuuucuauc                                                   20


<210>  30947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30947
auccgggugc cugagugccu                                                   20


<210>  30948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30948
gaggcacuca ggcacccgga                                                   20


<210>  30949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30949
cuguguucug aggcacucag                                                   20


<210>  30950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30950
ggguggauuu cucuguguuc                                                   20


<210>  30951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30951
aaacaccacu gcgccaucua                                                   20


<210>  30952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30952
uacagaugag gggugaggcc                                                   20


<210>  30953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30953
cugagugacc ucaggacuca                                                   20


<210>  30954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30954
gcccucacuu cgcugaguga                                                   20


<210>  30955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30955
ugaggcuccg agaggccgug                                                   20


<210>  30956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30956
aaagauccgg gggcagugcc                                                   20


<210>  30957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30957
ugcaggacuc ugcgaggcuc                                                   20


<210>  30958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30958
gcucuugcgu cuuguggggu                                                   20


<210>  30959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30959
cugcccuggg auagauggca                                                   20


<210>  30960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30960
ggagguggag ccuucccuag                                                   20


<210>  30961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30961
cuagaccacc auuucccuug                                                   20


<210>  30962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30962
cuugugaaug ugacucugug                                                   20


<210>  30963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30963
caagggaaau gguggucuag                                                   20


<210>  30964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30964
gcucaucuug gaugaaucau                                                   20


<210>  30965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30965
uccaagauga gcugaauugc                                                   20


<210>  30966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30966
uauaucauca aguccaccag                                                   20


<210>  30967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30967
aacuggugga cuugaugaua                                                   20


<210>  30968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30968
cagagucaug caaccaucac                                                   20


<210>  30969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30969
caacuuuuuu uuuuuuuuga                                                   20


<210>  30970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30970
agccugggcg acugagugag                                                   20


<210>  30971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30971
ccugccucag cuuccugagu                                                   20


<210>  30972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30972
ugaguaucug gaacuacagg                                                   20


<210>  30973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30973
agauacucag gaagcugagg                                                   20


<210>  30974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30974
ccauguuguc caggcugguc                                                   20


<210>  30975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30975
ccucccaaaa ugcugggauu                                                   20


<210>  30976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30976
uccauguugu cacacacguu                                                   20


<210>  30977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30977
acguguguga caacauggac                                                   20


<210>  30978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30978
caguaacaca guauacauuc                                                   20


<210>  30979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30979
uauaauuccc aguaacacag                                                   20


<210>  30980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30980
auuuccugua uuuguuaugu                                                   20


<210>  30981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30981
uguauuuguu auguagcacc                                                   20


<210>  30982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30982
ggugcuacau aacaaauaca                                                   20


<210>  30983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30983
uuauugacaa cuucaggugc                                                   20


<210>  30984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30984
uagaucagac agccaagucc                                                   20


<210>  30985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30985
gggacauucu ccauucaaaa                                                   20


<210>  30986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30986
ccauucaaaa aauacaaaga                                                   20


<210>  30987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30987
aaaaauacaa agagaaaguc                                                   20


<210>  30988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30988
cuuuguauuu uuugaaugga                                                   20


<210>  30989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30989
uugaucgacc uccucccauu                                                   20


<210>  30990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30990
ugauucuuug aucgaccucc                                                   20


<210>  30991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30991
gagaaguuuu cagaggaugc                                                   20


<210>  30992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30992
cagaauacuc cucgguauca                                                   20


<210>  30993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30993
gaggaugcca aaucuaucug                                                   20


<210>  30994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30994
cagccucuac agagccugac                                                   20


<210>  30995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30995
cacucauucu aguuguuuuc                                                   20


<210>  30996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30996
aguuguuuuc acuggcagcu                                                   20


<210>  30997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30997
cuggcagcua uaacaaaaaa                                                   20


<210>  30998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30998
gcaaguccug gucacccacc                                                   20


<210>  30999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  30999
ggaggcucgg guccaccugu                                                   20


<210>  31000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31000
ggaggcucag guccaccugu                                                   20


<210>  31001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31001
ggaggcucag guccaccugc                                                   20


<210>  31002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31002
uaagcaaacg uguccucccu                                                   20


<210>  31003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31003
ccaugcuccu gccacuggga                                                   20


<210>  31004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31004
ucagacaaaa agagccagug                                                   20


<210>  31005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31005
cacuggcucu uuuugucuga                                                   20


<210>  31006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31006
agacaugauc uggaaaugac                                                   20


<210>  31007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31007
agaucauguc uggaaacuuu                                                   20


<210>  31008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31008
ugguuugauu ucucaaauaa                                                   20


<210>  31009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31009
caaauaaugc uacugaaagg                                                   20


<210>  31010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31010
guagcauuau uugagaaauc                                                   20


<210>  31011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31011
cuuucaguag cauuauuuga                                                   20


<210>  31012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31012
guuuucagaa aauagccaag                                                   20


<210>  31013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31013
gaaaauagcc aagccuuguu                                                   20


<210>  31014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31014
gaaaacugaa uuaauaaccu                                                   20


<210>  31015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31015
uugaccaauu uuauaugaag                                                   20


<210>  31016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31016
uauaaaauug gucaaugaaa                                                   20


<210>  31017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31017
uguauuuuga gguggguaag                                                   20


<210>  31018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31018
gugugccugg cucugggccu                                                   20


<210>  31019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31019
uuaacugugc uaagggccuc                                                   20


<210>  31020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31020
gggaccaggg accaggucuc                                                   20


<210>  31021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31021
cucacugauu gagugucugg                                                   20


<210>  31022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31022
uuuauuuuca uucaacaagg                                                   20


<210>  31023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31023
uucaacaagg auuuauugag                                                   20


<210>  31024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31024
acaaggauuu auugagcauc                                                   20


<210>  31025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31025
aggcaccguc cuaggcauug                                                   20


<210>  31026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31026
cccaaugccu aggacggugc                                                   20


<210>  31027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31027
auuugcugcu guuuccccca                                                   20


<210>  31028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31028
guucuauuug cugcuguuuc                                                   20


<210>  31029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31029
cgcuggcagg gcggggacuu                                                   20


<210>  31030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31030
ugucaguucu cgcuggcagg                                                   20


<210>  31031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31031
guuuccuguc aguucucgcu                                                   20


<210>  31032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31032
ccguccucca gagugcgggu                                                   20


<210>  31033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31033
ugcucucugu cccguccccc                                                   20


<210>  31034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31034
gcauggccug ggcuuccugc                                                   20


<210>  31035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31035
ucugauggcc augaagccau                                                   20


<210>  31036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31036
uggccaucag aggaagcaac                                                   20


<210>  31037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31037
cagagcccug cgauggcuuc                                                   20


<210>  31038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31038
cucccagugg ccggcaagcc                                                   20


<210>  31039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31039
uucucuccca guggccggca                                                   20


<210>  31040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31040
uccucccugu ccauucauuc                                                   20


<210>  31041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31041
ggugagagua aaggugacgc                                                   20


<210>  31042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31042
cacaccugcu cugccaucac                                                   20


<210>  31043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31043
ggauggaucc ugaaggcagg                                                   20


<210>  31044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31044
ggauccaucc ugaaucugac                                                   20


<210>  31045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31045
ccaccaccug ccuucaggau                                                   20


<210>  31046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31046
ggcugacucc aagaugggcu                                                   20


<210>  31047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31047
cuccagccca ucuuggaguc                                                   20


<210>  31048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31048
uccagugacc ggagaggagg                                                   20


<210>  31049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31049
cagcccugcu cacgucuccc                                                   20


<210>  31050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31050
uuuucucaga uggucagccc                                                   20


<210>  31051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31051
cagaugguca gccccuagug                                                   20


<210>  31052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31052
ucacaccugc cucccaccuu                                                   20


<210>  31053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31053
agccuccccu uuccucacac                                                   20


<210>  31054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31054
aagccuucaa gccuccccuu                                                   20


<210>  31055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31055
ucaacagcau caagagccca                                                   20


<210>  31056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31056
gguccgcaug ggcucuugau                                                   20


<210>  31057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31057
gccacaccug gacggugcag                                                   20


<210>  31058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31058
ucguccacug gagccagcgu                                                   20


<210>  31059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31059
cuguguccau uuccucgucc                                                   20


<210>  31060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31060
acaggauggg caaagcaugg                                                   20


<210>  31061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31061
aacucuggcc uggaggugua                                                   20


<210>  31062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31062
ucucugagcg ucccucucau                                                   20


<210>  31063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31063
uccuccaucc ccccagugac                                                   20


<210>  31064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31064
ccagugacuu cauccuccau                                                   20


<210>  31065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31065
cuucuccagu gacuucaucc                                                   20


<210>  31066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31066
uagcagcugu gccuggguaa                                                   20


<210>  31067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31067
gauguccuuu ucauguguuu                                                   20


<210>  31068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31068
uguguuucca uauaugaagc                                                   20


<210>  31069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31069
auauaugaag ccaugggugc                                                   20


<210>  31070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31070
uauauggaaa cacaugaaaa                                                   20


<210>  31071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31071
cccggcuacc ucacucugcu                                                   20


<210>  31072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31072
ucccacagga cacugacagg                                                   20


<210>  31073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31073
ugcagcccug ucaguguccu                                                   20


<210>  31074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31074
gguacauauu uauacauucu                                                   20


<210>  31075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31075
guuuguuuua ggccuaacau                                                   20


<210>  31076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31076
cugcagucau uucuguuugu                                                   20


<210>  31077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31077
gcuuuuucac ugcagucauu                                                   20


<210>  31078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31078
ccaucuuggc caggcugguc                                                   20


<210>  31079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31079
gaguaccugg gauuacaggc                                                   20


<210>  31080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31080
uuuuugagac ggagucaugc                                                   20


<210>  31081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31081
uuuuucuuuu uugagacgga                                                   20


<210>  31082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31082
uuucuuuuuu cuuuuuugag                                                   20


<210>  31083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31083
gcuuuuucuu uucuuuuuuc                                                   20


<210>  31084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31084
gcuaggcucg gggaggggaa                                                   20


<210>  31085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31085
ccuccccgag ccuagcagaa                                                   20


<210>  31086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31086
uccccucccc gagccuagca                                                   20


<210>  31087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31087
auccacuuac gacacccauu                                                   20


<210>  31088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31088
agaugaaauc cgugguguug                                                   20


<210>  31089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31089
ucuugaaagc cccugagccu                                                   20


<210>  31090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31090
cagcaccucc aacaccacgg                                                   20


<210>  31091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31091
cacacagagc ccucacucag                                                   20


<210>  31092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31092
aagcuagagc uucucacaca                                                   20


<210>  31093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31093
cauuuaugaa auguagauga                                                   20


<210>  31094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31094
uaaaugagaa acugagcugg                                                   20


<210>  31095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31095
uuuuauccuc ccaacaaucc                                                   20


<210>  31096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31096
ccucuuagua auuauggagg                                                   20


<210>  31097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31097
uucuuaaaga auggguucua                                                   20


<210>  31098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31098
uaaagaaugg guucuauggg                                                   20


<210>  31099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31099
uuaagaacga acuguuucuc                                                   20


<210>  31100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31100
auggguuaac gacgucacac                                                   20


<210>  31101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31101
gucauagcag cccaaaggga                                                   20


<210>  31102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31102
gcuguugaua aauuacucag                                                   20


<210>  31103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31103
cagucaggag gcuggaaguc                                                   20


<210>  31104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31104
agccuccuga cugagaaaau                                                   20


<210>  31105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31105
aagauggagc cuuggcugga                                                   20


<210>  31106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31106
uuuaaaauau agacggcauc                                                   20


<210>  31107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31107
uucuuuuaaa auauagacgg                                                   20


<210>  31108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31108
uucuuucuuu uaaaauauag                                                   20


<210>  31109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31109
uucuuucuuu cuuuuaaaau                                                   20


<210>  31110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31110
uuucuuucuu ucuuucuuuu                                                   20


<210>  31111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31111
uuucuuuucu uucuuucuuu                                                   20


<210>  31112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31112
uucuuuucuu uucuuucuuu                                                   20


<210>  31113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31113
cacugcaccc ucacagggca                                                   20


<210>  31114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31114
aauggcagga aucccauuca                                                   20


<210>  31115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31115
ugccauuaga aaaggggccc                                                   20


<210>  31116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31116
cgagggcaga gccuucauga                                                   20


<210>  31117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31117
ugaccucauc accuccagaa                                                   20


<210>  31118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31118
ggaggugaug aggucaugaa                                                   20


<210>  31119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31119
gcuuacagau uuguggggga                                                   20


<210>  31120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31120
gagcauccug gcccucgaug                                                   20


<210>  31121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31121
gcaucucagg gacuccacag                                                   20


<210>  31122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31122
gaucuguuuu auuaauuuau                                                   20


<210>  31123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31123
uugagacgga gucucaagaa                                                   20


<210>  31124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31124
ugagacuccg ucucaaagaa                                                   20


<210>  31125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31125
agggauucuc cugccucagg                                                   20


<210>  31126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31126
ccugccucag gcuccugagu                                                   20


<210>  31127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31127
ccauguuggc caggaugguc                                                   20


<210>  31128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31128
cauccguuuu aaauuaacaa                                                   20


<210>  31129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31129
uugcaugcuu uguuaauuua                                                   20


<210>  31130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31130
ggaagcuuug agucuagcag                                                   20


<210>  31131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31131
ugaagcuaag gcugugugac                                                   20


<210>  31132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31132
cagcaagaaa uacuugucau                                                   20


<210>  31133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31133
ugcugagaau gagucauuug                                                   20


<210>  31134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31134
ggcccccaua ccugcacuag                                                   20


<210>  31135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31135
gguuuuagcu uucuggcccc                                                   20


<210>  31136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31136
ucagguuuua gcuuucuggc                                                   20


<210>  31137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31137
gcuugcugac uccugcuaaa                                                   20


<210>  31138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31138
aucucccacc gcucucagcu                                                   20


<210>  31139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31139
ggucugcgcu ucuaucuccc                                                   20


<210>  31140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31140
ggucuuuggg acuuugaguu                                                   20


<210>  31141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31141
guaaggccag augguaaaca                                                   20


<210>  31142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31142
acucugccgc uauaguggaa                                                   20


<210>  31143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31143
acuauagcgg cagaguugaa                                                   20


<210>  31144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31144
aaaaccaggc agcuggugcc                                                   20


<210>  31145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31145
caagcccagg ucuaggucac                                                   20


<210>  31146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31146
gggguccagg ucuuucaugu                                                   20


<210>  31147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31147
uguguugcuu uugagcacag                                                   20


<210>  31148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31148
gauugaugag aauugcggag                                                   20


<210>  31149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31149
caucaaucag aaaaagcagg                                                   20


<210>  31150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31150
uccgcaauuc ucaucaauca                                                   20


<210>  31151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31151
ucacauacau auuuaccauc                                                   20


<210>  31152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31152
aaagagaucc uuucugguaa                                                   20


<210>  31153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31153
gguaauuuua agaauauacu                                                   20


<210>  31154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31154
uaaaauuacc agaaaggauc                                                   20


<210>  31155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31155
aguauauucu uaaaauuacc                                                   20


<210>  31156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31156
uaauauuuug guauucuagu                                                   20


<210>  31157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31157
caaaauaucu ucuuaauauu                                                   20


<210>  31158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31158
gaaauugaca acaguuucug                                                   20


<210>  31159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31159
gaaauaccac uaaggaccuc                                                   20


<210>  31160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31160
guuuccucuu uaaaaauccc                                                   20


<210>  31161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31161
ucuuuaaaaa uccccacauu                                                   20


<210>  31162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31162
uuaaguuaaa aaaauuaauc                                                   20


<210>  31163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31163
ccuuugagcu aucaauaaau                                                   20


<210>  31164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31164
ccccccuccu uugugaagug                                                   20


<210>  31165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31165
caaaggaggg gggcgaaggu                                                   20


<210>  31166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31166
ugaggucugc uugaugcuug                                                   20


<210>  31167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31167
aagcaucaag cagaccucag                                                   20


<210>  31168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31168
ccguggucuc caucuccuga                                                   20


<210>  31169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31169
ccugccucag ccucccgagu                                                   20


<210>  31170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31170
cgccauucuc cugccucagc                                                   20


<210>  31171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31171
gucacccagg cuggagugca                                                   20


<210>  31172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31172
uuuuuugaga uggagucucg                                                   20


<210>  31173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31173
uuuuuuuucu uuuuuugaga                                                   20


<210>  31174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31174
uuuuuaucca gaggcucaag                                                   20


<210>  31175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31175
gccucuugca guuacucacc                                                   20


<210>  31176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31176
uggugaguaa cugcaagagg                                                   20


<210>  31177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31177
ccccagccgc ucccucgccc                                                   20


<210>  31178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31178
aggacaucaa cuucaggagg                                                   20


<210>  31179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31179
ggaggcugga ggcaaacaug                                                   20


<210>  31180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31180
guccugaugu aagugcauug                                                   20


<210>  31181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31181
uagggcccug cucguccugg                                                   20


<210>  31182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31182
cuuucuuuuu ucaaaaauag                                                   20


<210>  31183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31183
uuuuucaaaa auagagaugg                                                   20


<210>  31184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31184
aaaauagaga uggggggucu                                                   20


<210>  31185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31185
guaucuguug uaauaaaaaa                                                   20


<210>  31186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31186
ucuucccucc cccgucaccc                                                   20


<210>  31187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31187
ucccuccccc gucaccccag                                                   20


<210>  31188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31188
cucccccguc accccagugu                                                   20


<210>  31189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31189
cuucuuuucu agagacgggg                                                   20


<210>  31190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31190
uuucuagaga cgggggucuc                                                   20


<210>  31191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31191
agagacgggg gucucccuau                                                   20


<210>  31192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31192
aaaguagccu gggcaacaua                                                   20


<210>  31193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31193
gggaggucaa ggcaggagga                                                   20


<210>  31194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31194
ggucucaggg cuggcuuucu                                                   20


<210>  31195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31195
cucucauucu uguguuuccc                                                   20


<210>  31196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31196
uguguuuccc acagccguga                                                   20


<210>  31197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31197
cacagccgug aggcccugcu                                                   20


<210>  31198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31198
uuugucugga acgcgugucc                                                   20


<210>  31199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31199
agacaaagga agcagggccu                                                   20


<210>  31200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31200
caugaggucc ugggacugug                                                   20


<210>  31201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31201
ggguccucag uacggggcca                                                   20


<210>  31202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31202
ucuggacugu ccccgagggg                                                   20


<210>  31203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31203
gccuccccac cuugagggua                                                   20


<210>  31204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31204
uacccucaag guggggaggc                                                   20


<210>  31205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31205
cucauucaua cccucaaggu                                                   20


<210>  31206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31206
gcaaagcagu ggcuccaaag                                                   20


<210>  31207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31207
cccaggacuu gugcacuaca                                                   20


<210>  31208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31208
caggacugcg ggugccuccg                                                   20


<210>  31209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31209
gugcuuuuug uuccuuugcc                                                   20


<210>  31210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31210
uuugcccuga aagugcaagg                                                   20


<210>  31211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31211
gggcaaagga acaaaaagca                                                   20


<210>  31212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31212
uugcacuuuc agggcaaagg                                                   20


<210>  31213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31213
ugucccagag gagggaccug                                                   20


<210>  31214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31214
gggagcugag cggagggaug                                                   20


<210>  31215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31215
cauccuccug cagguccacu                                                   20


<210>  31216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31216
ucagguuuuc uccgggugcu                                                   20


<210>  31217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31217
ccgggugcuu ugccaggagu                                                   20


<210>  31218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31218
uggugcacuc cuggcaaagc                                                   20


<210>  31219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31219
cgccccugcc uccaauucuu                                                   20


<210>  31220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31220
cacuucuccg guucugugcu                                                   20


<210>  31221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31221
ccgguucugu gcugcaucuu                                                   20


<210>  31222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31222
gugcugcauc uuccaauacg                                                   20


<210>  31223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31223
aauacgugca guccacccug                                                   20


<210>  31224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31224
guagugcaaa auggauugca                                                   20


<210>  31225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31225
ccuuuccgua gugcaaaaug                                                   20


<210>  31226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31226
cacacacaca cacacacaca                                                   20


<210>  31227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31227
ccagcuuuua gugucaccaa                                                   20


<210>  31228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31228
gaggacacau ucugugauuu                                                   20


<210>  31229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31229
gugauuuaga aaaugccuca                                                   20


<210>  31230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31230
aaaucacaga auguguccuc                                                   20


<210>  31231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31231
uuugccaggc cccucucacu                                                   20


<210>  31232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31232
uucuugggaa cugagggagc                                                   20


<210>  31233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31233
ugggaacuga gggagcugag                                                   20


<210>  31234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31234
caagaaugaa acgcccagca                                                   20


<210>  31235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31235
cagcucccuc aguucccaag                                                   20


<210>  31236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31236
ugcuacacag ccucaugccg                                                   20


<210>  31237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31237
cgguggugaa agggaucuac                                                   20


<210>  31238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31238
ccaccgagaa cugcucgaua                                                   20


<210>  31239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31239
ucugcggugu ccagguagau                                                   20


<210>  31240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31240
augcucgguu ugcuaccggg                                                   20


<210>  31241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31241
gccaggggau ggagacacac                                                   20


<210>  31242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31242
agcacagccg cuuuacguua                                                   20


<210>  31243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31243
aacagugacc cagggaaaag                                                   20


<210>  31244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31244
cugggucacu guuggaacua                                                   20


<210>  31245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31245
agaccagccu ggccaacaua                                                   20


<210>  31246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31246
cuauguuggc caggcugguc                                                   20


<210>  31247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31247
ccugccucag caucccuacu                                                   20


<210>  31248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31248
agcgauucuc cugccucagc                                                   20


<210>  31249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31249
gccucccagg uucaagcgau                                                   20


<210>  31250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31250
gucgcccaag guggaguaca                                                   20


<210>  31251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31251
ucucacccaa aaaaaaaaaa                                                   20


<210>  31252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31252
ggacagcugc ugauaugguc                                                   20


<210>  31253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31253
ugucauuggg accagggaca                                                   20


<210>  31254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31254
caugguaguu cccugcuuug                                                   20


<210>  31255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31255
cugcuuuggg aguacacuca                                                   20


<210>  31256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31256
aagaagaggu caggaagcag                                                   20


<210>  31257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31257
uggaauaagu aauguggucu                                                   20


<210>  31258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31258
ugaccucuuc uuggaauaag                                                   20


<210>  31259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31259
cugcuuccug accucuucuu                                                   20


<210>  31260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31260
uccuucccug cuuccugacc                                                   20


<210>  31261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31261
ggguuccucc uucccugcuu                                                   20


<210>  31262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31262
cugcggcuuc ucuguccugu                                                   20


<210>  31263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31263
cuguccuguu auucugugca                                                   20


<210>  31264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31264
gugcaugcag augaucgaau                                                   20


<210>  31265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31265
aucaucugca ugcacagaau                                                   20


<210>  31266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31266
aagacaucaa caaaagugaa                                                   20


<210>  31267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31267
cuuuuguuga ugucuuugaa                                                   20


<210>  31268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31268
ucacuuucac uuuuguugau                                                   20


<210>  31269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31269
ugucuagauc uaauggcaaa                                                   20


<210>  31270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31270
agaccaaaca gaggcuucuu                                                   20


<210>  31271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31271
ucuauagacu cuucagaaga                                                   20


<210>  31272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31272
auagacucuu cagaagaggg                                                   20


<210>  31273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31273
gaagaggggu aaaaagacuu                                                   20


<210>  31274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31274
gaagagucua uagaagaagc                                                   20


<210>  31275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31275
cauacacaca cauauauuag                                                   20


<210>  31276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31276
ccuuggcagu caguauguuu                                                   20


<210>  31277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31277
guuugcgaug gcuccuacag                                                   20


<210>  31278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31278
ggcuggccuc caccuagcac                                                   20


<210>  31279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31279
cauuguucug gcuggccucc                                                   20


<210>  31280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31280
ucccagcaac aaaccucacu                                                   20


<210>  31281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31281
gauccaaaac aggacuaccu                                                   20


<210>  31282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31282
agcauuuaca aacagguucc                                                   20


<210>  31283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31283
cgugucgcug acaaaauagu                                                   20


<210>  31284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31284
gagcccagug uaaacuauuu                                                   20


<210>  31285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31285
acaggaugcc gauuucugag                                                   20


<210>  31286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31286
ucagauggca cucacagugc                                                   20


<210>  31287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31287
cccgcugcac ggggaaagug                                                   20


<210>  31288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31288
ccgugcagcg ggcgaaggag                                                   20


<210>  31289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31289
uuuuugaaaa gggaauccug                                                   20


<210>  31290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31290
aaaaggaauc cacuuucccc                                                   20


<210>  31291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31291
cuuuucaaaa aggaauccac                                                   20


<210>  31292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31292
acuaaaaaua caaaacuuag                                                   20


<210>  31293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31293
ccugccucag ccucccaagu                                                   20


<210>  31294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31294
cgcgauucuc cugccucagc                                                   20


<210>  31295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31295
uuuugagaug gagucuugcg                                                   20


<210>  31296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31296
uucuuuuuga gauggagucu                                                   20


<210>  31297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31297
uucuuucuuu uugagaugga                                                   20


<210>  31298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31298
auuuuucuuu cuuucuuuuu                                                   20


<210>  31299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31299
aaaggauucc auuuuucuuu                                                   20


<210>  31300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31300
guaauagcau uaaauguaga                                                   20


<210>  31301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31301
augcaaagug ucucuccuug                                                   20


<210>  31302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31302
ugggccaucc uacuuugcac                                                   20


<210>  31303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31303
caggggguug auucagagcu                                                   20


<210>  31304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31304
gagcuuggcc acuaacauuc                                                   20


<210>  31305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31305
aauccaucuu ucuuucagua                                                   20


<210>  31306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31306
uucaguauga aaaauaggcu                                                   20


<210>  31307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31307
guaugaaaaa uaggcuaggc                                                   20


<210>  31308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31308
uacugaaaga aagauggauu                                                   20


<210>  31309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31309
agaccagcuu agccaacaug                                                   20


<210>  31310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31310
ccauguuggc uaagcugguc                                                   20


<210>  31311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31311
ccugccucag acucccaggu                                                   20


<210>  31312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31312
agcgauucuc cugccucaga                                                   20


<210>  31313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31313
cucuugucac ccaggcugga                                                   20


<210>  31314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31314
uuuuuuuuuu uuuuuuuuua                                                   20


<210>  31315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31315
caccuaaagc uuauuuuuuu                                                   20


<210>  31316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31316
cauggcuguc uuuccucuga                                                   20


<210>  31317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31317
ucugagaacu aaggguuagg                                                   20


<210>  31318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31318
cagaggaaag acagccaugg                                                   20


<210>  31319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31319
caccuaaccc uuaguucuca                                                   20


<210>  31320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31320
augcagggcu ggcuacacac                                                   20


<210>  31321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31321
aucuccaagu guggacacug                                                   20


<210>  31322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31322
cacguuuugg ggaaaaccug                                                   20


<210>  31323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31323
ccaaaacgug ggaaccuggg                                                   20


<210>  31324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31324
cucaacggca gguuuucccc                                                   20


<210>  31325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31325
cucugugcaa ucagauucuc                                                   20


<210>  31326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31326
ccccacacug cuucuuaggc                                                   20


<210>  31327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31327
uaggcagcca gagacccugu                                                   20


<210>  31328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31328
ugccucagcc augguacaug                                                   20


<210>  31329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31329
gcauguacca uggcugaggc                                                   20


<210>  31330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31330
uauguaugug agcuaagcau                                                   20


<210>  31331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31331
ugauguggua gaugcuuagc                                                   20


<210>  31332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31332
ccuuauuuac uucaugaugu                                                   20


<210>  31333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31333
gguuuuugcc ugccuuaaaa                                                   20


<210>  31334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31334
agagcaaccu ggccaacaug                                                   20


<210>  31335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31335
ccauguuggc cagguugcuc                                                   20


<210>  31336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31336
ucagccuccu gaguagcuag                                                   20


<210>  31337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31337
ccuuccucag ccuccugagu                                                   20


<210>  31338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31338
agcaauucuc cuuccucagc                                                   20


<210>  31339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31339
agguucaagc aauucuccuu                                                   20


<210>  31340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31340
uuaagugcag acaaccauuu                                                   20


<210>  31341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31341
cuuuccuuaa gugcagacaa                                                   20


<210>  31342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31342
caucagccgu gugccugagg                                                   20


<210>  31343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31343
cacuggggac cauggucagg                                                   20


<210>  31344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31344
uucucacugg ggaccauggu                                                   20


<210>  31345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31345
acuuccuucu cacuggggac                                                   20


<210>  31346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31346
uggcgccagg gucugcucug                                                   20


<210>  31347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31347
aggugggacg agacgcuaac                                                   20


<210>  31348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31348
gcacuaauac cugaguuguc                                                   20


<210>  31349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31349
cuaaagcugg auugaagaaa                                                   20


<210>  31350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31350
auccagcuuu agugaaaaga                                                   20


<210>  31351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31351
ucaauccagc uuuagugaaa                                                   20


<210>  31352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31352
gugcuggggu gcccaggugu                                                   20


<210>  31353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31353
cugcacccag ggagaggcca                                                   20


<210>  31354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31354
caagcccccg cuggccucuc                                                   20


<210>  31355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31355
uggaccacca caucucuggc                                                   20


<210>  31356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31356
ccagggcccg ggugucagac                                                   20


<210>  31357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31357
ugcaucuccc gauggcuguc                                                   20


<210>  31358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31358
uucgguuugu guguuugugg                                                   20


<210>  31359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31359
guuugugugu uuguggccag                                                   20


<210>  31360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31360
uuuucucuga gcauaucuau                                                   20


<210>  31361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31361
cugagcauau cuaucugccc                                                   20


<210>  31362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31362
agggcagaua gauaugcuca                                                   20


<210>  31363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31363
cguggagguu aagggcgcug                                                   20


<210>  31364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31364
gcgcccuuaa ccuccacggg                                                   20


<210>  31365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31365
gcuggggugc ucacccgcgg                                                   20


<210>  31366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31366
ccaagcgcac aaagccacgu                                                   20


<210>  31367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31367
gcuacgcccu ggcguggggu                                                   20


<210>  31368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31368
gugccggucc acacccuucc                                                   20


<210>  31369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31369
ugcccuggca cacgcacggg                                                   20


<210>  31370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31370
cagggggcga cguuggagcu                                                   20


<210>  31371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31371
cuccccgccc agcuccaacg                                                   20


<210>  31372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31372
aggccgccag cgagggcccu                                                   20


<210>  31373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31373
cuaaggaucu gggcgcagcu                                                   20


<210>  31374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31374
gcaccuucuc uaaggaucug                                                   20


<210>  31375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31375
ugaacugugc uucgcaggau                                                   20


<210>  31376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31376
ggaaaaaggc ccaaguuccg                                                   20


<210>  31377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31377
caggaugggc cggcccggcg                                                   20


<210>  31378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31378
gcagggcagg gcagcacuug                                                   20


<210>  31379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31379
gggaggagcu gacggggaca                                                   20


<210>  31380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31380
ccuccgcccc auccauucuc                                                   20


<210>  31381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31381
ccacugcugu cagggcugcc                                                   20


<210>  31382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31382
cacgcagcag gcagcacaga                                                   20


<210>  31383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31383
aagucaccga ggccugugcc                                                   20


<210>  31384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31384
ucucccgcgc gcagcugucc                                                   20


<210>  31385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31385
caagagcagc aggagcgacc                                                   20


<210>  31386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31386
aggcggacgu uucccuugca                                                   20


<210>  31387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31387
cuugcaucgg ggugugggga                                                   20


<210>  31388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31388
ccacaccccg augcaaggga                                                   20


<210>  31389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31389
gcaggugccc accgccggcu                                                   20


<210>  31390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31390
ucccaggacg ggccccagug                                                   20


<210>  31391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31391
uuguacgagg ggaaggggaa                                                   20


<210>  31392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31392
ccucguacaa agaaggcucc                                                   20


<210>  31393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31393
ccuuccccuc guacaaagaa                                                   20


<210>  31394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31394
uugggggaau ggaaauagcu                                                   20


<210>  31395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31395
cccaaagaau aaagacccca                                                   20


<210>  31396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31396
auucccccaa agaauaaaga                                                   20


<210>  31397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31397
ucugauugag gcaaaacuca                                                   20


<210>  31398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31398
gauugaggca aaacucauua                                                   20


<210>  31399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31399
aaaaagccuu acucuuuaau                                                   20


<210>  31400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31400
gcagcugagg acagugaggc                                                   20


<210>  31401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31401
uucugcagcu gaggacagug                                                   20


<210>  31402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31402
gagucuguaa aucauguagc                                                   20


<210>  31403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31403
acacugugcu acaugauuua                                                   20


<210>  31404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31404
guaacuaugc caauaaucgu                                                   20


<210>  31405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31405
cacgauuauu ggcauaguua                                                   20


<210>  31406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31406
gcaaugagca gguauuauuu                                                   20


<210>  31407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31407
uguauuuucu gcaaugagca                                                   20


<210>  31408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31408
ugcauguuuu ccuguauuuu                                                   20


<210>  31409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31409
uuccugcaug uuuuccugua                                                   20


<210>  31410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31410
acccccaccc ccauuuccac                                                   20


<210>  31411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31411
acucugacuc uuuccaggag                                                   20


<210>  31412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31412
aggaguucuu ccaucagugu                                                   20


<210>  31413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31413
uccaucagug uagacaaagu                                                   20


<210>  31414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31414
aucaguguag acaaagucca                                                   20


<210>  31415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31415
gcuguggacu uugucuacac                                                   20


<210>  31416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31416
uugccagcca cagggccucu                                                   20


<210>  31417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31417
acaccugcgc gaggcaggcc                                                   20


<210>  31418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31418
aaugccucug acaggcaggu                                                   20


<210>  31419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31419
agauggaguu gcucuuguuc                                                   20


<210>  31420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31420
caggagguua ggcauucuua                                                   20


<210>  31421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31421
uaguuacagg augagauagg                                                   20


<210>  31422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31422
uuaaaacagu cuguuuuauc                                                   20


<210>  31423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31423
cuauuuuggc cagggugguc                                                   20


<210>  31424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31424
ccugccucag ccucccgagu                                                   20


<210>  31425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31425
agagauucuc cugccucagc                                                   20


<210>  31426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31426
uuauuuuauu auuuuuuuug                                                   20


<210>  31427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31427
uuauuuacuu cuuuauuuua                                                   20


<210>  31428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31428
cagcuucuuu auuuacuucu                                                   20


<210>  31429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31429
gaugccaugg caacgucuga                                                   20


<210>  31430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31430
gacguugcca uggcaucuga                                                   20


<210>  31431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31431
aaaaagagga ggaacucuca                                                   20


<210>  31432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31432
uccucuuuuu agaacauaca                                                   20


<210>  31433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31433
gggaaucgcc caccccuuuc                                                   20


<210>  31434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31434
cagaacugag aguuccuccu                                                   20


<210>  31435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31435
cagaaaucuc augaauaauc                                                   20


<210>  31436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31436
gggaaagggg ugggcgauuc                                                   20


<210>  31437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31437
ugagauuucu gggaaagggg                                                   20


<210>  31438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31438
ugauuauaug cuaaacaagg                                                   20


<210>  31439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31439
uuauuccuuu acuuuccuaa                                                   20


<210>  31440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31440
uuuacuuucc uaagaaacuu                                                   20


<210>  31441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31441
uaagaaacuu gcuuucccuu                                                   20


<210>  31442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31442
uaggaaagua aaggaauaaa                                                   20


<210>  31443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31443
cuuuauggau uagccucgaa                                                   20


<210>  31444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31444
aggcuaaucc auaaagggaa                                                   20


<210>  31445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31445
ugagcgagau ccaaguaccc                                                   20


<210>  31446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31446
uccucagcag gcaagaugga                                                   20


<210>  31447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31447
caggucuagu uuccuccuca                                                   20


<210>  31448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31448
uacccugggc ugguggcuau                                                   20


<210>  31449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31449
auagccacca gcccagggua                                                   20


<210>  31450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31450
uuguuucuuu uuuugcuuaa                                                   20


<210>  31451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31451
uuuuuugcuu aagcuagucu                                                   20


<210>  31452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31452
ccaugcccaa gugaaagcuu                                                   20


<210>  31453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31453
cuugggcaug gggaaauuua                                                   20


<210>  31454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31454
cucagucaaa gcuuucacuu                                                   20


<210>  31455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31455
auuaacaugu ugaacaucuc                                                   20


<210>  31456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31456
acauguuaau ugaacaaguu                                                   20


<210>  31457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31457
cuuucuguuu auaagcaagc                                                   20


<210>  31458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31458
guuuauaagc aagcauguau                                                   20


<210>  31459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31459
auacauacau gcuugcuuau                                                   20


<210>  31460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31460
cuucaauaca uacaugcuug                                                   20


<210>  31461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31461
aaguucucuu caauacauac                                                   20


<210>  31462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31462
uaauuucaaa guucucuuca                                                   20


<210>  31463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31463
ucuuaauuuc aaaguucucu                                                   20


<210>  31464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31464
aguuuuagug uauaugcugc                                                   20


<210>  31465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31465
cuguaucauu ccaguuuuag                                                   20


<210>  31466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31466
caaauuugug ugucguccuu                                                   20


<210>  31467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31467
auacaaaaau auauuuaaaa                                                   20


<210>  31468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31468
uuuuuuaaau auauuuuugu                                                   20


<210>  31469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31469
uuccauguca uuuggcugcu                                                   20


<210>  31470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31470
augucauuug gcugcuuaaa                                                   20


<210>  31471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31471
agugauucuc augccucagc                                                   20


<210>  31472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31472
caugccucag cuucccggau                                                   20


<210>  31473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31473
cggauagcug ggauuacagg                                                   20


<210>  31474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31474
ccauguugac caggcugguc                                                   20


<210>  31475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31475
agaccagccu ggucaacaug                                                   20


<210>  31476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31476
gucauccaug auauugugaa                                                   20


<210>  31477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31477
caauaucaug gaugacugaa                                                   20


<210>  31478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31478
uucagucucc uggcauauau                                                   20


<210>  31479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31479
gucuccuggc auauauuucc                                                   20


<210>  31480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31480
ccaaauccuu ggaaucuuca                                                   20


<210>  31481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31481
aaggauuugg ggaaauauau                                                   20


<210>  31482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31482
aagugaugaa ugucuuuuuu                                                   20


<210>  31483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31483
ucacuuugaa gauuccaagg                                                   20


<210>  31484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31484
agauaggagg uggggcuggu                                                   20


<210>  31485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31485
ggugaccagc cccaccuccu                                                   20


<210>  31486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31486
uucuggugac cagccccacc                                                   20


<210>  31487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31487
ucuuucuggu gaccagcccc                                                   20


<210>  31488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31488
aacccuaccu ucuucuuucu                                                   20


<210>  31489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31489
cagagggcaa gaguagggcu                                                   20


<210>  31490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31490
ucacauaggc augauuuaau                                                   20


<210>  31491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31491
gagagcuucc ggguaacgug                                                   20


<210>  31492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31492
ggguaacgug gagguuucua                                                   20


<210>  31493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31493
agagggcagc gcaccucccu                                                   20


<210>  31494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31494
acggggacag aagcuccugu                                                   20


<210>  31495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31495
guccccguag aagggaggug                                                   20


<210>  31496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31496
agaacgcucc cuaugcaucu                                                   20


<210>  31497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31497
ggaagggucc caagcacagg                                                   20


<210>  31498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31498
caucuggcug uucaucugua                                                   20


<210>  31499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31499
ucuguauccu guaaaauaug                                                   20


<210>  31500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31500
ugguuuauua caaggcauau                                                   20


<210>  31501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31501
cugaguucug uaugcugauc                                                   20


<210>  31502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31502
guaugcugau cuagcaaauu                                                   20


<210>  31503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31503
auuaauuugc uagaucagca                                                   20


<210>  31504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31504
cacagccccc uccuuggguu                                                   20


<210>  31505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31505
gacugaccug cuaaacauug                                                   20


<210>  31506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31506
aaugccaacu gcaagccccu                                                   20


<210>  31507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31507
gucuuguggg aacugagucc                                                   20


<210>  31508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31508
cacaagacug aaccccguuu                                                   20


<210>  31509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31509
agucugacgg caucuaccug                                                   20


<210>  31510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31510
gcagcggaca ccagcugggu                                                   20


<210>  31511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31511
ccccacccac aagcaagcaa                                                   20


<210>  31512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31512
guguugauuc uugagugaga                                                   20


<210>  31513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31513
ugagugagag aacaggaaaa                                                   20


<210>  31514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31514
cucacucaag aaucaacaca                                                   20


<210>  31515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31515
uguucucuca cucaagaauc                                                   20


<210>  31516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31516
ccuagauccu caggguggcu                                                   20


<210>  31517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31517
gccacccuga ggaucuaggg                                                   20


<210>  31518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31518
auauguauau ucagccaccc                                                   20


<210>  31519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31519
uaacuccucc uacagcguau                                                   20


<210>  31520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31520
ugccucuuca ugggucacgu                                                   20


<210>  31521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31521
ugggucacgu guucaaaaaa                                                   20


<210>  31522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31522
aaaaauguug ggguuagcgu                                                   20


<210>  31523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31523
ucccucugac gucaaaaggu                                                   20


<210>  31524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31524
ccuuuugacg ucagagggag                                                   20


<210>  31525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31525
cguguccucu gcuucaccuu                                                   20


<210>  31526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31526
ugguaagaga ccacagagcc                                                   20


<210>  31527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31527
cuuccuggua agagaccaca                                                   20


<210>  31528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31528
auugccuuua gccaaucauc                                                   20


<210>  31529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31529
uuuuuucuag agcugguuuc                                                   20


<210>  31530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31530
agagcugguu ucuguuuauu                                                   20


<210>  31531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31531
guuuauucuu uaggaaggca                                                   20


<210>  31532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31532
uuaggaaggc auuccaguga                                                   20


<210>  31533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31533
uaaagaauaa acagaaacca                                                   20


<210>  31534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31534
agugaaaggg uauuaaggaa                                                   20


<210>  31535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31535
cuggaaugcc uuccuaaaga                                                   20


<210>  31536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31536
uuaauacccu uucacuggaa                                                   20


<210>  31537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31537
uggccgugac aggacagguc                                                   20


<210>  31538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31538
cugaggucuc cucgaccaag                                                   20


<210>  31539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31539
uggucgagga gaccucagag                                                   20


<210>  31540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31540
uauguaccuc aagggagcag                                                   20


<210>  31541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31541
aacacuguuu ugagugcaua                                                   20


<210>  31542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31542
uuaaaauguu caaacacugu                                                   20


<210>  31543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31543
uuuaacagag guauauaaua                                                   20


<210>  31544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31544
gccaaauuaa auuuaaauga                                                   20


<210>  31545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31545
uugcucaauu aaacucauuu                                                   20


<210>  31546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31546
cgaauugggc agcccccaga                                                   20


<210>  31547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31547
ugaaucguuc auugcucaau                                                   20


<210>  31548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31548
gggggcugcc caauucguga                                                   20


<210>  31549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31549
gagggacucc agggauaccu                                                   20


<210>  31550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31550
gaccacgagg uaucccugga                                                   20


<210>  31551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31551
cuuuuuuguc uauagauuug                                                   20


<210>  31552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31552
auaugucacu ucccuuuuuu                                                   20


<210>  31553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31553
guacucaccu ccaauuucua                                                   20


<210>  31554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31554
aacugugucc aaauaaggca                                                   20


<210>  31555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31555
cucguacacu gcugagaguu                                                   20


<210>  31556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31556
gucuugucua ccaauuaagu                                                   20


<210>  31557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31557
uccacaagga cucaaauaga                                                   20


<210>  31558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31558
cuauuugagu ccuuguggac                                                   20


<210>  31559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31559
caggccauau uuaguuugcu                                                   20


<210>  31560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31560
acccuuuugg ucauuuucuc                                                   20


<210>  31561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31561
caauuuugag agauugacca                                                   20


<210>  31562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31562
ggaccaaaua aguacauuua                                                   20


<210>  31563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31563
cagaggguuu caggaccaaa                                                   20


<210>  31564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31564
acuguuucuc agaggguuuc                                                   20


<210>  31565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31565
uaccuuugca aaacucacug                                                   20


<210>  31566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31566
agcauaagga gguacccuca                                                   20


<210>  31567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31567
ccuauaaaca ggacguucca                                                   20


<210>  31568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31568
uuaaagucuu aguuugauua                                                   20


<210>  31569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31569
ccuuucuguc cagguucuca                                                   20


<210>  31570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31570
guccagguuc ucacuuaggu                                                   20


<210>  31571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31571
cacuuaggug agugugggcg                                                   20


<210>  31572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31572
aguauaauaa aaaauauaua                                                   20


<210>  31573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31573
auauauauau uuuuuauuau                                                   20


<210>  31574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31574
uauucuauau auauauuuuu                                                   20


<210>  31575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31575
ccguguuagc caggaugguc                                                   20


<210>  31576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31576
ccugccucag ccucccgagu                                                   20


<210>  31577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31577
ugccauucuc cugccucagc                                                   20


<210>  31578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31578
uuuuguuuug uuuuguuuug                                                   20


<210>  31579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31579
aguauaacua uucuuuuugu                                                   20


<210>  31580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31580
aauauuauaa uaaucuuugu                                                   20


<210>  31581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31581
acaauuauaa ccuaggaaaa                                                   20


<210>  31582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31582
uagguuauaa uuguagaaca                                                   20


<210>  31583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31583
gcuccuaucu cuguauggcc                                                   20


<210>  31584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31584
cacccugucc cuucagcucc                                                   20


<210>  31585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31585
ggucacuucu cacccugucc                                                   20


<210>  31586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31586
caggcacugu cauuaccacu                                                   20


<210>  31587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31587
cuggucggcu aaguaacagg                                                   20


<210>  31588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31588
cuaaccccuc cgccccucuc                                                   20


<210>  31589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31589
acaagagaug guggagcaga                                                   20


<210>  31590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31590
gcggucacgc uccuguuuca                                                   20


<210>  31591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31591
cuuucauguu ccgcucugua                                                   20


<210>  31592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31592
uguuccgcuc uguacaccug                                                   20


<210>  31593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31593
gcucuguaca ccuggcucca                                                   20


<210>  31594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31594
agauagcagu agcagaauua                                                   20


<210>  31595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31595
gcuacugcua ucuagaagau                                                   20


<210>  31596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31596
cuaauucugc uacugcuauc                                                   20


<210>  31597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31597
aagacuuuag cacuuucacu                                                   20


<210>  31598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31598
augcauuuca aagacuuuag                                                   20


<210>  31599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31599
ucuaugcauu ucaaagacuu                                                   20


<210>  31600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31600
cuguuuggua gccgaggcgg                                                   20


<210>  31601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31601
gggccacuac cagucuccgu                                                   20


<210>  31602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31602
ucuaucucuu ugucuugugu                                                   20


<210>  31603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31603
aucucuuugu cuuguguccu                                                   20


<210>  31604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31604
gugaucucuc aucuccgcag                                                   20


<210>  31605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31605
ccucaccugc ggagaugaga                                                   20


<210>  31606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31606
ggucucagca cgucauucau                                                   20


<210>  31607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31607
uagguuacgg uguccucaug                                                   20


<210>  31608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31608
uucagcuucu gccauuccag                                                   20


<210>  31609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31609
gcuucugcca uuccaguuga                                                   20


<210>  31610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31610
gccauuccag uugaagagag                                                   20


<210>  31611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31611
aguugaagag agaccauuug                                                   20


<210>  31612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31612
acuggaaugg cagaagcuga                                                   20


<210>  31613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31613
agagauggcu gcaugcagac                                                   20


<210>  31614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31614
cucaaagguu uuaaaugucu                                                   20


<210>  31615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31615
uuaaucuccc acaacugaau                                                   20


<210>  31616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31616
guugugggag auuaaugaaa                                                   20


<210>  31617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31617
cccuaggcca caggugccag                                                   20


<210>  31618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31618
guuuagucaa uucuauuauu                                                   20


<210>  31619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31619
auuauuuagc auaccuuuca                                                   20


<210>  31620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31620
caagggaauu gaaagucugu                                                   20


<210>  31621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31621
cuugugaaag guaugcuaaa                                                   20


<210>  31622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31622
auucccuugu gaaagguaug                                                   20


<210>  31623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31623
gguuauggcc ucuuuuacuc                                                   20


<210>  31624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31624
augguuuaga guaaaagagg                                                   20


<210>  31625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31625
ggaagaguaa agcccuccug                                                   20


<210>  31626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31626
agaagggcau cacuuuucca                                                   20


<210>  31627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31627
cuccucuuaa cccacacuau                                                   20


<210>  31628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31628
guuucugacu gauuacaggc                                                   20


<210>  31629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31629
gacugauuac aggcaacaua                                                   20


<210>  31630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31630
caccuacacu ggaccuucau                                                   20


<210>  31631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31631
ucuuuuaucu aucaaaguau                                                   20


<210>  31632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31632
caaaugaaag uauaccccau                                                   20


<210>  31633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31633
uuugugaagg auuuugcagc                                                   20


<210>  31634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31634
uuucuauuau ucauagaggc                                                   20


<210>  31635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31635
auuauucaua gaggcauaag                                                   20


<210>  31636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31636
uagaggcaua agcaaggaac                                                   20


<210>  31637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31637
uugcuuaugc cucuaugaau                                                   20


<210>  31638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31638
aaccucaggu gauccgccca                                                   20


<210>  31639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31639
aaaccagccu ggccaacuug                                                   20


<210>  31640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31640
gaguagcugg uauuacaggu                                                   20


<210>  31641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31641
cauaccucag ccuuccgagu                                                   20


<210>  31642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31642
agcgauucuc auaccucagc                                                   20


<210>  31643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31643
uuuuuggaga uggagucuug                                                   20


<210>  31644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31644
acugucauga gacucucuuu                                                   20


<210>  31645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31645
caucaaggau gccaucuucu                                                   20


<210>  31646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31646
ggggagagac uuccuuggcu                                                   20


<210>  31647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31647
uuggcuuuac cuuaaagguu                                                   20


<210>  31648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31648
aaugggugua caguuccagg                                                   20


<210>  31649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31649
aggagugugg auggacccuu                                                   20


<210>  31650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31650
caguugugag auuaugaacc                                                   20


<210>  31651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31651
uaaucucaca acugagaagg                                                   20


<210>  31652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31652
agaucccuaa guuuuguugc                                                   20


<210>  31653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31653
cugauguucu cagaagaucc                                                   20


<210>  31654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31654
cagaagaucc agucuucggg                                                   20


<210>  31655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31655
gagaacauca gagaaagacu                                                   20


<210>  31656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31656
gguucuagaa ugcaaagggu                                                   20


<210>  31657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31657
agaaugcaaa ggguuugacc                                                   20


<210>  31658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31658
agaacccgaa gacuggaucu                                                   20


<210>  31659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31659
cugaggucaa acccuuugca                                                   20


<210>  31660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31660
augguucacu gaggucaaac                                                   20


<210>  31661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31661
ggguuguaua aaagcucucg                                                   20


<210>  31662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31662
augcauguuu uccggguugu                                                   20


<210>  31663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31663
aucgucauuu ucaaugcaug                                                   20


<210>  31664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31664
aucucaaaaa aaaaaaagug                                                   20


<210>  31665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31665
augaugaguc acgaaaugca                                                   20


<210>  31666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31666
ugacucauca uggaaaagau                                                   20


<210>  31667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31667
gcauuucgug acucaucaug                                                   20


<210>  31668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31668
ugaguccuua aagcuuuugu                                                   20


<210>  31669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31669
ccgugagucc auacuuaauu                                                   20


<210>  31670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31670
guccucuuga aucccaguug                                                   20


<210>  31671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31671
agaggacuga agucuaaugu                                                   20


<210>  31672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31672
ccaaauuagg ugcauugcac                                                   20


<210>  31673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31673
uucaaauugu auaucugaac                                                   20


<210>  31674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31674
aauuguauau cugaacuauu                                                   20


<210>  31675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31675
gauauacaau uugaaugaaa                                                   20


<210>  31676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31676
gugucagcug auuuaagaug                                                   20


<210>  31677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31677
ucuuaaauca gcugacacug                                                   20


<210>  31678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31678
ugguauucaa uuaauuuuug                                                   20


<210>  31679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31679
auuaauuuuu guucuacuug                                                   20


<210>  31680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31680
acuuggguua gcaguucuau                                                   20


<210>  31681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31681
auaagccagu cagucuuuuc                                                   20


<210>  31682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31682
uuaaaguucc aggaauucuu                                                   20


<210>  31683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31683
aggaauucuu acccaguuca                                                   20


<210>  31684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31684
uggaacuuua augaaaagac                                                   20


<210>  31685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31685
uacccaguuc aaaugauaug                                                   20


<210>  31686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31686
aaugauauga uucuaaaguu                                                   20


<210>  31687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31687
aaaguuauua gaaaccugua                                                   20


<210>  31688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31688
aauaacuuua gaaucauauc                                                   20


<210>  31689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31689
aagacugauu uuuagggucc                                                   20


<210>  31690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31690
uccuuuuaug aaucuccuaa                                                   20


<210>  31691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31691
uaaaaggaug aaaaggaccc                                                   20


<210>  31692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31692
aaaguauggu gucuuuuagg                                                   20


<210>  31693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31693
gaaaccgcac cagcauuaag                                                   20


<210>  31694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31694
gaaaacuuca aaaguauggu                                                   20


<210>  31695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31695
acaguuaauu gcuuaaugcu                                                   20


<210>  31696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31696
uugucaauug uguuuuuaac                                                   20


<210>  31697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31697
augauuuaca guaacuuaac                                                   20


<210>  31698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31698
aauaugccug agucuaugcu                                                   20


<210>  31699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31699
aaaauucuaa uaugccugag                                                   20


<210>  31700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31700
aaaauuaaau gggauuucua                                                   20


<210>  31701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31701
cuaaaaugua accugaagag                                                   20


<210>  31702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31702
gguuacauuu uagugaauga                                                   20


<210>  31703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31703
cauguaacuu aacauaucag                                                   20


<210>  31704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31704
gaccucuaac uuuggggugu                                                   20


<210>  31705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31705
aaauagucuu ucugaccucu                                                   20


<210>  31706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31706
gcuucaaaau agucuuucug                                                   20


<210>  31707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31707
caaaaucaaa uuucagcuuc                                                   20


<210>  31708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31708
uauaaaccuu uuauaauccc                                                   20


<210>  31709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31709
uucuuguugc ccaggcugga                                                   20


<210>  31710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31710
uguugcccag gcuggaguac                                                   20


<210>  31711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31711
aguaauucuc cugccucagc                                                   20


<210>  31712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31712
ccugccucag ccucucuagu                                                   20


<210>  31713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31713
ccacguuggu caggcugguc                                                   20


<210>  31714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31714
agaccagccu gaccaacgug                                                   20


<210>  31715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31715
augaaacaaa aaaagaucau                                                   20


<210>  31716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31716
uugaaccaca ggcaaaagcc                                                   20


<210>  31717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31717
uuuaugaugu ggcuuggccc                                                   20


<210>  31718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31718
cugaguagcc cuagugaccc                                                   20


<210>  31719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31719
cuuucccuga guagcccuag                                                   20


<210>  31720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31720
ggauucccuu ucccugagua                                                   20


<210>  31721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31721
uacccuuuug cugugugcca                                                   20


<210>  31722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31722
uaccagucag auuucugacc                                                   20


<210>  31723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31723
gaccucucuc ucucugugug                                                   20


<210>  31724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31724
aacugguuga augaauuaaa                                                   20


<210>  31725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31725
accaguuuga acacacagag                                                   20


<210>  31726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31726
uucaaccagu uugaacacac                                                   20


<210>  31727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31727
auuaaucaaa acuuuacaga                                                   20


<210>  31728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31728
cuacagccug agauuagccu                                                   20


<210>  31729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31729
cgugcuguuc ugugauaaaa                                                   20


<210>  31730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31730
gugauaaaaa ggggcgccuu                                                   20


<210>  31731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31731
auccuaaggc gccccuuuuu                                                   20


<210>  31732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31732
gggaucugca gcaguuacug                                                   20


<210>  31733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31733
aaguggaaca ggaauuuugg                                                   20


<210>  31734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31734
acuuggaagg uggagaccaa                                                   20


<210>  31735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31735
uguuccacuu ggaaggugga                                                   20


<210>  31736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31736
ugucauaguu agcucuacaa                                                   20


<210>  31737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31737
gcuggcaaag ccucguaacu                                                   20


<210>  31738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31738
gggaagggca auggagacug                                                   20


<210>  31739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31739
cagaaagagu cuagaguagu                                                   20


<210>  31740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31740
guggugaucu ggguuugauu                                                   20


<210>  31741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31741
uggcuuaggg aaugaguacu                                                   20


<210>  31742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31742
cuaagccagg aaucaaaccc                                                   20


<210>  31743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31743
aauugauauu uggguaaccu                                                   20


<210>  31744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31744
cccccuccac aaacugucuu                                                   20


<210>  31745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31745
agacaguuug uggaggggga                                                   20


<210>  31746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31746
cagagcaccu gggagguuac                                                   20


<210>  31747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31747
auaguuuaaa ggcaggaaua                                                   20


<210>  31748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31748
ugccuuuaaa cuauugaaag                                                   20


<210>  31749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31749
ucaggccaaa cagccaauau                                                   20


<210>  31750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31750
uuuaaauugc uuauuaccca                                                   20


<210>  31751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31751
ggcucuaaca gccugggacu                                                   20


<210>  31752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31752
caaggagucc caggcuguua                                                   20


<210>  31753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31753
caaaacgggg ucucuggcac                                                   20


<210>  31754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31754
ugaguaaaac agaguuuuuu                                                   20


<210>  31755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31755
gggguuucau gaguaaaaca                                                   20


<210>  31756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31756
aauuucuggg guuucaugag                                                   20


<210>  31757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31757
uuucaaaauc uaaggcucug                                                   20


<210>  31758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31758
aaaucuaagg cucuguucug                                                   20


<210>  31759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31759
guuuugcauu ggauuaucua                                                   20


<210>  31760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31760
gauaccccca aguaaaaaac                                                   20


<210>  31761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31761
cauagagacu ugguguguaa                                                   20


<210>  31762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31762
ugccuaguua uuacacacca                                                   20


<210>  31763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31763
agaccagccu gggcaacaug                                                   20


<210>  31764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31764
ccauguugcc caggcugguc                                                   20


<210>  31765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31765
gccucagccu cccaaauagc                                                   20


<210>  31766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31766
ucugccucag ccucccaaau                                                   20


<210>  31767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31767
cugcaaccuc cgccuccugg                                                   20


<210>  31768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31768
agcugugccu gcuuauuaua                                                   20


<210>  31769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31769
agggccuaau auaauaagca                                                   20


<210>  31770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31770
ugguccuguu cuuccaagga                                                   20


<210>  31771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31771
uccaaggacu ccauccuaaa                                                   20


<210>  31772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31772
aaggacucca uccuaaagcc                                                   20


<210>  31773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31773
aaauuggauu acuggcuuua                                                   20


<210>  31774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31774
aaguuucuaa auuggauuac                                                   20


<210>  31775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31775
uuuaccacuu ucuaaguuuc                                                   20


<210>  31776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31776
ucugucuguc uguguaguua                                                   20


<210>  31777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31777
gucugucugu guaguuauau                                                   20


<210>  31778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31778
agaccagccu ggccaaccag                                                   20


<210>  31779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31779
ccugguuggc caggcugguc                                                   20


<210>  31780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31780
ccugccucag ccuccugagu                                                   20


<210>  31781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31781
agugauucuc cugccucagc                                                   20


<210>  31782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31782
uaaagccaau uaauuagagc                                                   20


<210>  31783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31783
aaauauuuga uuuaagcacu                                                   20


<210>  31784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31784
uucaaaauau uugauuuaag                                                   20


<210>  31785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31785
guaaucuuug ggaaauaaaa                                                   20


<210>  31786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31786
caaagauuac ugaaguuaca                                                   20


<210>  31787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31787
ccaguaaccu uuaaaacuuu                                                   20


<210>  31788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31788
uuuuuuuuuu uuuuuuugag                                                   20


<210>  31789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31789
cucuuguugc ccaggcugga                                                   20


<210>  31790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31790
agcaauucuc cugccucagc                                                   20


<210>  31791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31791
ccugccucag ccucccgagu                                                   20


<210>  31792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31792
ccauguuggc caggcugguc                                                   20


<210>  31793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31793
agaccagccu ggccaacaug                                                   20


<210>  31794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31794
aaauuguuca aauuauuuug                                                   20


<210>  31795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31795
aauuauuuug gagcauuaga                                                   20


<210>  31796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31796
agauaaggcc ugcggacaug                                                   20


<210>  31797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31797
acauguccgc aggccuuauc                                                   20


<210>  31798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31798
uugccuagcu gggggcaugg                                                   20


<210>  31799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31799
uuguaaucuu cuuugccuag                                                   20


<210>  31800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31800
uauauaaaau uuauuuucuu                                                   20


<210>  31801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31801
ugcccuaaag uaaaauaacu                                                   20


<210>  31802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31802
cacuuguccu aaacacuccu                                                   20


<210>  31803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31803
caaauccuuu aacaacuuac                                                   20


<210>  31804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31804
ugcaccaaaa guaaaagaug                                                   20


<210>  31805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31805
auuacauguu auaaugguaa                                                   20


<210>  31806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31806
cucuccucac acaccuugca                                                   20


<210>  31807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31807
uauaaucuuu uaccaaaaac                                                   20


<210>  31808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31808
caugccuucu uauaaucuuu                                                   20


<210>  31809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31809
uuuacaagau uaauuuuuac                                                   20


<210>  31810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31810
gugugugaac auauugacua                                                   20


<210>  31811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31811
cacacagaau uucuuuuaca                                                   20


<210>  31812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31812
uuuuuuccag aaauugaaca                                                   20


<210>  31813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31813
agaaauugaa cauugaagua                                                   20


<210>  31814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31814
ggaaaaaaug aauaauacuc                                                   20


<210>  31815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31815
auuucuggaa aaaaugaaua                                                   20


<210>  31816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31816
auguucaauu ucuggaaaaa                                                   20


<210>  31817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31817
uuucuuucua uuuuuuuuuu                                                   20


<210>  31818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31818
uucuauuuuu uuuuuuugag                                                   20


<210>  31819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31819
auuuuuuuuu uuugagaugg                                                   20


<210>  31820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31820
ccugccucag ccucuggagu                                                   20


<210>  31821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31821
ccauauuggc caggcugguc                                                   20


<210>  31822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31822
agaccagccu ggccaauaug                                                   20


<210>  31823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31823
uaaagcacug uucugcucuu                                                   20


<210>  31824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31824
gcucuuucac aaaaauugua                                                   20


<210>  31825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31825
caaaaauugu aagggcuugg                                                   20


<210>  31826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31826
acugccucag ccuccugagu                                                   20


<210>  31827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31827
ugccauucua cugccucagc                                                   20


<210>  31828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31828
aagucagcca auuugugcug                                                   20


<210>  31829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31829
uuuuuaaaug caugucagug                                                   20


<210>  31830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31830
uucagaaugu uccacuguag                                                   20


<210>  31831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31831
gaauguucca cuguagucau                                                   20


<210>  31832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31832
gaaugaacaa cagugcacug                                                   20


<210>  31833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31833
acuguaguca ucuuuaguaa                                                   20


<210>  31834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31834
ccauuucugu aagacuucac                                                   20


<210>  31835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31835
guaagacuuc accacuuucc                                                   20


<210>  31836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31836
ccacuuucca ugccuaacgu                                                   20


<210>  31837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31837
augccuaacg uguaagccag                                                   20


<210>  31838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31838
ggcuuacacg uuaggcaugg                                                   20


<210>  31839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31839
uucuggcuua cacguuaggc                                                   20


<210>  31840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31840
ggaaauuaag gaacccauuu                                                   20


<210>  31841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31841
ggaaaacugg guuccuucug                                                   20


<210>  31842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31842
uuaauuuccg gaaaacuggg                                                   20


<210>  31843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31843
gguaaaaaug gguuccuuaa                                                   20


<210>  31844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31844
cuugauuaau uuagccaaug                                                   20


<210>  31845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31845
uaccuaagug ugcaagaaaa                                                   20


<210>  31846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31846
ugcacacuua gguaggaaaa                                                   20


<210>  31847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31847
uuuuucuugc acacuuaggu                                                   20


<210>  31848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31848
accccuuugu uucauuuuuc                                                   20


<210>  31849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31849
uggggauguu uguguucuac                                                   20


<210>  31850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31850
aaagccaaau uuuacacccc                                                   20


<210>  31851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31851
accaguuucu uucagaccca                                                   20


<210>  31852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31852
uucagaccca gucagaugua                                                   20


<210>  31853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31853
gacccaguca gauguaagag                                                   20


<210>  31854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31854
uggacccauc cauuuucuuu                                                   20


<210>  31855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31855
uuggcgacuu ccaaacccag                                                   20


<210>  31856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31856
aaacccaguu uggaucagaa                                                   20


<210>  31857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31857
gauccaaacu ggguuuggaa                                                   20


<210>  31858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31858
uugugcaaau uucugaucca                                                   20


<210>  31859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31859
agcucucuga guuuucuuug                                                   20


<210>  31860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31860
cagagcagcu ggggaucaug                                                   20


<210>  31861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31861
cucagugccc caggggucau                                                   20


<210>  31862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31862
aaugaccccu ggggcacuga                                                   20


<210>  31863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31863
gacaccaugu uaaaagaaaa                                                   20


<210>  31864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31864
uuuaacaugg ugucagaagu                                                   20


<210>  31865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31865
gccgaauuaa auuuaaagga                                                   20


<210>  31866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31866
gcugaaguuu uucuuuuaac                                                   20


<210>  31867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31867
uugcuuaauu aaacuccuuu                                                   20


<210>  31868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31868
ugaauugggc aguccucaga                                                   20


<210>  31869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31869
cgaaucauuc auugcuuaau                                                   20


<210>  31870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31870
gaggacugcc caauucacga                                                   20


<210>  31871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31871
gagagacucc agggaugcuu                                                   20


<210>  31872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31872
uggucagaac aaauuuacag                                                   20


<210>  31873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31873
gaccaugaag caucccugga                                                   20


<210>  31874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31874
cguuuuuugu cuguaaauuu                                                   20


<210>  31875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31875
guacgucacu ucccguuuuu                                                   20


<210>  31876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31876
guaccucacc uccaauuucu                                                   20


<210>  31877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31877
aaugaggcaa augccgagcu                                                   20


<210>  31878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31878
cucauacacu gcugagaguu                                                   20


<210>  31879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31879
aucuugucua ccuauaaguu                                                   20


<210>  31880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31880
uccacaaaga cucaaauaca                                                   20


<210>  31881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31881
guauuugagu cuuuguggau                                                   20


<210>  31882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31882
caggccauau uuaguuugcu                                                   20


<210>  31883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31883
gaaaauuuag aacaauuucc                                                   20


<210>  31884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31884
gaagggcagu uuggucauau                                                   20


<210>  31885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31885
aaauuuucag aagggcaguu                                                   20


<210>  31886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31886
ccuuucacca aaaacguauu                                                   20


<210>  31887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31887
ccaaaaacgu auuauaaugc                                                   20


<210>  31888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31888
ccaaaaauca gguuuuucuu                                                   20


<210>  31889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31889
uuuggcaaac aauuucacca                                                   20


<210>  31890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31890
ccagaaacua gguauuuccu                                                   20


<210>  31891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31891
ggugaaauug uuugccaaaa                                                   20


<210>  31892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31892
uuuucuuuuc uuucuuuuaa                                                   20


<210>  31893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31893
uuucuuucuu uuaaaauuug                                                   20


<210>  31894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31894
uucuuuuaaa auuuguagua                                                   20


<210>  31895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31895
uuuaaaauuu guaguaaaau                                                   20


<210>  31896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31896
gaaacaaugu cauacaguca                                                   20


<210>  31897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31897
gaacccuaug cuuaaaaauc                                                   20


<210>  31898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31898
uucaaucagu uugcacaguu                                                   20


<210>  31899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31899
aucaguuugc acaguuaacu                                                   20


<210>  31900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31900
gcuuuacaag augcaaagag                                                   20


<210>  31901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31901
uggggacaga gcuucagcuu                                                   20


<210>  31902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31902
accagccccu ggcaauuacc                                                   20


<210>  31903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31903
gcccucuguu uuuaugaauu                                                   20


<210>  31904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31904
uaaaaacaga gggcagaaug                                                   20


<210>  31905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31905
acugagacag gagauguaga                                                   20


<210>  31906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31906
uuuucuuuuu uuuuugaggc                                                   20


<210>  31907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31907
uuuuuuuuug aggcagaguc                                                   20


<210>  31908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31908
agcaauacuc cugucucagc                                                   20


<210>  31909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31909
ccguguuggc caggaugguc                                                   20


<210>  31910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31910
ucuccugacc ucgugaucug                                                   20


<210>  31911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31911
cuuagcauaa ugaccucaag                                                   20


<210>  31912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31912
uccauguugu aguguguguc                                                   20


<210>  31913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31913
gacacacacu acaacaugga                                                   20


<210>  31914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31914
cuccuauuua aggccaaaac                                                   20


<210>  31915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31915
auuguacaua uguuacugga                                                   20


<210>  31916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31916
aguaacauau guacaaugga                                                   20


<210>  31917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31917
uggaucuugc ucaagaaaga                                                   20


<210>  31918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31918
ugagcaagau ccaagaaccc                                                   20


<210>  31919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31919
uucuugagca agauccaaga                                                   20


<210>  31920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31920
gacgagucca cagaauaaaa                                                   20


<210>  31921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31921
guggacucgu cugaauucuu                                                   20


<210>  31922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31922
uuuuauucug uggacucguc                                                   20


<210>  31923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31923
uaguaaacuu acuuucauuu                                                   20


<210>  31924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31924
uuggcuuucu uaguaaacuu                                                   20


<210>  31925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31925
cuauuccuug gcuuucuuag                                                   20


<210>  31926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31926
uuuuauuuau uuauuuauuu                                                   20


<210>  31927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31927
ugccauucuu cugccucagc                                                   20


<210>  31928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31928
ucugccucag ccuccugagu                                                   20


<210>  31929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31929
gccucagccu ccugaguagc                                                   20


<210>  31930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31930
ccauguuagc caggaugguc                                                   20


<210>  31931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31931
ugauuauaug cuaaacaaga                                                   20


<210>  31932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31932
ugaguuuucc gugaaagggg                                                   20


<210>  31933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31933
gugaaagggg ugggcaauuc                                                   20


<210>  31934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31934
cggaaaacuc augaauaauc                                                   20


<210>  31935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31935
cagaacugag gguuucuccc                                                   20


<210>  31936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31936
gggaauugcc caccccuuuc                                                   20


<210>  31937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31937
ccccuuuuua gaacauauag                                                   20


<210>  31938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31938
aaaaagggga gaaacccuca                                                   20


<210>  31939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31939
aggccaggca ugguggcuca                                                   20


<210>  31940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31940
ccauguuggu caagcugguc                                                   20


<210>  31941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31941
ccugccucag ccucccgagu                                                   20


<210>  31942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31942
agcgauucuc cugccucagc                                                   20


<210>  31943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31943
cggguucaag cgauucuccu                                                   20


<210>  31944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31944
uguugugcag gcuggagugc                                                   20


<210>  31945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31945
uucuuguugu gcaggcugga                                                   20


<210>  31946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31946
uuugagacag aguuucauuc                                                   20


<210>  31947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31947
auuuuuuuuu uuucuuuuga                                                   20


<210>  31948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31948
auauguugcc auggcaucag                                                   20


<210>  31949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31949
cacagcucau uauaagcuaa                                                   20


<210>  31950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31950
uugccaucuu gguuuuggug                                                   20


<210>  31951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31951
uuacugcaac cuguuuuauc                                                   20


<210>  31952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31952
uagucacagg augagguagg                                                   20


<210>  31953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31953
caggagguua ggcauucaua                                                   20


<210>  31954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31954
agaugaaguu guucugguuc                                                   20


<210>  31955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31955
ucuugaauag gggcggggua                                                   20


<210>  31956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31956
gguuccaacg ccucugacau                                                   20


<210>  31957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31957
aacgccucug acauauuagc                                                   20


<210>  31958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31958
uuuuuuuuuu uccuuuuaaa                                                   20


<210>  31959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31959
uuuuaaaugg ggucuugcuc                                                   20


<210>  31960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31960
agcgauucuc uugccucagc                                                   20


<210>  31961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31961
cuugccucag ccucccgagu                                                   20


<210>  31962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31962
ccauguugcc caggcugauc                                                   20


<210>  31963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31963
acuuguuaaa cugaaaacug                                                   20


<210>  31964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31964
guuuaacaag uggaaaugua                                                   20


<210>  31965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31965
cgggccaguu uucaguuuaa                                                   20


<210>  31966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31966
guacugccau ccuugcgucc                                                   20


<210>  31967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31967
ucugcaagga cgcaaggaug                                                   20


<210>  31968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31968
gucugccuac cuacuaugcu                                                   20


<210>  31969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31969
guaacaacag cugugucuca                                                   20


<210>  31970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31970
ugcagccaga cuucaaccac                                                   20


<210>  31971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31971
accacucaca ggccgcaaac                                                   20


<210>  31972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31972
aacuguguuc ggagaaggcg                                                   20


<210>  31973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31973
gagaaggcga auucaucugg                                                   20


<210>  31974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31974
ccgaacacag uuugaacagu                                                   20


<210>  31975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31975
ccuucuccga acacaguuug                                                   20


<210>  31976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31976
ucuggcuguu aacgugccuc                                                   20


<210>  31977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31977
gcuuucugug gccacuuucc                                                   20


<210>  31978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31978
guggccacuu ucccuuuucu                                                   20


<210>  31979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31979
cuuuucuguc cauaaauuug                                                   20


<210>  31980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31980
guccauaaau uugcuuugac                                                   20


<210>  31981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31981
gggagacucu agggaugcug                                                   20


<210>  31982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31982
gggaccugca ccauuuguga                                                   20


<210>  31983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31983
caaauggugc aggucccaga                                                   20


<210>  31984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31984
uugaucagcu aaacucuguu                                                   20


<210>  31985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31985
auucaauuug uuggaaguuu                                                   20


<210>  31986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31986
auuuguugga aguuuuuaac                                                   20


<210>  31987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31987
aacaaauuga auugaacaga                                                   20


<210>  31988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31988
aauuucucca cuuccucaua                                                   20


<210>  31989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31989
ccacuuccuc auaaauaagu                                                   20


<210>  31990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31990
ucauaaauaa gucauuuuaa                                                   20


<210>  31991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31991
guauuccaau auuuggaagu                                                   20


<210>  31992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31992
aauauuugga aguauuaaug                                                   20


<210>  31993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31993
aaauauugga auacugaaaa                                                   20


<210>  31994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31994
accaauuuuc uauuuuugga                                                   20


<210>  31995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31995
auuuuuggac auugagguug                                                   20


<210>  31996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31996
uuuuuuuuuu cuuuuuuuga                                                   20


<210>  31997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31997
uuuuuugaga cagagucucg                                                   20


<210>  31998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31998
ccauguuggu caggcugguc                                                   20


<210>  31999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  31999
ugauauuaau guugcuuuaa                                                   20


<210>  32000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32000
uucugucacc caggcuggag                                                   20


<210>  32001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32001
gucacccagg cuggaguuca                                                   20


<210>  32002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32002
guggcgugau cucagcucac                                                   20


<210>  32003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32003
agugauucuc cugcgucggu                                                   20


<210>  32004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32004
ccugcgucgg ucuccugagu                                                   20


<210>  32005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32005
ugggucuuuc gaugguuauu                                                   20


<210>  32006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32006
augguuauuu aauacuuccc                                                   20


<210>  32007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32007
cuacaguaau gcccugugcg                                                   20


<210>  32008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32008
ucacacuuag cauguacgca                                                   20


<210>  32009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32009
aaagauuuaa cugugccaac                                                   20


<210>  32010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32010
gaaaagugau aggaggucau                                                   20


<210>  32011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32011
gaagagugac uuggcaaugu                                                   20


<210>  32012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32012
uaaaauugcu augaccuccu                                                   20


<210>  32013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32013
acauuuccuu acuaaucucg                                                   20


<210>  32014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32014
uuacuaaucu cgguuggugu                                                   20


<210>  32015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32015
aucuuuccuc acacuuuucu                                                   20


<210>  32016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32016
ucacacuuuu cuuggguuuu                                                   20


<210>  32017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32017
uggguuuuuc cugaaucaug                                                   20


<210>  32018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32018
ugaaucauga gucuacuaca                                                   20


<210>  32019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32019
ggaaaaaccc aagaaaagug                                                   20


<210>  32020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32020
aaagaugcuu uaaaaugugu                                                   20


<210>  32021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32021
accucugaaa ccccaaaauu                                                   20


<210>  32022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32022
gagguggaag gaucacuuga                                                   20


<210>  32023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32023
caaauuuugg gguuucagag                                                   20


<210>  32024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32024
aaauuaaaug agaccuuucu                                                   20


<210>  32025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32025
uuuuaacucg uauaucauca                                                   20


<210>  32026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32026
uacccucagu aucugccuaa                                                   20


<210>  32027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32027
uuucaaugaa aagcagcccc                                                   20


<210>  32028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32028
augaaaagca gcccccaagc                                                   20


<210>  32029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32029
uugaaaagaa aaccuuaccg                                                   20


<210>  32030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32030
uuucuaacaa agagcagccu                                                   20


<210>  32031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32031
aacaaagagc agccuguaaa                                                   20


<210>  32032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32032
agcuugcuug uguaugucug                                                   20


<210>  32033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32033
ccugugcaag cuuccagcuu                                                   20


<210>  32034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32034
uauuggcaca gcugccagca                                                   20


<210>  32035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32035
cuuuccuugu caaccaugug                                                   20


<210>  32036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32036
uugucaacca ugugcacagu                                                   20


<210>  32037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32037
uugcaugcua uguaaacauu                                                   20


<210>  32038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32038
gccgcaggcu ggaagaccca                                                   20


<210>  32039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32039
agccugcggc agaauggaca                                                   20


<210>  32040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32040
uuuuucucuu ucuuucaccu                                                   20


<210>  32041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32041
cuuucuuuca ccuauuaaag                                                   20


<210>  32042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32042
uucaccuauu aaagcuccac                                                   20


<210>  32043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32043
ccuauuaaag cuccacucuu                                                   20


<210>  32044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32044
ugauuuccuu ggcaugaggc                                                   20


<210>  32045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32045
uuggcaugag gcaaugaacc                                                   20


<210>  32046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32046
uugccucaug ccaaggaaau                                                   20


<210>  32047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32047
gggguaauac ccaagguuca                                                   20


<210>  32048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32048
gugacacagc cucaggaaau                                                   20


<210>  32049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32049
ugaggcugug ucacugaagu                                                   20


<210>  32050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32050
caagaugguc ggggcacagc                                                   20


<210>  32051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32051
uauauguaag aaguacauug                                                   20


<210>  32052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32052
uacauauaug aauugacguc                                                   20


<210>  32053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32053
guccagaaag gcggggacaa                                                   20


<210>  32054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32054
ggacggaacc aauguacuuc                                                   20


<210>  32055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32055
aggucacagg uagacaaaug                                                   20


<210>  32056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32056
uuugaaucuc cgauaagccu                                                   20


<210>  32057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32057
aaagaaugca accauuuguc                                                   20


<210>  32058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32058
aaaggaggca aucagaauau                                                   20


<210>  32059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32059
gauugccucc uuuggaaagg                                                   20


<210>  32060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32060
ccauguuggc cgggcugcuc                                                   20


<210>  32061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32061
ccugccucag ccucccgagu                                                   20


<210>  32062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32062
agcuauucuc cugccucagc                                                   20


<210>  32063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32063
ggguucaagc uauucuccug                                                   20


<210>  32064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32064
uucuggguuc aagcuauucu                                                   20


<210>  32065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32065
cucuuguugc ccaggcugga                                                   20


<210>  32066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32066
gagauggagu uucacucuug                                                   20


<210>  32067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32067
caaagugcug ggauuacagg                                                   20


<210>  32068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32068
ucauguuagc caggaugguc                                                   20


<210>  32069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32069
ccugccucag ccugccgagu                                                   20


<210>  32070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32070
cgccauucuc cugccucagc                                                   20


<210>  32071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32071
cucucucuuu uuuuuuuuuu                                                   20


<210>  32072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32072
gcucacugag auagaugcau                                                   20


<210>  32073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32073
aagucauccu ucugcucacu                                                   20


<210>  32074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32074
auucaaaguc auccuucugc                                                   20


<210>  32075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32075
uagcuugaac uuccccuuua                                                   20


<210>  32076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32076
agcuaggaac ugcucccauu                                                   20


<210>  32077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32077
ccuuuagcuu cagugauuug                                                   20


<210>  32078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32078
gugauuuggg ggcucaaggu                                                   20


<210>  32079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32079
uuucacauac cucagccucc                                                   20


<210>  32080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32080
cauaccucag ccucccaagu                                                   20


<210>  32081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32081
uacaaaaaaa auaaaacauu                                                   20


<210>  32082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32082
ggaggcugag gcgggaggac                                                   20


<210>  32083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32083
aaguucccuc uccaaaaccu                                                   20


<210>  32084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32084
cucuccaaaa ccucaugguu                                                   20


<210>  32085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32085
cuguucucau ccccugcacc                                                   20


<210>  32086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32086
cauccccugc acccucccuu                                                   20


<210>  32087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32087
ccuggaguac ucaccuggcc                                                   20


<210>  32088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32088
auucuaggca cagcauguga                                                   20


<210>  32089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32089
aggcacagca ugugaugagc                                                   20


<210>  32090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32090
ccgccuugac agugagaaag                                                   20


<210>  32091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32091
cacugucaag gcggugaagc                                                   20


<210>  32092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32092
gcucauucuc gaagucucaa                                                   20


<210>  32093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32093
cgaagucuca aacuucacuu                                                   20


<210>  32094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32094
agaaugagcc gaagggagac                                                   20


<210>  32095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32095
cuucuccugu gcgcugauuc                                                   20


<210>  32096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32096
ccugugcgcu gauucugaau                                                   20


<210>  32097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32097
gaauucagcc cccguccaag                                                   20


<210>  32098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32098
gaaucagcgc acaggagaag                                                   20


<210>  32099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32099
gcccccgucc aagguccugg                                                   20


<210>  32100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32100
cuucugcuug gcguguuguu                                                   20


<210>  32101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32101
gcuuggcgug uuguucauca                                                   20


<210>  32102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32102
ucaccacugu gcacugcuga                                                   20


<210>  32103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32103
cuggaccucu gcuuuaucau                                                   20


<210>  32104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32104
aaugauaaag cagaggucca                                                   20


<210>  32105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32105
cacgacauuc cuuucacuuc                                                   20


<210>  32106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32106
uuucacuucu cacuuggaag                                                   20


<210>  32107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32107
cuucucacuu ggaagaugag                                                   20


<210>  32108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32108
cacuuggaag augagccgug                                                   20


<210>  32109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32109
aagugagaag ugaaaggaau                                                   20


<210>  32110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32110
ucacggcuca ucuuccaagu                                                   20


<210>  32111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32111
gcuugacuug agggccaagc                                                   20


<210>  32112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32112
uauuuaaaac cauggcuugc                                                   20


<210>  32113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32113
uucuuauuua aaaccauggc                                                   20


<210>  32114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32114
aaccuucauc uucuaguaag                                                   20


<210>  32115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32115
ucuucuagua aggaaacaag                                                   20


<210>  32116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32116
aguaaggaaa caagugggcu                                                   20


<210>  32117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32117
uuacuagaag augaagguua                                                   20


<210>  32118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32118
ugcucaggaa agaccuaugu                                                   20


<210>  32119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32119
ugagcaagaa cucuaaagcc                                                   20


<210>  32120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32120
ugauccuccu ccccaggcca                                                   20


<210>  32121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32121
ugacauucau agucuaguua                                                   20


<210>  32122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32122
uagucuaguu acacgauccc                                                   20


<210>  32123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32123
acugacccuu acagggaucg                                                   20


<210>  32124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32124
uuuguagcac uuacuucaac                                                   20


<210>  32125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32125
uucaugggga gggauaugga                                                   20


<210>  32126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32126
uggggaggga uauggaucag                                                   20


<210>  32127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32127
gucccgaggg aaagaaaguc                                                   20


<210>  32128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32128
cucgggacug aaacaccucu                                                   20


<210>  32129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32129
uucccucggg acugaaacac                                                   20


<210>  32130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32130
uguaggacga cagagauggc                                                   20


<210>  32131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32131
gagccccugg gggugcagua                                                   20


<210>  32132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32132
gcaugccugg ccagugcaga                                                   20


<210>  32133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32133
guucaguagc acuggacaga                                                   20


<210>  32134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32134
guagcacugg acagaaggcc                                                   20


<210>  32135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32135
guccagugcu acugaacaga                                                   20


<210>  32136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32136
ugagacagca ccauuucugg                                                   20


<210>  32137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32137
gggaagagag ucaccuggga                                                   20


<210>  32138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32138
cagaaauggu gcugucucaa                                                   20


<210>  32139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32139
ccuccaagcc ggagcguggc                                                   20


<210>  32140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32140
ugcagcagcc ccucucuuca                                                   20


<210>  32141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32141
uucuugcagc agccccucuc                                                   20


<210>  32142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32142
ugaccagccu gggcaacaca                                                   20


<210>  32143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32143
caccucagcc uccccaagcg                                                   20


<210>  32144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32144
ccaccauccc cuccauaaaa                                                   20


<210>  32145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32145
uaccacccac aaccuucacc                                                   20


<210>  32146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32146
uacuauuuca uaccacccac                                                   20


<210>  32147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32147
ugccacagag cuccuaaaau                                                   20


<210>  32148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32148
caggauuuua ggagcucugu                                                   20


<210>  32149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32149
ugggugagca ucuuuuguuc                                                   20


<210>  32150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32150
aaugagguga cucuuggugg                                                   20


<210>  32151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32151
cuccuaucca ggagccacca                                                   20


<210>  32152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32152
ggugauucac uccuauccag                                                   20


<210>  32153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32153
aacucuggcu ugaucuuucu                                                   20


<210>  32154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32154
gcuucuaacu cuggcuugau                                                   20


<210>  32155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32155
uguguuauag ccagcacuuu                                                   20


<210>  32156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32156
agugauucuc cugccucagc                                                   20


<210>  32157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32157
ccugccucag ccuccugagc                                                   20


<210>  32158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32158
ccauauuaac caggcuggcc                                                   20


<210>  32159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32159
uaaaagaauc aacuaacuaa                                                   20


<210>  32160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32160
uuuaagaaca augucuuuug                                                   20


<210>  32161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32161
uaauuagguu agauuuuuau                                                   20


<210>  32162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32162
aggggagaaa aaucauguaa                                                   20


<210>  32163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32163
ccccuugaaa uuaauuuuug                                                   20


<210>  32164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32164
cucuuuacau gauuuuucuc                                                   20


<210>  32165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32165
uuaucuuucu cucuuuacau                                                   20


<210>  32166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32166
gcaaaguauu cauuaucuuu                                                   20


<210>  32167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32167
uaaauuucug caaaguauuc                                                   20


<210>  32168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32168
uccaaguuuu auguuuaugu                                                   20


<210>  32169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32169
aggaaaacau aauuuaucaa                                                   20


<210>  32170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32170
uagaaaugca uuucauccaa                                                   20


<210>  32171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32171
auuuuacuug ugguuaguuu                                                   20


<210>  32172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32172
agagaagaag uaaaguuguc                                                   20


<210>  32173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32173
cuugaaaaua uccuauuuag                                                   20


<210>  32174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32174
ucucuugaaa auauccuauu                                                   20


<210>  32175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32175
aaaaaacacc aggcucaaac                                                   20


<210>  32176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32176
caugucagau uguuugagcc                                                   20


<210>  32177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32177
aaguuuuauu ugcucucuaa                                                   20


<210>  32178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32178
agcccauuca aaguuuuauu                                                   20


<210>  32179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32179
agacucuaga aaaacaaaac                                                   20


<210>  32180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32180
agagucugga auauuucaag                                                   20


<210>  32181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32181
caauucuuuu uauaaagcaa                                                   20


<210>  32182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32182
uuuuauaaag caaguauaaa                                                   20


<210>  32183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32183
uaccaaucuc uuuuaugaau                                                   20


<210>  32184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32184
uaaaagagau ugguaugaag                                                   20


<210>  32185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32185
gucugguaau acuuuauuaa                                                   20


<210>  32186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32186
auaaugcaug gaugguucaa                                                   20


<210>  32187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32187
auacaaggaa auucaguaac                                                   20


<210>  32188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32188
uuguauugaa ccauccaugc                                                   20


<210>  32189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32189
guaacacaau auaauagauc                                                   20


<210>  32190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32190
caugaucuau uauauugugu                                                   20


<210>  32191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32191
uuggguauau ucacaugauc                                                   20


<210>  32192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32192
uagaugcugu aaaggcauuu                                                   20


<210>  32193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32193
acaccuacuu uuuagguggu                                                   20


<210>  32194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32194
uuagcaugau aaaauauauu                                                   20


<210>  32195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32195
gggcugauaa auauauuuua                                                   20


<210>  32196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32196
cuccagcgug ugcccuuauc                                                   20


<210>  32197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32197
uaauuuuaac auuauucccu                                                   20


<210>  32198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32198
uucuucuuuu uuuuuuuuga                                                   20


<210>  32199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32199
ucuuuuuuuu uuuugagacg                                                   20


<210>  32200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32200
uuuuuuuuuu ugagacggag                                                   20


<210>  32201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32201
agcgauucuc cugccucagc                                                   20


<210>  32202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32202
ccugccucag ccucccgagu                                                   20


<210>  32203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32203
ccauguuggu caggcugguc                                                   20


<210>  32204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32204
agaccagccu gaccaacaug                                                   20


<210>  32205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32205
acauuauccu uaauacugau                                                   20


<210>  32206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32206
acuuauuaug gauuuaucua                                                   20


<210>  32207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32207
cagcuucaca agacaguauu                                                   20


<210>  32208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32208
caagacagua uuacguagca                                                   20


<210>  32209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32209
ccaggcuagu gaugugcuac                                                   20


<210>  32210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32210
acuuugaucu uuccccaggc                                                   20


<210>  32211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32211
aauuuucaac uuugaucuuu                                                   20


<210>  32212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32212
auugaaugug uacugcuuuu                                                   20


<210>  32213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32213
auggaaacca cacuucaaau                                                   20


<210>  32214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32214
acuaaaauuu uuugacuuga                                                   20


<210>  32215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32215
ggaggaacuu ccauguacau                                                   20


<210>  32216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32216
uccugaaaau aaagaugguc                                                   20


<210>  32217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32217
auguacauug augacggacg                                                   20


<210>  32218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32218
aucguccguc aucaauguac                                                   20


<210>  32219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32219
aucauccuaa ugaacauaau                                                   20


<210>  32220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32220
uuaggaugau agaaacggau                                                   20


<210>  32221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32221
uuauguucau uaggaugaua                                                   20


<210>  32222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32222
gggcuggaag ccagaagagg                                                   20


<210>  32223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32223
agccccgaaa gcugcuuacu                                                   20


<210>  32224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32224
ggcuuccagc cccgaaagcu                                                   20


<210>  32225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32225
gcuuugcggg uauuugcuga                                                   20


<210>  32226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32226
agauaccuug uccagaucag                                                   20


<210>  32227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32227
agcgauucuc cugccucagc                                                   20


<210>  32228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32228
ccugccucag ccucccgagu                                                   20


<210>  32229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32229
ccauguuggc caggaugguc                                                   20


<210>  32230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32230
uuuuuagucc ccuaugcuca                                                   20


<210>  32231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32231
uuuccacuuu gggguccacu                                                   20


<210>  32232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32232
acuuuggggu ccacuuuggg                                                   20


<210>  32233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32233
uggguggggu ggaccccaaa                                                   20


<210>  32234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32234
ucuugggugg gguggacccc                                                   20


<210>  32235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32235
aagucauccu ucuucuuggg                                                   20


<210>  32236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32236
gagcugguuu acuuccaagu                                                   20


<210>  32237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32237
uaucaaccac auccaguucc                                                   20


<210>  32238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32238
ucaaaacugg aacuuggauu                                                   20


<210>  32239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32239
aguuuugagg aacuggaugu                                                   20


<210>  32240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32240
agugucccag gagccuggca                                                   20


<210>  32241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32241
ggagaggauu uuuguuugca                                                   20


<210>  32242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32242
uccggagagg auuuuuguuu                                                   20


<210>  32243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32243
aaugacucuc uaauaaauuu                                                   20


<210>  32244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32244
aauacaaugu ccagcacaca                                                   20


<210>  32245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32245
ugguaauuug uguuugugug                                                   20


<210>  32246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32246
cauccaucag gccucauauc                                                   20


<210>  32247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32247
gcuaauuccc auccaucagg                                                   20


<210>  32248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32248
ggcaugagaa acauacccuc                                                   20


<210>  32249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32249
caugccugaa guuucugcua                                                   20


<210>  32250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32250
aggccucuga ggguauguuu                                                   20


<210>  32251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32251
uaucuccauu aucuagacac                                                   20


<210>  32252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32252
cauguucaaa gaggaaauuu                                                   20


<210>  32253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32253
aagaggaaau uugcaaaacu                                                   20


<210>  32254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32254
ucuuugaaca ugggaaacau                                                   20


<210>  32255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32255
aguuuugcaa auuuccucuu                                                   20


<210>  32256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32256
ugccaacacu uucaaguuuu                                                   20


<210>  32257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32257
gauuuccugc caacacuuuc                                                   20


<210>  32258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32258
ggaccguaau uuauacugac                                                   20


<210>  32259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32259
gcaguuuucg ggaccguaau                                                   20


<210>  32260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32260
agaacuuaau gguaaagcaa                                                   20


<210>  32261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32261
ggaauucugc aguuuucggg                                                   20


<210>  32262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32262
gcuguuaaac ccuugcuuua                                                   20


<210>  32263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32263
auucugcugu uaaacccuug                                                   20


<210>  32264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32264
cucuggcuau uucuauucug                                                   20


<210>  32265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32265
uaguucucuc uggcuauuuc                                                   20


<210>  32266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32266
ggguaguguc aucugacuua                                                   20


<210>  32267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32267
uuggccucuc agugccuuau                                                   20


<210>  32268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32268
auuccuuggc cucucagugc                                                   20


<210>  32269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32269
gcauuuucca uuccuuggcc                                                   20


<210>  32270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32270
ucugcauuuu ccauuccuug                                                   20


<210>  32271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32271
cucucucccu gguacuccaa                                                   20


<210>  32272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32272
ccuucucucu cucccuggua                                                   20


<210>  32273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32273
ucuccuucuc ucucucccug                                                   20


<210>  32274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32274
guucuucucc uucucucucu                                                   20


<210>  32275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32275
aggacgguga cugagaggcu                                                   20


<210>  32276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32276
aaacugauga aagccaucag                                                   20


<210>  32277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32277
aagccucuca gucaccgucc                                                   20


<210>  32278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32278
ucaguuucga agccucucag                                                   20


<210>  32279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32279
caaauucaaa gcccagugaa                                                   20


<210>  32280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32280
aagcccagug aauuccaagg                                                   20


<210>  32281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32281
cugggcuuug aauuugugaa                                                   20


<210>  32282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32282
aaggagaaaa aaagaaaucc                                                   20


<210>  32283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32283
ccuuggaauu cacugggcuu                                                   20


<210>  32284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32284
uuuuuucucc uuggaauuca                                                   20


<210>  32285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32285
caguauggau uucuuuuuuu                                                   20


<210>  32286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32286
gauaacccuc ugccucugag                                                   20


<210>  32287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32287
cucccaaguu cucaucaucc                                                   20


<210>  32288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32288
caucauccca gggccaggga                                                   20


<210>  32289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32289
cuaggagagg gaucuggcuu                                                   20


<210>  32290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32290
ugucauucug gguauuugua                                                   20


<210>  32291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32291
ggguauuugu agggaaauug                                                   20


<210>  32292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32292
cuacaaauac ccagaaugac                                                   20


<210>  32293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32293
aauuucccua caaauaccca                                                   20


<210>  32294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32294
cuuccaauuu cccuacaaau                                                   20


<210>  32295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32295
ggcugugggg aaugucuuug                                                   20


<210>  32296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32296
ccacagccug aaaucuccca                                                   20


<210>  32297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32297
ccagcaaaga cauuccccac                                                   20


<210>  32298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32298
uuucaccagc aaagacauuc                                                   20


<210>  32299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32299
aaggucagga uguucuuuuc                                                   20


<210>  32300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32300
ccgaggggga ucugcguucc                                                   20


<210>  32301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32301
agaacuucug gagcugguau                                                   20


<210>  32302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32302
ggaacgcaga ucccccucgg                                                   20


<210>  32303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32303
ggagcuggua uagguaaggc                                                   20


<210>  32304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32304
uacugagcca gccuguugcu                                                   20


<210>  32305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32305
guaguuuugc agugauacgu                                                   20


<210>  32306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32306
cugucuuugg uuuucuguag                                                   20


<210>  32307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32307
aagcagcagc caugaaauug                                                   20


<210>  32308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32308
uggcugcugc uuugaaacua                                                   20


<210>  32309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32309
ugcuguugag acaucagcug                                                   20


<210>  32310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32310
uucuugcugu ugagacauca                                                   20


<210>  32311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32311
acuuuucauu cuugcuguug                                                   20


<210>  32312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32312
ccauguuagc caggaugguc                                                   20


<210>  32313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32313
ccugccucag ccucccgagu                                                   20


<210>  32314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32314
cgccauucuc cugccucagc                                                   20


<210>  32315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32315
ucacccuuuu uuuuuuuuuu                                                   20


<210>  32316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32316
aucuccugaa aggaagcaac                                                   20


<210>  32317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32317
ggagauugaa gcuucgucac                                                   20


<210>  32318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32318
uuucaggaga uugaagcuuc                                                   20


<210>  32319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32319
auacccacca aaauccguga                                                   20


<210>  32320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32320
cggauuuugg uggguaucga                                                   20


<210>  32321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32321
ucacggauuu ugguggguau                                                   20


<210>  32322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32322
uucuucacgg auuuuggugg                                                   20


<210>  32323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32323
ugauugaacu ggaaagauuu                                                   20


<210>  32324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32324
aucaggaagu guuuuuauuu                                                   20


<210>  32325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32325
aguucaauca ggaaguguuu                                                   20


<210>  32326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32326
gcaauagaag acccacuguc                                                   20


<210>  32327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32327
auugcggaaa ucuuuccagu                                                   20


<210>  32328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32328
uuggacagug ggucuucuau                                                   20


<210>  32329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32329
aaaggaugcu uuccaggcag                                                   20


<210>  32330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32330
aggcagaaga aaaugacccc                                                   20


<210>  32331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32331
gccuggaaag cauccuuuag                                                   20


<210>  32332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32332
ucugccugga aagcauccuu                                                   20


<210>  32333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32333
ucugggguca uuuucuucug                                                   20


<210>  32334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32334
ggaaagaaau ggagagugau                                                   20


<210>  32335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32335
ugaaucucug aucuuccucu                                                   20


<210>  32336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32336
uuccugaauc ucugaucuuc                                                   20


<210>  32337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32337
auuuuuauca cucuccauuu                                                   20


<210>  32338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32338
ggggccaauu uaaacaaaag                                                   20


<210>  32339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32339
cacucugucg cccaggcuac                                                   20


<210>  32340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32340
cuguagccug ggcgacagag                                                   20


<210>  32341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32341
cuugccucag ccuccugagu                                                   20


<210>  32342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32342
ccauguuggc caggcugguc                                                   20


<210>  32343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32343
agaccagccu ggccaacaug                                                   20


<210>  32344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32344
auauaaacac acacauaggc                                                   20


<210>  32345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32345
cccaauuugg aggguauuau                                                   20


<210>  32346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32346
ugauuaugca gggagcuuac                                                   20


<210>  32347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32347
cuucuugauu augcagggag                                                   20


<210>  32348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32348
uccuccaggu aucaaaaucu                                                   20


<210>  32349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32349
agggugacca ugaaaagagg                                                   20


<210>  32350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32350
uggucacccu agaaauuaca                                                   20


<210>  32351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32351
ggccauccuc ccaccuaggc                                                   20


<210>  32352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32352
ccauguuggc caggcugguc                                                   20


<210>  32353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32353
agaccagccu ggccaacaug                                                   20


<210>  32354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32354
aacuaacaga gguucaaaaa                                                   20


<210>  32355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32355
aaaauaaaau cagacuuaac                                                   20


<210>  32356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32356
guauauccua ccagcucugu                                                   20


<210>  32357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32357
uuaauauuaa cuguaaucgu                                                   20


<210>  32358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32358
uucauuaaua uuaacuguaa                                                   20


<210>  32359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32359
uauguggggu cuuugacaac                                                   20


<210>  32360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32360
aggugcaccg cugguaagga                                                   20


<210>  32361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32361
uuagguucua ggugcaccgc                                                   20


<210>  32362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32362
ucuguccugu uuccuuaggu                                                   20


<210>  32363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32363
cgucucauag gauggcugag                                                   20


<210>  32364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32364
gucugcagcu gggcccgugc                                                   20


<210>  32365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32365
ucucuggaag guuccugccu                                                   20


<210>  32366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32366
cuggaagguu ccugccuguu                                                   20


<210>  32367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32367
agagaagaaa gccaggagcu                                                   20


<210>  32368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32368
ugccuguuuu gcccucacac                                                   20


<210>  32369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32369
cccugggguc ugcgucaggg                                                   20


<210>  32370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32370
uucuuuucca gccccacccc                                                   20


<210>  32371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32371
uuuccagccc caccccgcgu                                                   20


<210>  32372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32372
agccccaccc cgcgugcauc                                                   20


<210>  32373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32373
aggccucuuc ucucuucucg                                                   20


<210>  32374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32374
cucuucucgg caggacaggc                                                   20


<210>  32375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32375
cggcaggaca ggcacaggca                                                   20


<210>  32376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32376
uucauuuaac aaucuucccc                                                   20


<210>  32377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32377
uuuaacaauc uuccccugaa                                                   20


<210>  32378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32378
ccugaauagu ucauguucau                                                   20


<210>  32379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32379
ggggaagauu guuaaaugaa                                                   20


<210>  32380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32380
uguucauugc ugaaaauuug                                                   20


<210>  32381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32381
uugcugaaaa uuugaaaaau                                                   20


<210>  32382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32382
gcaaugaaca ugaacuauuc                                                   20


<210>  32383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32383
aauuuucagc aaugaacaug                                                   20


<210>  32384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32384
auauuuuuca aauuuucagc                                                   20


<210>  32385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32385
ccugcccaga gagagucacu                                                   20


<210>  32386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32386
uagucaccaa gucauagcag                                                   20


<210>  32387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32387
cucucgcucu uuuuuuuuuu                                                   20


<210>  32388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32388
agcgauucuc cugccucagc                                                   20


<210>  32389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32389
ccugccucag ccucuugagu                                                   20


<210>  32390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32390
ucuuguuggu caggcggacu                                                   20


<210>  32391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32391
aguccgccug accaacaaga                                                   20


<210>  32392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32392
ucucucuucu guguaugugu                                                   20


<210>  32393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32393
guguaugugu acgcuguuuu                                                   20


<210>  32394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32394
uuagaauggg ggacguuauc                                                   20


<210>  32395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32395
aaagaaaaaa cagcguacac                                                   20


<210>  32396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32396
cugugucaca agugcucauc                                                   20


<210>  32397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32397
agaugagcac uugugacaca                                                   20


<210>  32398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32398
aaugacugcc uguggcuaug                                                   20


<210>  32399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32399
uuuaacucag cuccuucugc                                                   20


<210>  32400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32400
gcccagcauc uaucuuuuuu                                                   20


<210>  32401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32401
aucuuuuguc cuaaguguug                                                   20


<210>  32402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32402
cguaauuuau ccuaugcaaa                                                   20


<210>  32403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32403
gggacugugc ccauuuuuag                                                   20


<210>  32404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32404
gugaacuuua aaaaccugug                                                   20


<210>  32405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32405
cagaaaaguu uggcaucauc                                                   20


<210>  32406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32406
guaagucuuu cacauuagau                                                   20


<210>  32407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32407
cauuagauuu ccugucagga                                                   20


<210>  32408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32408
ugucaggaug auagucaauu                                                   20


<210>  32409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32409
aggcagauga uguuuucuca                                                   20


<210>  32410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32410
cagccauggc ugaagcaguu                                                   20


<210>  32411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32411
gccauggcug agaaaacauc                                                   20


<210>  32412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32412
aacccaucca gggaggcaau                                                   20


<210>  32413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32413
guuauaugcu cccaaaccaa                                                   20


<210>  32414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32414
gucugagcug cugugacucc                                                   20


<210>  32415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32415
cccuuacaga ugaaagaauu                                                   20


<210>  32416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32416
ucuguaaggg agaaauacac                                                   20


<210>  32417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32417
uucaucugua agggagaaau                                                   20


<210>  32418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32418
aggccaggcu ggaaugacaa                                                   20


<210>  32419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32419
agccuggccu ggaauucuuu                                                   20


<210>  32420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32420
agcucccauc accccaggau                                                   20


<210>  32421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32421
agggagcagg aaaaaggugu                                                   20


<210>  32422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32422
ugcucccugg aaugggaugu                                                   20


<210>  32423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32423
cuucauuuua ugugauuccu                                                   20


<210>  32424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32424
uuuuauguga uuccuuucua                                                   20


<210>  32425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32425
uuucuagaag uacuacucau                                                   20


<210>  32426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32426
agaaguacua cucauuacuu                                                   20


<210>  32427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32427
agaaaggaau cacauaaaau                                                   20


<210>  32428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32428
gcuugcaucu cccuggcuag                                                   20


<210>  32429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32429
gcuagcuaug gccauauaac                                                   20


<210>  32430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32430
uucagcuagc uauggccaua                                                   20


<210>  32431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32431
uuagagaccu uuuuaucuaa                                                   20


<210>  32432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32432
ucccauaaca auaaguaaua                                                   20


<210>  32433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32433
gguugauguc cuaagcccca                                                   20


<210>  32434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32434
ggggcuuagg acaucaaccu                                                   20


<210>  32435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32435
gagguucugg ggcuuaggac                                                   20


<210>  32436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32436
uuaaggaggu aaggaggcua                                                   20


<210>  32437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32437
uguaagacau cagucggauu                                                   20


<210>  32438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32438
ugguguccuc acguggccgu                                                   20


<210>  32439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32439
ccugagcccu guccuugacu                                                   20


<210>  32440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32440
ucucggacuu cuagccucua                                                   20


<210>  32441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32441
agccucuagg accaugagaa                                                   20


<210>  32442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32442
caugguccua gaggcuagaa                                                   20


<210>  32443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32443
guuguuuaag cugcccgguc                                                   20


<210>  32444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32444
agcagcagau gacuguauuu                                                   20


<210>  32445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32445
gugggucagg aauuuggacc                                                   20


<210>  32446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32446
ugacccacag aacgugugac                                                   20


<210>  32447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32447
cgccaggguu cagucaaaua                                                   20


<210>  32448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32448
gucaaauacc agcugccucc                                                   20


<210>  32449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32449
ccggcugagc ucucaggugg                                                   20


<210>  32450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32450
aaucucacgu gguguuggca                                                   20


<210>  32451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32451
ucauggccug cuggacugag                                                   20


<210>  32452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32452
caguccagca ggccaugagg                                                   20


<210>  32453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32453
cacugccugu uggccagagg                                                   20


<210>  32454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32454
ucagagcauc caugccaaga                                                   20


<210>  32455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32455
uggcauggau gcucugauga                                                   20


<210>  32456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32456
gucucccugg cccucucugu                                                   20


<210>  32457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32457
aucaccuuug cccauugguu                                                   20


<210>  32458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32458
aaccaauggg caaaggugau                                                   20


<210>  32459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32459
cugcuguuaa uaagggccuu                                                   20


<210>  32460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32460
caguucucug cuguuaauaa                                                   20


<210>  32461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32461
agcaauucug ccucagccuc                                                   20


<210>  32462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32462
gccucagccu ccggaauagc                                                   20


<210>  32463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32463
ggaggcugag gcagaauugc                                                   20


<210>  32464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32464
ccauguuggc caggcugguc                                                   20


<210>  32465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32465
agaccagccu ggccaacaug                                                   20


<210>  32466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32466
agcgaggugc gguggcucac                                                   20


<210>  32467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32467
uggguucagg ugauccuccc                                                   20


<210>  32468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32468
ggugauccuc ccacaucagc                                                   20


<210>  32469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32469
ugggaggcug augugggagg                                                   20


<210>  32470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32470
caguucuugg gaggcugaug                                                   20


<210>  32471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32471
cugcuguccu ucucaagaaa                                                   20


<210>  32472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32472
caagaaaagg gaggcuacug                                                   20


<210>  32473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32473
ugagaaggac agcagagaaa                                                   20


<210>  32474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32474
cuuuaggaca ggcucugaga                                                   20


<210>  32475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32475
gcagcagcuc agcagagguc                                                   20


<210>  32476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32476
ggcaggaccc ccaaggggcg                                                   20


<210>  32477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32477
uuaugggagu gcaccccugc                                                   20


<210>  32478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32478
ugugggcggc aucuuguggc                                                   20


<210>  32479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32479
cgcugcacua aucacagugc                                                   20


<210>  32480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32480
ggggcgcugc gcugggaccg                                                   20


<210>  32481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32481
cugcgcucug cgcaggagcu                                                   20


<210>  32482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32482
gcaugggccu gcgcccgcgc                                                   20


<210>  32483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32483
ugggcgagcc ccuccauggc                                                   20


<210>  32484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32484
ugccccgccc ccagccuccc                                                   20


<210>  32485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32485
ucgucccgcc ucgccgcgac                                                   20


<210>  32486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32486
cacacagcuu cgccucaccc                                                   20


<210>  32487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32487
ccucacccca uuacagucuc                                                   20


<210>  32488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32488
cccggguggg gcgcugcgcu                                                   20


<210>  32489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32489
gccucacaca gcaaggccgc                                                   20


<210>  32490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32490
cuggccagcc auuggcagag                                                   20


<210>  32491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32491
gcuuuuaccu gcggcccaga                                                   20


<210>  32492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32492
uugccccggu gcugagcggc                                                   20


<210>  32493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32493
agggucgcca uggcggucuc                                                   20


<210>  32494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32494
ucagcuuuuc cagggucgcc                                                   20


<210>  32495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32495
agucccucaa guccuuccag                                                   20


<210>  32496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32496
agcagcagca gcagcagcag                                                   20


<210>  32497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32497
ucagccgccg ccgcaggcac                                                   20


<210>  32498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32498
ugucgccggc ccgcaggcug                                                   20


<210>  32499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32499
cccacuucag ccccgcuccc                                                   20


<210>  32500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32500
gccccgcucc cucacuuggg                                                   20


<210>  32501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32501
cuuguccucu cgcgagggga                                                   20


<210>  32502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32502
ggacaggccc caacaaggcu                                                   20


<210>  32503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32503
ccgaggggag ucacggccuc                                                   20


<210>  32504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32504
caggaugcga agaguugggg                                                   20


<210>  32505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32505
cauccugcga agggcgagag                                                   20


<210>  32506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32506
cgccccaacu cuucgcaucc                                                   20


<210>  32507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32507
uuuuauuugc gagaaaccag                                                   20


<210>  32508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32508
cgcaaauaaa aagaaacaag                                                   20


<210>  32509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32509
uuuaacugcg uugugaagag                                                   20


<210>  32510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32510
caacgcaguu aaaagaaccc                                                   20


<210>  32511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32511
cuucacaacg caguuaaaag                                                   20


<210>  32512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32512
cucuucuagu cugagaggga                                                   20


<210>  32513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32513
agucugagag ggaagagggc                                                   20


<210>  32514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32514
cucucagacu agaagaggga                                                   20


<210>  32515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32515
agaggaggcg ggguuuggag                                                   20


<210>  32516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32516
uuuccuagug gcacuuaaaa                                                   20


<210>  32517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32517
uaguggcacu uaaaacagcc                                                   20


<210>  32518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32518
uacauuguca ggacauuuca                                                   20


<210>  32519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32519
uuuaguucau gaucacggug                                                   20


<210>  32520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32520
ugaucacggu gguaguaaca                                                   20


<210>  32521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32521
aacgccugca gaccaacuua                                                   20


<210>  32522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32522
ccacuuuacu uggcaaccac                                                   20


<210>  32523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32523
uuaaucacca cguaaguuca                                                   20


<210>  32524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32524
uaauauuuaa gauaauuuca                                                   20


<210>  32525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32525
aucaacucuu ccuaauauuu                                                   20


<210>  32526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32526
caacacacau aggcaaaaaa                                                   20


<210>  32527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32527
ucccucggca auuaaccucc                                                   20


<210>  32528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32528
agucaggcuu gccagaauac                                                   20


<210>  32529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32529
ggcaagccug acuggaauac                                                   20


<210>  32530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32530
cuggcacauc ugagaugccc                                                   20


<210>  32531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32531
guuugcuuca uugcugacag                                                   20


<210>  32532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32532
uugcugacag cuuguuacuu                                                   20


<210>  32533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32533
aaaaaguaac aagcugucag                                                   20


<210>  32534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32534
guugcuuguu cuuggggaga                                                   20


<210>  32535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32535
uggggagaau uuuugaaaca                                                   20


<210>  32536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32536
ccccaagaac aagcaacaga                                                   20


<210>  32537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32537
aaaauucucc ccaagaacaa                                                   20


<210>  32538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32538
uguuucaaaa auucucccca                                                   20


<210>  32539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32539
gcuagauguu uuaauggucu                                                   20


<210>  32540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32540
cuggaagucu gugugucgag                                                   20


<210>  32541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32541
agggaaaguc cugggguucc                                                   20


<210>  32542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32542
uaacuccuac uguacacucg                                                   20


<210>  32543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32543
ggccuuucuc uuaccucuca                                                   20


<210>  32544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32544
cuuaccucuc aguauucuau                                                   20


<210>  32545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32545
auuuccgauc uggauguguc                                                   20


<210>  32546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32546
gaucuggaug ugucccagau                                                   20


<210>  32547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32547
uaccaaaugc caucugggac                                                   20


<210>  32548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32548
uguucuuugu uucuguuaug                                                   20


<210>  32549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32549
uuguuucugu uaugauccuu                                                   20


<210>  32550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32550
guuaugaucc uugucucguc                                                   20


<210>  32551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32551
aaguuuaauu agaaaaugau                                                   20


<210>  32552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32552
aauuaaacuu ugaagacgag                                                   20


<210>  32553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32553
gagagcagug uuagcuuauu                                                   20


<210>  32554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32554
aacaaauaag cuaacacugc                                                   20


<210>  32555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32555
uaaauuuuau uccaacaaau                                                   20


<210>  32556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32556
aaaggaugga aaaacuuuuu                                                   20


<210>  32557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32557
auccuuuaga auaauuuauu                                                   20


<210>  32558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32558
ccaaauaucc aaaaaguuuu                                                   20


<210>  32559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32559
guaaguaauu ucucauccag                                                   20


<210>  32560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32560
cauccagaaa uuuacuguag                                                   20


<210>  32561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32561
ggaugagaaa uuacuuacug                                                   20


<210>  32562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32562
aggagguagg ugucauaaaa                                                   20


<210>  32563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32563
cacauugcau guaucuugug                                                   20


<210>  32564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32564
caucaggagc ccuguuuagu                                                   20


<210>  32565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32565
uucccaucag gagcccuguu                                                   20


<210>  32566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32566
gcugggcugc uucagacacu                                                   20


<210>  32567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32567
gacacuugau cauucuaaaa                                                   20


<210>  32568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32568
aaaaauaugc cuucucuuuc                                                   20


<210>  32569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32569
cuuucuuaug cugauuugac                                                   20


<210>  32570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32570
uaugcugauu ugacagaacc                                                   20


<210>  32571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32571
gucaaaucag cauaagaaag                                                   20


<210>  32572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32572
aaauaugggu aucaagaaau                                                   20


<210>  32573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32573
ugauacccau auuuugaaga                                                   20


<210>  32574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32574
uuugcugccu ugacaaagga                                                   20


<210>  32575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32575
uuacuuuaag guaauauaug                                                   20


<210>  32576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32576
uccaccuagg ccucccaaag                                                   20


<210>  32577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32577
ccauguuagc caggcugguc                                                   20


<210>  32578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32578
ugccucagcc ucccagguag                                                   20


<210>  32579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32579
agcgauuuuc cugccucagc                                                   20


<210>  32580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32580
guaauuacaa aagggcaaua                                                   20


<210>  32581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32581
uuccaccccu uuccucugag                                                   20


<210>  32582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32582
accccuuucc ucugaguacc                                                   20


<210>  32583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32583
ucugaguacc uaacuuuguc                                                   20


<210>  32584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32584
uggggacaaa guuagguacu                                                   20


<210>  32585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32585
guuccucaug uauccugcca                                                   20


<210>  32586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32586
ucauguaucc ugccagauau                                                   20


<210>  32587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32587
uauuguaaga uagauuuaaa                                                   20


<210>  32588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32588
aaacuacuuu uguuuuuaga                                                   20


<210>  32589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32589
aaugcuucuc cugccucagc                                                   20


<210>  32590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32590
ccugccucag ccuucugagu                                                   20


<210>  32591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32591
gaguagcugg gauuacaggc                                                   20


<210>  32592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32592
ccauguuggc caggcugguc                                                   20


<210>  32593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32593
agaccagccu ggccaacaug                                                   20


<210>  32594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32594
agccaggcau gguggcucac                                                   20


<210>  32595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32595
uagcaugcuc ugaaaucaac                                                   20


<210>  32596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32596
gagcaugcua agaaccuuua                                                   20


<210>  32597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32597
cuguauuuug cuguugagaa                                                   20


<210>  32598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32598
caacagcaaa auacagagaa                                                   20


<210>  32599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32599
cuaauuuuga guaacaaaca                                                   20


<210>  32600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32600
guucacgugc uucagccaaa                                                   20


<210>  32601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32601
cgugcuucag ccaaaaaauc                                                   20


<210>  32602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32602
gccaaaaaau ccucuucuca                                                   20


<210>  32603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32603
caaaguaaga uugaugaaag                                                   20


<210>  32604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32604
ucaaucuuac uuugagaaga                                                   20


<210>  32605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32605
aaauugcuuu caucaaucuu                                                   20


<210>  32606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32606
guuuuuaugg cucuugcucu                                                   20


<210>  32607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32607
acaccaaaga gcaagagcca                                                   20


<210>  32608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32608
uuauggggcu ggcugcaggc                                                   20


<210>  32609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32609
ggcaguuucu uauucuccuu                                                   20


<210>  32610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32610
uauucuccuu cagauuccua                                                   20


<210>  32611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32611
ccuucagauu ccuaucuggu                                                   20


<210>  32612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32612
gauuccuauc ugguguuucc                                                   20


<210>  32613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32613
uaucuggugu uucccugacu                                                   20


<210>  32614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32614
cugacuuuau ucauucauca                                                   20


<210>  32615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32615
uucaucagua aauauuuacu                                                   20


<210>  32616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32616
ucaguaaaua uuuacuaaac                                                   20


<210>  32617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32617
cgagggcaga gcuuugucug                                                   20


<210>  32618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32618
uucuaaugaa ggacauagac                                                   20


<210>  32619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32619
aaugaaggac auagacagua                                                   20


<210>  32620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32620
uuagaaugaa agcuucacga                                                   20


<210>  32621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32621
uccacguauu aacguacugu                                                   20


<210>  32622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32622
aagcagggaa ggggauaggg                                                   20


<210>  32623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32623
cugcuuugaa guuccuccac                                                   20


<210>  32624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32624
cuauccccuu cccugcuuug                                                   20


<210>  32625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32625
agcaaaaccc agaaagccug                                                   20


<210>  32626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32626
ggguuuugcu ggaaagcccu                                                   20


<210>  32627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32627
aaaagagcug uagcacuaag                                                   20


<210>  32628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32628
ugcucuauca gccaggcugg                                                   20


<210>  32629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32629
agugauucuc augccucagc                                                   20


<210>  32630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32630
caugccucag ccuccuguuu                                                   20


<210>  32631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32631
cccgagacgg agucuugcuc                                                   20


<210>  32632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32632
cgaguucacg ccauucuccu                                                   20


<210>  32633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32633
cgccauucuc cugccucagu                                                   20


<210>  32634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32634
ccugccucag ucucccaagu                                                   20


<210>  32635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32635
ccguguuagc caggaugauc                                                   20


<210>  32636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32636
agaccagccu gcucaucaug                                                   20


<210>  32637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32637
gggaaggucc acugagaaga                                                   20


<210>  32638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32638
cugaacaccg uauuuaaaau                                                   20


<210>  32639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32639
caguggaccu ucccugaaca                                                   20


<210>  32640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32640
agccuggguu aaagagcaag                                                   20


<210>  32641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32641
gccuugaacu ccugggcuca                                                   20


<210>  32642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32642
aggcugaagu gagcuacgau                                                   20


<210>  32643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32643
uacacccuua cacuagacuc                                                   20


<210>  32644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32644
agaugggggg aacaggucca                                                   20


<210>  32645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32645
ccccaucugg aauaccacua                                                   20


<210>  32646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32646
uguuucagga auagcaagga                                                   20


<210>  32647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32647
ggaauagcaa ggaugucauu                                                   20


<210>  32648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32648
ugaaacagga agauuuugga                                                   20


<210>  32649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32649
cccaacuaaa augacauccu                                                   20


<210>  32650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32650
uacuacaaau gucccccuca                                                   20


<210>  32651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32651
aucuacaagg caaguaguau                                                   20


<210>  32652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32652
gaucaugcua cuccucugcu                                                   20


<210>  32653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32653
aucuuaagug aacucuggcu                                                   20


<210>  32654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32654
cuuaagauug aaauucagau                                                   20


<210>  32655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32655
cucuguuguc agccagaguu                                                   20


<210>  32656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32656
ccuucacucu guugucagcc                                                   20


<210>  32657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32657
gcuuuugccg guguuccccu                                                   20


<210>  32658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32658
uaacugguuu cugcuuuugc                                                   20


<210>  32659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32659
gucaggguac cggcugucgg                                                   20


<210>  32660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32660
ucacacugcc cacagccgac                                                   20


<210>  32661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32661
aaauccaguc agucauuccu                                                   20


<210>  32662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32662
gcauucaaaa uccagucagu                                                   20


<210>  32663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32663
acaagugcag uugguuccgc                                                   20


<210>  32664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32664
gcugcaagua acagaaaauc                                                   20


<210>  32665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32665
guuacuugca gcugaauaca                                                   20


<210>  32666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32666
gauaagcucu ugcuuguuac                                                   20


<210>  32667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32667
ccagacuuau uuuugucuuc                                                   20


<210>  32668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32668
acaauaaguu aaggaaccca                                                   20


<210>  32669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32669
uuaacuuauu guugaauuuc                                                   20


<210>  32670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32670
uuuuuuuuuu uuugaaacgg                                                   20


<210>  32671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32671
aaaaaaaaaa aaagaaagag                                                   20


<210>  32672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32672
cucuugucac ccgggcugga                                                   20


<210>  32673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32673
agugauucuu cugccucagc                                                   20


<210>  32674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32674
ucugccucag ccucccaagu                                                   20


<210>  32675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32675
gccucagccu cccaaguaac                                                   20


<210>  32676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32676
ccauguuggc caggcugguc                                                   20


<210>  32677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32677
agaccagccu ggccaacaug                                                   20


<210>  32678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32678
gaccucaggu gauccacucg                                                   20


<210>  32679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32679
gaccgggugc aguggcccaa                                                   20


<210>  32680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32680
uauacuuacc uugcaaaccc                                                   20


<210>  32681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32681
cauuuuuucc cuuuguauuu                                                   20


<210>  32682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32682
cuuuguauuu uuauuguuga                                                   20


<210>  32683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32683
acaauaaaaa uacaaaggga                                                   20


<210>  32684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32684
uuauauauuc uggauacugg                                                   20


<210>  32685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32685
ggauacugga uucuuaucag                                                   20


<210>  32686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32686
uaucagauag augauuugua                                                   20


<210>  32687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32687
uuuggauugu cuuuuuacuu                                                   20


<210>  32688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32688
ugauaguguc uuuugaagug                                                   20


<210>  32689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32689
aaagacacua ucaagaaagu                                                   20


<210>  32690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32690
ucaaaauuaa aaacuuuuac                                                   20


<210>  32691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32691
agugucauau cuaagaaauc                                                   20


<210>  32692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32692
uagauaugac acuugaagca                                                   20


<210>  32693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32693
ucuaagaauu uuagaguuuu                                                   20


<210>  32694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32694
aagaauuuua gaguuuuaca                                                   20


<210>  32695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32695
uagaagaaaa cauaggagua                                                   20


<210>  32696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32696
gguagaaguc caacuuuauu                                                   20


<210>  32697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32697
accugaacca uauauaaaaa                                                   20


<210>  32698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32698
uuuccaugug guuauucagu                                                   20


<210>  32699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32699
augugguuau ucaguugucc                                                   20


<210>  32700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32700
guugucccag cacuguuugu                                                   20


<210>  32701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32701
acaaacagug cugggacaac                                                   20


<210>  32702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32702
uuccccaugg aauuaucuua                                                   20


<210>  32703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32703
ccauggaauu aucuuaguac                                                   20


<210>  32704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32704
auggggaaag aauagucucu                                                   20


<210>  32705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32705
acaaggguac uaagauaauu                                                   20


<210>  32706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32706
agacugucag uucuaccugu                                                   20


<210>  32707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32707
accuguuggu cuuuaugucg                                                   20


<210>  32708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32708
guaaucaaga cuguauggua                                                   20


<210>  32709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32709
ugaaauguga guucuccaac                                                   20


<210>  32710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32710
ugaauuuaaa cugugacaca                                                   20


<210>  32711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32711
ccaacuuugu uccuuuucaa                                                   20


<210>  32712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32712
uuuucaagau ugauuuggcc                                                   20


<210>  32713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32713
agauugauuu ggccaugcug                                                   20


<210>  32714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32714
guacgaauug uaggaucagc                                                   20


<210>  32715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32715
uacggaaaug caagggaccc                                                   20


<210>  32716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32716
acaaagaagc caaguaggau                                                   20


<210>  32717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32717
uuguugaaac ugacaagcug                                                   20


<210>  32718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32718
gagagggauu guguugaauc                                                   20


<210>  32719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32719
acacaauccc ucucagaauc                                                   20


<210>  32720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32720
caucuuaaca auauugucuu                                                   20


<210>  32721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32721
accuaugaac augggcaaac                                                   20


<210>  32722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32722
uagguggaag acaauauugu                                                   20


<210>  32723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32723
ggcugugugg gcacaguguc                                                   20


<210>  32724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32724
ugcuacaaug gcagagccgc                                                   20


<210>  32725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32725
aauagaauuu uauuaaugac                                                   20


<210>  32726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32726
auuggaacac agacacucau                                                   20


<210>  32727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32727
uugucauuaa uaaaauucua                                                   20


<210>  32728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32728
aacuuccuug ucauuaauaa                                                   20


<210>  32729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32729
uauaauuuuc accugucaug                                                   20


<210>  32730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32730
ccugucauga gauaguauuu                                                   20


<210>  32731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32731
uagcuuguga acuagccaaa                                                   20


<210>  32732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32732
caagcuaaga aauguuuuua                                                   20


<210>  32733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32733
cacuccuagg uuaaaauaug                                                   20


<210>  32734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32734
aaaugugguc cuaucauauu                                                   20


<210>  32735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32735
uuuuuuuuuu uuuuuuuuuu                                                   20


<210>  32736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32736
cucuuguugc ccaggcugga                                                   20


<210>  32737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32737
agacauucuc cugcacggcc                                                   20


<210>  32738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32738
ccugcacggc cucccuagua                                                   20


<210>  32739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32739
ccauguuggu caggcugguc                                                   20


<210>  32740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32740
agaccagccu gaccaacaug                                                   20


<210>  32741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32741
agcagggugu gguggcucac                                                   20


<210>  32742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32742
uuuuuggcug uuuuuguuuu                                                   20


<210>  32743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32743
aaacuaguuu aaaaaaaaaa                                                   20


<210>  32744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32744
agcagcacag augaaaaaca                                                   20


<210>  32745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32745
ucugugcugc uugaagauau                                                   20


<210>  32746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32746
ugcaagucug ucaucuuugu                                                   20


<210>  32747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32747
uaagaacaaa aguguuucuu                                                   20


<210>  32748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32748
uaggaaguua gacaaagaug                                                   20


<210>  32749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32749
ugugucuucu ucccagauuu                                                   20


<210>  32750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32750
ucccagauuu uaauaugcau                                                   20


<210>  32751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32751
cagauuuuaa uaugcauaua                                                   20


<210>  32752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32752
auagcaguac cuguaauucu                                                   20


<210>  32753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32753
uauuaauugc uauguaauau                                                   20


<210>  32754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32754
aaaauauuac auagcaauua                                                   20


<210>  32755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32755
uuuuaaaaga ggacuuuugg                                                   20


<210>  32756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32756
acagccacaa aaaugugaga                                                   20


<210>  32757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32757
cucuaccuug agaagucccc                                                   20


<210>  32758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32758
caagguagag agaauauguc                                                   20


<210>  32759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32759
uguaaauaag ucaaccacuu                                                   20


<210>  32760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32760
aagguaguuu aucaaguggu                                                   20


<210>  32761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32761
gacaacaagg aggaaaaaua                                                   20


<210>  32762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32762
uccuuguugu cugaauaaga                                                   20


<210>  32763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32763
agcccccaaa uugauccaau                                                   20


<210>  32764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32764
gugagugacu uacaugcaca                                                   20


<210>  32765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32765
caaacuccaa ugugcaugua                                                   20


<210>  32766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32766
ucccaaaugc uugcauuguu                                                   20


<210>  32767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32767
guagcuguga ugagugagcu                                                   20


<210>  32768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32768
ucuaagcgag ucccacuacc                                                   20


<210>  32769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32769
aguucaucua agcgaguccc                                                   20


<210>  32770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32770
ucugagcagc cacuauggag                                                   20


<210>  32771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32771
ccauaguggc ugcucagaug                                                   20


<210>  32772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32772
guuguuuuuc uccauagugg                                                   20


<210>  32773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32773
aaccacagcu cuccuuugug                                                   20


<210>  32774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32774
acucaaaugu caccuucuaa                                                   20


<210>  32775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32775
cccgcuauac acauggcuug                                                   20


<210>  32776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32776
guuaacucug ccuggaccuc                                                   20


<210>  32777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32777
gccuucuguu aacucugccu                                                   20


<210>  32778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32778
auguuugaga accaguaagg                                                   20


<210>  32779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32779
caaacaugga aagcauuucu                                                   20


<210>  32780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32780
gccacuggcc uccuuacugg                                                   20


<210>  32781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32781
ccuuacuuca gccacuggcc                                                   20


<210>  32782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32782
gcccuucacc uuacuucagc                                                   20


<210>  32783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32783
ugccuguaau accaguaguu                                                   20


<210>  32784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32784
ucuaaaugca uauauauaca                                                   20


<210>  32785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32785
aaauccucac cagcaugugg                                                   20


<210>  32786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32786
caccagcaau aagugaccua                                                   20


<210>  32787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32787
agaguggccg uacuauauua                                                   20


<210>  32788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32788
guuuuaugac aaacugccaa                                                   20


<210>  32789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32789
cuaggauuaa ugcccaggau                                                   20


<210>  32790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32790
uuucucuagg auuaaugccc                                                   20


<210>  32791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32791
cauaaaaacc uauacucaag                                                   20


<210>  32792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32792
uagauauuau ggguaaagcu                                                   20


<210>  32793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32793
aguucuuaga uauuaugggu                                                   20


<210>  32794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32794
acaggugaau gguuaaacua                                                   20


<210>  32795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32795
ccuguugaag gacaucugag                                                   20


<210>  32796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32796
uuuuuauuac ugaguaguuu                                                   20


<210>  32797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32797
ccuaaacugu ugcaugcuau                                                   20


<210>  32798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32798
uuagcauaac uucaccuaaa                                                   20


<210>  32799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32799
auguuuuuuu gcaauggcac                                                   20


<210>  32800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32800
ccaucccuaa aacugugcca                                                   20


<210>  32801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32801
cuccucugcc accacuaacc                                                   20


<210>  32802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32802
ccucccucuc uuuucucucc                                                   20


<210>  32803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32803
ccuguguugu ccuuuuauaa                                                   20


<210>  32804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32804
auuacaagua uuccccugug                                                   20


<210>  32805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32805
cacugcaacc ucugccuccu                                                   20


<210>  32806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32806
agugauacuu gugucucagu                                                   20


<210>  32807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32807
gagugaaaca aaccagaggu                                                   20


<210>  32808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32808
cucugaacau gggagacuga                                                   20


<210>  32809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32809
uccaaauaau ccaacacaca                                                   20


<210>  32810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32810
agaccagccg ggccaacaug                                                   20


<210>  32811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32811
ucauguuggc ccggcugguc                                                   20


<210>  32812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32812
cuugccucag ccucccaagu                                                   20


<210>  32813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32813
agcaguucuc uugccucagc                                                   20


<210>  32814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32814
gccuguguga cagaguaaga                                                   20


<210>  32815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32815
ccguguuagc cgggaugguc                                                   20


<210>  32816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32816
gccucccaag uagcugggac                                                   20


<210>  32817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32817
ccugcuucag ccucccaagu                                                   20


<210>  32818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32818
caccauucuc cugcuucagc                                                   20


<210>  32819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32819
cccgagacgg agucuugcuc                                                   20


<210>  32820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32820
auuuauuuau uuuuuuuuuu                                                   20


<210>  32821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32821
ccaggcuaga gugcaauggc                                                   20


<210>  32822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32822
agcaguucuu cugccgcagc                                                   20


<210>  32823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32823
ucugccgcag ccucccgagu                                                   20


<210>  32824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32824
gccgcagccu cccgaguagc                                                   20


<210>  32825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32825
ccaugcuggc caggcugguc                                                   20


<210>  32826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32826
agaccagccu ggccagcaug                                                   20


<210>  32827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32827
aaauuaaaac aaacggccag                                                   20


<210>  32828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32828
ccuucaaaau uaaaacaaac                                                   20


<210>  32829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32829
cuucaccuuc aaaauuaaaa                                                   20


<210>  32830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32830
aucacuuuug guaaauguag                                                   20


<210>  32831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32831
uacccuguuu uuccaguucu                                                   20


<210>  32832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32832
aguucuugcu cagagcaagg                                                   20


<210>  32833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32833
ugcucagagc aaggugguuu                                                   20


<210>  32834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32834
uuuucacuua aucaccauac                                                   20


<210>  32835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32835
cuuaaucacc auacuuacuu                                                   20


<210>  32836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32836
uguagaacaa gucaguuuga                                                   20


<210>  32837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32837
acaugaaaag uaaguauggu                                                   20


<210>  32838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32838
ucaucuuaac uaaauuccau                                                   20


<210>  32839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32839
augggggaag gaauuaguuu                                                   20


<210>  32840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32840
cccauggaau uuaguuaaga                                                   20


<210>  32841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32841
uucccccaug gaauuuaguu                                                   20


<210>  32842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32842
uaaacuucca gguuugcuua                                                   20


<210>  32843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32843
agguuugcuu auuggacaaa                                                   20


<210>  32844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32844
uugguaauac aauuuucuca                                                   20


<210>  32845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32845
cagaaacuua guagucuuuu                                                   20


<210>  32846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32846
gagaaaauug uauuaccaaa                                                   20


<210>  32847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32847
caguuggcac uaucaaaaua                                                   20


<210>  32848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32848
gaugucuuca caguuggcac                                                   20


<210>  32849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32849
cauccaaacc uauggcuuca                                                   20


<210>  32850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32850
ccaggcuguu uaucuccuuu                                                   20


<210>  32851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32851
cagccaagca aaaggagaua                                                   20


<210>  32852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32852
cagcuauuug gggacauaga                                                   20


<210>  32853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32853
auguccccaa auagcuggga                                                   20


<210>  32854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32854
caaaaucguu aacugacuac                                                   20


<210>  32855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32855
guucucaaaa ucguuaacug                                                   20


<210>  32856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32856
ucuaauugaa uuucccaucu                                                   20


<210>  32857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32857
aauugaauuu cccaucucuu                                                   20


<210>  32858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32858
auuagaagaa acacagucua                                                   20


<210>  32859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32859
caucucuugu aaucuaugcc                                                   20


<210>  32860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32860
guacugcuga gaaagaaaga                                                   20


<210>  32861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32861
cagcaguaca gaagaugaug                                                   20


<210>  32862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32862
uucucagcag uacagaagau                                                   20


<210>  32863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32863
uucuuucuca gcaguacaga                                                   20


<210>  32864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32864
aaucaaacua uaccacuggu                                                   20


<210>  32865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32865
aacgugaaau ugauugagua                                                   20


<210>  32866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32866
cguuugaauc auguguuaac                                                   20


<210>  32867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32867
ccaauacuca aucaauuuca                                                   20


<210>  32868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32868
ggcuuuaaau cuccucugua                                                   20


<210>  32869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32869
uaucugugug aucuugggca                                                   20


<210>  32870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32870
auuucuucuc ucuauaaugg                                                   20


<210>  32871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32871
ucucucuaua augggggaag                                                   20


<210>  32872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32872
cucuauaaug ggggaaguga                                                   20


<210>  32873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32873
cccauuauag agagaagaaa                                                   20


<210>  32874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32874
caucuuggcc ucccaaagca                                                   20


<210>  32875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32875
aaauauuuug uagagacggg                                                   20


<210>  32876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32876
gccuaggagu uuaaggcuaa                                                   20


<210>  32877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32877
cccauuuuac uuuauuuuac                                                   20


<210>  32878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32878
uuucccccau uuuacuuuau                                                   20


<210>  32879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32879
gugagcagcg uagcuugaca                                                   20


<210>  32880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32880
ccaauggcug ucaagcuacg                                                   20


<210>  32881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32881
cuguccagau ccccauucug                                                   20


<210>  32882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32882
gcccgcaaca uggaguauaa                                                   20


<210>  32883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32883
uaguagucga gaaacacuca                                                   20


<210>  32884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32884
cgacuacuau gaauaaaccg                                                   20


<210>  32885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32885
gugaguguuu cucgacuacu                                                   20


<210>  32886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32886
uucagugagu guuucucgac                                                   20


<210>  32887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32887
uucauucagu gaguguuucu                                                   20


<210>  32888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32888
acaccucauu cauucauuca                                                   20


<210>  32889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32889
acacauauua auuuccuucu                                                   20


<210>  32890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32890
uucuuuuuuu uauuuuuaga                                                   20


<210>  32891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32891
uuuuuuuauu uuuagaaaga                                                   20


<210>  32892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32892
aaaaauaaaa aaaagaagga                                                   20


<210>  32893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32893
uucuaaaaau aaaaaaaaga                                                   20


<210>  32894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32894
uucuuucuaa aaauaaaaaa                                                   20


<210>  32895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32895
gcuaccaaga aagaccgugu                                                   20


<210>  32896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32896
ugguagcuga aaguucuuuc                                                   20


<210>  32897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32897
cacggucuuu cuugguagcu                                                   20


<210>  32898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32898
cauauuguca gacaaugauu                                                   20


<210>  32899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32899
aagugcaauu accugacaga                                                   20


<210>  32900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32900
cuagacaguu caaagugcaa                                                   20


<210>  32901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32901
uauuuucucu agacaguuca                                                   20


<210>  32902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32902
gucuuaaugg gcuagaauau                                                   20


<210>  32903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32903
agcccauuaa gacugaaaau                                                   20


<210>  32904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32904
uuguguccca gcuauuuuaa                                                   20


<210>  32905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32905
gaaauccauu uaagaugaag                                                   20


<210>  32906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32906
gaauccauuu aaaauagcug                                                   20


<210>  32907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32907
ucuuaaaugg auuucugaau                                                   20


<210>  32908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32908
ucaucuuaaa uggauuucug                                                   20


<210>  32909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32909
cauauuucug gcuauauaca                                                   20


<210>  32910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32910
ggcuauauac aaggauaucc                                                   20


<210>  32911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32911
gugucuggau auccuuguau                                                   20


<210>  32912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32912
uuucaguguc uggauauccu                                                   20


<210>  32913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32913
cuuuuuguaa ucuuuuaugc                                                   20


<210>  32914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32914
auuaccauaa ugguuuuaau                                                   20


<210>  32915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32915
uacuauugca acaaaugcaa                                                   20


<210>  32916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32916
guuugucucu cuuauuugcu                                                   20


<210>  32917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32917
uggcaguuug cuguccuauu                                                   20


<210>  32918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32918
ggauuagugg ggaucguggg                                                   20


<210>  32919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32919
uugcuugauc uuucucacug                                                   20


<210>  32920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32920
cacugggaug aacuagcagc                                                   20


<210>  32921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32921
ucccagugag aaagaucaag                                                   20


<210>  32922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32922
uuuguagcug cuuugcuuuu                                                   20


<210>  32923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32923
gaccguuguu ccuaguagcu                                                   20


<210>  32924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32924
uaguagcugu agaugguaaa                                                   20


<210>  32925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32925
aauggcucag uaggagacau                                                   20


<210>  32926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32926
ccuaugauau cugaauucug                                                   20


<210>  32927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32927
gauaucauag gugaauaugu                                                   20


<210>  32928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32928
guuacccaca ugggcaugcg                                                   20


<210>  32929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32929
cgcaugccca uguggguaac                                                   20


<210>  32930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32930
cuuggaauaa auaauucaug                                                   20


<210>  32931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32931
aagggaaagu aaggcaaggc                                                   20


<210>  32932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32932
uguuauucuc cugguagaag                                                   20


<210>  32933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32933
ccugguagaa gcuagaaaaa                                                   20


<210>  32934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32934
accaggagaa uaacaugaau                                                   20


<210>  32935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32935
agcuucuacc aggagaauaa                                                   20


<210>  32936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32936
gacugacuau aaaggcuuuu                                                   20


<210>  32937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32937
uuuuuuaauu uuuuuuugag                                                   20


<210>  32938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32938
cucuuguugc ccaggcugga                                                   20


<210>  32939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32939
agugauucuc cugccucagc                                                   20


<210>  32940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32940
ccugccucag ccucccaagu                                                   20


<210>  32941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32941
agaucagccu gaccaacauc                                                   20


<210>  32942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32942
uuuguuuuuu caaaaaauuu                                                   20


<210>  32943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32943
aaaaauuucc ucuuggccau                                                   20


<210>  32944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32944
ucuuggccau ugcuuuucac                                                   20


<210>  32945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32945
cuuuuguuuu uuuuuuuuuu                                                   20


<210>  32946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32946
cgccauucuc cugcuucagc                                                   20


<210>  32947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32947
ccugcuucag ccuggcgagu                                                   20


<210>  32948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32948
gccuggcgag uagcugggac                                                   20


<210>  32949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32949
ccguggucuu gaucuccuga                                                   20


<210>  32950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32950
guauauauau ucguaauguu                                                   20


<210>  32951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32951
uaauguugua cagccaucac                                                   20


<210>  32952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32952
uaaguuuuuc uucugucaaa                                                   20


<210>  32953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32953
ucugucaaaa cugaacaucu                                                   20


<210>  32954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32954
gucaaaacug aacaucuguc                                                   20


<210>  32955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32955
guuuugacag aagaaaaacu                                                   20


<210>  32956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32956
uuaaacuccc uaucauccau                                                   20


<210>  32957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32957
uuccuguagu cccuuucuac                                                   20


<210>  32958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32958
uguagucccu uucuacuuuc                                                   20


<210>  32959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32959
acuuucuguc uguaugagug                                                   20


<210>  32960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32960
gucuguauga guguaacugc                                                   20


<210>  32961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32961
uacaggauuu guguuuuuuu                                                   20


<210>  32962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32962
aagugauuuc acaaaaccgu                                                   20


<210>  32963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32963
caaaaccguu ucauuuuagg                                                   20


<210>  32964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32964
uuuuagguua acucauuucu                                                   20


<210>  32965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32965
guuguuugug aaauacugug                                                   20


<210>  32966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32966
caaacaacag aaaugaguua                                                   20


<210>  32967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32967
guucuguuuc ugucuaauuu                                                   20


<210>  32968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32968
guuucugucu aauuugugga                                                   20


<210>  32969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32969
gucuaauuug uggaaauguu                                                   20


<210>  32970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32970
acaaauuaga cagaaacaga                                                   20


<210>  32971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32971
cacaacauuu ccacaaauua                                                   20


<210>  32972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32972
ucccacaaca uuuccacaaa                                                   20


<210>  32973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32973
uuuucuuccc acaacauuuc                                                   20


<210>  32974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32974
ggacauaugc ucauuuguua                                                   20


<210>  32975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32975
aaguuagcau gcuauuguag                                                   20


<210>  32976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32976
acaauagcau gcuaacuuag                                                   20


<210>  32977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32977
uacuuuuauc auagcguugu                                                   20


<210>  32978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32978
aaccuuuuuu uuuccuacuu                                                   20


<210>  32979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32979
aucucugcua ccuguguaag                                                   20


<210>  32980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32980
aaaaugagcc aguaaggcuc                                                   20


<210>  32981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32981
ugugggauca gaugguacau                                                   20


<210>  32982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32982
cauguaccau cugaucccac                                                   20


<210>  32983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32983
caguguuuca cauguaccau                                                   20


<210>  32984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32984
uuagccaccu gagcgggaag                                                   20


<210>  32985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32985
cgcucaggug gcuaaugaac                                                   20


<210>  32986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32986
cgcuauucuc cugccccagc                                                   20


<210>  32987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32987
ccugccccag ccucccaagu                                                   20


<210>  32988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32988
ccguguuagc caggaugguc                                                   20


<210>  32989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32989
caaaaaaagu aaagauggcc                                                   20


<210>  32990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32990
ucugaucucc accauccagg                                                   20


<210>  32991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32991
cugagaccug gaugguggag                                                   20


<210>  32992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32992
cucugaaagc uuauugaccc                                                   20


<210>  32993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32993
gagagaaauu auguucucug                                                   20


<210>  32994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32994
ugggucaaua agcuuucaga                                                   20


<210>  32995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32995
aucugagugc gucaggcuuu                                                   20


<210>  32996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32996
ugucauuuug ucuuuugaua                                                   20


<210>  32997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32997
aauggaauuc auggaauguu                                                   20


<210>  32998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32998
auuugaaaau uaucaaaaga                                                   20


<210>  32999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  32999
uggaauguug gcuuauauuc                                                   20


<210>  33000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33000
augaauucca uuugaaaauu                                                   20


<210>  33001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33001
uauauuagua aaguauguug                                                   20


<210>  33002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33002
auaugccaua uuaaaucaaa                                                   20


<210>  33003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33003
cauuagucug ucucuuguuu                                                   20


<210>  33004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33004
uuaugcuugu ucuacagaag                                                   20


<210>  33005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33005
acagaagagc auguuaaaag                                                   20


<210>  33006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33006
guagaacaag cauaaugaac                                                   20


<210>  33007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33007
ugguuucaua ggauacacuc                                                   20


<210>  33008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33008
uaggauacac ucuauacuuu                                                   20


<210>  33009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33009
gaguauauag cugaagguga                                                   20


<210>  33010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33010
gcuauauacu cugaaauccc                                                   20


<210>  33011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33011
auaaaacaua uuuacauaaa                                                   20


<210>  33012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33012
uguuaacucu ccuaaaauau                                                   20


<210>  33013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33013
aaaaguuuaa uuauauuuua                                                   20


<210>  33014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33014
gacguuuuca auguaggaag                                                   20


<210>  33015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33015
auguaggaag ucauuuaaaa                                                   20


<210>  33016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33016
uacauugaaa acgucagaag                                                   20


<210>  33017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33017
uguauauugu gaaaauguag                                                   20


<210>  33018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33018
caauauacau gaaguuuuaa                                                   20


<210>  33019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33019
uaaguaugga ugagcaucaa                                                   20


<210>  33020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33020
agaugauuuu gaugcucauc                                                   20


<210>  33021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33021
uuacuguauu uuuaacaaau                                                   20


<210>  33022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33022
caaacauacu ucugcauucu                                                   20


<210>  33023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33023
gcauucuguu ugaguaggua                                                   20


<210>  33024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33024
guuugaguag guagggacua                                                   20


<210>  33025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33025
caaguauccu cuugggaaua                                                   20


<210>  33026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33026
caagaggaua cuugugaaaa                                                   20


<210>  33027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33027
uggguauucc caagaggaua                                                   20


<210>  33028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33028
agcugauuua ugcuaauaua                                                   20


<210>  33029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33029
caguagcacc aauauaucga                                                   20


<210>  33030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33030
auauauuggu gcuacuguga                                                   20


<210>  33031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33031
uuagaguucg auauauuggu                                                   20


<210>  33032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33032
guuaauguuu cugaaagaua                                                   20


<210>  33033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33033
gaaagauaua ggugaccacu                                                   20


<210>  33034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33034
gaaacauuaa cagaaguuuu                                                   20


<210>  33035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33035
agauaggaag auuuuauauu                                                   20


<210>  33036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33036
uaucuagaaa guggucaccu                                                   20


<210>  33037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33037
acuuaguaau auaaaaucuu                                                   20


<210>  33038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33038
cuaaauuaac acagaaauuu                                                   20


<210>  33039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33039
guguuaauuu agagaaaauu                                                   20


<210>  33040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33040
aguagaggua uuuuugaacu                                                   20


<210>  33041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33041
aaaauaccuc uacuagaauu                                                   20


<210>  33042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33042
cugcaagaau aaauacauaa                                                   20


<210>  33043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33043
ugcagugaac aaguucaaaa                                                   20


<210>  33044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33044
uugcaauuau guauuuauuc                                                   20


<210>  33045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33045
ccgcacuggu ccagcugguc                                                   20


<210>  33046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33046
ccugccucag ccucccaagu                                                   20


<210>  33047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33047
agcaauucuc cugccucagc                                                   20


<210>  33048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33048
agccugggcg acaagagcaa                                                   20


<210>  33049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33049
gucucaagaa aaaagagaaa                                                   20


<210>  33050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33050
ugagacagaa uuuugcucuu                                                   20


<210>  33051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33051
cuuuuuucuu gagacagaau                                                   20


<210>  33052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33052
uuuuucucuu uuuucuugag                                                   20


<210>  33053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33053
uuuucuuuuu ucucuuuuuu                                                   20


<210>  33054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33054
auaccuguuu uaacauccaa                                                   20


<210>  33055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33055
guucuauacc uguuuuaaca                                                   20


<210>  33056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33056
uucuguucua uaccuguuuu                                                   20


<210>  33057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33057
uacagauaca cacauacacu                                                   20


<210>  33058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33058
cuaauacaua uauguuacac                                                   20


<210>  33059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33059
cucauuuccc uaauacauau                                                   20


<210>  33060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33060
cugacuuugg gagaacauua                                                   20


<210>  33061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33061
cccaaaguca gagaaaugua                                                   20


<210>  33062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33062
gauuaauuac cuaaauguga                                                   20


<210>  33063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33063
cauuuaggua auuaaucuga                                                   20


<210>  33064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33064
uuuuuucaca uuuagguaau                                                   20


<210>  33065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33065
uuaaaaaaug uaaucuuagu                                                   20


<210>  33066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33066
ucaaacuaag auuacauuuu                                                   20


<210>  33067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33067
uuuauaaugu uaaccuuccu                                                   20


<210>  33068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33068
acucaaaaca guuuuuuccu                                                   20


<210>  33069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33069
auaugucaaa auccaccuuc                                                   20


<210>  33070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33070
acaaaauuga aaguaaauug                                                   20


<210>  33071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33071
auuuuguuga agguggauuu                                                   20


<210>  33072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33072
auuuacuuuc aauuuuguug                                                   20


<210>  33073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33073
ccaaguucaa uuuacuuuca                                                   20


<210>  33074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33074
uaacgauauu uauaacugcu                                                   20


<210>  33075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33075
ccgacuccca gccuccagaa                                                   20


<210>  33076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33076
ggaggcuggg agucggagaa                                                   20


<210>  33077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33077
auaacaaaau accacauaca                                                   20


<210>  33078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33078
gucuacugau uacuaguguc                                                   20


<210>  33079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33079
guuucagucu acugauuacu                                                   20


<210>  33080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33080
uauuuuuguu ucaguuucag                                                   20


<210>  33081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33081
uaauguuugc caauuugaca                                                   20


<210>  33082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33082
gauuuuuguc agaggugaua                                                   20


<210>  33083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33083
aagaaggcaa uuugggaaaa                                                   20


<210>  33084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33084
uagaagguug uaucaccucu                                                   20


<210>  33085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33085
caaauugccu ucuuagaagg                                                   20


<210>  33086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33086
uagggguaag cacccuagag                                                   20


<210>  33087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33087
ucccauuaga aaauuaaaaa                                                   20


<210>  33088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33088
aaugggauga agggcacugc                                                   20


<210>  33089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33089
auccccuuuu agugguaggc                                                   20


<210>  33090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33090
cggguucaug ugauucuccu                                                   20


<210>  33091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33091
ugugauucuc cugccucagc                                                   20


<210>  33092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33092
ccugccucag ccuccugagu                                                   20


<210>  33093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33093
cuguguuggc cagacugguc                                                   20


<210>  33094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33094
agaccagucu ggccaacaca                                                   20


<210>  33095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33095
cuuguauaaa uguaucuggc                                                   20


<210>  33096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33096
uagauauuua uauuuuguuu                                                   20


<210>  33097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33097
ggcugcagug ggcuaugauu                                                   20


<210>  33098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33098
gccucagccu uuugaguacc                                                   20


<210>  33099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33099
agaccagccu gggcaauaca                                                   20


<210>  33100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33100
ugggcccaag ugauccuccc                                                   20


<210>  33101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33101
gaccaauaga uauuuauauu                                                   20


<210>  33102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33102
agucacaaau auaaauaucu                                                   20


<210>  33103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33103
guuaaaaaau aaugaaagau                                                   20


<210>  33104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33104
uuauuuuuua acugaauuuu                                                   20


<210>  33105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33105
ggcuaagaua gaauaacaag                                                   20


<210>  33106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33106
aucuuagcca gaagcaaaaa                                                   20


<210>  33107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33107
ugccuugaaa uaguugaaaa                                                   20


<210>  33108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33108
aggcaagaag auaaaugcug                                                   20


<210>  33109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33109
acuauuucaa ggcaagaaga                                                   20


<210>  33110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33110
guuuucaacu auuucaaggc                                                   20


<210>  33111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33111
uccguuuuca acuauuucaa                                                   20


<210>  33112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33112
aguuauuggg caucaggcaa                                                   20


<210>  33113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33113
uugccugaug cccaauaacu                                                   20


<210>  33114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33114
ucuuugccug augcccaaua                                                   20


<210>  33115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33115
ugggauaacu auucuucuuu                                                   20


<210>  33116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33116
uuuuccuggg auaacuauuc                                                   20


<210>  33117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33117
uuacauuacu gccuggucau                                                   20


<210>  33118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33118
ucuugccaug accaggcagu                                                   20


<210>  33119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33119
auaugggcuc ucaccaccuu                                                   20


<210>  33120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33120
uccauauggg cucucaccac                                                   20


<210>  33121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33121
cugguauucu uccauauggg                                                   20


<210>  33122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33122
gcacaagcaa gugcucguca                                                   20


<210>  33123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33123
gguggcucua ccuccagccc                                                   20


<210>  33124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33124
aauccuuuca gguggcucua                                                   20


<210>  33125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33125
uucuaauccu uucagguggc                                                   20


<210>  33126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33126
gcaacuguuc cuucuaaucc                                                   20


<210>  33127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33127
uggcccugug ugacuuucag                                                   20


<210>  33128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33128
uccuggcccu gugugacuuu                                                   20


<210>  33129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33129
aaucacacca guuggagugg                                                   20


<210>  33130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33130
acuccaacug gugugauuag                                                   20


<210>  33131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33131
gaguacccua ccugcucuau                                                   20


<210>  33132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33132
uuacucugac ccuaccuaau                                                   20


<210>  33133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33133
caacaaaaau aauauauuuc                                                   20


<210>  33134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33134
guguuuguaa cacguagaag                                                   20


<210>  33135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33135
acguguuaca aacacugaaa                                                   20


<210>  33136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33136
cuucuacgug uuacaaacac                                                   20


<210>  33137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33137
agccuuuaug cuauugucau                                                   20


<210>  33138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33138
gcucuuccag ccuuuaugcu                                                   20


<210>  33139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33139
gcccagcgca aauacauguc                                                   20


<210>  33140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33140
ccaaaagaua ucaaguccua                                                   20


<210>  33141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33141
auauaaagua auauuuacag                                                   20


<210>  33142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33142
ggaucuugag augagggggc                                                   20


<210>  33143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33143
cucugugugu aaaaucuccc                                                   20


<210>  33144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33144
cagggccuuc ucucugugug                                                   20


<210>  33145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33145
aucuucacag ggccuucucu                                                   20


<210>  33146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33146
guuccaucuu cacagggccu                                                   20


<210>  33147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33147
aaucuuucug uuccaucuuc                                                   20


<210>  33148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33148
aggccagcac cuucaaaucu                                                   20


<210>  33149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33149
ucacuccaau uuucaaggcc                                                   20


<210>  33150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33150
uuggcuuaua gcuucaucac                                                   20


<210>  33151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33151
agcuuuggug gcugcugcau                                                   20


<210>  33152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33152
cauuuagagc cuacuccaga                                                   20


<210>  33153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33153
cucuggagua ggcucuaaau                                                   20


<210>  33154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33154
uuuuuuuuuu uuuuuuuuaa                                                   20


<210>  33155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33155
uggguguuuc uuggagaggg                                                   20


<210>  33156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33156
uggagagggg gauuuggcag                                                   20


<210>  33157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33157
cuccacuauu guccuaugac                                                   20


<210>  33158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33158
uaggcagagg gcccugccac                                                   20


<210>  33159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33159
gcaguguuug ugucccuggg                                                   20


<210>  33160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33160
agcaucuguu uaacaaagca                                                   20


<210>  33161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33161
gagagcacgg gguugggggu                                                   20


<210>  33162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33162
gccuugggau gcuguuaauc                                                   20


<210>  33163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33163
ucugccuugg gaugcuguua                                                   20


<210>  33164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33164
uaguacagaa caaaauggag                                                   20


<210>  33165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33165
guacuaagaa aaauucuucu                                                   20


<210>  33166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33166
uucuacgcag acacaguaac                                                   20


<210>  33167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33167
acgcagacac aguaacaauc                                                   20


<210>  33168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33168
uuucccacau uuccuccuuu                                                   20


<210>  33169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33169
cacauuuccu ccuuuucuau                                                   20


<210>  33170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33170
uccuuuucua uucgacaaaa                                                   20


<210>  33171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33171
auucgacaaa acugccaccg                                                   20


<210>  33172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33172
acaaaacugc caccgucauc                                                   20


<210>  33173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33173
caaugagcua uuggguacac                                                   20


<210>  33174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33174
cagauggggc ggccgggcag                                                   20


<210>  33175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33175
cggacggggc ggcugcuggg                                                   20


<210>  33176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33176
cagacggggc ggcuggucag                                                   20


<210>  33177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33177
uaaguuccca gacggaguca                                                   20


<210>  33178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33178
cagacggagu cacggccggg                                                   20


<210>  33179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33179
caucucagac ggggcggcgg                                                   20


<210>  33180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33180
cagacgaugg gcggccgggc                                                   20


<210>  33181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33181
uagaugggau gacagccggg                                                   20


<210>  33182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33182
cggcugucau cccaucuagg                                                   20


<210>  33183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33183
cagacugggc agccaggcag                                                   20


<210>  33184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33184
gccuggccgc ccaucgucug                                                   20


<210>  33185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33185
uagacggggu ggcggcuggg                                                   20


<210>  33186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33186
ccucccagcc gccugccuug                                                   20


<210>  33187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33187
ccguguuggc cgggcugguc                                                   20


<210>  33188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33188
uguuuuuugg uggagacggg                                                   20


<210>  33189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33189
ccugccucag ccugccaagu                                                   20


<210>  33190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33190
cucgcccucg cccucgcccu                                                   20


<210>  33191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33191
uuaauuucag uuuagugaua                                                   20


<210>  33192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33192
guuuagugau acuaauuuug                                                   20


<210>  33193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33193
caguuuuaga ggccagaguc                                                   20


<210>  33194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33194
uucacaguuu uagaggccag                                                   20


<210>  33195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33195
uuuaagccac auaguuugug                                                   20


<210>  33196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33196
ugcagcugcu guaacaaauu                                                   20


<210>  33197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33197
caugcagcau aaauuaguuu                                                   20


<210>  33198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33198
ucacaaucua ccuuauuaca                                                   20


<210>  33199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33199
uuguugugcu uuuaguuguu                                                   20


<210>  33200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33200
uuagcuauaa uuccuuguug                                                   20


<210>  33201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33201
aaucuccuuu uuugguucau                                                   20


<210>  33202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33202
ccauuuuuau uauucuaauc                                                   20


<210>  33203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33203
uugggauuca ccauuuuuau                                                   20


<210>  33204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33204
ggcuucuuug ggauucacca                                                   20


<210>  33205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33205
ccuauuucug gcuucuuugg                                                   20


<210>  33206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33206
uuuauuugcc ucuuccccua                                                   20


<210>  33207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33207
uuccuuuauu ugccucuucc                                                   20


<210>  33208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33208
accuaacuau gucaaaaagg                                                   20


<210>  33209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33209
gauugaaugg aaaaguaaga                                                   20


<210>  33210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33210
aucugaaaaa ucgcugccuu                                                   20


<210>  33211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33211
auucaaucug aaaaaucgcu                                                   20


<210>  33212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33212
ugcaggcagc agcauauacc                                                   20


<210>  33213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33213
aaauauaaag gcaaaaauaa                                                   20


<210>  33214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33214
guuaccugua gguuauuuuu                                                   20


<210>  33215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33215
guucuguuac cuguagguua                                                   20


<210>  33216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33216
uuccguucug uuaccuguag                                                   20


<210>  33217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33217
cugugcuuac aagaauuaga                                                   20


<210>  33218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33218
uguaagcaca gugaacuucu                                                   20


<210>  33219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33219
guuaauauca gacaaagugg                                                   20


<210>  33220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33220
aagcaaaggc ucuugcccag                                                   20


<210>  33221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33221
uaaugaugaa ggggauucgu                                                   20


<210>  33222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33222
ucauuaugaa augaccaucu                                                   20


<210>  33223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33223
uucaucagcc uggcauagca                                                   20


<210>  33224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33224
ucagccuggc auagcaagcu                                                   20


<210>  33225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33225
gcuugcuaug ccaggcugau                                                   20


<210>  33226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33226
uguauuuuag cucuguaguc                                                   20


<210>  33227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33227
gucaggcuuu gcuucaugua                                                   20


<210>  33228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33228
acuuguaguu cugucaggcu                                                   20


<210>  33229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33229
guagccgcuc ucaaugauuu                                                   20


<210>  33230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33230
acaaaucauu gagagcggcu                                                   20


<210>  33231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33231
agauccagau auuauggcua                                                   20


<210>  33232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33232
gcuggugcug gguggagugu                                                   20


<210>  33233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33233
gugagcacuu gagagagugu                                                   20


<210>  33234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33234
aauuauucag aguauguuuu                                                   20


<210>  33235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33235
gaguauguuu ucugaccuca                                                   20


<210>  33236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33236
gaccucagua ucauuaaguu                                                   20


<210>  33237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33237
aacuuaauga uacugagguc                                                   20


<210>  33238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33238
uauaauauau uccaacuuaa                                                   20


<210>  33239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33239
agguuaucuu ccuauaauau                                                   20


<210>  33240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33240
acauaucuga ggcuuuucca                                                   20


<210>  33241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33241
acauggccca ugggucagaa                                                   20


<210>  33242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33242
gacccauggg ccauguggaa                                                   20


<210>  33243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33243
cuucugaccc augggccaug                                                   20


<210>  33244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33244
cuuuugacuu cacuucugac                                                   20


<210>  33245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33245
aauuucccuu uugacuucac                                                   20


<210>  33246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33246
aaacuugugg ggugcuguua                                                   20


<210>  33247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33247
auuuacuaug cuguaacagc                                                   20


<210>  33248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33248
agcauuaaau gccuguuuua                                                   20


<210>  33249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33249
uaaaacaggc auuuaaugcu                                                   20


<210>  33250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33250
uuccuaaaac aggcauuuaa                                                   20


<210>  33251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33251
aaucaaugac cucagcuucu                                                   20


<210>  33252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33252
accuuuggaa acuugaaaau                                                   20


<210>  33253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33253
aaagguagaa gcugagguca                                                   20


<210>  33254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33254
aguuuccaaa gguagaagcu                                                   20


<210>  33255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33255
auuugcuugu cauuuucaag                                                   20


<210>  33256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33256
gguaacucug gauuccauuu                                                   20


<210>  33257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33257
gccacuuugg gaggccgagg                                                   20


<210>  33258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33258
acugccaguc ucaaacaauc                                                   20


<210>  33259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33259
cugcagccuc aaccucccag                                                   20


<210>  33260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33260
auccugggca acagaaugag                                                   20


<210>  33261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33261
guugcccagg auggaacaca                                                   20


<210>  33262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33262
aguaacuguu uuuguuuuug                                                   20


<210>  33263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33263
ucuaguaacu guuuuuguuu                                                   20


<210>  33264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33264
gcuccuaucu uuaugauguc                                                   20


<210>  33265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33265
auuuuacuga cuucugcucc                                                   20


<210>  33266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33266
uauguauuuu uguuuucuau                                                   20


<210>  33267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33267
ucaagaacau caauaaauug                                                   20


<210>  33268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33268
ugaugaacca gcuuuugguu                                                   20


<210>  33269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33269
uaucagcuuu accaauuuau                                                   20


<210>  33270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33270
cuguuuuucc uaucagcuuu                                                   20


<210>  33271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33271
ugauauugcu aauuugugac                                                   20


<210>  33272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33272
cgccuguaau cccagcaccu                                                   20


<210>  33273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33273
ccauguuggc caggcugguc                                                   20


<210>  33274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33274
ccugccucag ccucccaagu                                                   20


<210>  33275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33275
agcaauucuc cugccucagc                                                   20


<210>  33276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33276
uaauauuacc auauaguccu                                                   20


<210>  33277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33277
ucuauaaguu gucaaauuua                                                   20


<210>  33278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33278
uugaaagaca cagaaacuau                                                   20


<210>  33279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33279
aggaacucau ccauuucauc                                                   20


<210>  33280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33280
gugucuuuca aggaacucau                                                   20


<210>  33281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33281
ugagagagcu uuaauaguuu                                                   20


<210>  33282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33282
auaaaauaga uauagggcua                                                   20


<210>  33283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33283
aguaacuaaa uauugauuuu                                                   20


<210>  33284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33284
aaccacacuu aaaaguuuuc                                                   20


<210>  33285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33285
uauaccauuu ccaaccacac                                                   20


<210>  33286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33286
acugaauuuu augaagucua                                                   20


<210>  33287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33287
guugaaaaag uucguauacc                                                   20


<210>  33288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33288
uaaaauucag uugaaaaagu                                                   20


<210>  33289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33289
gaugaaaauu uagugucuga                                                   20


<210>  33290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33290
ucagaaaacc uuuaccugug                                                   20


<210>  33291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33291
gacacuaaau uuucaucaga                                                   20


<210>  33292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33292
ucacauuaau uacauguuga                                                   20


<210>  33293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33293
cauuaauuac auguugaaau                                                   20


<210>  33294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33294
acauguaauu aaugugaaga                                                   20


<210>  33295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33295
uaauauuuaa uuuaacccaa                                                   20


<210>  33296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33296
uuuuacuuuu gaugcgucag                                                   20


<210>  33297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33297
uagcugacgc aucaaaagua                                                   20


<210>  33298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33298
guuucuguug acaguacugc                                                   20


<210>  33299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33299
guugacagua cugcuuugga                                                   20


<210>  33300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33300
aacacugugc uccaaagcag                                                   20


<210>  33301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33301
aagaccuuuc cucaguucgu                                                   20


<210>  33302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33302
ucaguucguu auucauggcu                                                   20


<210>  33303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33303
uuauucaugg cugucuguau                                                   20


<210>  33304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33304
uggcugucug uauuccacau                                                   20


<210>  33305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33305
acauagauaa ggucugaaau                                                   20


<210>  33306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33306
gaccuuaucu auguggaaua                                                   20


<210>  33307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33307
aaccauuguu ugcaauuuuu                                                   20


<210>  33308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33308
cuuuaucucu agguaaaaau                                                   20


<210>  33309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33309
gaguaguuag auugggauca                                                   20


<210>  33310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33310
ugaucccaau cuaacuacuc                                                   20


<210>  33311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33311
aaaauagcac aucccccgua                                                   20


<210>  33312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33312
ugggauuacu ucaagaacau                                                   20


<210>  33313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33313
agaacauccu uguguuacug                                                   20


<210>  33314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33314
ugaaguaauc ccaagaauag                                                   20


<210>  33315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33315
gaaugcugug aagucaguuu                                                   20


<210>  33316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33316
gaagcaucca aaccaguaac                                                   20


<210>  33317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33317
cagcauucag aagcauccaa                                                   20


<210>  33318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33318
uguacauggc ucaucaguuu                                                   20


<210>  33319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33319
uucaauuaaa cauuuuaaaa                                                   20


<210>  33320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33320
auuaaacauu uuaaaauagu                                                   20


<210>  33321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33321
cccuaagaug ccagaugauc                                                   20


<210>  33322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33322
guaugggcca aaguauaacc                                                   20


<210>  33323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33323
gcagucuauc ucuccugccc                                                   20


<210>  33324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33324
agguuccaag aauauuguag                                                   20


<210>  33325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33325
aagaauauug uagguuaaga                                                   20


<210>  33326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33326
uggaaccuug aaaaucaguu                                                   20


<210>  33327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33327
accaaaaguu uacuuuuacu                                                   20


<210>  33328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33328
auccuagaca acccacugcu                                                   20


<210>  33329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33329
gauacuucaa uccuagacaa                                                   20


<210>  33330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33330
uuuaaaaacu ucagauacuu                                                   20


<210>  33331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33331
uuuuaaauuu ucguuuaaaa                                                   20


<210>  33332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33332
cauuuuucuu uuuaaauuuu                                                   20


<210>  33333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33333
uuuuuaaaaa auaaacuuua                                                   20


<210>  33334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33334
aaauaaaguu uauuuuuuaa                                                   20


<210>  33335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33335
auaaaucuaa aacuauuuca                                                   20


<210>  33336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33336
uacccuaucu aauuuuuuuc                                                   20


<210>  33337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33337
uauacccuac auccaguuac                                                   20


<210>  33338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33338
uguuuaauga aucaauauug                                                   20


<210>  33339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33339
uuaaacauga aaaugucuca                                                   20


<210>  33340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33340
gauuuucuua auuucuaugu                                                   20


<210>  33341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33341
uaauuucuau guaauguccu                                                   20


<210>  33342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33342
auguaauguc cuuuuucugu                                                   20


<210>  33343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33343
guuccagaau uccaugcagg                                                   20


<210>  33344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33344
agaauuccau gcaggacacc                                                   20


<210>  33345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33345
ggaacagaaa aaggacauua                                                   20


<210>  33346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33346
augcaggaca ccggauaccu                                                   20


<210>  33347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33347
uugucauguc accuuaggcu                                                   20


<210>  33348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33348
cuucuuuuuu ugcuuagaaa                                                   20


<210>  33349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33349
uuuuuugcuu agaaauucuc                                                   20


<210>  33350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33350
aagcaaaaaa agaagagaaa                                                   20


<210>  33351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33351
ccagaauuuc agaaacuucu                                                   20


<210>  33352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33352
ggagaauuuc uaagcaaaaa                                                   20


<210>  33353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33353
gaaacuucug ggcaucgcua                                                   20


<210>  33354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33354
gaaauucugg agaauuucua                                                   20


<210>  33355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33355
gggcaucgcu auggaacuuu                                                   20


<210>  33356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33356
auagcgaugc ccagaaguuu                                                   20


<210>  33357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33357
gcugugcagu gaugacgcag                                                   20


<210>  33358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33358
ucagccacca uccugacauc                                                   20


<210>  33359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33359
uacuuugaua acuuuguuga                                                   20


<210>  33360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33360
ccucagagcu aucauuguug                                                   20


<210>  33361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33361
cucagccuac aacaaugaua                                                   20


<210>  33362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33362
ucucucagcc uacaacaaug                                                   20


<210>  33363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33363
ucuguuuuga gucccugagg                                                   20


<210>  33364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33364
guuuugaguc ccugaggaug                                                   20


<210>  33365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33365
uuucugaugu augguuugga                                                   20


<210>  33366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33366
gauguauggu uuggaggugc                                                   20


<210>  33367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33367
aaaccauaca auagagcacc                                                   20


<210>  33368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33368
aaaccauaca auagagcacc                                                   20


<210>  33369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33369
gaccgggcag guguggcaag                                                   20


<210>  33370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33370
uugaccuagg caccgugcag                                                   20


<210>  33371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33371
cuucauugac cuaggcaccg                                                   20


<210>  33372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33372
caggagcauc caguggcuac                                                   20


<210>  33373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33373
cuggugccug uagugacauu                                                   20


<210>  33374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33374
augagucuca guuuucuuaa                                                   20


<210>  33375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33375
uaaccauaaa augggaucaa                                                   20


<210>  33376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33376
uaccacuuug aggauccagu                                                   20


<210>  33377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33377
uauuaauaau gacauccuua                                                   20


<210>  33378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33378
cuuuuuccau cacaugguuu                                                   20


<210>  33379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33379
aucacauggu uuccauggua                                                   20


<210>  33380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33380
augguauccu uuugcccagg                                                   20


<210>  33381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33381
cugggcaaaa ggauaccaug                                                   20


<210>  33382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33382
guggucagga cgcuggcuuc                                                   20


<210>  33383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33383
cuggagccau gggauucuag                                                   20


<210>  33384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33384
agcucccugu cuugucccua                                                   20


<210>  33385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33385
cucuccgcuu gcaauuccug                                                   20


<210>  33386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33386
ugcuuugcuc gcaucucacu                                                   20


<210>  33387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33387
ccuuguucuc cgugccugcu                                                   20


<210>  33388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33388
ccgugccugc ugaucauugg                                                   20


<210>  33389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33389
aguuaagcuu gcuucuccac                                                   20


<210>  33390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33390
ccacaggccu aaauauccuu                                                   20


<210>  33391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33391
uuuauucuca cuggcaggac                                                   20


<210>  33392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33392
cacuggcagg accagggcgg                                                   20


<210>  33393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33393
agaccagccu gggcaaccug                                                   20


<210>  33394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33394
caaagugcug ggaucacagg                                                   20


<210>  33395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33395
guucuugaua uuugauccuc                                                   20


<210>  33396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33396
ugauauuuga uccucagagu                                                   20


<210>  33397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33397
gacucugagg aucaaauauc                                                   20


<210>  33398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33398
uggcaaaugg gacguuaaga                                                   20


<210>  33399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33399
cucugcccuc uuaacguccc                                                   20


<210>  33400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33400
uauucucucu gcccucuuaa                                                   20


<210>  33401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33401
guucauauuc ucucugcccu                                                   20


<210>  33402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33402
aauauugguc auuuaaugug                                                   20


<210>  33403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33403
uuuuuaaacc uccuucauuu                                                   20


<210>  33404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33404
uuuuuuuucc aggaauugcu                                                   20


<210>  33405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33405
aggaauugcu ggacacagug                                                   20


<210>  33406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33406
uggaaaaaaa augaaggagg                                                   20


<210>  33407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33407
uggcugucuc cuugcuucuu                                                   20


<210>  33408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33408
uucccauguc cucuucuuug                                                   20


<210>  33409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33409
cauguccucu ucuuuguuuc                                                   20


<210>  33410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33410
uuguuuccag ccauuucucc                                                   20


<210>  33411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33411
agccauuucu cccuuaugcu                                                   20


<210>  33412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33412
cccuuaugcu uaaguuuggu                                                   20


<210>  33413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33413
ugcuuccuca gaugcuguag                                                   20


<210>  33414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33414
ucagaugcug uaguugucag                                                   20


<210>  33415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33415
gguccuagac uuugucuucu                                                   20


<210>  33416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33416
caugaguaug gcugugugug                                                   20


<210>  33417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33417
ccauacacac acagccauac                                                   20


<210>  33418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33418
acuuagccca agaaaauggg                                                   20


<210>  33419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33419
ugggcuaagu agaaccuagu                                                   20


<210>  33420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33420
guagagaaau gcacugggua                                                   20


<210>  33421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33421
cuacagaaac cacaugcaaa                                                   20


<210>  33422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33422
ccgccugaga cuaaccuacc                                                   20


<210>  33423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33423
ugcuggacac acgugcuuca                                                   20


<210>  33424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33424
uauguggcau aaagucuccg                                                   20


<210>  33425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33425
gugaggugcu ggcaaaucac                                                   20


<210>  33426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33426
gccucuugac ggugguggug                                                   20


<210>  33427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33427
ugccucccua gacaaaaauc                                                   20


<210>  33428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33428
uggagucagc agccaguagg                                                   20


<210>  33429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33429
ccuacuggcu gcugacucca                                                   20


<210>  33430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33430
uaaucaucac cgccucuugu                                                   20


<210>  33431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33431
uggcaccccu ugagacaaga                                                   20


<210>  33432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33432
gccuccacag cuuccuggca                                                   20


<210>  33433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33433
cuaccaaaca agguacaacc                                                   20


<210>  33434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33434
agagccccua auucucuacc                                                   20


<210>  33435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33435
uaaaugauac acuccccuga                                                   20


<210>  33436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33436
gcagacacac agguggcugc                                                   20


<210>  33437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33437
cucuugcccc ugcuuccgca                                                   20


<210>  33438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33438
cugcucuuag gaggggcuga                                                   20


<210>  33439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33439
cuuguuauac aauaagcuug                                                   20


<210>  33440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33440
aguuuuauuu aagaaguaau                                                   20


<210>  33441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33441
uaaauaaaac uagaagccuu                                                   20


<210>  33442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33442
acauuacuuc uuaaauaaaa                                                   20


<210>  33443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33443
cuuugcucau uuaaggacuu                                                   20


<210>  33444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33444
guacaaacug caacaacagg                                                   20


<210>  33445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33445
gagauguuuu uacuccucag                                                   20


<210>  33446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33446
gaggaguaaa aacaucucag                                                   20


<210>  33447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33447
cagaauguga ucugguuuug                                                   20


<210>  33448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33448
gggaaauucu gaggaguaaa                                                   20


<210>  33449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33449
agcuugcuga cccaauaggu                                                   20


<210>  33450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33450
uaaaacuugu ggguuaaccu                                                   20


<210>  33451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33451
ucccucuugg gugggcaagc                                                   20


<210>  33452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33452
aaaugcuugc ccacccaaga                                                   20


<210>  33453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33453
cuuccaaaug cuugcccacc                                                   20


<210>  33454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33454
cugucccauc cccuagcuug                                                   20


<210>  33455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33455
caagcuaggg gaugggacag                                                   20


<210>  33456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33456
cuaaugugga cuuugugccg                                                   20


<210>  33457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33457
agcuaguaac gaugcuaacg                                                   20


<210>  33458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33458
gguuuagccu cacaagugag                                                   20


<210>  33459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33459
ucacagcaca ucucucaacc                                                   20


<210>  33460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33460
gcaggugugg ccccuccuca                                                   20


<210>  33461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33461
caaggcggag uccugcaucc                                                   20


<210>  33462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33462
aggccagagc gagggucugu                                                   20


<210>  33463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33463
guuggaugau acgggcucag                                                   20


<210>  33464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33464
gcuagugaag auuaaagauu                                                   20


<210>  33465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33465
cuagcagaac auucuguugg                                                   20


<210>  33466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33466
cucuuguugc ccaggcugga                                                   20


<210>  33467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33467
aacuauucuc cugccucagc                                                   20


<210>  33468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33468
ccugccucag ccucucgagu                                                   20


<210>  33469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33469
ccauguuggu caggcugguc                                                   20


<210>  33470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33470
agaccagccu gaccaacaug                                                   20


<210>  33471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33471
aauacaauaa auccuggcca                                                   20


<210>  33472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33472
uuaucaucaa auacuacaua                                                   20


<210>  33473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33473
uuccauuuuu cuguuuaagu                                                   20


<210>  33474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33474
auuuuucugu uuaagugaau                                                   20


<210>  33475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33475
guuuaaguga augaccugua                                                   20


<210>  33476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33476
cuuaaacaga aaaauggaaa                                                   20


<210>  33477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33477
guaacuuccu gcauauauuu                                                   20


<210>  33478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33478
ugcauauauu uguuucuuuc                                                   20


<210>  33479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33479
uucauucuua augaauauau                                                   20


<210>  33480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33480
uucuuaauga auauauucuu                                                   20


<210>  33481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33481
uaaugaauau auucuuaauu                                                   20


<210>  33482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33482
uuaagaauga aagaaacaaa                                                   20


<210>  33483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33483
uaauuuaguu gcuauuaugu                                                   20


<210>  33484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33484
auuuuggggc aaagcaaaac                                                   20


<210>  33485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33485
uuuuagcucg uuuuagaacu                                                   20


<210>  33486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33486
aaaacgagcu aaaaggaaac                                                   20


<210>  33487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33487
auaaaucucu ugugauuugu                                                   20


<210>  33488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33488
aaucuuccaa gguuacagcu                                                   20


<210>  33489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33489
aagguuacag cucgagcucu                                                   20


<210>  33490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33490
uuauagagcu cgagcuguaa                                                   20


<210>  33491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33491
uuuuuaaaaa uguuuuaaau                                                   20


<210>  33492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33492
auggugugau uauuauguau                                                   20


<210>  33493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33493
cccaugcuag aguacagugg                                                   20


<210>  33494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33494
accgaacuuu gggcuggucu                                                   20


<210>  33495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33495
guugaacccg ggaggcggag                                                   20


<210>  33496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33496
agaccagccu ggccaacaug                                                   20


<210>  33497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33497
ccauguuggc caggcugguc                                                   20


<210>  33498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33498
ccuaccucag ccucccgagu                                                   20


<210>  33499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33499
agcgauuccc cuaccucagc                                                   20


<210>  33500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33500
agccugagcg acagagugag                                                   20


<210>  33501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33501
uuuuuauuuu uugagacaaa                                                   20


<210>  33502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33502
caaagugcug ggacuaaggu                                                   20


<210>  33503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33503
guacagacag cguuuugcca                                                   20


<210>  33504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33504
aggcucaauu aauccuccca                                                   20


<210>  33505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33505
accuuccagg cucaauuaau                                                   20


<210>  33506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33506
gccugggcga ccaagugaga                                                   20


<210>  33507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33507
uuugagacag ggucucacuu                                                   20


<210>  33508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33508
acagcacagc agagggauca                                                   20


<210>  33509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33509
aucacugagc aaacuucacu                                                   20


<210>  33510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33510
cucuguuaag cagcaggugu                                                   20


<210>  33511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33511
ucguuauuca guaauucaca                                                   20


<210>  33512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33512
guaauucaca auguuagaag                                                   20


<210>  33513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33513
caauguuaga aggaaaugcu                                                   20


<210>  33514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33514
aacauuguga auuacugaau                                                   20


<210>  33515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33515
uucuaacauu gugaauuacu                                                   20


<210>  33516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33516
ucaaaagguu acucuuuauu                                                   20


<210>  33517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33517
aaagguuacu cuuuauuaga                                                   20


<210>  33518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33518
caucucaucu aauaaagagu                                                   20


<210>  33519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33519
auuauaaaga uauaaaguaa                                                   20


<210>  33520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33520
cuaaaauuag aaaguaacaa                                                   20


<210>  33521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33521
aauuuuagag aaaaggccau                                                   20


<210>  33522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33522
uuguuacuuu cuaauuuuag                                                   20


<210>  33523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33523
uuccuuguua cuuucuaauu                                                   20


<210>  33524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33524
uuucuaugca acccucuugg                                                   20


<210>  33525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33525
augcaacccu cuuggugacu                                                   20


<210>  33526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33526
gagggggugc aaugaggguu                                                   20


<210>  33527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33527
gccucagaaa ugcagguaag                                                   20


<210>  33528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33528
gaggccgaac caggugagcc                                                   20


<210>  33529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33529
aaagucugcu cugcccucuc                                                   20


<210>  33530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33530
cucauagcac uaauccaugu                                                   20


<210>  33531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33531
gacauggauu agugcuauga                                                   20


<210>  33532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33532
aucccacccu uccgcaagag                                                   20


<210>  33533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33533
gcaagagacu uaugggaugu                                                   20


<210>  33534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33534
acaauuuggc aaguaucuuu                                                   20


<210>  33535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33535
uuauugcuga cuauaggagu                                                   20


<210>  33536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33536
cagugcaaca accauauuuu                                                   20


<210>  33537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33537
caauccguua agauacaacu                                                   20


<210>  33538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33538
ucagcucccu ccuucuccuu                                                   20


<210>  33539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33539
ccuuaaccag caauacaugc                                                   20


<210>  33540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33540
cagugacuca ggauggagcu                                                   20


<210>  33541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33541
uauuaauagu gaggguuuag                                                   20


<210>  33542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33542
auaagaaucu uauauggguc                                                   20


<210>  33543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33543
uauugaaacu caguucauau                                                   20


<210>  33544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33544
ggaggccaag gcagguggau                                                   20


<210>  33545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33545
ccauguugcc uagucugggu                                                   20


<210>  33546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33546
ggauuuuggu uuuuuugaga                                                   20


<210>  33547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33547
uuucuggauu uugguuuuuu                                                   20


<210>  33548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33548
uuagugauua uaccucugca                                                   20


<210>  33549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33549
uuuuguauaa ucuuuuuucu                                                   20


<210>  33550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33550
uuuacuauca uuuaaaaaaa                                                   20


<210>  33551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33551
gaagcaacac auccagguuc                                                   20


<210>  33552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33552
gaaauauaac acauuuuuuu                                                   20


<210>  33553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33553
gcacauagca gccaaaguga                                                   20


<210>  33554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33554
uuaaggucac uuuggcugcu                                                   20


<210>  33555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33555
cuuauuuaaa cucuuguacc                                                   20


<210>  33556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33556
cagugccguu uagauagaga                                                   20


<210>  33557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33557
agacucguca auggcucugu                                                   20


<210>  33558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33558
uccuccugau gguuuuuuuu                                                   20


<210>  33559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33559
uccugauggu uuuuuuuucc                                                   20


<210>  33560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33560
cccuuaguuc ucagcggaac                                                   20


<210>  33561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33561
cagcggaaca gucacuuccu                                                   20


<210>  33562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33562
gcugagaacu aagggggaaa                                                   20


<210>  33563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33563
uuagggaggu uuccccagcc                                                   20


<210>  33564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33564
ccagccaccc ucugaggccg                                                   20


<210>  33565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33565
cccaacacac agagugacag                                                   20


<210>  33566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33566
ugugaucugu gacucacugc                                                   20


<210>  33567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33567
gcuuuucuuc ucuccccaca                                                   20


<210>  33568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33568
ucucucccca caaccccauu                                                   20


<210>  33569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33569
cuccccacaa ccccauuuua                                                   20


<210>  33570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33570
ccuuuuucag gaaagcuuua                                                   20


<210>  33571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33571
ggaaagcuuu auucccauuu                                                   20


<210>  33572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33572
ugaaaaagga gaauuauaaa                                                   20


<210>  33573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33573
cauuuaaaaa uuuuuguuuu                                                   20


<210>  33574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33574
uacacuuauu uucuaauuaa                                                   20


<210>  33575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33575
aauuaaaaau gaguguuuua                                                   20


<210>  33576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33576
uaaaacacuc auuuuuaauu                                                   20


<210>  33577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33577
cuuaugauca cagaggaucu                                                   20


<210>  33578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33578
uuucucuuau gaucacagag                                                   20


<210>  33579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33579
uccacauuuc auccuccugu                                                   20


<210>  33580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33580
uccuccuguu cuuucagcug                                                   20


<210>  33581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33581
uucagcugag uuuuccccau                                                   20


<210>  33582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33582
gcugaguuuu ccccauccca                                                   20


<210>  33583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33583
ccaucccauu agggacuguu                                                   20


<210>  33584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33584
aacagucccu aaugggaugg                                                   20


<210>  33585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33585
cuaacaggga augaauugcu                                                   20


<210>  33586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33586
cuguuaggga aaagccaguu                                                   20


<210>  33587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33587
uucccuguua gggaaaagcc                                                   20


<210>  33588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33588
guuucuccug aaggagagcu                                                   20


<210>  33589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33589
ccugaaggag agcuggaaga                                                   20


<210>  33590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33590
ggagaaacag aagcaauuca                                                   20


<210>  33591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33591
agcucuccuu caggagaaac                                                   20


<210>  33592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33592
uccagcucuc cuucaggaga                                                   20


<210>  33593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33593
uuugcauaca caggccuuac                                                   20


<210>  33594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33594
ccagguaagg ccuguguaug                                                   20


<210>  33595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33595
gccgugccug acucgaacaa                                                   20


<210>  33596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33596
agucaggcac ggcagaaggu                                                   20


<210>  33597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33597
ggucucuugc uuguucgagu                                                   20


<210>  33598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33598
ucgggucucu ugcuuguucg                                                   20


<210>  33599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33599
caaaauuaug gcuucuuuug                                                   20


<210>  33600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33600
uuuggcaauu uugcaaauga                                                   20


<210>  33601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33601
uugucauuug caaaauugcc                                                   20


<210>  33602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33602
gaacagggag uccuguggga                                                   20


<210>  33603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33603
gaagcccuca cccuccacag                                                   20


<210>  33604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33604
ugggguaugu uguaugucgu                                                   20


<210>  33605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33605
uuccacuucu cauuucuuac                                                   20


<210>  33606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33606
acuucucauu ucuuacugug                                                   20


<210>  33607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33607
cauuucuuac ugugggguga                                                   20


<210>  33608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33608
uacugugggg ugaagaguug                                                   20


<210>  33609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33609
ccccacagua agaaaugaga                                                   20


<210>  33610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33610
acucuucacc ccacaguaag                                                   20


<210>  33611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33611
agaugcaaau ugaaaaggca                                                   20


<210>  33612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33612
auuugcaucu agaaaccauc                                                   20


<210>  33613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33613
agagcagauu uguuuucggc                                                   20


<210>  33614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33614
gcguacuaga gugacucuuu                                                   20


<210>  33615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33615
cgcagcuagg uuaaagaguc                                                   20


<210>  33616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33616
ccuaccugca gucuuggcac                                                   20


<210>  33617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33617
gacccacaag gccucgucag                                                   20


<210>  33618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33618
uguugugcau uccaacaaau                                                   20


<210>  33619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33619
aacaaaucau cuucaaaccc                                                   20


<210>  33620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33620
aacccacuuu aguguuuugu                                                   20


<210>  33621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33621
ggacauuaua aacaaaacac                                                   20


<210>  33622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33622
uagccucuuc cuuuuuggua                                                   20


<210>  33623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33623
uuuuugguag gucaguccug                                                   20


<210>  33624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33624
acucuaccca guguguauca                                                   20


<210>  33625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33625
aauccaaguc caucugauuc                                                   20


<210>  33626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33626
guccucuuua cuaguuauuu                                                   20


<210>  33627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33627
ucuaggcaaa cugcccaaca                                                   20


<210>  33628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33628
uucguauucu gaaaaauaag                                                   20


<210>  33629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33629
uauucugaaa aauaagccuu                                                   20


<210>  33630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33630
gaaaaauaag ccuuaauggg                                                   20


<210>  33631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33631
gaauacgaag gaaauagcuu                                                   20


<210>  33632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33632
uuuauuuuac ucucagaguu                                                   20


<210>  33633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33633
cgugggugac uaugcuacac                                                   20


<210>  33634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33634
gcuaauaaga gcaguagcag                                                   20


<210>  33635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33635
aaaucauuca gcuaauaaga                                                   20


<210>  33636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33636
cuugagcuuc gaaguuuucu                                                   20


<210>  33637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33637
aaguuuucuu guuaauacua                                                   20


<210>  33638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33638
aagcucaaga gaaaaaacau                                                   20


<210>  33639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33639
uguuaauacu aaggagauau                                                   20


<210>  33640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33640
aacuagucau gggguuuugg                                                   20


<210>  33641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33641
aaaaccccau gacuaguuug                                                   20


<210>  33642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33642
ucauuccaaa accccaugac                                                   20


<210>  33643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33643
ucaucucccu ucgucauucc                                                   20


<210>  33644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33644
uuagauucau caucucccuu                                                   20


<210>  33645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33645
ucaugcucag uaaaugguag                                                   20


<210>  33646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33646
ugcucaguaa augguaguuu                                                   20


<210>  33647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33647
gcugcuguua uuuuuauuac                                                   20


<210>  33648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33648
aaagagaugg uaauaaaaau                                                   20


<210>  33649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33649
acagacccca guguacagau                                                   20


<210>  33650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33650
caucauuuuc augauuucga                                                   20


<210>  33651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33651
ugauuucgau caccauuuga                                                   20


<210>  33652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33652
aucaccauuu gaguaugaug                                                   20


<210>  33653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33653
acaaaguguu agcaucauca                                                   20


<210>  33654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33654
acguucaaca aaguguuagc                                                   20


<210>  33655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33655
uuccugaacc uuuggcauua                                                   20


<210>  33656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33656
ugaaccuuug gcauuaaaaa                                                   20


<210>  33657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33657
ggaaggaagu aauuaacgga                                                   20


<210>  33658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33658
gcuaccucuc ugcucauuua                                                   20


<210>  33659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33659
aauuuauuau caagagccug                                                   20


<210>  33660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33660
guuuuuuuag agauaggguc                                                   20


<210>  33661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33661
aggcuacacu gagcugugau                                                   20


<210>  33662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33662
uaaaaaaaaa aaauauauau                                                   20


<210>  33663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33663
uugauaauau auauauauau                                                   20


<210>  33664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33664
guaguaccaa caggauuaua                                                   20


<210>  33665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33665
cuuccuacuu uuucucuuaa                                                   20


<210>  33666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33666
uacuuuuucu cuuaauccuu                                                   20


<210>  33667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33667
cuuaauccuu gugucucaca                                                   20


<210>  33668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33668
uccaauauuu acuuucaugu                                                   20


<210>  33669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33669
aauauuuacu uucauguuuc                                                   20


<210>  33670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33670
uguuucuuuc uuucuuucuu                                                   20


<210>  33671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33671
uucuuucuuu cuuuuuuuuu                                                   20


<210>  33672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33672
uucuuucuuu uuuuuucuuu                                                   20


<210>  33673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33673
uucuuuuuuu uucuuugaga                                                   20


<210>  33674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33674
uuuuuuuucu uugagaugga                                                   20


<210>  33675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33675
uugagaugga guuuugcucu                                                   20


<210>  33676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33676
agcgauucuc cugccucagc                                                   20


<210>  33677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33677
ccugccucag ccuccuagua                                                   20


<210>  33678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33678
ccggguuggu caggcugguc                                                   20


<210>  33679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33679
agaccagccu gaccaacccg                                                   20


<210>  33680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33680
acauuucuaa auaacaugcu                                                   20


<210>  33681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33681
aaauaacaug cuucuacugc                                                   20


<210>  33682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33682
acugcuauuu uuuuuuucaa                                                   20


<210>  33683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33683
auuuuagaca uuuuuuuacu                                                   20


<210>  33684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33684
cuauaguucu aucagaauuc                                                   20


<210>  33685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33685
aucagaauuc aguguguacg                                                   20


<210>  33686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33686
gauagaacua uagugaaagu                                                   20


<210>  33687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33687
guguguacgu uauuaugccu                                                   20


<210>  33688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33688
uugauugugu uucuuauuug                                                   20


<210>  33689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33689
uauuugauga gaaagcugug                                                   20


<210>  33690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33690
caucaaauaa gaaacacaau                                                   20


<210>  33691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33691
acccagagca aaaaacacag                                                   20


<210>  33692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33692
ucuguccucc uccuccuccc                                                   20


<210>  33693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33693
uggccauagc uggguucuca                                                   20


<210>  33694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33694
cagcacccgg ggaucugcug                                                   20


<210>  33695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33695
auaggggccu ggccuaugag                                                   20


<210>  33696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33696
aggugaccca gugcugggga                                                   20


<210>  33697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33697
uaaggaugcu ggccccagca                                                   20


<210>  33698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33698
ugauuggggc cuucagcagc                                                   20


<210>  33699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33699
gcagcaccag cuucuugggc                                                   20


<210>  33700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33700
ugggcaggcu ggugcuggcu                                                   20


<210>  33701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33701
ucaccauguc guguucaauc                                                   20


<210>  33702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33702
aucuucuucc agauccugac                                                   20


<210>  33703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33703
uccagauccu gacuucuagg                                                   20


<210>  33704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33704
agauccugac uucuagguuc                                                   20


<210>  33705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33705
agguucagcu uuccucagac                                                   20


<210>  33706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33706
gcuuuccuca gacccugguu                                                   20


<210>  33707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33707
ucagacccug guuccuuuca                                                   20


<210>  33708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33708
uuucagaggc cauugcugcu                                                   20


<210>  33709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33709
gaggccauug cugcugccuu                                                   20


<210>  33710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33710
uggaguuaau cuucacaucu                                                   20


<210>  33711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33711
caucuguuuu cuuggaguua                                                   20


<210>  33712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33712
uggaguuaau cguuaccucu                                                   20


<210>  33713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33713
uuggccuuuu ugucuucuca                                                   20


<210>  33714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33714
cacaccuucc aacuucuuug                                                   20


<210>  33715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33715
aacuucuuug uaauaugugu                                                   20


<210>  33716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33716
uuguaauaug uguuuaguac                                                   20


<210>  33717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33717
ugacagguag uuuacugaau                                                   20


<210>  33718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33718
guaaacuacc ugucaugaaa                                                   20


<210>  33719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33719
ccaguguggu cauccaacuu                                                   20


<210>  33720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33720
ggucuguagu acacuuguau                                                   20


<210>  33721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33721
cuuugccauu agccuggaau                                                   20


<210>  33722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33722
aggcuaaugg caaagagaag                                                   20


<210>  33723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33723
uuugcaguuc ucccguugga                                                   20


<210>  33724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33724
cccguuggau gcccaguucc                                                   20


<210>  33725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33725
uagaugccau auguuuuucu                                                   20


<210>  33726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33726
aucgucuagu agcuuccuga                                                   20


<210>  33727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33727
ugagagaaga ugaaugggag                                                   20


<210>  33728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33728
cucaggaagc uacuagacga                                                   20


<210>  33729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33729
ucuucucuca ggaagcuacu                                                   20


<210>  33730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33730
cucccauuca ucuucucuca                                                   20


<210>  33731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33731
uaaaaaugcc auuuuuuuuc                                                   20


<210>  33732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33732
uguacacuug gcuggguaug                                                   20


<210>  33733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33733
gggguagaaa ucauuuuccc                                                   20


<210>  33734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33734
accccagaac accauaccca                                                   20


<210>  33735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33735
cucagaaaug caaagucuuu                                                   20


<210>  33736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33736
gagggaaaau gauuucuacc                                                   20


<210>  33737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33737
uuaaccuaug aauguacuuu                                                   20


<210>  33738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33738
uagguuaagg aaucggguca                                                   20


<210>  33739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33739
uuggaagcuu uccauuuuug                                                   20


<210>  33740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33740
aaagaaaagu acauucauag                                                   20


<210>  33741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33741
auuuuugggg aggugaagug                                                   20


<210>  33742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33742
ccuccccaaa aauggaaagc                                                   20


<210>  33743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33743
aaauuaaaag gccuacuaag                                                   20


<210>  33744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33744
guucugggaa aauuuucuua                                                   20


<210>  33745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33745
gggaaaauuu ucuuaacauu                                                   20


<210>  33746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33746
cagaacugaa gggauguaag                                                   20


<210>  33747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33747
uaacauuucu cugagaaguu                                                   20


<210>  33748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33748
cugagaaguu cuugccuuuu                                                   20


<210>  33749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33749
cagagaaaug uuaagaaaau                                                   20


<210>  33750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33750
ugccuuuuau uuucuguguu                                                   20


<210>  33751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33751
guguucucuc cugaaauugg                                                   20


<210>  33752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33752
cuccugaaau ugguuaguug                                                   20


<210>  33753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33753
ggagagaaca cagaaaauaa                                                   20


<210>  33754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33754
uuucuuuuuc ugguacuuuu                                                   20


<210>  33755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33755
uuuucuggua cuuuuuagau                                                   20


<210>  33756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33756
gguacuuuuu agauauccau                                                   20


<210>  33757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33757
auucauuguu auguuuuuaa                                                   20


<210>  33758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33758
uuguuauguu uuuaacuucu                                                   20


<210>  33759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33759
uucuuuucuu ugucucuuga                                                   20


<210>  33760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33760
uuucuuuguc ucuugauggg                                                   20


<210>  33761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33761
uugucucuug auggggucuu                                                   20


<210>  33762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33762
ugggcucaag cagcuguucu                                                   20


<210>  33763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33763
gccucacccu cccaaguagu                                                   20


<210>  33764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33764
uuacuuuuuu uuuuuuuuuu                                                   20


<210>  33765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33765
agcaguucuc cugccucagc                                                   20


<210>  33766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33766
ccugccucag ccucucaagu                                                   20


<210>  33767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33767
ccauguuggc caggcugguc                                                   20


<210>  33768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33768
agaccagccu ggccaacaug                                                   20


<210>  33769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33769
gaggccaagg caggcggauc                                                   20


<210>  33770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33770
ucuugaguca gcuaguaucc                                                   20


<210>  33771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33771
agggauacua gcugacucaa                                                   20


<210>  33772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33772
uuccagggau acuagcugac                                                   20


<210>  33773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33773
ugcuuggagg cuauaagcuu                                                   20


<210>  33774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33774
aguccccggu ugcaggauaa                                                   20


<210>  33775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33775
gugugcaucu cacgucuguc                                                   20


<210>  33776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33776
ugggcugccu uggauuggag                                                   20


<210>  33777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33777
cuccaaucca aggcagccca                                                   20


<210>  33778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33778
cacccacuca ccugaggucu                                                   20


<210>  33779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33779
cccucuccau cccuccacuu                                                   20


<210>  33780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33780
gauguaugug gcgccuccaa                                                   20


<210>  33781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33781
uggcgucugu ggcuucaaua                                                   20


<210>  33782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33782
auaagcuugc uuuuugcugg                                                   20


<210>  33783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33783
aaugcaagcu uugcugggga                                                   20


<210>  33784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33784
uccuacgggc uaacaaauca                                                   20


<210>  33785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33785
uacgggcuaa caaaucaguc                                                   20


<210>  33786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33786
gaaguuuugu ugacacccgu                                                   20


<210>  33787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33787
gaagcuaaaa aguaacaaga                                                   20


<210>  33788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33788
guucuuucug uucguguaaa                                                   20


<210>  33789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33789
uucuguucgu guaaauauau                                                   20


<210>  33790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33790
guucguguaa auauaugcuu                                                   20


<210>  33791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33791
uguaaauaua ugcuuuauac                                                   20


<210>  33792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33792
uuacaugauu uuuguggggu                                                   20


<210>  33793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33793
ggguagcaga gcuucacaag                                                   20


<210>  33794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33794
caaguucaau ccagcguguu                                                   20


<210>  33795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33795
auccagcgug uuggauuaga                                                   20


<210>  33796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33796
aauccaacac gcuggauuga                                                   20


<210>  33797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33797
uauucucaaa auuaccugcc                                                   20


<210>  33798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33798
caaaauuacc ugccaaacac                                                   20


<210>  33799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33799
uuuuccugac aggaaaugua                                                   20


<210>  33800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33800
ugacaggaaa uguacauacc                                                   20


<210>  33801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33801
ugucaggaaa aggaaaaaca                                                   20


<210>  33802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33802
guccuguaug guauguacau                                                   20


<210>  33803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33803
ccaagggaua cacuaaugau                                                   20


<210>  33804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33804
cuuugugguu auucaccaag                                                   20


<210>  33805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33805
gucuugaccu ggguggcggu                                                   20


<210>  33806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33806
gagugcuugg uaauauucug                                                   20


<210>  33807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33807
cccgucacug cuccugccuu                                                   20


<210>  33808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33808
uccccaaggu caugacugcu                                                   20


<210>  33809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33809
aauuccagag ucuguuuuua                                                   20


<210>  33810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33810
agagucuguu uuuaaauucu                                                   20


<210>  33811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33811
guguacauag accauggauu                                                   20


<210>  33812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33812
uuuugucugg uuuauuuugg                                                   20


<210>  33813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33813
ugagagucuu cuauauuauc                                                   20


<210>  33814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33814
auauuaucgu guguauuagu                                                   20


<210>  33815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33815
uguaguuuua ggagcuucau                                                   20


<210>  33816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33816
uagcauucca uuguagggau                                                   20


<210>  33817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33817
auuguaggga uauaccacag                                                   20


<210>  33818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33818
uuguauuauc acuggguugu                                                   20


<210>  33819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33819
aguucuuggc uauugcgagc                                                   20


<210>  33820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33820
uggcuauugc gagcagugcu                                                   20


<210>  33821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33821
aucuugcaca gcuagaggug                                                   20


<210>  33822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33822
acugcagcug agaugcacac                                                   20


<210>  33823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33823
uugagugcuu guaccagcuc                                                   20


<210>  33824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33824
aggagcucug guccucgcua                                                   20


<210>  33825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33825
aagugcuagc gaggaccaga                                                   20


<210>  33826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33826
ugaugggugu uuucuggaau                                                   20


<210>  33827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33827
ggaaucacau uaugauuuua                                                   20


<210>  33828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33828
agaaaacacc caucaggaag                                                   20


<210>  33829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33829
auuccuuaaa guacccuugg                                                   20


<210>  33830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33830
uuaaaguacc cuuggcucug                                                   20


<210>  33831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33831
gagccaaggg uacuuuaagg                                                   20


<210>  33832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33832
ugcaucucuu cccuuuugaa                                                   20


<210>  33833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33833
cuuuugaagu acucuuacag                                                   20


<210>  33834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33834
aaagggaaga gaugcaugaa                                                   20


<210>  33835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33835
acacaugcac aacauaccug                                                   20


<210>  33836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33836
aaaauacagu augccuccuc                                                   20


<210>  33837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33837
aacacagagg aggcauacug                                                   20


<210>  33838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33838
ccaagccagc uaacaggagg                                                   20


<210>  33839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33839
ugggauugua gagauuagac                                                   20


<210>  33840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33840
uuauuauucc aaacuauuua                                                   20


<210>  33841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33841
aaacuauuua agcucaccgu                                                   20


<210>  33842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33842
uugagacaga gucuugcucu                                                   20


<210>  33843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33843
agugauucuu gugccucagc                                                   20


<210>  33844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33844
ugugccucag cuucucaagu                                                   20


<210>  33845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33845
caaguagcug agacugcagg                                                   20


<210>  33846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33846
ccauguuggc cagguugguc                                                   20


<210>  33847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33847
ucagccuccc aaagugcugg                                                   20


<210>  33848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33848
gccucccaaa gugcugggau                                                   20


<210>  33849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33849
ugcagcuaaa aaaguuuguc                                                   20


<210>  33850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33850
acuuuguucu ccagguguuu                                                   20


<210>  33851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33851
ccagguguuu ucucagggag                                                   20


<210>  33852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33852
cagggagaaa uuggaggcag                                                   20


<210>  33853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33853
cccugagaaa acaccuggag                                                   20


<210>  33854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33854
cuccuugcca gccacaggac                                                   20


<210>  33855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33855
ucuagcgcug cuggguuagg                                                   20


<210>  33856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33856
gugugugugu cuuuaauucc                                                   20


<210>  33857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33857
caccucuaua uuucugugug                                                   20


<210>  33858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33858
cacuucacac cucuauauuu                                                   20


<210>  33859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33859
gggcucucag cucuaaaggc                                                   20


<210>  33860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33860
auagauguua aauuaacuaa                                                   20


<210>  33861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33861
cauaagggau acuuuuaguu                                                   20


<210>  33862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33862
gcccaucccc ucguuuccca                                                   20


<210>  33863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33863
uuuaauucgg cccauccccu                                                   20


<210>  33864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33864
uaagccacaa acaauagcau                                                   20


<210>  33865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33865
acccugggug ggccaggugu                                                   20


<210>  33866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33866
uugcccucau uccugucaac                                                   20


<210>  33867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33867
ugucaaccca caaccuucca                                                   20


<210>  33868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33868
agugugggca uuagggccau                                                   20


<210>  33869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33869
uaauggcccu aaugcccaca                                                   20


<210>  33870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33870
gagauuuugu uuauggccag                                                   20


<210>  33871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33871
cugggaggcg auaagccucu                                                   20


<210>  33872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33872
cagaggcuua ucgccuccca                                                   20


<210>  33873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33873
uggcgugguu agcauagucu                                                   20


<210>  33874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33874
cuuucauggc gugguuagca                                                   20


<210>  33875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33875
gcaugcacug agcaagcacu                                                   20


<210>  33876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33876
aaucauuguu cagcaugcac                                                   20


<210>  33877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33877
aaacuaugcu cugagccaug                                                   20


<210>  33878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33878
cauuauucaa aacuaugcuc                                                   20


<210>  33879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33879
uaaguaacau agucaccaag                                                   20


<210>  33880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33880
auuuuaggau auuuuuauca                                                   20


<210>  33881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33881
ccuuuggauu guccuagagg                                                   20


<210>  33882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33882
caugggccuc uaggacaauc                                                   20


<210>  33883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33883
cuaauuucuu aggagaacag                                                   20


<210>  33884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33884
uaggagaaca guuugugggu                                                   20


<210>  33885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33885
ccuaagaaau uagggaauac                                                   20


<210>  33886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33886
gaucgaagau guuccagucc                                                   20


<210>  33887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33887
aucggaaaua ucugcaauuu                                                   20


<210>  33888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33888
aguccugaga acuucgugac                                                   20


<210>  33889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33889
caggacugga acaucuucga                                                   20


<210>  33890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33890
ugacauuagc aggacuucua                                                   20


<210>  33891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33891
acaagccauc ucuuagggug                                                   20


<210>  33892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33892
ccuuaacuuu gucauuuguu                                                   20


<210>  33893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33893
agauacacuc ugcccacagu                                                   20


<210>  33894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33894
cucaggggac ugcucagcau                                                   20


<210>  33895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33895
uuauaaccuu cacucagggg                                                   20


<210>  33896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33896
guucagcugu aggaaaagcc                                                   20


<210>  33897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33897
gcuguaggaa aagccucaaa                                                   20


<210>  33898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33898
uacagcugaa cugaaguacc                                                   20


<210>  33899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33899
ugcaaaguau aaacaguuug                                                   20


<210>  33900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33900
aauucuugca aaguauaaac                                                   20


<210>  33901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33901
aauucacguu aaguuuuaug                                                   20


<210>  33902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33902
cguuaaguuu uauguaauac                                                   20


<210>  33903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33903
uaggagcuuc aucuuuuauc                                                   20


<210>  33904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33904
ucuuuuaucu acuuggacuu                                                   20


<210>  33905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33905
guagguuuug uuaaaggccu                                                   20


<210>  33906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33906
uagcgaaccu gaagucaagc                                                   20


<210>  33907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33907
cuaugaaggc cuuuaacaaa                                                   20


<210>  33908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33908
gguucgcuau gaaggccuuu                                                   20


<210>  33909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33909
gcggacagcg gcuggaucag                                                   20


<210>  33910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33910
ugagugcugg cagaugcuca                                                   20


<210>  33911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33911
auaguuggcu acuaaaugug                                                   20


<210>  33912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33912
acucauaugc cuccaccuua                                                   20


<210>  33913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33913
aaggucuauc uugaguacau                                                   20


<210>  33914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33914
agaccaggcu auuuggcacu                                                   20


<210>  33915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33915
aucaaccagu gccaaauagc                                                   20


<210>  33916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33916
cauucaauca accagugcca                                                   20


<210>  33917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33917
ugcggguucu cuguagguca                                                   20


<210>  33918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33918
cuguagguca guugacaguu                                                   20


<210>  33919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33919
ccuguuguuu ggguaacugu                                                   20


<210>  33920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33920
acaguuaccc aaacaacagg                                                   20


<210>  33921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33921
uuuccacagu uacccaaaca                                                   20


<210>  33922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33922
gcacuugcca guguucguuu                                                   20


<210>  33923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33923
uaucgcacgu ccacaugcuc                                                   20


<210>  33924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33924
aaggcaguga ggcucucugg                                                   20


<210>  33925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33925
agagagccuc acugccuuug                                                   20


<210>  33926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33926
cagugggccu cauggcguac                                                   20


<210>  33927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33927
ugaucauguu ugugccaucu                                                   20


<210>  33928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33928
uuuuuaacag auuaagccgg                                                   20


<210>  33929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33929
cggcuuaauc uguuaaaaaa                                                   20


<210>  33930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33930
acccccacag gcuuacucgu                                                   20


<210>  33931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33931
ugucgaggau gaacacucca                                                   20


<210>  33932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33932
uccucgacag gaacgaguaa                                                   20


<210>  33933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33933
uggcgugcug cucacccuga                                                   20


<210>  33934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33934
ggcuuguguc cuugaccugc                                                   20


<210>  33935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33935
gagugacaag gaaagaaaug                                                   20


<210>  33936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33936
uugucacucc gaagcugccu                                                   20


<210>  33937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33937
uuccuuguca cuccgaagcu                                                   20


<210>  33938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33938
auuucuuucc uugucacucc                                                   20


<210>  33939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33939
gcagagcagc uuguccaggu                                                   20


<210>  33940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33940
caugcagggc cuagaguaaa                                                   20


<210>  33941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33941
aagaaccgau uaauuuggaa                                                   20


<210>  33942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33942
uugaauguca gucauucaca                                                   20


<210>  33943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33943
aaauuaaucg guucuuugaa                                                   20


<210>  33944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33944
cuuccaaauu aaucgguucu                                                   20


<210>  33945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33945
gccgcuucuc uuccaaauua                                                   20


<210>  33946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33946
aacccuaggu gcugaccucu                                                   20


<210>  33947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33947
cucuguaugu cccugucacc                                                   20


<210>  33948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33948
aaaaccagag gucacgauau                                                   20


<210>  33949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33949
uccacccagu aaauacugau                                                   20


<210>  33950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33950
gcugcagcuu cugccccgug                                                   20


<210>  33951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33951
gccccgugga ggcuguggcc                                                   20


<210>  33952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33952
gacaccccaa acgaccacgu                                                   20


<210>  33953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33953
gacauuuugu uccgacaccc                                                   20


<210>  33954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33954
cuuuccaaug cagagaaacc                                                   20


<210>  33955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33955
aaugcagaga aaccuugcag                                                   20


<210>  33956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33956
cugcauugga aagagaaguu                                                   20


<210>  33957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33957
aauguacugu gauuggcagu                                                   20


<210>  33958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33958
guucuuugua gcacgcuuac                                                   20


<210>  33959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33959
uuguagcacg cuuacucagg                                                   20


<210>  33960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33960
cuaacuaugu aaccaugcag                                                   20


<210>  33961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33961
aaaaauccaa uugcuuaaaa                                                   20


<210>  33962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33962
uauccuacaa aacuuagcua                                                   20


<210>  33963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33963
uaauagaauc augaauugaa                                                   20


<210>  33964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33964
auuaagaauc auuuuaagcc                                                   20


<210>  33965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33965
ugauucuauu aagaaucauu                                                   20


<210>  33966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33966
auucaugauu cuauuaagaa                                                   20


<210>  33967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33967
aagcauuuua caaacacuac                                                   20


<210>  33968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33968
uggcacaugu uaaggccaug                                                   20


<210>  33969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33969
uaagagucca cuuuugcuca                                                   20


<210>  33970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33970
guuccaacca gcugcccuuu                                                   20


<210>  33971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33971
aaccagcugc ccuuugguua                                                   20


<210>  33972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33972
gaauaaaagc agagucucau                                                   20


<210>  33973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33973
gaaaaauaac caaagggcag                                                   20


<210>  33974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33974
uucacaaaaa acacugcuga                                                   20


<210>  33975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33975
caaaaaacac ugcugagugu                                                   20


<210>  33976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33976
ucuuuaccuu gccuuguuuu                                                   20


<210>  33977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33977
caauaaaaag cuagcuuaaa                                                   20


<210>  33978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33978
acacauacaa aaguaucaac                                                   20


<210>  33979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33979
uuuauaaucc uacuucuccc                                                   20


<210>  33980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33980
cccuuuuuuu auuauuugaa                                                   20


<210>  33981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33981
aauaauaaaa aaagggagaa                                                   20


<210>  33982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33982
ucuauaagua uuucaguauc                                                   20


<210>  33983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33983
guaucucuau agaugaggac                                                   20


<210>  33984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33984
uuauuuuuaa aacuuuauuu                                                   20


<210>  33985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33985
ugccuguaau cccagaacuu                                                   20


<210>  33986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33986
gggauuacag gcaugaacac                                                   20


<210>  33987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33987
agugauccgc ccagcuuggc                                                   20


<210>  33988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33988
cgggcugguc ucaaacuccc                                                   20


<210>  33989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33989
ccauguuucc cgggcugguc                                                   20


<210>  33990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33990
uuaagacaug ggguuucgcc                                                   20


<210>  33991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33991
aggcucaugu gacccuccca                                                   20


<210>  33992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33992
gucucaaaaa aacaaaacug                                                   20


<210>  33993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33993
ggucuaacaa uggcacuguu                                                   20


<210>  33994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33994
uacaucaaau acccaccaac                                                   20


<210>  33995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33995
cucuacucuu uuggaaucag                                                   20


<210>  33996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33996
aaaagaguag agagaaaaau                                                   20


<210>  33997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33997
ucaaagagau uuacaauccu                                                   20


<210>  33998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33998
ccuccauccc aguuuuuuuc                                                   20


<210>  33999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  33999
cuuagaguuc auuuauugag                                                   20


<210>  34000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34000
uuuauugaga aaccagauug                                                   20


<210>  34001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34001
caauaaauga acucuaaggg                                                   20


<210>  34002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34002
aaguuuuccu guggucugau                                                   20


<210>  34003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34003
uguggucuga uauacugcuu                                                   20


<210>  34004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34004
aucuccacug uguaaauuaa                                                   20


<210>  34005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34005
cuucucugua uuuccuguaa                                                   20


<210>  34006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34006
cuguauuucc uguaaaucaa                                                   20


<210>  34007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34007
uguaaaucaa uaauuggagg                                                   20


<210>  34008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34008
uccaauuauu gauuuacagg                                                   20


<210>  34009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34009
uauauaauau uuuaagauaa                                                   20


<210>  34010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34010
auacuuuuua aaagaguaca                                                   20


<210>  34011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34011
uaaaagcauc aguuaaaaaa                                                   20


<210>  34012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34012
caucagacca augaucucua                                                   20


<210>  34013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34013
ccaggcccca ccaugugcac                                                   20


<210>  34014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34014
gucaugagcc gucacuuaug                                                   20


<210>  34015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34015
acgugcccau aagugacggc                                                   20


<210>  34016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34016
cccaacucug ugccggguca                                                   20


<210>  34017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34017
gucuauaaag cuccugucuu                                                   20


<210>  34018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34018
cuccugggac uuagcaaaga                                                   20


<210>  34019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34019
ggacccaccc uugcucuguc                                                   20


<210>  34020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34020
cauagauuag caagagugcu                                                   20


<210>  34021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34021
aacauuugug aacagaucga                                                   20


<210>  34022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34022
caaauguuag aaaccuccgu                                                   20


<210>  34023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34023
aucuguucac aaauguuaga                                                   20


<210>  34024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34024
aggauuacug caaucccaau                                                   20


<210>  34025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34025
cccucuaucc cuguccuucc                                                   20


<210>  34026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34026
ccuucacccu cuaucccugu                                                   20


<210>  34027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34027
uaagaccuuu cuccaaagua                                                   20


<210>  34028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34028
ccaaaguaaa uaaaugaugu                                                   20


<210>  34029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34029
aaaaugugcc acaucauuua                                                   20


<210>  34030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34030
aaacucuaga uaugauuauc                                                   20


<210>  34031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34031
uuugacuaaa aacuguucuu                                                   20


<210>  34032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34032
uaauuaaauu accaugagac                                                   20


<210>  34033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34033
auucagcaaa uguaguuugg                                                   20


<210>  34034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34034
gcaaauguag uuuggcuaac                                                   20


<210>  34035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34035
aauuaaauau gguuagccaa                                                   20


<210>  34036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34036
ugcauaucua aaauuaucaa                                                   20


<210>  34037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34037
augugugcuu uucgaaaaag                                                   20


<210>  34038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34038
aaaaaggaau aaauugaaaa                                                   20


<210>  34039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34039
aaaagcacac auggaaagca                                                   20


<210>  34040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34040
uuuuucgaaa agcacacaug                                                   20


<210>  34041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34041
auuuauuccu uuuucgaaaa                                                   20


<210>  34042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34042
ucuauuuuuc aauuuauucc                                                   20


<210>  34043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34043
gggcuuccuc uauuuuucaa                                                   20


<210>  34044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34044
uggauuucag ggcuuccucu                                                   20


<210>  34045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34045
aggaugauug cuguuuggcg                                                   20


<210>  34046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34046
uauuagaaac cauucuucuu                                                   20


<210>  34047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34047
aauacgaacu acgcgccaaa                                                   20


<210>  34048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34048
ucuugaauaa auaguauguu                                                   20


<210>  34049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34049
ugaauaaaua guauguuuaa                                                   20


<210>  34050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34050
agaagaaugg uuucuaauac                                                   20


<210>  34051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34051
uaaacauacu auuuauucaa                                                   20


<210>  34052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34052
cucugcccag cuucuuaaac                                                   20


<210>  34053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34053
cccuccuugu ugauaauaua                                                   20


<210>  34054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34054
uuuauaaauc uugcugaccc                                                   20


<210>  34055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34055
uacuuggauc acaaauuucc                                                   20


<210>  34056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34056
gcaccuuauu uugcuucaua                                                   20


<210>  34057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34057
cuuacucuaa ucuauuacuu                                                   20


<210>  34058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34058
cuuucaaaug acauggagua                                                   20


<210>  34059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34059
aaugacaugg aguaguacug                                                   20


<210>  34060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34060
guacuacucc augucauuug                                                   20


<210>  34061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34061
uucuuucuga gucuagguua                                                   20


<210>  34062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34062
uucugagucu agguuauugu                                                   20


<210>  34063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34063
gagucuaggu uauugugacu                                                   20


<210>  34064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34064
gaguccaguc acaauaaccu                                                   20


<210>  34065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34065
uucugagucc agucacaaua                                                   20


<210>  34066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34066
uuauugcagu gaauaacauu                                                   20


<210>  34067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34067
cugcaauaau gaaauauuuc                                                   20


<210>  34068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34068
caaauguuau ucacugcaau                                                   20


<210>  34069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34069
uaaauuaugc agugaauaac                                                   20


<210>  34070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34070
cugcauaauu uaugaacaau                                                   20


<210>  34071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34071
uaaauguuau ucacugcaua                                                   20


<210>  34072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34072
aggcagagaa cauuaaaugu                                                   20


<210>  34073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34073
cugccuagaa guugagccaa                                                   20


<210>  34074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34074
auuuacaugc uccuagguaa                                                   20


<210>  34075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34075
uacuauggag auuuccauuu                                                   20


<210>  34076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34076
guuagcaaca gcacugcuuu                                                   20


<210>  34077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34077
ccucaucugc ccccuccuaa                                                   20


<210>  34078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34078
uucaccucau cugcccccuc                                                   20


<210>  34079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34079
uuauuacauu gagaggagcc                                                   20


<210>  34080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34080
uuguucaaaa uggauggcuu                                                   20


<210>  34081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34081
aaauggaugg cuuaagaagu                                                   20


<210>  34082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34082
uaagccaucc auuuugaaca                                                   20


<210>  34083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34083
gucuugcagg ccaucccaag                                                   20


<210>  34084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34084
ugcuacaaag guaguguuga                                                   20


<210>  34085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34085
ggugaaacuu uagguacaaa                                                   20


<210>  34086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34086
ccggaacaga gccacauuua                                                   20


<210>  34087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34087
gggguauaga aguuaccauc                                                   20


<210>  34088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34088
auaccccuga aucccagguc                                                   20


<210>  34089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34089
gaugguaacu ucuauacccc                                                   20


<210>  34090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34090
acacugucug auuuugaaaa                                                   20


<210>  34091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34091
aaaucagaca guguagaaga                                                   20


<210>  34092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34092
uuuuuucaaa aucagacagu                                                   20


<210>  34093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34093
guauuuuuau uugcuauuug                                                   20


<210>  34094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34094
cugguauucu guauuuuuau                                                   20


<210>  34095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34095
aauuucacug guauucugua                                                   20


<210>  34096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34096
gauacauuau gaguaauuuu                                                   20


<210>  34097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34097
aaaucaugug ggacauacuu                                                   20


<210>  34098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34098
cuuuaauuac aguugccaga                                                   20


<210>  34099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34099
uuuucccuuu aauuacaguu                                                   20


<210>  34100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34100
uuauguucau auaaugugau                                                   20


<210>  34101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34101
uauaauguga uauagcaggg                                                   20


<210>  34102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34102
uaacaggcca uggaccaaua                                                   20


<210>  34103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34103
ugcugggcag ccugguuccu                                                   20


<210>  34104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34104
caccugagca ccgccuccug                                                   20


<210>  34105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34105
cauaggagug caaacccuau                                                   20


<210>  34106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34106
caauaggguu ugcacuccua                                                   20


<210>  34107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34107
cauaaggagc gcacaaccua                                                   20


<210>  34108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34108
accucagauc aucaggcauu                                                   20


<210>  34109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34109
agacgagacu guuccaccuc                                                   20


<210>  34110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34110
acagggccag gggaugguuu                                                   20


<210>  34111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34111
ugggagacaa uuuuuccaca                                                   20


<210>  34112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34112
ggcaccagag acugguuuca                                                   20


<210>  34113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34113
caguggcacu cauaauagug                                                   20


<210>  34114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34114
cuuuccuagu caccaguuuu                                                   20


<210>  34115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34115
uagucaccag uuuugggaaa                                                   20


<210>  34116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34116
caaaacuggu gacuaggaaa                                                   20


<210>  34117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34117
uucucaugcu gcuccucuag                                                   20


<210>  34118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34118
caugcugcuc cucuagugca                                                   20


<210>  34119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34119
uuaaaaauaa auggagcacu                                                   20


<210>  34120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34120
caugauuuuu uguuauauua                                                   20


<210>  34121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34121
aaauucccau gauuuuuugu                                                   20


<210>  34122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34122
auguuguuuu cuaaauuccc                                                   20


<210>  34123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34123
accaauguga ucauuagcuu                                                   20


<210>  34124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34124
cuaucacuuc caccaaugug                                                   20


<210>  34125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34125
cccccuaaau auuucccuau                                                   20


<210>  34126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34126
uugacaaagu uuauaccuua                                                   20


<210>  34127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34127
cuuuuuuguu guuuuuaaua                                                   20


<210>  34128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34128
ggucagaguu uauaaaaugc                                                   20


<210>  34129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34129
cuguuucuag guuuaugaac                                                   20


<210>  34130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34130
agguuuauga acugacguua                                                   20


<210>  34131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34131
uaaaccuaga aacagagaaa                                                   20


<210>  34132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34132
gaacgccucc acccgagcuu                                                   20


<210>  34133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34133
gaagagcugc ugcaacagcu                                                   20


<210>  34134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34134
gcaaacccug accgcagucg                                                   20


<210>  34135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34135
gccaccagac uccuccuuag                                                   20


<210>  34136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34136
acaauacucc cacuacggcu                                                   20


<210>  34137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34137
aucuuccuug ccaaaacuua                                                   20


<210>  34138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34138
uugccaaaac uuauaauaca                                                   20


<210>  34139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34139
ucuuuauuuu auaaauaggg                                                   20


<210>  34140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34140
gcacuuugga aggaucgcuu                                                   20


<210>  34141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34141
aaagugcuga aauuacaggc                                                   20


<210>  34142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34142
gcccaggagu uugagacaac                                                   20


<210>  34143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34143
cugcagccuc aaccucuugg                                                   20


<210>  34144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34144
cuuauuuuau uuuuaaauuu                                                   20


<210>  34145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34145
uuucucugcc uuggcugccu                                                   20


<210>  34146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34146
cugccuuggc ugccuccugu                                                   20


<210>  34147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34147
cagcaccuaa aaugccacag                                                   20


<210>  34148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34148
uuucucagca ccuaaaaugc                                                   20


<210>  34149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34149
cuacuguuuu cauuucucag                                                   20


<210>  34150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34150
aggauccuca uguuaauuug                                                   20


<210>  34151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34151
ggcaaauuaa caugaggauc                                                   20


<210>  34152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34152
agucgucaga gggaucugag                                                   20


<210>  34153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34153
uuccuggccu gacuugagaa                                                   20


<210>  34154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34154
uggccugacu ugagaaaauc                                                   20


<210>  34155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34155
caagucaggc caggaaggaa                                                   20


<210>  34156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34156
gcugacuccg gccucuccua                                                   20


<210>  34157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34157
cucuaaugug gaggcuguga                                                   20


<210>  34158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34158
gucagauucu cucuaaugug                                                   20


<210>  34159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34159
cacgaggcag caguaagacu                                                   20


<210>  34160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34160
ggcaaacauu uauguucaca                                                   20


<210>  34161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34161
ugcucauggu ucuggcaaac                                                   20


<210>  34162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34162
uguccuuuac acggaagaau                                                   20


<210>  34163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34163
guguaaagga caggaaacaa                                                   20


<210>  34164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34164
uccguguaaa ggacaggaaa                                                   20


<210>  34165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34165
guauggaaug cgugccuuac                                                   20


<210>  34166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34166
auacagaaaa aaauucuucc                                                   20


<210>  34167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34167
acucauuauu uguaaggcac                                                   20


<210>  34168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34168
uuagcgaugg guauuuccac                                                   20


<210>  34169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34169
aauacuuuua auuuggcuuu                                                   20


<210>  34170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34170
uaggucauau cuuuagaacu                                                   20


<210>  34171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34171
aaagauauga ccuaagaaau                                                   20


<210>  34172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34172
aauauauagu ucuaaagaua                                                   20


<210>  34173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34173
uauugaaauu aaaauguuga                                                   20


<210>  34174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34174
auaugaaaau uacauuaaca                                                   20


<210>  34175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34175
acauuuuaau uucaauauga                                                   20


<210>  34176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34176
uguggaaaaa cguucacauu                                                   20


<210>  34177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34177
acaggaaaca cuuaacaucg                                                   20


<210>  34178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34178
cauuuucucu aguuuuaaag                                                   20


<210>  34179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34179
cuaguuuuaa aguugaauca                                                   20


<210>  34180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34180
acuuuaaaac uagagaaaau                                                   20


<210>  34181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34181
aacagcuuga uucaacuuua                                                   20


<210>  34182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34182
cauuucuucu agauuuuauc                                                   20


<210>  34183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34183
ucuagauuuu aucagcuugu                                                   20


<210>  34184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34184
agauuuuauc agcuuguuac                                                   20


<210>  34185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34185
gugauuugca gcuggagggg                                                   20


<210>  34186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34186
ucaugcagcc cuguccuuuc                                                   20


<210>  34187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34187
agaaaacaaa aaggugauua                                                   20


<210>  34188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34188
ugaaaggaca gggcugcaug                                                   20


<210>  34189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34189
gaaaucagag ucuuguguug                                                   20


<210>  34190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34190
gaaauaauca ccuuuuuguu                                                   20


<210>  34191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34191
acacaagacu cugauuucug                                                   20


<210>  34192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34192
uguauuucug uaauguaaug                                                   20


<210>  34193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34193
guaauguaau guaucuugua                                                   20


<210>  34194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34194
uguaauacug uauuggacuc                                                   20


<210>  34195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34195
cagaugagug auuauaugug                                                   20


<210>  34196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34196
cacauauaau cacucaucug                                                   20


<210>  34197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34197
agcaacauuc acacauauaa                                                   20


<210>  34198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34198
ggccugguua ucagauucca                                                   20


<210>  34199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34199
uaucagaauu gcuuugucau                                                   20


<210>  34200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34200
gauaugaaag uaauuuuuaa                                                   20


<210>  34201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34201
aaauuuauga caaagcaauu                                                   20


<210>  34202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34202
aauguucggg gucagcagac                                                   20


<210>  34203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34203
gggucagcag acuuuuuuug                                                   20


<210>  34204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34204
gcucugcccu gugacaggaa                                                   20


<210>  34205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34205
ugucacaggg cagagcugaa                                                   20


<210>  34206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34206
aguagaacuu uacuuacaga                                                   20


<210>  34207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34207
acuggaacau agcuggccag                                                   20


<210>  34208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34208
guaaguaaag uucuacugga                                                   20


<210>  34209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34209
cuaaggcagg uauuggcaaa                                                   20


<210>  34210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34210
caguaaauuu uauuuaguau                                                   20


<210>  34211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34211
ugacuaauac uaaauaaaau                                                   20


<210>  34212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34212
uuuccagccu ggucaacaua                                                   20


<210>  34213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34213
agccugguca acauagugag                                                   20


<210>  34214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34214
guugccuagg cuggagugca                                                   20


<210>  34215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34215
uuuguugggu uauuuuaauu                                                   20


<210>  34216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34216
gccauauuua acuuuguaca                                                   20


<210>  34217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34217
gauauguaca aaguuaaaua                                                   20


<210>  34218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34218
gauaaaacuu aacuuuuauu                                                   20


<210>  34219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34219
uuuccagugu ggguuugcau                                                   20


<210>  34220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34220
aguguggguu ugcauaggaa                                                   20


<210>  34221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34221
uaugcaaacc cacacuggaa                                                   20


<210>  34222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34222
uuuccuaugc aaacccacac                                                   20


<210>  34223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34223
auuuugaaau cuuaaaagac                                                   20


<210>  34224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34224
aaauagaaag ugacagcaau                                                   20


<210>  34225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34225
uguuaagauc ccauuuaaua                                                   20


<210>  34226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34226
agccuucauu gaauuaagua                                                   20


<210>  34227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34227
uugaauuaag uaaacauuuc                                                   20


<210>  34228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34228
augaaggcua gaaugcuauu                                                   20


<210>  34229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34229
uaagagaacu uggaaucuau                                                   20


<210>  34230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34230
cuuaagaaau guuuacuuaa                                                   20


<210>  34231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34231
aaguucucuu aagaaauguu                                                   20


<210>  34232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34232
cuaaaaucuc aaacuugauu                                                   20


<210>  34233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34233
aaacaauguu ucacuaaaau                                                   20


<210>  34234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34234
aggaaaaauu aaugucuaua                                                   20


<210>  34235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34235
uagaauccuu uuggcuucua                                                   20


<210>  34236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34236
ugaauuagga gagauuuugg                                                   20


<210>  34237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34237
agaauauaga cauuaauuuu                                                   20


<210>  34238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34238
uagucgcuuu uuccaguggc                                                   20


<210>  34239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34239
aguggcggug agaacgaaga                                                   20


<210>  34240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34240
caccgccacu ggaaaaagcg                                                   20


<210>  34241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34241
uucucaccgc cacuggaaaa                                                   20


<210>  34242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34242
cauugcucag augaguuuau                                                   20


<210>  34243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34243
ggcugggaca ugggauauau                                                   20


<210>  34244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34244
cccauugaga gcugugucuu                                                   20


<210>  34245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34245
aacucuucug uuauagcugg                                                   20


<210>  34246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34246
guuauagcug gaaaauccuu                                                   20


<210>  34247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34247
agcuauaaca gaagaguuug                                                   20


<210>  34248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34248
cuuaaaaagg auuuuccagc                                                   20


<210>  34249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34249
ucugucuuau aauuugggca                                                   20


<210>  34250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34250
cccuaauccu auauccaaca                                                   20


<210>  34251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34251
gguggcagcc uagcucuugu                                                   20


<210>  34252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34252
ucaaaggcac aagagcuagg                                                   20


<210>  34253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34253
acagagccgu ccccagggua                                                   20


<210>  34254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34254
aaaucagugg uuugcaaaua                                                   20


<210>  34255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34255
gaucuuaaca aaagccaucu                                                   20


<210>  34256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34256
ccuuuuuggc auuuuauuug                                                   20


<210>  34257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34257
caagguaaag aacuuauuuu                                                   20


<210>  34258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34258
uuaccuugag aaaucaaaua                                                   20


<210>  34259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34259
uauuauuuag uagauaggcc                                                   20


<210>  34260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34260
auguagauuu uggguuuccu                                                   20


<210>  34261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34261
uuugcucauu uuuucacucu                                                   20


<210>  34262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34262
cucuuaaucu cacaucauug                                                   20


<210>  34263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34263
auaaacuuac aaugauguga                                                   20


<210>  34264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34264
gacuuuuucu uugaagagca                                                   20


<210>  34265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34265
uugaagagca gaaauuagaa                                                   20


<210>  34266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34266
aagaaaaagu cagaaguaug                                                   20


<210>  34267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34267
gcucuucaaa gaaaaaguca                                                   20


<210>  34268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34268
aauuucugcu cuucaaagaa                                                   20


<210>  34269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34269
caauaauuau uuugauagug                                                   20


<210>  34270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34270
guuuuaaauc auauuaagac                                                   20


<210>  34271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34271
uuuguucuca uuaauguaau                                                   20


<210>  34272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34272
cauuaaugua auucugaaga                                                   20


<210>  34273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34273
gaagaugaac aauaaaaugu                                                   20


<210>  34274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34274
gaauuacauu aaugagaaca                                                   20


<210>  34275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34275
ucuucagaau uacauuaaug                                                   20


<210>  34276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34276
aaaaauacau uuuauuguuc                                                   20


<210>  34277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34277
aaugaaauau uauuucaucc                                                   20


<210>  34278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34278
uuugaaaguu cuaaaaauac                                                   20


<210>  34279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34279
uccuuccaga ucauauaaug                                                   20


<210>  34280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34280
agaucauaua augcuuaagu                                                   20


<210>  34281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34281
gauuguuaau cauaaagucu                                                   20


<210>  34282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34282
agacuuuaug auuaacaauc                                                   20


<210>  34283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34283
uuuuauuauc uuuuaauuuu                                                   20


<210>  34284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34284
ggugugucau uggagcuaug                                                   20


<210>  34285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34285
ugucauagcu ccaaugacac                                                   20


<210>  34286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34286
aaggccaaua gcauuggauc                                                   20


<210>  34287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34287
caaacuauac cacaaaacau                                                   20


<210>  34288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34288
auauagguuu auugacuuua                                                   20


<210>  34289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34289
aaacauaaca ucucuacauu                                                   20


<210>  34290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34290
uuguguuuaa uacuguggag                                                   20


<210>  34291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34291
uaugaguuuc auuuuagagu                                                   20


<210>  34292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34292
uuuuagagug cauuuacuua                                                   20


<210>  34293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34293
aaauuaagua aaugcacucu                                                   20


<210>  34294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34294
uuuuaguuug cuaaaaauaa                                                   20


<210>  34295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34295
ccuaagagca cuuugccuag                                                   20


<210>  34296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34296
ucuccuaaga gcacuuugcc                                                   20


<210>  34297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34297
ucuucuccua agagcacuuu                                                   20


<210>  34298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34298
gagucauccu ccaaggcuuc                                                   20


<210>  34299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34299
cacuaguuag ccgcuggugu                                                   20


<210>  34300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34300
cugucugccu uccaccccuu                                                   20


<210>  34301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34301
accccuugcc cuuccugcuc                                                   20


<210>  34302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34302
ugcucguccc ccugcaccug                                                   20


<210>  34303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34303
ggcuucuuuu auaauacuua                                                   20


<210>  34304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34304
uuuauaauac uuacucugaa                                                   20


<210>  34305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34305
gaguaaguau uauaaaagaa                                                   20


<210>  34306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34306
augguuuagg cuguuuuaaa                                                   20


<210>  34307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34307
accugccauc cccuacucac                                                   20


<210>  34308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34308
caacccccag cauaacccau                                                   20


<210>  34309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34309
ucccauuucc caacccccag                                                   20


<210>  34310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34310
ucccauaauu uuucauccca                                                   20


<210>  34311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34311
aguuaaacua uccauaggca                                                   20


<210>  34312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34312
uucaaguuaa acuauccaua                                                   20


<210>  34313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34313
uuuuugagau agagucucac                                                   20


<210>  34314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34314
ggguuccagc gauucuccug                                                   20


<210>  34315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34315
agcgauucuc cugccucagc                                                   20


<210>  34316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34316
ccugccucag ccucccaagu                                                   20


<210>  34317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34317
agaccagccu gaccaacaug                                                   20


<210>  34318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34318
uuagauaagu aucuguaacu                                                   20


<210>  34319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34319
cuguguacuu uauaaaagau                                                   20


<210>  34320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34320
guuaauccuc aucuuuuaua                                                   20


<210>  34321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34321
uuuagauagg auuauacaac                                                   20


<210>  34322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34322
guuauagcua aaauauucuu                                                   20


<210>  34323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34323
ucucuaaaua uuuaagucuu                                                   20


<210>  34324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34324
gauuuuccuc ucuaaauauu                                                   20


<210>  34325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34325
aguaguaauu auuuauuuac                                                   20


<210>  34326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34326
ugucgaccuu uuugccauaa                                                   20


<210>  34327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34327
aaauuaccau uuaaaaacaa                                                   20


<210>  34328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34328
uaguugacuu ucuaaauuac                                                   20


<210>  34329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34329
aggagaauag gacuggaguc                                                   20


<210>  34330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34330
ccuggaagau aaaccuguaa                                                   20


<210>  34331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34331
agaucucgac uccaguccua                                                   20


<210>  34332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34332
aagccacauu caagaucucg                                                   20


<210>  34333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34333
uccaagccac auucaagauc                                                   20


<210>  34334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34334
gaccacugcu ugcuuagagg                                                   20


<210>  34335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34335
uaaccgacua cuccaagccu                                                   20


<210>  34336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34336
aguucuuaac cgacuacucc                                                   20


<210>  34337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34337
guuuuugcag ugaaacagca                                                   20


<210>  34338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34338
cugcaaaaac cgaaguucaa                                                   20


<210>  34339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34339
caaaugcugu uucacugcaa                                                   20


<210>  34340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34340
gauaagccuu auuuuauaag                                                   20


<210>  34341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34341
agcaucucuc acacugccuc                                                   20


<210>  34342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34342
gcaucuucag gaugcugugc                                                   20


<210>  34343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34343
ggaugcugug cagcugaaac                                                   20


<210>  34344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34344
gcugcacagc auccugaaga                                                   20


<210>  34345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34345
accguuauca aauguuucag                                                   20


<210>  34346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34346
uuauuuugca agccugugau                                                   20


<210>  34347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34347
cuauugaaug uuuucucucg                                                   20


<210>  34348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34348
auagggaauc acaggcuugc                                                   20


<210>  34349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34349
cucgccauuu gacaaaugag                                                   20


<210>  34350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34350
cugucuucag ccucagugaa                                                   20


<210>  34351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34351
gccucaguga aggaugagau                                                   20


<210>  34352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34352
cugaggcuga agacagagaa                                                   20


<210>  34353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34353
ucagggguuu ccacuccagg                                                   20


<210>  34354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34354
gggguuucca cuccaggguc                                                   20


<210>  34355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34355
acuccagggu cagcagguca                                                   20


<210>  34356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34356
gugaugaugu caugaccugc                                                   20


<210>  34357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34357
gguccauggc agggucagau                                                   20


<210>  34358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34358
gugguggucu gggagcuguc                                                   20


<210>  34359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34359
gcuguuaccc cuucagacag                                                   20


<210>  34360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34360
gacaguucug aaauuguaag                                                   20


<210>  34361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34361
gaaauuguaa gugggcagag                                                   20


<210>  34362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34362
gaacugucug aagggguaac                                                   20


<210>  34363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34363
agaccagccu ggccaacaug                                                   20


<210>  34364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34364
ccauguuggc caggcugguc                                                   20


<210>  34365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34365
ccugccucag ccucccuaac                                                   20


<210>  34366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34366
aaaaaaauaa aaaaauaaag                                                   20


<210>  34367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34367
cagcccacug caacuucugc                                                   20


<210>  34368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34368
gccucccagg cucgagcgau                                                   20


<210>  34369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34369
cccgccucag ccuccugagu                                                   20


<210>  34370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34370
guagagacag gguuucacca                                                   20


<210>  34371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34371
ccauguuggc caggcugguc                                                   20


<210>  34372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34372
ucccuggaga ccuagaccug                                                   20


<210>  34373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34373
cuggagaccu agaccugaac                                                   20


<210>  34374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34374
ggucuagguc uccagggaag                                                   20


<210>  34375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34375
cuuguuaucu aauaccccua                                                   20


<210>  34376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34376
cugaaggaaa caacuuagug                                                   20


<210>  34377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34377
gugaagguau cagaugaggu                                                   20


<210>  34378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34378
uucagugaag guaucagaug                                                   20


<210>  34379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34379
acacaaaaga cacuaaguug                                                   20


<210>  34380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34380
aauuuuuuac cucaguguuc                                                   20


<210>  34381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34381
uauaaucaac uauuccaauu                                                   20


<210>  34382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34382
uuaagaccac agaucuguuu                                                   20


<210>  34383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34383
uaaaauaaug cacaguauua                                                   20


<210>  34384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34384
aaaaacuuuu acaacauuuc                                                   20


<210>  34385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34385
cauuugauag cggcauaggu                                                   20


<210>  34386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34386
caucucuaag uuaguggaca                                                   20


<210>  34387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34387
guuuuaaaaa cugugguuaa                                                   20


<210>  34388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34388
uaaccauuuu uugcguauac                                                   20


<210>  34389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34389
cugguauuaa auacauuuaa                                                   20


<210>  34390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34390
augacauuau uuaaauguau                                                   20


<210>  34391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34391
guguuacaug aucaaaaggu                                                   20


<210>  34392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34392
cauugaacuc uauuccuccu                                                   20


<210>  34393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34393
augggaacag agcuucagug                                                   20


<210>  34394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34394
uccuuucccg ccaagucccu                                                   20


<210>  34395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34395
cgccaagucc cuggcaacca                                                   20


<210>  34396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34396
ucuuucuguc uucugaauuu                                                   20


<210>  34397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34397
uucugucuuc ugaauuugac                                                   20


<210>  34398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34398
gucuucugaa uuugacuacu                                                   20


<210>  34399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34399
gaauuugacu acuuuggguu                                                   20


<210>  34400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34400
gaagacagaa agaagaaucg                                                   20


<210>  34401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34401
cauauacuuu aggagucaca                                                   20


<210>  34402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34402
aacauaggcu acaacaugca                                                   20


<210>  34403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34403
uaauguuuca ggccaaauac                                                   20


<210>  34404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34404
ggccaaauac uauuccauug                                                   20


<210>  34405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34405
auuguaugga uaggccacau                                                   20


<210>  34406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34406
auuccucugu ccauggacac                                                   20


<210>  34407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34407
ucuguccaug gacacuugua                                                   20


<210>  34408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34408
uguuuuagcc auugugaauc                                                   20


<210>  34409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34409
caauggcuaa aacaugaagc                                                   20


<210>  34410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34410
uaacagcaug auucacaaug                                                   20


<210>  34411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34411
auuuuuuugg cuaaauaccc                                                   20


<210>  34412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34412
ggguauuuag ccaaaaaaau                                                   20


<210>  34413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34413
aauuuuaauu uaaaacauuc                                                   20


<210>  34414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34414
uaucauugag uguuuuacuu                                                   20


<210>  34415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34415
guuuuuuuag guaaauuaca                                                   20


<210>  34416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34416
aguggacaug aaacaucuug                                                   20


<210>  34417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34417
uguccacuug aaauguccug                                                   20


<210>  34418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34418
acaucacaag auguuucaug                                                   20


<210>  34419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34419
uauguuuagc caucagcuug                                                   20


<210>  34420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34420
acaaaaaccu aacaauauaa                                                   20


<210>  34421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34421
aacuugcugu aaaauuuguu                                                   20


<210>  34422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34422
caaacaaauu uuacagcaag                                                   20


<210>  34423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34423
uuuucauauu aaaaagaaau                                                   20


<210>  34424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34424
uauuaaaaag aaauguccac                                                   20


<210>  34425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34425
uuuuaauaug aaaaagaaaa                                                   20


<210>  34426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34426
aauguggaca uuucuuuuua                                                   20


<210>  34427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34427
uaauguagug ggaaugagug                                                   20


<210>  34428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34428
cacuacauua ugaaaagcuc                                                   20


<210>  34429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34429
augcgugcau uucugugccu                                                   20


<210>  34430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34430
gugccuugaa auaaaugaca                                                   20


<210>  34431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34431
aggcacagaa augcacgcau                                                   20


<210>  34432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34432
guguguaaaa ugugcucuuu                                                   20


<210>  34433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34433
ucauugcacu uccauguugg                                                   20


<210>  34434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34434
auguuggagg gcuugucucu                                                   20


<210>  34435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34435
aaauucucac agccccccuu                                                   20


<210>  34436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34436
cacagccccc cuugaaccgu                                                   20


<210>  34437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34437
aggggggcug ugagaauuuu                                                   20


<210>  34438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34438
uccuggggcu guccaaucug                                                   20


<210>  34439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34439
ucaucuucau ccuggggcug                                                   20


<210>  34440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34440
uccugaugaa gccucggagg                                                   20


<210>  34441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34441
ugaugaagcc ucggaggccu                                                   20


<210>  34442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34442
ucaggaagaa uaccuguggc                                                   20


<210>  34443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34443
ggaacucuuc cauggguaug                                                   20


<210>  34444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34444
ugaaggccuc cgaggcuuca                                                   20


<210>  34445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34445
auggguaugu ggacuacagg                                                   20


<210>  34446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34446
gaccuggaca ucuuaauuau                                                   20


<210>  34447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34447
aagaagaagu ccuuugauac                                                   20


<210>  34448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34448
uggaagcaaa gauauaauua                                                   20


<210>  34449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34449
ucuuggaagc aaagauauaa                                                   20


<210>  34450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34450
gaguucugaa uagcugauga                                                   20


<210>  34451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34451
gaauagcuga ugaaaaugac                                                   20


<210>  34452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34452
gaacucagaa aacaguauca                                                   20


<210>  34453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34453
ucagcuauuc agaacucaga                                                   20


<210>  34454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34454
ucaauugguc auuuucauca                                                   20


<210>  34455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34455
ugaucuaaau cuuauacuuu                                                   20


<210>  34456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34456
acuuaaaaua caauuauaca                                                   20


<210>  34457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34457
cuguuuuuaa agcccuucaa                                                   20


<210>  34458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34458
acaggcacau uuauugaaaa                                                   20


<210>  34459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34459
auaaaugugc cuguugaagg                                                   20


<210>  34460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34460
gacagcagug uugauaaauu                                                   20


<210>  34461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34461
ucucucaaca caaauuuauc                                                   20


<210>  34462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34462
guagcuucau cucucaacac                                                   20


<210>  34463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34463
ugaucacccg guucaguagc                                                   20


<210>  34464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34464
gagcuugugu gaggauuuaa                                                   20


<210>  34465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34465
caucccuggg ccuuuaaauu                                                   20


<210>  34466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34466
ccuuuaaaua ccagcucuuc                                                   20


<210>  34467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34467
caggccuguu guuuucugcc                                                   20


<210>  34468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34468
gccuuuccag guacuaccca                                                   20


<210>  34469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34469
agguacuacc cacagccuug                                                   20


<210>  34470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34470
caaggcugug gguaguaccu                                                   20


<210>  34471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34471
gccuccuuug agagugugcc                                                   20


<210>  34472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34472
guacugaaug uuuccuuguc                                                   20


<210>  34473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34473
guacagaaua gauuugucug                                                   20


<210>  34474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34474
uugucugauu ucuuggauca                                                   20


<210>  34475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34475
uggaucauuc auuugauggu                                                   20


<210>  34476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34476
uuugaugguu gcguauggcc                                                   20


<210>  34477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34477
uguuuugguu cuacugaacu                                                   20


<210>  34478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34478
acugaacugu ucuaaaaguc                                                   20


<210>  34479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34479
guagaaccaa aacaagaaac                                                   20


<210>  34480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34480
aaaagucucu cuucauauua                                                   20


<210>  34481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34481
uauuaucuuu uuacauguaa                                                   20


<210>  34482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34482
cuuuuaauuc cucaaggaca                                                   20


<210>  34483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34483
ucaaggacaa ggaauagcgu                                                   20


<210>  34484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34484
uuguccuuga ggaauuaaaa                                                   20


<210>  34485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34485
caguucgucc caucaaucag                                                   20


<210>  34486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34486
ucccaucaau cagaauuaua                                                   20


<210>  34487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34487
gauugauggg acgaacugug                                                   20


<210>  34488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34488
ucuuagauuu gggcuucccc                                                   20


<210>  34489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34489
ccaggcuguu gccuuucccc                                                   20


<210>  34490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34490
ccaaguagcu ucugcuuguc                                                   20


<210>  34491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34491
gcuuguccug uagaagaccu                                                   20


<210>  34492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34492
acaggacaag cagaagcuac                                                   20


<210>  34493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34493
ugcuuugcuu cugcagcagc                                                   20


<210>  34494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34494
gcagcagccg uuccugaaug                                                   20


<210>  34495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34495
ugaaugccua gugucaacug                                                   20


<210>  34496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34496
ggaacggcug cugcagaagc                                                   20


<210>  34497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34497
uaccacgccc acccucccug                                                   20


<210>  34498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34498
gcuuggccau ggucucugug                                                   20


<210>  34499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34499
agagcagcac uuaagccagg                                                   20


<210>  34500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34500
acagauaguu ccagagcagc                                                   20


<210>  34501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34501
uucaacagau aguuccagag                                                   20


<210>  34502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34502
ugcauuaguu cauucaacag                                                   20


<210>  34503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34503
agccuugccg caucaaaggu                                                   20


<210>  34504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34504
uuuuugcuaa cagggggaaa                                                   20


<210>  34505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34505
cccuguuagc aaaaacgaag                                                   20


<210>  34506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34506
acugugcaca uccccuuuug                                                   20


<210>  34507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34507
uucaacugug cacauccccu                                                   20


<210>  34508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34508
gaggucagcu ugguggccug                                                   20


<210>  34509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34509
ucugcugcac gcaaggcaaa                                                   20


<210>  34510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34510
acuuccucug cugcacgcaa                                                   20


<210>  34511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34511
cuagccgagg ggagggagga                                                   20


<210>  34512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34512
ucccuccccu cggcuaguga                                                   20


<210>  34513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34513
uuugaaaaca aucuguuguu                                                   20


<210>  34514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34514
aaugaacaaa accagaccca                                                   20


<210>  34515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34515
gccucaaaca acagauuguu                                                   20


<210>  34516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34516
uggcagugcu gguuccggac                                                   20


<210>  34517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34517
ggacagggau gugaggguca                                                   20


<210>  34518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34518
cgcugacccu cacaucccug                                                   20


<210>  34519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34519
ggguggaggg ccacagcugc                                                   20


<210>  34520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34520
ucagcaaacu cuauaaaguu                                                   20


<210>  34521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34521
gcaaacucua uaaaguuccu                                                   20


<210>  34522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34522
ucuugacacc acggaauacc                                                   20


<210>  34523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34523
guggugucaa gaggaacuuu                                                   20


<210>  34524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34524
caucuuauuu ucucagauuu                                                   20


<210>  34525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34525
cagauuuaau cauuauugua                                                   20


<210>  34526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34526
guauugacua uuuuaguuuu                                                   20


<210>  34527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34527
uuugggauau uugaccugcg                                                   20


<210>  34528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34528
gaaaacacau gaauagugaa                                                   20


<210>  34529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34529
gaagagcuac aacgcagguc                                                   20


<210>  34530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34530
uguguuuucu gaagagcuac                                                   20


<210>  34531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34531
cuauucaugu guuuucugaa                                                   20


<210>  34532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34532
uuguuucaug gguucccuuu                                                   20


<210>  34533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34533
uggguucccu uuagaugaaa                                                   20


<210>  34534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34534
cuuuagauga aacccauaga                                                   20


<210>  34535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34535
ucuaaaggga acccaugaaa                                                   20


<210>  34536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34536
ccucuauggg uuucaucuaa                                                   20


<210>  34537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34537
acuuuucucc ucuauggguu                                                   20


<210>  34538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34538
cacucagggu gagugggaac                                                   20


<210>  34539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34539
cacucacccu gagugugaau                                                   20


<210>  34540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34540
cguucucucu uuuucuuugg                                                   20


<210>  34541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34541
cucuuuuucu uugggugaga                                                   20


<210>  34542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34542
uugggugaga ggguacacuu                                                   20


<210>  34543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34543
aaaacacaag uguacccucu                                                   20


<210>  34544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34544
aaucuuuuuu aaguggaauc                                                   20


<210>  34545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34545
acuuaaaaaa gauuagaaaa                                                   20


<210>  34546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34546
agauuccacu uaaaaaagau                                                   20


<210>  34547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34547
agguugucag auaauaaauc                                                   20


<210>  34548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34548
ggauuauaau ucuagguugu                                                   20


<210>  34549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34549
ucauauugcc aauauguccu                                                   20


<210>  34550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34550
uaaauccuga aacuuuuuuu                                                   20


<210>  34551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34551
ggauuuaaga auuagagauu                                                   20


<210>  34552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34552
cuauaauaac ccuaagugau                                                   20


<210>  34553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34553
gaauuuggau cuucucuuca                                                   20


<210>  34554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34554
gaaaugacuu cacuauaaua                                                   20


<210>  34555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34555
cuucacaccu cuuuuucucu                                                   20


<210>  34556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34556
caccucuuuu ucucuuuccu                                                   20


<210>  34557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34557
cuuuccugag aauuaagcuu                                                   20


<210>  34558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34558
ugagaauuaa gcuuuuguuu                                                   20


<210>  34559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34559
caggaaagag aaaaagaggu                                                   20


<210>  34560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34560
aguuagaaag uugauaguag                                                   20


<210>  34561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34561
aacucgaaac aaaagcuuaa                                                   20


<210>  34562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34562
cuacuaucaa cuuucuaacu                                                   20


<210>  34563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34563
auggcugagc aauuuaucuc                                                   20


<210>  34564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34564
ucuguggaga uaaauugcuc                                                   20


<210>  34565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34565
agaugucuga gacauacugu                                                   20


<210>  34566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34566
aggagccacu gccauucucu                                                   20


<210>  34567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34567
cugugggacc cucaucugcu                                                   20


<210>  34568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34568
acgugggaga uuggaugggc                                                   20


<210>  34569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34569
aauggugccc auccaaucuc                                                   20


<210>  34570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34570
gcuguguuuu uucuaguuau                                                   20


<210>  34571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34571
aguuaugcuu acuaagguuu                                                   20


<210>  34572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34572
ucugguuagg aaauacauuu                                                   20


<210>  34573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34573
gguuaggaaa uacauuuucu                                                   20


<210>  34574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34574
uaaccagaag aacaagcaac                                                   20


<210>  34575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34575
uuggcggauu gcauuccuuu                                                   20


<210>  34576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34576
uuugcugcgg aaaacacuga                                                   20


<210>  34577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34577
gcagcaaagg aaugcaaucc                                                   20


<210>  34578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34578
guguuuuccg cagcaaagga                                                   20


<210>  34579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34579
guuacuugca aguuagcuug                                                   20


<210>  34580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34580
guggaaccau uucuucacuu                                                   20


<210>  34581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34581
acagaagauu augcucaccc                                                   20


<210>  34582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34582
ucacuuagug gacauuuuau                                                   20


<210>  34583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34583
cuuaguggac auuuuaucau                                                   20


<210>  34584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34584
uauuaagcuc caauuuuaau                                                   20


<210>  34585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34585
augcacucua aagcuguaac                                                   20


<210>  34586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34586
aaagcugaga gauggauaca                                                   20


<210>  34587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34587
uucuaaagcu gagagaugga                                                   20


<210>  34588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34588
uaaacuucag uuuaaguucu                                                   20


<210>  34589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34589
guuuaaguuc uaauucucag                                                   20


<210>  34590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34590
aauucucaga auauuuguuu                                                   20


<210>  34591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34591
cagaauauuu guuugaaaua                                                   20


<210>  34592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34592
gagaauuaga acuuaaacug                                                   20


<210>  34593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34593
aacaaauauu cugagaauua                                                   20


<210>  34594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34594
uaaaggauau auuuagaaau                                                   20


<210>  34595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34595
aaauauaucc uuuaggaaga                                                   20


<210>  34596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34596
acagacuuua cacuuaauga                                                   20


<210>  34597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34597
accuuggccu cccaaagugg                                                   20


<210>  34598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34598
agacuauggg caacauaguu                                                   20


<210>  34599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34599
guagggacag ggucaacuau                                                   20


<210>  34600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34600
cgaguagcug agacuacagg                                                   20


<210>  34601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34601
acugauuauu auuacuauua                                                   20


<210>  34602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34602
guauaaagug gaauaggcuc                                                   20


<210>  34603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34603
acuuuauaca gaaacagagg                                                   20


<210>  34604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34604
uuaagugaua gcauguugaa                                                   20


<210>  34605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34605
acaugcuauc acuuaaagaa                                                   20


<210>  34606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34606
auaccaacug gcucauaagu                                                   20


<210>  34607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34607
cucuaguuuc cagguuuuca                                                   20


<210>  34608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34608
agguuuucag ucaguugugu                                                   20


<210>  34609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34609
gucaguugug ucuuuuuuga                                                   20


<210>  34610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34610
gcucaaaaaa gacacaacug                                                   20


<210>  34611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34611
uucugcucaa aaaagacaca                                                   20


<210>  34612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34612
guucucucgu gcuguggagu                                                   20


<210>  34613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34613
cucgugcugu ggaguacaua                                                   20


<210>  34614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34614
uaccccuggg ucugagauuu                                                   20


<210>  34615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34615
aaauaaaucu cagacccagg                                                   20


<210>  34616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34616
caaacauuga ucaguuacag                                                   20


<210>  34617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34617
acucucaaac agcaacuuca                                                   20


<210>  34618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34618
gcuuauguca ugguuucaac                                                   20


<210>  34619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34619
auuucugcuu augucauggu                                                   20


<210>  34620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34620
uuccauuucu gcuuauguca                                                   20


<210>  34621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34621
uccuuccauu ucugcuuaug                                                   20


<210>  34622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34622
uucuuccuuc cauuucugcu                                                   20


<210>  34623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34623
cauaacuggu ucuuucuucc                                                   20


<210>  34624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34624
uaaucaaugu ucuugagagg                                                   20


<210>  34625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34625
ugagaggugu gggaaaaaug                                                   20


<210>  34626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34626
cacaccucuc aagaacauug                                                   20


<210>  34627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34627
ggguuuaacu gcaaccagga                                                   20


<210>  34628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34628
acacacaaug uucuggguuu                                                   20


<210>  34629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34629
caaaccguca agacgcgggu                                                   20


<210>  34630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34630
agaacugugu caugagucuc                                                   20


<210>  34631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34631
ggaacacaag guccaaggca                                                   20


<210>  34632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34632
ucagagucag cacaucgaug                                                   20


<210>  34633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34633
uauuggcugg ugaggacaga                                                   20


<210>  34634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34634
ggaaacccuu gcagagauug                                                   20


<210>  34635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34635
agaagcucug uccucaccag                                                   20


<210>  34636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34636
gguaagugag ucacauccau                                                   20


<210>  34637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34637
ugaacuaagc ucaauugaaa                                                   20


<210>  34638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34638
ugaaaucuaa uggaugugac                                                   20


<210>  34639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34639
auugagcuua guucaugaaa                                                   20


<210>  34640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34640
gggaucacuu gaugcaagga                                                   20


<210>  34641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34641
uugcaucaag ugaucccaga                                                   20


<210>  34642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34642
gauggacagg guacuugaua                                                   20


<210>  34643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34643
ccucccagug gcuuuuugcu                                                   20


<210>  34644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34644
gcaaaaagcc acugggagga                                                   20


<210>  34645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34645
aagcauaggg caaaguucag                                                   20


<210>  34646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34646
agccugggcg acagagcaag                                                   20


<210>  34647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34647
gugagcuaug auugugcuac                                                   20


<210>  34648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34648
aagcuucagu gagcuaugau                                                   20


<210>  34649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34649
ccuagcuaau cgggaggcug                                                   20


<210>  34650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34650
acaaaaaaua uuagccagug                                                   20


<210>  34651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34651
aggccaggca caguggcuca                                                   20


<210>  34652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34652
acuuauauuu uaaaauucua                                                   20


<210>  34653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34653
ggauaguggg aauaaaagag                                                   20


<210>  34654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34654
cacuauccag aauacuuaaa                                                   20


<210>  34655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34655
aagcucuuuu auucccacua                                                   20


<210>  34656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34656
ucuuugucuu aaacuuuuaa                                                   20


<210>  34657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34657
gcuuguuuaa aaagaauaua                                                   20


<210>  34658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34658
uuuuaaacaa gcagaauuaa                                                   20


<210>  34659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34659
uuauacugaa ccuagguaag                                                   20


<210>  34660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34660
guauaaugaa gaguauauuc                                                   20


<210>  34661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34661
gccuggcaac agagugagac                                                   20


<210>  34662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34662
uuuucuaaga guaguuuugg                                                   20


<210>  34663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34663
aagaguaguu uuggcuggag                                                   20


<210>  34664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34664
ccagccaaaa cuacucuuag                                                   20


<210>  34665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34665
uucaguacuu ucuuuuagaa                                                   20


<210>  34666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34666
guacuuucuu uuagaaggga                                                   20


<210>  34667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34667
uuuagaaggg aaauuuuccu                                                   20


<210>  34668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34668
aaaagaaagu acugaaagaa                                                   20


<210>  34669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34669
cuucuaaaag aaaguacuga                                                   20


<210>  34670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34670
uuuauaauuu aggguuuguu                                                   20


<210>  34671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34671
aagccaccuu uuauagagcc                                                   20


<210>  34672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34672
uuuaauccuu agaauguuua                                                   20


<210>  34673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34673
aaggauuaaa ugaaauaacc                                                   20


<210>  34674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34674
cggcuccacc cacagauagg                                                   20


<210>  34675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34675
guggcuugag ccaauuuuau                                                   20


<210>  34676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34676
aaagacucug uaagugcccu                                                   20


<210>  34677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34677
aaauaaauac uauuucaaaa                                                   20


<210>  34678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34678
ucaaaauaaa uacuauuuca                                                   20


<210>  34679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34679
uuuucuucaa aauaaauacu                                                   20


<210>  34680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34680
agacucaaua agacaguacu                                                   20


<210>  34681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34681
ucucacaauu ccagacucaa                                                   20


<210>  34682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34682
agggcaccug gaugagccug                                                   20


<210>  34683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34683
uuguuaaaug ugcucuuuug                                                   20


<210>  34684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34684
gcuuuugccu ccaaaaagcu                                                   20


<210>  34685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34685
agaaggugaa agugaggcuu                                                   20


<210>  34686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34686
ugaagguaaa acagcaucuc                                                   20


<210>  34687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34687
ccuucuugaa gguaaaacag                                                   20


<210>  34688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34688
uuguggaauu ucucuaaaug                                                   20


<210>  34689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34689
acaaggaaag ccucacuuuc                                                   20


<210>  34690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34690
cuaaaugcau ucgucauguu                                                   20


<210>  34691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34691
ucauguuuua gauguuuauu                                                   20


<210>  34692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34692
caguuuauau caugaaaguu                                                   20


<210>  34693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34693
ugauauaaac ugugaaauaa                                                   20


<210>  34694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34694
uucucacuag cuuuccaaaa                                                   20


<210>  34695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34695
cacuagcuuu ccaaaauauc                                                   20


<210>  34696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34696
aaaauaucuu accuaaaauu                                                   20


<210>  34697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34697
cucuaaagcu uuuaaaacug                                                   20


<210>  34698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34698
ugcaguuuua aaagcuuuag                                                   20


<210>  34699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34699
ucuccaagca aauggaugac                                                   20


<210>  34700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34700
uuuuuugguu gaaguacuaa                                                   20


<210>  34701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34701
accaaaaaag gaaaagagau                                                   20


<210>  34702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34702
cguaucuuuu aguacuucaa                                                   20


<210>  34703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34703
auucucguau cuuuuaguac                                                   20


<210>  34704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34704
cucucuuucc auucucguau                                                   20


<210>  34705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34705
ucccucucuu uccauucucg                                                   20


<210>  34706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34706
aaggauguag agcaguauuc                                                   20


<210>  34707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34707
ugaaucugag cucauuucag                                                   20


<210>  34708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34708
ggaauacugc ucuacauccu                                                   20


<210>  34709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34709
gccauucuau ucuuaaacua                                                   20


<210>  34710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34710
auucuuaaac uauaaugaaa                                                   20


<210>  34711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34711
uaaacuauaa ugaaaaaaaa                                                   20


<210>  34712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34712
uuauaguuua agaauagaau                                                   20


<210>  34713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34713
uuguaaaaau uuuggacuau                                                   20


<210>  34714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34714
cuauagucca aaauuuuuac                                                   20


<210>  34715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34715
uaguacuauu cucuauaguc                                                   20


<210>  34716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34716
ucuuaguacu auucucuaua                                                   20


<210>  34717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34717
auucugcugc caccuggagg                                                   20


<210>  34718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34718
gcugccaccu ggagguaauc                                                   20


<210>  34719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34719
uguucaaaau caggucaaaa                                                   20


<210>  34720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34720
aaaucagguc aaaauuacau                                                   20


<210>  34721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34721
acuuaauauu uuauuagcau                                                   20


<210>  34722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34722
uguuaugaaa caguaauuuu                                                   20


<210>  34723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34723
uaacaggaaa augcuaauaa                                                   20


<210>  34724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34724
uuuucugaga auuccuggaa                                                   20


<210>  34725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34725
gagaauuccu ggaaguugag                                                   20


<210>  34726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34726
cagaaaaaga aaacuauaca                                                   20


<210>  34727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34727
uggaaguuga guuaccaggc                                                   20


<210>  34728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34728
aggaauucuc agaaaaagaa                                                   20


<210>  34729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34729
aagccgggcc ugguaacuca                                                   20


<210>  34730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34730
agcgauucuc cugccucagc                                                   20


<210>  34731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34731
ccugccucag ccucccgagu                                                   20


<210>  34732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34732
cgauauuggc caggcugguc                                                   20


<210>  34733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34733
agaccagccu ggccaauauc                                                   20


<210>  34734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34734
gaccccguga uccaccugca                                                   20


<210>  34735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34735
aauagcuuua uggagguuau                                                   20


<210>  34736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34736
ugaaauguac ucacuuugag                                                   20


<210>  34737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34737
agaaauguaa auuauaaccu                                                   20


<210>  34738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34738
gucaccccaa auguauccuu                                                   20


<210>  34739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34739
ugccccaacu ccuaggcagc                                                   20


<210>  34740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34740
gucccuuaag auuuguguuu                                                   20


<210>  34741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34741
ccaggcgcuc augccuguaa                                                   20


<210>  34742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34742
agaccagccu ggccaacaug                                                   20


<210>  34743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34743
ccauguuggc caggcugguc                                                   20


<210>  34744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34744
ccugccucag ccucccgagu                                                   20


<210>  34745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34745
agugauucuc cugccucagc                                                   20


<210>  34746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34746
aaccugggca acagagagag                                                   20


<210>  34747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34747
ggacauuuua uaguacuggg                                                   20


<210>  34748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34748
uuuacuuaau ugugagauug                                                   20


<210>  34749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34749
uguuguagca uguaucagua                                                   20


<210>  34750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34750
uuuuuauugg cgaaaguauu                                                   20


<210>  34751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34751
ccaauaaaaa ugaacaaacu                                                   20


<210>  34752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34752
auuauaugaa uaauaccaua                                                   20


<210>  34753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34753
uauaauagaa uacuuucgcc                                                   20


<210>  34754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34754
uguuuuggcu aauuuaugaa                                                   20


<210>  34755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34755
uaaauuagcc aaaacaugaa                                                   20


<210>  34756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34756
caguaccaua auucauaaau                                                   20


<210>  34757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34757
uuucucuuga guagaucacc                                                   20


<210>  34758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34758
cuugaguaga ucaccuagaa                                                   20


<210>  34759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34759
aggugaucua cucaagagaa                                                   20


<210>  34760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34760
caguaaguac caaaauuauu                                                   20


<210>  34761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34761
aaaacauacc auuguuccuu                                                   20


<210>  34762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34762
uuccuuccuu ccuuccuucc                                                   20


<210>  34763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34763
uuccuuccuu ccuuccuucc                                                   20


<210>  34764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34764
uuccuuccuu ccuuccuucc                                                   20


<210>  34765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34765
uuccuuccuu ccuuccuucu                                                   20


<210>  34766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34766
uuccuuccuu ccuucuuucc                                                   20


<210>  34767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34767
uuccuuccuu cuuuccuucc                                                   20


<210>  34768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34768
uuccuucuuu ccuuccuccc                                                   20


<210>  34769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34769
uucuuuccuu ccucccuucc                                                   20


<210>  34770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34770
uuccuuccuc ccuuccuccc                                                   20


<210>  34771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34771
uuccucccuu ccucccuccc                                                   20


<210>  34772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34772
ucccuuccuc ccucccuucc                                                   20


<210>  34773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34773
ucccucccuu cccuacuucc                                                   20


<210>  34774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34774
cuacuucccu cucccuuucc                                                   20


<210>  34775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34775
cucucccuuu cccuuucccu                                                   20


<210>  34776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34776
cuuucccuuc cccuuuuccc                                                   20


<210>  34777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34777
cuuccccuuu ucccuucccc                                                   20


<210>  34778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34778
ccuuuucccu uccccuuccc                                                   20


<210>  34779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34779
cuuccccuuc ccgccugccu                                                   20


<210>  34780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34780
ccuucccgcc ugccugccug                                                   20


<210>  34781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34781
cgccugccug ccugccugcc                                                   20


<210>  34782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34782
uuccuuccuu ccuucguuuc                                                   20


<210>  34783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34783
uuccuuccuu cguuucuuuc                                                   20


<210>  34784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34784
uuccuucguu ucuuucuaca                                                   20


<210>  34785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34785
uucguuucuu ucuacauaua                                                   20


<210>  34786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34786
uuucuuucua cauauacaca                                                   20


<210>  34787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34787
uucuacauau acacauuuuu                                                   20


<210>  34788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34788
acauauacac auuuuuuuaa                                                   20


<210>  34789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34789
augguuuuug ggguacaagu                                                   20


<210>  34790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34790
gccauguaac caaaaaccac                                                   20


<210>  34791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34791
ccauguaacc aaaauucagc                                                   20


<210>  34792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34792
agccuuccgc cuugugaguc                                                   20


<210>  34793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34793
gccuugugag ucuccaaugu                                                   20


<210>  34794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34794
gagaacauau agcagaaaca                                                   20


<210>  34795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34795
cagaaguggg agcugagcug                                                   20


<210>  34796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34796
gcuauauguu cucagaagug                                                   20


<210>  34797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34797
gguaguggga guauacuuug                                                   20


<210>  34798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34798
ucucaccagu acaaauauuu                                                   20


<210>  34799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34799
caccaguaca aauauuucaa                                                   20


<210>  34800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34800
aaaaaaguua aauauguauc                                                   20


<210>  34801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34801
gcccaaaaaa cugauacaua                                                   20


<210>  34802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34802
cuuuauuuau uuauuuuuuu                                                   20


<210>  34803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34803
augaugccca ggcuggagug                                                   20


<210>  34804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34804
agugauuccc acgucagccu                                                   20


<210>  34805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34805
cacgucagcc ucccaggaag                                                   20


<210>  34806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34806
ugggaggcug acgugggaau                                                   20


<210>  34807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34807
agcuuccugg gaggcugacg                                                   20


<210>  34808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34808
ccauguuggc cagacugguc                                                   20


<210>  34809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34809
aaagugcugg gauuacaggc                                                   20


<210>  34810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34810
uuuuaaaaua acuuaccuuc                                                   20


<210>  34811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34811
uuugaaagua auacauguuu                                                   20


<210>  34812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34812
aaagaaggua aguuauuuua                                                   20


<210>  34813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34813
uuaaacaugu auuacuuuca                                                   20


<210>  34814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34814
guucauuaaa cauguauuac                                                   20


<210>  34815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34815
uuaaauucug uucauuaaac                                                   20


<210>  34816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34816
uuuuuuuaua uuuuccuuaa                                                   20


<210>  34817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34817
guaguuugau uacaaagauu                                                   20


<210>  34818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34818
uuucaguagu uugauuacaa                                                   20


<210>  34819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34819
uuuucauuuu caucauugua                                                   20


<210>  34820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34820
uuuucaucau uguaauuugc                                                   20


<210>  34821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34821
ucauuguaau uugcauuucu                                                   20


<210>  34822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34822
uugauuacuu gugagacacu                                                   20


<210>  34823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34823
uuuacuuaau agguuuauau                                                   20


<210>  34824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34824
gagauuuugc agcuuuacca                                                   20


<210>  34825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34825
gcaaaugaua gcaacuucuu                                                   20


<210>  34826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34826
uuuuguuugu uuguuugugg                                                   20


<210>  34827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34827
ugccugagug acagagcgag                                                   20


<210>  34828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34828
accacugcau uccugccuga                                                   20


<210>  34829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34829
agcgauuuuc cugccucagc                                                   20


<210>  34830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34830
ugccucagcc ucccaaguag                                                   20


<210>  34831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34831
agaucagccc ggccaacaug                                                   20


<210>  34832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34832
uauauucuag aaaaaauucu                                                   20


<210>  34833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34833
agaaaaaauu cuacucauga                                                   20


<210>  34834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34834
agaauauaag aaguaacuac                                                   20


<210>  34835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34835
acucaugauc aagucuccau                                                   20


<210>  34836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34836
ucauggagac uugaucauga                                                   20


<210>  34837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34837
auuaaagucu cuuuccucau                                                   20


<210>  34838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34838
uuguuucuaa aaguauuacu                                                   20


<210>  34839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34839
aaaaguauua cugaguguug                                                   20


<210>  34840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34840
uaucugccau caacacucag                                                   20


<210>  34841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34841
uacaaaaaca aaaggguuca                                                   20


<210>  34842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34842
ccauuugaau ucaguuuaga                                                   20


<210>  34843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34843
aauggagaau acggguaaca                                                   20


<210>  34844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34844
guuuagauuu guuaggaauc                                                   20


<210>  34845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34845
uaacaaaucu aaacugaauu                                                   20


<210>  34846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34846
uuaggcacuu uugcaauuuu                                                   20


<210>  34847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34847
gaccugcucu gugcucagua                                                   20


<210>  34848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34848
gcacuuguug aucagaaggu                                                   20


<210>  34849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34849
gaucaacaag ugcugaacag                                                   20


<210>  34850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34850
aaaccuucug aucaacaagu                                                   20


<210>  34851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34851
cuuucuaaac cuucugauca                                                   20


<210>  34852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34852
aaguugguuu uuaauuaaag                                                   20


<210>  34853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34853
auuuacacua uuaaaugcuu                                                   20


<210>  34854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34854
uuugucuguc auaaaauuua                                                   20


<210>  34855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34855
agaguucaag aacagccugg                                                   20


<210>  34856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34856
agaacagccu ggccaaggug                                                   20


<210>  34857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34857
ugaacucuug aacuccugac                                                   20


<210>  34858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34858
ucaccuuggc caggcuguuc                                                   20


<210>  34859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34859
ccugccucag ccuccugagu                                                   20


<210>  34860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34860
agugauucuc cugccucagc                                                   20


<210>  34861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34861
gucucaaaaa aaaaaaaaaa                                                   20


<210>  34862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34862
uuuuuuuuuu uuuuugagac                                                   20


<210>  34863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34863
uuuuuucuuu uuuuuuuuuu                                                   20


<210>  34864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34864
agcacgugac agcguugucu                                                   20


<210>  34865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34865
ucaagcacgu gacagcguug                                                   20


<210>  34866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34866
cagguggcgu ucuucaagca                                                   20


<210>  34867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34867
cgcccccuuu cucagguggc                                                   20


<210>  34868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34868
ucuacuuucu uaagcaaauu                                                   20


<210>  34869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34869
uaagcaaauu aaccuuacuu                                                   20


<210>  34870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34870
gguaaacacu gcuuugaucu                                                   20


<210>  34871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34871
caugcaugag acgcagccuc                                                   20


<210>  34872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34872
ccgucagcac aauaaccagg                                                   20


<210>  34873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34873
cauugucggg aaaaugcccu                                                   20


<210>  34874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34874
cgacaaugug aagaugccac                                                   20


<210>  34875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34875
ugaugccuuu cuuuaggcuu                                                   20


<210>  34876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34876
uuaggcuuua auugaaaaca                                                   20


<210>  34877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34877
auuaaagccu aaagaaaggc                                                   20


<210>  34878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34878
agaaaaaagc uucagcucag                                                   20


<210>  34879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34879
agaaaauaaa auguuuucaa                                                   20


<210>  34880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34880
gcucaggaug uuugagugua                                                   20


<210>  34881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34881
augugcugac aguuguauuu                                                   20


<210>  34882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34882
cuuuaguugu guuaccuuua                                                   20


<210>  34883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34883
aucaugccug uugauuuuuu                                                   20


<210>  34884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34884
gugauuugcg agauuaucau                                                   20


<210>  34885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34885
cauuuauugu ggagcuuuug                                                   20


<210>  34886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34886
aaagcuccac aauaaaugug                                                   20


<210>  34887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34887
uaucugcuuc uuaggugagu                                                   20


<210>  34888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34888
uaggugagug ggacacagug                                                   20


<210>  34889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34889
uuaaagcacu gugucccacu                                                   20


<210>  34890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34890
gaauucuagc uugcagagaa                                                   20


<210>  34891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34891
gaagauuaua gcuucauuaa                                                   20


<210>  34892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34892
agcuugcaga gaagauugca                                                   20


<210>  34893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34893
cugcaagcua gaauucugaa                                                   20


<210>  34894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34894
gcaaucuucu cugcaagcua                                                   20


<210>  34895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34895
gcugaguaac aguguuuuac                                                   20


<210>  34896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34896
aagcuuaaau gaucacuuga                                                   20


<210>  34897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34897
gaauuaggaa cucagcuuau                                                   20


<210>  34898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34898
gaaaaaaagc aucaagugau                                                   20


<210>  34899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34899
uaauucagaa aaaaagcauc                                                   20


<210>  34900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34900
ugaauaaaua acgucuuuuu                                                   20


<210>  34901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34901
ggaauuauga cuuugauauu                                                   20


<210>  34902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34902
uguaaagacu gcuuuaaaaa                                                   20


<210>  34903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34903
auguguuuuu uaaagcaguc                                                   20


<210>  34904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34904
agaccaccca gggcaacaug                                                   20


<210>  34905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34905
caucccucag ccucccgagu                                                   20


<210>  34906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34906
ccucagauaa uuuccuuugu                                                   20


<210>  34907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34907
uuuguuuaaa cucagaacug                                                   20


<210>  34908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34908
gaguuuaaac aaaggaaauu                                                   20


<210>  34909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34909
cucuuggaga agauucagga                                                   20


<210>  34910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34910
ccaagagaga aaaugccagu                                                   20


<210>  34911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34911
ggacaaauac uccuuuaaga                                                   20


<210>  34912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34912
acuuaucuua aaggaguauu                                                   20


<210>  34913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34913
cugcuucuac uuaucuuaaa                                                   20


<210>  34914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34914
ugauaaucaa auccucuuuc                                                   20


<210>  34915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34915
aagcuuauca aauuccugau                                                   20


<210>  34916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34916
uaaugucauu ucagaagaug                                                   20


<210>  34917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34917
gaagaugaau auuuauuaau                                                   20


<210>  34918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34918
gaaaugacau uaagaagcaa                                                   20


<210>  34919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34919
ucuucugaaa ugacauuaag                                                   20


<210>  34920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34920
aaguaguagu uaguaaucaa                                                   20


<210>  34921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34921
aaacuucagc aggccucuug                                                   20


<210>  34922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34922
gcaggccucu ugacaauuca                                                   20


<210>  34923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34923
gcugugguca auugggucuu                                                   20


<210>  34924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34924
guuagcauuc auguguuaac                                                   20


<210>  34925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34925
uguguuaacu uaaaaucaua                                                   20


<210>  34926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34926
aaccacuggg guauuauaau                                                   20


<210>  34927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34927
uuuauaauuu auuuuauuuu                                                   20


<210>  34928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34928
auguguucua aaggaauuag                                                   20


<210>  34929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34929
aaaggaauua gaguuuguau                                                   20


<210>  34930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34930
uuuagaacac auggaaaaaa                                                   20


<210>  34931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34931
aucccccauu auaguuauau                                                   20


<210>  34932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34932
uggcacaugu caauuucuau                                                   20


<210>  34933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34933
cuucauggca caugucaauu                                                   20


<210>  34934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34934
caucucccac ggcacuuuuu                                                   20


<210>  34935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34935
ccacuucuca ucucccacgg                                                   20


<210>  34936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34936
uuucuccacu ucucaucucc                                                   20


<210>  34937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34937
uuuuucuugg aagcaggaau                                                   20


<210>  34938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34938
uggaagcagg aauaacuuca                                                   20


<210>  34939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34939
aagaaaaaag aaauuccuuu                                                   20


<210>  34940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34940
ugcuuccaag aaaaaagaaa                                                   20


<210>  34941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34941
ugaagcaugu auuucaacuu                                                   20


<210>  34942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34942
ugaaguuauu ccugcuucca                                                   20


<210>  34943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34943
acuuaaacag auaguaggca                                                   20


<210>  34944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34944
gggcagacug ggaggaaggg                                                   20


<210>  34945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34945
ucccagucug ccccgaacac                                                   20


<210>  34946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34946
cucccuuccu cccagucugc                                                   20


<210>  34947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34947
gccauuguua uggaauaaug                                                   20


<210>  34948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34948
auaacaaugg cugaauuuau                                                   20


<210>  34949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34949
gcccguuuca cuuaaaaguu                                                   20


<210>  34950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34950
cuuaaaaguu gagacugcuu                                                   20


<210>  34951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34951
aauaacaaaa auauagagac                                                   20


<210>  34952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34952
auagugacgu cuguuaugcu                                                   20


<210>  34953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34953
agaguuauug cagcaguuuc                                                   20


<210>  34954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34954
caugaacuaa ucacaucaac                                                   20


<210>  34955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34955
ugagaaacug cugcaauaac                                                   20


<210>  34956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34956
ugaucggucu uacugacauu                                                   20


<210>  34957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34957
uagcaagccu cauggauaag                                                   20


<210>  34958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34958
gugaaaagaa ucucagcuua                                                   20


<210>  34959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34959
cagaagcaca auuucuuagc                                                   20


<210>  34960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34960
uuucacagaa gcacaauuuc                                                   20


<210>  34961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34961
uggaguaagc ugagauucuu                                                   20


<210>  34962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34962
gauuauuaaa guaauacacg                                                   20


<210>  34963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34963
gccaauuuag gaagacacaa                                                   20


<210>  34964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34964
uaaauuggcu gaauuuuuuu                                                   20


<210>  34965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34965
ccacguuggc caggcuggua                                                   20


<210>  34966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34966
ccugccucag ccuccugagu                                                   20


<210>  34967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34967
agcgauucuc cugccucagc                                                   20


<210>  34968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34968
uuuuuuuuuu uuuuuuuuga                                                   20


<210>  34969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34969
uuucuuuuuu uuuuuuuuuu                                                   20


<210>  34970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34970
gauacauuac caaugcaggu                                                   20


<210>  34971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34971
cuuaguauau auuaccaggu                                                   20


<210>  34972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34972
agcaauucuc cugccucagc                                                   20


<210>  34973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34973
ccugccucag ccuccugagu                                                   20


<210>  34974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34974
ccauguuggu caggcugguc                                                   20


<210>  34975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34975
uauuauaaaa auguaaggcc                                                   20


<210>  34976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34976
aaugucagca acauaaauuc                                                   20


<210>  34977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34977
uuucuaaugu cagcaacaua                                                   20


<210>  34978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34978
uggauauuau gguucuuuuc                                                   20


<210>  34979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34979
uggauucuug gauauuaugg                                                   20


<210>  34980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34980
ccaaagcauc acacuauaua                                                   20


<210>  34981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34981
cucaauauua caauccagau                                                   20


<210>  34982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34982
gccuuuuuuc acucaauauu                                                   20


<210>  34983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34983
guuaagaaaa auaauauuua                                                   20


<210>  34984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34984
uaacugaaau ccgacuauac                                                   20


<210>  34985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34985
cacacuggca gauaaucacc                                                   20


<210>  34986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34986
ucuuuauauu uuucagauau                                                   20


<210>  34987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34987
uuauauuuuu cagauauucu                                                   20


<210>  34988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34988
gauauucuca aauuuucuaa                                                   20


<210>  34989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34989
caaauuuucu aaaaugagca                                                   20


<210>  34990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34990
aaaaugagca aguauaacuu                                                   20


<210>  34991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34991
gauaacaaaa guuauacuug                                                   20


<210>  34992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34992
aucucaaaaa auaaaaauaa                                                   20


<210>  34993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34993
uggguucaaa ugauucucug                                                   20


<210>  34994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34994
aaugauucuc uggccccagc                                                   20


<210>  34995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34995
cuggccccag ccuccugagu                                                   20


<210>  34996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34996
agccacucag gaggcugggg                                                   20


<210>  34997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34997
ccagguuggu caggcugguc                                                   20


<210>  34998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34998
agaccagccu gaccaaccug                                                   20


<210>  34999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  34999
uuugucaaau aaaauaaaaa                                                   20


<210>  35000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35000
auguuauaga agacuaaaua                                                   20


<210>  35001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35001
auaacaugga aguauuucuu                                                   20


<210>  35002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35002
cuugauuugu ucaaaauauc                                                   20


<210>  35003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35003
aaauaucgua aacuuugcuu                                                   20


<210>  35004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35004
aucccaagcc uacaacagug                                                   20


<210>  35005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35005
ugcccuuagg guuucugcag                                                   20


<210>  35006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35006
gcaggcuggu cagggagacg                                                   20


<210>  35007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35007
gccucucaac ugccccugca                                                   20


<210>  35008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35008
aggguguggg cagcacagga                                                   20


<210>  35009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35009
ugugcugccc acacccugga                                                   20


<210>  35010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35010
uugggauaua auugccauuc                                                   20


<210>  35011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35011
gauaacacgu guuugaggug                                                   20


<210>  35012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35012
uacuuuagac accucaaaca                                                   20


<210>  35013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35013
ucucauuguu uguacuuuuu                                                   20


<210>  35014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35014
cauuguuugu acuuuuuaua                                                   20


<210>  35015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35015
auaaaccuuu gugguguuug                                                   20


<210>  35016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35016
uucuucucag uuuggaugcu                                                   20


<210>  35017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35017
ucucaguuug gaugcuguga                                                   20


<210>  35018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35018
caguuuggau gcugugaagc                                                   20


<210>  35019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35019
cagcauccaa acugagaaga                                                   20


<210>  35020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35020
uuccacugcc uucccaguuu                                                   20


<210>  35021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35021
acugccuucc caguuugcau                                                   20


<210>  35022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35022
caguuugcau uuggaguuua                                                   20


<210>  35023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35023
ucaguauaua uuaauaguug                                                   20


<210>  35024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35024
uucuuuuuaa gucuuuuauc                                                   20


<210>  35025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35025
uuuuaagucu uuuaucaauu                                                   20


<210>  35026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35026
aaaaagccaa auugauaaaa                                                   20


<210>  35027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35027
aucagauauu uuuccaaaaa                                                   20


<210>  35028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35028
gcuauauuag cugugugaga                                                   20


<210>  35029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35029
cacagcuccu gucacuaguc                                                   20


<210>  35030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35030
uuucccacag cuccugucac                                                   20


<210>  35031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35031
uaggcauuga ugggaauuuc                                                   20


<210>  35032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35032
caucaaugcc uaagaacauu                                                   20


<210>  35033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35033
gggugugguc uucaaguuca                                                   20


<210>  35034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35034
aguucauuua agggaauuuu                                                   20


<210>  35035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35035
uuuaagggaa uuuucauaug                                                   20


<210>  35036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35036
cuuaaaugaa cuugaagacc                                                   20


<210>  35037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35037
uaugcuggca aaaggcuuuu                                                   20


<210>  35038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35038
cauuagcuug acucuuucca                                                   20


<210>  35039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35039
aaaauuauuu gcugugaauu                                                   20


<210>  35040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35040
cagcaaauaa uuuuggaaag                                                   20


<210>  35041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35041
aauucacagc aaauaauuuu                                                   20


<210>  35042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35042
uaaacuucua auucacagca                                                   20


<210>  35043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35043
cuuaauugug accuagcaua                                                   20


<210>  35044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35044
uaugcuaggu cacaauuaag                                                   20


<210>  35045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35045
uaaaucauca ccauuucgua                                                   20


<210>  35046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35046
uguauuaaca gcuuuuauuu                                                   20


<210>  35047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35047
uccaguagau ggcccuacua                                                   20


<210>  35048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35048
cagaugcuag uagggccauc                                                   20


<210>  35049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35049
agucuucucc agcauucagg                                                   20


<210>  35050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35050
ccagcauuca ggaauaggcu                                                   20


<210>  35051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35051
ggaauaggcu uucauuuugu                                                   20


<210>  35052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35052
ugaaugcugg agaagacuug                                                   20


<210>  35053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35053
uuuuguguau caauuacuga                                                   20


<210>  35054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35054
caguaauuga uacacaaaau                                                   20


<210>  35055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35055
caaaugugau gugagucacc                                                   20


<210>  35056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35056
uguguguguc agcaaaugac                                                   20


<210>  35057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35057
agcaaauauc aguuggucau                                                   20


<210>  35058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35058
agagcagaua auguaaucca                                                   20


<210>  35059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35059
caccuuccuc acauacagac                                                   20


<210>  35060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35060
ucacauacag acugagcagc                                                   20


<210>  35061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35061
aaucauaggu cuggcacuag                                                   20


<210>  35062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35062
cuucugggca acuuuggcau                                                   20


<210>  35063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35063
gggcaacuuu ggcauuggag                                                   20


<210>  35064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35064
uuaaauuaau acauuuuacu                                                   20


<210>  35065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35065
aguaaacaua caguucuaau                                                   20


<210>  35066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35066
aauacuuuuu acaauuuaaa                                                   20


<210>  35067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35067
uuuuuauuuu aucauuuaaa                                                   20


<210>  35068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35068
gcaucuguuc acaagggguu                                                   20


<210>  35069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35069
caagggguug auauuuauga                                                   20


<210>  35070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35070
auucuccaua uccauucuau                                                   20


<210>  35071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35071
ccauauccau ucuauguucu                                                   20


<210>  35072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35072
auguucucuu aaugcucagu                                                   20


<210>  35073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35073
cuuaaugcuc agucagcacc                                                   20


<210>  35074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35074
augcuuggua guuugacuua                                                   20


<210>  35075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35075
aggggauuga gcccugggua                                                   20


<210>  35076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35076
auaacuuuua cuacaagaua                                                   20


<210>  35077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35077
ccaaugguau ccuuuaacac                                                   20


<210>  35078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35078
ugauauuauu auguugguuc                                                   20


<210>  35079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35079
auaguaauaa agaguucacc                                                   20


<210>  35080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35080
ccccagccaa uucucuuuua                                                   20


<210>  35081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35081
cuuuuauuuu gugccuguuu                                                   20


<210>  35082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35082
gcagaaccau ugucauaugc                                                   20


<210>  35083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35083
gcugaacugg agaugagaca                                                   20


<210>  35084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35084
uucauuggac acuuaggccc                                                   20


<210>  35085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35085
uuggacacuu aggccccaau                                                   20


<210>  35086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35086
uucagaucua cuaccugauu                                                   20


<210>  35087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35087
gaucuacuac cugauuucau                                                   20


<210>  35088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35088
uuucucaaau gauuuuuaug                                                   20


<210>  35089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35089
caaaugauuu uuauggagcu                                                   20


<210>  35090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35090
uauaaaucag agcuccauaa                                                   20


<210>  35091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35091
gagcugguau aaaauguauu                                                   20


<210>  35092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35092
ucuuggaauu gcaagagaaa                                                   20


<210>  35093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35093
aagaggaagg caugucacaa                                                   20


<210>  35094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35094
cuugcaauuc caagaggaag                                                   20


<210>  35095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35095
uuucucuugc aauuccaaga                                                   20


<210>  35096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35096
agagugccuc cacugagugc                                                   20


<210>  35097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35097
uagacucauc ugaggcacuc                                                   20


<210>  35098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35098
gacccugcuc ucgucagcuu                                                   20


<210>  35099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35099
cauuggaucu cucagcccau                                                   20


<210>  35100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35100
ggccaaaauc aaagcaucuu                                                   20


<210>  35101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35101
acucaguacc aguaccugca                                                   20


<210>  35102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35102
uuagggggaa uggggguggu                                                   20


<210>  35103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35103
cccuaaggaa aucaaaaucc                                                   20


<210>  35104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35104
ccucauaugc ucaccacccc                                                   20


<210>  35105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35105
gauguuaccu auaugcauaa                                                   20


<210>  35106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35106
gugcugagua uuuuaaagua                                                   20


<210>  35107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35107
caauauagcc ccucaguuaa                                                   20


<210>  35108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35108
aaaugaguuu acuuguaguu                                                   20


<210>  35109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35109
uuuuaauggg caccauaugc                                                   20


<210>  35110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35110
uaacauccca gugcccgagg                                                   20


<210>  35111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35111
uucucaaguu aguuuuagau                                                   20


<210>  35112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35112
caaguuaguu uuagauuaga                                                   20


<210>  35113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35113
uaccagccca uaaaucugcc                                                   20


<210>  35114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35114
uugcuggcca cauccuccau                                                   20


<210>  35115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35115
auggacuccg ucuuccuugc                                                   20


<210>  35116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35116
cccaaaauca auuucaaugg                                                   20


<210>  35117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35117
uggagauugg caacuucucc                                                   20


<210>  35118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35118
uucauggaga uuggcaacuu                                                   20


<210>  35119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35119
gggggcuaua ggagaguuuc                                                   20


<210>  35120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35120
ugaaagggac uaaaagauga                                                   20


<210>  35121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35121
cgaaacucuc cuauagcccc                                                   20


<210>  35122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35122
uccaacuuga acaugggcug                                                   20


<210>  35123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35123
aguuggauga augaucuuau                                                   20


<210>  35124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35124
ccuccagccc auguucaagu                                                   20


<210>  35125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35125
cuacaguccc aaagccauua                                                   20


<210>  35126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35126
cuuacaauca gugucuuccc                                                   20


<210>  35127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35127
uucucuuaca aucagugucu                                                   20


<210>  35128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35128
gccuccuuca uucucuuaca                                                   20


<210>  35129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35129
ccaacugaac uucgguugug                                                   20


<210>  35130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35130
guuggugaac caggccuggc                                                   20


<210>  35131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35131
guugugaaga caaagaaacc                                                   20


<210>  35132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35132
caaccgaagu ucaguuggug                                                   20


<210>  35133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35133
uugucuucac aaccgaaguu                                                   20


<210>  35134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35134
cauccugggc aggugugugg                                                   20


<210>  35135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35135
augacuguca ccaccacaca                                                   20


<210>  35136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35136
caauuuccau gacugucacc                                                   20


<210>  35137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35137
cgcacaaauc uguguuccca                                                   20


<210>  35138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35138
guuugaguuu ggcuuaucag                                                   20


<210>  35139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35139
acugauaagc caaacucaaa                                                   20


<210>  35140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35140
guuccccaag caauuugucc                                                   20


<210>  35141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35141
ccaagcaauu uguccuuccc                                                   20


<210>  35142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35142
caugcuauug ggguggagag                                                   20


<210>  35143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35143
cagagauuug ggagcacugg                                                   20


<210>  35144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35144
ugggccucug aagaagaagc                                                   20


<210>  35145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35145
gaggcccaug aacuucucag                                                   20


<210>  35146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35146
ucagaggccc augaacuucu                                                   20


<210>  35147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35147
ucuucagagg cccaugaacu                                                   20


<210>  35148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35148
cucaccugcu gaaggugauu                                                   20


<210>  35149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35149
gcaggugaga gaagagcugc                                                   20


<210>  35150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35150
uacagccuua augacuaugg                                                   20


<210>  35151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35151
agacuaccuu uguuuaguaa                                                   20


<210>  35152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35152
uuauucucuu uuugcuuuaa                                                   20


<210>  35153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35153
cuuuuugcuu uaaaugaaca                                                   20


<210>  35154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35154
uuuaaagcaa aaagagaaua                                                   20


<210>  35155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35155
agcacuuugg gagacugagg                                                   20


<210>  35156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35156
agaccagccu gggcaacauc                                                   20


<210>  35157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35157
ugauguugcc caggcugguc                                                   20


<210>  35158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35158
cuguguuagc caggaugguc                                                   20


<210>  35159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35159
ccugccucag ccucccgagc                                                   20


<210>  35160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35160
cgccauucuc cugccucagc                                                   20


<210>  35161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35161
agcaacucuc uugccucagc                                                   20


<210>  35162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35162
aaaagaagaa aaaaauguga                                                   20


<210>  35163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35163
uuuggaaaga gucugacucu                                                   20


<210>  35164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35164
ucuuuuggaa agagucugac                                                   20


<210>  35165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35165
cucuuaggga uaacagugac                                                   20


<210>  35166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35166
agcauuagcc aagaaagcuc                                                   20


<210>  35167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35167
uggcuaaugc uggaaaccua                                                   20


<210>  35168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35168
gagcuuucuu ggcuaaugcu                                                   20


<210>  35169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35169
uggccaagua ccucauugcu                                                   20


<210>  35170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35170
augguuguag aauguucugc                                                   20


<210>  35171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35171
acaaccaugg aaaugcucca                                                   20


<210>  35172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35172
gccaaucuca gggacaguuu                                                   20


<210>  35173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35173
gugaagcaau aaaaucaacu                                                   20


<210>  35174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35174
cagaaaagca aaacuguccc                                                   20


<210>  35175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35175
aaacaaaugu uaacuauuug                                                   20


<210>  35176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35176
cauacuuuuu uuuuuuuuuu                                                   20


<210>  35177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35177
uucuuguugc cugggcugga                                                   20


<210>  35178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35178
uguugccugg gcuggagugc                                                   20


<210>  35179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35179
gccuccuggg uucaaacgau                                                   20


<210>  35180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35180
aacgauucuu cugccucagc                                                   20


<210>  35181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35181
ucugccucag ccucucgagg                                                   20


<210>  35182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35182
gccucagccu cucgaggcag                                                   20


<210>  35183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35183
ccauguuggu cagguugguc                                                   20


<210>  35184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35184
ggucaggagu uugagaccaa                                                   20


<210>  35185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35185
gccucccaaa guguugggau                                                   20


<210>  35186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35186
cuuacuguuu auaucugauu                                                   20


<210>  35187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35187
accuuuaaaa aucucccuac                                                   20


<210>  35188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35188
cauucuccuu uagcugccau                                                   20


<210>  35189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35189
ccuuuagcug ccaucagucu                                                   20


<210>  35190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35190
cccuucucug caaacaucuc                                                   20


<210>  35191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35191
cugcaaacau cucuggagag                                                   20


<210>  35192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35192
cacugcucug agguggaccu                                                   20


<210>  35193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35193
uuggcucucu uggccuggac                                                   20


<210>  35194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35194
gccauccuuc cuuaaccccu                                                   20


<210>  35195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35195
uuaaccccug cuggugguuu                                                   20


<210>  35196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35196
guugccacac uccauagcag                                                   20


<210>  35197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35197
cgcccagauc augucuuuac                                                   20


<210>  35198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35198
cucuuuguau ccugcaggcu                                                   20


<210>  35199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35199
guuggcuuuc agagggccuc                                                   20


<210>  35200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35200
gagggccucc uggguguucc                                                   20


<210>  35201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35201
cuuacccacu ugccacuccc                                                   20


<210>  35202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35202
guccuuccug cccaccagca                                                   20


<210>  35203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35203
ugcccaccag cacaugcuuu                                                   20


<210>  35204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35204
aggcucuguc cuaggccguc                                                   20


<210>  35205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35205
cucuuuguag ucucugggcc                                                   20


<210>  35206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35206
agagaguggc agaauuuucu                                                   20


<210>  35207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35207
gccacucucu agaacagcac                                                   20


<210>  35208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35208
auaaccaugg cagugcucca                                                   20


<210>  35209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35209
agggcucaac agcuauaugu                                                   20


<210>  35210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35210
gucacacuag cugcauuuca                                                   20


<210>  35211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35211
ucagucacac uagcugcauu                                                   20


<210>  35212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35212
guucuucagu cacacuagcu                                                   20


<210>  35213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35213
guuuaauuuu cauuaaauuu                                                   20


<210>  35214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35214
uuaaauuuaa auuuaaauaa                                                   20


<210>  35215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35215
ccugucuuca gugucuagau                                                   20


<210>  35216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35216
gugucuagau gagggaccuc                                                   20


<210>  35217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35217
auguagccag cugccccgug                                                   20


<210>  35218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35218
guccuccucc ccacaucugc                                                   20


<210>  35219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35219
agcuugauaa gacacaaagu                                                   20


<210>  35220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35220
uuuccacuca ccaagucuuu                                                   20


<210>  35221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35221
acucaccaag ucuuuuguuu                                                   20


<210>  35222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35222
ccuacuaaau auuuugcgag                                                   20


<210>  35223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35223
cgcaaaauau uuaguagggg                                                   20


<210>  35224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35224
ucucgcaaaa uauuuaguag                                                   20


<210>  35225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35225
cauacaugua caugcacaua                                                   20


<210>  35226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35226
agaacuuugg gaggccgaga                                                   20


<210>  35227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35227
ggaauuacag gcgugagcca                                                   20


<210>  35228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35228
ggcucacacg gugaaacccc                                                   20


<210>  35229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35229
ccgugugagc cggaaugguc                                                   20


<210>  35230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35230
ccugcaucag ccucccaggu                                                   20


<210>  35231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35231
cgccguucuc cugcaucagc                                                   20


<210>  35232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35232
ugugcagccu gguuuuuuuu                                                   20


<210>  35233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35233
uccugugcag ccugguuuuu                                                   20


<210>  35234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35234
cauaggagcg uguaugaguu                                                   20


<210>  35235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35235
uucucacacu ucuguaaaga                                                   20


<210>  35236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35236
cacacuucug uaaagacaua                                                   20


<210>  35237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35237
guaaagacau accugagaca                                                   20


<210>  35238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35238
uuauaugucu cagguauguc                                                   20


<210>  35239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35239
gcaggcugua caggcuucug                                                   20


<210>  35240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35240
guuucuggga aggccucagg                                                   20


<210>  35241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35241
gggaaggccu caggaaacuu                                                   20


<210>  35242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35242
cagaaacaga agccuguaca                                                   20


<210>  35243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35243
ugaggccuuc ccagaaacag                                                   20


<210>  35244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35244
gccaugacug caaguuuccu                                                   20


<210>  35245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35245
ccuucugcca ugacugcaag                                                   20


<210>  35246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35246
ccuucaccuu cugccaugac                                                   20


<210>  35247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35247
cauggcccac aggaaaaaga                                                   20


<210>  35248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35248
ugugggccau gugaagaugu                                                   20


<210>  35249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35249
cucuuuuucc ugugggccau                                                   20


<210>  35250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35250
cucucucucu cugucucucu                                                   20


<210>  35251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35251
uuuucucucu cucucucugu                                                   20


<210>  35252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35252
cccuccucuc ucccucucaa                                                   20


<210>  35253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35253
aaugguugag caccaucccc                                                   20


<210>  35254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35254
gcaugagauu ugggugggga                                                   20


<210>  35255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35255
ugcucugaua ugguuuggcu                                                   20


<210>  35256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35256
caauaggguu caugcucuga                                                   20


<210>  35257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35257
cauaaggagc augcaaccua                                                   20


<210>  35258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35258
accucaaauc aucaucaggc                                                   20


<210>  35259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35259
ucccgaaacc aucccccgcc                                                   20


<210>  35260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35260
ggaugaaacu guuccaccuc                                                   20


<210>  35261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35261
acaaaccagg guuggcgggg                                                   20


<210>  35262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35262
acagaaccgg ucccuggugc                                                   20


<210>  35263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35263
guggaagaca auuuuuccac                                                   20


<210>  35264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35264
cugccacuuc ugguccagac                                                   20


<210>  35265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35265
gguccagacu gauauacuau                                                   20


<210>  35266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35266
aaaacaaaag gcuagugcag                                                   20


<210>  35267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35267
guugcccagc uuggagugca                                                   20


<210>  35268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35268
gccucagccu ucucaguagu                                                   20


<210>  35269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35269
caguaguugg gacuacaggc                                                   20


<210>  35270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35270
gccucccagg uucaagugau                                                   20


<210>  35271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35271
agugauucuc cugccucagc                                                   20


<210>  35272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35272
ccugccucag ccucccgagu                                                   20


<210>  35273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35273
ccauguuggc caggcugguc                                                   20


<210>  35274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35274
agaccagccu ggccaacaug                                                   20


<210>  35275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35275
uggcugggag cgguagcuca                                                   20


<210>  35276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35276
ugagauaauu cauauaauuc                                                   20


<210>  35277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35277
uauaauucac ccauuuaaag                                                   20


<210>  35278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35278
cccauuuaaa guauauaauu                                                   20


<210>  35279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35279
uucucuuuag uaugcccaca                                                   20


<210>  35280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35280
cuuuaguaug cccacagagu                                                   20


<210>  35281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35281
ggugauggcu guacaacucu                                                   20


<210>  35282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35282
aaaacugauu cuggugaugg                                                   20


<210>  35283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35283
uuuauggguu cuaaaacuga                                                   20


<210>  35284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35284
gucucuguga cucuacgucu                                                   20


<210>  35285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35285
ggacauuacu guggaugggc                                                   20


<210>  35286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35286
accaagcagg guuuucagug                                                   20


<210>  35287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35287
guguagcagc cucucuguuu                                                   20


<210>  35288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35288
uuuuuuuuua aauugugacg                                                   20


<210>  35289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35289
gucacaauuu aaaaaaaaaa                                                   20


<210>  35290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35290
gccucccggg uucaagcgau                                                   20


<210>  35291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35291
agcgauucuc cugccucagc                                                   20


<210>  35292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35292
ccugccucag ccucccgagu                                                   20


<210>  35293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35293
acauguuagc cagggugguc                                                   20


<210>  35294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35294
ugauccgccu gccucggccu                                                   20


<210>  35295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35295
uuuacugucu gcauuucuuc                                                   20


<210>  35296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35296
ucccugaugc cuuccagucc                                                   20


<210>  35297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35297
cugaugccuu ccaguccaug                                                   20


<210>  35298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35298
aguccaugca cccgauugua                                                   20


<210>  35299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35299
uccuauuaug guuuaaggug                                                   20


<210>  35300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35300
acaacagaau uuacuucuca                                                   20


<210>  35301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35301
guuguugaag ccacccaggc                                                   20


<210>  35302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35302
cacacuucug gagguuggga                                                   20


<210>  35303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35303
ggagguuggg aaguccaaga                                                   20


<210>  35304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35304
caaccuccag aagugugaga                                                   20


<210>  35305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35305
ccuugcccuc auguggugag                                                   20


<210>  35306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35306
ucacccccuc accacaugag                                                   20


<210>  35307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35307
ugaggggucu gcccucauga                                                   20


<210>  35308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35308
guguauaaau uugggggacu                                                   20


<210>  35309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35309
augucuauag ucccccaaau                                                   20


<210>  35310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35310
aagaucaggg agugaguaag                                                   20


<210>  35311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35311
acaugucagu caucuugccu                                                   20


<210>  35312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35312
cucugcucca ugauggcugc                                                   20


<210>  35313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35313
auaugcucuc auguguugug                                                   20


<210>  35314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35314
uaaagccuca acuaucucca                                                   20


<210>  35315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35315
agcuuugcug guaaccagcu                                                   20


<210>  35316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35316
aggucacagc ugguuaccag                                                   20


<210>  35317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35317
ucucugagcc uguuuccucu                                                   20


<210>  35318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35318
ucuuuuagaa acaggaguuu                                                   20


<210>  35319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35319
aaaagaggaa acaggcucag                                                   20


<210>  35320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35320
agcacuuugg gaggcugaga                                                   20


<210>  35321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35321
agaccagccu gggcaucaua                                                   20


<210>  35322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35322
ugaggagaca ggaucucaca                                                   20


<210>  35323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35323
uuguagccuc aaccuccugg                                                   20


<210>  35324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35324
uuuuugagac agggucucac                                                   20


<210>  35325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35325
ugucauggcg ucauggccaa                                                   20


<210>  35326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35326
auguuggcca ugacgccaug                                                   20


<210>  35327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35327
aucuucaacu cauucucugu                                                   20


<210>  35328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35328
acucauucuc ugugcaccug                                                   20


<210>  35329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35329
cugugcaccu guuaggaagu                                                   20


<210>  35330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35330
uaacaggugc acagagaaug                                                   20


<210>  35331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35331
gacacuguac acauuuuauu                                                   20


<210>  35332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35332
uggacccuga uauguacagu                                                   20


<210>  35333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35333
aauuuucagu uuuguuauac                                                   20


<210>  35334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35334
guuuuguuau acuuccauca                                                   20


<210>  35335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35335
aucacauguu uuuguuuuuu                                                   20


<210>  35336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35336
auuuuaggca gccuugccuu                                                   20


<210>  35337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35337
cuaacaaacc ccccuucucu                                                   20


<210>  35338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35338
cuaaguccca uccgacgaaa                                                   20


<210>  35339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35339
ucggauggga cuuagagaag                                                   20


<210>  35340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35340
ccuuucgucg gaugggacuu                                                   20


<210>  35341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35341
ccuuccccuu ucgucggaug                                                   20


<210>  35342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35342
uucuccuucc ccuuucgucg                                                   20


<210>  35343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35343
ccugguucuu ucuccuuccc                                                   20


<210>  35344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35344
ugggacucaa cgguacagau                                                   20


<210>  35345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35345
uaccugcacu ggccucacug                                                   20


<210>  35346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35346
ccacgcuguu uccuaccugc                                                   20


<210>  35347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35347
acaugacaga ugcugcacuc                                                   20


<210>  35348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35348
cuaaaacacc aaguuacuua                                                   20


<210>  35349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35349
cucacuuuac ugauguguau                                                   20


<210>  35350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35350
ccaggugcgg uucaagauau                                                   20


<210>  35351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35351
agauauuaga aacuaaugac                                                   20


<210>  35352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35352
aauaucuuga accgcaccug                                                   20


<210>  35353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35353
gaccaaaagg uggucugugu                                                   20


<210>  35354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35354
aagugccacu ggcugacaug                                                   20


<210>  35355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35355
agcccuagca uggagcauca                                                   20


<210>  35356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35356
cugguugcag gugauggcug                                                   20


<210>  35357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35357
guaagggaag ugguguagau                                                   20


<210>  35358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35358
cuuacugaaa aucaggaggc                                                   20


<210>  35359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35359
uaagcaucua caccacuucc                                                   20


<210>  35360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35360
cucacuacau cuauuccuaa                                                   20


<210>  35361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35361
gauaugucaa aaauucugau                                                   20


<210>  35362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35362
gauuggaaau ggaauauuua                                                   20


<210>  35363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35363
aaucagaauu uuugacauau                                                   20


<210>  35364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35364
auuuccaauc agaauuuuug                                                   20


<210>  35365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35365
aaauguaaau auuccauuuc                                                   20


<210>  35366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35366
cucgccuuua gcucuuccaa                                                   20


<210>  35367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35367
caaguuugga ggaccuuuuu                                                   20


<210>  35368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35368
uggguaaaaa aagguccucc                                                   20


<210>  35369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35369
gaccuuuuca uggguaaaaa                                                   20


<210>  35370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35370
guucugaccu uuucaugggu                                                   20


<210>  35371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35371
auaaacugca gucacaccua                                                   20


<210>  35372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35372
cauccauacu gcucucggug                                                   20


<210>  35373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35373
ugcuuugcca ggcuccucuc                                                   20


<210>  35374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35374
cacgcugucu cuuggcaccc                                                   20


<210>  35375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35375
cccauuuguu uuguguauau                                                   20


<210>  35376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35376
agcaauucuc cugccucagc                                                   20


<210>  35377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35377
ccugccucag ccuccugagu                                                   20


<210>  35378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35378
ccuuguuggc caggaugguc                                                   20


<210>  35379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35379
aacaucaugu uguauauuac                                                   20


<210>  35380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35380
agaccaaacu ggccagcaug                                                   20


<210>  35381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35381
ccaugcuggc caguuugguc                                                   20


<210>  35382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35382
ccugccucag ccucccaagu                                                   20


<210>  35383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35383
agcaauucuc cugccucagc                                                   20


<210>  35384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35384
ugccacugca cucuagccug                                                   20


<210>  35385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35385
uuuuuuuuuu uuuuugagac                                                   20


<210>  35386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35386
ucuuuuuuuu uuuuuuuuga                                                   20


<210>  35387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35387
acaaugcaua uguauuucuu                                                   20


<210>  35388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35388
caccacaaaa caaugauacg                                                   20


<210>  35389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35389
gugauuuucu ugcauauggu                                                   20


<210>  35390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35390
ugcauauggu acauugcuau                                                   20


<210>  35391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35391
agagaucuac uguauagcau                                                   20


<210>  35392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35392
uccugucuau aaaugaaauu                                                   20


<210>  35393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35393
uuuauagaca ggaggaauga                                                   20


<210>  35394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35394
agguuuuuuu ugagauggag                                                   20


<210>  35395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35395
ucacccaggc uggaguacca                                                   20


<210>  35396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35396
cccaggcugg aguaccaugg                                                   20


<210>  35397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35397
agcaauucuc cugccucagc                                                   20


<210>  35398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35398
ccugccucag ccuccugagu                                                   20


<210>  35399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35399
acuaaaaaua caaaaauuag                                                   20


<210>  35400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35400
ccauguuggc caggcugguc                                                   20


<210>  35401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35401
agaccagccu ggccaacaug                                                   20


<210>  35402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35402
aaggauugac uguaguacag                                                   20


<210>  35403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35403
uccuguacua cagucaaucc                                                   20


<210>  35404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35404
acaggucaau cuuccuccug                                                   20


<210>  35405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35405
gaugaauuaa auaaacuaag                                                   20


<210>  35406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35406
ucagaaagau gauaguaaua                                                   20


<210>  35407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35407
aacugaagua gaauaguugu                                                   20


<210>  35408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35408
guuugaagac uuuugacuug                                                   20


<210>  35409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35409
acuucaguuu gaagacuuuu                                                   20


<210>  35410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35410
ugagcacacc aaguaaucaa                                                   20


<210>  35411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35411
uuaguggcca acaacuucau                                                   20


<210>  35412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35412
ggaauuggcc agugguccuu                                                   20


<210>  35413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35413
agaaccucuc ugagccuaag                                                   20


<210>  35414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35414
aggaccacug gccaauucca                                                   20


<210>  35415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35415
cuaacugauu ucucacaaag                                                   20


<210>  35416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35416
cacaaagcaa acaagcaauc                                                   20


<210>  35417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35417
uauuuuguua uuuaaaaagu                                                   20


<210>  35418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35418
cauuacuucu aguuaaucaa                                                   20


<210>  35419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35419
aguuaaucaa aaggucagag                                                   20


<210>  35420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35420
ucugaccuuu ugauuaacua                                                   20


<210>  35421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35421
aguauuuccu cugaccuuuu                                                   20


<210>  35422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35422
uacuagaaua cuuuaaaaaa                                                   20


<210>  35423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35423
aguaugaaaa uauucaagua                                                   20


<210>  35424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35424
aguaaucucu uuaaaacuug                                                   20


<210>  35425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35425
agacaaucug auaccucagg                                                   20


<210>  35426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35426
aucaucuucc uucauaccuc                                                   20


<210>  35427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35427
uucauaccuc aaacugcaug                                                   20


<210>  35428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35428
uaccucaaac ugcaugaugu                                                   20


<210>  35429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35429
ggacaucaug caguuugagg                                                   20


<210>  35430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35430
uaugauuugu aggauguaua                                                   20


<210>  35431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35431
aguuuguuug ucuuucagcu                                                   20


<210>  35432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35432
gcuuuguuua ugauagcuuc                                                   20


<210>  35433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35433
aucauacagg uguuuuggau                                                   20


<210>  35434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35434
uauuguuugu acucacagcu                                                   20


<210>  35435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35435
cccuauaacc uggcugcaca                                                   20


<210>  35436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35436
uucccucccg ugaggcucac                                                   20


<210>  35437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35437
cucccgugag gcucacacaa                                                   20


<210>  35438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35438
agacucacag aagaaaagca                                                   20


<210>  35439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35439
gugagucugg aauuguggcu                                                   20


<210>  35440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35440
ucugugaguc uggaauugug                                                   20


<210>  35441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35441
gcauaaacca uguguuucaa                                                   20


<210>  35442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35442
aauagucugg gcauggugag                                                   20


<210>  35443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35443
cuagcugaua acaaguggcu                                                   20


<210>  35444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35444
uacgcugaca uaaacuuucc                                                   20


<210>  35445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35445
ccagauaccc ccaagagcca                                                   20


<210>  35446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35446
gucuagggau guuuuaguuu                                                   20


<210>  35447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35447
uuuuuuuuuu uaacuuuaaa                                                   20


<210>  35448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35448
guucaucugc aauuuguuag                                                   20


<210>  35449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35449
ucugcaauuu guuagauaug                                                   20


<210>  35450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35450
uaucuaacaa auugcagaug                                                   20


<210>  35451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35451
guaaacauua uuggggacaa                                                   20


<210>  35452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35452
ucuguaaaca uuauugggga                                                   20


<210>  35453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35453
gcacuaauug gcuugaguua                                                   20


<210>  35454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35454
cauaguucuc uaguuucagu                                                   20


<210>  35455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35455
cuaguuucag uaguuucauu                                                   20


<210>  35456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35456
guaguuucau uuauuauuuu                                                   20


<210>  35457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35457
uuuauuauuu uguuauauca                                                   20


<210>  35458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35458
aauagaugag cagacagaua                                                   20


<210>  35459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35459
uuuuuagaca gagucuugcu                                                   20


<210>  35460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35460
uaauuauugu agcuuaaugg                                                   20


<210>  35461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35461
ccuguuguuc uuuagaauuu                                                   20


<210>  35462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35462
uuagaauuuu cuggauauuc                                                   20


<210>  35463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35463
aaagaacaac aggggaacug                                                   20


<210>  35464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35464
ggauauucuu cuuuauugau                                                   20


<210>  35465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35465
ucuuuauuga uuuugggaug                                                   20


<210>  35466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35466
uuauugauuu ugggauguga                                                   20


<210>  35467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35467
caucccaaaa ucaauaaaga                                                   20


<210>  35468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35468
auuguucaca ucccaaaauc                                                   20


<210>  35469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35469
acuuguagau ugauuuaggg                                                   20


<210>  35470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35470
cccuaaauca aucuacaagu                                                   20


<210>  35471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35471
ggacagggug acuuaacauc                                                   20


<210>  35472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35472
uauuuguuca gaacuuuuua                                                   20


<210>  35473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35473
gaacuuuuua aauuaccuca                                                   20


<210>  35474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35474
gaacaaauag gaaagcaucc                                                   20


<210>  35475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35475
gagguaauuu aaaaaguucu                                                   20


<210>  35476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35476
ugugcuucug agguaauuua                                                   20


<210>  35477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35477
cauagcucuu gcacauuucu                                                   20


<210>  35478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35478
ugauaaauga auccucaggu                                                   20


<210>  35479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35479
uuuaucaaga aaugugcaag                                                   20


<210>  35480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35480
ucuguuuuug uuacuaauag                                                   20


<210>  35481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35481
uauggguuuu uuuuccccug                                                   20


<210>  35482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35482
ccugaaaauc auuuaucaaa                                                   20


<210>  35483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35483
ggggaaaaaa aacccauaag                                                   20


<210>  35484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35484
gaaggauguu ugauaauuuu                                                   20


<210>  35485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35485
gaaaauaagc cacauacguu                                                   20


<210>  35486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35486
aaaauuauca aacauccuuc                                                   20


<210>  35487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35487
uaucuuccaa aauuaucaaa                                                   20


<210>  35488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35488
uauuuuacaa gguuugaggu                                                   20


<210>  35489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35489
caugucagcu cccaaagcag                                                   20


<210>  35490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35490
gcuuugggag cugacaugag                                                   20


<210>  35491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35491
acaugccguc uucugcuuug                                                   20


<210>  35492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35492
cuacggcauu uuucaacaug                                                   20


<210>  35493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35493
uuuccaccug uuuucaacuc                                                   20


<210>  35494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35494
accuguuuuc aacucauauc                                                   20


<210>  35495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35495
acucauauca ucuugaauuu                                                   20


<210>  35496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35496
agaugauaug aguugaaaac                                                   20


<210>  35497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35497
gggcaccuuu ccaugcuccu                                                   20


<210>  35498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35498
augcuccuag ugcuugcuau                                                   20


<210>  35499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35499
uuccugaaua cccugaacuc                                                   20


<210>  35500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35500
ugaauacccu gaacuccagc                                                   20


<210>  35501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35501
ggaaggaaaa uaauaaacag                                                   20


<210>  35502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35502
ggguauucag gaaggaaaau                                                   20


<210>  35503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35503
gcuguaauuc uggccucccu                                                   20


<210>  35504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35504
ggccucccug gcaucuugga                                                   20


<210>  35505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35505
uuugcucugu cauccccgcg                                                   20


<210>  35506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35506
cagcugaagu gcguuuggag                                                   20


<210>  35507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35507
gcugagaagc ugcgcagcag                                                   20


<210>  35508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35508
uugguuccuu cugcugaguu                                                   20


<210>  35509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35509
uucugcugag uugcucagcg                                                   20


<210>  35510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35510
gcugaguugc ucagcgucuc                                                   20


<210>  35511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35511
uguguggccc uuccugcacu                                                   20


<210>  35512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35512
ugcacuccuc ugauuccuuu                                                   20


<210>  35513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35513
uuuugucuuc ccugguuucu                                                   20


<210>  35514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35514
cugguuucuu gcuuugguuu                                                   20


<210>  35515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35515
ugcuuugguu ucgagucucc                                                   20


<210>  35516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35516
agucuccaca gaacuuuugc                                                   20


<210>  35517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35517
guggagacuc gaaaccaaag                                                   20


<210>  35518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35518
gaagaccugg aagcuuuuuc                                                   20


<210>  35519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35519
gaagagcugc aaaaguucug                                                   20


<210>  35520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35520
aggucuucag aagagcugca                                                   20


<210>  35521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35521
ucuuaauucu caucucauga                                                   20


<210>  35522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35522
caucucauga ccucuuuucc                                                   20


<210>  35523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35523
cuucuuugag agcuagaacu                                                   20


<210>  35524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35524
uugagagcua gaacuuccca                                                   20


<210>  35525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35525
agcucucaaa gaagggaaaa                                                   20


<210>  35526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35526
cauggugaac uucucuuucc                                                   20


<210>  35527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35527
ccaugggaag uucuagcucu                                                   20


<210>  35528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35528
cuuuccagaa uuccaugccu                                                   20


<210>  35529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35529
agaauuccau gccuucuuuu                                                   20


<210>  35530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35530
ggaaagagaa guucaccaug                                                   20


<210>  35531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35531
augccuucuu uucccuccca                                                   20


<210>  35532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35532
uuucccuccc acuuaccugu                                                   20


<210>  35533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35533
cucccacuua ccuguugucc                                                   20


<210>  35534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35534
ccuccaauau gcacagcaau                                                   20


<210>  35535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35535
ucccugggcu cuucaucuca                                                   20


<210>  35536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35536
cugggcucuu caucucacau                                                   20


<210>  35537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35537
ucucacauga caucaccaca                                                   20


<210>  35538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35538
uuggacccuc agugguguca                                                   20


<210>  35539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35539
uuccuuuggc uggccuuagg                                                   20


<210>  35540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35540
uuuggcuggc cuuagggcac                                                   20


<210>  35541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35541
guuucugugu cugucucuug                                                   20


<210>  35542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35542
gugucugucu cuugccugcu                                                   20


<210>  35543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35543
gacuucgccc agagaaagcu                                                   20


<210>  35544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35544
cccagagaaa gcuucucuuu                                                   20


<210>  35545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35545
cugggcgaag ucagaagcag                                                   20


<210>  35546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35546
cuuucacaag gguucuuaga                                                   20


<210>  35547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35547
caaggguucu uagauuuaug                                                   20


<210>  35548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35548
uagauuuaug uucacugagc                                                   20


<210>  35549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35549
cugagcaccu ucuuuucuga                                                   20


<210>  35550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35550
uuucugaggc aguguuuuac                                                   20


<210>  35551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35551
gaggcagugu uuuaccaaua                                                   20


<210>  35552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35552
uagucagucu cgccuuaccu                                                   20


<210>  35553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35553
uguuaugcau gucuuugguc                                                   20


<210>  35554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35554
cugagucugu aaaauagaau                                                   20


<210>  35555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35555
auuuuacaga cucagagaau                                                   20


<210>  35556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35556
uguaauuaaa uuauacagca                                                   20


<210>  35557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35557
aaaggauuuc auguaauuaa                                                   20


<210>  35558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35558
auuuggauac aauaaaauau                                                   20


<210>  35559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35559
cauaggguug guucaauuug                                                   20


<210>  35560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35560
cccagggauc cuaguguaua                                                   20


<210>  35561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35561
uuauacacua ggaucccugg                                                   20


<210>  35562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35562
auuuuuugau auaccacaua                                                   20


<210>  35563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35563
cauuaugaaa gaaaguuagg                                                   20


<210>  35564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35564
uaaugagaaa aaaggguuaa                                                   20


<210>  35565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35565
uucauaauga gaaaaaaggg                                                   20


<210>  35566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35566
uaacuuucuu ucauaaugag                                                   20


<210>  35567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35567
uccaguagcg ccaguguaac                                                   20


<210>  35568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35568
aguagcgcca guguaaccug                                                   20


<210>  35569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35569
gguuacacug gcgcuacugg                                                   20


<210>  35570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35570
aaggcuuuca gguuacacug                                                   20


<210>  35571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35571
gauagcuaua caaaaacuac                                                   20


<210>  35572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35572
uuucagauag cuauacaaaa                                                   20


<210>  35573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35573
uuccaaaaua uuuuuccagu                                                   20


<210>  35574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35574
aaaauauuuu uccagugcug                                                   20


<210>  35575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35575
agugcugaca acaaacacgc                                                   20


<210>  35576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35576
cuccuucacc uucccaaggu                                                   20


<210>  35577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35577
ccuucccaag gucacgcugg                                                   20


<210>  35578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35578
caaggucacg cuggaucuuc                                                   20


<210>  35579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35579
gaacagcacg gaaaaguuug                                                   20


<210>  35580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35580
gaagauccag cgugaccuug                                                   20


<210>  35581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35581
gugcuguucu gaagauccag                                                   20


<210>  35582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35582
ccgcucagcc uuggauguuc                                                   20


<210>  35583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35583
uucucagaua cuagagcugg                                                   20


<210>  35584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35584
cagauacuag agcuggccac                                                   20


<210>  35585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35585
caauguccug caguguggcc                                                   20


<210>  35586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35586
ccuuggguug uggcuggcac                                                   20


<210>  35587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35587
gggcugaguu caucuaggau                                                   20


<210>  35588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35588
ucuaggaugg agccugguuc                                                   20


<210>  35589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35589
ccagggugcc uccgggagac                                                   20


<210>  35590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35590
uggcuaaggc agagucagac                                                   20


<210>  35591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35591
cccuaaacuu cauggcuaag                                                   20


<210>  35592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35592
auuuguauuc uauuuuuguc                                                   20


<210>  35593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35593
auuuuugucu guuaucaugu                                                   20


<210>  35594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35594
aaacuaaacu gggucuaagc                                                   20


<210>  35595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35595
aaauguguuu guagaguccu                                                   20


<210>  35596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35596
uaacuugacc uuuucaagug                                                   20


<210>  35597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35597
aguggaaagg ggcaaaacag                                                   20


<210>  35598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35598
acuugaaaag gucaaguuaa                                                   20


<210>  35599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35599
ucaggcacaa aagagcaagu                                                   20


<210>  35600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35600
cugacacaga uagucucuga                                                   20


<210>  35601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35601
gugagauaag ucagagacua                                                   20


<210>  35602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35602
uuuucuuuuu uuugguggcu                                                   20


<210>  35603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35603
uuuuuuuggu ggcuaauuuc                                                   20


<210>  35604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35604
guuuuauuua uauuuguuua                                                   20


<210>  35605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35605
ggguuacaug ugcagaaugu                                                   20


<210>  35606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35606
gcacauguaa cccagaacuu                                                   20


<210>  35607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35607
ccuaauguua ucccuccccc                                                   20


<210>  35608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35608
ccucccugug cccauguguu                                                   20


<210>  35609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35609
cauuguucaa uuuccacuug                                                   20


<210>  35610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35610
auuuccacuu gugagugaga                                                   20


<210>  35611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35611
acuugugagu gagaacaugc                                                   20


<210>  35612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35612
cacucacaag uggaaauuga                                                   20


<210>  35613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35613
gaucuuguga uaguuugcug                                                   20


<210>  35614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35614
cagcaaacua ucacaagauc                                                   20


<210>  35615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35615
agcaucaucc augugccugc                                                   20


<210>  35616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35616
uguccuuugc aggcacaugg                                                   20


<210>  35617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35617
augguguaua ugugccacau                                                   20


<210>  35618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35618
uaauccaguc uaucauugau                                                   20


<210>  35619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35619
gguugguucc aagucuuugc                                                   20


<210>  35620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35620
aagucuuugc uauugugacu                                                   20


<210>  35621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35621
acgauaaaga cacaugcaca                                                   20


<210>  35622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35622
aguucuagac cuuugaggaa                                                   20


<210>  35623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35623
agaccuuuga ggaaucgcca                                                   20


<210>  35624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35624
ucaaaggucu agaacuagaa                                                   20


<210>  35625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35625
acaauaguug aacuaauuua                                                   20


<210>  35626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35626
acuauugugg aagacagucu                                                   20


<210>  35627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35627
uauuuuucca caaccucucc                                                   20


<210>  35628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35628
acaaccucuc cagcaucugu                                                   20


<210>  35629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35629
ugacuuuuua acgaucgcca                                                   20


<210>  35630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35630
cuaaugacca guggugauga                                                   20


<210>  35631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35631
uaugucuguu ggcugcauaa                                                   20


<210>  35632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35632
uuugcgaagu gucuguucau                                                   20


<210>  35633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35633
caaaagaaga cauuuaugca                                                   20


<210>  35634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35634
uauccuuugu ccauuuuuug                                                   20


<210>  35635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35635
uaaauuuguu uaaguucuuu                                                   20


<210>  35636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35636
uuguagauuc uggauguuaa                                                   20


<210>  35637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35637
ggauguuaau cuuuugucag                                                   20


<210>  35638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35638
guagguugcc uguucacucu                                                   20


<210>  35639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35639
cucugaugau aguuucuuuu                                                   20


<210>  35640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35640
uuugcuaugc agaagcucuu                                                   20


<210>  35641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35641
gcauagcaaa agaaacuauc                                                   20


<210>  35642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35642
ugucuaaaac accaaaagca                                                   20


<210>  35643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35643
ggacauaggc auaggcaaag                                                   20


<210>  35644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35644
ucuaggauuu uuaugguccu                                                   20


<210>  35645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35645
aggauuuuua ugguccuagg                                                   20


<210>  35646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35646
uuauaccuua cacaaaaauc                                                   20


<210>  35647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35647
guuuucugca uguggcuagc                                                   20


<210>  35648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35648
gcauguggcu agccaguuuu                                                   20


<210>  35649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35649
caacaccauu uauuaaauag                                                   20


<210>  35650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35650
cuauuuaaua aaugguguug                                                   20


<210>  35651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35651
ccauugcuua ugugugucag                                                   20


<210>  35652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35652
gaggccucug uucuguucca                                                   20


<210>  35653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35653
guuccauugg ucuauauauc                                                   20


<210>  35654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35654
auuggucuau auaucuguuu                                                   20


<210>  35655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35655
aacuauacua caacacuaca                                                   20


<210>  35656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35656
ucuagcccag gauugucuug                                                   20


<210>  35657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35657
agcccaggau ugucuuggcu                                                   20


<210>  35658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35658
auaugaaguu uaaaauaguu                                                   20


<210>  35659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35659
uauggaacca aaaaagagcc                                                   20


<210>  35660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35660
aauucuguga agaaagucag                                                   20


<210>  35661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35661
gugaagaaag ucagugauag                                                   20


<210>  35662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35662
cagaauugga aaaaacuauu                                                   20


<210>  35663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35663
ucacagaauu ggaaaaaacu                                                   20


<210>  35664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35664
augcuauccc cccaucaagc                                                   20


<210>  35665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35665
cgauauugau ucguccuauc                                                   20


<210>  35666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35666
uccuauccau gaacauggaa                                                   20


<210>  35667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35667
uggauaggac gaaucaauau                                                   20


<210>  35668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35668
auguucaugg auaggacgaa                                                   20


<210>  35669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35669
auuuguuugu guccucucuu                                                   20


<210>  35670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35670
uugagcagug guuuguaguu                                                   20


<210>  35671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35671
ccuugaagag guccuucaca                                                   20


<210>  35672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35672
aggagaacua caaaccacug                                                   20


<210>  35673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35673
caucccuugu aaguugucuu                                                   20


<210>  35674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35674
uagguguuuc auucccuuag                                                   20


<210>  35675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35675
uucccuuagu agcauuugug                                                   20


<210>  35676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35676
cuuaguagca uuugugaaug                                                   20


<210>  35677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35677
caaaugcuac uaagggaaug                                                   20


<210>  35678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35678
cucaugauuu ggcucucugu                                                   20


<210>  35679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35679
uauacaccaa uaacagacaa                                                   20


<210>  35680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35680
gcaaagucuc aggauacaaa                                                   20


<210>  35681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35681
gcucaaaauc uccuuaagcu                                                   20


<210>  35682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35682
aaauauacaa ucaugucauc                                                   20


<210>  35683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35683
ucucuuccua uuugaauacc                                                   20


<210>  35684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35684
uauuugaaua cccuuuauug                                                   20


<210>  35685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35685
aauaggaaga gaggaaguaa                                                   20


<210>  35686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35686
cuugccugau ugcgcuggcc                                                   20


<210>  35687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35687
ggccagcgca aucaggcaag                                                   20


<210>  35688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35688
aauacuaugu ugaauaggag                                                   20


<210>  35689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35689
acauaguauu ggaaguucug                                                   20


<210>  35690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35690
aagggaaugc uuccaguuuu                                                   20


<210>  35691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35691
aaaaccggca caagacaagg                                                   20


<210>  35692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35692
cuucgaaaac cggcacaaga                                                   20


<210>  35693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35693
aguuuuugcc cauucaguau                                                   20


<210>  35694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35694
guaugauauu agcugugggu                                                   20


<210>  35695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35695
aucgauaccu aguuuauuga                                                   20


<210>  35696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35696
ugcuaaaaac ucucaauaaa                                                   20


<210>  35697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35697
acagccuuuc augcuaaaaa                                                   20


<210>  35698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35698
gcaucuguug agauaaucau                                                   20


<210>  35699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35699
guuuauguga uggauuacgu                                                   20


<210>  35700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35700
acauacgcaa aucaauaaac                                                   20


<210>  35701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35701
agggaugaag cugacuugau                                                   20


<210>  35702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35702
ucccuggaau gcaaggcugg                                                   20


<210>  35703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35703
guuugccagu auuuuauuga                                                   20


<210>  35704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35704
caucgauguu caucagggau                                                   20


<210>  35705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35705
ucagggauau uggccuaaaa                                                   20


<210>  35706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35706
cuuuuuuugu ugugucucug                                                   20


<210>  35707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35707
cucuuuuucu auugauugga                                                   20


<210>  35708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35708
auugauugga auaguuucag                                                   20


<210>  35709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35709
aaucaauaga aaaagagaga                                                   20


<210>  35710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35710
gaaggaaugg uaccaucucc                                                   20


<210>  35711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35711
gaaacuauuc caaucaauag                                                   20


<210>  35712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35712
uucugaaacu auuccaauca                                                   20


<210>  35713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35713
accagaggua caaagaggag                                                   20


<210>  35714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35714
gcugugaauc cauccuggac                                                   20


<210>  35715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35715
cagccgaauu cuaccagagg                                                   20


<210>  35716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35716
aaacuugagg caauaguuaa                                                   20


<210>  35717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35717
gagauucagc uuuuuucugg                                                   20


<210>  35718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35718
gcuuuuuucu gguuuagucu                                                   20


<210>  35719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35719
gguuuagucu ugggagggug                                                   20


<210>  35720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35720
uggacacaua cacccuccca                                                   20


<210>  35721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35721
ucuagauuuu cuaguuuauu                                                   20


<210>  35722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35722
agauuuucua guuuauuugg                                                   20


<210>  35723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35723
aguuuauuug gguagagaug                                                   20


<210>  35724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35724
cugaugguag uuuguauuuc                                                   20


<210>  35725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35725
gugggaucgg uggugauauc                                                   20


<210>  35726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35726
ucucucuuuu cuucuuuauu                                                   20


<210>  35727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35727
cucuuuucuu cuuuauuagu                                                   20


<210>  35728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35728
ucuuuauuag ucuugcuagc                                                   20


<210>  35729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35729
uuauuagucu ugcuagcggu                                                   20


<210>  35730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35730
aaaaaccagc accuggauuc                                                   20


<210>  35731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35731
uugauuuuuu uuggaggguu                                                   20


<210>  35732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35732
ugucucuauc uccuucaguu                                                   20


<210>  35733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35733
guucugcucu gaucuuaguu                                                   20


<210>  35734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35734
gcucugaucu uaguuauuuu                                                   20


<210>  35735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35735
gcuagcuuuu gaauuuguuu                                                   20


<210>  35736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35736
aaagcuagca gaagacaaaa                                                   20


<210>  35737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35737
aguucuuuua auugugaugu                                                   20


<210>  35738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35738
uuuaauugug auguuagggu                                                   20


<210>  35739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35739
gcuuucucuu gugggcauuu                                                   20


<210>  35740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35740
cuugugggca uuuagugcua                                                   20


<210>  35741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35741
cucuacacac ugcuuuaaau                                                   20


<210>  35742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35742
gguauguugu gucuucguuc                                                   20


<210>  35743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35743
uucucauugg uuuccaagaa                                                   20


<210>  35744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35744
cauugguuuc caagaaaauu                                                   20


<210>  35745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35745
aagaaaauuu uuauuucugc                                                   20


<210>  35746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35746
uggaaaccaa ugagaacgaa                                                   20


<210>  35747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35747
gccuucauuu cguuauuuac                                                   20


<210>  35748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35748
uuucguuauu uacccaguag                                                   20


<210>  35749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35749
uuauuuaccc aguagucauu                                                   20


<210>  35750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35750
agagcagguu guucaguuuc                                                   20


<210>  35751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35751
guuuccaugu aguugugugg                                                   20


<210>  35752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35752
auguaguugu gugguuuuga                                                   20


<210>  35753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35753
caauccugag uucuaauuug                                                   20


<210>  35754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35754
aauuugauug cacugugguc                                                   20


<210>  35755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35755
guucuuuuac auuugcugag                                                   20


<210>  35756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35756
uuuacauuug cugaggagug                                                   20


<210>  35757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35757
aacuaugugg ucaguuuuag                                                   20


<210>  35758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35758
aaaacugacc acauaguugg                                                   20


<210>  35759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35759
cagcaccaca uugcacuuau                                                   20


<210>  35760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35760
ucucagcacc acauugcacu                                                   20


<210>  35761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35761
guugauuugg ggugcagagu                                                   20


<210>  35762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35762
guagaugucu auuagguccg                                                   20


<210>  35763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35763
aguccuggau auccuuguua                                                   20


<210>  35764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35764
ggcucauuga ucugccuaau                                                   20


<210>  35765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35765
uagagaccua caaagagacu                                                   20


<210>  35766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35766
ugaaucuggg ugcuccugua                                                   20


<210>  35767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35767
ugaagcaagu ucuuagagac                                                   20


<210>  35768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35768
uguugaauug aucccuuuac                                                   20


<210>  35769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35769
acaagaagag cuaacuaucc                                                   20


<210>  35770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35770
uugucuccuu ugaacuuugu                                                   20


<210>  35771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35771
aaggagacaa agaaggccau                                                   20


<210>  35772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35772
auuugcuugu uagaucuucc                                                   20


<210>  35773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35773
uccaucccuu uauuuugagc                                                   20


<210>  35774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35774
ggagacccau cucacaugca                                                   20


<210>  35775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35775
cacauagcaa uauuaaccuu                                                   20


<210>  35776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35776
ucauagcguc aguagucuuu                                                   20


<210>  35777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35777
uagcgucagu agucuuuaca                                                   20


<210>  35778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35778
uuuccauguu uagugcuucc                                                   20


<210>  35779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35779
auguuuagug cuuccuucag                                                   20


<210>  35780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35780
uucaggagcu cuuguaaggc                                                   20


<210>  35781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35781
ggagcucuug uaaggcaggc                                                   20


<210>  35782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35782
cguucacuua ugaagcuuag                                                   20


<210>  35783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35783
cuuaugaagc uuaguuuggc                                                   20


<210>  35784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35784
uaagugaacg agaaauaaaa                                                   20


<210>  35785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35785
uauccagcca aacuaagcuu                                                   20


<210>  35786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35786
ggguugaaaa uacuuuuuuu                                                   20


<210>  35787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35787
acccagaauu ucauauccag                                                   20


<210>  35788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35788
uuaaaaaaag uauuuucaac                                                   20


<210>  35789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35789
acauucuuua aaaaaaguau                                                   20


<210>  35790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35790
ggcuuguagg auuucugcag                                                   20


<210>  35791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35791
gcagagagau cugcuguuag                                                   20


<210>  35792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35792
cuuugugggu aacccgaccu                                                   20


<210>  35793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35793
cucuggcugc ccuuuccuuc                                                   20


<210>  35794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35794
uucauuucaa ucuuggugga                                                   20


<210>  35795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35795
uuucaaucuu gguggaucug                                                   20


<210>  35796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35796
aucuuggugg aucugaugau                                                   20


<210>  35797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35797
cgaggaguau cuuuguggug                                                   20


<210>  35798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35798
cuguauuucc ugaauuugaa                                                   20


<210>  35799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35799
ugaauuugaa uguuggucug                                                   20


<210>  35800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35800
ggaaauacag agaacaccac                                                   20


<210>  35801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35801
aauucaggaa auacagagaa                                                   20


<210>  35802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35802
ccaaccuagc aaggcagacc                                                   20


<210>  35803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35803
ccuggauaau auccugaaga                                                   20


<210>  35804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35804
ggauauuauc caggagaacu                                                   20


<210>  35805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35805
aacuugguuc uauucucccc                                                   20


<210>  35806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35806
auucucccca ucacuuucag                                                   20


<210>  35807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35807
ccccaucacu uucagguaca                                                   20


<210>  35808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35808
gguacaccaa ucaaacguag                                                   20


<210>  35809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35809
cauaguccca uauuucuugg                                                   20


<210>  35810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35810
uggaggcuug guucauuucu                                                   20


<210>  35811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35811
uuucuuuuca cucuuuuuuc                                                   20


<210>  35812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35812
uuucacucuu uuuucucuaa                                                   20


<210>  35813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35813
cucuuuuuuc ucuaaucuug                                                   20


<210>  35814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35814
cuaaucuugu cuucucgcuu                                                   20


<210>  35815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35815
cgcuuuauuu cauuaauuug                                                   20


<210>  35816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35816
uuaauuugau cuucaaucac                                                   20


<210>  35817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35817
aucacugaua uccuuucuuc                                                   20


<210>  35818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35818
ucugcuugau ugaaucggcu                                                   20


<210>  35819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35819
gcuugauuga aucggcuguc                                                   20


<210>  35820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35820
aucaagcaga agaaaggaua                                                   20


<210>  35821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35821
acagccgauu caaucaagca                                                   20


<210>  35822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35822
caaaauucuc guucuguggu                                                   20


<210>  35823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35823
cguucugugg uuuuuagcuc                                                   20


<210>  35824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35824
gugguuuuua gcuccaucag                                                   20


<210>  35825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35825
cuacacuggu uauucuagcc                                                   20


<210>  35826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35826
agccauuagu cuaacauuuu                                                   20


<210>  35827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35827
agguuuuuag cuuccuugug                                                   20


<210>  35828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35828
uugugauggg uuagaacaug                                                   20


<210>  35829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35829
aacccaucac aaggaagcua                                                   20


<210>  35830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35830
ccgagcuaaa ggagcauguu                                                   20


<210>  35831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35831
gaagccuacu ucugucaauu                                                   20


<210>  35832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35832
gaaggucggu aauaacaaac                                                   20


<210>  35833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35833
gucaauucau caaacucauu                                                   20


<210>  35834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35834
ucaaacucau ucuccaucca                                                   20


<210>  35835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35835
ccauccaguu uuguucccuu                                                   20


<210>  35836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35836
cuugcuggug aggaguugug                                                   20


<210>  35837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35837
ccuccaaagg aucacaacuc                                                   20


<210>  35838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35838
gguuuuugga auuuucagcc                                                   20


<210>  35839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35839
aaaaaccaga acaccucuuc                                                   20


<210>  35840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35840
gccuuucugc uaugguuucu                                                   20


<210>  35841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35841
gcuaugguuu cuccccauca                                                   20


<210>  35842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35842
ccccaucauu gugguuuuau                                                   20


<210>  35843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35843
uuucuguuug uuaguuuucc                                                   20


<210>  35844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35844
guuuguuagu uuuccuucua                                                   20


<210>  35845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35845
uucuaacaga caggccccuc                                                   20


<210>  35846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35846
aacagacagg ccccucagcu                                                   20


<210>  35847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35847
gcagccucug cuggugaugc                                                   20


<210>  35848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35848
ucuggaaaca ucgucccaga                                                   20


<210>  35849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35849
agaggaagga ucaggcagca                                                   20


<210>  35850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35850
ugcucuggga cgauguuucc                                                   20


<210>  35851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35851
uuaucggagc uugaaugccg                                                   20


<210>  35852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35852
agcuccgaua augaacagac                                                   20


<210>  35853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35853
cccgguacgg cauucaagcu                                                   20


<210>  35854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35854
gagcugucag gcacguaugu                                                   20


<210>  35855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35855
ccagauuuaa acauacgugc                                                   20


<210>  35856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35856
gaugugcccu ucccccagag                                                   20


<210>  35857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35857
cccagaggug gaaucuagag                                                   20


<210>  35858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35858
accucugggg gaagggcaca                                                   20


<210>  35859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35859
agcuucccug cugcuuuguu                                                   20


<210>  35860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35860
cugcugcuuu guuuacacug                                                   20


<210>  35861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35861
augcucacag uguaaacaaa                                                   20


<210>  35862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35862
gagugcugcg cuagcaguga                                                   20


<210>  35863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35863
cuccugugcc uggcucagcg                                                   20


<210>  35864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35864
caaccagcag accaggagau                                                   20


<210>  35865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35865
cacagucuuc acaaccagca                                                   20


<210>  35866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35866
gguacaguca cucauggcuu                                                   20


<210>  35867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35867
uuuggcuugg aaagggaagu                                                   20


<210>  35868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35868
aagccaaagg aagccaugag                                                   20


<210>  35869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35869
cuuuccaagc caaaggaagc                                                   20


<210>  35870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35870
caggugaggc aacaccccgc                                                   20


<210>  35871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35871
gcuugcccuc cgugggcugc                                                   20


<210>  35872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35872
ucucacuggg acuugcugga                                                   20


<210>  35873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35873
aacugaggua ccuaguucau                                                   20


<210>  35874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35874
gcauuuccaa cugagguacc                                                   20


<210>  35875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35875
gugucgaucu cacugggagc                                                   20


<210>  35876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35876
uauucggcca uuuuggaagc                                                   20


<210>  35877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35877
gccauuuugg aagcaucccu                                                   20


<210>  35878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35878
aaaauggccg aauaggaaca                                                   20


<210>  35879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35879
agcgauucuc cuaccucagc                                                   20


<210>  35880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35880
ccuaccucag ccuccggagu                                                   20


<210>  35881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35881
ccacauuggc caggcuaguc                                                   20


<210>  35882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35882
agacuagccu ggccaaugug                                                   20


<210>  35883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35883
gaucucccuc ucuuugcccu                                                   20


<210>  35884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35884
auuuugcuaa aauguguuau                                                   20


<210>  35885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35885
aauuuaaaac auauaguauu                                                   20


<210>  35886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35886
guauaaucuc acguucaaau                                                   20


<210>  35887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35887
uuaaauagua agauuuucuu                                                   20


<210>  35888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35888
uuuuuguaug uggguuuuuu                                                   20


<210>  35889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35889
auauaugaca gucauaauaa                                                   20


<210>  35890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35890
guuacaguca gugaauguau                                                   20


<210>  35891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35891
cugacuguaa cugaaaaaca                                                   20


<210>  35892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35892
uuaaauugug acuuauuaau                                                   20


<210>  35893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35893
ugaaaucagc cauaugguug                                                   20


<210>  35894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35894
agaauauaaa gaucaacuaa                                                   20


<210>  35895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35895
gagaugagcu uauuaucuuu                                                   20


<210>  35896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35896
uaugccaaau guaaaaauuu                                                   20


<210>  35897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35897
cuggccugug ucuuuacagu                                                   20


<210>  35898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35898
aaguucaucu uuuuugcugu                                                   20


<210>  35899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35899
ucuuuuuugc uguuucaaga                                                   20


<210>  35900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35900
agacagaggc ccauuuuagc                                                   20


<210>  35901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35901
cgcauauccu uuuguuugua                                                   20


<210>  35902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35902
aaaguacaaa caaaaggaua                                                   20


<210>  35903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35903
acccuacaua ucccccucua                                                   20


<210>  35904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35904
cagguucuug uuugcacuug                                                   20


<210>  35905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35905
uguuugcacu uggccccuga                                                   20


<210>  35906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35906
ucaaaacagu caggggccaa                                                   20


<210>  35907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35907
gaucucuuuc ugccacacag                                                   20


<210>  35908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35908
gccacacagc aguucugagg                                                   20


<210>  35909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35909
gaggcagcug gaaagauauc                                                   20


<210>  35910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35910
agcugccuca gaacugcugu                                                   20


<210>  35911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35911
ccuaagcaag gucacagaua                                                   20


<210>  35912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35912
ucagacuucu gugaguuuac                                                   20


<210>  35913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35913
gacuucugug aguuuaccua                                                   20


<210>  35914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35914
gugaguuuac cuaguuccag                                                   20


<210>  35915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35915
aggauuuaaa ggcacagaga                                                   20


<210>  35916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35916
aaagucucug ugccuuuaaa                                                   20


<210>  35917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35917
auuuuaauuc uaaagucucu                                                   20


<210>  35918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35918
uuuucuaaau agcaacacua                                                   20


<210>  35919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35919
aaauagcaac acuaggaaua                                                   20


<210>  35920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35920
uaguguugcu auuuagaaaa                                                   20


<210>  35921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35921
acauucuuga cagguaaugu                                                   20


<210>  35922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35922
ugacagguaa uguuuuuucu                                                   20


<210>  35923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35923
ugucuucuaa uccuuauuua                                                   20


<210>  35924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35924
aauccuuauu uauuccauac                                                   20


<210>  35925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35925
auacucauuu uuauacauaa                                                   20


<210>  35926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35926
auuauguaua aaaaugagua                                                   20


<210>  35927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35927
uuugcauuau auuauagacg                                                   20


<210>  35928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35928
uguaacuccu uacuguucca                                                   20


<210>  35929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35929
auuuuauaug uuuugucugg                                                   20


<210>  35930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35930
cgguuugcag auaaagucuu                                                   20


<210>  35931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35931
uuuuguagag acaguuuccc                                                   20


<210>  35932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35932
ugugccuggg uuuauugagg                                                   20


<210>  35933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35933
uaguauuuuu aaaguuugga                                                   20


<210>  35934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35934
aaacuuuaaa aauacuauga                                                   20


<210>  35935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35935
uucuuucuuu cuuucuuuuu                                                   20


<210>  35936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35936
uucuuucuuu cuuuuuuuuu                                                   20


<210>  35937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35937
uucuuucuuu uuuuuuuuuu                                                   20


<210>  35938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35938
uucuuuuuuu uuuuuuugag                                                   20


<210>  35939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35939
uuuuuuuuuu uuugagacag                                                   20


<210>  35940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35940
cgccauucuc cugccucagc                                                   20


<210>  35941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35941
ccugccucag ccuccugagu                                                   20


<210>  35942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35942
cuguguuagc caggaugguc                                                   20


<210>  35943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35943
ucaaagauuu uuuuucugcc                                                   20


<210>  35944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35944
aagauuuuuu uucugcccug                                                   20


<210>  35945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35945
gcccugccuc ccuccuuuuu                                                   20


<210>  35946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35946
cucucuuaaa ggggcuguga                                                   20


<210>  35947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35947
ugaaugauug cuuaguguug                                                   20


<210>  35948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35948
ggaaaucaca gccccuuuaa                                                   20


<210>  35949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35949
guguuugauu guuuuaugug                                                   20


<210>  35950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35950
guuuuguaua guuucuauua                                                   20


<210>  35951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35951
auuauugugu uuucaaguuc                                                   20


<210>  35952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35952
aguucucuga ucuuuucuuc                                                   20


<210>  35953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35953
cugaucuuuu cuucuacagu                                                   20


<210>  35954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35954
ucuacagugu cuacucuguu                                                   20


<210>  35955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35955
acagugucua cucuguuguu                                                   20


<210>  35956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35956
aaaacaaaaa aaaaaauacg                                                   20


<210>  35957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35957
ucugccucag ccucccgagu                                                   20


<210>  35958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35958
gccucagccu cccgaguagc                                                   20


<210>  35959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35959
ccauguuggc caaacuggcc                                                   20


<210>  35960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35960
aggccaguuu ggccaacaug                                                   20


<210>  35961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35961
uccgccucgg ucucccaaag                                                   20


<210>  35962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35962
guguauauca cuaauuuugu                                                   20


<210>  35963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35963
agagauaaaa acaaaauuag                                                   20


<210>  35964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35964
guuuagcuuu gugaacacaa                                                   20


<210>  35965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35965
caaagcuaaa cagaaacaca                                                   20


<210>  35966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35966
cugcuaguuc uaagaucuuc                                                   20


<210>  35967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35967
aagaucuucu aauaacuucc                                                   20


<210>  35968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35968
aauaacuucc caguucuugg                                                   20


<210>  35969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35969
caguucuugg uguuucucau                                                   20


<210>  35970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35970
ugguguuucu cauugguuga                                                   20


<210>  35971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35971
cauugguuga uugauacucc                                                   20


<210>  35972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35972
ugccucuuug uauggcugcc                                                   20


<210>  35973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35973
caagguuggg cauccaauaa                                                   20


<210>  35974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35974
cauagaucuu cuugagcuuu                                                   20


<210>  35975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35975
ugagcuuugu ucugagguua                                                   20


<210>  35976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35976
gagguuaguu gaguuacaua                                                   20


<210>  35977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35977
ucuuuaggaa uaauuaggua                                                   20


<210>  35978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35978
uaaagaggaa uaauuagucc                                                   20


<210>  35979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35979
uuagguagag uacucaggau                                                   20


<210>  35980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35980
gguucauuag guagaguacu                                                   20


<210>  35981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35981
aguccgccug cugagaacag                                                   20


<210>  35982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35982
cagcaggcgg acuggaaaac                                                   20


<210>  35983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35983
agcccugugu gagcgcugag                                                   20


<210>  35984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35984
aauccuuucc aaugcuucuu                                                   20


<210>  35985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35985
aaugcuucuu ucccuggccu                                                   20


<210>  35986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35986
uucccuggcc ucagggaguu                                                   20


<210>  35987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35987
cuggccucag ggaguuuucu                                                   20


<210>  35988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35988
cacacacaua ucucugcuga                                                   20


<210>  35989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35989
ccagaucucc agagcucucu                                                   20


<210>  35990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35990
cuucucuggu gcucugucuu                                                   20


<210>  35991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35991
cuggugcucu gucuuaugaa                                                   20


<210>  35992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35992
uaagacagag caccagagaa                                                   20


<210>  35993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35993
cagcaccucu ucaauucaga                                                   20


<210>  35994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35994
auucagaggg uugccugucc                                                   20


<210>  35995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35995
gaggguugcc ugucccuccu                                                   20


<210>  35996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35996
uaggcugugg cacaaggagg                                                   20


<210>  35997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35997
uugcucaugu ccagugucuu                                                   20


<210>  35998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35998
acuacugagc acaaugaggg                                                   20


<210>  35999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  35999
cugguacuug gggagcucuu                                                   20


<210>  36000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36000
agagcucccc aaguaccagg                                                   20


<210>  36001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36001
ggccuuucaa gagcucccca                                                   20


<210>  36002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36002
caccuuuucc agggcuucag                                                   20


<210>  36003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36003
agggcuucag uuucuggugc                                                   20


<210>  36004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36004
guuucuggug cacaucaagc                                                   20


<210>  36005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36005
ggugcacauc aagcauucca                                                   20


<210>  36006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36006
auacacauuu guuaaagucc                                                   20


<210>  36007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36007
cagguucuau uuguaauuuu                                                   20


<210>  36008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36008
auuuguaauu uuuucaguua                                                   20


<210>  36009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36009
guuaacaugu auuggguauc                                                   20


<210>  36010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36010
auucugacaa gaacaaccuu                                                   20


<210>  36011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36011
gacaagaaca accuuaaaca                                                   20


<210>  36012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36012
ugucagaauu gaauuuguca                                                   20


<210>  36013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36013
aaguguuuaa gguuguucuu                                                   20


<210>  36014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36014
gauaugcuca aaguauauuc                                                   20


<210>  36015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36015
aauacucaag ggccacacau                                                   20


<210>  36016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36016
uguugguuuc aaauacucaa                                                   20


<210>  36017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36017
gucuaauugg uguuggcuuu                                                   20


<210>  36018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36018
aucagcugcu aaaagccaac                                                   20


<210>  36019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36019
ugauuagcca ggcaguggug                                                   20


<210>  36020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36020
ccacugccug gcuaaucacg                                                   20


<210>  36021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36021
gaaugccuag guaucuaggc                                                   20


<210>  36022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36022
gaaugcacag ccuguuucac                                                   20


<210>  36023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36023
gaaugguggc gcucuuugag                                                   20


<210>  36024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36024
gaaugccuag auaccuaggc                                                   20


<210>  36025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36025
ucuuucuuga uucuuuuuuu                                                   20


<210>  36026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36026
uucuugauuc uuuuuuuuuu                                                   20


<210>  36027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36027
ugauucuuuu uuuuuuuuuu                                                   20


<210>  36028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36028
uuuuuuuuuu uuuuugagau                                                   20


<210>  36029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36029
cucuuguugc ccagguaaca                                                   20


<210>  36030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36030
agcgauucuc cugccucagc                                                   20


<210>  36031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36031
ccugccucag ccucucaagu                                                   20


<210>  36032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36032
cuauauuggu caggcugguc                                                   20


<210>  36033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36033
agaccagccu gaccaauaua                                                   20


<210>  36034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36034
ugauucuuga aaaggacauu                                                   20


<210>  36035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36035
ugaaaaggac auugggugcu                                                   20


<210>  36036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36036
agaaucaaga aggggcuggg                                                   20


<210>  36037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36037
cacaagcauu uuuaucaaca                                                   20


<210>  36038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36038
aggacugauu ugugguaaau                                                   20


<210>  36039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36039
cugaacauau ucaggggcuc                                                   20


<210>  36040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36040
gugaacacaa cuaugauaca                                                   20


<210>  36041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36041
ggggcucuac agaugcaggg                                                   20


<210>  36042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36042
gaauuccugc ccugcgaaca                                                   20


<210>  36043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36043
gaagugugca aagcagcuaa                                                   20


<210>  36044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36044
ugcccugcga acaggacugg                                                   20


<210>  36045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36045
cagggcagga auucagaagu                                                   20


<210>  36046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36046
auaaacuguu aucaaguacc                                                   20


<210>  36047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36047
cucauuaauu caauaaacug                                                   20


<210>  36048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36048
uucacucauu aauucaauaa                                                   20


<210>  36049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36049
ugcauuuaug uaucuguuca                                                   20


<210>  36050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36050
uucaugcauu uauguaucug                                                   20


<210>  36051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36051
agacuuuuua cugacuguuc                                                   20


<210>  36052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36052
aaauaagaaa uugaaaacuu                                                   20


<210>  36053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36053
uauuuugaac agucaguaaa                                                   20


<210>  36054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36054
auuucuuauu uugaacaguc                                                   20


<210>  36055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36055
ucugauuuuc cucuacuauu                                                   20


<210>  36056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36056
ucuacuauuu acacaauuua                                                   20


<210>  36057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36057
auuuaaauug uguaaauagu                                                   20


<210>  36058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36058
auuucugucu aggauucgua                                                   20


<210>  36059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36059
gucuaggauu cguacaauaa                                                   20


<210>  36060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36060
uacaauaacg ggucaucucu                                                   20


<210>  36061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36061
acaguguguu gaagagaucc                                                   20


<210>  36062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36062
acacacugua gaaagacaag                                                   20


<210>  36063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36063
gguauccuag gaucucuuca                                                   20


<210>  36064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36064
cgacuaaagc aggauuucag                                                   20


<210>  36065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36065
acaaguaaga gcuucauucu                                                   20


<210>  36066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36066
uucuuuuccu cuucuguuaa                                                   20


<210>  36067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36067
uuuccucuuc uguuaagacg                                                   20


<210>  36068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36068
ucuucuguua agacguucgg                                                   20


<210>  36069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36069
guuaagacgu ucggguauga                                                   20


<210>  36070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36070
gguaugacag caaaacgcug                                                   20


<210>  36071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36071
cuucacuccc caggaggacg                                                   20


<210>  36072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36072
cuccccagga ggacgagguc                                                   20


<210>  36073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36073
gguguccucu gcccuccaca                                                   20


<210>  36074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36074
agucccucgg aguuucuguu                                                   20


<210>  36075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36075
guuuagaaug cucaaucuca                                                   20


<210>  36076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36076
aaacagaaac uccgagggac                                                   20


<210>  36077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36077
aaaugagauu gagcauucua                                                   20


<210>  36078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36078
uugcaauucu aaaugagauu                                                   20


<210>  36079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36079
uacaauaucu caugagguau                                                   20


<210>  36080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36080
caggaagaau uucacgcugu                                                   20


<210>  36081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36081
ugugaaucac uauuaauacc                                                   20


<210>  36082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36082
uccugugaau cacuauuaau                                                   20


<210>  36083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36083
cgcugugagu cuuugcuaac                                                   20


<210>  36084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36084
uaaaaguguu guucacgcca                                                   20


<210>  36085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36085
cgccacauug uugaugccuc                                                   20


<210>  36086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36086
cuguaguugu ugaagacucu                                                   20


<210>  36087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36087
acaacuacag ugaaaaaaau                                                   20


<210>  36088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36088
aaccccagca agucacaagg                                                   20


<210>  36089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36089
uggccccgua cacccacuuc                                                   20


<210>  36090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36090
cccaggcccu cgcugacgcc                                                   20


<210>  36091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36091
ucaggcuggc gucagcgagg                                                   20


<210>  36092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36092
ccugcuccgc cugcaccaug                                                   20


<210>  36093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36093
ugccacaacu guuaccccga                                                   20


<210>  36094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36094
accaacgaca gcauucuugc                                                   20


<210>  36095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36095
ugcuuccacc aacgacagca                                                   20


<210>  36096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36096
ugcuugcucu uucgugcuuc                                                   20


<210>  36097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36097
uuuacaaagu auuuccugcu                                                   20


<210>  36098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36098
uuuuuauucu uuuacaaagu                                                   20


<210>  36099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36099
cuaacauuuu ucguuuuuau                                                   20


<210>  36100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36100
aauagucugc uguauucaga                                                   20


<210>  36101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36101
gagaacucua ggagauauau                                                   20


<210>  36102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36102
cugaauacag cagacuauua                                                   20


<210>  36103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36103
aagaagugug uggccaguga                                                   20


<210>  36104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36104
uggaaggccg ggcuaugccu                                                   20


<210>  36105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36105
uccuccucua cccccaccuc                                                   20


<210>  36106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36106
cagcccacuc aguguuccuc                                                   20


<210>  36107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36107
gguuugcuga cacacuuugg                                                   20


<210>  36108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36108
uaaugucccc acccauucaa                                                   20


<210>  36109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36109
aagcacagga ccuguagagu                                                   20


<210>  36110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36110
ggccuguaac aaggaugaaa                                                   20


<210>  36111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36111
uccuuguuac aggccugaaa                                                   20


<210>  36112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36112
uucauccuug uuacaggccu                                                   20


<210>  36113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36113
uagcagcaca guagugcugg                                                   20


<210>  36114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36114
gaggugugug aaggccauag                                                   20


<210>  36115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36115
cacaccucug aacaccagca                                                   20


<210>  36116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36116
auggccuuca cacaccucug                                                   20


<210>  36117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36117
agucauaaag cugacaaaac                                                   20


<210>  36118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36118
cuuaaauuug uuuuuuuuuu                                                   20


<210>  36119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36119
ugccauucuc cugccucagc                                                   20


<210>  36120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36120
ccugccucag ccucccgagu                                                   20


<210>  36121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36121
ccauguuagc caggaugguc                                                   20


<210>  36122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36122
cuuaaauuua uguuuguguu                                                   20


<210>  36123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36123
uaaauugccu uaaguaugaa                                                   20


<210>  36124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36124
uacuuaaggc aauuuaagaa                                                   20


<210>  36125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36125
auuauugcua cuauacagau                                                   20


<210>  36126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36126
uuuuauaaau uuagcgauua                                                   20


<210>  36127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36127
uugacuccug acucuagugu                                                   20


<210>  36128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36128
aggcuguaug uuagugaugu                                                   20


<210>  36129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36129
ggaguaaguc uguuucaaug                                                   20


<210>  36130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36130
augcuuucug uaaccauuug                                                   20


<210>  36131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36131
guaaccauuu gggguauuaa                                                   20


<210>  36132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36132
uauauguuuc uuagaaggga                                                   20


<210>  36133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36133
uagaagggau aucauugaug                                                   20


<210>  36134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36134
aagaaacaua uaugaaauua                                                   20


<210>  36135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36135
ucuaaauuac ugaucuuuua                                                   20


<210>  36136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36136
aaauuacuga ucuuuuaaau                                                   20


<210>  36137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36137
ccuuucucuc aaaucucacu                                                   20


<210>  36138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36138
cucaaaucuc acuuaagacu                                                   20


<210>  36139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36139
uguagcagaa aaaagcucag                                                   20


<210>  36140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36140
gcuacaggaa acugacuacu                                                   20


<210>  36141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36141
gcgagugagg agacuugaug                                                   20


<210>  36142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36142
gauaaugaca cucuauuuag                                                   20


<210>  36143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36143
aguuguuucu caaucugaca                                                   20


<210>  36144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36144
caaucugaca cguucugauc                                                   20


<210>  36145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36145
gaucguguga augugaaauu                                                   20


<210>  36146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36146
cacgaucaga acgugucaga                                                   20


<210>  36147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36147
cauucacacg aucagaacgu                                                   20


<210>  36148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36148
cauucucugc uucccuuuua                                                   20


<210>  36149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36149
cugcuucccu uuuauuccca                                                   20


<210>  36150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36150
cuuuuauucc cauuuggcag                                                   20


<210>  36151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36151
cauuuggcag augguuugau                                                   20


<210>  36152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36152
ggaggacauc aaaccaucug                                                   20


<210>  36153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36153
acuggguaga cacuuucugg                                                   20


<210>  36154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36154
uugugacacu cgugagguuu                                                   20


<210>  36155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36155
caugccacaa acggcaccau                                                   20


<210>  36156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36156
ucucuagcac ugacacgccu                                                   20


<210>  36157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36157
agguauuuug cuugaagcuu                                                   20


<210>  36158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36158
agcaaaauac cuggaaaguc                                                   20


<210>  36159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36159
acuaaaagcu ucaagcaaaa                                                   20


<210>  36160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36160
uucuuucuuu uuuucuuuuu                                                   20


<210>  36161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36161
uucuuuuuuu cuuuuuuaua                                                   20


<210>  36162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36162
uuuuuucuuu uuuauagaau                                                   20


<210>  36163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36163
uuuuuauaga augcuauuca                                                   20


<210>  36164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36164
auaaaaaaga aaaaaagaaa                                                   20


<210>  36165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36165
uaaucacauu cguuuguuug                                                   20


<210>  36166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36166
uuuguuugaa ccucuuguua                                                   20


<210>  36167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36167
aacaaacgaa ugugauuaug                                                   20


<210>  36168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36168
guaacugcac acauguugua                                                   20


<210>  36169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36169
guuacggguu aauuacuguc                                                   20


<210>  36170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36170
ggauucagau cagguuuguc                                                   20


<210>  36171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36171
gaucagguuu gucacuuuua                                                   20


<210>  36172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36172
uccaucauac cuguuccuaa                                                   20


<210>  36173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36173
uaauuuagua caaauuaccc                                                   20


<210>  36174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36174
gugucuuuua ggguaauuug                                                   20


<210>  36175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36175
uuaaaguaga uuucaguguc                                                   20


<210>  36176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36176
cucaucaguu gcugcugcuu                                                   20


<210>  36177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36177
ugcaccuagc uggugcagaa                                                   20


<210>  36178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36178
gcaccagcua ggugcaugaa                                                   20


<210>  36179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36179
aaagguuugu cccauccacu                                                   20


<210>  36180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36180
aacuuauuuu ggaggggagg                                                   20


<210>  36181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36181
ccaaacaaua aaucuuaauu                                                   20


<210>  36182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36182
agcuaucuaa cagguucacu                                                   20


<210>  36183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36183
cuuaccucuu uaaaaaggaa                                                   20


<210>  36184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36184
uuuuuaaaga gguaagugaa                                                   20


<210>  36185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36185
auuccuuuuu aaagagguaa                                                   20


<210>  36186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36186
ccucuugacu gcauuaccuu                                                   20


<210>  36187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36187
uccuauaguu gcugugggca                                                   20


<210>  36188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36188
ggcuaguccu gucccuucau                                                   20


<210>  36189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36189
ugaugcacau uuuccucaag                                                   20


<210>  36190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36190
ucaagauucg ucccaguuaa                                                   20


<210>  36191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36191
ucccaguuaa aucacugcag                                                   20


<210>  36192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36192
ucugcaguga uuuaacuggg                                                   20


<210>  36193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36193
ucgucaaaau uuaacuguca                                                   20


<210>  36194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36194
uauguggggu aggaauauuu                                                   20


<210>  36195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36195
uaccccacau aagaaaguag                                                   20


<210>  36196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36196
aacucacaaa uauuccuacc                                                   20


<210>  36197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36197
cuauuuccuu cuagacguaa                                                   20


<210>  36198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36198
uucuagacgu aaaucuguua                                                   20


<210>  36199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36199
agacguaaau cuguuaaucc                                                   20


<210>  36200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36200
ggugaguaac agugcugaca                                                   20


<210>  36201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36201
cuaggagaac ugagggcacu                                                   20


<210>  36202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36202
ccuagggaaa cagacccuuu                                                   20


<210>  36203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36203
acagugggua uugggguggu                                                   20


<210>  36204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36204
cgccauucuc cugccucagc                                                   20


<210>  36205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36205
ccugccucag ccucccgagu                                                   20


<210>  36206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36206
cuguguuagc caggaugguc                                                   20


<210>  36207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36207
uuaaaagcag accccaggcc                                                   20


<210>  36208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36208
ucuuucuuuc acaaaaccug                                                   20


<210>  36209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36209
uucacaaaac cuguccgaag                                                   20


<210>  36210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36210
caaaaccugu ccgaagaaaa                                                   20


<210>  36211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36211
gacagguuuu gugaaagaaa                                                   20


<210>  36212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36212
ucggacaggu uuugugaaag                                                   20


<210>  36213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36213
ugaggagagc aauggcccau                                                   20


<210>  36214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36214
caaugacuau uuccugagga                                                   20


<210>  36215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36215
uuuccuuucc uuugacacua                                                   20


<210>  36216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36216
uuuccuuuga cacuaggagg                                                   20


<210>  36217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36217
uuugacacua ggaggcugac                                                   20


<210>  36218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36218
ccccagucag ccuccuagug                                                   20


<210>  36219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36219
cuugggguac ccgugccccc                                                   20


<210>  36220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36220
auucuaguaa gaacaaagac                                                   20


<210>  36221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36221
aguaagaaca aagacugcuc                                                   20


<210>  36222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36222
uacuagaaug gaacaaauca                                                   20


<210>  36223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36223
uguuuguucu gauugccuuu                                                   20


<210>  36224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36224
gauugccuuu caucaaccgg                                                   20


<210>  36225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36225
ucaaccgguc cccuuucucc                                                   20


<210>  36226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36226
cccaguucuu aagauucagu                                                   20


<210>  36227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36227
uaagauucag uacagugaca                                                   20


<210>  36228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36228
guacagugac aguuuuauga                                                   20


<210>  36229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36229
uaaaacuguc acuguacuga                                                   20


<210>  36230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36230
uguucauaaa acugucacug                                                   20


<210>  36231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36231
auucuuguuc auaaaacugu                                                   20


<210>  36232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36232
aguguucuau ucuuguucau                                                   20


<210>  36233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36233
augguuuguc uguucuagug                                                   20


<210>  36234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36234
gcccagaggc ucugagaaaa                                                   20


<210>  36235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36235
cagagccucu gggcagaaug                                                   20


<210>  36236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36236
auggauaaag cauggagcau                                                   20


<210>  36237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36237
caaccugacg gggagcuucc                                                   20


<210>  36238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36238
cugcagcugu cagcuuuccc                                                   20


<210>  36239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36239
ucccccaacc aucugagagg                                                   20


<210>  36240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36240
gggaaucugu gccacccuau                                                   20


<210>  36241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36241
cugaaacugg uuuaguaaua                                                   20


<210>  36242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36242
cguuaauggc agauagggug                                                   20


<210>  36243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36243
aagagacauc agacaauacc                                                   20


<210>  36244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36244
aaugagauuu caccucaggg                                                   20


<210>  36245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36245
ccucagggua uaguaaaguu                                                   20


<210>  36246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36246
uggauguguu cugcaauuau                                                   20


<210>  36247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36247
gcaauuaucu aggcugauuu                                                   20


<210>  36248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36248
gaauagaguu augcuuauag                                                   20


<210>  36249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36249
gaaaucagcc uagauaauug                                                   20


<210>  36250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36250
ugacagcuga uaaauuugac                                                   20


<210>  36251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36251
uccugcuuau cugcauaaau                                                   20


<210>  36252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36252
uuuccuccug cuuaucugca                                                   20


<210>  36253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36253
caucaauaau aggauuaaaa                                                   20


<210>  36254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36254
uuccuguagg uguuuauugg                                                   20


<210>  36255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36255
uguagguguu uauuggcuuu                                                   20


<210>  36256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36256
auacaaagcc aauaaacacc                                                   20


<210>  36257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36257
aacuguuuca auacaaagcc                                                   20


<210>  36258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36258
auguauucaa acuguuucaa                                                   20


<210>  36259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36259
gguaauagca uuuuauuauu                                                   20


<210>  36260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36260
ucuucuugug uacuuacaug                                                   20


<210>  36261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36261
ucuuguguac uuacauguaa                                                   20


<210>  36262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36262
uguguacuua cauguaauuu                                                   20


<210>  36263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36263
cuuaauaacc uaaauuacau                                                   20


<210>  36264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36264
uuaaauggaa aucugacuaa                                                   20


<210>  36265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36265
auuuaaagaa aacagcaaaa                                                   20


<210>  36266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36266
cuuaaaaauu aauguauauc                                                   20


<210>  36267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36267
aaacaagucu ugagauauac                                                   20


<210>  36268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36268
gauacauaac uacuuccaaa                                                   20


<210>  36269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36269
auauguuguc aguauucauu                                                   20


<210>  36270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36270
uugcacauuu caaagcauuu                                                   20


<210>  36271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36271
aagcauuuaa uuguguugac                                                   20


<210>  36272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36272
accaucuguc aacacaauua                                                   20


<210>  36273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36273
uuccaccauc ugucaacaca                                                   20


<210>  36274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36274
uagagaaagc aguuuuauau                                                   20


<210>  36275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36275
cuaagaagau uuaaaaacua                                                   20


<210>  36276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36276
cugcagcuuu uucuugcuag                                                   20


<210>  36277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36277
ugcuagaugu ugagguuuua                                                   20


<210>  36278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36278
ugcuagucca uuacagguuu                                                   20


<210>  36279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36279
uuuaguaccu aaaaugcuua                                                   20


<210>  36280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36280
uaauuacaau guuuauuaag                                                   20


<210>  36281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36281
gcacuaaauu uuccuaauua                                                   20


<210>  36282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36282
uucugcacua aauuuuccua                                                   20


<210>  36283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36283
cagauucccu ggggucugga                                                   20


<210>  36284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36284
cuggggucug gaaacauagu                                                   20


<210>  36285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36285
agaccccagg gaaucuggga                                                   20


<210>  36286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36286
aauuacauga caccuccacu                                                   20


<210>  36287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36287
cuuuugaguu ucaauuucuu                                                   20


<210>  36288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36288
auuucuucaa gagcaaagag                                                   20


<210>  36289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36289
ucaagagcaa agaggcagag                                                   20


<210>  36290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36290
agagcaaaga ggcagaggag                                                   20


<210>  36291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36291
uagcucuccu cugccucuuu                                                   20


<210>  36292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36292
accugcugcc uccgaaccuu                                                   20


<210>  36293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36293
gaggcagcag guagaaggca                                                   20


<210>  36294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36294
accuugacag caagcacaca                                                   20


<210>  36295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36295
ugauucaacc uugacagcaa                                                   20


<210>  36296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36296
uuuaaaauua agauacauau                                                   20


<210>  36297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36297
cuaaaaacaa aaacauccau                                                   20


<210>  36298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36298
aaacaucuuu uucuucuugg                                                   20


<210>  36299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36299
ucuugguauu acuaucuuau                                                   20


<210>  36300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36300
ugguauuacu aucuuaugaa                                                   20


<210>  36301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36301
uaagauagua auaccaagaa                                                   20


<210>  36302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36302
aaacagauca uuggaauucc                                                   20


<210>  36303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36303
aaugaucugu uuugaaugau                                                   20


<210>  36304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36304
uaaaaucauu cagcucugug                                                   20


<210>  36305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36305
gcucugugau ggcaucaugg                                                   20


<210>  36306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36306
acuggccaug augccaucac                                                   20


<210>  36307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36307
uuccacuggc caugaugcca                                                   20


<210>  36308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36308
cugucgucuu cggugucgug                                                   20


<210>  36309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36309
gugucgugau gugcuuggca                                                   20


<210>  36310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36310
uuuucauaua cccacuuuga                                                   20


<210>  36311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36311
uauacccacu uugaacguug                                                   20


<210>  36312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36312
aaguggguau augaaaacga                                                   20


<210>  36313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36313
caggcucugc augugugucu                                                   20


<210>  36314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36314
cauacacaga cacacaugca                                                   20


<210>  36315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36315
aaagagaaga gagcauauuc                                                   20


<210>  36316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36316
cuuuugaaac gucucuaacc                                                   20


<210>  36317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36317
uuacucucag caauuuguaa                                                   20


<210>  36318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36318
cagggaaaaa aauucaagaa                                                   20


<210>  36319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36319
cugagaagau uacaaauugc                                                   20


<210>  36320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36320
agaaacagua agauaaccua                                                   20


<210>  36321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36321
ugaauuuuuu ucccugagaa                                                   20


<210>  36322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36322
gaauauaaag uuccuguuca                                                   20


<210>  36323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36323
gaaucuaucu guaccuuagg                                                   20


<210>  36324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36324
uguucauuca caugaaacgc                                                   20


<210>  36325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36325
uucacaugaa acgcuaaaag                                                   20


<210>  36326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36326
caugaaacgc uaaaaguucu                                                   20


<210>  36327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36327
ugugaaugaa caggaacuuu                                                   20


<210>  36328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36328
ucacuugauc uuagccaaaa                                                   20


<210>  36329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36329
cuugaucuua gccaaaaggc                                                   20


<210>  36330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36330
uggccuuuug gcuaagauca                                                   20


<210>  36331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36331
uaaaucgaac uugccgugaa                                                   20


<210>  36332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36332
auuuaagaau uuuuaguguu                                                   20


<210>  36333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36333
cggcaaguuc gauuuaagaa                                                   20


<210>  36334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36334
gggcuuucug uuuugccuga                                                   20


<210>  36335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36335
guuuugccug augauuuugc                                                   20


<210>  36336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36336
uuauuuaagc uccagcaaaa                                                   20


<210>  36337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36337
acaggcuggg ggcuugcaca                                                   20


<210>  36338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36338
uaaaaccaca cuagcuccuu                                                   20


<210>  36339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36339
uugagcuuuu ugaacugauc                                                   20


<210>  36340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36340
aaaagcucaa agaaagauuu                                                   20


<210>  36341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36341
agcauugccc uauugacccc                                                   20


<210>  36342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36342
agcaaaggag ucagggaggg                                                   20


<210>  36343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36343
aaagccuaca gauuccagca                                                   20


<210>  36344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36344
cacaucuggg aguuugcaag                                                   20


<210>  36345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36345
acucagcgug ugugcagaag                                                   20


<210>  36346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36346
gcacacacgc ugagucgaaa                                                   20


<210>  36347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36347
gauucacaca gccaaaguau                                                   20


<210>  36348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36348
cacagccaaa guauagauua                                                   20


<210>  36349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36349
uggacuugga gggucuuugg                                                   20


<210>  36350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36350
guccaaagac ccuccaaguc                                                   20


<210>  36351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36351
cagcacaaag uacugggugu                                                   20


<210>  36352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36352
guggcaugca cgcaugggua                                                   20


<210>  36353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36353
ugugugugca ugucucaggg                                                   20


<210>  36354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36354
cugagggguc agagggugcc                                                   20


<210>  36355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36355
uaugugcuca ugacauugag                                                   20


<210>  36356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36356
uuggcacaca ggcacacucu                                                   20


<210>  36357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36357
uauauuuuuu uauauguggu                                                   20


<210>  36358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36358
cccaagucuu auuuuggucu                                                   20


<210>  36359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36359
acauaauaca uuuagucaaa                                                   20


<210>  36360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36360
gaugaaucaa guagauuauu                                                   20


<210>  36361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36361
ucugaaaaga caauaaagac                                                   20


<210>  36362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36362
ugagaccagg aauguugcug                                                   20


<210>  36363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36363
uggucucaag aauaaucuac                                                   20


<210>  36364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36364
aaauaaccaa aacagcaaca                                                   20


<210>  36365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36365
aauugacuuu ugaauuugag                                                   20


<210>  36366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36366
aaagucaauu ugaaaaugau                                                   20


<210>  36367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36367
gaaguggugu uaaauuauag                                                   20


<210>  36368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36368
gaaaaaaggu gacucaaauu                                                   20


<210>  36369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36369
uuuuuuagaa gucaucacaa                                                   20


<210>  36370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36370
aaaaaaagaa aaaaaaccua                                                   20


<210>  36371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36371
gaggaagagc uuugaccuuc                                                   20


<210>  36372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36372
ucugaacacu gaucauuuug                                                   20


<210>  36373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36373
acaugguaua augauugaua                                                   20


<210>  36374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36374
ucucuuacca uaaaccaagu                                                   20


<210>  36375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36375
uuauuucuug aaagcauuuu                                                   20


<210>  36376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36376
ugaaagcauu uuguagaugu                                                   20


<210>  36377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36377
agaaauaaag aaaacccuua                                                   20


<210>  36378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36378
aaauguaauu uccaugaaau                                                   20


<210>  36379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36379
augaaaugcc ugauaagggu                                                   20


<210>  36380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36380
uggaaauuac auuuggaaaa                                                   20


<210>  36381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36381
ucuuaauaca aagaggucgu                                                   20


<210>  36382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36382
ugcaucagcu uuauuuguuc                                                   20


<210>  36383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36383
agcucuuuuc cugcaucagc                                                   20


<210>  36384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36384
ucuuaccuga ugguacugga                                                   20


<210>  36385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36385
aacauacauu ccucuuaccu                                                   20


<210>  36386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36386
aucugcacgg gucaauaaag                                                   20


<210>  36387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36387
uuccaucugc acgggucaau                                                   20


<210>  36388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36388
aaguaacaca guuaacagug                                                   20


<210>  36389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36389
ggggccuggg uagaugccgg                                                   20


<210>  36390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36390
ccugccucca ccucccgagu                                                   20


<210>  36391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36391
ccaugauggc caagcuguuu                                                   20


<210>  36392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36392
aacuccugac cucaagugau                                                   20


<210>  36393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36393
aaacagcuug gccaucaugg                                                   20


<210>  36394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36394
ccugacuccu ggucugagag                                                   20


<210>  36395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36395
agauagugag gcccucuuuu                                                   20


<210>  36396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36396
aaaacgagga ccaaaaauca                                                   20


<210>  36397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36397
accaucuuga ccaacacugu                                                   20


<210>  36398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36398
aucauuuuaa gguuucuacc                                                   20


<210>  36399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36399
gaguugagau uucuaucauu                                                   20


<210>  36400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36400
uugagcugau uucugguuuu                                                   20


<210>  36401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36401
gguuuuguuu ucuuaaagug                                                   20


<210>  36402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36402
uaaaguggca uaagaauuca                                                   20


<210>  36403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36403
uaugccacuu uaagaaaaca                                                   20


<210>  36404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36404
aagacauuuu gaggaaggcu                                                   20


<210>  36405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36405
ucaaaauguc uuugaauucu                                                   20


<210>  36406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36406
gcacucagcc uuccucaaaa                                                   20


<210>  36407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36407
ccuuucuuuu aacuugcacu                                                   20


<210>  36408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36408
uuuaacuugc acuguugucu                                                   20


<210>  36409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36409
uuuuagcugu uugucuuuga                                                   20


<210>  36410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36410
aagacaaaca gcuaaaaaga                                                   20


<210>  36411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36411
uaaagccaua gcuuuucuca                                                   20


<210>  36412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36412
cauaagaagc agcacuuucu                                                   20


<210>  36413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36413
uaugagaaaa gcuauggcuu                                                   20


<210>  36414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36414
uuguucauuc auauuuuaau                                                   20


<210>  36415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36415
uucauauuuu aaugaacccc                                                   20


<210>  36416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36416
uauuuuaaug aaccccugua                                                   20


<210>  36417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36417
uuaaaauaug aaugaacaaa                                                   20


<210>  36418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36418
gaccucuuua ugauacaugu                                                   20


<210>  36419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36419
ucagccacau guucagugag                                                   20


<210>  36420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36420
gugagcucug gauaugucug                                                   20


<210>  36421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36421
aaacagacau auccagagcu                                                   20


<210>  36422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36422
cagagguaua caugguugag                                                   20


<210>  36423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36423
guagauugcc ucugcagaga                                                   20


<210>  36424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36424
cugcagaggc aaucuacuga                                                   20


<210>  36425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36425
guguucucug cagaggcaau                                                   20


<210>  36426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36426
auucuguguu cucugcagag                                                   20


<210>  36427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36427
cuucaauucu guguucucug                                                   20


<210>  36428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36428
gcagguggcu cauugccuuu                                                   20


<210>  36429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36429
aacacagccu ugacuaaacu                                                   20


<210>  36430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36430
uguugugccu uuucucugau                                                   20


<210>  36431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36431
cugauuguga aauauuacaa                                                   20


<210>  36432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36432
caaucagaga aaaggcacaa                                                   20


<210>  36433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36433
auacaaauaa caaugauggc                                                   20


<210>  36434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36434
ucuagggcac auacaaggug                                                   20


<210>  36435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36435
uucugauucc ccuacauuuc                                                   20


<210>  36436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36436
gauuccccua cauuucucau                                                   20


<210>  36437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36437
ccuacauuuc ucaugucaua                                                   20


<210>  36438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36438
caugucauag aguggggguu                                                   20


<210>  36439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36439
agcugaacug ggacaaguau                                                   20


<210>  36440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36440
gcuggaagac ucuaggaucc                                                   20


<210>  36441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36441
accccuacgu guccgucugu                                                   20


<210>  36442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36442
aauugugcac gcucuuauag                                                   20


<210>  36443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36443
uucuuguccu gcagcagugc                                                   20


<210>  36444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36444
uguccugcag cagugccaca                                                   20


<210>  36445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36445
ccuuguggca cugcugcagg                                                   20


<210>  36446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36446
uucuccuugu ggcacugcug                                                   20


<210>  36447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36447
acuugucuuc auucuccuug                                                   20


<210>  36448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36448
caaggaccuu aagcuaccau                                                   20


<210>  36449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36449
agccacccac cuuucacaag                                                   20


<210>  36450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36450
uucaguccua aucugugccu                                                   20


<210>  36451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36451
guccuaaucu gugccuugau                                                   20


<210>  36452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36452
ccgugcuagu caugggacag                                                   20


<210>  36453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36453
uuucuucuca caaugccauc                                                   20


<210>  36454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36454
ucucacaaug ccaucucagg                                                   20


<210>  36455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36455
cacaaugcca ucucagguug                                                   20


<210>  36456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36456
ggcuuuagag uuagccuugg                                                   20


<210>  36457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36457
ggucaaccca guguuuuauu                                                   20


<210>  36458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36458
uuuccuuucc cuuccuuucc                                                   20


<210>  36459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36459
uuucccuucc uuuccuuucc                                                   20


<210>  36460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36460
cuuccuuucc uuuccgacag                                                   20


<210>  36461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36461
uuuccuuucc gacagggucu                                                   20


<210>  36462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36462
uuuccgacag ggucucacuc                                                   20


<210>  36463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36463
gacagggucu cacucuguca                                                   20


<210>  36464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36464
accaauucuc ccaccucagc                                                   20


<210>  36465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36465
cccaccucag ccuccugagu                                                   20


<210>  36466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36466
ucacuaauca gaauuucuau                                                   20


<210>  36467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36467
gauuagugau gaauaggcca                                                   20


<210>  36468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36468
augaucaaau gacaugaauc                                                   20


<210>  36469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36469
ugucauuuga ucauagaaau                                                   20


<210>  36470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36470
acaacugcag uggaaggaaa                                                   20


<210>  36471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36471
acugcaguug uggaaacaau                                                   20


<210>  36472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36472
uuccacugca guuguggaaa                                                   20


<210>  36473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36473
gaagcagccu gcccccaguc                                                   20


<210>  36474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36474
gaaacuggca cugccaggcc                                                   20


<210>  36475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36475
cugugagcua cagaggugcu                                                   20


<210>  36476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36476
ggcagagcug ccucaaggag                                                   20


<210>  36477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36477
ucuugauuau acacaauaaa                                                   20


<210>  36478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36478
ugacugcacc cccauucuga                                                   20


<210>  36479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36479
gauuucauaa uggaauguua                                                   20


<210>  36480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36480
uaauggaaug uuaucuugag                                                   20


<210>  36481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36481
auuaugaaau cagaaugggg                                                   20


<210>  36482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36482
ggugagauug acagcaguuu                                                   20


<210>  36483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36483
aaaaccaucu guaggcaggg                                                   20


<210>  36484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36484
agggcaccau ucuaaaacca                                                   20


<210>  36485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36485
uuucugugcg uaaucugagu                                                   20


<210>  36486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36486
gugcguaauc ugaguagagu                                                   20


<210>  36487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36487
aucuccacuc uacucagauu                                                   20


<210>  36488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36488
ggccuucgau cuccacucua                                                   20


<210>  36489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36489
auugcggcag auauuaaguc                                                   20


<210>  36490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36490
uaaauguugu aucacacaau                                                   20


<210>  36491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36491
gaaguagugc uagauacuau                                                   20


<210>  36492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36492
gaaugcaaca ugcaccugug                                                   20


<210>  36493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36493
uuaaucugcu uugaucacug                                                   20


<210>  36494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36494
uggagugaag auuuuguugg                                                   20


<210>  36495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36495
cuccaagaag gcaggggguc                                                   20


<210>  36496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36496
auugucuguc cccuuacccg                                                   20


<210>  36497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36497
cucacuugcu uuucuauugu                                                   20


<210>  36498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36498
ugaucagccg ccaugguaua                                                   20


<210>  36499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36499
guacgguguu ccugaucagc                                                   20


<210>  36500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36500
ucuguacggu guuccugauc                                                   20


<210>  36501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36501
cuccuggauu cuucuguacg                                                   20


<210>  36502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36502
gcuggugaug agaagaagcu                                                   20


<210>  36503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36503
caucaccagc ugaacaaugc                                                   20


<210>  36504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36504
ucucaucacc agcugaacaa                                                   20


<210>  36505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36505
cucaaauguc accagaucac                                                   20


<210>  36506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36506
gcaaauucac ucaaauguca                                                   20


<210>  36507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36507
uuucugcaaa uucacucaaa                                                   20


<210>  36508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36508
ccagguaucu ccuaggcuug                                                   20


<210>  36509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36509
uuccccaggu aucuccuagg                                                   20


<210>  36510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36510
aggcagagca aauagcagug                                                   20


<210>  36511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36511
cuccccaugg cugccccacu                                                   20


<210>  36512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36512
uauuccugag uugagaauag                                                   20


<210>  36513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36513
ugaguugaga auagccuuga                                                   20


<210>  36514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36514
caacucagga auaagaauga                                                   20


<210>  36515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36515
acuccagugc cgggucucac                                                   20


<210>  36516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36516
ugcugccaag ggaugcugac                                                   20


<210>  36517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36517
gggugaggac aggguggcug                                                   20


<210>  36518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36518
agcuccuccu ccucuccagc                                                   20


<210>  36519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36519
uaaagccaag auuuuuuuua                                                   20


<210>  36520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36520
caaggugcug acagcagaug                                                   20


<210>  36521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36521
cauuaggguu uggcucccuu                                                   20


<210>  36522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36522
ugaaaggaca ggagagagac                                                   20


<210>  36523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36523
ggaacacauu cccauuaggg                                                   20


<210>  36524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36524
caagucucuc uccuguccuu                                                   20


<210>  36525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36525
aguaaaaccu uuucccaagu                                                   20


<210>  36526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36526
cucuucaagu aaaaccuuuu                                                   20


<210>  36527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36527
ccguucccuc uucaaguaaa                                                   20


<210>  36528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36528
gccaacuuaa cccauugccg                                                   20


<210>  36529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36529
uuucugccaa cuuaacccau                                                   20


<210>  36530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36530
gcccucagug cguaaacagg                                                   20


<210>  36531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36531
ugacacagga gacacaaauc                                                   20


<210>  36532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36532
cagacauggg uuaggauugg                                                   20


<210>  36533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36533
cccagaguug cuggggagga                                                   20


<210>  36534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36534
ugcauccugg acccucgccu                                                   20


<210>  36535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36535
cuuguuguaa gauguggcca                                                   20


<210>  36536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36536
caucugugcc uugaaaaaca                                                   20


<210>  36537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36537
aggcacagau gugaagcuca                                                   20


<210>  36538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36538
acugagugug uauacauagu                                                   20


<210>  36539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36539
aauuuuuguu ucuacugagu                                                   20


<210>  36540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36540
accauuacuu auugauggug                                                   20


<210>  36541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36541
ggccaggugu gguggcucau                                                   20


<210>  36542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36542
ccauguugcc caggcugguc                                                   20


<210>  36543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36543
aguagagaca ggguuucacc                                                   20


<210>  36544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36544
ugcgccacug cacuccuggg                                                   20


<210>  36545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36545
aacagagucu cacucugugc                                                   20


<210>  36546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36546
cucucucucu uucuaacaga                                                   20


<210>  36547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36547
uucucucucu cucuuucuaa                                                   20


<210>  36548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36548
ucccucccuc ucucuucuuu                                                   20


<210>  36549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36549
uuccucccuc ccucucucuu                                                   20


<210>  36550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36550
uuccuuccuc ccucccucuc                                                   20


<210>  36551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36551
uuccuuccuu ccucccuccc                                                   20


<210>  36552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36552
auuuauuucc uuccuuccuu                                                   20


<210>  36553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36553
uccauuuauu uccuuccuuc                                                   20


<210>  36554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36554
auuucuucca uuuauuuccu                                                   20


<210>  36555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36555
ucccuuccau uucuuccauu                                                   20


<210>  36556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36556
ucccuccccu uccucccuuc                                                   20


<210>  36557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36557
uuccucccuc cccuuccucc                                                   20


<210>  36558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36558
uccuuccucc cuccccuucc                                                   20


<210>  36559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36559
uuucuuccuu ccucccuccc                                                   20


<210>  36560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36560
gccaguugcc uugggaguuc                                                   20


<210>  36561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36561
ccauugcacu ggguuaagug                                                   20


<210>  36562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36562
cacuuaaccc agugcaaugg                                                   20


<210>  36563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36563
aaacaacuaa aacaaaaccu                                                   20


<210>  36564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36564
uauagccaua uccuugcccc                                                   20


<210>  36565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36565
uaaucugccc cauguuccua                                                   20


<210>  36566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36566
gcacuccauc ccucccacaa                                                   20


<210>  36567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36567
uuuucugcac uccaucccuc                                                   20


<210>  36568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36568
aagcgucccu uuguauacac                                                   20


<210>  36569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36569
cacuuuugua uauuugaguc                                                   20


<210>  36570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36570
guaaaagacu caaauauaca                                                   20


<210>  36571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36571
guuaugggaa aaauguagcu                                                   20


<210>  36572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36572
cauaacagaa aucuugucau                                                   20


<210>  36573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36573
ccacugaacu uaaaaugcuu                                                   20


<210>  36574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36574
guggugaacc aagcaaacau                                                   20


<210>  36575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36575
cucauuuaaa agcauuuuaa                                                   20


<210>  36576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36576
uguacaccag cuauguaacu                                                   20


<210>  36577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36577
uuuggcuuac guagaaaugu                                                   20


<210>  36578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36578
acguaagcca aaagaaacga                                                   20


<210>  36579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36579
acagaugcac auugacucuc                                                   20


<210>  36580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36580
ugagagucaa ugugcaucug                                                   20


<210>  36581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36581
ucccuccguc cgguagacau                                                   20


<210>  36582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36582
ucacuccaaa cacaauggug                                                   20


<210>  36583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36583
ucugcugagc caggcgagag                                                   20


<210>  36584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36584
ggcucugauu acugggacca                                                   20


<210>  36585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36585
gggggugguc ccaguaauca                                                   20


<210>  36586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36586
ugagaguuug cuuuuuuuuu                                                   20


<210>  36587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36587
gcaccacccc cacaccaaaa                                                   20


<210>  36588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36588
agcuucacac cauucuccug                                                   20


<210>  36589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36589
caccauucuc cugccucagc                                                   20


<210>  36590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36590
ccugccucag ccucccgagu                                                   20


<210>  36591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36591
ccguguuagc caggaugguc                                                   20


<210>  36592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36592
agcaauuuuc cugccucagc                                                   20


<210>  36593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36593
ugccucagcc ucccgaguag                                                   20


<210>  36594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36594
cuguguuagc caggaugguc                                                   20


<210>  36595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36595
caggugaaac uaaugccugc                                                   20


<210>  36596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36596
ccugggaauu ugcuaaaaau                                                   20


<210>  36597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36597
gggagcacac uuugggacuc                                                   20


<210>  36598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36598
uucacaaaau uggcaauugg                                                   20


<210>  36599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36599
caaaauuggc aauuggggga                                                   20


<210>  36600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36600
cccaauugcc aauuuuguga                                                   20


<210>  36601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36601
uuuuuucuuc agcugugacu                                                   20


<210>  36602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36602
ucagcuguga cuuauguauu                                                   20


<210>  36603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36603
gcugugacuu auguauuaug                                                   20


<210>  36604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36604
acuguggaua ucgggaauuc                                                   20


<210>  36605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36605
cgauauccac aguugaacag                                                   20


<210>  36606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36606
ggccauuuug aggguucuga                                                   20


<210>  36607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36607
gauuucccag ucaacugaag                                                   20


<210>  36608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36608
cagucaacug aagauauugu                                                   20


<210>  36609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36609
guugacuggg aaaucagaac                                                   20


<210>  36610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36610
uucucguauu caggagcucu                                                   20


<210>  36611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36611
cguauucagg agcucuccuu                                                   20


<210>  36612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36612
ggagcucucc uucucuccgu                                                   20


<210>  36613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36613
cuccguauuu aaucuccugu                                                   20


<210>  36614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36614
acgcuagaag aacacaguga                                                   20


<210>  36615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36615
agcguugaag uacugucccc                                                   20


<210>  36616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36616
ucuagcguug aaguacuguc                                                   20


<210>  36617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36617
cuguguucuu cuagcguuga                                                   20


<210>  36618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36618
cuucacugug uucuucuagc                                                   20


<210>  36619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36619
uuauuuguuu cccuucacug                                                   20


<210>  36620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36620
ggcaaauucu uuauuuguuu                                                   20


<210>  36621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36621
ucuggcaaau ucuuuauuug                                                   20


<210>  36622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36622
agguaugcuu ucuaucugag                                                   20


<210>  36623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36623
aucugagccu auaacuaacc                                                   20


<210>  36624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36624
caaaaggcau ggguuaguua                                                   20


<210>  36625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36625
cagucaguaa gucuggaaua                                                   20


<210>  36626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36626
agacuuacug acugugaaac                                                   20


<210>  36627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36627
cuucugaguu ggguaaagaa                                                   20


<210>  36628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36628
gaguugggua aagaagucug                                                   20


<210>  36629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36629
uuacccaacu cagaagugaa                                                   20


<210>  36630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36630
aauccguccu gcauuaucua                                                   20


<210>  36631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36631
uaccugucuu gaaguucugu                                                   20


<210>  36632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36632
agacagguau gaaccaagag                                                   20


<210>  36633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36633
gucauguucu gucucuuguc                                                   20


<210>  36634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36634
gucucuuguc cucaguagag                                                   20


<210>  36635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36635
cugacgucag cgugccccua                                                   20


<210>  36636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36636
acuucccuga cgucagcgug                                                   20


<210>  36637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36637
cuuggguuuc aacuucccug                                                   20


<210>  36638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36638
cccugcaggg cagccugccu                                                   20


<210>  36639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36639
cucauaaauu guuuggaagc                                                   20


<210>  36640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36640
aaacaauuua ugagggaaga                                                   20


<210>  36641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36641
gagcauucac ugaguuagag                                                   20


<210>  36642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36642
cugaguuaga gcugcuucug                                                   20


<210>  36643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36643
gcaaaugugc ugcuucugcu                                                   20


<210>  36644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36644
gcuaaguggc ugugacuuca                                                   20


<210>  36645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36645
ugcagccuuc acuugguuug                                                   20


<210>  36646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36646
cuugguuugu caucagugga                                                   20


<210>  36647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36647
acaacacagg gcaucuccac                                                   20


<210>  36648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36648
gcaggcagcc cauggcuuuc                                                   20


<210>  36649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36649
cugugucgca uugaagcagc                                                   20


<210>  36650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36650
augcgacaca gggaaagcca                                                   20


<210>  36651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36651
ugugacagau gaucagcuug                                                   20


<210>  36652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36652
caaagcuuaa aaaaaugcua                                                   20


<210>  36653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36653
uccucaguga ggaaggugau                                                   20


<210>  36654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36654
ucacugagga ugaaauggca                                                   20


<210>  36655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36655
cuuuagcggu uaauguacuc                                                   20


<210>  36656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36656
uguauacuug gcguaagugc                                                   20


<210>  36657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36657
cugucaucuu uuuuguuucu                                                   20


<210>  36658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36658
uggaagguuu cuauuacaac                                                   20


<210>  36659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36659
aagaaacaaa aaagaugaca                                                   20


<210>  36660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36660
auuacaacug guugguauuc                                                   20


<210>  36661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36661
uuuagaagac auuguuacaa                                                   20


<210>  36662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36662
aaaagaauac caaccaguug                                                   20


<210>  36663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36663
gcuguuuugu aacaaugucu                                                   20


<210>  36664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36664
accuucagcu guuuuguaac                                                   20


<210>  36665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36665
auugccagga acuaggcaca                                                   20


<210>  36666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36666
uggcaauaga aaguauguug                                                   20


<210>  36667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36667
agucugguag gugaaucaca                                                   20


<210>  36668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36668
ccuaccagac uugaagaugu                                                   20


<210>  36669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36669
uggagugucu cguuccccau                                                   20


<210>  36670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36670
ccauucugca cuauacacuc                                                   20


<210>  36671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36671
gcacuauaca cucucagagu                                                   20


<210>  36672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36672
accgggcagc acagcuccua                                                   20


<210>  36673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36673
acuggcacac ugggcaaggc                                                   20


<210>  36674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36674
acucuugggu auauacccaa                                                   20


<210>  36675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36675
uuuggguaua uacccaagag                                                   20


<210>  36676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36676
auucuuuugg guauauaccc                                                   20


<210>  36677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36677
ccacccugcu uuccauucuu                                                   20


<210>  36678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36678
uagcagcauu auucacgaua                                                   20


<210>  36679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36679
cgauagcuaa aauguggaac                                                   20


<210>  36680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36680
acauuuuagc uaucgugaau                                                   20


<210>  36681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36681
guugguucca cauuuuagcu                                                   20


<210>  36682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36682
uccaucgagg gacacuucag                                                   20


<210>  36683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36683
acuguaaaua uacaccagau                                                   20


<210>  36684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36684
gccuuaaaaa aaggacauuc                                                   20


<210>  36685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36685
gacacaugcu acaacauggg                                                   20


<210>  36686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36686
uuuagcauaa uguccuuaag                                                   20


<210>  36687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36687
acuuacauga gggaccugga                                                   20


<210>  36688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36688
uagauauaga aaguagaaug                                                   20


<210>  36689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36689
auaucuauga auuaacuacu                                                   20


<210>  36690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36690
acuuucuaua ucuaugaauu                                                   20


<210>  36691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36691
ucuuguaaaa auaacucccc                                                   20


<210>  36692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36692
agaaaugaau gguggugaug                                                   20


<210>  36693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36693
agaauaacuc ucuucaucuu                                                   20


<210>  36694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36694
uuucuagaau aacucucuuc                                                   20


<210>  36695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36695
uaauguuaua caaccaucac                                                   20


<210>  36696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36696
guagcauuaa guacauucau                                                   20


<210>  36697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36697
ggcaugagcc augacaccug                                                   20


<210>  36698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36698
ugccacugca cuccagccuc                                                   20


<210>  36699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36699
agugauccuu uuaccuugac                                                   20


<210>  36700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36700
uuguagagau aggggucucg                                                   20


<210>  36701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36701
aggcugcagg gagcuauuau                                                   20


<210>  36702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36702
guagcccagg cuggagugca                                                   20


<210>  36703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36703
uccuccugug uuaaauuugg                                                   20


<210>  36704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36704
ccguccuuga ucauuuguaa                                                   20


<210>  36705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36705
ggugugagcu accaugccca                                                   20


<210>  36706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36706
cuagagacau ggucucgauc                                                   20


<210>  36707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36707
uucucuagag acauggucuc                                                   20


<210>  36708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36708
cuguccuugu cauuuucuuu                                                   20


<210>  36709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36709
uggguucacu guccuuguca                                                   20


<210>  36710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36710
augcuugcug cacagcuggc                                                   20


<210>  36711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36711
aagaagaacg aucguuugua                                                   20


<210>  36712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36712
uggaaaacac acuguccuaa                                                   20


<210>  36713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36713
ucuuggaaaa cacacugucc                                                   20


<210>  36714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36714
cauuacaaac gaucguucuu                                                   20


<210>  36715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36715
agcuauuuag ucauuuauuu                                                   20


<210>  36716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36716
aggggauagg cacgucuuuc                                                   20


<210>  36717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36717
ucucucaaga aaauagaaag                                                   20


<210>  36718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36718
cucaagaaaa uagaaaggca                                                   20


<210>  36719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36719
ugagagaaga aagacgugcc                                                   20


<210>  36720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36720
auuuucuuga gagaagaaag                                                   20


<210>  36721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36721
aauuucuagu aacagcaaac                                                   20


<210>  36722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36722
aguaacagca aacagcauua                                                   20


<210>  36723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36723
gcaguugauc uguuggaagc                                                   20


<210>  36724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36724
aacagaucaa cugcugaaca                                                   20


<210>  36725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36725
ccuuuaagcg gcuuaggagu                                                   20


<210>  36726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36726
auaggucuuu gaucgugacu                                                   20


<210>  36727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36727
aggauccuug gcucucuugg                                                   20


<210>  36728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36728
caagagagcc aaggauccua                                                   20


<210>  36729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36729
gauagucaua auguaaauac                                                   20


<210>  36730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36730
uucuuucuuu cuuucuuucu                                                   20


<210>  36731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36731
uucuuucuuu cuuucuuuuu                                                   20


<210>  36732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36732
uucuuucuuu cuuuuuuuuu                                                   20


<210>  36733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36733
uucuuucuuu uuuuuuuuga                                                   20


<210>  36734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36734
uucuuuuuuu uuuugagaca                                                   20


<210>  36735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36735
uuuuuuuuuu gagacagagu                                                   20


<210>  36736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36736
cucuuguugc ccauccugga                                                   20


<210>  36737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36737
agcaauucuc cugccucagc                                                   20


<210>  36738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36738
ccugccucag ccucccgagu                                                   20


<210>  36739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36739
ccauguugag gcuggucucg                                                   20


<210>  36740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36740
agaccagccu caacauggag                                                   20


<210>  36741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36741
uuuuugaaau caauguauga                                                   20


<210>  36742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36742
aaaaugaaag cucgggccgg                                                   20


<210>  36743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36743
gucauacauu gauuucaaaa                                                   20


<210>  36744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36744
guguuucagu cauacauuga                                                   20


<210>  36745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36745
gaacagaaug aaaaugucuu                                                   20


<210>  36746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36746
gaaaccauaa uuaagucagu                                                   20


<210>  36747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36747
guucugaaac cauaauuaag                                                   20


<210>  36748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36748
uucuguucug aaaccauaau                                                   20


<210>  36749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36749
guucugauga auauaaaagg                                                   20


<210>  36750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36750
gaugaauaua aaaggaaaac                                                   20


<210>  36751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36751
ucagaaccga agacauuuuc                                                   20


<210>  36752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36752
uuuuauauuc aucagaaccg                                                   20


<210>  36753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36753
acuccccacc ucuaucucua                                                   20


<210>  36754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36754
ccuuccacuc cccaccucua                                                   20


<210>  36755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36755
ccuagcauug uugggauuau                                                   20


<210>  36756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36756
gaugauguaa ccauauaauc                                                   20


<210>  36757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36757
gaggucucca aauagaacua                                                   20


<210>  36758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36758
auuuggagac cucugaagcc                                                   20


<210>  36759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36759
gauuguuagg agguaguaua                                                   20


<210>  36760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36760
gacaacuuua gacaucaccc                                                   20


<210>  36761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36761
acagucuuuc aguugcaggg                                                   20


<210>  36762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36762
guugcaggga uaaaacccca                                                   20


<210>  36763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36763
cuuacucuag uuuaaacugg                                                   20


<210>  36764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36764
uucucuuacu cuaguuuaaa                                                   20


<210>  36765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36765
aggagcuuaa accaacacau                                                   20


<210>  36766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36766
guggucugca uuguauauuu                                                   20


<210>  36767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36767
ucuuuucauu uauauaauuu                                                   20


<210>  36768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36768
uuucauuuau auaauuuuua                                                   20


<210>  36769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36769
uuuauauaau uuuuaaauuu                                                   20


<210>  36770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36770
gccuaggcga caaagugaga                                                   20


<210>  36771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36771
ugccacugca cuucagccua                                                   20


<210>  36772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36772
aggcuagagu gagccucgca                                                   20


<210>  36773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36773
uccugccuca gccuucuaag                                                   20


<210>  36774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36774
ugccucagcc uucuaaguag                                                   20


<210>  36775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36775
aaguagcuga gacaauaggc                                                   20


<210>  36776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36776
acaaaaaaau uuuaaaaccu                                                   20


<210>  36777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36777
auuucuacaa aaaaauuuua                                                   20


<210>  36778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36778
ggcgauccuc cugccucugc                                                   20


<210>  36779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36779
uguguuaguu uuguucucug                                                   20


<210>  36780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36780
cuggugggcu guuuucacau                                                   20


<210>  36781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36781
caugaccgaa gaugaccucu                                                   20


<210>  36782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36782
gucaugugaa aacagcccac                                                   20


<210>  36783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36783
cagccccuca aguaggccua                                                   20


<210>  36784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36784
gggguuuaug gucacccaua                                                   20


<210>  36785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36785
auugaugagg agguggggcu                                                   20


<210>  36786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36786
aacugcugug cugcuauccc                                                   20


<210>  36787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36787
gguaguuacc uccaaaauuc                                                   20


<210>  36788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36788
guucugguag uuaccuccaa                                                   20


<210>  36789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36789
guuuucaguu cugguaguua                                                   20


<210>  36790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36790
cuuacuggau uuuuguacac                                                   20


<210>  36791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36791
gccuuggucc auuugaggau                                                   20


<210>  36792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36792
guugagcauc cuggcucuug                                                   20


<210>  36793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36793
gugcaggcaa gagccaggau                                                   20


<210>  36794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36794
agucagugcg ucaguaucac                                                   20


<210>  36795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36795
uaugaagaag aacaguagug                                                   20


<210>  36796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36796
uaggaaauau caagacuugu                                                   20


<210>  36797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36797
ucauaggaaa uaucaagacu                                                   20


<210>  36798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36798
ucuucauagg aaauaucaag                                                   20


<210>  36799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36799
ucugucacug cacuacuguu                                                   20


<210>  36800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36800
gagggagaga aguagcuagc                                                   20


<210>  36801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36801
cucccucaga aauccugccu                                                   20


<210>  36802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36802
cugcaaaaag cuagcuacuu                                                   20


<210>  36803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36803
ggcacccaag agagcagcug                                                   20


<210>  36804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36804
guggcgccgu gcggccgggc                                                   20


<210>  36805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36805
ccaggauucu guggcgccgu                                                   20


<210>  36806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36806
uggccucugc auucagcugc                                                   20


<210>  36807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36807
gcugcuguca cccuccgcac                                                   20


<210>  36808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36808
uaguggacuc uaguuuuuga                                                   20


<210>  36809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36809
auaauagcaa guaaggcuca                                                   20


<210>  36810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36810
uguuucuuuu uaaagaucuu                                                   20


<210>  36811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36811
uuuuaaagau cuucggauua                                                   20


<210>  36812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36812
gauuaugcuu cacugaccac                                                   20


<210>  36813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36813
cugaccacug uaauaaguuu                                                   20


<210>  36814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36814
caacuuuaaa cuuauuacag                                                   20


<210>  36815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36815
uuaacaagcc auauuuucuc                                                   20


<210>  36816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36816
aaggacuagu cuugccuuug                                                   20


<210>  36817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36817
guguccuucu acauguccga                                                   20


<210>  36818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36818
acauguccga gcgaucucug                                                   20


<210>  36819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36819
ucuccuucca ucucacaauu                                                   20


<210>  36820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36820
aucucacaau ugaggcaaaa                                                   20


<210>  36821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36821
acaguaacaa uauuuugccu                                                   20


<210>  36822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36822
agcagagaca ggaugucugc                                                   20


<210>  36823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36823
guaccugaaa uguggcuggu                                                   20


<210>  36824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36824
gguacagaac accacaugug                                                   20


<210>  36825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36825
caacagaccu gcacugucuc                                                   20


<210>  36826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36826
ugcugguauc uuuugaccuu                                                   20


<210>  36827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36827
gucuucuugu uuccuuugac                                                   20


<210>  36828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36828
uguuuccuuu gacugcauuu                                                   20


<210>  36829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36829
uuugacugca uuuauuugaa                                                   20


<210>  36830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36830
aauaaaugca gucaaaggaa                                                   20


<210>  36831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36831
gccaccuagu gucuuucaaa                                                   20


<210>  36832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36832
agauaagagu ugaaauaauu                                                   20


<210>  36833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36833
acucuuaucu ugaaaccaau                                                   20


<210>  36834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36834
ucucguguuu uuauauaagu                                                   20


<210>  36835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36835
cguacugcuu aaacaaaggc                                                   20


<210>  36836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36836
uagccuuugu uuaagcagua                                                   20


<210>  36837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36837
acccauaaac cgaaaaugaa                                                   20


<210>  36838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36838
guuuaugggu ggaauucaua                                                   20


<210>  36839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36839
uuuucgguuu auggguggaa                                                   20


<210>  36840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36840
ggcgugggua cuucuuaaau                                                   20


<210>  36841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36841
uaaauaauac cugguucagg                                                   20


<210>  36842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36842
ggaacuaguc agaauggcac                                                   20


<210>  36843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36843
ugaaccaggu auuauuuaag                                                   20


<210>  36844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36844
gacuaguucc ugaaccaggu                                                   20


<210>  36845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36845
ugcuuuuccu cuuguuggga                                                   20


<210>  36846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36846
ucuuguuggg agaggagggu                                                   20


<210>  36847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36847
ucccaaagug guuugccuau                                                   20


<210>  36848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36848
cauuccaucu aggauaagca                                                   20


<210>  36849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36849
aucuaggaua agcagaauag                                                   20


<210>  36850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36850
gcuuauccua gauggaaugu                                                   20


<210>  36851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36851
uggcuauucu gcuuauccua                                                   20


<210>  36852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36852
aaaccagucu aucuuggacc                                                   20


<210>  36853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36853
accuccuggg ccucuggugc                                                   20


<210>  36854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36854
gccacaugga caacaaacaa                                                   20


<210>  36855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36855
agcuuugcuc accgugauuu                                                   20


<210>  36856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36856
aggacacauc uugugcucuu                                                   20


<210>  36857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36857
cugccugcca uccagacuau                                                   20


<210>  36858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36858
ucccugaguc cuggucgugg                                                   20


<210>  36859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36859
ucuguggcag aggggauggc                                                   20


<210>  36860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36860
cuguccuuuc caaagcgucu                                                   20


<210>  36861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36861
aaagcgucug ugguuccacu                                                   20


<210>  36862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36862
acuuuuuggg gcaaagcagg                                                   20


<210>  36863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36863
ugcuuugccc caaaaagugg                                                   20


<210>  36864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36864
aguauuccug cuuugcccca                                                   20


<210>  36865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36865
cucucuucca guauuccugc                                                   20


<210>  36866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36866
auaguaauaa aguugacauu                                                   20


<210>  36867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36867
aguucaugcu uggggaaagg                                                   20


<210>  36868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36868
ugcuugggga aaggacaggg                                                   20


<210>  36869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36869
ccaagcauga acuugaauca                                                   20


<210>  36870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36870
auugcuccca gcauuauaau                                                   20


<210>  36871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36871
cauggguaug ugguagguuu                                                   20


<210>  36872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36872
uagaacugcu cugugaagua                                                   20


<210>  36873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36873
aagaauuaac ugggauaauu                                                   20


<210>  36874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36874
cagagcaguu cuaagaauua                                                   20


<210>  36875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36875
cgcuuugugc uuaaguucua                                                   20


<210>  36876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36876
aaaagauccu gugccaaaac                                                   20


<210>  36877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36877
ugguuuuggc acaggaucuu                                                   20


<210>  36878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36878
uucuugguuu uggcacagga                                                   20


<210>  36879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36879
uucuugccca ucgaucuuuc                                                   20


<210>  36880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36880
ugcccaucga ucuuucucuc                                                   20


<210>  36881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36881
cucaucaggc cacuucuugg                                                   20


<210>  36882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36882
uggguugaua guggugagug                                                   20


<210>  36883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36883
gaauacccac caugggcccc                                                   20


<210>  36884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36884
gaaaguggca gcggcuacac                                                   20


<210>  36885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36885
ccacgccaca cagugacugg                                                   20


<210>  36886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36886
cucuguguca uagcugaaca                                                   20


<210>  36887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36887
gcuaugacac agagagaacc                                                   20


<210>  36888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36888
gcccuaggag cucucgaugg                                                   20


<210>  36889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36889
accaucgaga gcuccuaggg                                                   20


<210>  36890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36890
aaacaggcag gaugugggau                                                   20


<210>  36891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36891
uuauuuccaa uuccugcuuc                                                   20


<210>  36892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36892
aauuccugcu uccauuguuc                                                   20


<210>  36893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36893
ugcuuccauu guuccuuuua                                                   20


<210>  36894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36894
auuguuccuu uuaauauuuc                                                   20


<210>  36895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36895
uuuuaauauu ucuuuguuua                                                   20


<210>  36896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36896
uuguuuagcu cacaaaaaca                                                   20


<210>  36897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36897
cugggugcag ccugcauccg                                                   20


<210>  36898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36898
ugcccgccuc cuuuccugca                                                   20


<210>  36899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36899
ugcacugcca ucguggucuc                                                   20


<210>  36900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36900
cuuccccuga gucccuuugg                                                   20


<210>  36901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36901
ccugaguccc uuuggcuccc                                                   20


<210>  36902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36902
uucugucuca gacugcugcu                                                   20


<210>  36903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36903
gucucagacu gcugcucauc                                                   20


<210>  36904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36904
uagggucccg aguagugaug                                                   20


<210>  36905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36905
accgagaagc aucuucucau                                                   20


<210>  36906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36906
cgguggaacc ucccuuccua                                                   20


<210>  36907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36907
caucucagcc acguucucag                                                   20


<210>  36908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36908
cagugccacu guugucuuug                                                   20


<210>  36909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36909
auggcuucac accagagaag                                                   20


<210>  36910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36910
caccagagaa gguuguuucu                                                   20


<210>  36911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36911
cuggugugaa gccauggaaa                                                   20


<210>  36912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36912
ugguuuuaug acaauguauu                                                   20


<210>  36913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36913
ugguucacgg augguuuucc                                                   20


<210>  36914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36914
cggaugguuu uccuccaugu                                                   20


<210>  36915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36915
uccauguggg aauucgggga                                                   20


<210>  36916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36916
cacauggagg aaaaccaucc                                                   20


<210>  36917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36917
gggacccagg cuccuuuccu                                                   20


<210>  36918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36918
uucuuuuggu ucuguucucc                                                   20


<210>  36919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36919
uuugguucug uucuccaggc                                                   20


<210>  36920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36920
guucuccagg ccuucacauc                                                   20


<210>  36921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36921
ccaggccuuc acauccucug                                                   20


<210>  36922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36922
cauccucugu gucugguugg                                                   20


<210>  36923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36923
cucuccuugu ccccaaccag                                                   20


<210>  36924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36924
uuaccuuccc ucuccuuguc                                                   20


<210>  36925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36925
cucgugguga caggucacag                                                   20


<210>  36926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36926
cagcagcagc acuguggucu                                                   20


<210>  36927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36927
gugaggauaa aaacagguga                                                   20


<210>  36928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36928
aggaugagga aagucaggga                                                   20


<210>  36929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36929
ucauccugga aucaccuguu                                                   20


<210>  36930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36930
cugacuuucc ucauccugga                                                   20


<210>  36931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36931
aaggguuucc cugacuuucc                                                   20


<210>  36932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36932
gaaugagcug cagcgagugc                                                   20


<210>  36933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36933
gaagccacca cuaaucccau                                                   20


<210>  36934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36934
aaagcuuuug cuauucugau                                                   20


<210>  36935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36935
gauaugccca caccaugccc                                                   20


<210>  36936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36936
ucacucucuc ugcggagagc                                                   20


<210>  36937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36937
caugagccuc uguccaguug                                                   20


<210>  36938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36938
ucccuccacc uggaagggac                                                   20


<210>  36939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36939
agguggaggg aggaacaacu                                                   20


<210>  36940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36940
ucauaacauc ccagcggaac                                                   20


<210>  36941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36941
gcugggaugu uaugaggaac                                                   20


<210>  36942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36942
auccuguccc caaguucauc                                                   20


<210>  36943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36943
uccucauccu ccugccggcu                                                   20


<210>  36944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36944
uggccccucu uaugucugcu                                                   20


<210>  36945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36945
ugacgccaca uccuucugga                                                   20


<210>  36946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36946
ggauucucug gaauugaauu                                                   20


<210>  36947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36947
cuggaauuga auuuugccuu                                                   20


<210>  36948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36948
agagaaucca gaaggaugug                                                   20


<210>  36949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36949
auuccagaga auccagaagg                                                   20


<210>  36950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36950
caaagugcac aggauuacag                                                   20


<210>  36951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36951
acauguugcu caggcuaauc                                                   20


<210>  36952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36952
auagaaaaua caaaaauuag                                                   20


<210>  36953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36953
auagaaacag gauuucaaca                                                   20


<210>  36954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36954
ugaguagcug ggaguauagg                                                   20


<210>  36955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36955
gacagggucu cacucuguuu                                                   20


<210>  36956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36956
ccguagcgaa acauguaugu                                                   20


<210>  36957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36957
cuacggugaa guaugcaaug                                                   20


<210>  36958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36958
uuuccugccu guagcugcuc                                                   20


<210>  36959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36959
ugccuguagc ugcucuuuua                                                   20


<210>  36960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36960
uuuaaggcug gcuuagugug                                                   20


<210>  36961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36961
ugugcccucc ugcuuccuuc                                                   20


<210>  36962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36962
uucaugaggg gucccucccu                                                   20


<210>  36963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36963
ugaggggucc cucccucugu                                                   20


<210>  36964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36964
cauugcccau ggugguuugu                                                   20


<210>  36965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36965
cucuuguuuc ucaagccaug                                                   20


<210>  36966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36966
caagccaugg cagccugccu                                                   20


<210>  36967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36967
uucuuucuag gucucucuca                                                   20


<210>  36968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36968
uucuaggucu cucucauccu                                                   20


<210>  36969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36969
aggucucucu cauccuaggc                                                   20


<210>  36970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36970
guggagcugc ccucuuguca                                                   20


<210>  36971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36971
cugucuagcc acuuaauuga                                                   20


<210>  36972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36972
ucgaguugcu guccaugguc                                                   20


<210>  36973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36973
cuguguuucu gccucucucc                                                   20


<210>  36974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36974
gccucucucc uuggccuugg                                                   20


<210>  36975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36975
cuugcugguc cuuguagucc                                                   20


<210>  36976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36976
cgacacggga cuuguccugc                                                   20


<210>  36977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36977
auuuuaagug caagucugag                                                   20


<210>  36978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36978
uguuaauuag aucauuaggg                                                   20


<210>  36979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36979
gaaucccagc aucauaguau                                                   20


<210>  36980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36980
gaacaucccu aaugaucuaa                                                   20


<210>  36981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36981
uccucccgcu accccaggaa                                                   20


<210>  36982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36982
ugggguagcg ggaggaggaa                                                   20


<210>  36983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36983
accugaacuu cccuaauagg                                                   20


<210>  36984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36984
gguggaagau gagacggacu                                                   20


<210>  36985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36985
cuaauaggcu ccagcagcug                                                   20


<210>  36986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36986
uccaugccuu gugcagugcu                                                   20


<210>  36987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36987
ccuguuugcu ccuuauuaca                                                   20


<210>  36988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36988
cagggcugua auaaggagca                                                   20


<210>  36989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36989
aucuuacacc uaaggaagcu                                                   20


<210>  36990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36990
uuagguguaa gauggaauua                                                   20


<210>  36991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36991
gaucguggcu cuacugucua                                                   20


<210>  36992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36992
gagccugugu ugacacucag                                                   20


<210>  36993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36993
agguggcuga gugucaacac                                                   20


<210>  36994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36994
auuaccuguu caaaaccccu                                                   20


<210>  36995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36995
aaaccccuac aucccggguc                                                   20


<210>  36996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36996
uugaaggcag ugcaugccuc                                                   20


<210>  36997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36997
aggaagaugc agccaggcca                                                   20


<210>  36998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36998
cucagggggc ccaugcagga                                                   20


<210>  36999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  36999
ugcaugggcc cccugaguga                                                   20


<210>  37000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37000
guggggcccu cuguuccugc                                                   20


<210>  37001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37001
gcacuggccu cauccuucug                                                   20


<210>  37002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37002
uggucagcau uguccccucc                                                   20


<210>  37003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37003
cuacacuugc uuccugguca                                                   20


<210>  37004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37004
ugggauuucu cuacacuugc                                                   20


<210>  37005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37005
aaugccuugu cucuggcucc                                                   20


<210>  37006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37006
cugagugugc ugcuucuguu                                                   20


<210>  37007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37007
guuagcucgc uuccuugguc                                                   20


<210>  37008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37008
uuggucucag guuauaguuu                                                   20


<210>  37009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37009
cuuuggggau guguugauuu                                                   20


<210>  37010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37010
agcaauucuu gugcucccgc                                                   20


<210>  37011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37011
ugugcucccg ccucccaaau                                                   20


<210>  37012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37012
agaccagccu gaccaacaug                                                   20


<210>  37013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37013
ggccgggugu gguggcucac                                                   20


<210>  37014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37014
gauuuaaauu ucaggccggg                                                   20


<210>  37015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37015
cuguuuccca agucuugcug                                                   20


<210>  37016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37016
caagucuugc ugccucuccc                                                   20


<210>  37017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37017
auccucuccu uuggauaaac                                                   20


<210>  37018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37018
uucuauccuc uccuuuggau                                                   20


<210>  37019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37019
uggagcccug agaaggaugc                                                   20


<210>  37020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37020
cagggcucca ggaaucauga                                                   20


<210>  37021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37021
ccacagcauc cuucucaggg                                                   20


<210>  37022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37022
accggcaaau uucuccacag                                                   20


<210>  37023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37023
caccuggccu ccuucagcau                                                   20


<210>  37024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37024
gcauuucugu cccucagucc                                                   20


<210>  37025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37025
gucccucagu ccuuagcaag                                                   20


<210>  37026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37026
ugccugugua gcuguggcuc                                                   20


<210>  37027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37027
aggcgcugag uguucccuga                                                   20


<210>  37028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37028
cugacuccuu cuccaggagc                                                   20


<210>  37029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37029
ccaggagcug uguucagacu                                                   20


<210>  37030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37030
gacuuucgca gcucuuggcu                                                   20


<210>  37031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37031
cagcucuugg cuuggagcuc                                                   20


<210>  37032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37032
uccucucuca cugucgaccu                                                   20


<210>  37033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37033
ugaccagucc auuaaauaag                                                   20


<210>  37034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37034
agaccagccu ggccaacaug                                                   20


<210>  37035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37035
ccauguuggc caggcugguc                                                   20


<210>  37036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37036
ccugccucag ccucccaagu                                                   20


<210>  37037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37037
agcuguucuc cugccucagc                                                   20


<210>  37038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37038
gguuucaagc uguucuccug                                                   20


<210>  37039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37039
gcuuagaaaa aucagaauuu                                                   20


<210>  37040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37040
aagcagaaac agauauccua                                                   20


<210>  37041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37041
gauuuuucua agcagaaaca                                                   20


<210>  37042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37042
aaaugccagg uguucugaau                                                   20


<210>  37043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37043
gaauacguaa guaugggaga                                                   20


<210>  37044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37044
gaacaccugg cauuuagaaa                                                   20


<210>  37045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37045
uuuuuaugua aaaucuucgc                                                   20


<210>  37046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37046
cguagccaug uggcacugga                                                   20


<210>  37047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37047
ucucggucca gugccacaug                                                   20


<210>  37048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37048
ccuuaacuuu guuucuagga                                                   20


<210>  37049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37049
aggaauguuc cggagaauca                                                   20


<210>  37050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37050
uagaaacaaa guuaaggaga                                                   20


<210>  37051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37051
ggagaaucac agcagcugcc                                                   20


<210>  37052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37052
ccggaacauu ccuagaaaca                                                   20


<210>  37053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37053
gcagugaugg cuguggcggc                                                   20


<210>  37054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37054
acacccugga cagcuugaac                                                   20


<210>  37055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37055
agcuguccag gguguagaaa                                                   20


<210>  37056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37056
augaucacca cccacccggc                                                   20


<210>  37057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37057
gcccaccagc gguagucggu                                                   20


<210>  37058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37058
gggucugcug cacuucugcc                                                   20


<210>  37059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37059
uaaugcccca cagcccaggg                                                   20


<210>  37060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37060
uuuuccauuu uuugugaggg                                                   20


<210>  37061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37061
auuuuuugug agggcuugug                                                   20


<210>  37062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37062
caagcccuca caaaaaaugg                                                   20


<210>  37063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37063
gcugcauauu aauauuccuu                                                   20


<210>  37064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37064
uuucauggac agcauauuau                                                   20


<210>  37065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37065
uggacagcau auuauuggga                                                   20


<210>  37066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37066
aaauagcagu ugcuuucuaa                                                   20


<210>  37067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37067
aaaugcgauu uucuuuggca                                                   20


<210>  37068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37068
uuggcagguu cuuugacacc                                                   20


<210>  37069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37069
uugacaccau ugcaucuugu                                                   20


<210>  37070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37070
aguccuuaaa uugguuccau                                                   20


<210>  37071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37071
auagccagac auguugcaau                                                   20


<210>  37072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37072
gguuauccuu agauaaugaa                                                   20


<210>  37073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37073
uuaucuaagg auaaccagaa                                                   20


<210>  37074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37074
aaaccucuug gaaauguuau                                                   20


<210>  37075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37075
aagagguuuu gaaauuugcu                                                   20


<210>  37076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37076
aaaaggcuua cuaagguucu                                                   20


<210>  37077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37077
cguuaugggu ggcccucuuu                                                   20


<210>  37078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37078
ggcuuaagcu ccauuucuag                                                   20


<210>  37079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37079
aggugcucca acacuccauu                                                   20


<210>  37080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37080
auacauauac aaauaaugga                                                   20


<210>  37081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37081
gcugggcggg ggccaggguu                                                   20


<210>  37082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37082
ggaaggcuca agaucccacg                                                   20


<210>  37083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37083
agaaauacug ugcugaggau                                                   20


<210>  37084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37084
ccagcguggg aucuugagcc                                                   20


<210>  37085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37085
uuuccccagc gugggaucuu                                                   20


<210>  37086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37086
ggagacaaaa gagggcaggu                                                   20


<210>  37087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37087
uggcacucag cuggaaaguc                                                   20


<210>  37088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37088
agcugagugc caugaacugg                                                   20


<210>  37089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37089
uaaccaucca cucugugccg                                                   20


<210>  37090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37090
guuggaggag acagaccagu                                                   20


<210>  37091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37091
aaugucguca cuggucuguc                                                   20


<210>  37092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37092
gucuccugcc cccacagugc                                                   20


<210>  37093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37093
gugcugcuuu aacgugcaua                                                   20


<210>  37094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37094
augcacguua aagcagcaca                                                   20


<210>  37095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37095
gcagaucacu ccuuuucuga                                                   20


<210>  37096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37096
gacagauggg ccugcuuacu                                                   20


<210>  37097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37097
gauauaacau cagaguaagc                                                   20


<210>  37098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37098
gagcuuucug auauaacauc                                                   20


<210>  37099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37099
cagauucaga gcuuucugau                                                   20


<210>  37100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37100
ggggacacaa uucccagauu                                                   20


<210>  37101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37101
guuacuccaa uucaggggac                                                   20


<210>  37102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37102
uuuaaacacu caucaucuaa                                                   20


<210>  37103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37103
aaacuaaauu uaccuuuggu                                                   20


<210>  37104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37104
gcaagcgucu ucauucagcc                                                   20


<210>  37105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37105
uucagcccuc ugagggcaaa                                                   20


<210>  37106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37106
gcccucugag ggcaaacuac                                                   20


<210>  37107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37107
gugacuguuu cgugaccccc                                                   20


<210>  37108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37108
ugacccccuc ugauccaguu                                                   20


<210>  37109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37109
uuuauaaccu ucuguauugu                                                   20


<210>  37110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37110
guauuguucc uucuauuauc                                                   20


<210>  37111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37111
uucuauuauc cugaaauaac                                                   20


<210>  37112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37112
auuauccuga aauaacauua                                                   20


<210>  37113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37113
ggauaauaga aggaacaaua                                                   20


<210>  37114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37114
caaggugcug ggauuauagg                                                   20


<210>  37115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37115
agaccagccu ggccaacaug                                                   20


<210>  37116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37116
ucauguuggc caggcugguc                                                   20


<210>  37117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37117
guagagacag cauuucauca                                                   20


<210>  37118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37118
gaguagcagg gacuacaggc                                                   20


<210>  37119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37119
cccgccucag ccuucugagu                                                   20


<210>  37120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37120
agcgauucuc ccgccucagc                                                   20


<210>  37121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37121
uccuagguuc aagcgauucu                                                   20


<210>  37122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37122
aaaaauaucg uucuuuaaug                                                   20


<210>  37123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37123
uuaaugguaa uguaaaggua                                                   20


<210>  37124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37124
accacgggga caccuuagac                                                   20


<210>  37125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37125
uuccaccacg gggacaccuu                                                   20


<210>  37126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37126
gguuuaaacc ccugcucuua                                                   20


<210>  37127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37127
agcugugggu ggugggggau                                                   20


<210>  37128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37128
augagaugag aaaaaugaau                                                   20


<210>  37129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37129
caucucaugg aaauaaaaag                                                   20


<210>  37130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37130
uuuuucucau cucauggaaa                                                   20


<210>  37131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37131
aguaauucau uuuucucauc                                                   20


<210>  37132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37132
cacuucuagu aauucauuuu                                                   20


<210>  37133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37133
gcaacuggau acagcaauuu                                                   20


<210>  37134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37134
ugcugcuuac ucuugacccu                                                   20


<210>  37135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37135
cucucaaucu gucuuaccuc                                                   20


<210>  37136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37136
ccaagaggua agacagauug                                                   20


<210>  37137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37137
cagcucaucu uguucugagu                                                   20


<210>  37138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37138
gagucacccu agauuuggga                                                   20


<210>  37139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37139
uucgccacca guaccgggcg                                                   20


<210>  37140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37140
ccaccaguac cgggcggugu                                                   20


<210>  37141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37141
gccccaauuu guagcagcac                                                   20


<210>  37142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37142
uuaugucuac ugcucauauu                                                   20


<210>  37143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37143
aauaugagca guagacauaa                                                   20


<210>  37144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37144
cuuucagagg cucauuaccc                                                   20


<210>  37145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37145
gaggcucauu acccuauagc                                                   20


<210>  37146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37146
cagugggccg uccugccagc                                                   20


<210>  37147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37147
uguucguuag uuuucacauu                                                   20


<210>  37148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37148
uuaguuuuca cauugacaca                                                   20


<210>  37149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37149
cauugacaca uaauuuacaa                                                   20


<210>  37150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37150
aucaacugua gucaguaaca                                                   20


<210>  37151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37151
aacaguuccc ucuuccucug                                                   20


<210>  37152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37152
cucuuccucu gccacauccu                                                   20


<210>  37153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37153
ucugccacau ccugccccuc                                                   20


<210>  37154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37154
gcccauugca gaaggccaua                                                   20


<210>  37155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37155
gcaaugggcu gaacagaggg                                                   20


<210>  37156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37156
auggccuucu gcaaugggcu                                                   20


<210>  37157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37157
auuucuaugg ccuucugcaa                                                   20


<210>  37158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37158
gccucucaaa auacugggau                                                   20


<210>  37159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37159
agacuagccu gggcugccua                                                   20


<210>  37160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37160
ggagaugggg ucuugcuagg                                                   20


<210>  37161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37161
gcugcuuggg aggcugaggc                                                   20


<210>  37162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37162
ccagagacaa cgucuugcug                                                   20


<210>  37163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37163
uuuuucccca gagacaacgu                                                   20


<210>  37164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37164
uucuuuuuuc cccagagaca                                                   20


<210>  37165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37165
guuucuuucu uuuuucccca                                                   20


<210>  37166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37166
gagucuggcc ccuuucggug                                                   20


<210>  37167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37167
gugagcagug ucuaaaguuc                                                   20


<210>  37168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37168
gucgcguguu gcccacgcgu                                                   20


<210>  37169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37169
cuucaccagu ugggaaacag                                                   20


<210>  37170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37170
ccaguuggga aacagagaaa                                                   20


<210>  37171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37171
caacugguga agugaaaaca                                                   20


<210>  37172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37172
cuguuuccca acuggugaag                                                   20


<210>  37173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37173
acagauuuaa acuuuuuaaa                                                   20


<210>  37174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37174
cuucuaaauc cugagggauu                                                   20


<210>  37175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37175
aaauccugag ggauuacagg                                                   20


<210>  37176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37176
uguaaucccu caggauuuag                                                   20


<210>  37177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37177
gaauauucuu agcuugaugu                                                   20


<210>  37178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37178
gaaauacaac aacuuuuccu                                                   20


<210>  37179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37179
uagcuugaug ugaccucugu                                                   20


<210>  37180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37180
cauugcggca aagggccuua                                                   20


<210>  37181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37181
gggucugacc gagcgacguc                                                   20


<210>  37182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37182
cacguauuca aaaagaaaaa                                                   20


<210>  37183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37183
aaaagaaaaa aacaauaaag                                                   20


<210>  37184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37184
uuuugaauac gugggaauua                                                   20


<210>  37185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37185
cacuuuauug uuuuuuucuu                                                   20


<210>  37186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37186
cucuacacug acuucucacu                                                   20


<210>  37187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37187
ccacuaacac agguuauuuc                                                   20


<210>  37188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37188
uccccacuaa cacagguuau                                                   20


<210>  37189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37189
auaacguaua acaucaacau                                                   20


<210>  37190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37190
uugggaaacg aacaguaaaa                                                   20


<210>  37191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37191
caaugaaaca ucaccacucu                                                   20


<210>  37192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37192
uuucccaaug aaacaucacc                                                   20


<210>  37193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37193
uguuuuacug uucguuuccc                                                   20


<210>  37194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37194
uucuggcagu uggcaacuuu                                                   20


<210>  37195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37195
ggcaguuggc aacuuucacg                                                   20


<210>  37196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37196
cggcagaugg agaauuucaa                                                   20


<210>  37197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37197
ccaucugccg ugaaaguugc                                                   20


<210>  37198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37198
aaagcaauug cucaauuauc                                                   20


<210>  37199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37199
gaaauaaagg ugcugauuga                                                   20


<210>  37200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37200
gaacucacac uggcuauguu                                                   20


<210>  37201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37201
aucagcaccu uuauuucaga                                                   20


<210>  37202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37202
ggcaagcauu uuaauuuucu                                                   20


<210>  37203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37203
gccuguuaaa uucuguuuuc                                                   20


<210>  37204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37204
guuuucuuua guuuuucaua                                                   20


<210>  37205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37205
uuaguuuuuc auaugugguu                                                   20


<210>  37206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37206
uaugugguuu auuguagcuu                                                   20


<210>  37207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37207
uaagcuacaa uaaaccacau                                                   20


<210>  37208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37208
gauauggcaa uauuuaaaac                                                   20


<210>  37209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37209
aaaacagaca aguuguuuua                                                   20


<210>  37210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37210
aguucuaaaa cagacaaguu                                                   20


<210>  37211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37211
guauuuugca aauaagcuca                                                   20


<210>  37212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37212
ggauggcagu gagcuuauuu                                                   20


<210>  37213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37213
agaagacaca gucuguccag                                                   20


<210>  37214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37214
agaaggagca acagaugcau                                                   20


<210>  37215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37215
ccagacaucu ggggacuaag                                                   20


<210>  37216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37216
gacuuggcag ccaaacuugg                                                   20


<210>  37217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37217
aaguuuggcu gccaagucag                                                   20


<210>  37218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37218
cuauugcaca uuccaaguuu                                                   20


<210>  37219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37219
uacuauuucu cuauugcaca                                                   20


<210>  37220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37220
cuucugugau uaugucguaa                                                   20


<210>  37221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37221
gugauuaugu cguaaguuug                                                   20


<210>  37222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37222
aacuuacgac auaaucacag                                                   20


<210>  37223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37223
ccuggucccc accucccuca                                                   20


<210>  37224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37224
agagggucca ugcaaguguc                                                   20


<210>  37225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37225
auggagcuug gcaggacacc                                                   20


<210>  37226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37226
agauuuaguu ucgauggagc                                                   20


<210>  37227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37227
uucuagauuu aguuucgaug                                                   20


<210>  37228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37228
gcugugacau auaauuggag                                                   20


<210>  37229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37229
agucacugga uucuaaguug                                                   20


<210>  37230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37230
aaguuggacu gugagaguuu                                                   20


<210>  37231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37231
cucaaauuaa caaacauacc                                                   20


<210>  37232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37232
auugcuuccc ucaaauuaac                                                   20


<210>  37233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37233
gauuuuaaau uuuuuuaaaa                                                   20


<210>  37234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37234
agcaacucga gaggcugagg                                                   20


<210>  37235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37235
uaccucagcc ucucgaguug                                                   20


<210>  37236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37236
caaagagcug ugauuacagg                                                   20


<210>  37237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37237
agaccagccu ggcaacacag                                                   20


<210>  37238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37238
cuguguugcc aggcuggucu                                                   20


<210>  37239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37239
uuuuuuggua gaggcagggu                                                   20


<210>  37240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37240
ucucuuucuu uuuuugguag                                                   20


<210>  37241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37241
uccucucuuu cuuuuuuugg                                                   20


<210>  37242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37242
uucuuccucu cuuucuuuuu                                                   20


<210>  37243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37243
cagucucuca gguggcuggg                                                   20


<210>  37244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37244
gggcucaagc aauccucccu                                                   20


<210>  37245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37245
acaaauuaac uuaaaaaaau                                                   20


<210>  37246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37246
uugucacauu uuaugaugga                                                   20


<210>  37247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37247
uguuuaaaug ccguucucuu                                                   20


<210>  37248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37248
cuuuaaagaa aaaaaaauaa                                                   20


<210>  37249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37249
uuaaagagaa cggcauuuaa                                                   20


<210>  37250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37250
ccaugguaaa uaugugaugc                                                   20


<210>  37251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37251
uccguuuauu uguuuuuuug                                                   20


<210>  37252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37252
auauuuauau uaaaaauauu                                                   20


<210>  37253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37253
uugucacaaa caugguaucu                                                   20


<210>  37254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37254
gaaucagaaa aggaagccga                                                   20


<210>  37255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37255
gaauauuuaa cacuguuuug                                                   20


<210>  37256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37256
gauucagaau auuuaacacu                                                   20


<210>  37257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37257
uuuucugauu cagaauauuu                                                   20


<210>  37258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37258
guuggagagu cggcuuccuu                                                   20


<210>  37259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37259
ggugaugaca auuuauuaau                                                   20


<210>  37260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37260
cuauugaagu aguuuuucua                                                   20


<210>  37261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37261
auagagaaag uaaagcaaaa                                                   20


<210>  37262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37262
auuuuguucu acuuuuaagg                                                   20


<210>  37263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37263
acuuuuaagg auaauauaau                                                   20


<210>  37264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37264
cagaaauaua agaaaaaaga                                                   20


<210>  37265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37265
gugaaaaaca gcauuauaaa                                                   20


<210>  37266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37266
uauauuucug ugaaaaacag                                                   20


<210>  37267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37267
gauuuuugga uuugggauga                                                   20


<210>  37268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37268
gaagcuuuuu gagugcugac                                                   20


<210>  37269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37269
gaauuuggag cauuuuggau                                                   20


<210>  37270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37270
aaggaaaugu ucauuggaag                                                   20


<210>  37271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37271
uuugaacaua augucagcac                                                   20


<210>  37272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37272
uuggaagguu ucagauuuuc                                                   20


<210>  37273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37273
aaugaacauu uccuuugaac                                                   20


<210>  37274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37274
gauuuucgga uuuagggagc                                                   20


<210>  37275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37275
gauuuaggga gcucaacaaa                                                   20


<210>  37276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37276
aaaccugaaa aaaauccuaa                                                   20


<210>  37277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37277
gguuuugaaa uaugugcauu                                                   20


<210>  37278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37278
gaauacuucu gaucccaaac                                                   20


<210>  37279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37279
gaauuuagga uuuuuuucag                                                   20


<210>  37280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37280
gaucccaaac auuucagaua                                                   20


<210>  37281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37281
gauaaggguu auucaaccug                                                   20


<210>  37282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37282
accuguacug ucagaugauc                                                   20


<210>  37283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37283
uuugggauca ucugacagua                                                   20


<210>  37284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37284
uugauauuug guuaacgauu                                                   20


<210>  37285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37285
gccuaggauu augaaucaag                                                   20


<210>  37286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37286
uaauccuagg cagaaacugu                                                   20


<210>  37287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37287
ucuugauuca uaauccuagg                                                   20


<210>  37288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37288
uauaaaucuu aaauaucuac                                                   20


<210>  37289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37289
uauuuuggau ucaacaguuc                                                   20


<210>  37290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37290
acaguucugu caaaacugug                                                   20


<210>  37291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37291
gucaaaacug uggcagugau                                                   20


<210>  37292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37292
uuuuuuccca cugaacuauc                                                   20


<210>  37293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37293
cacugaacua ucacaaaauu                                                   20


<210>  37294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37294
gugggaaaaa aagaaucccc                                                   20


<210>  37295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37295
aauuuuguga uaguucagug                                                   20


<210>  37296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37296
ccaauuacuc uuuuuccaau                                                   20


<210>  37297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37297
ggccggcuaa gccagugggg                                                   20


<210>  37298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37298
ccagggggcc uaacuucaca                                                   20


<210>  37299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37299
cacagccucu gccgcagugc                                                   20


<210>  37300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37300
uaccuccuca auuauuugug                                                   20


<210>  37301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37301
ccuucuuacc cuuucuggcc                                                   20


<210>  37302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37302
uacccuuucu ggccuuucua                                                   20


<210>  37303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37303
ggccuuucua uggcauuaau                                                   20


<210>  37304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37304
auggcauuaa uaccuggucu                                                   20


<210>  37305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37305
uguguacuug aaaaugaauc                                                   20


<210>  37306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37306
aguacacaag aagagaccag                                                   20


<210>  37307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37307
uuuucaagua cacaagaaga                                                   20


<210>  37308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37308
uuagugucag aaccuccaug                                                   20


<210>  37309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37309
gacacuaagg aaaaauauga                                                   20


<210>  37310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37310
agaucugauc agccuuuccc                                                   20


<210>  37311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37311
cacgagccuc caguacagga                                                   20


<210>  37312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37312
ucagugccgu ucaucggaac                                                   20


<210>  37313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37313
ucggaacucu gcugccagcg                                                   20


<210>  37314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37314
gaugaacggc acugaugaag                                                   20


<210>  37315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37315
uccaggcaau ucagucucgu                                                   20


<210>  37316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37316
gucucguugu gaaaaccuuu                                                   20


<210>  37317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37317
caacgagacu gaauugccug                                                   20


<210>  37318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37318
acuguacguc uucauccugc                                                   20


<210>  37319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37319
uccugccgac uauugccagu                                                   20


<210>  37320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37320
cugccuuaaa aauggaguau                                                   20


<210>  37321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37321
auacuccauu uuuaaggcag                                                   20


<210>  37322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37322
gauuugcaaa auagucaucu                                                   20


<210>  37323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37323
uuuccuucuu gcuguuagcc                                                   20


<210>  37324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37324
uucuugcugu uagccaacca                                                   20


<210>  37325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37325
ugcuguuagc caaccaugcu                                                   20


<210>  37326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37326
gcaugguugg cuaacagcaa                                                   20


<210>  37327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37327
ucagcauggu uggcuaacag                                                   20


<210>  37328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37328
gugcuuggag gggauccauc                                                   20


<210>  37329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37329
gugcaccccu uuccgugugc                                                   20


<210>  37330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37330
gugugcuggc ucgcaugguc                                                   20


<210>  37331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37331
acccggcgac aagcaaggau                                                   20


<210>  37332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37332
ggcugcaaau uuacagguau                                                   20


<210>  37333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37333
caauaccugu aaauuugcag                                                   20


<210>  37334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37334
cuucccaaua ccuguaaauu                                                   20


<210>  37335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37335
auauaaauca auaucagggu                                                   20


<210>  37336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37336
uccguaagua uggucuugac                                                   20


<210>  37337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37337
aucggugacc augucaagac                                                   20


<210>  37338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37338
auguuucuau cggugaccau                                                   20


<210>  37339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37339
uguauuuuuu ucuagucugc                                                   20


<210>  37340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37340
agucugcccu uacuaggaug                                                   20


<210>  37341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37341
uccuaguaag ggcagacuag                                                   20


<210>  37342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37342
uccuuuuuaa augagcauga                                                   20


<210>  37343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37343
auuggcaacu gggccaugcu                                                   20


<210>  37344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37344
uccauuggca acugggccau                                                   20


<210>  37345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37345
guugaguucu uccauuggca                                                   20


<210>  37346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37346
uggauucugu ugaguucuuc                                                   20


<210>  37347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37347
gagcagcggg cucgcucaga                                                   20


<210>  37348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37348
agcauuaccu cugagcgagc                                                   20


<210>  37349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37349
cguacaaauc uauauccuuu                                                   20


<210>  37350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37350
caggacaaga aaucgaugug                                                   20


<210>  37351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37351
uguccuguga auuuauuccc                                                   20


<210>  37352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37352
gcaguaaacc caccuauaag                                                   20


<210>  37353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37353
auuauggcac uucugcagua                                                   20


<210>  37354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37354
uacuuuuaaa acaaccagau                                                   20


<210>  37355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37355
aaagaguaaa ggaugaccgg                                                   20


<210>  37356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37356
aaaugcuacc ucucaaacag                                                   20


<210>  37357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37357
cuguccugug augaguggga                                                   20


<210>  37358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37358
cacucaucac aggacaguga                                                   20


<210>  37359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37359
aagcauuuaa ucauuuaguu                                                   20


<210>  37360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37360
caaagacuuu gcaaacacaa                                                   20


<210>  37361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37361
gacaaaggcu ucucaaagac                                                   20


<210>  37362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37362
augacugcag aauaaguuaa                                                   20


<210>  37363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37363
gcagucaugg aaauacacuc                                                   20


<210>  37364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37364
uucccuugcg gggcggggug                                                   20


<210>  37365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37365
cuugcggggc gggguggggg                                                   20


<210>  37366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37366
cugcugucuc ucucucccuc                                                   20


<210>  37367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37367
ccuucucugc ugucucucuc                                                   20


<210>  37368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37368
gcucaaagua cacagcauga                                                   20


<210>  37369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37369
uuuuuugcag uuucagcuca                                                   20


<210>  37370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37370
gucuuuagag uaccuugucu                                                   20


<210>  37371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37371
gucuuuagag uaccuuguug                                                   20


<210>  37372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37372
gucuguaggg ccaagcucuu                                                   20


<210>  37373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37373
uaaugcaaau uacaaaagag                                                   20


<210>  37374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37374
guccagauga gggagauuaa                                                   20


<210>  37375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37375
aaauaaaauc accucaucug                                                   20


<210>  37376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37376
uggucauuuc aaaauaaaau                                                   20


<210>  37377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37377
uaucaguugu cuuacuggga                                                   20


<210>  37378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37378
acuaucaaau aucccaguaa                                                   20


<210>  37379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37379
uaauaaaugu aaaacagauc                                                   20


<210>  37380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37380
uuuauacuca aacacugcaa                                                   20


<210>  37381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37381
ggaaaauauu aauggaguac                                                   20


<210>  37382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37382
agaaauuuca uuuauacuca                                                   20


<210>  37383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37383
caucaauacu caaacagguc                                                   20


<210>  37384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37384
cagcuaucuu cucaucaaua                                                   20


<210>  37385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37385
ucacagcuau cuucucauca                                                   20


<210>  37386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37386
uuuaagaagc cacuaauagu                                                   20


<210>  37387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37387
uaaaggaaaa uacacuuguu                                                   20


<210>  37388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37388
agaauccuag ugugcagagu                                                   20


<210>  37389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37389
agaaauauac acucuaagga                                                   20


<210>  37390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37390
uuuuuauuug uauuuuagac                                                   20


<210>  37391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37391
cugcuggaca gguuucgucu                                                   20


<210>  37392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37392
ucucuccacc augcaagacu                                                   20


<210>  37393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37393
cacccgcugg acggggaugg                                                   20


<210>  37394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37394
agugacacgu gcccaucccc                                                   20


<210>  37395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37395
ggcgcucggc ucggcucagu                                                   20


<210>  37396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37396
cugagccgag ccgagcgcca                                                   20


<210>  37397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37397
cccacuaacu acucacccca                                                   20


<210>  37398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37398
uugauucacc cacuaacuac                                                   20


<210>  37399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37399
agcacauguc aaugccguua                                                   20


<210>  37400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37400
ggccaccugu gaguugcacu                                                   20


<210>  37401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37401
gguauguugu cagcaccucc                                                   20


<210>  37402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37402
uggacaaagu ucagcuuaug                                                   20


<210>  37403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37403
gcuuaugaau augaauuuag                                                   20


<210>  37404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37404
uaagcugaac uuuguccagg                                                   20


<210>  37405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37405
uauucauaag cugaacuuug                                                   20


<210>  37406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37406
aaaaccagca gcccaaguau                                                   20


<210>  37407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37407
uauacuuggg cugcugguuu                                                   20


<210>  37408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37408
cuuucuuaua cuugggcugc                                                   20


<210>  37409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37409
guccugccuu cuuaggcucu                                                   20


<210>  37410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37410
uaggcucuau ucgcuaagca                                                   20


<210>  37411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37411
cuaagcaccu gcccugcccu                                                   20


<210>  37412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37412
aaauauagcu aaaccacuaa                                                   20


<210>  37413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37413
aauaggccuu ccaaauauag                                                   20


<210>  37414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37414
ccaggugaag ggggaggcug                                                   20


<210>  37415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37415
ccuggugaac uuccaauagg                                                   20


<210>  37416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37416
guuaccugcc ugggcacccu                                                   20


<210>  37417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37417
ccuuuggacu ucuguuaccu                                                   20


<210>  37418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37418
caagcacugg ccuaggccug                                                   20


<210>  37419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37419
caucccugga gcuacaggcc                                                   20


<210>  37420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37420
aggggacuuc acaucccugg                                                   20


<210>  37421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37421
ccuuauccau uuuuuucuuc                                                   20


<210>  37422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37422
ucccaggacu gguacguuca                                                   20


<210>  37423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37423
caggacuggu acguucaucu                                                   20


<210>  37424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37424
ucuugucaaa ucccaguguu                                                   20


<210>  37425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37425
gcacugcugg aaggugcaga                                                   20


<210>  37426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37426
agcagugcag aaucugaccu                                                   20


<210>  37427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37427
ccagcucugc accuuccagc                                                   20


<210>  37428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37428
ugcugaagau augaaugccu                                                   20


<210>  37429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37429
gcaggaaucc gauucaccag                                                   20


<210>  37430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37430
uaucuucagc aggaauccga                                                   20


<210>  37431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37431
ugaugaacuc gguacggggg                                                   20


<210>  37432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37432
ucaugaaggc auucauaucu                                                   20


<210>  37433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37433
uugccuccac ugcucccccc                                                   20


<210>  37434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37434
ugugacuucc aagugggauu                                                   20


<210>  37435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37435
aagugggauu ugucucauca                                                   20


<210>  37436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37436
gaguggaguc ucuccgacau                                                   20


<210>  37437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37437
cggccccauu cagaguggag                                                   20


<210>  37438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37438
gauggggucg ggacaugggg                                                   20


<210>  37439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37439
gucucgauca gcauaacccc                                                   20


<210>  37440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37440
gccacauuag aauccacgga                                                   20


<210>  37441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37441
aauguggcug aaacaaugug                                                   20


<210>  37442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37442
aaacaacacc uccguggauu                                                   20


<210>  37443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37443
caucccaaac cauacaccca                                                   20


<210>  37444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37444
uccaguggag gccagauagu                                                   20


<210>  37445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37445
gucuuggcca uggagcuuag                                                   20


<210>  37446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37446
auucugucuu ggccauggag                                                   20


<210>  37447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37447
acacaguguc guaaugcgug                                                   20


<210>  37448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37448
agugucuugg aaguugaucu                                                   20


<210>  37449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37449
aagacacuag aaacaaguua                                                   20


<210>  37450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37450
ucuacucaca ccucuguuag                                                   20


<210>  37451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37451
ucacccccca accccagaug                                                   20


<210>  37452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37452
ccccccaacc ccagauguca                                                   20


<210>  37453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37453
ucucagaccu acuaggacgg                                                   20


<210>  37454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37454
cagaccuacu aggacgggag                                                   20


<210>  37455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37455
cccguccuag uaggucugag                                                   20


<210>  37456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37456
cucccauuug cugcauauca                                                   20


<210>  37457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37457
ugaaaagaga ccuugugggg                                                   20


<210>  37458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37458
ugaacaccug ccgucacucc                                                   20


<210>  37459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37459
gauguacuga agagcucaac                                                   20


<210>  37460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37460
guacaucaga acacacuguu                                                   20


<210>  37461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37461
guugagcucu ucaguacauc                                                   20


<210>  37462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37462
ccuguuguuu ucaguugagc                                                   20


<210>  37463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37463
uacgauucuc cugccucagc                                                   20


<210>  37464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37464
ccugccucag ccucccaaau                                                   20


<210>  37465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37465
ccauguuggc caggcugguc                                                   20


<210>  37466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37466
ugcagugaaa gcuaacuuac                                                   20


<210>  37467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37467
cugcaugaau cuuaagauaa                                                   20


<210>  37468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37468
aaauuugcua auugggcuuu                                                   20


<210>  37469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37469
aagcccaauu agcaaauuug                                                   20


<210>  37470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37470
gacuguaaaa gaaagcuuca                                                   20


<210>  37471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37471
uuuacaguca gaacuuuuac                                                   20


<210>  37472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37472
acuuuuggca uucaugaugc                                                   20


<210>  37473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37473
ugaugcuuuu cugaguauua                                                   20


<210>  37474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37474
gaguauuaaa cuaagauaga                                                   20


<210>  37475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37475
gguaaaacau cuaucuuagu                                                   20


<210>  37476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37476
uaugucaauu uggauuaugu                                                   20


<210>  37477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37477
aaccaaaauu uuggcauuca                                                   20


<210>  37478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37478
uauggcuacu uuuacguauu                                                   20


<210>  37479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37479
gcugcauuug aacaucuuuu                                                   20


<210>  37480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37480
aaugcagcug aaauacguaa                                                   20


<210>  37481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37481
aacuuuaggg ugguuggugu                                                   20


<210>  37482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37482
uaaaaacaaa aucaaagcua                                                   20


<210>  37483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37483
agcaaaucca agagcauaaa                                                   20


<210>  37484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37484
cucuuaguau uuuaaguaau                                                   20


<210>  37485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37485
acauaugcuu aguaaaauau                                                   20


<210>  37486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37486
uucaacauau gcuuaguaaa                                                   20


<210>  37487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37487
aauauuuaua acaggcauag                                                   20


<210>  37488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37488
acucuaugcc uguuauaaau                                                   20


<210>  37489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37489
uaaaaauauu uuugauggua                                                   20


<210>  37490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37490
cagaaacauu ugccuuauuc                                                   20


<210>  37491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37491
gagaaaauac aaauugguau                                                   20


<210>  37492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37492
uuuuucuguu guguuuuucu                                                   20


<210>  37493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37493
guuguguuuu ucuuaccuga                                                   20


<210>  37494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37494
uaccugauug aaagcucaua                                                   20


<210>  37495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37495
aucagguaag aaaaacacaa                                                   20


<210>  37496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37496
ggaguucaac cuaagccugc                                                   20


<210>  37497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37497
accuaagccu gcuagcucca                                                   20


<210>  37498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37498
cucaucccua ggcuuaagca                                                   20


<210>  37499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37499
gguggccaga agagugcccu                                                   20


<210>  37500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37500
ggccaccaga aauuucacuc                                                   20


<210>  37501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37501
aaaagggcac ucuucuggcc                                                   20


<210>  37502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37502
agcccgagcu gccugcagag                                                   20


<210>  37503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37503
acuugcucca guaggccgcc                                                   20


<210>  37504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37504
agggccagua uaguacuuug                                                   20


<210>  37505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37505
auguauuaga uccacugccu                                                   20


<210>  37506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37506
gagccgagga cacccgugcu                                                   20


<210>  37507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37507
uccugugugu uugccacuuu                                                   20


<210>  37508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37508
uguguguuug ccacuuugcc                                                   20


<210>  37509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37509
uugacauggu cauggacaua                                                   20


<210>  37510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37510
ucaagggcuu agagcccuau                                                   20


<210>  37511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37511
ucaguggcac aucuacacau                                                   20


<210>  37512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37512
ucagauucuc agagaauugc                                                   20


<210>  37513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37513
cagagaauug cuugacugcc                                                   20


<210>  37514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37514
cugagaaucu gaugaaagcu                                                   20


<210>  37515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37515
aaguugaugc aucugugcuc                                                   20


<210>  37516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37516
aaaggcaguc aagcaauucu                                                   20


<210>  37517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37517
guuucagggg augcugcacu                                                   20


<210>  37518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37518
ggggaugcug cacuguauca                                                   20


<210>  37519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37519
uccugagaaa gagaaggaca                                                   20


<210>  37520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37520
caggaggaag gugcaaauga                                                   20


<210>  37521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37521
cuuucucagg aggaaggugc                                                   20


<210>  37522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37522
caauguccuu cucuuucuca                                                   20


<210>  37523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37523
ugguggcaac ccuugaggua                                                   20


<210>  37524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37524
gugucagccc caugcccccu                                                   20


<210>  37525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37525
aauaaaacug cuuuacccuc                                                   20


<210>  37526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37526
aucucagccu ggcaguaagu                                                   20


<210>  37527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37527
cccucaccuc gccacuccuc                                                   20


<210>  37528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37528
caucugcacc uaccauguua                                                   20


<210>  37529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37529
ugucucuaaa auuaggaucc                                                   20


<210>  37530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37530
agaugauuau uuuucauguc                                                   20


<210>  37531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37531
uuggcugaca uguccaggcc                                                   20


<210>  37532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37532
cccccagaau guguacacgu                                                   20


<210>  37533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37533
gggggcgaau uacaagcacu                                                   20


<210>  37534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37534
ggaugcauua aagucuggcc                                                   20


<210>  37535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37535
uuggugugag guggaggcgg                                                   20


<210>  37536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37536
gaaccacgug gagucauaug                                                   20


<210>  37537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37537
gaauaagggu guauuuauca                                                   20


<210>  37538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37538
gguuucagcu uaguggggaa                                                   20


<210>  37539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37539
gcuuaguggg gaagugggaa                                                   20


<210>  37540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37540
ccacuaagcu gaaaccugaa                                                   20


<210>  37541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37541
cacuucccca cuaagcugaa                                                   20


<210>  37542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37542
uccugcauac agcaggcaca                                                   20


<210>  37543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37543
ucaccuguca aaugggagua                                                   20


<210>  37544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37544
cuaagccuug cuuuccucac                                                   20


<210>  37545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37545
gugacuugcc cagguccucu                                                   20


<210>  37546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37546
uagcucagag gaccugggca                                                   20


<210>  37547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37547
ggcauuugaa cccaaggccu                                                   20


<210>  37548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37548
aaugccagaa uggcuacuuc                                                   20


<210>  37549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37549
agggauagca ggccuugggu                                                   20


<210>  37550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37550
accuaugaca gaggcaagcc                                                   20


<210>  37551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37551
uuggggcucc cacagcacca                                                   20


<210>  37552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37552
acaggagccc acagcgcuga                                                   20


<210>  37553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37553
gcgcuguggg cuccuguaga                                                   20


<210>  37554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37554
ccaaagugcc aguccccucu                                                   20


<210>  37555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37555
guccugaccc accuauuccc                                                   20


<210>  37556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37556
ggaagggcaa gggcaccugg                                                   20


<210>  37557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37557
agaaggacag cucugacaug                                                   20


<210>  37558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37558
acaacuguga uucacacggc                                                   20


<210>  37559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37559
cacggcuucc ccaaacgaag                                                   20


<210>  37560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37560
ccaaacgaag guacacgagu                                                   20


<210>  37561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37561
uuuggggaag ccgugugaau                                                   20


<210>  37562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37562
gugacucggu acuucccuuu                                                   20


<210>  37563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37563
cuuuaggccc uguccuggca                                                   20


<210>  37564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37564
uccuggaggc cggugagucc                                                   20


<210>  37565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37565
uggacgggga cucaccggcc                                                   20


<210>  37566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37566
uaucauaguu ccugucugcu                                                   20


<210>  37567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37567
ugucugcuuc accauguuuu                                                   20


<210>  37568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37568
ccauguuuuu auuuugugcu                                                   20


<210>  37569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37569
uagcuuagua ccuggcaaac                                                   20


<210>  37570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37570
ugaugcauau uuuaucuacc                                                   20


<210>  37571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37571
aguguagacu ccaauauauu                                                   20


<210>  37572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37572
aguuaaauuc caguguagac                                                   20


<210>  37573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37573
aaaucuaaau aaaaugacua                                                   20


<210>  37574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37574
gcuuucauca aaaauaccuc                                                   20


<210>  37575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37575
ucaaaaauac cucuaaacuu                                                   20


<210>  37576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37576
gaagauuauu uguuuucugu                                                   20


<210>  37577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37577
gaauguaaug uuauuaaucu                                                   20


<210>  37578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37578
gucagaguua aaauguuugu                                                   20


<210>  37579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37579
uuucaaggaa caguauccuc                                                   20


<210>  37580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37580
aggaacagua uccucaacaa                                                   20


<210>  37581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37581
uugaaaagaa caagccacuu                                                   20


<210>  37582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37582
aaacgcccuc uaacauguaa                                                   20


<210>  37583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37583
uguuucauaa uuguuuucau                                                   20


<210>  37584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37584
uaauuguuuu caucugugca                                                   20


<210>  37585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37585
ucugugcauu uguagccaac                                                   20


<210>  37586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37586
aguuggcuac aaaugcacag                                                   20


<210>  37587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37587
uggagguuau agugaugauu                                                   20


<210>  37588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37588
aagucccucg acugucuccu                                                   20


<210>  37589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37589
gauuucuaag ucccucgacu                                                   20


<210>  37590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37590
uucagauuuc uaagucccuc                                                   20


<210>  37591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37591
gauuucauuc agauuucuaa                                                   20


<210>  37592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37592
aaucuucaga cauauaccac                                                   20


<210>  37593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37593
gacauauacc acuaaccaag                                                   20


<210>  37594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37594
aaggaaucua ggcuagucug                                                   20


<210>  37595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37595
uuagaaccaa uuuuagacaa                                                   20


<210>  37596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37596
acuuuuguga ggcugcacaa                                                   20


<210>  37597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37597
acauuuuaca uuugugcagc                                                   20


<210>  37598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37598
aucagugcuu uuuauucaac                                                   20


<210>  37599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37599
acacacuucc aucagugcuu                                                   20


<210>  37600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37600
ucucuuuguu cuguuguaau                                                   20


<210>  37601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37601
cuuuguucug uuguaauuuu                                                   20


<210>  37602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37602
guuguaauuu uaguugcagu                                                   20


<210>  37603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37603
uaguccagaa agaaggacaa                                                   20


<210>  37604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37604
ggacuaagaa gcugcucucc                                                   20


<210>  37605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37605
uucuggacua agaagcugcu                                                   20


<210>  37606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37606
uccuccuccu cgcugauggc                                                   20


<210>  37607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37607
uacauguugu uccuccagga                                                   20


<210>  37608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37608
uccaggacuu aaaaaucauu                                                   20


<210>  37609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37609
cagagacgug caccgcggug                                                   20


<210>  37610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37610
aggaguccac acucaccgcg                                                   20


<210>  37611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37611
gagugaacac cuuauccgua                                                   20


<210>  37612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37612
cucggaaaca aaagagcugg                                                   20


<210>  37613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37613
ccccgcacuu cccacacucu                                                   20


<210>  37614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37614
cacacucugc aguuauucug                                                   20


<210>  37615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37615
gagauccuug agggcaggga                                                   20


<210>  37616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37616
cugcccucaa ggaucucaga                                                   20


<210>  37617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37617
uuguguucuc agaaauuaau                                                   20


<210>  37618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37618
cagaaauuaa ugcucggccu                                                   20


<210>  37619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37619
gagaacacaa agaagacaaa                                                   20


<210>  37620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37620
uuaucacuca acaaaagguu                                                   20


<210>  37621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37621
cacaugagua uucaguaacc                                                   20


<210>  37622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37622
guaaccucag ugucagguuc                                                   20


<210>  37623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37623
gccaucuguu uugguggaua                                                   20


<210>  37624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37624
uuuaaauauc caccaaaaca                                                   20


<210>  37625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37625
gcuuuuccua cagaaaaaaa                                                   20


<210>  37626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37626
uacagaaaaa aaaaaaaauc                                                   20


<210>  37627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37627
guaggaaaag cggaauuuuc                                                   20


<210>  37628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37628
ugcacuuucc ucccaauucu                                                   20


<210>  37629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37629
ucccaauucu agaguaggua                                                   20


<210>  37630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37630
agaguaggua uuuuacuagg                                                   20


<210>  37631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37631
uaguaaaaua ccuacucuag                                                   20


<210>  37632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37632
ucccaacagg cacugccacc                                                   20


<210>  37633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37633
uuggccaagu gucuuuuguu                                                   20


<210>  37634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37634
ugccagggcc ccuaggcugc                                                   20


<210>  37635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37635
gcuucuuuag cccagugucu                                                   20


<210>  37636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37636
uuagcccagu gucugguggg                                                   20


<210>  37637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37637
ccaccagaca cugggcuaaa                                                   20


<210>  37638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37638
augcucugug gcucaggaaa                                                   20


<210>  37639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37639
ugagccacag agcauggaaa                                                   20


<210>  37640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37640
aucaugagug caccagugcu                                                   20


<210>  37641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37641
ccccgcuuuu gugcaauccu                                                   20


<210>  37642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37642
ugucuuuagu cuucugcaua                                                   20


<210>  37643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37643
gcauaguacu uuucucuucu                                                   20


<210>  37644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37644
cuucugguuc ccgguucaag                                                   20


<210>  37645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37645
gguucccggu ucaagguuuu                                                   20


<210>  37646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37646
cgguucaagg uuuuguaauu                                                   20


<210>  37647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37647
agguuuugua auuagagaau                                                   20


<210>  37648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37648
cuaauuacaa aaccuugaac                                                   20


<210>  37649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37649
gggucauucu cuaauuacaa                                                   20


<210>  37650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37650
cugaauuugu aucucaaacc                                                   20


<210>  37651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37651
gagaaguccu uggcugugca                                                   20


<210>  37652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37652
ggcuucaguu ugugauuuca                                                   20


<210>  37653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37653
guuugugauu ucaugauuuc                                                   20


<210>  37654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37654
ugauuucuug uugcuaccua                                                   20


<210>  37655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37655
uguugcuacc uaaggaauau                                                   20


<210>  37656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37656
uuagguagca acaagaaauc                                                   20


<210>  37657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37657
uauuccuuag guagcaacaa                                                   20


<210>  37658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37658
agccgagugg caccucaggc                                                   20


<210>  37659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37659
guggugagga uaagaauagu                                                   20


<210>  37660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37660
uauccucacc acagaagcac                                                   20


<210>  37661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37661
auccacacgg uuggcacuau                                                   20


<210>  37662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37662
aggugcuuua cauggaggga                                                   20


<210>  37663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37663
uaacaagacu gucauccguu                                                   20


<210>  37664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37664
auugcuuuaa aacaguugag                                                   20


<210>  37665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37665
gggcccguug cucuaacuca                                                   20


<210>  37666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37666
guuuggguga agaugauuau                                                   20


<210>  37667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37667
cccaaacaga acccacuuca                                                   20


<210>  37668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37668
ccauggcccu cuuuaggcaa                                                   20


<210>  37669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37669
cacucuugcc uaaagagggc                                                   20


<210>  37670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37670
uuguuuuuuu aaucaccucg                                                   20


<210>  37671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37671
uaaaggucau ccaauaaaua                                                   20


<210>  37672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37672
ccguuuuagc ugggaugguc                                                   20


<210>  37673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37673
ccugccucag ccucccaagu                                                   20


<210>  37674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37674
cgccauucuc cugccucagc                                                   20


<210>  37675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37675
cauuggacuu aagcaauuaa                                                   20


<210>  37676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37676
cuauccuagg aaguugccca                                                   20


<210>  37677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37677
uaggauagag aaggacuucu                                                   20


<210>  37678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37678
acaguuuggg caacuuccua                                                   20


<210>  37679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37679
agacucaaga caccauucug                                                   20


<210>  37680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37680
guggaucuuc ccaagggugu                                                   20


<210>  37681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37681
caagggugug aaguguccac                                                   20


<210>  37682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37682
cacccuuggg aagauccaca                                                   20


<210>  37683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37683
augcccacca gaaccaugcc                                                   20


<210>  37684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37684
ggugggcaug gaaacuccca                                                   20


<210>  37685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37685
uaggucagag ugcuugaggg                                                   20


<210>  37686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37686
cuggcuuucc uaggucagag                                                   20


<210>  37687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37687
cuggucuccc aggaccugug                                                   20


<210>  37688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37688
uuuaggacac cuccucugcc                                                   20


<210>  37689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37689
agcugucaca ggcugcugcu                                                   20


<210>  37690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37690
cagcccucug gcccacucuc                                                   20


<210>  37691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37691
ggaccauucc agcaauccca                                                   20


<210>  37692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37692
agcaauccca gcagaaaaug                                                   20


<210>  37693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37693
gcugggauug cuggaauggu                                                   20


<210>  37694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37694
ccccauuuuc ugcugggauu                                                   20


<210>  37695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37695
uauccgccua uaccauacaa                                                   20


<210>  37696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37696
accuucauau ccgccuauac                                                   20


<210>  37697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37697
guggccaacu cagagucuaa                                                   20


<210>  37698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37698
acaguuacag cuugagcagc                                                   20


<210>  37699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37699
acacugggca uauaggaugu                                                   20


<210>  37700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37700
gccaccaucu cacaggcugc                                                   20


<210>  37701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37701
uuuuaugacc caaggccaac                                                   20


<210>  37702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37702
cacgccauug cuaaggaaca                                                   20


<210>  37703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37703
uuagcaaugg cgugagaaac                                                   20


<210>  37704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37704
uugcagaaga ccaaguacgg                                                   20


<210>  37705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37705
gcaaggaacg agcagacuca                                                   20


<210>  37706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37706
ccguacuugg ucuucugcaa                                                   20


<210>  37707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37707
gucccgcccu cucacgugug                                                   20


<210>  37708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37708
ggugcccacu gugguucugg                                                   20


<210>  37709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37709
ggugccaggc ugcuuuccuc                                                   20


<210>  37710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37710
ucaggcacca cguguggagg                                                   20


<210>  37711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37711
acuagcgacc uccacacgug                                                   20


<210>  37712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37712
aaaaugaacu gaggcccuac                                                   20


<210>  37713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37713
uuuuagaaaa cccaguauuu                                                   20


<210>  37714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37714
agagcaacua gaccacuuug                                                   20


<210>  37715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37715
ggucugcuau uaagcaaagu                                                   20


<210>  37716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37716
uuuggagaua auucauguuu                                                   20


<210>  37717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37717
uguuuuucua cacaguuuug                                                   20


<210>  37718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37718
acacaguuuu gcaguugucu                                                   20


<210>  37719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37719
gaauugguuu aaaguaggug                                                   20


<210>  37720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37720
gaagacaacu gcaaaacugu                                                   20


<210>  37721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37721
caaagugcug ggauuacagg                                                   20


<210>  37722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37722
agaccagccu ggccaacaug                                                   20


<210>  37723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37723
ccauguuggc caggcugguc                                                   20


<210>  37724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37724
ccugucucag ucuccugagu                                                   20


<210>  37725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37725
agcgauucuc cugucucagu                                                   20


<210>  37726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37726
ccuccugggu ucaagcgauu                                                   20


<210>  37727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37727
gaucaauaac accuaccuuu                                                   20


<210>  37728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37728
gauaacauga ggagcuuagc                                                   20


<210>  37729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37729
gcccagugaa auggcaucau                                                   20


<210>  37730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37730
cugggcagaa gucagucccc                                                   20


<210>  37731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37731
gcgggcuggu gggagaugau                                                   20


<210>  37732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37732
uuagggccug cagcauccuc                                                   20


<210>  37733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37733
ugccugagga ugcugcaggc                                                   20


<210>  37734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37734
uuccugccug aggaugcugc                                                   20


<210>  37735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37735
cccugaccua caccugcugg                                                   20


<210>  37736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37736
cugggaccug gcuccauucu                                                   20


<210>  37737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37737
caggcagcca caagccucuu                                                   20


<210>  37738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37738
gccgcaggga augaagguau                                                   20


<210>  37739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37739
cugcggcaga auccuuaucu                                                   20


<210>  37740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37740
uucccugcgg cagaauccuu                                                   20


<210>  37741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37741
agauggcggg cuuauuccga                                                   20


<210>  37742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37742
gaagaagagg ccagugccug                                                   20


<210>  37743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37743
gaauaagccc gccaucugga                                                   20


<210>  37744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37744
ucggaauaag cccgccaucu                                                   20


<210>  37745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37745
agcaccgcca ggcacuggcc                                                   20


<210>  37746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37746
gcaacugcuu ccagcaccgc                                                   20


<210>  37747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37747
ugggaagaga gcagcagggg                                                   20


<210>  37748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37748
caggaaagcc uacaacuccc                                                   20


<210>  37749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37749
ccagcacccc ugcugcucuc                                                   20


<210>  37750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37750
uuagcaucug guuaugagac                                                   20


<210>  37751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37751
uccagcaagc ucuucacugg                                                   20


<210>  37752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37752
cuggcauuga ggaguucccu                                                   20


<210>  37753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37753
cugagugcgg ucaucuggaa                                                   20


<210>  37754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37754
agaugaccgc acucagggaa                                                   20


<210>  37755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37755
uguggugagg uaagagauua                                                   20


<210>  37756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37756
cacagcccau cugcacaaag                                                   20


<210>  37757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37757
guuggguccu uugucaccuc                                                   20


<210>  37758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37758
gugaggugac aaaggaccca                                                   20


<210>  37759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37759
aguggcagga ucagcucacg                                                   20


<210>  37760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37760
ucugugcaug gcacuugucu                                                   20


<210>  37761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37761
gugcauggca cuugucugag                                                   20


<210>  37762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37762
cugugcguga ggugcucaga                                                   20


<210>  37763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37763
gaguuuacag aaauaagcug                                                   20


<210>  37764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37764
guaaacucug aaguccaguu                                                   20


<210>  37765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37765
uuuucaugcc ugcuugccaa                                                   20


<210>  37766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37766
ugccugcuug ccaauaaaca                                                   20


<210>  37767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37767
gcucagauau guuuauuggc                                                   20


<210>  37768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37768
augagguuca gcucagauau                                                   20


<210>  37769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37769
agcacagcac cugcuguuug                                                   20


<210>  37770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37770
cccagcacuc ccugaguggg                                                   20


<210>  37771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37771
uguccucauc cugaggcugc                                                   20


<210>  37772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37772
ccaucaagug gcccucccaa                                                   20


<210>  37773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37773
uuccccauca aguggcccuc                                                   20


<210>  37774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37774
ugggacuucc uuccccauca                                                   20


<210>  37775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37775
gggggagaag gugccagcuc                                                   20


<210>  37776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37776
cccccagaaa acagcuccaa                                                   20


<210>  37777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37777
cuccacuggg cucccuccuc                                                   20


<210>  37778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37778
ugcuuccuca caguaugucu                                                   20


<210>  37779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37779
ucacaguaug ucuguccuga                                                   20


<210>  37780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37780
uuuucaucuu cucaggugug                                                   20


<210>  37781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37781
ucuucucagg uguggaagcu                                                   20


<210>  37782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37782
caggugugga agcuuggaug                                                   20


<210>  37783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37783
acaccugaga agaugaaaag                                                   20


<210>  37784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37784
cugagauccc cguggaguuc                                                   20


<210>  37785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37785
uccaggaaaa ggaagucuuu                                                   20


<210>  37786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37786
uggaggaacu ccacggggau                                                   20


<210>  37787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37787
uuuuccugga ggaacuccac                                                   20


<210>  37788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37788
ucuaccgcau caacacacua                                                   20


<210>  37789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37789
ggucaccauu gucggacauc                                                   20


<210>  37790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37790
ucccgguaga uguccgacaa                                                   20


<210>  37791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37791
cauuugacuc cagaaaagau                                                   20


<210>  37792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37792
ggagucaaau gagaagaucc                                                   20


<210>  37793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37793
cauagguuug uauuauuauc                                                   20


<210>  37794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37794
caguauaaaa ggaguuuugc                                                   20


<210>  37795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37795
uguguuuugu ggcuugaauc                                                   20


<210>  37796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37796
agccacaaaa cacaggaacu                                                   20


<210>  37797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37797
gggcuuguuu gaagucagga                                                   20


<210>  37798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37798
aacaagcccg gaauacacaa                                                   20


<210>  37799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37799
ugacuucaaa caagcccgga                                                   20


<210>  37800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37800
uguguagugg acaacgugag                                                   20


<210>  37801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37801
gccuuagauu uugcauuuag                                                   20


<210>  37802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37802
gagacaagug cugccacugu                                                   20


<210>  37803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37803
uguguucacc agucugaucc                                                   20


<210>  37804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37804
ccagucugau ccuguugugu                                                   20


<210>  37805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37805
cauaugggaa caagcagacg                                                   20


<210>  37806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37806
cauaugagaa aauggaccac                                                   20


<210>  37807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37807
uggcacucgc cuuccccaga                                                   20


<210>  37808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37808
ccagagccua gaggcagcau                                                   20


<210>  37809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37809
ccccaugcug ccucuaggcu                                                   20


<210>  37810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37810
agcccuccua ccugagcagc                                                   20


<210>  37811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37811
uagaauuguu gcagauuuag                                                   20


<210>  37812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37812
augaaauaga cacgaccccc                                                   20


<210>  37813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37813
aaaucugcaa caauucuaug                                                   20


<210>  37814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37814
aaacaaaugu uaccccuuau                                                   20


<210>  37815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37815
aaauaagugu cuaaaugaau                                                   20


<210>  37816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37816
uuuagacacu uauuuagaaa                                                   20


<210>  37817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37817
cagugacugu gcccugcugu                                                   20


<210>  37818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37818
uggaauguuc cugucuuguc                                                   20


<210>  37819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37819
aggaaacacc acagcagggc                                                   20


<210>  37820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37820
ugucuugucc uagaaagucu                                                   20


<210>  37821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37821
aggacaagac aggaacauuc                                                   20


<210>  37822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37822
gcagauuuga ggcuuguuug                                                   20


<210>  37823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37823
gggauccaaa caagccucaa                                                   20


<210>  37824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37824
ccuuuauaau ucaaugucca                                                   20


<210>  37825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37825
auguccaaag agagcccuga                                                   20


<210>  37826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37826
uggcugugag gaucgguauc                                                   20


<210>  37827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37827
agagcaaggg cacccaagua                                                   20


<210>  37828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37828
uuguucauuu uuuucccugu                                                   20


<210>  37829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37829
uuuuuuuccc uguaacguaa                                                   20


<210>  37830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37830
cuguaacgua aauuguuaua                                                   20


<210>  37831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37831
gacacagaua cagacaaaua                                                   20


<210>  37832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37832
cucugucucu uguucuuucu                                                   20


<210>  37833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37833
uucuuuaccc cguuuaucac                                                   20


<210>  37834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37834
uuaccccguu uaucacgggg                                                   20


<210>  37835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37835
ccuguccuaa gcaccccauc                                                   20


<210>  37836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37836
uguccccauc augaugucug                                                   20


<210>  37837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37837
gacagcugug cuucaugucc                                                   20


<210>  37838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37838
uuagauacac ucgaaugcag                                                   20


<210>  37839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37839
aguguaucua acgaacaguu                                                   20


<210>  37840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37840
cugaaucccc guuccuaccu                                                   20


<210>  37841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37841
gugaaaauac auccgacaga                                                   20


<210>  37842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37842
uaccuugaua cacucuuuuu                                                   20


<210>  37843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37843
ucuagacagg ucagaggaac                                                   20


<210>  37844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37844
agacagguca gaggaaccau                                                   20


<210>  37845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37845
ucugaccugu cuagaagaau                                                   20


<210>  37846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37846
accucaauaa agcugcuaaa                                                   20


<210>  37847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37847
cauacuacag auuucaccca                                                   20


<210>  37848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37848
cccacucuaa gcggacagcu                                                   20


<210>  37849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37849
cuggagucca gcccugagac                                                   20


<210>  37850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37850
gccccacuca cuaaaugggc                                                   20


<210>  37851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37851
guuuccucaa ugaugaaaug                                                   20


<210>  37852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37852
ucaaugauga aauggagggg                                                   20


<210>  37853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37853
ucauugagga aaccgaagua                                                   20


<210>  37854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37854
ccgcaucaua gaacugugug                                                   20


<210>  37855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37855
augaugcggg gaacacuauc                                                   20


<210>  37856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37856
ccaggggccg ugcugugucg                                                   20


<210>  37857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37857
caagccugua acggagagcu                                                   20


<210>  37858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37858
aggcuggacc agucguacuc                                                   20


<210>  37859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37859
aacugaguac gacuggucca                                                   20


<210>  37860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37860
ucaaacugag uacgacuggu                                                   20


<210>  37861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37861
ggugggcucu ccuccugcuc                                                   20


<210>  37862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37862
ccaccaaagg ccugcaagcg                                                   20


<210>  37863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37863
uuuuuucucu uaccuuauuu                                                   20


<210>  37864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37864
cuuaccuuau uuuugaaaga                                                   20


<210>  37865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37865
aaaauaaggu aagagaaaaa                                                   20


<210>  37866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37866
gcuacucuuu caaaaauaag                                                   20


<210>  37867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37867
agagcaggga caaagccugc                                                   20


<210>  37868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37868
agccauuggu aaucgcagcc                                                   20


<210>  37869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37869
auguuaagga ucaauacgau                                                   20


<210>  37870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37870
ggaaaauauc uuuuaguuua                                                   20


<210>  37871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37871
agaaagggca caaucguauu                                                   20


<210>  37872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37872
gaggagugua gguugaauua                                                   20


<210>  37873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37873
accuacacuc cucugaauau                                                   20


<210>  37874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37874
uuuuaauuca accuacacuc                                                   20


<210>  37875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37875
uuuuucuaau gucuugcaga                                                   20


<210>  37876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37876
aaugucuugc agagauuuua                                                   20


<210>  37877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37877
ugaaguguuc acguacauua                                                   20


<210>  37878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37878
agaagccuga uaaaaucucu                                                   20


<210>  37879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37879
cguacauuac gcuaacacga                                                   20


<210>  37880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37880
gcuggcuccg cuguaccaga                                                   20


<210>  37881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37881
cauucugcug gcuccgcugu                                                   20


<210>  37882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37882
acaacuuccc auucugcugg                                                   20


<210>  37883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37883
gauagaaggu gugguuugaa                                                   20


<210>  37884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37884
aucagaauca agggccugca                                                   20


<210>  37885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37885
aaccacaccu ucuaucagaa                                                   20


<210>  37886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37886
gugaguucaa accacaccuu                                                   20


<210>  37887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37887
ugcauagaag cuaacagggu                                                   20


<210>  37888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37888
augcaugaau uuaaagacaa                                                   20


<210>  37889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37889
cucauacauu uuacaggccu                                                   20


<210>  37890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37890
aagauaauuu auuaaaaagu                                                   20


<210>  37891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37891
uguuuggagu uuugugccca                                                   20


<210>  37892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37892
aaucaaggac uccuuugggc                                                   20


<210>  37893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37893
gggcccgugu gugcggaggc                                                   20


<210>  37894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37894
gucaggcuga gcucacgggg                                                   20


<210>  37895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37895
ucccauugag gcagggaaga                                                   20


<210>  37896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37896
cugccucaau gggaggaaga                                                   20


<210>  37897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37897
gcaggcagag gugguugugg                                                   20


<210>  37898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37898
aggaagacac agagaggacc                                                   20


<210>  37899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37899
uggaaggaga gcccacaugu                                                   20


<210>  37900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37900
ggggcugcug cuccaagcag                                                   20


<210>  37901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37901
gaggcuuguu ccggggcugc                                                   20


<210>  37902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37902
cacgugucuc ugggacauag                                                   20


<210>  37903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37903
ccgcugaagc guccagcagc                                                   20


<210>  37904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37904
gcggggaacc cacugucccc                                                   20


<210>  37905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37905
accaggccgu uuuccuucau                                                   20


<210>  37906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37906
uucauugcua gaauugaaaa                                                   20


<210>  37907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37907
uugcuagaau ugaaaacacc                                                   20


<210>  37908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37908
agcaaugaag gaaaacggcc                                                   20


<210>  37909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37909
auucuagcaa ugaaggaaaa                                                   20


<210>  37910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37910
cacugaccag gaggccaccu                                                   20


<210>  37911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37911
agcuucucac ugaccaggag                                                   20


<210>  37912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37912
ugucacguuu ccagcuucuc                                                   20


<210>  37913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37913
ccuaaaugcu caauaacccc                                                   20


<210>  37914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37914
ugcucugcua acgucuuccc                                                   20


<210>  37915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37915
acuaguugcc ugcucauucc                                                   20


<210>  37916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37916
uaagugagca ccuguccgug                                                   20


<210>  37917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37917
uuugguauua caccagguuc                                                   20


<210>  37918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37918
uuuaggcaaa gcggagggaa                                                   20


<210>  37919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37919
cuccgcuuug ccuaaaggaa                                                   20


<210>  37920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37920
gguguuuuuc acuuguaaga                                                   20


<210>  37921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37921
cuuguaagau uuugaaggaa                                                   20


<210>  37922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37922
aaaucuuaca agugaaaaac                                                   20


<210>  37923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37923
uucaaaaucu uacaagugaa                                                   20


<210>  37924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37924
aaaauguagg uuugggagga                                                   20


<210>  37925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37925
ucccaaaccu acauuuuaga                                                   20


<210>  37926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37926
agcaaugguu ucaaagagag                                                   20


<210>  37927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37927
aagagagaga auauugccac                                                   20


<210>  37928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37928
cucucuuuga aaccauugcu                                                   20


<210>  37929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37929
cugucuccgg cuacuacagg                                                   20


<210>  37930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37930
cucagguacc uguaguagcc                                                   20


<210>  37931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37931
agcccaagua caaccgcucc                                                   20


<210>  37932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37932
cucauucuag cccaaguaca                                                   20


<210>  37933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37933
cgcaucacug guguggugag                                                   20


<210>  37934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37934
uaagcaggag ucuuagucag                                                   20


<210>  37935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37935
ucccugggcc ugacuaagac                                                   20


<210>  37936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37936
agauuuuacu uccucccugg                                                   20


<210>  37937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37937
uuuccagauu uuacuuccuc                                                   20


<210>  37938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37938
cauucauuuc cagauuuuac                                                   20


<210>  37939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37939
cuccugccag ucaagaaaug                                                   20


<210>  37940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37940
ugacuggcag gagagaaugc                                                   20


<210>  37941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37941
cauuucuuga cuggcaggag                                                   20


<210>  37942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37942
cuucucauuu cuugacuggc                                                   20


<210>  37943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37943
uucgcuucuc auuucuugac                                                   20


<210>  37944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37944
cacgggcugu aagaccagca                                                   20


<210>  37945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37945
acuuuuaaau ccugcugguc                                                   20


<210>  37946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37946
uaacauaagc aacuaauuca                                                   20


<210>  37947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37947
ucuacacaag cugaaucucc                                                   20


<210>  37948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37948
gcuuguguag augaacuugg                                                   20


<210>  37949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37949
uaagaaacca uguguggcag                                                   20


<210>  37950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37950
uaggaaaagc uggagauuca                                                   20


<210>  37951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37951
gguugugugc cugcccuauc                                                   20


<210>  37952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37952
uuuaaaccag gugacaagcu                                                   20


<210>  37953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37953
cucaaaagua uuuuagcgua                                                   20


<210>  37954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37954
guagcuauuu aggaguuuaa                                                   20


<210>  37955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37955
aggugcuuaa acuccuaaau                                                   20


<210>  37956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37956
gcaauuaaag ccuucaaggu                                                   20


<210>  37957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37957
auguggacgu gcaauguguu                                                   20


<210>  37958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37958
acgcccuaau aaacauuuga                                                   20


<210>  37959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37959
aggagcucau aagucaggag                                                   20


<210>  37960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37960
augacagguc auugcuccug                                                   20


<210>  37961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37961
gccuucuaug acaggucauu                                                   20


<210>  37962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37962
agggaagggg gcguggaggc                                                   20


<210>  37963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37963
cuggaagcac uugcuccccu                                                   20


<210>  37964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37964
cgggcaccag ccucccgcua                                                   20


<210>  37965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37965
gcugggcauc cccccaauuc                                                   20


<210>  37966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37966
caccccccca cgccccaggc                                                   20


<210>  37967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37967
ggaaggcacu guucaccaaa                                                   20


<210>  37968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37968
agaaccccac cucggugccc                                                   20


<210>  37969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37969
ccaaaaugcu uaucuggguc                                                   20


<210>  37970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37970
uauucacaga ggugggagcu                                                   20


<210>  37971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37971
cagagguggg agcugagggg                                                   20


<210>  37972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37972
cuaugacaaa uaagacugca                                                   20


<210>  37973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37973
caggugcccu caucagccac                                                   20


<210>  37974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37974
cguggcugau gagggcaccu                                                   20


<210>  37975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37975
guccucagac uuuggcgcuu                                                   20


<210>  37976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37976
ccugggugug ucaagcgcca                                                   20


<210>  37977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37977
uuuaaaaagu gcacugagcu                                                   20


<210>  37978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37978
uuucauuuaa aaagugcacu                                                   20


<210>  37979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37979
uuuuuuuuaa aaaaaaauuu                                                   20


<210>  37980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37980
uuguuuuuau cuguuuuauu                                                   20


<210>  37981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37981
uaggucccgc aagcagagga                                                   20


<210>  37982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37982
ucugcuugcg ggaccuagga                                                   20


<210>  37983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37983
guauuccaga aaguaguuaa                                                   20


<210>  37984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37984
agaaaguagu uaagagaccu                                                   20


<210>  37985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37985
ggaauacaga acauaaauaa                                                   20


<210>  37986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37986
gcugacucca cucuguccuc                                                   20


<210>  37987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37987
uccugagcau uucagcugac                                                   20


<210>  37988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37988
uggcgucuac uuccuccuga                                                   20


<210>  37989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37989
gggugggagc cccgugugca                                                   20


<210>  37990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37990
uagcagguca cauuggucug                                                   20


<210>  37991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37991
guuuccuccu cagauaagug                                                   20


<210>  37992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37992
uccucagaua agugaaggga                                                   20


<210>  37993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37993
cuuaucugag gaggaaacag                                                   20


<210>  37994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37994
agggucuggg ugugguggcu                                                   20


<210>  37995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37995
guuuacauuu uuuuuuaagg                                                   20


<210>  37996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37996
cuccaccccg gugcuguguc                                                   20


<210>  37997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37997
cucaccgggu uccugauuua                                                   20


<210>  37998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37998
ugauuuagug aaagcaguug                                                   20


<210>  37999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  37999
cuaaaucagg aacccgguga                                                   20


<210>  38000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38000
cuuuguagcu uuuguuucug                                                   20


<210>  38001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38001
guggaaaugg gucagaauau                                                   20


<210>  38002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38002
acagaaacaa aagcuacaaa                                                   20


<210>  38003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38003
gacccauuuc cacagaaaca                                                   20


<210>  38004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38004
aaacaccaua uucugaccca                                                   20


<210>  38005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38005
ucuucugagu uccuggccug                                                   20


<210>  38006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38006
gaguuccugg ccugcagccu                                                   20


<210>  38007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38007
uggccugcag ccuucacagc                                                   20


<210>  38008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38008
cagcagaaac ccugugaugu                                                   20


<210>  38009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38009
gcugugaagg cugcaggcca                                                   20


<210>  38010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38010
guucccugcu cucugccugu                                                   20


<210>  38011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38011
cugcucucug ccuguacugu                                                   20


<210>  38012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38012
gugacaggaa gcagggagcu                                                   20


<210>  38013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38013
ugucacugaa accggcaggc                                                   20


<210>  38014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38014
agacauaguu ggaaaaagaa                                                   20


<210>  38015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38015
aacuaugucu agaaaaauac                                                   20


<210>  38016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38016
uuuuccaacu augucuagaa                                                   20


<210>  38017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38017
guccuuucac cuuugacaga                                                   20


<210>  38018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38018
ccuuugacag auguuuccac                                                   20


<210>  38019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38019
accccaagau aagugaaaau                                                   20


<210>  38020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38020
cuuaucuugg gguggaaaca                                                   20


<210>  38021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38021
ugaaaguguu ucugaagggc                                                   20


<210>  38022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38022
ugaaaaauac agugcauccu                                                   20


<210>  38023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38023
gaagggcagg cugagaguga                                                   20


<210>  38024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38024
gaaacacuuu caugaaaaau                                                   20


<210>  38025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38025
cuaucccccc aaccccgcug                                                   20


<210>  38026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38026
auguuugcgu uguguccagc                                                   20


<210>  38027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38027
gccccaguau gaucccauga                                                   20


<210>  38028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38028
gccccagaca gggcaggggu                                                   20


<210>  38029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38029
gccccagaca gggcaggggu                                                   20


<210>  38030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38030
gccccagaca gggcaggggu                                                   20


<210>  38031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38031
gccccagaca gggcaggggu                                                   20


<210>  38032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38032
cugucugggg cugaaggaca                                                   20


<210>  38033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38033
gccccagaca gggaaggggu                                                   20


<210>  38034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38034
gccccagaca gggcaggggu                                                   20


<210>  38035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38035
gccccagaca gggcaggggu                                                   20


<210>  38036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38036
gccccagaca gggcaggggu                                                   20


<210>  38037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38037
gccccagaca gggcaggggu                                                   20


<210>  38038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38038
gccccagaca gggcaggggu                                                   20


<210>  38039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38039
gccccagaca gggcaggggu                                                   20


<210>  38040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38040
gccccagaca gggcaggggu                                                   20


<210>  38041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38041
gccccagaca gggcaggggu                                                   20


<210>  38042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38042
gccccagaca gggcaggggu                                                   20


<210>  38043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38043
gccccagaca gggcaggggu                                                   20


<210>  38044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38044
gccccagaca gggcaggggu                                                   20


<210>  38045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38045
gccccagaca gggcaggggu                                                   20


<210>  38046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38046
gccccagaca gggcaggggu                                                   20


<210>  38047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38047
caaaagcaag uagcggcuca                                                   20


<210>  38048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38048
uacagacucc ucgcccacuc                                                   20


<210>  38049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38049
ccccugggac ccagcacccu                                                   20


<210>  38050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38050
uggcaccaag ggccauuucc                                                   20


<210>  38051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38051
ccaucaucac uggcacuagc                                                   20


<210>  38052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38052
cgagaaccag gcagaaagga                                                   20


<210>  38053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38053
cgggaagccu cgagcacuug                                                   20


<210>  38054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38054
gccugguucu cgggaagccu                                                   20


<210>  38055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38055
agucucccgc acuggcaguc                                                   20


<210>  38056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38056
uuuuccaguc ucccgcacug                                                   20


<210>  38057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38057
guguuuuggg gacuccauuc                                                   20


<210>  38058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38058
gaugucacuu aggagugaaa                                                   20


<210>  38059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38059
cuccuaagug acaucugaau                                                   20


<210>  38060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38060
uagagccucu uucuguguca                                                   20


<210>  38061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38061
gugucacccu ccucagcugc                                                   20


<210>  38062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38062
ugccuuuagc augugcugga                                                   20


<210>  38063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38063
cagcagcugu ccagccccug                                                   20


<210>  38064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38064
gacaccccag guuacgggca                                                   20


<210>  38065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38065
guggcaggug uccauacacu                                                   20


<210>  38066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38066
ccagccacac ggaguguaug                                                   20


<210>  38067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38067
uccucccuca ggggugugau                                                   20


<210>  38068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38068
ucgucccauu ccuccucccu                                                   20


<210>  38069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38069
ucaccaccca cgucuccagu                                                   20


<210>  38070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38070
aauggccuuu uucuuuuuaa                                                   20


<210>  38071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38071
uuuuaacaga aauuugaaau                                                   20


<210>  38072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38072
guuaaaaaga aaaaggccau                                                   20


<210>  38073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38073
aauuucuguu aaaaagaaaa                                                   20


<210>  38074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38074
uaucagucau uugauuuguu                                                   20


<210>  38075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38075
ugaaaugagc cucucaucuc                                                   20


<210>  38076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38076
agaagcaccu caaacaaauc                                                   20


<210>  38077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38077
aaguacauga gaugagaggc                                                   20


<210>  38078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38078
acaggaaaca ccgggcugga                                                   20


<210>  38079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38079
uguggaauau gcgagauggg                                                   20


<210>  38080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38080
caguuuuugc uugaguugua                                                   20


<210>  38081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38081
cauuccccuc acaccugcac                                                   20


<210>  38082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38082
ccucacaccu gcacgugcca                                                   20


<210>  38083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38083
uacacccaag agacauuacu                                                   20


<210>  38084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38084
ggaugcguug ccuggauucu                                                   20


<210>  38085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38085
aacagcgcga uucuccccuu                                                   20


<210>  38086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38086
ccccuugccc uccugguuuu                                                   20


<210>  38087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38087
acaucuccag cuucuagugg                                                   20


<210>  38088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38088
aguggucuca gacuuguuca                                                   20


<210>  38089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38089
ccgagcgcaa ccaguuugag                                                   20


<210>  38090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38090
gucagcguca cauacaucag                                                   20


<210>  38091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38091
caguucuguc agcgucacau                                                   20


<210>  38092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38092
gaagacgaga uccucgcuca                                                   20


<210>  38093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38093
gaagggugca cccuucgcag                                                   20


<210>  38094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38094
gugcugaagc cacgggggcc                                                   20


<210>  38095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38095
gcacagaaac cucugugcca                                                   20


<210>  38096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38096
aagaguugac ccgaaccgga                                                   20


<210>  38097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38097
ggucaacucu uggaaggagg                                                   20


<210>  38098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38098
cagauggagg ggguucagcg                                                   20


<210>  38099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38099
gcgacgguca gugccauuca                                                   20


<210>  38100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38100
caggucacug ugaugugggu                                                   20


<210>  38101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38101
guggggaugg gcuacuacaa                                                   20


<210>  38102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38102
accaucuacg augccucagc                                                   20


<210>  38103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38103
ccaugcucug cccugaggcc                                                   20


<210>  38104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38104
caguuauguu ccaggccccc                                                   20


<210>  38105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38105
aggccccccg agcuuccugg                                                   20


<210>  38106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38106
uggcuggaca gcuucucucc                                                   20


<210>  38107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38107
cuccuggggg ccguuuuguc                                                   20


<210>  38108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38108
agucccaaau cugggugcua                                                   20


<210>  38109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38109
acuguuuaua aauuacccag                                                   20


<210>  38110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38110
caccguucug ggggcuggaa                                                   20


<210>  38111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38111
gggggcugga aguuuucaug                                                   20


<210>  38112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38112
agcccccaga acggugagaa                                                   20


<210>  38113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38113
uggucaaggu gccagcagau                                                   20


<210>  38114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38114
uagauggcau cuucuggcug                                                   20


<210>  38115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38115
ggcugggucc ucacggugga                                                   20


<210>  38116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38116
accgugagga cccagccaga                                                   20


<210>  38117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38117
cuccuuccac cgugaggacc                                                   20


<210>  38118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38118
aaaaggccug agggagcuug                                                   20


<210>  38119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38119
uguacugugg cacugcaaau                                                   20


<210>  38120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38120
ggagggauag aaacauucag                                                   20


<210>  38121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38121
aucccuccug aaacuccuac                                                   20


<210>  38122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38122
gaccauccca gcggucaagu                                                   20


<210>  38123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38123
uccucuugag uuccuccuua                                                   20


<210>  38124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38124
uccuuauucu gcuucugguu                                                   20


<210>  38125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38125
gcuucugguu uaucaggauu                                                   20


<210>  38126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38126
gguuuaucag gauucagcca                                                   20


<210>  38127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38127
gccagugcag caugguaccu                                                   20


<210>  38128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38128
guggcacauc accacauggu                                                   20


<210>  38129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38129
cgugugcagg ugauggauac                                                   20


<210>  38130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38130
ccagaugucg ggacccacgg                                                   20


<210>  38131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38131
aggauggcag aacugucaga                                                   20


<210>  38132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38132
gccauccuug aauaugcuuc                                                   20


<210>  38133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38133
uugucaugug gcauuaccua                                                   20


<210>  38134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38134
auugcuauca uaaaauggau                                                   20


<210>  38135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38135
ucaacaaaca ccugaguggc                                                   20


<210>  38136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38136
acaaacaccu gaguggcugc                                                   20


<210>  38137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38137
caccaagggc cccagacggc                                                   20


<210>  38138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38138
ugacacacag gagcccgucc                                                   20


<210>  38139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38139
ccgucaugac agcauugucg                                                   20


<210>  38140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38140
ucccgcaccc ccaccugaca                                                   20


<210>  38141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38141
cuugugggug uccuucagcc                                                   20


<210>  38142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38142
gccuggugcc augcugguga                                                   20


<210>  38143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38143
acucccugga cggcugcuga                                                   20


<210>  38144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38144
cugugugggc aucucucuuc                                                   20


<210>  38145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38145
cggcgaacac ccucugggug                                                   20


<210>  38146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38146
ccgugaagag agaugcccac                                                   20


<210>  38147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38147
aagagccgcu uugacaucgu                                                   20


<210>  38148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38148
ccuuuguggg aaguuucagc                                                   20


<210>  38149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38149
cacaaaggag aaggaccccu                                                   20


<210>  38150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38150
gcugcugggc uaacuugaau                                                   20


<210>  38151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38151
aguuagccca gcagcugaaa                                                   20


<210>  38152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38152
cauuugauua cugauggcac                                                   20


<210>  38153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38153
aaaugauuau uucucauuug                                                   20


<210>  38154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38154
ggaagauggc cauccucugu                                                   20


<210>  38155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38155
agaaagcaug agugcacaaa                                                   20


<210>  38156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38156
cagaggaugg ccaucuucca                                                   20


<210>  38157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38157
gcgcgucaug cuugguaccc                                                   20


<210>  38158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38158
caacgguggg caaauaccuc                                                   20


<210>  38159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38159
gaagugggac cuggggccgu                                                   20


<210>  38160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38160
gaaagcccca caucaggacc                                                   20


<210>  38161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38161
ugggccccca ccucacccug                                                   20


<210>  38162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38162
uucuugggcc cccaccucac                                                   20


<210>  38163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38163
uuguggguca cuuccuucuu                                                   20


<210>  38164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38164
ugggauggcu gggaguggcu                                                   20


<210>  38165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38165
gugucguccg gccauuuccc                                                   20


<210>  38166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38166
ccugcggaga ggcuccuacc                                                   20


<210>  38167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38167
cggcaguggu aggagccucu                                                   20


<210>  38168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38168
acaaaaacaa gaggccgccu                                                   20


<210>  38169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38169
cauggagcgc uggauggcca                                                   20


<210>  38170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38170
guguccccau agucuugggc                                                   20


<210>  38171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38171
gcccaagacu auggggacac                                                   20


<210>  38172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38172
uugcugacuu cugcaggggu                                                   20


<210>  38173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38173
gcaggggucu ccucacuguu                                                   20


<210>  38174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38174
aucugcucuu uaacagugag                                                   20


<210>  38175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38175
cuuucaaucu gcucuuuaac                                                   20


<210>  38176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38176
ucacuuucaa ucugcucuuu                                                   20


<210>  38177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38177
cuuaguaucc aaaaccuagc                                                   20


<210>  38178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38178
accaaaaugg ccucaauuuc                                                   20


<210>  38179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38179
gucaacuuca accaaaaugg                                                   20


<210>  38180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38180
agaaagacuc ucagcuaaga                                                   20


<210>  38181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38181
agaaaagccu gggguagucu                                                   20


<210>  38182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38182
uugcugauuu uguuuugugu                                                   20


<210>  38183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38183
agaauccucu cccagcgggg                                                   20


<210>  38184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38184
ggaagcucaa gccugguguc                                                   20


<210>  38185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38185
uggcgacgac acugcacacg                                                   20


<210>  38186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38186
cuccgggagu ccagagucug                                                   20


<210>  38187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38187
cagcaccaac ccuggugccc                                                   20


<210>  38188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38188
gcacacaagc gugagggcag                                                   20


<210>  38189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38189
gguuggagag gagauagucg                                                   20


<210>  38190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38190
gagacccccg ccccagcccc                                                   20


<210>  38191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38191
cagcucauuc ugagaccccc                                                   20


<210>  38192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38192
uucacagcuc auucugagac                                                   20


<210>  38193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38193
cacugauacc uggccugcca                                                   20


<210>  38194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38194
ucgggcaccu ccagcgagcu                                                   20


<210>  38195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38195
ugacucugcu cucgaggcca                                                   20


<210>  38196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38196
cugcucccag aacccuguua                                                   20


<210>  38197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38197
gggagcagag aaugagagcc                                                   20


<210>  38198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38198
ccgcccuggc ccaguaccuc                                                   20


<210>  38199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38199
acugugauuc cgaccucacc                                                   20


<210>  38200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38200
gaccucaccu uaucuuaaag                                                   20


<210>  38201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38201
guacacacgu guccuugaca                                                   20


<210>  38202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38202
cagcgauguc uuacaagcgc                                                   20


<210>  38203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38203
aaagucgcag aggcuuuagc                                                   20


<210>  38204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38204
gcacacggga gcugucuuua                                                   20


<210>  38205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38205
acccucccuc uaaagacagc                                                   20


<210>  38206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38206
ucagccaccc acauggggga                                                   20


<210>  38207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38207
ugcccucaac ucccccaugu                                                   20


<210>  38208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38208
caucuuugcu ccuaauucuu                                                   20


<210>  38209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38209
ucccagaccc cuucccaucu                                                   20


<210>  38210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38210
ugcccacuug ucaaagggga                                                   20


<210>  38211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38211
acucaacuuu gaccuagccc                                                   20


<210>  38212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38212
cgucucccuc caggucuucc                                                   20


<210>  38213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38213
gacaggaggg aggugugagc                                                   20


<210>  38214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38214
cgccugucau ccuugcuggg                                                   20


<210>  38215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38215
ggggcugccc cccaaaauca                                                   20


<210>  38216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38216
auggcucuug cugugggcau                                                   20


<210>  38217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38217
cugaguccuc caugcccaca                                                   20


<210>  38218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38218
accuggaugc cacaagcucu                                                   20


<210>  38219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38219
caguggccac ucauucaguc                                                   20


<210>  38220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38220
gucccuggcu accagguccu                                                   20


<210>  38221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38221
ccauggcaca gugaggaccu                                                   20


<210>  38222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38222
gugauccccc gacagcgccg                                                   20


<210>  38223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38223
uggcacaugc caucaugacg                                                   20


<210>  38224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38224
uucauggcac augccaucau                                                   20


<210>  38225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38225
ugagugcccu gugcuuuucc                                                   20


<210>  38226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38226
cacaccccag gccagucccc                                                   20


<210>  38227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38227
ucucucuguc ccucaacgag                                                   20


<210>  38228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38228
gccucugcuu gaccacuccc                                                   20


<210>  38229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38229
cagcaugucc ggccccacgc                                                   20


<210>  38230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38230
gcugcgugaa cauucacagc                                                   20


<210>  38231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38231
cgcagcugaa aacgggagac                                                   20


<210>  38232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38232
cagccagcag cacguacugg                                                   20


<210>  38233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38233
caaugaggua aaacgcagug                                                   20


<210>  38234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38234
ggcccuacgu ccagaggaua                                                   20


<210>  38235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38235
gcaucaauaa uacaggugag                                                   20


<210>  38236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38236
ucugcacacg gggagugggc                                                   20


<210>  38237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38237
cuucucuuuu ccuugcagga                                                   20


<210>  38238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38238
cuuuuccuug caggaucaua                                                   20


<210>  38239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38239
uugcaggauc auaccagugg                                                   20


<210>  38240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38240
ugccuccucc cgaccaaguc                                                   20


<210>  38241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38241
uugacacaga ggccuuucuc                                                   20


<210>  38242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38242
cccugugcag augugugggg                                                   20


<210>  38243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38243
agacagcauc accccacaca                                                   20


<210>  38244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38244
gcauccaggc gggagagcug                                                   20


<210>  38245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38245
cucuguccac acucagcuug                                                   20


<210>  38246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38246
agggaggcag gagcaugcuc                                                   20


<210>  38247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38247
cacuucuggu guugccccaa                                                   20


<210>  38248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38248
gguguugccc caagccggcc                                                   20


<210>  38249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38249
ugcaagguga uggggccggc                                                   20


<210>  38250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38250
gaucuccagg gacucacugg                                                   20


<210>  38251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38251
uacugaacac uuuuguuaca                                                   20


<210>  38252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38252
guacgaaggu uaccucuaua                                                   20


<210>  38253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38253
uguaacaaaa guguucagua                                                   20


<210>  38254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38254
ccuuuccugu aacaaaagug                                                   20


<210>  38255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38255
acccggacug acuuucuccu                                                   20


<210>  38256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38256
gacccuaauc cugcagcccc                                                   20


<210>  38257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38257
uuuugauagg uaagaagcga                                                   20


<210>  38258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38258
uaccuaucaa aaagaacaga                                                   20


<210>  38259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38259
cuucuuaccu aucaaaaaga                                                   20


<210>  38260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38260
cuagaacuuu ggccugaagc                                                   20


<210>  38261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38261
agggaagcua acggcugagg                                                   20


<210>  38262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38262
ggccaaaguu cuagggaagc                                                   20


<210>  38263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38263
ccaccacagc cugaccaugg                                                   20


<210>  38264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38264
acuggcgagc uggugguccu                                                   20


<210>  38265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38265
aagguugucc cagugccugc                                                   20


<210>  38266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38266
ugcccccugc cacaccccca                                                   20


<210>  38267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38267
gccccacccu cccagaggcu                                                   20


<210>  38268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38268
uccuccugcc gcugcuccuc                                                   20


<210>  38269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38269
accuucaucc uccugccgcu                                                   20


<210>  38270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38270
gccccccacc accccccacu                                                   20


<210>  38271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38271
augcacgcac agcagugggg                                                   20


<210>  38272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38272
cucaccugcu cuggaagugg                                                   20


<210>  38273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38273
agagcaggug agggaagcca                                                   20


<210>  38274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38274
caaggacaag ggccccugau                                                   20


<210>  38275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38275
caagagcaua cucaggugga                                                   20


<210>  38276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38276
gaacagccaa gccugugcug                                                   20


<210>  38277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38277
gaaugccuca ucuggucaaa                                                   20


<210>  38278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38278
uguugauuuu uuuuuuucuu                                                   20


<210>  38279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38279
uuucuuuuug agauggaguu                                                   20


<210>  38280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38280
uuuugagaug gaguuuuucc                                                   20


<210>  38281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38281
cuugucaccc aggcuggagu                                                   20


<210>  38282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38282
agugauucuc cugccucagc                                                   20


<210>  38283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38283
ccugccucag ccucccuagu                                                   20


<210>  38284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38284
ccguguuggc ugggcugguc                                                   20


<210>  38285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38285
agaccagccc agccaacacg                                                   20


<210>  38286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38286
ggaguucgag accagcccag                                                   20


<210>  38287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38287
ucagucccca uaugcucacu                                                   20


<210>  38288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38288
guccccauau gcucacugag                                                   20


<210>  38289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38289
aggggcuugu ggucuagugg                                                   20


<210>  38290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38290
gcuugaccgc ucuccagacg                                                   20


<210>  38291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38291
cucuguggag cagugucuuc                                                   20


<210>  38292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38292
gagcggcugc caugccacug                                                   20


<210>  38293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38293
ucacaggugc uccuggcucu                                                   20


<210>  38294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38294
uagcugcuuc ccgugugucu                                                   20


<210>  38295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38295
cgugugucuc aguuacacac                                                   20


<210>  38296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38296
cgucucauca gugcacacau                                                   20


<210>  38297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38297
gcacugaaag ggauacugcu                                                   20


<210>  38298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38298
gugcugaaaa gcaaccauca                                                   20


<210>  38299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38299
ggaucugguu agggaagaag                                                   20


<210>  38300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38300
cuaaccagau ccugaaacac                                                   20


<210>  38301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38301
ucccuaacca gauccugaaa                                                   20


<210>  38302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38302
uguuaccaca cagggcccca                                                   20


<210>  38303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38303
uggcacuguu gucaaccagg                                                   20


<210>  38304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38304
aacgcuucgu ggcacuguug                                                   20


<210>  38305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38305
acaugcaaau gcuccacaaa                                                   20


<210>  38306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38306
cauuauguuu uugcugcuuu                                                   20


<210>  38307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38307
uuuguuauga uuuuuaaaaa                                                   20


<210>  38308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38308
cgcugcgccg uuucugcaua                                                   20


<210>  38309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38309
gcauauuccu uuauguagcu                                                   20


<210>  38310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38310
uuuauguagc uuucaaacuc                                                   20


<210>  38311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38311
aacuccucuu aggaguucug                                                   20


<210>  38312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38312
ggucccuaca gggcguggga                                                   20


<210>  38313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38313
aacuccucuu aggaguucug                                                   20


<210>  38314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38314
ggucccuaca ggguguggga                                                   20


<210>  38315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38315
ucugucuagc ucguggaggc                                                   20


<210>  38316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38316
uacuccaguu gcuuaggcuc                                                   20


<210>  38317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38317
ccacuuggaa agucccucac                                                   20


<210>  38318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38318
aaguggggaa agucagagcc                                                   20


<210>  38319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38319
caucggcauu uuccccagua                                                   20


<210>  38320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38320
ccaguauuag agccaaggcc                                                   20


<210>  38321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38321
ugauccuggg aggagggacg                                                   20


<210>  38322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38322
uugugaagcc agaguggugg                                                   20


<210>  38323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38323
caaggaaagc cuuuccugau                                                   20


<210>  38324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38324
agacgacuuc uucccacccc                                                   20


<210>  38325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38325
ucccacccca ggacaucaug                                                   20


<210>  38326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38326
caccccagga caucaugaac                                                   20


<210>  38327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38327
ugauguccug gggugggaag                                                   20


<210>  38328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38328
guccaaccag cagccauacc                                                   20


<210>  38329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38329
uggccaccgu gguguauaag                                                   20


<210>  38330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38330
cacuccaucc ccaucccaca                                                   20


<210>  38331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38331
cagcagauuc gccagcagag                                                   20


<210>  38332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38332
ccagcagagc ccagcuccuc                                                   20


<210>  38333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38333
cgucccccca gcccugacac                                                   20


<210>  38334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38334
gacucugcac agcaccgggc                                                   20


<210>  38335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38335
cgcagagggc cccggucgcc                                                   20


<210>  38336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38336
uugucagcgc guccaccagc                                                   20


<210>  38337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38337
cuugucaaca ccgaggcuca                                                   20


<210>  38338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38338
ugauaagguu uugaaaccua                                                   20


<210>  38339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38339
aaaccuuauc augaaacaug                                                   20


<210>  38340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38340
cuggggcuga gggccuguca                                                   20


<210>  38341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38341
guaccccugu cagcauuuua                                                   20


<210>  38342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38342
guggagggcc ugggugaggg                                                   20


<210>  38343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38343
ccugacacug cuucucauua                                                   20


<210>  38344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38344
cauuagcuuu ggucauugug                                                   20


<210>  38345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38345
ccgagagggc gaucgaggca                                                   20


<210>  38346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38346
cacccccaga ugcuggcugc                                                   20


<210>  38347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38347
cuuuccacag cccuucccca                                                   20


<210>  38348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38348
acagcccuuc cccaagacag                                                   20


<210>  38349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38349
ccaagacaga ccacaagagc                                                   20


<210>  38350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38350
gcuggccucc acuagcccug                                                   20


<210>  38351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38351
ugcaacccuu ggcuggcugg                                                   20


<210>  38352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38352
ggggcucugc ucgcucucca                                                   20


<210>  38353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38353
ggagaggaac ucccagguga                                                   20


<210>  38354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38354
ucuccugaaa cagucuacaa                                                   20


<210>  38355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38355
ccucauuugc cggccuuuuu                                                   20


<210>  38356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38356
uuaacuccug caccagccuc                                                   20


<210>  38357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38357
cguccaccug cuccagcuug                                                   20


<210>  38358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38358
gccuggucgc cacagacuuc                                                   20


<210>  38359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38359
acagacacca gauagaggag                                                   20


<210>  38360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38360
agucugugcu ugaggugguu                                                   20


<210>  38361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38361
uggggcugca accaccucaa                                                   20


<210>  38362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38362
uaaacaaguc agcagccggu                                                   20


<210>  38363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38363
aaaggcuccg gccccagcug                                                   20


<210>  38364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38364
gcacaugccg cgggcggcca                                                   20


<210>  38365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38365
gccacauggc agagacacgc                                                   20


<210>  38366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38366
agaaagcagg agcagcugug                                                   20


<210>  38367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38367
ggaaggccuc aggcucagcc                                                   20


<210>  38368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38368
ccugauaguc accugcuggu                                                   20


<210>  38369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38369
ggcccagaug caagagcagc                                                   20


<210>  38370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38370
acugcaggac agcagagggg                                                   20


<210>  38371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38371
caaagccugc ucacggcacc                                                   20


<210>  38372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38372
cccuucucuc uuuucuucuc                                                   20


<210>  38373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38373
cucuuuucuu cucaggauuu                                                   20


<210>  38374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38374
ucucaggauu uaaaauuuaa                                                   20


<210>  38375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38375
caggauuuaa aauuuaauua                                                   20


<210>  38376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38376
augcccgugu aaaguaugug                                                   20


<210>  38377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38377
cauacuuuac acgggcauag                                                   20


<210>  38378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38378
guuguacaug uuccuguuua                                                   20


<210>  38379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38379
uguuuaugca uucacaaggu                                                   20


<210>  38380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38380
caaggugacu gggauguaga                                                   20


<210>  38381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38381
ccacccacca gucagggaca                                                   20


<210>  38382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38382
cagcugagug acagggaggc                                                   20


<210>  38383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38383
uugcuagccc ugggguggcg                                                   20


<210>  38384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38384
gcccccguuc cagcugacau                                                   20


<210>  38385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38385
agcugacauc uugcacggug                                                   20


<210>  38386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38386
auuuuaauga cuuggcuccu                                                   20


<210>  38387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38387
ggauggccgg gcugcugcug                                                   20


<210>  38388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38388
ucagcccuag aggcgagcca                                                   20


<210>  38389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38389
auacccaaaa caucgacggg                                                   20


<210>  38390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38390
uccacuuacc acauucaaua                                                   20


<210>  38391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38391
aacauuuccu ccacuuacca                                                   20


<210>  38392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38392
accugucccu cuccuaugug                                                   20


<210>  38393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38393
gcucccccuc acguaugugg                                                   20


<210>  38394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38394
caccagcucc caacagaggc                                                   20


<210>  38395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38395
accgcuccug cugccccgcc                                                   20


<210>  38396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38396
cuuaagggcc uccucaaaca                                                   20


<210>  38397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38397
guagcuuccc uuaagggccu                                                   20


<210>  38398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38398
uacguguuau aauucaguag                                                   20


<210>  38399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38399
guauugguug ggggcuccug                                                   20


<210>  38400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38400
cauccuagcu uuuuccugga                                                   20


<210>  38401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38401
uggaaagccc gcuagaaggu                                                   20


<210>  38402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38402
aggaaaaagc uaggaugaga                                                   20


<210>  38403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38403
agcgggcuuu ccaggaaaaa                                                   20


<210>  38404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38404
caaaccuucu agcgggcuuu                                                   20


<210>  38405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38405
ccucguuccc aaaccuucua                                                   20


<210>  38406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38406
cagaacuguu ggcugcuccc                                                   20


<210>  38407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38407
gagaacuuuc cccucguucc                                                   20


<210>  38408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38408
uggcuagaug uuuacauuug                                                   20


<210>  38409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38409
uacaaaugua aacaucuagc                                                   20


<210>  38410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38410
caguguuauu ucuuacaaau                                                   20


<210>  38411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38411
cuuggaaugc auaucgcugg                                                   20


<210>  38412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38412
aagggaaugg cucuguuuua                                                   20


<210>  38413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38413
ucuuguuuac gacgugaucu                                                   20


<210>  38414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38414
gagccccuug cuaaggacug                                                   20


<210>  38415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38415
ucuccggagc acacaggcag                                                   20


<210>  38416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38416
cccacgcaua uacauaaagu                                                   20


<210>  38417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38417
uccuggaagu ugacuuuccu                                                   20


<210>  38418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38418
uggaaguuga cuuuccuuag                                                   20


<210>  38419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38419
aggaagaacc gacacgggca                                                   20


<210>  38420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38420
uuagacccgc caggucaagu                                                   20


<210>  38421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38421
uugcccacua ggaucccacu                                                   20


<210>  38422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38422
ccagugggau ccuagugggc                                                   20


<210>  38423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38423
gcagagagcu gauauggaga                                                   20


<210>  38424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38424
ucccuucugc agagagcuga                                                   20


<210>  38425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38425
uaaaaaucug uggcaagcac                                                   20


<210>  38426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38426
ugcugguaau aucgggaaag                                                   20


<210>  38427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38427
cgauauuacc agcaggaaaa                                                   20


<210>  38428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38428
uuaaaaucuu ucccgauauu                                                   20


<210>  38429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38429
acccugguuu cauuaaaauc                                                   20


<210>  38430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38430
gugcauugcc aaacaauucu                                                   20


<210>  38431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38431
uucccaaaau gugccucccu                                                   20


<210>  38432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38432
caaaaugugc cucccuuccg                                                   20


<210>  38433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38433
gcugcgggcc cagcugaguc                                                   20


<210>  38434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38434
agcugccaag ugcucuuugu                                                   20


<210>  38435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38435
gccagcgcau guguccuuuc                                                   20


<210>  38436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38436
aggggaaaau gugaagcuga                                                   20


<210>  38437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38437
ccuugaaagg acacaugcgc                                                   20


<210>  38438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38438
cauuuucccc uugaaaggac                                                   20


<210>  38439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38439
gcuucacauu uuccccuuga                                                   20


<210>  38440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38440
gggugucugg aggggguuca                                                   20


<210>  38441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38441
cagaugcuac auucugggug                                                   20


<210>  38442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38442
uggagggggu cauuucagag                                                   20


<210>  38443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38443
gagcccucgg agccaaugaa                                                   20


<210>  38444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38444
uuggcuccga gggcucugaa                                                   20


<210>  38445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38445
accugccagg cggccacaca                                                   20


<210>  38446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38446
ucccguugcg ggguggagug                                                   20


<210>  38447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38447
gugugucugg uggguggagu                                                   20


<210>  38448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38448
cuugcuaccu gugagcaucc                                                   20


<210>  38449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38449
cagcagacau ccucaucggg                                                   20


<210>  38450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38450
ucccucugcg gggaggaccc                                                   20


<210>  38451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38451
cacuccuaca cgugaccccu                                                   20


<210>  38452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38452
ucucacuccu acacgugacc                                                   20


<210>  38453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38453
uucuucucac uccuacacgu                                                   20


<210>  38454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38454
caggaggccc aggcccggca                                                   20


<210>  38455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38455
gagcagcucc cuccuuccca                                                   20


<210>  38456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38456
guugucaugc ggcauucuga                                                   20


<210>  38457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38457
agguugccuu caguugucau                                                   20


<210>  38458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38458
ggggccgcuc uucccccaug                                                   20


<210>  38459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38459
cccaugugcc ugucacgcuc                                                   20


<210>  38460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38460
uuugacugca ccagagcgug                                                   20


<210>  38461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38461
ccucaguugu uucuaagagc                                                   20


<210>  38462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38462
aagagcagag ucucccgcug                                                   20


<210>  38463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38463
ggucugggug gggcuccggg                                                   20


<210>  38464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38464
gagagcaaag ggaaggacug                                                   20


<210>  38465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38465
cuuugcucuc agaagcauuc                                                   20


<210>  38466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38466
uuuaauuugg auguacaaug                                                   20


<210>  38467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38467
auuuuuuucc uuuaauuugg                                                   20


<210>  38468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38468
ugagaaccua gaccuugcug                                                   20


<210>  38469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38469
caugaagcaa agcaagccuc                                                   20


<210>  38470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38470
uaagacucca gcucagcaag                                                   20


<210>  38471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38471
ccagcagggg cagaaacugu                                                   20


<210>  38472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38472
gccccugcug gagaagcacu                                                   20


<210>  38473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38473
guagccaggg augaggaagu                                                   20


<210>  38474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38474
ucaucccugg cuacagaaaa                                                   20


<210>  38475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38475
gcaagggccu ucccaaacca                                                   20


<210>  38476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38476
caaaccacag uacagguggu                                                   20


<210>  38477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38477
ugcccugcag augggagcug                                                   20


<210>  38478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38478
uggucaagug acaucauaag                                                   20


<210>  38479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38479
gugccauggg ccaaguccug                                                   20


<210>  38480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38480
cacagggccc accacccuuc                                                   20


<210>  38481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38481
accuccuugg ccauugacac                                                   20


<210>  38482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38482
agcuuguuug uccugucuga                                                   20


<210>  38483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38483
gacaggacaa acaagcuaga                                                   20


<210>  38484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38484
uggaguaggc gcugguucag                                                   20


<210>  38485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38485
aagcuccgga cgagccucuc                                                   20


<210>  38486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38486
gagaggcucg uccggagcuu                                                   20


<210>  38487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38487
ugcagguugg uaagacaucu                                                   20


<210>  38488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38488
ucuggugcag gguauuuagu                                                   20


<210>  38489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38489
ggcuaauugg caggggucgu                                                   20


<210>  38490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38490
uucccugcuc ugcugucugu                                                   20


<210>  38491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38491
cugcucugcu gucugugcca                                                   20


<210>  38492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38492
cugagcaggg auagggauca                                                   20


<210>  38493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38493
gagcuaccua aauucugguc                                                   20


<210>  38494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38494
ggucacuuca gagaaaugga                                                   20


<210>  38495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38495
gagaaaugga gcacccccuu                                                   20


<210>  38496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38496
cugaagugac cagaauuuag                                                   20


<210>  38497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38497
cccuggucca gguguggaca                                                   20


<210>  38498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38498
gaaagaagag gggccggggu                                                   20


<210>  38499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38499
gaaauuacca gccaugccag                                                   20


<210>  38500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38500
uucugaaauu accagccaug                                                   20


<210>  38501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38501
cacuggaccc cggccccucu                                                   20


<210>  38502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38502
ccgcugcuuc ccacuggacc                                                   20


<210>  38503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38503
ucuuccucau cggagagcac                                                   20


<210>  38504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38504
ucaucggaga gcacacccug                                                   20


<210>  38505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38505
gugguauuug auuuuggcug                                                   20


<210>  38506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38506
agaucccaac aaagccagua                                                   20


<210>  38507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38507
ccugcguggu gcguggagca                                                   20


<210>  38508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38508
cucaucugac uuacagugcu                                                   20


<210>  38509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38509
guggcggcuc cacccgguac                                                   20


<210>  38510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38510
ucuguccucg guuggcugug                                                   20


<210>  38511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38511
ugggggugug gggugcaccc                                                   20


<210>  38512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38512
cugaggggug caccccacac                                                   20


<210>  38513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38513
ucaggcccca cugcaggcuu                                                   20


<210>  38514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38514
caaaagaggu ccuggugaug                                                   20


<210>  38515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38515
ccacccuaca ccaggccucc                                                   20


<210>  38516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38516
gcccucugcc uccagugaug                                                   20


<210>  38517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38517
ccuugugugc acaggccccu                                                   20


<210>  38518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38518
acccugcccc agcggcggca                                                   20


<210>  38519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38519
ccuccuggcc ccaauugcuc                                                   20


<210>  38520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38520
ccagagcaau uggggccagg                                                   20


<210>  38521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38521
cugccuucac ccaagcccug                                                   20


<210>  38522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38522
cccaagcccu gaacuccuca                                                   20


<210>  38523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38523
gggcuugggu gaaggcagag                                                   20


<210>  38524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38524
aggagcagca guggugagca                                                   20


<210>  38525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38525
guguuuggga gcccugcugc                                                   20


<210>  38526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38526
gcccugccug acaggccagc                                                   20


<210>  38527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38527
ggguggauuu ucugcccugc                                                   20


<210>  38528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38528
aaauaaugag gcugggccca                                                   20


<210>  38529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38529
agccugagcc cagcagggcc                                                   20


<210>  38530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38530
cccucaggug cugcugguug                                                   20


<210>  38531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38531
uguccucaca uuggagguca                                                   20


<210>  38532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38532
cgaggcagag cccucacacu                                                   20


<210>  38533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38533
caggcucagu gcacauggga                                                   20


<210>  38534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38534
caggguaaaa ggcucaacuc                                                   20


<210>  38535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38535
agugggcgca gggaggcagg                                                   20


<210>  38536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38536
gccaggacag uaggccugac                                                   20


<210>  38537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38537
acaaauccac cuuggagcug                                                   20


<210>  38538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38538
gggagggcug ugcccccuua                                                   20


<210>  38539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38539
ucaccuccac aacaggggua                                                   20


<210>  38540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38540
gggugcagcu cuagcgacuc                                                   20


<210>  38541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38541
gcuuaccccu ugugccggga                                                   20


<210>  38542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38542
guagccauga cuccaagggc                                                   20


<210>  38543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38543
gaccgguccc ugaccucacc                                                   20


<210>  38544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38544
gcccuccccg gugaggucag                                                   20


<210>  38545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38545
ugaggagcca gggcuuccua                                                   20


<210>  38546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38546
uagaggaggu aggccuucua                                                   20


<210>  38547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38547
agucacuccu ucaucugcag                                                   20


<210>  38548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38548
ucugcaggca cuccacagag                                                   20


<210>  38549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38549
aucugggccu caggagacau                                                   20


<210>  38550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38550
ucacacaucc cuggggcccu                                                   20


<210>  38551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38551
uauccugacu gcgggcaaga                                                   20


<210>  38552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38552
ccuucccuau gcugggcacc                                                   20


<210>  38553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38553
cuaugcuggg cacccacagu                                                   20


<210>  38554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38554
ccugagagcc ucggucccac                                                   20


<210>  38555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38555
aggcucagcu gcccuucuug                                                   20


<210>  38556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38556
uggggcagcc cacaccugag                                                   20


<210>  38557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38557
ggugccgaug cccuugggcg                                                   20


<210>  38558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38558
ccgggcagaa cccccaggcc                                                   20


<210>  38559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38559
gcccggagaa gugccgccca                                                   20


<210>  38560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38560
gguuccgcug caucuggggc                                                   20


<210>  38561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38561
gcugcaucug gggcucucgg                                                   20


<210>  38562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38562
gcacagcgug cggagacggg                                                   20


<210>  38563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38563
caggagugcc cuguggccuc                                                   20


<210>  38564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38564
cuccuguguc ucaaacagag                                                   20


<210>  38565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38565
aguguccaca gaccuaaggc                                                   20


<210>  38566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38566
cuugcuccag cccccaggcg                                                   20


<210>  38567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38567
ugugagggcc cagccccagg                                                   20


<210>  38568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38568
gaaggcaggg gccuucugag                                                   20


<210>  38569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38569
gaacuggggc ugggcccugg                                                   20


<210>  38570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38570
gagggagcuu aaggguccca                                                   20


<210>  38571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38571
cccaccuuuu gcccccuuuc                                                   20


<210>  38572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38572
ccuugccugu ucccacccga                                                   20


<210>  38573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38573
cacccgaggc ccccucuugg                                                   20


<210>  38574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38574
gugccgcccc ggcucacgca                                                   20


<210>  38575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38575
ugugcuuuca guuaaaaggu                                                   20


<210>  38576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38576
guuaaaaggu uucuguuguu                                                   20


<210>  38577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38577
guuguuguag cuuaugcagu                                                   20


<210>  38578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38578
auagcaacag agcaacugca                                                   20


<210>  38579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38579
cguuuaaaag cuuuuaacua                                                   20


<210>  38580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38580
ugccugucag auguaggccc                                                   20


<210>  38581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38581
agcgagcgug agcggcgccu                                                   20


<210>  38582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38582
ccgccugggg agacacgagg                                                   20


<210>  38583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38583
ucgacgagcu caagcagacc                                                   20


<210>  38584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38584
acgagcucaa gcagaccaag                                                   20


<210>  38585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38585
cguacaccuu ggcguugcgc                                                   20


<210>  38586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38586
agaugaccgg cgagcgcagg                                                   20


<210>  38587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38587
aguacaggug ggcgagcggg                                                   20


<210>  38588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38588
uggagcucug agucgggacg                                                   20


<210>  38589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38589
gcccauaccc ggccagagga                                                   20


<210>  38590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38590
gugggccccg ucucaccccg                                                   20


<210>  38591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38591
auuggggaag uggggaaacu                                                   20


<210>  38592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38592
ccaauggaag gcugcacaca                                                   20


<210>  38593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38593
ccacuucccc aauggaaggc                                                   20


<210>  38594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38594
ugcccuugcu gggccucagu                                                   20


<210>  38595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38595
ggggccuacu gcgucauugg                                                   20


<210>  38596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38596
ccaaugacgc aguaggcccc                                                   20


<210>  38597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38597
cacuugcagu cucaauuucc                                                   20


<210>  38598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38598
agaaaucacc aggugaggug                                                   20


<210>  38599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38599
ggaaauaccc caccgugacc                                                   20


<210>  38600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38600
caccguaagc cccacccaug                                                   20


<210>  38601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38601
ucgcaccgua agccccaccc                                                   20


<210>  38602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38602
ucuucgcacc guaagcccca                                                   20


<210>  38603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38603
ugcccuggca accugcaggg                                                   20


<210>  38604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38604
cugcagguug ccagggcagg                                                   20


<210>  38605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38605
ccccaccaug accccugccc                                                   20


<210>  38606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38606
cacccugcaa gacccucacc                                                   20


<210>  38607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38607
ccgcacaccu augaccuuca                                                   20


<210>  38608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38608
agcucuugcu gccacccucg                                                   20


<210>  38609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38609
cccccugcag cuuccagcuc                                                   20


<210>  38610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38610
aggaugggag uggccucacu                                                   20


<210>  38611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38611
gcugugcugg aggccggcuc                                                   20


<210>  38612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38612
cuucugcugu gcuggaggcc                                                   20


<210>  38613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38613
ccacucccac uagggcuggg                                                   20


<210>  38614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38614
guugcguuga uuugauuuuu                                                   20


<210>  38615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38615
gagccuugaa ggaggggucc                                                   20


<210>  38616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38616
aggcucagaa aaaaucaaau                                                   20


<210>  38617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38617
gagguucggu ggacacaggc                                                   20


<210>  38618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38618
guggacacag gcagcugccc                                                   20


<210>  38619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38619
cguggccucc uaguccugcu                                                   20


<210>  38620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38620
ucaccaggug ccugagcagg                                                   20


<210>  38621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38621
agcaggcucc ccucugacuc                                                   20


<210>  38622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38622
ugagucagag gggagccugc                                                   20


<210>  38623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38623
cgggcaccac cucccuggcu                                                   20


<210>  38624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38624
uuauuuaugc ugaaagccuc                                                   20


<210>  38625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38625
gcauaaauaa ugaauaaccu                                                   20


<210>  38626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38626
gagucccagg ggaggguuuc                                                   20


<210>  38627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38627
gucuccauuc cuggaggcug                                                   20


<210>  38628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38628
uggaggcuga gagaugaggg                                                   20


<210>  38629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38629
ucagccauga cgugcagugc                                                   20


<210>  38630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38630
acaccgcagc cccucagagc                                                   20


<210>  38631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38631
ccgaggggga agcugaggcc                                                   20


<210>  38632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38632
cccucgguga acuaaggcug                                                   20


<210>  38633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38633
ucugcuaagg acuauguggc                                                   20


<210>  38634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38634
uuauacccgc agucucccca                                                   20


<210>  38635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38635
uuuuuuuuuc uuuuucuuuu                                                   20


<210>  38636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38636
uuuucuuuuu uuuuuuuuua                                                   20


<210>  38637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38637
uuuuuuuuuu uuuacaagaa                                                   20


<210>  38638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38638
uguaaaaaaa aaaaaaagaa                                                   20


<210>  38639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38639
gcccaacagc cuuaauauau                                                   20


<210>  38640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38640
ucagcccaac agccuuaaua                                                   20


<210>  38641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38641
guggagcaug guuuguugaa                                                   20


<210>  38642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38642
acaaaccaug cuccacagaa                                                   20


<210>  38643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38643
caguguagga ggcccccaaa                                                   20


<210>  38644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38644
cguuucucca aagagugggc                                                   20


<210>  38645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38645
ccaaagagug ggcuggcuca                                                   20


<210>  38646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38646
cucucugccc uacuugagcc                                                   20


<210>  38647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38647
cagccacgug ccacccuggg                                                   20


<210>  38648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38648
gaauccagcu uauuguuucc                                                   20


<210>  38649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38649
gaaugaggug cccccagcaa                                                   20


<210>  38650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38650
aacggccaau ggccacaccc                                                   20


<210>  38651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38651
ucccuggccu ggccagagcu                                                   20


<210>  38652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38652
cuggccuggc cagagcuguc                                                   20


<210>  38653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38653
cacacugccu gaugccucau                                                   20


<210>  38654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38654
accaagaaug gcaugggagc                                                   20


<210>  38655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38655
ugguugaacc uacagucugg                                                   20


<210>  38656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38656
ccucucugag ccucuauuuu                                                   20


<210>  38657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38657
uucaccucuc ugagccucua                                                   20


<210>  38658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38658
guguccacag cccugaguca                                                   20


<210>  38659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38659
cucccgaaca acacaguuau                                                   20


<210>  38660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38660
ggagagaaug ccucagggag                                                   20


<210>  38661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38661
aaaugaauua uuuaaaaagc                                                   20


<210>  38662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38662
uuuugaaagg uagaguaaua                                                   20


<210>  38663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38663
agacucucug caaugagcaa                                                   20


<210>  38664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38664
auaguuucua gacucucugc                                                   20


<210>  38665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38665
cuugcuuuuc uauaguuucu                                                   20


<210>  38666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38666
uuuuuaacau cugagcccgu                                                   20


<210>  38667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38667
ggaccuacac gggcucagau                                                   20


<210>  38668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38668
uucuaagucc auugucaucu                                                   20


<210>  38669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38669
aaguccauug ucaucuugac                                                   20


<210>  38670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38670
cacccuuggc ucuugugucu                                                   20


<210>  38671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38671
ggaaauuaaa augcaugaca                                                   20


<210>  38672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38672
ugaaacgaga gacacaagag                                                   20


<210>  38673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38673
ggccaagguc cccgaguccu                                                   20


<210>  38674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38674
cguauaacca gugcuccuac                                                   20


<210>  38675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38675
uaggagcacu gguuauacgg                                                   20


<210>  38676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38676
aggaugaucg cuccgacagc                                                   20


<210>  38677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38677
gguagugugu cugcuugucc                                                   20


<210>  38678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38678
ccugcccugg gguaucucag                                                   20


<210>  38679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38679
cuaaauggug ggggcugaga                                                   20


<210>  38680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38680
gugcagcuca aaagugaugg                                                   20


<210>  38681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38681
uugacuucuc uggccucagu                                                   20


<210>  38682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38682
cuggccucag ucucccuccu                                                   20


<210>  38683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38683
cagagggugg cugggagcau                                                   20


<210>  38684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38684
cuccugugau gcucccagcc                                                   20


<210>  38685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38685
ggggucuggg gcuuggucuc                                                   20


<210>  38686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38686
cugggcuccc caggcccacc                                                   20


<210>  38687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38687
agguaaaaua gaaguuggcc                                                   20


<210>  38688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38688
auuuuaccuu gaaagcccac                                                   20


<210>  38689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38689
ugccuccaaa uggccaacuu                                                   20


<210>  38690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38690
uguucuugcc uccaaauggc                                                   20


<210>  38691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38691
ccccugcccu ggucuucaag                                                   20


<210>  38692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38692
agucuuucug acaggaggug                                                   20


<210>  38693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38693
gacaggaggu gucagaaaag                                                   20


<210>  38694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38694
gacaccuccu gucagaaaga                                                   20


<210>  38695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38695
cuacuaaaga uacuuuucug                                                   20


<210>  38696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38696
cauugaagac cugagacaaa                                                   20


<210>  38697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38697
augagaaauc cugagucaag                                                   20


<210>  38698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38698
agcugccagc aaaagcguuu                                                   20


<210>  38699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38699
uucuagcugc cagcaaaagc                                                   20


<210>  38700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38700
cguggacuga gcccaguucu                                                   20


<210>  38701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38701
cagacucagc ugccuggggc                                                   20


<210>  38702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38702
gggaggucug cugagaccac                                                   20


<210>  38703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38703
gccucucuac caaggugugc                                                   20


<210>  38704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38704
aggccgccgg gagauaaggg                                                   20


<210>  38705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38705
uucugggacc ucaguuuccc                                                   20


<210>  38706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38706
gggaccucag uuuccccauc                                                   20


<210>  38707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38707
ccaucugccu aaggccgggu                                                   20


<210>  38708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38708
cuacaggggu ccugaguacu                                                   20


<210>  38709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38709
ucucucccug gggguggucu                                                   20


<210>  38710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38710
cccaccaaac ugggcaggug                                                   20


<210>  38711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38711
gggcugcaga ggggcauauc                                                   20


<210>  38712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38712
agaccgaagg gguguggauu                                                   20


<210>  38713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38713
gucuggaaag ggugggaugu                                                   20


<210>  38714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38714
uucuuuuucu uuuuuuuuuu                                                   20


<210>  38715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38715
uuuucuuuuu uuuuuuuuuu                                                   20


<210>  38716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38716
uuuuuuuuuu uuuugagacg                                                   20


<210>  38717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38717
agcgauucuc cugccucagc                                                   20


<210>  38718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38718
ccugccucag ccucccgagu                                                   20


<210>  38719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38719
ccauguuggc caggcugguc                                                   20


<210>  38720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38720
agaccagccu ggccaacaug                                                   20


<210>  38721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38721
gucaaaggcg guggguucug                                                   20


<210>  38722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38722
ggccccuccu uugcacaugg                                                   20


<210>  38723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38723
augugcaaag gaggggccag                                                   20


<210>  38724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38724
ccauuugccc aguaggauug                                                   20


<210>  38725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38725
aggucggagg agcggccggu                                                   20


<210>  38726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38726
ccggccgcuc cuccgaccug                                                   20


<210>  38727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38727
ucaccggccg cuccuccgac                                                   20


<210>  38728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38728
gcagguggca gcucugcacc                                                   20


<210>  38729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38729
ucugcaggug gcagcucugc                                                   20


<210>  38730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38730
accuggccuc uggcaggaug                                                   20


<210>  38731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38731
gagggguauu uugaggaacc                                                   20


<210>  38732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38732
ucaaaauacc ccucagaagg                                                   20


<210>  38733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38733
ugcuggagac uggagccuca                                                   20


<210>  38734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38734
ucggacacag gccagggccu                                                   20


<210>  38735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38735
cuccgaguaa gaacguccua                                                   20


<210>  38736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38736
uacucggagu gaaccccaga                                                   20


<210>  38737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38737
uucuugccug gaacgcacag                                                   20


<210>  38738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38738
ugccuggaac gcacaguuug                                                   20


<210>  38739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38739
aggcaagaau gaaaaaguau                                                   20


<210>  38740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38740
ggauccauca aucagggcau                                                   20


<210>  38741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38741
uuuucgggau ccaucaauca                                                   20


<210>  38742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38742
aucugcuuuc auuuucggga                                                   20


<210>  38743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38743
ggagagagcu cccccagcuc                                                   20


<210>  38744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38744
cuucaggaga gagcuccccc                                                   20


<210>  38745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38745
ucaggcguca gaggccauuu                                                   20


<210>  38746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38746
aggaggcuuu uauucagcuc                                                   20


<210>  38747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38747
gcucuguuug gagcaucagg                                                   20


<210>  38748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38748
acugccuccu uagcaaugac                                                   20


<210>  38749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38749
caugcacagc ccuguugagu                                                   20


<210>  38750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38750
gggugcugga gauaucaugg                                                   20


<210>  38751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38751
ccgcauggga gcauaagcuc                                                   20


<210>  38752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38752
cuacugaccc augugucuuc                                                   20


<210>  38753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38753
agcacuuauc acaaccugca                                                   20


<210>  38754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38754
cagcuccacg uaugucugcc                                                   20


<210>  38755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38755
cuguguggcc acuguuccca                                                   20


<210>  38756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38756
cacuggccgu ucccugugug                                                   20


<210>  38757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38757
guggccuggc ugcuggccac                                                   20


<210>  38758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38758
ugcuuuucaa gcuuaguggg                                                   20


<210>  38759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38759
agcuuagugg gagucuuuug                                                   20


<210>  38760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38760
accaguuuca aacucuuucu                                                   20


<210>  38761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38761
aacucuuucu agaagcucca                                                   20


<210>  38762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38762
agaagcucca gcuuucccaa                                                   20


<210>  38763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38763
agaaagaguu ugaaacuggu                                                   20


<210>  38764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38764
caaagcugaa uucucuauga                                                   20


<210>  38765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38765
gcuuugggaa agcuggagcu                                                   20


<210>  38766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38766
cuaugagccu ccuuggccgg                                                   20


<210>  38767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38767
aggaggugac ucaaacacac                                                   20


<210>  38768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38768
auuugggcag caacuugccu                                                   20


<210>  38769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38769
ccugcugacc caccugccaa                                                   20


<210>  38770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38770
gaaaaaucuc ccucuggcug                                                   20


<210>  38771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38771
gaacccugag ucaaaccaug                                                   20


<210>  38772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38772
cacaggcagg ccgagggcac                                                   20


<210>  38773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38773
guggagccca aaggggagcu                                                   20


<210>  38774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38774
cuucacucug aggguccugg                                                   20


<210>  38775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38775
cucugagggu ccuggagcuc                                                   20


<210>  38776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38776
agcugccaga ugacgccgcu                                                   20


<210>  38777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38777
caaccacagg gucagcggcg                                                   20


<210>  38778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38778
cggcaggugc uauggcagcc                                                   20


<210>  38779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38779
gcuucucggc aggugcuaug                                                   20


<210>  38780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38780
uucugcuucu cggcaggugc                                                   20


<210>  38781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38781
agcuccggga cccacccgcc                                                   20


<210>  38782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38782
uggguggugu cuugccuacg                                                   20


<210>  38783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38783
cagcaucuag gguggcacag                                                   20


<210>  38784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38784
ccagccuccu aacagggagc                                                   20


<210>  38785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38785
cucucgaggg cuugugacug                                                   20


<210>  38786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38786
ugccagggcc gcgggcaccc                                                   20


<210>  38787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38787
aaaugaugua gcaacuucuu                                                   20


<210>  38788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38788
ucacccugaa acugcuguag                                                   20


<210>  38789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38789
cccugaaacu gcuguagagu                                                   20


<210>  38790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38790
gggugaagaa guugcuacau                                                   20


<210>  38791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38791
guaacugcca ggcauccggg                                                   20


<210>  38792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38792
aacccaagca cagcagcgac                                                   20


<210>  38793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38793
ucucgcccuc ucuaaucaga                                                   20


<210>  38794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38794
cgcccucucu aaucagaguc                                                   20


<210>  38795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38795
ugcccuucca ucaccuuaga                                                   20


<210>  38796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38796
aucaccuuag agaaggggca                                                   20


<210>  38797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38797
cuaaggugau ggaagggcau                                                   20


<210>  38798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38798
ccaggcugga gcagcaucgc                                                   20


<210>  38799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38799
gcugacauga ggcgaugcug                                                   20


<210>  38800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38800
acagcugagu ucugcugaca                                                   20


<210>  38801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38801
ucagcagcau guccuuaaca                                                   20


<210>  38802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38802
gauuucuucc uuaguuguug                                                   20


<210>  38803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38803
uccuuaguug uugguccauu                                                   20


<210>  38804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38804
uuaguuguug guccauuaag                                                   20


<210>  38805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38805
ccuuaaugga ccaacaacua                                                   20


<210>  38806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38806
gcaaagcagc auguuaacau                                                   20


<210>  38807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38807
auguuaacau gcugcuuugc                                                   20


<210>  38808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38808
aguuuucaau guuaacaugc                                                   20


<210>  38809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38809
ccuguaguau uucauguugu                                                   20


<210>  38810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38810
uguuguuuug acguuuuuag                                                   20


<210>  38811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38811
cgccuguaau cccagcacuu                                                   20


<210>  38812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38812
agaccagccu gaccaacaug                                                   20


<210>  38813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38813
ccauguuggu caggcugguc                                                   20


<210>  38814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38814
ccugccucag ccucccaagu                                                   20


<210>  38815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38815
agcgauucuc cugccucagc                                                   20


<210>  38816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38816
cugucaccca ggcuggagug                                                   20


<210>  38817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38817
uauccugcuu auuuuauuua                                                   20


<210>  38818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38818
uuucuuaucc ugcuuauuuu                                                   20


<210>  38819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38819
ucauuucuua uccugcuuau                                                   20


<210>  38820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38820
gauuucauuu uuguauaccc                                                   20


<210>  38821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38821
uuuuuguaua cccagaaagc                                                   20


<210>  38822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38822
ggguauacaa aaaugaaauc                                                   20


<210>  38823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38823
acaaguuuaa gcugguuuaa                                                   20


<210>  38824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38824
uccucauuuu caacaaguuu                                                   20


<210>  38825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38825
ucauccucau uuucaacaag                                                   20


<210>  38826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38826
gaguuggaau gaauuuaacc                                                   20


<210>  38827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38827
aacucugaau gggauauuuc                                                   20


<210>  38828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38828
uuccaacucu gaaugggaua                                                   20


<210>  38829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38829
ggguuaaauu cauuccaacu                                                   20


<210>  38830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38830
uucuggguua aauucauucc                                                   20


<210>  38831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38831
guagaggucc uguuccuucu                                                   20


<210>  38832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38832
cuucaguaga gguccuguuc                                                   20


<210>  38833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38833
guaagacugc auaguucucu                                                   20


<210>  38834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38834
ccagcgcuca gguauuauuu                                                   20


<210>  38835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38835
cacacuccug aaagcuccaa                                                   20


<210>  38836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38836
ggagugugcg aaguuucucc                                                   20


<210>  38837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38837
aaacauaguc ucaauaauau                                                   20


<210>  38838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38838
ugguuuugac auggacgcga                                                   20


<210>  38839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38839
uaugaaaaaa gaacggggcc                                                   20


<210>  38840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38840
uaugaauuua aacaucaucg                                                   20


<210>  38841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38841
uuuuucauau gaauuuaaac                                                   20


<210>  38842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38842
cacgcugacu ggccuuggac                                                   20


<210>  38843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38843
aacuccccga cuccgaggga                                                   20


<210>  38844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38844
uccuggccuc cagcagccac                                                   20


<210>  38845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38845
cgacguucgu ccuggccucc                                                   20


<210>  38846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38846
aggagcaauu uggugucccg                                                   20


<210>  38847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38847
gcuuuaggac gggacaccaa                                                   20


<210>  38848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38848
ucagcuuuag gacgggacac                                                   20


<210>  38849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38849
ucuggucagu gccacuccua                                                   20


<210>  38850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38850
ccguguuagc caggaugauc                                                   20


<210>  38851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38851
ccuggcucag ccucccaagu                                                   20


<210>  38852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38852
cgccauucuc cuggcucagc                                                   20


<210>  38853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38853
uuaaaagugc caaagaacuu                                                   20


<210>  38854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38854
uuggcacuuu uaaugaauuu                                                   20


<210>  38855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38855
aaugaccaau auuaauacac                                                   20


<210>  38856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38856
aauguguauu aauauugguc                                                   20


<210>  38857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38857
aauaagauau ucuaaugugu                                                   20


<210>  38858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38858
aaaggucuca gguuuaauuu                                                   20


<210>  38859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38859
uuucaaaaua gcaauaaacc                                                   20


<210>  38860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38860
aaauagcaau aaacccauga                                                   20


<210>  38861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38861
uacaauuguu auuuauguua                                                   20


<210>  38862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38862
aaaacaaaaa guuuucggga                                                   20


<210>  38863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38863
ggagaagugu ggcauaguuu                                                   20


<210>  38864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38864
cccgaaaacu uuuuguuuug                                                   20


<210>  38865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38865
cuuaagccag agauuuacga                                                   20


<210>  38866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38866
caaccaaaac acccccaaag                                                   20


<210>  38867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38867
cuccuauacu ucacaaccaa                                                   20


<210>  38868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38868
ccauucacuc cuauacuuca                                                   20


<210>  38869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38869
uacccagaug uguauuugaa                                                   20


<210>  38870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38870
aauacacauc uggguaagaa                                                   20


<210>  38871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38871
uuucaaauac acaucugggu                                                   20


<210>  38872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38872
uuuucuuuuc aaauacacau                                                   20


<210>  38873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38873
uccgugaucc uauuccaaca                                                   20


<210>  38874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38874
gugauccuau uccaacacug                                                   20


<210>  38875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38875
aacacuggac aggugguggu                                                   20


<210>  38876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38876
gcucacugca agcuccgccu                                                   20


<210>  38877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38877
cugcaagcuc ugccucccgg                                                   20


<210>  38878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38878
cgccauucuc cugccucagc                                                   20


<210>  38879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38879
ccugccucag ccuccugagu                                                   20


<210>  38880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38880
cuguguuagc caggaugguc                                                   20


<210>  38881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38881
agcacuuugg gaggccgagg                                                   20


<210>  38882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38882
acacacaacc ggccaguaaa                                                   20


<210>  38883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38883
uugauagggu aucagauucc                                                   20


<210>  38884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38884
acuucauuuc aggagaaucc                                                   20


<210>  38885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38885
uuucaggaga auccauuggu                                                   20


<210>  38886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38886
ggagaaucca uugguccguc                                                   20


<210>  38887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38887
ccugaaauga aguagaaguu                                                   20


<210>  38888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38888
aggacucugu ccaucaugcc                                                   20


<210>  38889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38889
cuaaguuaug cggauauucc                                                   20


<210>  38890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38890
aaaugcugac acaguuccuu                                                   20


<210>  38891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38891
uuaaucagua uuuuaaaauc                                                   20


<210>  38892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38892
aagauuggug auaucgccaa                                                   20


<210>  38893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38893
guuggaaagg uggugaacuc                                                   20


<210>  38894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38894
aacugaaaga cuuuucuaag                                                   20


<210>  38895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38895
ccaccuuucc aacugaaaga                                                   20


<210>  38896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38896
gaauucugau uuuugcauga                                                   20


<210>  38897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38897
gaaagacacc accaugaguu                                                   20


<210>  38898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38898
gauuuuugca ugaaagcuug                                                   20


<210>  38899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38899
ugcaaaaauc agaauucuga                                                   20


<210>  38900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38900
agcuuucaug caaaaaucag                                                   20


<210>  38901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38901
uugaaugaga caggcucacu                                                   20


<210>  38902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38902
aagaaaauag cugacagcau                                                   20


<210>  38903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38903
uuuuccaaaa aaaaaaaguc                                                   20


<210>  38904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38904
aaaaaaaaaa agucugccag                                                   20


<210>  38905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38905
gccuugggug uccuggcaga                                                   20


<210>  38906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38906
agauccagac ggcagcucag                                                   20


<210>  38907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38907
ucagcgugga cguggggcag                                                   20


<210>  38908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38908
aguugcucgg gcaggacguu                                                   20


<210>  38909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38909
acguccugcc cgagcaacug                                                   20


<210>  38910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38910
cuccaucacg gacauuugga                                                   20


<210>  38911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38911
aaauguccgu gauggaguga                                                   20


<210>  38912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38912
cacugcagcu gugcggugcg                                                   20


<210>  38913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38913
caccgcacag cugcagugug                                                   20


<210>  38914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38914
ugcucagguc uugccacauc                                                   20


<210>  38915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38915
cggagcugac augcgcacug                                                   20


<210>  38916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38916
cggggucuuc acggagcuga                                                   20


<210>  38917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38917
ucauagucug augaucacgg                                                   20


<210>  38918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38918
caggucucgg ccuguggguc                                                   20


<210>  38919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38919
ggcagugguu cucaggucuc                                                   20


<210>  38920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38920
cacacgcugu cugugaugac                                                   20


<210>  38921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38921
accugacccu auccccagug                                                   20


<210>  38922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38922
aguugagggu ggggcuagac                                                   20


<210>  38923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38923
aacauacuag acacuuacgu                                                   20


<210>  38924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38924
agggaaauaa ggcuguaggg                                                   20


<210>  38925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38925
cuggaaagca ccucucuucu                                                   20


<210>  38926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38926
cucaccccac ggcuccaauc                                                   20


<210>  38927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38927
aaaaauguca ugugagcgga                                                   20


<210>  38928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38928
gcugggacaa gagagucccg                                                   20


<210>  38929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38929
auccuccccu aggccaggau                                                   20


<210>  38930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38930
ccaugcccgg gcaacagcca                                                   20


<210>  38931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38931
gguuuuuccc caugcccggg                                                   20


<210>  38932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38932
gaguccugga gauggccacg                                                   20


<210>  38933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38933
cccacacgcu ccaccuugcg                                                   20


<210>  38934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38934
gcccaaguuc aucucagcug                                                   20


<210>  38935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38935
ucucagcugg guccggaggg                                                   20


<210>  38936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38936
agggguaggg ugcccucucc                                                   20


<210>  38937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38937
acuguaagau gcucguguuc                                                   20


<210>  38938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38938
aacuggcuuu uucuacugua                                                   20


<210>  38939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38939
aaaauagaag ccaagaacug                                                   20


<210>  38940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38940
auuuuagaag guaaggcggu                                                   20


<210>  38941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38941
uggcuucuau uuuagaaggu                                                   20


<210>  38942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38942
cggcuuggcu ggucaugucc                                                   20


<210>  38943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38943
caugugcgca guguucacgg                                                   20


<210>  38944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38944
ugguacaucc guggcuugug                                                   20


<210>  38945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38945
cugagcugag gggagccugu                                                   20


<210>  38946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38946
cugcccucug uuuaucuccg                                                   20


<210>  38947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38947
cugcuuuccg ucaaggcuaa                                                   20


<210>  38948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38948
gucaaggcua aucugcucuc                                                   20


<210>  38949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38949
uagggagugc aaggucgggc                                                   20


<210>  38950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38950
ccaaacguca cagccuuucu                                                   20


<210>  38951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38951
cugauccuuu uuccagguag                                                   20


<210>  38952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38952
agguagccca caggcuacag                                                   20


<210>  38953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38953
cucgcccugg gcacacccuc                                                   20


<210>  38954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38954
uaggagguca cggaggaagc                                                   20


<210>  38955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38955
uccgugaccu ccuaggaaga                                                   20


<210>  38956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38956
aaagcugcag ggcuuccucc                                                   20


<210>  38957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38957
cagugcuggu guagcuuagu                                                   20


<210>  38958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38958
ccuuuggaaa cgguuuuuag                                                   20


<210>  38959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38959
aaaggagaac uucccagugc                                                   20


<210>  38960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38960
gcucaugcca gccugccuga                                                   20


<210>  38961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38961
uagcggcaga ucaggcaggc                                                   20


<210>  38962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38962
cgcacaagua ccugcugcuc                                                   20


<210>  38963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38963
gagcagcagg uacuugugcg                                                   20


<210>  38964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38964
gcaauauacc ugcguuaaaa                                                   20


<210>  38965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38965
uguuaaugcu ggcagaaugc                                                   20


<210>  38966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38966
gccagcauua acaagaagca                                                   20


<210>  38967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38967
agaggaggag ggcauucugc                                                   20


<210>  38968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38968
cccguucaag aggaggaggg                                                   20


<210>  38969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38969
agugugugga ggcacaguca                                                   20


<210>  38970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38970
aggcuuucuc ugcaauaaac                                                   20


<210>  38971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38971
cugcaauaaa ccguggugca                                                   20


<210>  38972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38972
aaacucacua guguacacaa                                                   20


<210>  38973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38973
ccuagaguua uaaguguuuu                                                   20


<210>  38974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38974
uuuccccuag aguuauaagu                                                   20


<210>  38975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38975
uguacaacuu uucguuuccc                                                   20


<210>  38976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38976
cuuuccugua caacuuuucg                                                   20


<210>  38977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38977
acacagauau cccguuguua                                                   20


<210>  38978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38978
acaaacggug cuguaacaac                                                   20


<210>  38979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38979
ugaagaugga uggccugugg                                                   20


<210>  38980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38980
agaaagaguc caaagccacu                                                   20


<210>  38981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38981
cuuuuuuagg aucugaaauu                                                   20


<210>  38982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38982
uguuaugaac caaucaaagc                                                   20


<210>  38983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38983
uaacaugaau ggggacauuu                                                   20


<210>  38984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38984
aaaaaaucgg guuuugguau                                                   20


<210>  38985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38985
gacgcuacau ucuggagugu                                                   20


<210>  38986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38986
ggaguguucu acugacacca                                                   20


<210>  38987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38987
acugacacca ucugccagga                                                   20


<210>  38988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38988
aagaaucccc accugugugc                                                   20


<210>  38989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38989
uggaagugug gguccuggca                                                   20


<210>  38990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38990
agagcagaca gaugggguca                                                   20


<210>  38991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38991
ccugaccauc aguggccucu                                                   20


<210>  38992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38992
ugccgggccc ugcugaccag                                                   20


<210>  38993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38993
gguaucucac uugucucaug                                                   20


<210>  38994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38994
ucagguaucu cacuugucuc                                                   20


<210>  38995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38995
ugccaaaucu ggcaaacugc                                                   20


<210>  38996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38996
uuuccauauu gcuucuugcg                                                   20


<210>  38997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38997
auauugcuuc uugcgcaaac                                                   20


<210>  38998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38998
ugcgcaaaca gacgaggugg                                                   20


<210>  38999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  38999
agggcccuga ggcaguccug                                                   20


<210>  39000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39000
gugggagaca gaaauaaaau                                                   20


<210>  39001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39001
gucucccaca gaagcagcca                                                   20


<210>  39002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39002
caaccaugcc agcguuauuu                                                   20


<210>  39003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39003
acguuugaag ccaaaugcaa                                                   20


<210>  39004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39004
aacguggaaa uaacgcuggc                                                   20


<210>  39005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39005
cucucaaaaa uugcauuugg                                                   20


<210>  39006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39006
acacucccuc cccuuuuggg                                                   20


<210>  39007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39007
acuccuacag cauggcauug                                                   20


<210>  39008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39008
gcagccucac gagccaaugc                                                   20


<210>  39009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39009
accugcugca ggcuggaagg                                                   20


<210>  39010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39010
agccugcagc agguggaacc                                                   20


<210>  39011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39011
caccacauca gccuuccagc                                                   20


<210>  39012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39012
ccucaggcug cccucccggc                                                   20


<210>  39013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39013
ugccuuucuc cucaggcugc                                                   20


<210>  39014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39014
gaauguggug ccacugucag                                                   20


<210>  39015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39015
gaagguuuuu ccugccuuuc                                                   20


<210>  39016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39016
ccaagaagga gauggccuug                                                   20


<210>  39017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39017
uggggaacuu ugcugacagu                                                   20


<210>  39018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39018
uagcacccca cgggcagaga                                                   20


<210>  39019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39019
ccaggcucca cggggcccca                                                   20


<210>  39020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39020
agccagcgua gaucaggucu                                                   20


<210>  39021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39021
ccuccuugag ggccaaccca                                                   20


<210>  39022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39022
cuuacucacc cgugcugcca                                                   20


<210>  39023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39023
uccugacuug gagacccugu                                                   20


<210>  39024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39024
ggggcucugu ccucugcgag                                                   20


<210>  39025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39025
aagccgcucc ccaggggugc                                                   20


<210>  39026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39026
caggcgcacc ugggagcugu                                                   20


<210>  39027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39027
caccugcgaa aggggagcgg                                                   20


<210>  39028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39028
caggugagaa caggguuccc                                                   20


<210>  39029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39029
ccuccccgcu ccccuuucgc                                                   20


<210>  39030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39030
uccugcuccu ccuccugcag                                                   20


<210>  39031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39031
gccagcuucu agaaccuucc                                                   20


<210>  39032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39032
agaaccuucc ccacagugcu                                                   20


<210>  39033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39033
agaagcuggc agaagcccuc                                                   20


<210>  39034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39034
ccacagugcu gcacugacca                                                   20


<210>  39035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39035
uuaguucccc gcaggguuag                                                   20


<210>  39036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39036
ccgcaggguu agacuccuga                                                   20


<210>  39037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39037
cuuguuuaau ccucagcuca                                                   20


<210>  39038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39038
cgcucggaau uuggauucaa                                                   20


<210>  39039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39039
gagcgugaau gggcucucca                                                   20


<210>  39040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39040
accacggggc ugacccccca                                                   20


<210>  39041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39041
aaaacgccuu ugucuuuucc                                                   20


<210>  39042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39042
uguucaaaga acuuucaaga                                                   20


<210>  39043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39043
aagaacuuuc aagagacuuu                                                   20


<210>  39044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39044
uugaacagga aaagacaaag                                                   20


<210>  39045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39045
agagacuuuc caaguuuugu                                                   20


<210>  39046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39046
aaguuuuguu cgggaacagu                                                   20


<210>  39047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39047
ggaacagugu ggcuccccag                                                   20


<210>  39048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39048
cgaacaaaac uuggaaaguc                                                   20


<210>  39049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39049
ugauaauuag aaauaucaac                                                   20


<210>  39050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39050
aauuaucaug aaauuaaaau                                                   20


<210>  39051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39051
aaacuaaugg aauuuuaaug                                                   20


<210>  39052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39052
aaggcugagc ggcaguugau                                                   20


<210>  39053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39053
auuaguuucg aaggcugagc                                                   20


<210>  39054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39054
uagcuguaac cuaagcagcu                                                   20


<210>  39055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39055
cccagggccu gccucccgca                                                   20


<210>  39056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39056
gcagcugccu guaagggaga                                                   20


<210>  39057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39057
cccuuacagg cagcugcuga                                                   20


<210>  39058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39058
auccccaaaa aagccugcug                                                   20


<210>  39059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39059
gcaggcuuuu uuggggauag                                                   20


<210>  39060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39060
aucucaauac aaauuucagc                                                   20


<210>  39061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39061
auuccaucuc aauacaaauu                                                   20


<210>  39062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39062
uagucccacu ugauaagaac                                                   20


<210>  39063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39063
cacacagaua agaagcuugu                                                   20


<210>  39064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39064
uaucucuaug ucuuuuauuu                                                   20


<210>  39065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39065
cuuucuugcc uuauuuucug                                                   20


<210>  39066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39066
ugccuuauuu ucuggcuaug                                                   20


<210>  39067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39067
ggcuaugagc uccaguacaa                                                   20


<210>  39068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39068
acauuguacu ggagcucaua                                                   20


<210>  39069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39069
ugagggucau ugggcuguaa                                                   20


<210>  39070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39070
uuuucucuug auguccuugu                                                   20


<210>  39071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39071
cuugaugucc uugucagguu                                                   20


<210>  39072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39072
uacaguaagu gcaagagugu                                                   20


<210>  39073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39073
aucuuucucu uuuuucugaa                                                   20


<210>  39074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39074
cuuuuuucug aaaaaaauug                                                   20


<210>  39075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39075
gaaaaaaauu guguaaggau                                                   20


<210>  39076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39076
gaaaaaagag aaagauggaa                                                   20


<210>  39077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39077
uccuuaaaua uuugaucugu                                                   20


<210>  39078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39078
uuaaauauuu gaucuguucc                                                   20


<210>  39079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39079
gugauuucca cucuuauuuu                                                   20


<210>  39080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39080
acucuuauuu uugucauucc                                                   20


<210>  39081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39081
cuuccuucua uuuacuuuag                                                   20


<210>  39082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39082
uucuauuuac uuuagguuua                                                   20


<210>  39083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39083
auuuacuuua gguuuaauuu                                                   20


<210>  39084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39084
agcuucuuaa uguggaagcu                                                   20


<210>  39085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39085
uaauguggaa gcucagauca                                                   20


<210>  39086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39086
acauuaagaa gcuagaaaau                                                   20


<210>  39087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39087
aacuaguuuu uaaauauaaa                                                   20


<210>  39088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39088
uuacuauuca guuaaaaaua                                                   20


<210>  39089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39089
guuaaaaaua auuuucuagu                                                   20


<210>  39090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39090
aguuuucuuu gugauaucuu                                                   20


<210>  39091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39091
uugugauauc uuguuugacc                                                   20


<210>  39092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39092
uucuugguaa auguaccaug                                                   20


<210>  39093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39093
ugguaaaugu accaugugcu                                                   20


<210>  39094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39094
agagcacaug guacauuuac                                                   20


<210>  39095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39095
auauguguua auuagguuag                                                   20


<210>  39096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39096
uuuuuuuuuu uuuuuuuuga                                                   20


<210>  39097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39097
uacugauuau uuugucuggu                                                   20


<210>  39098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39098
caacaauuua uaauagaaua                                                   20


<210>  39099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39099
auuauaaauu guugggaaaa                                                   20


<210>  39100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39100
gauuauuuuu cuuuuuuuag                                                   20


<210>  39101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39101
uuuuuuaguu cuuacaauuu                                                   20


<210>  39102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39102
uacaauuuuu gccucaaaug                                                   20


<210>  39103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39103
aacauuugag gcaaaaauug                                                   20


<210>  39104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39104
uaugguauuu uuccauggua                                                   20


<210>  39105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39105
augguauuuc uuuuuuuuuu                                                   20


<210>  39106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39106
uuuuuuuuuu uuguuaauuc                                                   20


<210>  39107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39107
uuuacuuuua accuaaacuu                                                   20


<210>  39108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39108
uuaauuuacc ucaaucuacu                                                   20


<210>  39109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39109
aaguagauug agguaaauua                                                   20


<210>  39110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39110
acuuauaauu ccauuucccu                                                   20


<210>  39111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39111
ugcagcuuuu guuuaucuga                                                   20


<210>  39112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39112
gauaaacaaa agcugcagga                                                   20


<210>  39113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39113
uuuuuuaagg auguguucac                                                   20


<210>  39114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39114
guuugagaaa auuuuggcca                                                   20


<210>  39115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39115
caaacugaau uuaaaaaaau                                                   20


<210>  39116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39116
uuagauucuc cccauuuuac                                                   20


<210>  39117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39117
ccccauuuua ccuguacucu                                                   20


<210>  39118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39118
gugcacugca aaaaaaaaaa                                                   20


<210>  39119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39119
gauaccauga uagugucauu                                                   20


<210>  39120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39120
uaauagcacc agugucuacu                                                   20


<210>  39121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39121
ucauauuucu auuugugauu                                                   20


<210>  39122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39122
uauuucuauu ugugauuguu                                                   20


<210>  39123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39123
auuugugauu guuuccagag                                                   20


<210>  39124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39124
agagcuucuc acacaugagc                                                   20


<210>  39125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39125
cacacaugag cagagcaguc                                                   20


<210>  39126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39126
cuuacccauu gugauagcac                                                   20


<210>  39127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39127
ucuucccuua cccauuguga                                                   20


<210>  39128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39128
aggcuuccuc uucccuuacc                                                   20


<210>  39129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39129
gccauguaca gcacagaguu                                                   20


<210>  39130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39130
aaagcacauc cucacucuug                                                   20


<210>  39131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39131
gcaucuuccc aaagauggga                                                   20


<210>  39132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39132
caaagauggg acaucuugac                                                   20


<210>  39133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39133
gagggugauu auaaggucaa                                                   20


<210>  39134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39134
uuugugguuc ugagggugau                                                   20


<210>  39135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39135
aucuaauugc uuuaacagca                                                   20


<210>  39136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39136
agauguauua gaagaguuaa                                                   20


<210>  39137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39137
aauacaucuu gaauacugua                                                   20


<210>  39138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39138
uuuuuuuggg gguaagccuu                                                   20


<210>  39139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39139
uuccuuuuuu uggggguaag                                                   20


<210>  39140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39140
uuucuuuccu uuuuuugggg                                                   20


<210>  39141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39141
aauuaaaaaa uauaucuaaa                                                   20


<210>  39142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39142
aguaaaaucu aaagaaauca                                                   20


<210>  39143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39143
uuagauuuua cuagaaugcu                                                   20


<210>  39144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39144
gauuucuuua gauuuuacua                                                   20


<210>  39145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39145
uuguucugau uucuuuagau                                                   20


<210>  39146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39146
uuucuuuguu cugauuucuu                                                   20


<210>  39147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39147
auacagauua uuuucugcca                                                   20


<210>  39148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39148
gccauuuuag auuaaggaau                                                   20


<210>  39149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39149
uuaaucuaaa auggcagaaa                                                   20


<210>  39150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39150
auugagauua uuccuuaauc                                                   20


<210>  39151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39151
caucucucuu caauugagau                                                   20


<210>  39152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39152
gguacuuuaa aaauaauauc                                                   20


<210>  39153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39153
uucaaauuug ccagugcuga                                                   20


<210>  39154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39154
aaagcccuuc uuucaaauuu                                                   20


<210>  39155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39155
uacaguauuu cuaaagcccu                                                   20


<210>  39156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39156
ccaucucuua aagcaacacc                                                   20


<210>  39157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39157
ucacaaaaau cacugugaug                                                   20


<210>  39158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39158
uaaauuucau cacaaaaauc                                                   20


<210>  39159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39159
aagaccagcc uggccaacau                                                   20


<210>  39160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39160
ccauguuggc caggcugguc                                                   20


<210>  39161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39161
acuaaaaaua caaaaacuag                                                   20


<210>  39162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39162
guucacucug uuguuccugu                                                   20


<210>  39163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39163
cuggacucaa aucccaaacu                                                   20


<210>  39164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39164
cuuagaagaa aaucaacacu                                                   20


<210>  39165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39165
aagagaaacg uauuuucacu                                                   20


<210>  39166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39166
ucuaagagaa acguauuuuc                                                   20


<210>  39167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39167
cagauaaaga uaauagaauc                                                   20


<210>  39168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39168
aagccuaugc agugaaauuu                                                   20


<210>  39169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39169
gccauaucca auccacuucu                                                   20


<210>  39170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39170
uuucagccau auccaaucca                                                   20


<210>  39171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39171
cugauuuucu uuucagccau                                                   20


<210>  39172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39172
aauucacuga uuuucuuuuc                                                   20


<210>  39173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39173
auugcuguau cuucaaauuc                                                   20


<210>  39174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39174
gacugggcca uuucuauugc                                                   20


<210>  39175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39175
ugcugcugca aucauuuuua                                                   20


<210>  39176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39176
accauuuuuu cuaccucauu                                                   20


<210>  39177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39177
ucaaccauuu uuucuaccuc                                                   20


<210>  39178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39178
aaaauguggu gaaaaacaua                                                   20


<210>  39179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39179
ccacauuuug gaaaucuguc                                                   20


<210>  39180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39180
uggauguuua guuuauguuu                                                   20


<210>  39181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39181
aauaauccug ugugggguuu                                                   20


<210>  39182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39182
gggugcgauu uucuaauaau                                                   20


<210>  39183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39183
cuuucuguuu ggauuucggc                                                   20


<210>  39184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39184
agauuuuucu cuuucuguuu                                                   20


<210>  39185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39185
ggcuauuuuc aagauuuuuc                                                   20


<210>  39186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39186
uguaagguca uuguuucugg                                                   20


<210>  39187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39187
uuucauguaa ggucauuguu                                                   20


<210>  39188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39188
ucagaaauaa uaguggucag                                                   20


<210>  39189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39189
gaugaaaagu cagccaaaau                                                   20


<210>  39190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39190
uucccugagc cucggcggcc                                                   20


<210>  39191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39191
cugagccucg gcggcccaua                                                   20


<210>  39192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39192
gccagcccag cagauugcuc                                                   20


<210>  39193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39193
cauuggccag ggugagcugg                                                   20


<210>  39194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39194
gcccuccccu ccagggcauc                                                   20


<210>  39195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39195
cccccacacc cgcccuucag                                                   20


<210>  39196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39196
uaaugucgcc cagcggggcg                                                   20


<210>  39197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39197
gugagggccg gcacgguggu                                                   20


<210>  39198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39198
cagacucaag ccauccuccu                                                   20


<210>  39199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39199
ucgggccgcc agggccaggg                                                   20


<210>  39200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39200
guguaggaau aauauggucu                                                   20


<210>  39201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39201
uacacagaac uuccucgggc                                                   20


<210>  39202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39202
gguuaaaaac auuaugcuuc                                                   20


<210>  39203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39203
uuuaauuuau uucaucugcu                                                   20


<210>  39204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39204
ucugcucacu gauggugaau                                                   20


<210>  39205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39205
ccaucaguga gcagaugaaa                                                   20


<210>  39206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39206
acaacacggg cacaggaggc                                                   20


<210>  39207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39207
cuguguugcc caggcugguc                                                   20


<210>  39208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39208
aaagagcugg gauuacaggc                                                   20


<210>  39209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39209
uuuguuaauu aaaaauauau                                                   20


<210>  39210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39210
uucuggcuug gcgcugcucu                                                   20


<210>  39211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39211
ggcuuggcgc ugcucuggaa                                                   20


<210>  39212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39212
agagcagcgc caagccagaa                                                   20


<210>  39213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39213
accaucugcg cauaggcagg                                                   20


<210>  39214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39214
cucugucacc uaggcuggag                                                   20


<210>  39215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39215
cucccgccgc guuuuucccu                                                   20


<210>  39216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39216
ccucauucuc ucccgccgcg                                                   20


<210>  39217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39217
ugccuucccc ucauucucuc                                                   20


<210>  39218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39218
uuccugccuu ccccucauuc                                                   20


<210>  39219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39219
ccggcgcugg gucucccugc                                                   20


<210>  39220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39220
uuccccggcg cugggucucc                                                   20


<210>  39221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39221
gcccgcgcca ccgcccgcgc                                                   20


<210>  39222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39222
cucgucggac uccacgagcg                                                   20


<210>  39223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39223
gcccuaacaa agcggccgcu                                                   20


<210>  39224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39224
gagacccgaa cuccagacgc                                                   20


<210>  39225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39225
ggucucggaa ggcagcuucu                                                   20


<210>  39226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39226
cagcaaguga ccaagcaggu                                                   20


<210>  39227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39227
cugugccuga guuuccucau                                                   20


<210>  39228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39228
ucauuggacc ugucuuugga                                                   20


<210>  39229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39229
uaaaacugca aguccagccu                                                   20


<210>  39230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39230
uccgcccuug ucuuugucaa                                                   20


<210>  39231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39231
cuccucuuug cagugccugu                                                   20


<210>  39232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39232
gcccuguuua ggaugagggu                                                   20


<210>  39233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39233
aauaaaaugu aaaauggucu                                                   20


<210>  39234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39234
accaaauuca aauaaaaugu                                                   20


<210>  39235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39235
uagaaacauu ucccuuccca                                                   20


<210>  39236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39236
aggaauucca ccaaauucaa                                                   20


<210>  39237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39237
cuucccaguu guaugaguuu                                                   20


<210>  39238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39238
caguuguaug aguuuccuau                                                   20


<210>  39239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39239
uauugcugug uaacaaagca                                                   20


<210>  39240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39240
gccacuaagu gaguggugcu                                                   20


<210>  39241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39241
gcccaacuag ggcaaauaaa                                                   20


<210>  39242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39242
uagguaucaa aagaguagga                                                   20


<210>  39243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39243
aaaucaagga ccaaaaaaaa                                                   20


<210>  39244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39244
gaauuuugaa aauguugcuu                                                   20


<210>  39245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39245
gaaaaaauca uugucuaaaa                                                   20


<210>  39246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39246
aaauuccgaa aaaaucauug                                                   20


<210>  39247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39247
aaccagacac aagacacaaa                                                   20


<210>  39248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39248
cacauccucc cacgcugcua                                                   20


<210>  39249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39249
ggggauuggg cccugguauc                                                   20


<210>  39250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39250
ggccccagga gccuccccgg                                                   20


<210>  39251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39251
guuugugguu uuuaaaucug                                                   20


<210>  39252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39252
cuuuuuaucu cuacuugaua                                                   20


<210>  39253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39253
uaaucccugc ccaagcaccu                                                   20


<210>  39254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39254
ccacuuccua aucccugccc                                                   20


<210>  39255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39255
aacagcgaua uuagcgaccc                                                   20


<210>  39256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39256
uugucacgug ggcggcuucc                                                   20


<210>  39257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39257
aggugcuuuu uuggaggcuu                                                   20


<210>  39258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39258
uccuagcucc ucauuuuagg                                                   20


<210>  39259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39259
uagcuccuca uuuuaggcaa                                                   20


<210>  39260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39260
gcuuauaguu uaauuuuuuu                                                   20


<210>  39261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39261
ccggacauca ggaccaucuc                                                   20


<210>  39262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39262
gccgaaauca gagcaauuua                                                   20


<210>  39263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39263
gcagaauauu ccccggacau                                                   20


<210>  39264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39264
ggcaauuuaa auugcucuga                                                   20


<210>  39265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39265
ccuccuucug gcaauuuaaa                                                   20


<210>  39266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39266
aaggaagaca agcugaaaca                                                   20


<210>  39267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39267
uuggaaccug ugguugcccu                                                   20


<210>  39268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39268
gcuugucuuc cuuggaaccu                                                   20


<210>  39269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39269
caacacaauc acuuacugua                                                   20


<210>  39270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39270
gcaagacucu uuaaagauca                                                   20


<210>  39271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39271
ccaccacuca cugguauuag                                                   20


<210>  39272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39272
uuuuucuuuc uuagggcacu                                                   20


<210>  39273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39273
uucuuagggc acuguuugaa                                                   20


<210>  39274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39274
uagggcacug uuugaagaag                                                   20


<210>  39275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39275
aacagugccc uaagaaagaa                                                   20


<210>  39276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39276
ucaaacagug cccuaagaaa                                                   20


<210>  39277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39277
aagaccaaga gcacgucuca                                                   20


<210>  39278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39278
gaugagcuuc caagaccaag                                                   20


<210>  39279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39279
cgcuuucggg acaggcaccc                                                   20


<210>  39280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39280
ggacaggcac ccugugugcu                                                   20


<210>  39281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39281
ugggccuccg agcuggagac                                                   20


<210>  39282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39282
uugacagcaa guaucugguc                                                   20


<210>  39283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39283
cguugauuuc auugacagca                                                   20


<210>  39284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39284
ugagaugcuu uuuucacguu                                                   20


<210>  39285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39285
cuacaucuuc augagaugcu                                                   20


<210>  39286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39286
caauuaauuu cacuacaucu                                                   20


<210>  39287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39287
cauggugauu gcugaaggcg                                                   20


<210>  39288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39288
gcaaucacca ugugaaggac                                                   20


<210>  39289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39289
aauccuguuc cagugaugaa                                                   20


<210>  39290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39290
aagcggccga cgccuucagc                                                   20


<210>  39291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39291
agugaugaag aagggggacu                                                   20


<210>  39292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39292
ucacuggaac aggauucgaa                                                   20


<210>  39293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39293
ucaucacugg aacaggauuc                                                   20


<210>  39294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39294
uagagucccc cuucuucauc                                                   20


<210>  39295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39295
uucauagagu cccccuucuu                                                   20


<210>  39296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39296
gccagccuuu uccuucauag                                                   20


<210>  39297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39297
aaagcacuag guauaaacag                                                   20


<210>  39298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39298
uccacgacuc gcucugcucu                                                   20


<210>  39299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39299
accagacugc auuuccucca                                                   20


<210>  39300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39300
auaugauuuu ugaaaacccg                                                   20


<210>  39301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39301
aaaaucauau ugaaaauucc                                                   20


<210>  39302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39302
gagcccuuga aauugaaaca                                                   20


<210>  39303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39303
agggcucuga auugcucgca                                                   20


<210>  39304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39304
auuucaaggg cucugaauug                                                   20


<210>  39305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39305
gagucggccg caacucgauu                                                   20


<210>  39306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39306
uguccaacau caaaucgagu                                                   20


<210>  39307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39307
aaggaggaaa uaucaaaagu                                                   20


<210>  39308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39308
uccuuagaaa gcauguuggg                                                   20


<210>  39309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39309
ugaugauucg guuuucagca                                                   20


<210>  39310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39310
guuuucagca uuggacuaga                                                   20


<210>  39311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39311
gcauuggacu agaaagucau                                                   20


<210>  39312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39312
aguccaaugc ugaaaaccga                                                   20


<210>  39313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39313
uuccacgagc uccaaccugg                                                   20


<210>  39314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39314
acgagcucca accuggaguc                                                   20


<210>  39315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39315
gcucugcccg caggcgccgc                                                   20


<210>  39316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39316
uggucaccag cgaguggauu                                                   20


<210>  39317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39317
cggccgggua cucggccacg                                                   20


<210>  39318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39318
gcgccgugug cccggacgac                                                   20


<210>  39319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39319
gguugguuac caugcagacg                                                   20


<210>  39320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39320
ucugcauggu aaccaacccg                                                   20


<210>  39321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39321
ugccacgugu ucauggugga                                                   20


<210>  39322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39322
ugguggaccc agacuuguuu                                                   20


<210>  39323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39323
agacagccau uggugucugg                                                   20


<210>  39324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39324
cggcguccuc ccuccccguc                                                   20


<210>  39325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39325
ucucuguccu guaccgagac                                                   20


<210>  39326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39326
ggacggggac gccgaugccc                                                   20


<210>  39327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39327
ggugggcauc ggcguccccg                                                   20


<210>  39328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39328
caaugccgcu gucacuguug                                                   20


<210>  39329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39329
accaggagga gaagagcaac                                                   20


<210>  39330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39330
ccuccuggug gaaguuccca                                                   20


<210>  39331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39331
guccggaccc cgaagggagc                                                   20


<210>  39332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39332
ggguccggac agaagggccc                                                   20


<210>  39333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39333
gggaccuaaa caagcaccua                                                   20


<210>  39334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39334
uugaggagcu cagucccccc                                                   20


<210>  39335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39335
aagaggggca ccgugggugc                                                   20


<210>  39336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39336
accagcgcug gcucccgguc                                                   20


<210>  39337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39337
accgauggcu gguccagcau                                                   20


<210>  39338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39338
cgcagccccc gcugaaugcc                                                   20


<210>  39339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39339
gcgggggcug cgcgaagcug                                                   20


<210>  39340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39340
gggcauucag cgggggcugc                                                   20


<210>  39341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39341
uggaccacuc ccucuucggg                                                   20


<210>  39342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39342
aaaggccuuc cuggaccacu                                                   20


<210>  39343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39343
auggggacca aaaaugcuuu                                                   20


<210>  39344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39344
aaagacuaag gaagauaaaa                                                   20


<210>  39345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39345
aacauuucga uggggaccaa                                                   20


<210>  39346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39346
uuagucuuuc gaacauuucg                                                   20


<210>  39347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39347
cugcacccaa ccgcacaggc                                                   20


<210>  39348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39348
agaggguucc cugcacccaa                                                   20


<210>  39349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39349
cauccugaga ccauccuaag                                                   20


<210>  39350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39350
uaggaugguc ucaggaugug                                                   20


<210>  39351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39351
gcugcucuaa cuggggaggc                                                   20


<210>  39352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39352
aggggucaug aggcggccac                                                   20


<210>  39353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39353
cccuccucug gggaggagca                                                   20


<210>  39354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39354
uugcuccucc ccagaggagg                                                   20


<210>  39355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39355
uaaaauuucc auacaaugga                                                   20


<210>  39356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39356
auacaaugga uuuuggaaau                                                   20


<210>  39357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39357
aaaauccauu guauggaaau                                                   20


<210>  39358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39358
uuuuuaaaau uuccaaaauc                                                   20


<210>  39359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39359
aaauuacacc aaucaauccu                                                   20


<210>  39360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39360
uuucaaaauu acaccaauca                                                   20


<210>  39361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39361
uucauuucaa aauuacacca                                                   20


<210>  39362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39362
uacugaauca guccccaguu                                                   20


<210>  39363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39363
guaagaaaug gcacaggcau                                                   20


<210>  39364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39364
auauuuaaua auaagcugga                                                   20


<210>  39365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39365
acaucuagga accuacccaa                                                   20


<210>  39366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39366
aguuuauauu uuugucagua                                                   20


<210>  39367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39367
cucucucucu cucucucucu                                                   20


<210>  39368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39368
auaaaaaagg gggcauucuc                                                   20


<210>  39369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39369
ccuucaauaa aaaagggggc                                                   20


<210>  39370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39370
guacaucaaa auaacacaaa                                                   20


<210>  39371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39371
uuucacccag uuuauuggca                                                   20


<210>  39372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39372
cccaguuuau uggcagguuc                                                   20


<210>  39373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39373
guggccuuug ccuuuuccag                                                   20


<210>  39374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39374
agcuuggcaa cgugagccac                                                   20


<210>  39375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39375
cagcgauggc agaucuuguc                                                   20


<210>  39376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39376
accagcuuag agcucccuug                                                   20


<210>  39377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39377
aaguuaaccu gugugaaggc                                                   20


<210>  39378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39378
cacagguuaa cuuggaagac                                                   20


<210>  39379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39379
cuugacagug cggucgggaa                                                   20


<210>  39380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39380
cgaccgcacu gucaagggaa                                                   20


<210>  39381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39381
ugccugccug cguccugaga                                                   20


<210>  39382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39382
cguucuccac caagguugug                                                   20


<210>  39383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39383
ccaccaaggu ugugacagua                                                   20


<210>  39384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39384
agcagggguu gauacuguca                                                   20


<210>  39385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39385
ucucuugcuu gucucugguu                                                   20


<210>  39386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39386
cuugcuuguc ucugguuggu                                                   20


<210>  39387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39387
cccaggccuc aggccacagg                                                   20


<210>  39388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39388
gccauucaug gaggauggcc                                                   20


<210>  39389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39389
uggaggaugg cccuuugcca                                                   20


<210>  39390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39390
gcaguggaca ggacguccag                                                   20


<210>  39391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39391
uagggcuuuc cucagacguc                                                   20


<210>  39392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39392
ucagacgucc aucuucuugg                                                   20


<210>  39393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39393
uggccaucug cugcugcaug                                                   20


<210>  39394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39394
cuuuggccuu cuucccuuuc                                                   20


<210>  39395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39395
ucccuuucag caucuuaggu                                                   20


<210>  39396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39396
cuuucagcau cuuagguagc                                                   20


<210>  39397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39397
gcaucuuagg uagcuggaga                                                   20


<210>  39398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39398
ccagcuaccu aagaugcuga                                                   20


<210>  39399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39399
uccuacccau guagcucugg                                                   20


<210>  39400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39400
uacccaugua gcucuggagu                                                   20


<210>  39401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39401
ccuuuggcag auuuuuuuau                                                   20


<210>  39402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39402
auuuuucccc uuuggcagau                                                   20


<210>  39403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39403
uuuucaauuu uuccccuuug                                                   20


<210>  39404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39404
uucauuuuca auuuuucccc                                                   20


<210>  39405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39405
cacucucuau uugaccucca                                                   20


<210>  39406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39406
ugggaggagu uuucugaaag                                                   20


<210>  39407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39407
gaaaggugau uuaugcaugc                                                   20


<210>  39408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39408
gaaaacuccu cccaagaaaa                                                   20


<210>  39409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39409
uugguucagg aaugcggcuu                                                   20


<210>  39410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39410
ggaaugcggc uuaaguuuua                                                   20


<210>  39411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39411
ugaaccaagg aauccuaucc                                                   20


<210>  39412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39412
uaucaaacaa aucaaaauaa                                                   20


<210>  39413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39413
acauaugcaa aucaauaaau                                                   20


<210>  39414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39414
acauaguacu ggaaguccua                                                   20


<210>  39415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39415
aguacuaugu ugaauaggag                                                   20


<210>  39416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39416
ucuugccuga cugcucuggc                                                   20


<210>  39417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39417
cuaauuggua ugccuuuuau                                                   20


<210>  39418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39418
uuauaccaau aaugaucuag                                                   20


<210>  39419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39419
cagcuagauc auuauuggua                                                   20


<210>  39420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39420
uucucagcua gaucauuauu                                                   20


<210>  39421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39421
uugauuucuu ucucagcuag                                                   20


<210>  39422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39422
gacaguaugg ucacuuuaau                                                   20


<210>  39423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39423
auguaauccc uaccaaaaua                                                   20


<210>  39424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39424
cggaaguaga aaacgcaauc                                                   20


<210>  39425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39425
gugaaaaauu acguagguau                                                   20


<210>  39426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39426
acuuccguga aaaauuacgu                                                   20


<210>  39427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39427
auauaaauuu uaggauugcg                                                   20


<210>  39428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39428
ggcucuuuuu ugguuccaua                                                   20


<210>  39429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39429
aagcaaaaag aacaaagcug                                                   20


<210>  39430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39430
uuuugcuuag aauugcuuug                                                   20


<210>  39431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39431
aauuauacaa ggcuguagua                                                   20


<210>  39432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39432
cuauuuuguu gucuaguuuu                                                   20


<210>  39433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39433
ggguucucua uuuuguuguc                                                   20


<210>  39434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39434
ucccccuugu cuacuaacca                                                   20


<210>  39435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39435
ccuuggaguu aaaggugacc                                                   20


<210>  39436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39436
caacaacagc accuagaaca                                                   20


<210>  39437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39437
aggugcuguu guugcgaaca                                                   20


<210>  39438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39438
aacugccagg cacuguucua                                                   20


<210>  39439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39439
aucaaaaaaa auauuaagug                                                   20


<210>  39440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39440
uucaaucaaa aaaaauauua                                                   20


<210>  39441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39441
uauucccauc auaagaaguu                                                   20


<210>  39442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39442
uuugaaggaa aaguaaaaau                                                   20


<210>  39443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39443
aaggaaguuu uuuuuuagua                                                   20


<210>  39444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39444
uucaaaggaa guuuuuuuuu                                                   20


<210>  39445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39445
uauuaaaaua auuuuuuaaa                                                   20


<210>  39446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39446
gcacauagau uuuacgcugc                                                   20


<210>  39447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39447
aguacaauga gaggaaguuu                                                   20


<210>  39448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39448
ucucauugua cuggaaaagc                                                   20


<210>  39449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39449
aaauagauug uaaaaaaaaa                                                   20


<210>  39450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39450
aaaaggguca cagcucaggc                                                   20


<210>  39451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39451
cccuuuuucc ccuuaaaguu                                                   20


<210>  39452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39452
accugaggaa gcugguugaa                                                   20


<210>  39453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39453
ucagguugaa gcauuuacaa                                                   20


<210>  39454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39454
accagcuucc ucagguugaa                                                   20


<210>  39455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39455
uugagaucau guuucugccu                                                   20


<210>  39456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39456
gccuuuugau gcuaacaugg                                                   20


<210>  39457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39457
aauaauagac cauacuugca                                                   20


<210>  39458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39458
ugagauaaac cuaacuuaug                                                   20


<210>  39459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39459
accauuaauu uuuuguuuug                                                   20


<210>  39460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39460
auuccucuuc cuucucuuuu                                                   20


<210>  39461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39461
ucuuccuucu cuuuucccuc                                                   20


<210>  39462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39462
uucucuuuuc ccucccuuuc                                                   20


<210>  39463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39463
cuuuucccuc ccuuucuucu                                                   20


<210>  39464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39464
cucccuuucu ucuccuuuuc                                                   20


<210>  39465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39465
ucuccuuuuc cucguauauu                                                   20


<210>  39466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39466
ccuuuuccuc guauauugaa                                                   20


<210>  39467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39467
ucguauauug aaucuuauau                                                   20


<210>  39468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39468
auauacgagg aaaaggagaa                                                   20


<210>  39469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39469
auaacuuuuu auuuaaaaau                                                   20


<210>  39470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39470
auuucuguuu ucgaauuguu                                                   20


<210>  39471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39471
guuuucgaau uguuacuaua                                                   20


<210>  39472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39472
aauuguuacu auaaguggca                                                   20


<210>  39473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39473
aaaacagaaa uggaaaaguu                                                   20


<210>  39474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39474
gacagcucaa gaagaagauc                                                   20


<210>  39475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39475
ugagcuguca gaacaaucug                                                   20


<210>  39476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39476
ucuugagcug ucagaacaau                                                   20


<210>  39477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39477
uccugugaau ccacuuuuuc                                                   20


<210>  39478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39478
ugugaaucca cuuuuucuag                                                   20


<210>  39479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39479
caggaagaau gcaguaauau                                                   20


<210>  39480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39480
agguucuccc ucccugcuuu                                                   20


<210>  39481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39481
cccucccugc uuucuugccu                                                   20


<210>  39482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39482
ugccuuaugu uuuguuuugu                                                   20


<210>  39483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39483
agccugguug guuuauuucc                                                   20


<210>  39484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39484
uuaguccaca cccaccuccu                                                   20


<210>  39485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39485
aaaauaucuu agggccuaug                                                   20


<210>  39486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39486
uguguaauau ucaucuuuuu                                                   20


<210>  39487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39487
aacauaaaac uagacaaacu                                                   20


<210>  39488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39488
auuucaaaca uaaaacuaga                                                   20


<210>  39489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39489
aaaauaguuu ugcuuuuggg                                                   20


<210>  39490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39490
aagcccaaaa gcaaaacuau                                                   20


<210>  39491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39491
uccugccgca cagaguuuug                                                   20


<210>  39492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39492
ugccgcacag aguuuuguaa                                                   20


<210>  39493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39493
ugugauauua uuuagauugc                                                   20


<210>  39494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39494
augcccgcaa uaaaucaucc                                                   20


<210>  39495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39495
uuccaugccc gcaauaaauc                                                   20


<210>  39496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39496
aaaaugugua ugucagcauc                                                   20


<210>  39497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39497
ugcggcugag ggccaagggc                                                   20


<210>  39498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39498
ggggugugug cucuuucccc                                                   20


<210>  39499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39499
ccuuccuggc caaugagagg                                                   20


<210>  39500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39500
uggccaauga gaggacagug                                                   20


<210>  39501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39501
cuguccucuc auuggccagg                                                   20


<210>  39502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39502
cuacugggaa guggguuggg                                                   20


<210>  39503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39503
caguagugaa aacacacagc                                                   20


<210>  39504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39504
gaggguccug ccccccaacc                                                   20


<210>  39505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39505
gcacauccug ucugaccacc                                                   20


<210>  39506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39506
agugggugua ccgcucgugu                                                   20


<210>  39507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39507
agcugcugcc ccuaccgugu                                                   20


<210>  39508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39508
uugguccccu cccccuuggg                                                   20


<210>  39509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39509
ucugggccuc acuuguuugg                                                   20


<210>  39510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39510
cgggaguggc caggagguac                                                   20


<210>  39511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39511
cguucgcucc ccuggcccug                                                   20


<210>  39512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39512
cuccccuggc ccuggcagcc                                                   20


<210>  39513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39513
guccuccucu cugccaaggc                                                   20


<210>  39514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39514
ugcggggacc ucccagacgg                                                   20


<210>  39515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39515
ugccuagaua gcagcagagu                                                   20


<210>  39516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39516
gcucaccccc ucucacuucc                                                   20


<210>  39517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39517
uggcauccgu guccccuggu                                                   20


<210>  39518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39518
gauuccucuc cuuccugggc                                                   20


<210>  39519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39519
ucuccuuccu gggcugaguc                                                   20


<210>  39520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39520
ugggcugagu ccugggcuug                                                   20


<210>  39521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39521
ugccagugca gugccagguc                                                   20


<210>  39522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39522
uguucuuuuc ggcuuccucc                                                   20


<210>  39523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39523
uuucggcuuc cuccuggcuc                                                   20


<210>  39524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39524
gcuuccuccu ggcucagcug                                                   20


<210>  39525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39525
uccuggcuca gcugacuguc                                                   20


<210>  39526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39526
cggccuccuc cuggucacgc                                                   20


<210>  39527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39527
gguaccgccu gccaccccuc                                                   20


<210>  39528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39528
uaacuugacu ugucuguucu                                                   20


<210>  39529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39529
ugucccuggu gccuuuaagc                                                   20


<210>  39530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39530
acuguuccaa gccccuuccu                                                   20


<210>  39531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39531
aagccccuuc cucggaggcg                                                   20


<210>  39532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39532
ucggaggcgu cuccccaacc                                                   20


<210>  39533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39533
acuccugugg gagggcagug                                                   20


<210>  39534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39534
guagcaucau gcccuguaag                                                   20


<210>  39535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39535
caaacuucag uagcaucaug                                                   20


<210>  39536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39536
uugacgcugu uacuaagacu                                                   20


<210>  39537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39537
uuucacauga aaaggaugac                                                   20


<210>  39538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39538
caugaaaagg augacuuccu                                                   20


<210>  39539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39539
ugugaaaaga acagauccca                                                   20


<210>  39540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39540
ucuuguuggg ugucaccuag                                                   20


<210>  39541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39541
cgggacaccu ccaccuggag                                                   20


<210>  39542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39542
cagaggcacu cuccaggugg                                                   20


<210>  39543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39543
ucagauggac uuuucguuuc                                                   20


<210>  39544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39544
uuuccuggag uuuugucaug                                                   20


<210>  39545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39545
uggaguuuug ucaugaggcu                                                   20


<210>  39546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39546
uucagucugc aacugugucu                                                   20


<210>  39547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39547
gucugcaacu gugucugaug                                                   20


<210>  39548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39548
gauguauaua uuuuuuauuu                                                   20


<210>  39549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39549
uaaaguuuuc aaauugugaa                                                   20


<210>  39550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39550
aauugugaaa guguauuugc                                                   20


<210>  39551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39551
caauuugaaa acuuuaugaa                                                   20


<210>  39552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39552
ugagggcauc aaauggcaaa                                                   20


<210>  39553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39553
cugucuccuu gugggcgggu                                                   20


<210>  39554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39554
aggugaguua auucuggggg                                                   20


<210>  39555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39555
gggggcgcuu ucugugacac                                                   20


<210>  39556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39556
gugacaccca gguggccucg                                                   20


<210>  39557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39557
aaaacacacg ccgaggccac                                                   20


<210>  39558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39558
cuuaacaaac agcuuccaaa                                                   20


<210>  39559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39559
gggccauggc aguucucuua                                                   20


<210>  39560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39560
cuuguuguau aaccagcuuu                                                   20


<210>  39561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39561
aagugcuuuc ugaauuugag                                                   20


<210>  39562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39562
gaauuugagc aauucaggaa                                                   20


<210>  39563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39563
gaaagcacuu ugaaaucuua                                                   20


<210>  39564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39564
ggaaauuugg gugagaccca                                                   20


<210>  39565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39565
ugaauugcuc aaauucagaa                                                   20


<210>  39566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39566
gggucucacc caaauuuccu                                                   20


<210>  39567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39567
caagaaaagu auaauagacg                                                   20


<210>  39568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39568
ugagaaaauu cugggucuca                                                   20


<210>  39569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39569
ucuauuauac uuuucuugag                                                   20


<210>  39570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39570
ucccacacuc ucaauucguc                                                   20


<210>  39571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39571
ucuucauccc acacucucaa                                                   20


<210>  39572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39572
guguuuaaag aauuuugugc                                                   20


<210>  39573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39573
uuaaacacag aaaguaaguu                                                   20


<210>  39574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39574
uuucauggac ugauugaaaa                                                   20


<210>  39575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39575
uggacugauu gaaaaggaag                                                   20


<210>  39576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39576
aucaguccau gaaaagaauc                                                   20


<210>  39577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39577
uuuucaauca guccaugaaa                                                   20


<210>  39578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39578
ugccuacuuc cuuuucaauc                                                   20


<210>  39579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39579
cugaagauuu cucugauguc                                                   20


<210>  39580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39580
gugaaauaag acauuccugc                                                   20


<210>  39581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39581
cugaugucau ccuuaucauu                                                   20


<210>  39582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39582
augauuuaaa aaaaccucuc                                                   20


<210>  39583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39583
uccgaaauau uccucuuuuc                                                   20


<210>  39584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39584
gaggaacucu ccuuacuuug                                                   20


<210>  39585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39585
ucuuuucuuc uaacacuccu                                                   20


<210>  39586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39586
ucuaacacuc cugacagucc                                                   20


<210>  39587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39587
aacacuccug acaguccgca                                                   20


<210>  39588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39588
ucgucaccuc acgcuuuugu                                                   20


<210>  39589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39589
gucccugaga gcuggaauag                                                   20


<210>  39590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39590
agcucucagg gacagaagug                                                   20


<210>  39591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39591
gcagcacagc cugugccuca                                                   20


<210>  39592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39592
cuuuaacgca caaauacagu                                                   20


<210>  39593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39593
cucacuuucu gugguccugc                                                   20


<210>  39594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39594
gugguccugc agcugcuggc                                                   20


<210>  39595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39595
gaggccgagg acugaggcca                                                   20


<210>  39596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39596
uacagagugg cuggccugcg                                                   20


<210>  39597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39597
ggugccagug cguguguaac                                                   20


<210>  39598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39598
acaaaauaca ucuccaccac                                                   20


<210>  39599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39599
uuuuauucua caaaauacau                                                   20


<210>  39600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39600
auuuccuauu uuauguacaa                                                   20


<210>  39601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39601
uauuuuaugu acaaugaaaa                                                   20


<210>  39602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39602
uuguacauaa aauaggaaau                                                   20


<210>  39603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39603
uuaaugaaaa gaaacaggac                                                   20


<210>  39604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39604
uuaaggaagu uuauccuccc                                                   20


<210>  39605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39605
uuucauuaag gaaguuuauc                                                   20


<210>  39606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39606
ggguccuguu ucuuuucauu                                                   20


<210>  39607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39607
aaacaccggu cacuuuaucc                                                   20


<210>  39608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39608
ugcuuucucu uucugccgug                                                   20


<210>  39609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39609
cuuucugccg uguucucacu                                                   20


<210>  39610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39610
gccguguucu cacuucuccu                                                   20


<210>  39611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39611
cacuucuccu uucuggcaga                                                   20


<210>  39612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39612
ccuuucuggc agaagacauu                                                   20


<210>  39613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39613
ggcagaagac auucauuucu                                                   20


<210>  39614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39614
gccagaaagg agaagugaga                                                   20


<210>  39615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39615
uuucuugcag gcaauuuaua                                                   20


<210>  39616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39616
ugcaggcaau uuauacauga                                                   20


<210>  39617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39617
uguauaaauu gccugcaaga                                                   20


<210>  39618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39618
ccauauauaa uaaguuuuau                                                   20


<210>  39619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39619
gucagcaaua gaugcaggaa                                                   20


<210>  39620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39620
ugcaucuauu gcugacagaa                                                   20


<210>  39621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39621
cacccuuggg aggugcaggu                                                   20


<210>  39622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39622
ucagagggac acacagagcc                                                   20


<210>  39623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39623
ucagagggac acacagagcc                                                   20


<210>  39624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39624
acccccugcu ccuccuucuu                                                   20


<210>  39625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39625
uuucccagug ucagacccug                                                   20


<210>  39626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39626
cagugucaga cccuggggcc                                                   20


<210>  39627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39627
gggugugcug augacugucu                                                   20


<210>  39628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39628
ggaaccgcag ugggcgggcu                                                   20


<210>  39629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39629
ugaaauucag ggugugcuga                                                   20


<210>  39630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39630
uuuuuguguu uuuguuauuu                                                   20


<210>  39631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39631
aucuucaguu ucuuugcuua                                                   20


<210>  39632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39632
guuucuuugc uuauaagagu                                                   20


<210>  39633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39633
uugcuuauaa gaguaaaaag                                                   20


<210>  39634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39634
gccguuguua gauguagggc                                                   20


<210>  39635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39635
ccugcaggcc ugagucuggc                                                   20


<210>  39636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39636
ggugccucag gcagaaagag                                                   20


<210>  39637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39637
gccugaggca ccagaagggg                                                   20


<210>  39638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39638
cugggaccac ccccccaccc                                                   20


<210>  39639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39639
acacagagau cuuuuuauag                                                   20


<210>  39640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39640
caggcccacc ucagugcacu                                                   20


<210>  39641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39641
cauaaaaaca cuggggugcu                                                   20


<210>  39642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39642
aaggagggac ugaggaguug                                                   20


<210>  39643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39643
aagugaguga ucuauuaauc                                                   20


<210>  39644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39644
acgagccgug ccagugagag                                                   20


<210>  39645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39645
uguucaugcc acgguuucau                                                   20


<210>  39646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39646
ugccacgguu ucauucugug                                                   20


<210>  39647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39647
uucugugacg cguaucgugc                                                   20


<210>  39648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39648
gugacgcgua ucgugcuuuu                                                   20


<210>  39649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39649
uuaaaaccga gccacaaaac                                                   20


<210>  39650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39650
cuuuuucaga agaaaggggc                                                   20


<210>  39651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39651
gaagaaaggg gcugauaaug                                                   20


<210>  39652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39652
gaaaaaguga aaaaacacac                                                   20


<210>  39653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39653
ucugaaaaag ugaaaaaaca                                                   20


<210>  39654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39654
cgagggcacu cuuuggcuac                                                   20


<210>  39655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39655
agcuggagag aaggaagcac                                                   20


<210>  39656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39656
cuccagcugg aaucugcucc                                                   20


<210>  39657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39657
uucucuccag cuggaaucug                                                   20


<210>  39658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39658
agcauuauag agaggcuuag                                                   20


<210>  39659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39659
ccugcuaagc cucucuauaa                                                   20


<210>  39660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39660
cacaaggcag accauucccc                                                   20


<210>  39661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39661
gacagaagug ugaggucgag                                                   20


<210>  39662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39662
gucugaauaa cuucccacaa                                                   20


<210>  39663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39663
caacgcccca ucucccucca                                                   20


<210>  39664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39664
ucacaacgcc ccaucucccu                                                   20


<210>  39665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39665
cauuucuuca caacgcccca                                                   20


<210>  39666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39666
uuuucucauu ucuucacaac                                                   20


<210>  39667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39667
aggagcaacc gggcaucuuc                                                   20


<210>  39668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39668
uuuuuccagg agcaaccggg                                                   20


<210>  39669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39669
gugcggccgc ggcuccagcu                                                   20


<210>  39670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39670
uguggcuucc uccguugguc                                                   20


<210>  39671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39671
uccguugguc aagcucugug                                                   20


<210>  39672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39672
ggcaggccuc uuggcacaga                                                   20


<210>  39673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39673
cgcugugacc accucaccuu                                                   20


<210>  39674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39674
gaagucgggg uguggagacu                                                   20


<210>  39675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39675
gaaggugagg uggucacagc                                                   20


<210>  39676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39676
ugcuggcaca gacgccguac                                                   20


<210>  39677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39677
ccggcuuucc ugcuggcaca                                                   20


<210>  39678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39678
caaacacucc guucucgcag                                                   20


<210>  39679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39679
cgcagccuca cccuggggac                                                   20


<210>  39680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39680
ccugaacgcu ggugguugcc                                                   20


<210>  39681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39681
ggagaaggga gcgggaggau                                                   20


<210>  39682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39682
cccaaccauc cugcguccca                                                   20


<210>  39683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39683
cucuucccuu ccugaccacc                                                   20


<210>  39684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39684
cuuccugacc accugccccc                                                   20


<210>  39685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39685
ugaccaccug cccccauccu                                                   20


<210>  39686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39686
ugcccgugcu aggggcagcu                                                   20


<210>  39687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39687
aucauuuuaa uuauucaucu                                                   20


<210>  39688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39688
ucuguguugg ugcuuuuguc                                                   20


<210>  39689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39689
cucaacagac agcucucgug                                                   20


<210>  39690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39690
gcagacauca gccagagcgu                                                   20


<210>  39691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39691
gugauuuucc uuuuagucgu                                                   20


<210>  39692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39692
uuuuagucgu gaaaccuucu                                                   20


<210>  39693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39693
cgacuaaaag gaaaaucacu                                                   20


<210>  39694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39694
caaaaagcac acacaagcac                                                   20


<210>  39695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39695
gugcuugugu gugcuuuuug                                                   20


<210>  39696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39696
gcuucugugc uugugugugc                                                   20


<210>  39697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39697
agugccuuca cccaacacgc                                                   20


<210>  39698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39698
cccaacacgc gggccuuugg                                                   20


<210>  39699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39699
gccauggcca ggucugagcu                                                   20


<210>  39700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39700
ggcuccaccu gcagcuccac                                                   20


<210>  39701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39701
cucuccuagc cuugugucuu                                                   20


<210>  39702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39702
ucucgccggu ccuuguuagc                                                   20


<210>  39703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39703
cuaacaagga ccggcgagau                                                   20


<210>  39704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39704
ucuuuaaaau auaaaguaua                                                   20


<210>  39705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39705
cuuugucuga uauuaauauu                                                   20


<210>  39706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39706
uuuuauugcu uuuucacuuu                                                   20


<210>  39707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39707
gcaaaucuca ugcuacuuuu                                                   20


<210>  39708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39708
guucugcaaa ucucaugcua                                                   20


<210>  39709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39709
cccucggagu acuuacccau                                                   20


<210>  39710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39710
gaaaccaaga gaucaagcug                                                   20


<210>  39711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39711
gaaaaaggug uguaauaauu                                                   20


<210>  39712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39712
gcuugaucuc uugguuucug                                                   20


<210>  39713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39713
cauacuuugu aaucuuacua                                                   20


<210>  39714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39714
auucacauac uuuguaaucu                                                   20


<210>  39715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39715
auuugguaca aagcucucua                                                   20


<210>  39716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39716
aaaguacgug gaacauuuac                                                   20


<210>  39717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39717
acguacuuua gaaaaaaagu                                                   20


<210>  39718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39718
cuguaugcua uaauuuuuuu                                                   20


<210>  39719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39719
aauacacugc ugucaggagc                                                   20


<210>  39720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39720
auucaaauac acugcuguca                                                   20


<210>  39721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39721
uuuuuguuau cauuuuauga                                                   20


<210>  39722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39722
uacauuuuaa aguuuaaaac                                                   20


<210>  39723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39723
aaauaaucca ugggucaagg                                                   20


<210>  39724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39724
uugacccaug gauuauuuag                                                   20


<210>  39725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39725
uccuugaccc auggauuauu                                                   20


<210>  39726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39726
aaacuguaug auaacuccca                                                   20


<210>  39727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39727
auacuacaca ucaucaccag                                                   20


<210>  39728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39728
acuggugaug auguguagua                                                   20


<210>  39729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39729
gugaaaaaau uguagcauua                                                   20


<210>  39730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39730
cugaaaauca cuuugauuau                                                   20


<210>  39731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39731
aauauauaca uuuaaugcua                                                   20


<210>  39732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39732
aacuuuuuuc uaauauauac                                                   20


<210>  39733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39733
uauauuuuca aacuuuuuuc                                                   20


<210>  39734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39734
acagaagcaa guacggaaaa                                                   20


<210>  39735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39735
guugaaaacu uauuuccuau                                                   20


<210>  39736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39736
guacuugcuu cuguugaaaa                                                   20


<210>  39737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39737
uuuuuuccgu acuugcuucu                                                   20


<210>  39738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39738
uuaauuugca uuuccuuuuu                                                   20


<210>  39739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39739
uuuccuuaau uugcauuucc                                                   20


<210>  39740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39740
gcauuuaucu ucauuuccuu                                                   20


<210>  39741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39741
auuuugauaa uuucugcauu                                                   20


<210>  39742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39742
uacuuuuagu uguauacugu                                                   20


<210>  39743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39743
ugauuauacu uuuguucaua                                                   20


<210>  39744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39744
ugggcccaag ugauccuccu                                                   20


<210>  39745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39745
uuuuuuguag agaugguguu                                                   20


<210>  39746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39746
ucuuuuucuu uuuuuguaga                                                   20


<210>  39747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39747
ugauguuauc uuuguccucu                                                   20


<210>  39748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39748
uucuugaugu uaucuuuguc                                                   20


<210>  39749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39749
uagucucuaa cuguacuuag                                                   20


<210>  39750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39750
auuaacaacu uuauacugua                                                   20


<210>  39751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39751
uaaagauugu ccgguuaauc                                                   20


<210>  39752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39752
uaggccaacu uugaucauuu                                                   20


<210>  39753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39753
ucuuaggcca acuuugauca                                                   20


<210>  39754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39754
acuucuucuu aggccaacuu                                                   20


<210>  39755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39755
aaaucauuuu ugccuauguu                                                   20


<210>  39756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39756
uuucuuacac uacauuacau                                                   20


<210>  39757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39757
uacacuacau uacaugccua                                                   20


<210>  39758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39758
aaguguuuuc cuccaggagc                                                   20


<210>  39759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39759
uccaggagcc aggcuauugg                                                   20


<210>  39760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39760
uaaauggggc acugcaggcc                                                   20


<210>  39761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39761
cucggccaca aggccugcag                                                   20


<210>  39762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39762
gcccugccgu cuuuucccuc                                                   20


<210>  39763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39763
cauucauugg ccaaagcaua                                                   20


<210>  39764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39764
uuggccaaag cauaacacau                                                   20


<210>  39765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39765
uauaaagcug ggauaauaac                                                   20


<210>  39766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39766
cacgcugucc cugugaaguc                                                   20


<210>  39767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39767
cagggacagc gugagaacuc                                                   20


<210>  39768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39768
ucacugggca agacacuccc                                                   20


<210>  39769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39769
agagucacac uguuuggauc                                                   20


<210>  39770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39770
cggcgugguu ccagagucac                                                   20


<210>  39771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39771
aggaggugga uccucagccu                                                   20


<210>  39772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39772
caggugcuga cgggaugucu                                                   20


<210>  39773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39773
cacgauucac aggugcugac                                                   20


<210>  39774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39774
uaaaaccggg ugggcaaguu                                                   20


<210>  39775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39775
cuuccuaaaa ccgggugggc                                                   20


<210>  39776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39776
gcccauucuc uuccuaaaac                                                   20


<210>  39777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39777
ccauggagga gagcccugcc                                                   20


<210>  39778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39778
ccuugcugac uguggagagg                                                   20


<210>  39779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39779
caggggugga gcuggggcuc                                                   20


<210>  39780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39780
aaaaaucugg ucaccaugcu                                                   20


<210>  39781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39781
gauaucaaac aaucaaacuu                                                   20


<210>  39782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39782
cauaauuuua auaauaaaua                                                   20


<210>  39783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39783
gugucuugug uuaccucuuu                                                   20


<210>  39784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39784
uccuucccug aagccugguc                                                   20


<210>  39785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39785
cugaagccug guccucuggc                                                   20


<210>  39786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39786
gggaaggagg aagggccuga                                                   20


<210>  39787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39787
uccucucuau cccuggacuc                                                   20


<210>  39788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39788
guggaagcac agguccccag                                                   20


<210>  39789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39789
acugaaagag uccagggaua                                                   20


<210>  39790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39790
guuuucugug uggguggccc                                                   20


<210>  39791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39791
gugugggugg ccccaccuug                                                   20


<210>  39792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39792
cucaagccaa gguggggcca                                                   20


<210>  39793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39793
ucaugagguc agcauuuggg                                                   20


<210>  39794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39794
gcauugggug gcguccucug                                                   20


<210>  39795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39795
gguuguggcu uggccccacc                                                   20


<210>  39796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39796
gaccuucugg uuguggcuug                                                   20


<210>  39797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39797
uguguggcca cuggcacaag                                                   20


<210>  39798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39798
ugugccagug gccacacagg                                                   20


<210>  39799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39799
auucuugugc caguggccac                                                   20


<210>  39800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39800
ucuauucuug ugccaguggc                                                   20


<210>  39801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39801
ucuucuauuc uugugccagu                                                   20


<210>  39802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39802
ucaaaaugaa guaagucagu                                                   20


<210>  39803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39803
uuuugaugaa uaaaauauuu                                                   20


<210>  39804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39804
caaaggaauu aaccacuaaa                                                   20


<210>  39805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39805
uuugugaaac ugacuuacuu                                                   20


<210>  39806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39806
cauuacucau uuagugguua                                                   20


<210>  39807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39807
gcucaaguaa gcauaauaaa                                                   20


<210>  39808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39808
uuuauuaugc uuacuugagc                                                   20


<210>  39809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39809
aagaucaacc cuaacugacu                                                   20


<210>  39810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39810
gugucuuuuc uuggagcauc                                                   20


<210>  39811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39811
uggagcaucc ugagggcucc                                                   20


<210>  39812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39812
aggcuuagag cuaccaacua                                                   20


<210>  39813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39813
gagugacaag ugacauaauu                                                   20


<210>  39814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39814
cucgucuuug cacaucgccu                                                   20


<210>  39815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39815
cacacugacc uucgcaggag                                                   20


<210>  39816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39816
caggagccgc ucugcucacu                                                   20


<210>  39817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39817
cccccgccug uuggcauuuc                                                   20


<210>  39818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39818
cucuccagaa ggacuuggug                                                   20


<210>  39819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39819
ggagagugaa augccaacag                                                   20


<210>  39820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39820
gacguagaga guuuguuuug                                                   20


<210>  39821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39821
ggcagagccc agcaaaacaa                                                   20


<210>  39822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39822
aguacugacu ccaggaaaga                                                   20


<210>  39823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39823
uggagucagu acuagaaacg                                                   20


<210>  39824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39824
gggucuuucc uggagucagu                                                   20


<210>  39825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39825
gauuucuccu guuugggccc                                                   20


<210>  39826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39826
ccuguuuggg cccacauuuc                                                   20


<210>  39827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39827
ucuggcccuc ugagguaacg                                                   20


<210>  39828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39828
ggcccucuga gguaacggga                                                   20


<210>  39829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39829
cguuaccuca gagggccaga                                                   20


<210>  39830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39830
gggcugaccg ugagucuggc                                                   20


<210>  39831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39831
ccauggugag gucccgguau                                                   20


<210>  39832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39832
augaccugcc ugggcugaca                                                   20


<210>  39833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39833
ucuguaaaau gggcugauug                                                   20


<210>  39834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39834
gaggaggugc uauuccagau                                                   20


<210>  39835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39835
agaucccugu uuucuaaccc                                                   20


<210>  39836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39836
aacccucagc aggcucugcu                                                   20


<210>  39837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39837
ugcccgacau guccuccuuc                                                   20


<210>  39838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39838
uccgcaagcc agccccucac                                                   20


<210>  39839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39839
acuguguccc cacccaaauc                                                   20


<210>  39840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39840
ggccugccca uaggaugccu                                                   20


<210>  39841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39841
acccaugccu uacuggccag                                                   20


<210>  39842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39842
ggccaguaag gcaugggugg                                                   20


<210>  39843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39843
caguaccacc accccgcccc                                                   20


<210>  39844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39844
cucccacaca ccaggccacu                                                   20


<210>  39845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39845
aaggggauga uggggaccag                                                   20


<210>  39846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39846
aaggugauuc caaggggaug                                                   20


<210>  39847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39847
aaaugaucca ggguuuucca                                                   20


<210>  39848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39848
accuugauac ugugaugagc                                                   20


<210>  39849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39849
ucuucuaccu ugauacugug                                                   20


<210>  39850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39850
gccaccaugu gaucuuacug                                                   20


<210>  39851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39851
aaggagccca cagucucagg                                                   20


<210>  39852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39852
ggauguggcu cuguuuucac                                                   20


<210>  39853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39853
cugccuacca gcucuccagc                                                   20


<210>  39854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39854
ccuugguucu uggagaccug                                                   20


<210>  39855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39855
uggagaccug auuugcuucc                                                   20


<210>  39856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39856
aaucaacccc uuccuacuca                                                   20


<210>  39857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39857
uacucagugg ccagccuauu                                                   20


<210>  39858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39858
ccauuugcaa ccagcaaccc                                                   20


<210>  39859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39859
ggggaaacuu cuggcuauaa                                                   20


<210>  39860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39860
ccagaaguua uagccagggu                                                   20


<210>  39861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39861
ggcuauaacu ucugaggcac                                                   20


<210>  39862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39862
gaggcacgga gcggggcagg                                                   20


<210>  39863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39863
ugcaggagga ggagguggcc                                                   20


<210>  39864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39864
uccaccuuuc agcagcccug                                                   20


<210>  39865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39865
gcagcccugg agccgcaugg                                                   20


<210>  39866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39866
cugcuccaug cggcuccagg                                                   20


<210>  39867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39867
aggcugugug ggagcaggug                                                   20


<210>  39868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39868
ugagugcugg cccgggccca                                                   20


<210>  39869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39869
ugcuccccac acaucccagg                                                   20


<210>  39870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39870
gcggaaggcg gcugguggcu                                                   20


<210>  39871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39871
gcagaacagu ugcuggguca                                                   20


<210>  39872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39872
gcuuccuggg ccuggugucc                                                   20


<210>  39873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39873
ugggccuggu gucccccgcc                                                   20


<210>  39874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39874
gugaugucuu gucagggccu                                                   20


<210>  39875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39875
auuugcuccu cagugcgagg                                                   20


<210>  39876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39876
ucccauccag acccuaggcu                                                   20


<210>  39877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39877
uuucauccca uccagacccu                                                   20


<210>  39878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39878
uucuucuccc ccgagaaccg                                                   20


<210>  39879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39879
ucucccccga gaaccgucag                                                   20


<210>  39880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39880
cccccgagaa ccgucagccc                                                   20


<210>  39881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39881
cgggggagaa gaaggaaggg                                                   20


<210>  39882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39882
agggugccau cgccccuccc                                                   20


<210>  39883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39883
cguaucugcu gggugucccc                                                   20


<210>  39884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39884
gcagagaggc caugugcuuu                                                   20


<210>  39885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39885
ucugcagaga ggccaugugc                                                   20


<210>  39886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39886
ggacuccccc uccuugaccc                                                   20


<210>  39887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39887
gcccccaucc caggcaagag                                                   20


<210>  39888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39888
cauuaaaagc cugcagggac                                                   20


<210>  39889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39889
guucccauua aaagccugca                                                   20


<210>  39890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39890
uccauuucug uucccauuaa                                                   20


<210>  39891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39891
cccacacuga ggugaccccu                                                   20


<210>  39892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39892
cagacuggca ucugccccua                                                   20


<210>  39893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39893
aacaauccgg cuucccagac                                                   20


<210>  39894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39894
aaaagcagag acaaccaccu                                                   20


<210>  39895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39895
uuuucaaaaa gcagagacaa                                                   20


<210>  39896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39896
ccugcgggcg gcucccccac                                                   20


<210>  39897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39897
aaauagcucg cagggcccug                                                   20


<210>  39898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39898
gcgccgccgc gcucgccccg                                                   20


<210>  39899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39899
gucaugguuc cgcgccgccg                                                   20


<210>  39900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39900
ugccgucccg cagcuugacc                                                   20


<210>  39901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39901
acugcgggga caggggggag                                                   20


<210>  39902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39902
gcagcaccag ccaccuacuc                                                   20


<210>  39903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39903
cggcggggug acagcggcgg                                                   20


<210>  39904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39904
guccagggcc cccaccugcg                                                   20


<210>  39905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39905
uccguccagg gcccccaccu                                                   20


<210>  39906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39906
agcagggcag acugaggccc                                                   20


<210>  39907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39907
ggggggcccc uugcugcucu                                                   20


<210>  39908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39908
acaagcacag cucaacccuc                                                   20


<210>  39909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39909
ggggcccugc ucugagcguu                                                   20


<210>  39910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39910
cccagcaaug uggcagucac                                                   20


<210>  39911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39911
uccaggacca ccugaggccc                                                   20


<210>  39912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39912
ugccugccuc cgccuccccu                                                   20


<210>  39913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39913
ccacucagcc cuccgugccc                                                   20


<210>  39914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39914
uauaccaggu ccccugcagc                                                   20


<210>  39915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39915
ugggaugcgg ccucucugga                                                   20


<210>  39916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39916
cccccgacac uccucuuugg                                                   20


<210>  39917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39917
uucugcauca gacaguccca                                                   20


<210>  39918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39918
gcaucagaca gucccaggag                                                   20


<210>  39919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39919
ccuacagacu cacagauugu                                                   20


<210>  39920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39920
ggggcuggcg ugggagguga                                                   20


<210>  39921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39921
acuaccccac aucaccuccc                                                   20


<210>  39922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39922
uuccaagccu ugaggccagg                                                   20


<210>  39923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39923
aagccuugag gccagguguc                                                   20


<210>  39924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39924
guguugguca cuccagcagc                                                   20


<210>  39925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39925
acccugggcu gcuggaguga                                                   20


<210>  39926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39926
cacgcccacc uccccacccu                                                   20


<210>  39927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39927
ccuggccccu cauaagccuc                                                   20


<210>  39928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39928
cccagcugcc uucccgcuca                                                   20


<210>  39929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39929
cgcucagcgc uggagaccac                                                   20


<210>  39930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39930
ucucucccuc acaccaggag                                                   20


<210>  39931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39931
uuguaagaca ggcaggguuc                                                   20


<210>  39932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39932
uuuuguuacc aguggugauu                                                   20


<210>  39933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39933
uucugggaag ggccccgaug                                                   20


<210>  39934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39934
gggaagggcc ccgaugugca                                                   20


<210>  39935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39935
cagaaggaaa ucaccacugg                                                   20


<210>  39936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39936
acuggcaccu uucuccuccu                                                   20


<210>  39937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39937
ccuccuugcg uuuuucucaa                                                   20


<210>  39938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39938
caaucgugag cacgucuuuc                                                   20


<210>  39939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39939
guuaugacaa gguuuagcga                                                   20


<210>  39940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39940
cuaaaccuug ucauaacaga                                                   20


<210>  39941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39941
uucgcuaaac cuugucauaa                                                   20


<210>  39942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39942
cuuucauucg cuaaaccuug                                                   20


<210>  39943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39943
ucaaugucuc caccgcgucc                                                   20


<210>  39944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39944
gcagugagga cgcgguggag                                                   20


<210>  39945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39945
uccucccagg ugcgggggcu                                                   20


<210>  39946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39946
ucccaggugc gggggcuggg                                                   20


<210>  39947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39947
ucaccacccc cagcccccgc                                                   20


<210>  39948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39948
ugacauccug uggagagugu                                                   20


<210>  39949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39949
cacaggggcu gccccugggg                                                   20


<210>  39950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39950
uccagcucag aaaagccacc                                                   20


<210>  39951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39951
gagcuggaug aagcccccag                                                   20


<210>  39952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39952
ccccaccaug gugacuccaa                                                   20


<210>  39953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39953
gcuucccccc accaugguga                                                   20


<210>  39954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39954
gaguuucagc uuccccccac                                                   20


<210>  39955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39955
ccccagccag cccaaaccuu                                                   20


<210>  39956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39956
agccagcugu ggggggcaag                                                   20


<210>  39957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39957
gcgccugccc ccgggcugau                                                   20


<210>  39958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39958
ugagcagagc cuccuggugg                                                   20


<210>  39959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39959
ugugcgucug gcuccugccc                                                   20


<210>  39960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39960
gcccggagcu gggaugucag                                                   20


<210>  39961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39961
auggggagag gauaacuggc                                                   20


<210>  39962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39962
ugauguuucu auggggagag                                                   20


<210>  39963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39963
cucagccccc gcgucaggac                                                   20


<210>  39964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39964
cuguccugac gcgggggcug                                                   20


<210>  39965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39965
gcucucagcu ccacaugugg                                                   20


<210>  39966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer sequence TTCN PAM

<400>  39966
ccgccugcgu ccucgucuac                                                   20


<210>  39967
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplast transit peptide

<400>  39967

Met Ala Ser Met Ile Ser Ser Ser Ala Val Thr Thr Val Ser Arg Ala 
1               5                   10                  15      


Ser Arg Gly Gln Ser Ala Ala Met Ala Pro Phe Gly Gly Leu Lys Ser 
            20                  25                  30          


Met Thr Gly Phe Pro Val Arg Lys Val Asn Thr Asp Ile Thr Ser Ile 
        35                  40                  45              


Thr Ser Asn Gly Gly Arg Val Lys Cys Met Gln Val Trp Pro Pro Ile 
    50                  55                  60                  


Gly Lys Lys Lys Phe Glu Thr Leu Ser Tyr Leu Pro Pro Leu Thr Arg 
65                  70                  75                  80  


Asp Ser Arg Ala 
                


<210>  39968
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplast transit peptide

<400>  39968

Met Ala Ser Ser Met Leu Ser Ser Ala Thr Met Val Ala Ser Pro Ala 
1               5                   10                  15      


Gln Ala Thr Met Val Ala Pro Phe Asn Gly Leu Lys Ser Ser Ala Ala 
            20                  25                  30          


Phe Pro Ala Thr Arg Lys Ala Asn Asn Asp Ile Thr Ser Ile Thr Ser 
        35                  40                  45              


Asn Gly Gly Arg Val Asn Cys Met Gln Val Trp Pro Pro Ile Glu Lys 
    50                  55                  60                  


Lys Lys Phe Glu Thr Leu Ser Tyr Leu Pro Asp Leu Thr Asp Ser Gly 
65                  70                  75                  80  


Gly Arg Val Asn Cys 
                85  


<210>  39969
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplast transit peptide

<400>  39969

Met Ala Gln Val Ser Arg Ile Cys Asn Gly Val Gln Asn Pro Ser Leu 
1               5                   10                  15      


Ile Ser Asn Leu Ser Lys Ser Ser Gln Arg Lys Ser Pro Leu Ser Val 
            20                  25                  30          


Ser Leu Lys Thr Gln Gln His Pro Arg Ala Tyr Pro Ile Ser Ser Ser 
        35                  40                  45              


Trp Gly Leu Lys Lys Ser Gly Met Thr Leu Ile Gly Ser Glu Leu Arg 
    50                  55                  60                  


Pro Leu Lys Val Met Ser Ser Val Ser Thr Ala Cys 
65                  70                  75      


<210>  39970
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplast transit peptide

<400>  39970

Met Ala Gln Val Ser Arg Ile Cys Asn Gly Val Trp Asn Pro Ser Leu 
1               5                   10                  15      


Ile Ser Asn Leu Ser Lys Ser Ser Gln Arg Lys Ser Pro Leu Ser Val 
            20                  25                  30          


Ser Leu Lys Thr Gln Gln His Pro Arg Ala Tyr Pro Ile Ser Ser Ser 
        35                  40                  45              


Trp Gly Leu Lys Lys Ser Gly Met Thr Leu Ile Gly Ser Glu Leu Arg 
    50                  55                  60                  


Pro Leu Lys Val Met Ser Ser Val Ser Thr Ala Cys 
65                  70                  75      


<210>  39971
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplast transit peptide

<400>  39971

Met Ala Gln Ile Asn Asn Met Ala Gln Gly Ile Gln Thr Leu Asn Pro 
1               5                   10                  15      


Asn Ser Asn Phe His Lys Pro Gln Val Pro Lys Ser Ser Ser Phe Leu 
            20                  25                  30          


Val Phe Gly Ser Lys Lys Leu Lys Asn Ser Ala Asn Ser Met Leu Val 
        35                  40                  45              


Leu Lys Lys Asp Ser Ile Phe Met Gln Leu Phe Cys Ser Phe Arg Ile 
    50                  55                  60                  


Ser Ala Ser Val Ala Thr Ala Cys 
65                  70          


<210>  39972
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplast transit peptide

<400>  39972

Met Ala Ala Leu Val Thr Ser Gln Leu Ala Thr Ser Gly Thr Val Leu 
1               5                   10                  15      


Ser Val Thr Asp Arg Phe Arg Arg Pro Gly Phe Gln Gly Leu Arg Pro 
            20                  25                  30          


Arg Asn Pro Ala Asp Ala Ala Leu Gly Met Arg Thr Val Gly Ala Ser 
        35                  40                  45              


Ala Ala Pro Lys Gln Ser Arg Lys Pro His Arg Phe Asp Arg Arg Cys 
    50                  55                  60                  


Leu Ser Met Val Val 
65                  


<210>  39973
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplast transit peptide

<400>  39973

Met Ala Ala Leu Thr Thr Ser Gln Leu Ala Thr Ser Ala Thr Gly Phe 
1               5                   10                  15      


Gly Ile Ala Asp Arg Ser Ala Pro Ser Ser Leu Leu Arg His Gly Phe 
            20                  25                  30          


Gln Gly Leu Lys Pro Arg Ser Pro Ala Gly Gly Asp Ala Thr Ser Leu 
        35                  40                  45              


Ser Val Thr Thr Ser Ala Arg Ala Thr Pro Lys Gln Gln Arg Ser Val 
    50                  55                  60                  


Gln Arg Gly Ser Arg Arg Phe Pro Ser Val Val Val Cys 
65                  70                  75          


<210>  39974
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplast transit peptide

<400>  39974

Met Ala Ser Ser Val Leu Ser Ser Ala Ala Val Ala Thr Arg Ser Asn 
1               5                   10                  15      


Val Ala Gln Ala Asn Met Val Ala Pro Phe Thr Gly Leu Lys Ser Ala 
            20                  25                  30          


Ala Ser Phe Pro Val Ser Arg Lys Gln Asn Leu Asp Ile Thr Ser Ile 
        35                  40                  45              


Ala Ser Asn Gly Gly Arg Val Gln Cys 
    50                  55          


<210>  39975
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplast transit peptide

<400>  39975

Met Glu Ser Leu Ala Ala Thr Ser Val Phe Ala Pro Ser Arg Val Ala 
1               5                   10                  15      


Val Pro Ala Ala Arg Ala Leu Val Arg Ala Gly Thr Val Val Pro Thr 
            20                  25                  30          


Arg Arg Thr Ser Ser Thr Ser Gly Thr Ser Gly Val Lys Cys Ser Ala 
        35                  40                  45              


Ala Val Thr Pro Gln Ala Ser Pro Val Ile Ser Arg Ser Ala Ala Ala 
    50                  55                  60                  


Ala 
65  


<210>  39976
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplast transit peptide

<400>  39976

Met Gly Ala Ala Ala Thr Ser Met Gln Ser Leu Lys Phe Ser Asn Arg 
1               5                   10                  15      


Leu Val Pro Pro Ser Arg Arg Leu Ser Pro Val Pro Asn Asn Val Thr 
            20                  25                  30          


Cys Asn Asn Leu Pro Lys Ser Ala Ala Pro Val Arg Thr Val Lys Cys 
        35                  40                  45              


Cys Ala Ser Ser Trp Asn Ser Thr Ile Asn Gly Ala Ala Ala Thr Thr 
    50                  55                  60                  


Asn Gly Ala Ser Ala Ala Ser Ser 
65                  70          


<210>  39977
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endosomal escape peptide


<220>
<221>  SITE
<222>  (4)..(4)
<223>  Xaa is Lys, His or Arg

<220>
<221>  SITE
<222>  (8)..(8)
<223>  Xaa is Lys, His or Arg

<220>
<221>  SITE
<222>  (11)..(11)
<223>  Xaa is Lys, His or Arg

<220>
<221>  SITE
<222>  (15)..(15)
<223>  Xaa is Lys, His or Arg

<220>
<221>  SITE
<222>  (19)..(19)
<223>  Xaa is Lys, His or Arg

<400>  39977

Gly Leu Phe Xaa Ala Leu Leu Xaa Leu Leu Xaa Ser Leu Trp Xaa Leu 
1               5                   10                  15      


Leu Leu Xaa Ala 
            20  


<210>  39978
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endosomal escape peptide

<400>  39978

Gly Leu Phe His Ala Leu Leu His Leu Leu His Ser Leu Trp His Leu 
1               5                   10                  15      


Leu Leu His Ala 
            20  


<210>  39979
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endosomal escape peptide

<400>  39979

His His His His His His His His His 
1               5                   


<210>  39980
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplast transit peptide

<400>  39980

Met Ala Ser Met Ile Ser Ser Ser Ala Val Thr Thr Val Ser Arg Ala 
1               5                   10                  15      


Ser Arg Gly Gln Ser Ala Ala Met Ala Pro Phe Gly Gly Leu Lys Ser 
            20                  25                  30          


Met Thr Gly Phe Pro Val Arg Lys Val Asn Thr Asp Ile Thr Ser Ile 
        35                  40                  45              


Thr Ser Asn Gly Gly Arg Val Lys Ser 
    50                  55          


<210>  39981
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  39981
acuggcacuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  39982
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  39982
acuggcacuu cuaucugauu acucugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucagag                                97


<210>  39983
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  39983
acuggcgcuu cuaucugauu acucugagag ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  39984
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  39984
acuggcacuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  39985
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  39985
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  39986
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  39986
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guauggguaa       60

agcgccuuac ggacuucggu ccguaaggag caucagag                               98


<210>  39987
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  39987
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cggacuucgg uccguaagag gcaucagag                              99


<210>  39988
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  39988
acgggacuuu cuaucugauu acucugaagu cccucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  39989
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  39989
accuguaguu cuaucugauu acucugacua cagucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  39990
<211>  113
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  39990
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gugggcgcag cuucggcuga cgguacaccg ugcagcauca aag             113


<210>  39991
<211>  143
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  39991
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gugggcgcag cuucggcuga cgguacaccg gugggcgcag cuucggcuga      120

cgguacaccg ugcagcauca aag                                              143


<210>  39992
<211>  173
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  39992
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gugggcgcag cuucggcuga cgguacaccg gugggcgcag cuucggcuga      120

cgguacaccg gugggcgcag cuucggcuga cgguacaccg ugcagcauca aag             173


<210>  39993
<211>  203
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  39993
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gugggcgcag cuucggcuga cgguacaccg gugggcgcag cuucggcuga      120

cgguacaccg gugggcgcag cuucggcuga cgguacaccg gugggcgcag cuucggcuga      180

cgguacaccg ugcagcauca aag                                              203


<210>  39994
<211>  233
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  39994
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gugggcgcag cuucggcuga cgguacaccg gugggcgcag cuucggcuga      120

cgguacaccg gugggcgcag cuucggcuga cgguacaccg gugggcgcag cuucggcuga      180

cgguacaccg gugggcgcag cuucggcuga cgguacaccg ugcagcauca aag             233


<210>  39995
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  39995
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacc uagcggaggc uaggugcagc aucaaag                                97


<210>  39996
<211>  118
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  39996
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacc ucggcuugcu gaagcgcgca cggcaagagg cgaggugcag caucaaag        118


<210>  39997
<211>  192
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  39997
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacc ucucucgacg caggacucgg cuugcugaag cgcgcacggc aagaggcgag      120

gggcggcgac uggugaguac gccaaaaauu uugacuagcg gaggcuagaa ggagagaggu      180

gcagcaucaa ag                                                          192


<210>  39998
<211>  156
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  39998
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gugcccgucu guugugucga gagacgccaa aaauuuugac uagcggaggc      120

uagaaggaga gagaugggug ccgugcagca ucaaag                                156


<210>  39999
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  39999
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcaca uggagaggag augugcagca ucaaag                                 96


<210>  40000
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40000
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcaca uggagaugug cagcaucaaa g                                      91


<210>  40001
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40001
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcuugggc gcagcgucaa ugacgcugac gguacaagca ucaaag                     106


<210>  40002
<211>  145
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40002
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgucaaugac gcugacggua caggccacau gaggaucacc      120

caugugguau agugcagcau caaag                                            145


<210>  40003
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40003
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cucaugagga ucacccauga gcugacggua caggccacau      120

gaggaucacc caugugguau agugcagcau caaag                                 155


<210>  40004
<211>  151
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40004
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgucaaugac gcugacggua caggccacau ggcagucgua      120

acgacgcggg ugguauagug cagcaucaaa g                                     151


<210>  40005
<211>  172
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40005
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag caaacauggc aguccuaagg acgcggguuu ugcugacggu      120

acaggccaca uggcagucgu aacgacgcgg gugguauagu gcagcaucaa ag              172


<210>  40006
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40006
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag acauggcagu cguaacgacg cgggucugac gguacaggcc      120

acaugaggau cacccaugug guauagugca gcaucaaag                             159


<210>  40007
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40007
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu aaggaguuua uauggaaacc cuuagugcag caucaaag                   108


<210>  40008
<211>  242
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40008
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucagga agcacuaugg gcgcagcguc aaugacgcug acgguacagg ccagacaauu      120

auugucuggu auagugcagc agcagaacaa uuugcugagg gcuauugagg cgcaacagca      180

ucuguugcaa cucacagucu ggggcaucaa gcagcuccag gcaagaaucc ugagcaucaa      240

ag                                                                     242


<210>  40009
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40009
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg cccugaagaa gggcgugcag caucaaag                               98


<210>  40010
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40010
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gcucguguag cucauuagcu ccgagccgug cagcaucaaa g               111


<210>  40011
<211>  113
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40011
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacc cgugugcauc cgcagugucg gauccacggg ugcagcauca aag             113


<210>  40012
<211>  112
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40012
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacg gaauccauug cacuccggau uucacuaggu gcagcaucaa ag              112


<210>  40013
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40013
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcaca ugcaugucua agacagcaug ugcagcauca aag                        103


<210>  40014
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40014
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcaca aaacauaagg aaaaccuaug uugugcagca ucaaag                     106


<210>  40015
<211>  153
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40015
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cggacuaugg gcgcagcguc aaugacgcug acgguacagg ccagacaauu      120

auugucuggu auaguccgua agaggcauca gag                                   153


<210>  40016
<211>  147
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40016
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cgggugggcg cagcgucaau gacgcugacg guacaggcca gacaauuauu      120

gucugguacc cguaagaggc aucagag                                          147


<210>  40017
<211>  153
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40017
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cgguaugggc gcagcgucaa ugacgcugac gguacaggcc acaugaggau      120

cacccaugug guauaccgua agaggcauca gag                                   153


<210>  40018
<211>  143
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40018
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccua ugggcgcagc gucaaugacg cugacgguac aggccacaug aggaucaccc      120

augugguaua gggagcauca aag                                              143


<210>  40019
<211>  163
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40019
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cgguaugggc gcagcucaug aggaucaccc augagcugac gguacaggcc      120

acaugaggau cacccaugug guauaccgua agaggcauca gag                        163


<210>  40020
<211>  153
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40020
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccua ugggcgcagc ucaugaggau cacccaugag cugacgguac aggccacaug      120

aggaucaccc augugguaua gggagcauca aag                                   153


<210>  40021
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40021
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cgguaugggc gcagcgucaa ugacgcugac gguacaggcc acauggcagu      120

cguaacgacg cgggugguau accguaagag gcaucagag                             159


<210>  40022
<211>  149
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40022
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccua ugggcgcagc gucaaugacg cugacgguac aggccacaug gcagucguaa      120

cgacgcgggu gguauaggga gcaucaaag                                        149


<210>  40023
<211>  180
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40023
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cgguaugggc gcagcaaaca uggcaguccu aaggacgcgg guuuugcuga      120

cgguacaggc cacauggcag ucguaacgac gcggguggua uaccguaaga ggcaucagag      180


<210>  40024
<211>  170
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40024
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccua ugggcgcagc aaacauggca guccuaagga cgcggguuuu gcugacggua      120

caggccacau ggcagucgua acgacgcggg ugguauaggg agcaucaaag                 170


<210>  40025
<211>  167
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40025
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagccgcuua cgguaugggc gcagacaugg cagucguaac gacgcggguc ugacgguaca      120

ggccacauga ggaucaccca ugugguauac cguaagaggc aucagag                    167


<210>  40026
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  40026
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccua ugggcgcaga cauggcaguc guaacgacgc gggucugacg guacaggcca      120

caugaggauc acccaugugg uauagggagc aucaaag                               157


<210>  40027
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40027

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40028
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40028

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40029
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40029

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40030
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40030

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40031
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40031

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Thr Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40032
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40032

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ala Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40033
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40033

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Val Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40034
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40034

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Leu Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40035
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40035

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asn Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40036
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40036

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gln Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40037
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40037

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Ser Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40038
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40038

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Ala Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40039
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40039

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40040
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40040

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Thr Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40041
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40041

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Arg Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40042
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40042

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu His 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40043
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40043

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Glu Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40044
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40044

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Ile Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40045
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40045

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Phe Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40046
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40046

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Trp Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40047
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40047

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Asp Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40048
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40048

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Thr Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40049
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40049

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Asp Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40050
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40050

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Pro Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40051
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40051

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Lys Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40052
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40052

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Lys Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40053
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40053

Gln Glu Gly Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40054
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40054

Gln Glu Glu Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40055
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40055

Gln Glu Ile Gly Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40056
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40056

Gln Glu Ile Gly Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40057
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40057

Gln Glu Ile Ser Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40058
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40058

Gln Glu Ile Lys Gly Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40059
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40059

Gln Glu Ile Lys Ser Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40060
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40060

Gln Glu Ile Lys Arg Ala Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40061
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40061

Gln Glu Ile Lys Arg Gly Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40062
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40062

Gln Glu Ile Lys Arg Ile Ser Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40063
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40063

Gln Glu Ile Lys Arg Ile Asn Gly Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40064
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40064

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Phe 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40065
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40065

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Phe Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40066
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40066

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Pro Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40067
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40067

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Pro Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40068
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40068

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40069
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40069

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Pro Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40070
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40070

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Ser Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40071
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40071

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Gln Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40072
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40072

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Thr His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40073
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40073

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Gly Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40074
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40074

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Asp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40075
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40075

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Ala Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40076
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40076

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Arg Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40077
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40077

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40078
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40078

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Tyr Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40079
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40079

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ser Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40080
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40080

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Pro Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40081
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40081

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40082
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40082

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40083
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40083

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Gly 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40084
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40084

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Ser 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40085
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40085

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Leu Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40086
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40086

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Thr Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40087
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40087

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Trp Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40088
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40088

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Asn Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40089
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40089

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Gln Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40090
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40090

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Ala Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40091
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40091

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40092
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40092

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Pro 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40093
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40093

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40094
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40094

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Leu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40095
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40095

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Arg 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40096
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40096

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40097
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40097

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn His Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40098
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40098

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Ala Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40099
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40099

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40100
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40100

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Pro Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40101
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40101

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Thr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40102
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40102

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Met 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40103
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40103

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Asn His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40104
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40104

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Trp His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40105
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40105

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Tyr Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40106
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40106

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Pro Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40107
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40107

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Glu Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40108
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40108

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Arg Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40109
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40109

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Trp Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40110
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40110

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Tyr Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40111
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40111

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Tyr Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40112
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40112

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Arg Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40113
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40113

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Asp 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40114
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40114

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Pro 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40115
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40115

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Leu Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40116
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40116

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Gly Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40117
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40117

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Gln Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40118
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40118

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Asp Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40119
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40119

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Thr Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40120
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40120

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Thr Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40121
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40121

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Lys Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40122
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40122

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Glu Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40123
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40123

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Ser Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40124
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40124

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Arg Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40125
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40125

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Lys Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40126
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40126

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Ser Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40127
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40127

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40128
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40128

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Gln Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40129
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40129

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Lys Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40130
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40130

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Asp Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40131
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40131

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Val 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40132
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40132

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Asp 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40133
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40133

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Arg Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40134
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40134

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys His Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40135
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40135

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Pro Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40136
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40136

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Thr Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40137
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40137

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Phe 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40138
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40138

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Val 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40139
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40139

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40140
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40140

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Thr Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40141
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40141

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Asn Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40142
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40142

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Arg Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40143
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40143

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Ser Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40144
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40144

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Trp Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40145
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40145

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Arg Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40146
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40146

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ser Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40147
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40147

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val His 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40148
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40148

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Ser Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40149
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40149

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Ala Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40150
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40150

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Asp Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40151
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40151

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Asn Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40152
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40152

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Val Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40153
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40153

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Ile Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40154
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40154

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40155
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40155

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40156
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40156

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40157
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40157

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40158
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40158

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40159
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40159

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Asp Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40160
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40160

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys His Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40161
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40161

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40162
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40162

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40163
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40163

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40164
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40164

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40165
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40165

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40166
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40166

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40167
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40167

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40168
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40168

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40169
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40169

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40170
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40170

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40171
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40171

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40172
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40172

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40173
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40173

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40174
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40174

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40175
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40175

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40176
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40176

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40177
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40177

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40178
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40178

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40179
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40179

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40180
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40180

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40181
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40181

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40182
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40182

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40183
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40183

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40184
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40184

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40185
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40185

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40186
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40186

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40187
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40187

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40188
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  40188

Pro Ala Lys Arg Ala Arg Arg Gly Tyr Lys Cys 
1               5                   10      


<210>  40189
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  40189

Lys Leu Gly Pro Arg Lys Ala Thr Gly Arg Trp 
1               5                   10      


<210>  40190
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  40190

Pro Arg Arg Lys Arg Glu Glu 
1               5           


<210>  40191
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  40191

Pro Tyr Arg Gly Arg Lys Glu 
1               5           


<210>  40192
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  40192

Pro Leu Arg Lys Arg Pro Arg Arg 
1               5               


<210>  40193
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  40193

Pro Leu Arg Lys Arg Pro Arg Arg Gly Ser Pro Leu Arg Lys Arg Pro 
1               5                   10                  15      


Arg Arg 
        


<210>  40194
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  40194

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Lys Arg Thr Ala Asp 
1               5                   10                  15      


Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg Lys Val 
            20                  25                  


<210>  40195
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  40195

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Lys Arg Thr Ala Asp 
1               5                   10                  15      


Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg Lys Val Gly Ile His 
            20                  25                  30          


Gly Val Pro Ala Ala 
        35          


<210>  40196
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  40196

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Lys Arg Thr Ala Asp 
1               5                   10                  15      


Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg Lys Val Ala Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
        35                  40                  45      


<210>  40197
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  40197

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Lys Arg Thr Ala Asp 
1               5                   10                  15      


Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg Lys Val Pro Gly 
            20                  25                  30      


<210>  40198
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  40198

Lys Arg Lys Gly Ser Pro Glu Arg Gly Glu Arg Lys Arg His Trp 
1               5                   10                  15  


<210>  40199
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  40199

Lys Arg Thr Ala Asp Ser Gln His Ser Thr Pro Pro Lys Thr Lys Arg 
1               5                   10                  15      


Lys Val Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
            20                  25              


<210>  40200
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  40200

Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Lys Arg Thr Ala Asp Ser 
1               5                   10                  15      


Gln His Ser Thr Pro Pro Lys Thr Lys Arg Lys Val Glu Phe Glu Pro 
            20                  25                  30          


Lys Lys Lys Arg Lys Val 
        35              


<210>  40201
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  SITE
<222>  (2)..(5)
<223>  individual amino acid residues may be present or absent

<400>  40201

Gly Gly Gly Gly Gly 
1               5   


<210>  40202
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  SITE
<222>  (3)..(4)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (5)..(6)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (7)..(8)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (9)..(10)
<223>  grouped amino acid residues may be present or absent

<400>  40202

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10  


<210>  40203
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  SITE
<222>  (8)..(11)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (12)..(15)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (16)..(19)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (20)..(23)
<223>  grouped amino acid residues may be present or absent

<400>  40203

Pro Pro Pro Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Ser 
            20              


<210>  40204
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  SITE
<222>  (1)..(4)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (5)..(8)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (9)..(12)
<223>  grouped amino acid residues may be present or absent

<220>
<221>  SITE
<222>  (13)..(16)
<223>  grouped amino acid residues may be present or absent

<400>  40204

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Pro Pro Pro 
            20              


<210>  40205
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  40205

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Ala 
    


<210>  40206
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  40206

Thr Pro Pro Lys Thr Lys Arg Lys Val Glu Phe Glu 
1               5                   10          


<210>  40207
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  40207

Pro Pro Pro Gly 
1               


<210>  40208
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40208

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40209
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40209

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40210
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40210

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40211
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40211

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40212
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40212

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Thr Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40213
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40213

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ala Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40214
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40214

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Val Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40215
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40215

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Leu Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40216
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40216

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asn Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40217
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40217

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gln Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40218
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40218

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Ser Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40219
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40219

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Ala Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40220
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40220

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40221
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40221

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Thr Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40222
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40222

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Arg Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40223
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40223

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu His 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40224
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40224

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Glu Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40225
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40225

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Ile Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40226
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40226

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Phe Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40227
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40227

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Trp Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40228
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40228

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Asp Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40229
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40229

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Thr Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40230
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40230

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Asp Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40231
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40231

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Pro Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40232
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40232

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Lys Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40233
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40233

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Lys Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40234
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40234

Gln Glu Gly Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40235
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40235

Gln Glu Glu Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40236
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40236

Gln Glu Ile Gly Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40237
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40237

Gln Glu Ile Gly Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40238
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40238

Gln Glu Ile Ser Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40239
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40239

Gln Glu Ile Lys Gly Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40240
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40240

Gln Glu Ile Lys Ser Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40241
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40241

Gln Glu Ile Lys Arg Ala Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40242
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40242

Gln Glu Ile Lys Arg Gly Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40243
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40243

Gln Glu Ile Lys Arg Ile Ser Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40244
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40244

Gln Glu Ile Lys Arg Ile Asn Gly Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40245
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40245

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Phe 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40246
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40246

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Phe 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40247
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40247

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Phe Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40248
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40248

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Pro Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40249
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40249

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Pro Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40250
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40250

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40251
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40251

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Pro Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40252
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40252

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Ser Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40253
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40253

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Gln Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40254
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40254

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Thr His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40255
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40255

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Gly Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40256
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40256

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Asp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40257
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40257

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Ala Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40258
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40258

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Arg Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40259
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40259

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40260
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40260

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Tyr Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40261
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40261

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ser Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40262
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40262

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Pro Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40263
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40263

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40264
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40264

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40265
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40265

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Gly 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40266
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40266

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Ser 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40267
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40267

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Leu Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40268
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40268

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Thr Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40269
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40269

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Trp Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40270
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40270

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Asn Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40271
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40271

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Gln Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40272
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40272

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Ala Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40273
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40273

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40274
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40274

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Pro 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40275
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40275

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40276
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40276

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Leu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40277
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40277

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Arg 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40278
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40278

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40279
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40279

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn His Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40280
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40280

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Ala Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40281
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40281

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40282
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40282

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Pro Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40283
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40283

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Thr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40284
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40284

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Met 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40285
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40285

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Asn His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40286
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40286

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Trp His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40287
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40287

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Tyr Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40288
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40288

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Pro Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40289
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40289

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Glu Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40290
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40290

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Arg Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40291
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40291

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Trp Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40292
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40292

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Tyr Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40293
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40293

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Tyr Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40294
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40294

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Arg Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40295
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40295

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Asp 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40296
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40296

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Pro 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40297
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40297

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Leu Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40298
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40298

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Gly Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40299
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40299

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Gln Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40300
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40300

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Asp Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40301
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40301

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Thr Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40302
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40302

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Thr Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40303
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40303

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Lys Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40304
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40304

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Glu Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40305
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40305

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Ser Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40306
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40306

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Arg Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40307
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40307

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Lys Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40308
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40308

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Ser Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40309
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40309

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40310
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40310

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Gln Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40311
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40311

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Lys Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40312
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40312

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Asp Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40313
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40313

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Val 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40314
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40314

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Asp 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40315
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40315

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Arg Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40316
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40316

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys His Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40317
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40317

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Pro Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40318
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40318

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Thr Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40319
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40319

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Phe 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40320
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40320

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Val 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40321
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40321

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40322
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40322

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Thr Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40323
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40323

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Asn Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40324
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40324

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Arg Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40325
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40325

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Ser Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40326
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40326

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Trp Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40327
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40327

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Arg Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40328
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40328

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ser Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40329
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40329

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val His 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40330
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40330

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Ser Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40331
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40331

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Ala Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40332
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40332

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Asp Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40333
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40333

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Asn Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40334
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40334

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Val Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40335
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40335

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Ile Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40336
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40336

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40337
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40337

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40338
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40338

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40339
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40339

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40340
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40340

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40341
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40341

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Asp Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40342
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40342

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys His Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40343
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40343

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40344
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40344

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40345
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40345

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40346
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40346

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40347
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40347

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40348
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40348

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40349
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40349

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40350
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40350

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40351
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40351

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40352
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40352

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40353
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40353

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40354
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40354

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40355
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40355

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40356
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40356

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40357
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40357

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40358
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40358

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40359
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40359

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40360
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40360

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40361
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40361

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40362
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40362

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40363
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40363

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40364
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40364

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40365
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40365

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40366
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40366

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40367
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40367

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40368
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40368

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40369
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40369

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser His Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Gly Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40370
<211>  584
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40370
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      540

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agct                       584


<210>  40371
<211>  400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40371
ggcctccgcg ccgggttttg gcgcctcccg cgggcgcccc cctcctcacg gcgagcgctg       60

ccacgtcaga cgaagggcgc agcgagcgtc ctgatccttc cgcccggacg ctcaggacag      120

cggcccgctg ctcataagac tcggccttag aaccccagta tcagcagaag gacattttag      180

gacgggactt gggtgactct agggcactgg ttttctttcc agagagcgga acaggcgagg      240

aaaagtagtc ccttctcggc gattctgcgg agggatctcc gtggggcggt gaacgccgat      300

gattatataa ggacgcgccg ggtgtggcac agctagttcc gtcgcagccg ggatttgggt      360

cgcggttctt gtttgtggat cgctgtgatc gtcacttggt                            400


<210>  40372
<211>  234
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40372
tggctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg agaagttggg       60

gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa actgggaaag      120

tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt atataagtgc      180

agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac aggt            234


<210>  40373
<211>  335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40373
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catgagaggg tatataatgg aagctcgact tccag                                 335


<210>  40374
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40374
ccaaaatcaa cgggactttc caaaatgtcg taataacccc gccccgttga cgcaaatggg       60

cggtaggcgt gtacggtggg aggtctatat aagcagagct                            100


<210>  40375
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40375
gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag ct               52


<210>  40376
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40376
ggtaggcgtg tacggtggga ggtctatata agcagagct                              39


<210>  40377
<211>  146
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40377
atgacacaaa ccccgcccag cgtcttgtca ttggcgaatt cgaacacgca gatgcagtcg       60

gggcggcgcg gtcccaggtc cacttcgcat attaaggtga cgcgtgtggc ctcgaacacc      120

gagcgaccct gcagcgaccc gcttaa                                           146


<210>  40378
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40378
ttcgcatatt aaggtgacgc gtgtggcctc gaacaccgag cgaccctgca gcgacccgct       60

taa                                                                     63


<210>  40379
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40379
cattttgaca cccccataat atttttccag aattaacagt ataaattgca tctcttgttc       60

aagagttccc tatcactctc tttaatcact actcacagta acctcaactc ctgc            114


<210>  40380
<211>  703
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40380
actagtttca tcaccaccgc cacccccccg cccccccgcc atctgaaagg gttctagggg       60

atttgcaacc tctctcgtgt gtttcttctt tccgagaagc gccgccacac gagaaagctg      120

gccgcgaaag tcgtgctgga atcacttcca acgaaacccc aggcatagat gggaaagggt      180

gaagaacacg ttgccatggc taccgtttcc ccggtcacgg aataaacgct ctctaggatc      240

cggaagtagt tccgccgcga cctctctaaa aggatggatg tgttctctgc ttacattcat      300

tggacgtttt cccttagagg ccaaggccgc ccaggcaaag gggcggtccc acgcgtgagg      360

ggcccgcgga gccatttgat tggagaaaag ctgcaaaccc tgaccaatcg gaaggagcca      420

cgcttcgggc atcggtcacc gcacctggac agctccgatt ggtggacttc cgccccccct      480

cacgaatcct cattgggtgc cgtgggtgcg tggtgcggcg cgattggtgg gttcatgttt      540

cccgtccccc gcccgcgaga agtgggggtg aaaagcggcc cgacctgctt ggggtgtagt      600

gggcggaccg cgcggctgga ggtgtgagga tccgaaccca ggggtggggg gtggaggcgg      660

ctcctgcgat cgaaggggac ttgagactca ccggccgcac gtc                        703


<210>  40381
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40381
gtacttatat aagggggtgg gggcgcgttc gtcctcagtc gcgatcgaac actcgagccg       60

agcagacgtg cctacggacc g                                                 81


<210>  40382
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40382
aggtctatat aagcagagct cgtttagtga accgtcagat cgcctggaga cgtcgagccg       60

agtggttgtg cctccataga a                                                 81


<210>  40383
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40383
aggtctatat aagcagagct cgtttagtga accgtcagtc cgcctggaga cctgcagccg       60

agtggtcgtg cctccataga a                                                 81


<210>  40384
<211>  229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40384
agctgaatgg ggtccgcctc ttttccctgc ctaaacagac aggaactcct gccaattgag       60

ggcgtcaccg ctaaggctcc gccccagcct gggctccaca accaatgaag ggtaatctcg      120

acaaagagca aggggtgggg cgcgggcgcg caggtgcagc agcacacagg ctggtcggga      180

gggcggggcg cgacgtctgc cgtgcggggt cccggcatcg gttgcgcgc                  229


<210>  40385
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40385
ggtaggcgtg tacggtggga ggcctatata agcagagctc gtttagtgaa ccgtcagatc       60

gcctggag                                                                68


<210>  40386
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40386
aggtctatat aagcagagct ctctggctaa ctagagaacc cactgcttaa ctggcttatc       60

gaaat                                                                   65


<210>  40387
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40387
ggtaggcgtg tacggtggga ggtctatata agcagagct                              39


<210>  40388
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40388
ggggctataa aagggggtgg gggcgcgttc gtcctcactc tcttccgcat cgctgtctgc       60

gagggccagc tgttggggtg a                                                 81


<210>  40389
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40389
gggggaggag attaggttaa aggtctttgt attaggaggc tgtaggcata aattggtctg       60

ttcaccagca ccatgcaact ttttcacctc tgcctaatca tctcatg                    107


<210>  40390
<211>  227
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40390
tgtagtctta tgcaatactc ttgtagtctt gcaacatggt aacgatgagt tagcaacatg       60

ccttacaagg agagaaaaag caccgtgcat gccgattggt ggaagtaagg tggtacgatc      120

gtgccttatt aggaaggcaa cagacgggtc tgacatggat tggacgaacc actgaattgc      180

cgcattgcag agatattgta tttaagtgcc tagctcgata cataaac                    227


<210>  40391
<211>  448
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40391
agtgcaagtg ggttttagga ccaggatgag gcggggtggg ggtgcctacc tgacgaccga       60

ccccgaccca ctggacaagc acccaacccc cattccccaa attgcgcatc ccctatcaga      120

gagggggagg ggaaacagga tgcggcgagg cgcgtgcgca ctgccagctt cagcaccgcg      180

gacagtgcct tcgcccccgc ctggcggcgc gcgccaccgc cgcctcagca ctgaaggcgc      240

gctgacgtca ctcgccggtc ccccgcaaac tccccttccc ggccaccttg gtcgcgtccg      300

cgccgccgcc ggcccagccg gaccgcacca cgcgaggcgc gagatagggg ggcacgggcg      360

cgaccatctg cgctgcggcg ccggcgactc agcgctgcct cagtctgcgg tgggcagcgg      420

aggagtcgtg tcgtgcctga gagcgcag                                         448


<210>  40392
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40392
gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc       60

atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga      120

agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc      180

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt      240

tttatttatg cagaggccga ggccgcctcg gcctctgagc tattccagaa gtagtgagga      300

ggcttttttg gaggcctagg cttttgcaaa                                       330


<210>  40393
<211>  511
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40393
ggggttgggg ttgcgccttt tccaaggcag ccctgggttt gcgcagggac gcggctgctc       60

tgggcgtggt tccgggaaac gcagcggcgc cgaccctggg tctcgcacat tcttcacgtc      120

cgttcgcagc gtcacccgga tcttcgccgc tacccttgtg ggccccccgg cgacgcttcc      180

tgctccgccc ctaagtcggg aaggttcctt gcggttcgcg gcgtgccgga cgtgacaaac      240

ggaagccgca cgtctcacta gtaccctcgc agacggacag cgccagggag caatggcagc      300

gcgccgaccg cgatgggctg tggccaatag cggctgctca gcagggcgcg ccgagagcag      360

cggccgggaa ggggcggtgc gggaggcggg gtgtggggcg gtagtgtggg ccctgttcct      420

gcccgcgcgg tgttccgcat tctgcaagcc tccggagcgc acgtcggcag tcggctccct      480

cgttgaccga atcaccgacc tctctcccca g                                     511


<210>  40394
<211>  164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40394
gggcggagtt agggcggagc caatcagcgt gcgccgttcc gaaagttgcc ttttatggct       60

gggcggagaa tgggcggtga acgccgatga ttatataagg acgcgccggg tgtggcacag      120

ctagttccgt cgcagccggg atttgggtcg cggttcttgt ttgt                       164


<210>  40395
<211>  326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40395
gggcggagtt agggcggagc caatcagcgt gcgccgttcc gaaagttgcc ttttatggct       60

gggcggagaa tgggcggtga acgccgatga ttatataagg acgcgccggg tgtggcacag      120

ctagttccgt cgcagccggg atttgggtcg cggttcttgt ttgtggatcc ctgtgatcgt      180

cacttggtaa gtcactgact gtctatgcct gggaaagggt gggcaggaga tggggcagtg      240

caggaaaagt ggcactatga accctgcagc cctaggaatg catctagaca attgtactaa      300

ccttcttctc tttcctctcc tgacag                                           326


<210>  40396
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40396
ccccgcagcc attctagcta gcggtaccaa tagcaaccgg cagctgccct ccgcttttgc       60

tccgcccctt ctgcttgcga tctgtttccg cttccggtcc cgcagttccg gctctgccgt      120

gaagagcttt gcattgtggg aagtctttcc tttctcgttc cccggccatc ttagcggctg      180

ctgttggtga gtgggctcct accgaccgag gtttaggcag cgcggggagc tttgcgggtt      240

gccatttgta actccggatc ctaaaattcc tgtcctgttc tctgtctctt ctaggttggg      300

ggccgtcccg ctcctaaggc aggaa                                            325


<210>  40397
<211>  243
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40397
agccccggaa ccttcgctgt tctcttacct atgaacctta cgaactgtaa agaaaggcgc       60

accggaagtt gtggtaccca agccatactc tcataaatcc agccaggtcg cgctgaaaca      120

gtttccggaa gcacttctcc tagatcgcac cgcctcttcc tcctggaagc tatataatga      180

tatcgcgtca cttccgctct ctcttccaca ggaggcctac acgccgccgc ttgtgctgca      240

gcc                                                                    243


<210>  40398
<211>  493
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40398
ccacgttctg cttcactctc cccatctccc ccccctcccc acccccaatt ttgtatttat       60

ttatttttta attattttgt gcagcgatgg gggcgggggg gggggggggg cgcgcgccag      120

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      180

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      240

ataaaaagcg aagcgcgcgg cgggcgggag cgggatcagc caccgcggtg gcggcctaga      300

gtcgacgagg aactgaaaaa ccagaaagtt aactggtaag tttagtcttt ttgtctttta      360

tttcaggtcc cggatccggt ggtggtgcaa atcaaagaac tgctcctcag tggatgttgc      420

ctttacttct aggcctgtac ggaagtgtta cttctgctct aaaagctgcg gaattgtacc      480

cgcggccgat cca                                                         493


<210>  40399
<211>  565
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40399
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg      120

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga      180

cgtcaatgac ggtaaatggc ccgcctggca ttgtgcccag tacatgacct tatgggactt      240

tcctacttgg cagtacatct acgtattagt catcgctatt accatggtcg aggtgagccc      300

cacgttctgc ttcactctcc ccatctcccc cccctcccca cccccaattt tgtatttatt      360

tattttttaa ttattttgtg cagcgatggg ggcggggggg gggggggggc gcgcgccagg      420

cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa      480

tcagagcggc gcgctccgaa agtttccttt tatggcgagg cggcggcggc ggcggcccta      540

taaaaagcga agcgcgcggc gggcg                                            565


<210>  40400
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  40400
gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      180

tgggaggtct atataagcag agct                                             204


<210>  40401
<211>  241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  40401
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

c                                                                      241


<210>  40402
<211>  215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  40402
gaacgctgac gtcatcaacc cgctccaagg aatcgcgggc ccagtgtcac taggcgggaa       60

cacccagcgc gcgtgcgccc tggcaggaag atggctgtga gggacagggg agtggcgccc      120

tgcaatattt gcatgtcgct atgtgttctg ggaaatcacc ataaacgtga aatgtctttg      180

gatttgggaa tcttataagt tctgtatgag accac                                 215


<210>  40403
<211>  244
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  40403
ctgcagtatt tagcatgccc cacccatctg caaggcattc tggatagtgt caaaacagcc       60

ggaaatcaag tccgtttatc tcaaacttta gcattttggg aataaatgat atttgctatg      120

ctggttaaat tagattttag ttaaatttcc tgctgaagct ctagtacgat aagtaacttg      180

acctaagtgt aaagttgaga tttccttcag gtttatatag cttgtgcgcc gcctgggtac      240

ctcg                                                                   244


<210>  40404
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  40404
gagggcctat ttcccatgat tccttcatat ttgcatatac gatagcttac cgtaacttga       60

aagtatttcg atttcttggc tttatatatc ttgtggaaag gac                        103


<210>  40405
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  40405
tttcgatttc ttggctttat atatcttgtg gaaaggac                               38


<210>  40406
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  40406
atacgatagc ttaccgtaac ttgaaagtat ttcgatttct tggctttata tatcttgtgg       60

aaaggac                                                                 67


<210>  40407
<211>  79
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  40407
gagggcctat ttcccatgat tccttcatat ttgcattttc gatttcttgg ctttatatat       60

cttgtggaaa ggacgaaac                                                    79


<210>  40408
<211>  111
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  40408
gagggcctat ttcccatgat tccttcatat ttgcatattt gcatatacga tagcttaccg       60

taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga c               111


<210>  40409
<211>  127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  40409
gagggcctat ttcccatgat tccttcatat ttgcatattt gcatatttgc atatttgcat       60

atacgatagc ttaccgtaac ttgaaagtat ttcgatttct tggctttata tatcttgtgg      120

aaaggac                                                                127


<210>  40410
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  40410
gagggcctat ttcccatgat tccttcatat ttcccatgat tccttcatat ttgcatatac       60

gatagcttac cgtaacttga aagtatttcg atttcttggc tttatatatc ttgtggaaag      120

gac                                                                    123


<210>  40411
<211>  143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  40411
gagggcctat ttcccatgat tccttcatat ttcccatgat tccttcatat ttcccatgat       60

tccttcatat ttgcatatac gatagcttac cgtaacttga aagtatttcg atttcttggc      120

tttatatatc ttgtggaaag gac                                              143


<210>  40412
<211>  131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  40412
gagggcctat ttcccatgat tccttcatat ttgcatattt cccatgattc cttcatattt       60

gcatatacga tagcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt      120

gtggaaagga c                                                           131


<210>  40413
<211>  159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  40413
gagggcctat ttcccatgat tccttcatat ttgcatattt cccatgattc cttcatattt       60

gcatatttcc catgattcct tcatatttgc atatacgata gcttaccgta acttgaaagt      120

atttcgattt cttggcttta tatatcttgt ggaaaggac                             159


<210>  40414
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  40414
gagggcctat ttcccatgat tccttcatat gcaaatatac gatagcttac cgtaacttga       60

aagtatttcg atttcttggc tttatatatc ttgtggaaag gac                        103


<210>  40415
<211>  111
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  40415
gagggcctat ttcccatgat tccttcatat gcaaatatgc aaatatacga tagcttaccg       60

taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga c               111


<210>  40416
<211>  127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  40416
gagggcctat ttcccatgat tccttcatat gcaaatatgc aaatatgcaa atatgcaaat       60

atacgatagc ttaccgtaac ttgaaagtat ttcgatttct tggctttata tatcttgtgg      120

aaaggac                                                                127


<210>  40417
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  40417
gagggcctat gcaaatatga aggaatcatg ggaaatatac gatagcttac cgtaacttga       60

aagtatttcg atttcttggc tttatatatc ttgtggaaag gac                        103


<210>  40418
<211>  131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  40418
gagggcctat gcaaatatga aggaatcatg ggaaatatgc aaatatgaag gaatcatggg       60

aaatatacga tagcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt      120

gtggaaagga c                                                           131


<210>  40419
<211>  159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  40419
gagggcctat gcaaatatga aggaatcatg ggaaatatgc aaatatgaag gaatcatggg       60

aaatatgcaa atatgaagga atcatgggaa atatacgata gcttaccgta acttgaaagt      120

atttcgattt cttggcttta tatatcttgt ggaaaggac                             159


<210>  40420
<211>  128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  40420
gagggcctat ttcccatgat tccttcatat ttgcatatac gtttgactgt aaatacgtga       60

cgtagaatag cttaccgtaa cttgaaagta tttcgatttc ttggctttat atatcttgtg      120

gaaaggac                                                               128


<210>  40421
<211>  208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly A sequence

<400>  40421
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagagaa tagcaggcat gctgggga                                         208


<210>  40422
<211>  623
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly A sequence

<400>  40422
gggtggcatc cctgtgaccc ctccccagtg cctctcctgg ccctggaagt tgccactcca       60

gtgcccacca gccttgtcct aataaaatta agttgcatca ttttgtctga ctaggtgtcc      120

ttctataata ttatggggtg gaggggggtg gtatggagca aggggcaagt tgggaagaca      180

acctgtaggg cctgcggggt ctattgggaa ccaagctgga gtgcagtggc acaatcttgg      240

ctcactgcaa tctccgcctc ctgggttcaa gcgattctcc tgcctcagcc tcccgagttg      300

ttgggattcc aggcatgcat gaccaggctc agctaatttt tgtttttttg gtagagacgg      360

ggtttcacca tattggccag gctggtctcc aactcctaat ctcaggtgat ctacccacct      420

tggcctccca aattgctggg attacaggcg tgaaccactg ctcccttccc tgtccttctg      480

attttaaaat aactatacca gcaggaggac gtccagacac agcataggct acctggccat      540

gcccaaccgg tgggacattt gagttgcttg cttggcactg tcctctcatg cgttgggtcc      600

actcagtaga tgcctgttga att                                              623


<210>  40423
<211>  477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly A sequence

<400>  40423
gggtggcatc cctgtgaccc ctccccagtg cctctcctgg ccctggaagt tgccactcca       60

gtgcccacca gccttgtcct aataaaatta agttgcatca ttttgtctga ctaggtgtcc      120

ttctataata ttatggggtg gaggggggtg gtatggagca aggggcaagt tgggaagaca      180

acctgtaggg cctgcggggt ctattgggaa ccaagctgga gtgcagtggc acaatcttgg      240

ctcactgcaa tctccgcctc ctgggttcaa gcgattctcc tgcctcagcc tcccgagttg      300

ttgggattcc aggcatgcat gaccaggctc agctaatttt tgtttttttg gtagagacgg      360

ggtttcacca tattggccag gctggtctcc aactcctaat ctcaggtgat ctacccacct      420

tggcctccca aattgctggg attacaggcg tgaaccactg ctcccttccc tgtcctt         477


<210>  40424
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly A sequence

<400>  40424
cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttc                   49


<210>  40425
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly A sequence

<400>  40425
aataaaagat ctttattttc attagatctg tgtgttggtt ttttgtgtg                   49


<210>  40426
<211>  122
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly A sequence

<400>  40426
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct      120

ta                                                                     122


<210>  40427
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly A sequence

<400>  40427
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcact gc                                                82


<210>  40428
<211>  395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly A sequence

<400>  40428
gctcgctttc ttgctgtcca atttctatta aaggttcctt tgttccctaa gtccaactac       60

taaactgggg gatattatga agggccttga gcatctggat tctgcctaat aaaaaacatt      120

tattttcatt gcaatgatgt atttaaatta tttctgaata ttttactaaa aagggaatgt      180

gggaggtcag tgcatttaaa acataaagaa atgaagagct agttcaaacc ttgggaaaat      240

acactatatc ttaaactcca tgaaagaagg tgaggctgca aacagctaat gcacattggc      300

aacagcccct gatgcctatg ccttattcat ccctcagaaa aggattcaag tagaggcttg      360

atttggaggt taaagttttg ctatgctgta tttta                                 395


<210>  40429
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly A sequence

<400>  40429
aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt ctctca           56


<210>  40430
<211>  181
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly A sequence

<400>  40430
tatttgtgaa atttgtgatg ctattgcttt atttgtaacc atctagcttt atttgtgaaa       60

tttgtgatgc tattgcttta tttgtaacca ttataagctg caataaacaa gttaacaaca      120

acaattgcat tcattttatg tttcaggttc agggggagat gtgggaggtt ttttaaagcg      180

g                                                                      181


<210>  40431
<211>  592
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Post-transcription element

<400>  40431
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaagctga cgtcctttcc atggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgcc tg              592


<210>  40432
<211>  593
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Post-transcription element

<400>  40432
atcgataatc aacctctgga ttacaaaatt tgtgaaagat tgactggtat tcttaactat       60

gttgctcctt ttacgctatg tggatacgct gctttaatgc ctttgtatca tgctattgct      120

tcccgtatgg ctttcatttt ctcctccttg tataaatcct ggttgctgtc tctttatgag      180

gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc tgacgcaacc      240

cccactggtt ggggcattgc caccacctgt cagctccttt ccgggacttt cgctttcccc      300

ctccctattg ccacggcgga actcatcgcc gcctgccttg cccgctgctg gacaggggct      360

cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga aatcatcgtc ctttccttgg      420

ctgctcgcct gtgttgccac ctggattctg cgcgggacgt ccttctgcta cgtcccttcg      480

gccctcaatc cagcggacct tccttcccgc ggcctgctgc cggctctgcg gcctcttccg      540

cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt gggccgcctc ccc             593


<210>  40433
<211>  247
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Post-transcription element

<400>  40433
gataatcaac ctctggatta caaaatttgt gaaagattga ctggtattct taactatgtt       60

gctcctttta cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc tattgcttcc      120

cgtatggctt tcattttctc ctccttgtat aaatcctggt tagttcttgc cacggcggaa      180

ctcatcgccg cctgccttgc ccgctgctgg acaggggctc ggctgttggg cactgacaat      240

tccgtgg                                                                247


<210>  40434
<211>  584
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enhancer element

<400>  40434
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      540

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agct                       584


<210>  40435
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enhancer element

<400>  40435
gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      180

tgggaggtct atataagcag agct                                             204


<210>  40436
<211>  414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enhancer element

<400>  40436
aagatgcgtc aattaatttg cgtcaatttg cgctcaattt gcgtcaatct tgctgtcatt       60

tgcgtcaatt tgcgtcaata tgcgtcaata tatgcgtcaa ttcgaattcg cactaatgat      120

gactaatggt ggctaatggt gactaatggt gacaatgcgt gactaatggt gataatgagt      180

gcatatggtg actaatggtg actaatggtg gtgatgcggt tttggcagta catcaatggg      240

cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg      300

agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca      360

ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag agct            414


<210>  40437
<211>  314
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enhancer element

<400>  40437
tgggacagaa aacgagaaac cagggttgtc agcggggccc gcgccggccg ccccttggcc       60

cgcgggatac cccgggcgcc cagtgcccag gccgggcagg cggcactcac gtgatgcggt      120

tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc      180

accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat      240

gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct      300

atataagcag agct                                                        314


<210>  40438
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enhancer element

<400>  40438
cggaagcgag ggtgtcgctc gcccccgggc ccgggtccgc cccgctccga ggcctgctcg       60

gaagaaagac ctcggtgcgc agttctcgtc gcgctcccac acctggtccg cccagtcgga      120

gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt      180

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      240

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      300

tgggaggtct atataagcag agct                                             324


<210>  40439
<211>  304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enhancer element

<400>  40439
gtgatgcggt tttggcagta catcaatggg cgtggatagg cgggccggga gcgagggagg       60

cggcgccggg ggacgcgccg ggctcggcct ggcgaccgtt gcccgctcgc gtccatccat      120

ccattcattc gggcggcagc ggtttgactc acggggattt ccaagtctcc accccattga      180

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      240

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      300

agct                                                                   304


<210>  40440
<211>  304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enhancer element

<400>  40440
aggcgggccg ggagcgaggg aggcggcgcc gggggacgcg ccgggctcgg cctggcgacc       60

gttgcccgct cgcgtccatc catccattca ttcgggcggc gtgatgcggt tttggcagta      120

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      180

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      240

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      300

agct                                                                   304


<210>  40441
<211>  274
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enhancer element

<400>  40441
ccttcccctc cagtgctcct cggagccctt ccctatactt cctccaagct ccaccctcga       60

tcagccctgc gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc      120

acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa      180

tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag      240

gcgtgtacgg tgggaggtct atataagcag agct                                  274


<210>  40442
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enhancer element

<400>  40442
agaggtggtg gggctgagcc gaggtggggc cgtggccagg gggagggggt gctaggccgg       60

aaggggctgc agccgagggt ggccctgatt ttgtggccgg ccaggagcga aggggtccct      120

ttctgtcccc tgagcaccgt cgcctccttt gtgatgcggt tttggcagta catcaatggg      180

cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg      240

agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca      300

ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag agct            354


<210>  40443
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 5'

<400>  40443

Pro Lys Lys Lys Arg Lys Val Ser Arg 
1               5                   


<210>  40444
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 5'

<400>  40444

Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Pro Lys Lys Lys Arg Lys 
1               5                   10                  15      


Val Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Pro Lys 
            20                  25                  30          


Lys Lys Arg Lys Val Ser Arg 
        35                  


<210>  40445
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 5'

<400>  40445

Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Pro Lys Lys Lys Arg Lys 
1               5                   10                  15      


Val Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Pro Lys 
            20                  25                  30          


Lys Lys Arg Lys Val Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Gly 
        35                  40                  45              


Gly Ser Pro Lys Lys Lys Arg Lys Val Ser Arg 
    50                  55                  


<210>  40446
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 5'

<400>  40446

Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg 
1               5                   10      


<210>  40447
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 5'

<400>  40447

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys 
1               5                   10                  15      


Arg Val Lys Leu Asp Ser Arg 
            20              


<210>  40448
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 5'

<400>  40448

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys 
1               5                   10                  15      


Arg Val Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys Arg Val Lys Leu 
            20                  25                  30          


Asp Gly Gly Ser Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg 
        35                  40                  45          


<210>  40449
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 5'

<400>  40449

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys 
1               5                   10                  15      


Arg Val Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys Arg Val Lys Leu 
            20                  25                  30          


Asp Gly Gly Ser Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser 
        35                  40                  45              


Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys 
    50                  55                  60                  


Arg Val Lys Leu Asp Ser Arg 
65                  70      


<210>  40450
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 5'

<400>  40450

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


Ser Arg 
        


<210>  40451
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 5'

<400>  40451

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


Gly Gly Ser Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys 
            20                  25                  30          


Lys Lys Lys Ser Arg 
        35          


<210>  40452
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 5'

<400>  40452

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Arg 
            20      


<210>  40453
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 5'

<400>  40453

Pro Ala Ala Lys Lys Lys Lys Leu Asp Gly Gly Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Arg 
            20      


<210>  40454
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 5'

<400>  40454

Pro Ala Ala Lys Lys Lys Lys Leu Asp Ser Arg 
1               5                   10      


<210>  40455
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 5'

<400>  40455

Pro Ala Ala Lys Lys Lys Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys 
1               5                   10                  15      


Lys Lys Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys Lys Lys Lys Leu 
            20                  25                  30          


Asp Ser Arg 
        35  


<210>  40456
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 5'

<400>  40456

Pro Ala Ala Lys Lys Lys Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys 
1               5                   10                  15      


Lys Lys Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys Lys Lys Lys Leu 
            20                  25                  30          


Asp Gly Gly Ser Pro Ala Ala Lys Lys Lys Lys Leu Asp Ser Arg 
        35                  40                  45          


<210>  40457
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 5'

<400>  40457

Pro Ala Lys Arg Ala Arg Arg Gly Tyr Lys Cys Ser Arg 
1               5                   10              


<210>  40458
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 5'

<400>  40458

Pro Ala Lys Arg Ala Arg Arg Gly Tyr Lys Cys Gly Ser Pro Ala Lys 
1               5                   10                  15      


Arg Ala Arg Arg Gly Tyr Lys Cys Ser Arg 
            20                  25      


<210>  40459
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 5'

<400>  40459

Pro Arg Arg Lys Arg Glu Glu Ser Arg 
1               5                   


<210>  40460
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 5'

<400>  40460

Pro Tyr Arg Gly Arg Lys Glu Ser Arg 
1               5                   


<210>  40461
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40461

Gly Ser Pro Lys Lys Lys Arg Lys Val 
1               5                   


<210>  40462
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40462

Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Gly Ser 
            20                  25                  30          


Pro Lys Lys Lys Arg Lys Val 
        35                  


<210>  40463
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40463

Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Gly Ser 
            20                  25                  30          


Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Pro Lys Lys Lys Arg Lys 
        35                  40                  45              


Val Gly Gly Ser Pro Lys Lys Lys Arg Lys Val 
    50                  55                  


<210>  40464
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40464

Gly Ser Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   10      


<210>  40465
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40465

Gly Ser Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Ala 
1               5                   10                  15      


Ala Lys Arg Val Lys Leu Asp 
            20              


<210>  40466
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40466

Gly Ser Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Ala 
1               5                   10                  15      


Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys Arg Val 
            20                  25                  30          


Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys Arg Val Lys Leu Asp 
        35                  40                  45          


<210>  40467
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40467

Gly Ser Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Ala 
1               5                   10                  15      


Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys Arg Val 
            20                  25                  30          


Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys Arg Val Lys Leu Asp Gly 
        35                  40                  45              


Gly Ser Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Ala 
    50                  55                  60                  


Ala Lys Arg Val Lys Leu Asp 
65                  70      


<210>  40468
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40468

Gly Ser Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys 
1               5                   10                  15      


Lys Lys 
        


<210>  40469
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40469

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


Gly Gly Ser Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys 
            20                  25                  30          


Lys Lys Lys 
        35  


<210>  40470
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40470

Gly Ser Pro Ala Ala Lys Arg Val Lys Leu Gly Gly Ser Pro Ala Ala 
1               5                   10                  15      


Lys Arg Val Lys Leu Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Gly 
            20                  25                  30          


Gly Ser Pro Lys Lys Lys Arg Lys Val 
        35                  40      


<210>  40471
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40471

Gly Ser Lys Leu Gly Pro Arg Lys Ala Thr Gly Arg Trp Gly Ser 
1               5                   10                  15  


<210>  40472
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40472

Gly Ser Lys Arg Lys Gly Ser Pro Glu Arg Gly Glu Arg Lys Arg His 
1               5                   10                  15      


Trp Gly Ser 
            


<210>  40473
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40473

Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Ser Lys Arg Pro 
1               5                   10                  15      


Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys Leu Glu 
            20                  25                  30      


<210>  40474
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40474

Gly Pro Lys Arg Thr Ala Asp Ser Gln His Ser Thr Pro Pro Lys Thr 
1               5                   10                  15      


Lys Arg Lys Val Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30  


<210>  40475
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40475

Gly Gly Gly Ser Gly Gly Gly Ser Lys Arg Thr Ala Asp Ser Gln His 
1               5                   10                  15      


Ser Thr Pro Pro Lys Thr Lys Arg Lys Val Glu Phe Glu Pro Lys Lys 
            20                  25                  30          


Lys Arg Lys Val 
        35      


<210>  40476
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40476

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Ala Lys Arg Thr Ala Asp Ser Gln His Ser Thr Pro Pro Lys Thr Lys 
            20                  25                  30          


Arg Lys Val Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
        35                  40                  45  


<210>  40477
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40477

Gly Pro Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Lys Arg Thr Ala 
1               5                   10                  15      


Asp Ser Gln His Ser Thr Pro Pro Lys Thr Lys Arg Lys Val Glu Phe 
            20                  25                  30          


Glu Pro Lys Lys Lys Arg Lys Val 
        35                  40  


<210>  40478
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40478

Gly Pro Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala 
1               5                   10                  15      


Ala Lys Ala Pro Ala Ala Lys Arg Val Lys Leu Asp 
            20                  25              


<210>  40479
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40479

Gly Pro Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Pro Ala 
1               5                   10                  15      


Ala Lys Arg Val Lys Leu Asp 
            20              


<210>  40480
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40480

Gly Pro Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Ala Ala Lys 
1               5                   10                  15      


Arg Val Lys Leu Asp 
            20      


<210>  40481
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40481

Gly Pro Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   10      


<210>  40482
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40482

Gly Ser Pro Lys Lys Lys Arg Lys Val 
1               5                   


<210>  40483
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40483

Gly Ser Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   10      


<210>  40484
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40484

Val Gly Ser Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys 
1               5                   10                  15      


Lys Lys Lys 
            


<210>  40485
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40485

Thr Gly Gly Gly Pro Gly Gly Gly Ala Ala Ala Gly Ser Gly Ser Pro 
1               5                   10                  15      


Lys Lys Lys Arg Lys Val Gly Ser Gly Ser Lys Arg Pro Ala Ala Thr 
            20                  25                  30          


Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys Leu Glu 
        35                  40                  


<210>  40486
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40486

Thr Gly Gly Gly Pro Gly Gly Gly Ala Ala Ala Gly Ser Gly Ser Pro 
1               5                   10                  15      


Lys Lys Lys Arg Lys Val Gly Ser Gly Ser Lys Arg Pro Ala Ala Thr 
            20                  25                  30          


Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys Leu Glu 
        35                  40                  


<210>  40487
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40487

Thr Gly Gly Gly Pro Gly Gly Gly Ala Ala Ala Gly Ser Gly Ser Pro 
1               5                   10                  15      


Lys Lys Lys Arg Lys Val Gly Ser Gly Ser 
            20                  25      


<210>  40488
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40488

Pro Pro Pro Pro Lys Lys Lys Arg Lys Val Pro Pro Pro 
1               5                   10              


<210>  40489
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40489

Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro 
1               5                   10              


<210>  40490
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40490

Pro Pro Pro Pro Lys Lys Lys Arg Lys Val 
1               5                   10  


<210>  40491
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40491

Gly Gly Ser Pro Lys Lys Lys Arg Lys Val 
1               5                   10  


<210>  40492
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40492

Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Gly Gly Ser 
1               5                   10                  15      


Gly Gly Ser 
            


<210>  40493
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40493

Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Pro Lys Lys 
1               5                   10                  15      


Lys Arg Lys Val 
            20  


<210>  40494
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40494

Gly Gly Ser Gly Gly Ser Gly Gly Ser Pro Lys Lys Lys Arg Lys Val 
1               5                   10                  15      


Gly Gly Ser Pro Lys Lys Lys Arg Lys Val 
            20                  25      


<210>  40495
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40495

Val Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Pro Ala Ala 
1               5                   10                  15      


Lys Arg Val Lys Leu Asp 
            20          


<210>  40496
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40496

Val Pro Pro Pro Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   10              


<210>  40497
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40497

Val Pro Pro Pro Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Pro Ala Ala Lys Arg Val Lys Leu Asp 
            20                  25  


<210>  40498
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40498

Val Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Pro Ala Ala 
1               5                   10                  15      


Lys Arg Val Lys Leu Asp 
            20          


<210>  40499
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40499

Val Pro Pro Pro Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   10              


<210>  40500
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40500

Val Pro Pro Pro Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Pro Ala Ala Lys Arg Val Lys Leu Asp 
            20                  25  


<210>  40501
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS 3'

<400>  40501

Val Gly Ser Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   10          


<210>  40502
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  40502
aaggggctcc gcaccacgcc                                                   20


<210>  40503
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  40503
aagtggctcc gcaccacgcc                                                   20


<210>  40504
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  40504
aaggggctgc gtaccacacc                                                   20


<210>  40505
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  40505
gggtcttcga gaagaccc                                                     18


<210>  40506
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide sequence

<400>  40506
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaag                                         89


<210>  40507
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide sequence

<400>  40507
actggcactt ttatctgatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttacg gacttcggtc cgtaagaagc atcaaag                                97


<210>  40508
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide sequence

<400>  40508
actggcactt ctatctgatt actctgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttacg gacttcggtc cgtaagaagc atcaga                                 96


<210>  40509
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide sequence

<400>  40509
actggcgctt ctatctgatt actctgagag ccatcaccag cgactatgtc gtatgggtaa       60

agccgcttac ggacttcggt ccgtaagagg catcagag                               98


<210>  40510
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide sequence

<400>  40510
actggcgctt ctatctgatt actctgagag ccatcaccag cgactatgtc gtatgggtaa       60

agccgcttac ggacttcggt ccgtaagagg catcagag                               98


<210>  40511
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide sequence

<400>  40511
actggcactt ctatctgatt actctgagcg ccatcaccag cgactatgtc gtatgggtaa       60

agccgcttac ggacttcggt ccgtaagagg catcagag                               98


<210>  40512
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide sequence

<400>  40512
actggcgctt ctatctgatt actctgagcg ccatcaccag cgactatgtc gtatgggtaa       60

agccgcttac ggacttcggt ccgtaagagg catcagag                               98


<210>  40513
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide sequence

<400>  40513
actggcgctt ctatctgatt actctgagcg ccatcaccag cgactatgtc gtatgggtaa       60

agcgccttac ggacttcggt ccgtaaggag catcagag                               98


<210>  40514
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide sequence

<400>  40514
actggcgctt ctatctgatt actctgagcg ccatcaccag cgactatgtc gtagtgggta       60

aagccgctta cggacttcgg tccgtaagag gcatcagag                              99


<210>  40515
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide sequence

<400>  40515
acgggacttt ctatctgatt actctgaagt ccctcaccag cgactatgtc gtatgggtaa       60

agccgcttac ggacttcggt ccgtaagagg catcagag                               98


<210>  40516
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide sequence

<400>  40516
acctgtagtt ctatctgatt actctgacta cagtcaccag cgactatgtc gtatgggtaa       60

agccgcttac ggacttcggt ccgtaagagg catcagag                               98


<210>  40517
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40517
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaaga aggggctccg caccacgcc                  109


<210>  40518
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40518
actggcactt ttatctgatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttacg gacttcggtc cgtaagaagc atcaaagaag gggctccgca ccacgcc         117


<210>  40519
<211>  116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40519
actggcactt ctatctgatt actctgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttacg gacttcggtc cgtaagaagc atcagaaagg ggctccgcac cacgcc          116


<210>  40520
<211>  118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40520
actggcgctt ctatctgatt actctgagag ccatcaccag cgactatgtc gtatgggtaa       60

agccgcttac ggacttcggt ccgtaagagg catcagagaa ggggctccgc accacgcc        118


<210>  40521
<211>  118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40521
actggcactt ctatctgatt actctgagcg ccatcaccag cgactatgtc gtatgggtaa       60

agccgcttac ggacttcggt ccgtaagagg catcagagaa ggggctccgc accacgcc        118


<210>  40522
<211>  118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40522
actggcgctt ctatctgatt actctgagcg ccatcaccag cgactatgtc gtatgggtaa       60

agccgcttac ggacttcggt ccgtaagagg catcagagaa ggggctccgc accacgcc        118


<210>  40523
<211>  118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40523
actggcgctt ctatctgatt actctgagcg ccatcaccag cgactatgtc gtatgggtaa       60

agcgccttac ggacttcggt ccgtaaggag catcagagaa ggggctccgc accacgcc        118


<210>  40524
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40524
actggcgctt ctatctgatt actctgagcg ccatcaccag cgactatgtc gtagtgggta       60

aagccgctta cggacttcgg tccgtaagag gcatcagaga aggggctccg caccacgcc       119


<210>  40525
<211>  118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40525
acgggacttt ctatctgatt actctgaagt ccctcaccag cgactatgtc gtatgggtaa       60

agccgcttac ggacttcggt ccgtaagagg catcagagaa ggggctccgc accacgcc        118


<210>  40526
<211>  118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40526
acctgtagtt ctatctgatt actctgacta cagtcaccag cgactatgtc gtatgggtaa       60

agccgcttac ggacttcggt ccgtaagagg catcagagaa ggggctccgc accacgcc        118


<210>  40527
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40527
actggcgctt ctatctgatt actctgagcg ccatcaccag cgactatgtc gtagtgggta       60

aagccgctta cggacttcgg tccgtaagag gcatcagaga agtggctccg caccacgcc       119


<210>  40528
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40528
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaaga aggggctgcg taccacacc                  109


<210>  40529
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40529
actggcgctt ctatctgatt actctgagcg ccatcaccag cgactatgtc gtagtgggta       60

aagccgctta cggacttcgg tccgtaagag gcatcagaga aggggctgcg taccacacc       119


<210>  40530
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40530
actggcgctt ctatctgatt actctgagcg ccatcaccag cgactatgtc gtagtgggta       60

aagccgctta cggacttcgg tccgtaagag gcatcagagg ggtcttcgag aagaccc         117


<210>  40531
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  40531
aaggggctcc gcaccacgcc                                                   20


<210>  40532
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  40532
aaggggctcc gcaccacgc                                                    19


<210>  40533
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  40533
aaggggctcc gcaccacg                                                     18


<210>  40534
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  40534
aagtggctcc gcaccacgcc                                                   20


<210>  40535
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  40535
aagtggctcc gcaccacgc                                                    19


<210>  40536
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  40536
aagtggctcc gcaccacg                                                     18


<210>  40537
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  40537
aaggggctgc gtaccacacc                                                   20


<210>  40538
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  40538
aaggggctgc gtaccacac                                                    19


<210>  40539
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  40539
aaggggctgc gtaccaca                                                     18


<210>  40540
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  40540
aagtggctgc gtaccacacc                                                   20


<210>  40541
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  40541
aagtggctgc gtaccacac                                                    19


<210>  40542
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  40542
aagtggctgc gtaccaca                                                     18


<210>  40543
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide sequence

<400>  40543
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaag                                         89


<210>  40544
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide sequence

<400>  40544
actggcgctt ctatctgatt actctgagcg ccatcaccag cgactatgtc gtagtgggta       60

aagccgctta cggacttcgg tccgtaagag gcatcagag                              99


<210>  40545
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40545
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaaga aggggctccg caccacgcc                  109


<210>  40546
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40546
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaaga aggggctccg caccacgc                   108


<210>  40547
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40547
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaaga aggggctccg caccacg                    107


<210>  40548
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40548
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaaga agtggctccg caccacgcc                  109


<210>  40549
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40549
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaaga agtggctccg caccacgc                   108


<210>  40550
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40550
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaaga agtggctccg caccacg                    107


<210>  40551
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40551
actggcgctt ctatctgatt actctgagcg ccatcaccag cgactatgtc gtagtgggta       60

aagccgctta cggacttcgg tccgtaagag gcatcagaga aggggctgcg taccacacc       119


<210>  40552
<211>  118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40552
actggcgctt ctatctgatt actctgagcg ccatcaccag cgactatgtc gtagtgggta       60

aagccgctta cggacttcgg tccgtaagag gcatcagaga aggggctgcg taccacac        118


<210>  40553
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40553
actggcgctt ctatctgatt actctgagcg ccatcaccag cgactatgtc gtagtgggta       60

aagccgctta cggacttcgg tccgtaagag gcatcagaga aggggctgcg taccaca         117


<210>  40554
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40554
actggcgctt ctatctgatt actctgagcg ccatcaccag cgactatgtc gtagtgggta       60

aagccgctta cggacttcgg tccgtaagag gcatcagaga agtggctgcg taccacacc       119


<210>  40555
<211>  118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40555
actggcgctt ctatctgatt actctgagcg ccatcaccag cgactatgtc gtagtgggta       60

aagccgctta cggacttcgg tccgtaagag gcatcagaga agtggctgcg taccacac        118


<210>  40556
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA guide with spacer sequence

<400>  40556
actggcgctt ctatctgatt actctgagcg ccatcaccag cgactatgtc gtagtgggta       60

aagccgctta cggacttcgg tccgtaagag gcatcagaga agtggctgcg taccaca         117


<210>  40557
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' ITR

<400>  40557
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  40558
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  buffer seq

<400>  40558
gcggcctcta gactcgaggc gtt                                               23


<210>  40559
<211>  380
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  enhancer

<400>  40559
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg                                                  380


<210>  40560
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol II promoter

<400>  40560
gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      180

tgggaggtct atataagcag agct                                             204


<210>  40561
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  buffer seq

<400>  40561
ctctggctaa ctacc                                                        15


<210>  40562
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  kozac

<400>  40562
ggtgccacca tg                                                           12


<210>  40563
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  start codon

<400>  40563
atggcc                                                                   6


<210>  40564
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' NLS

<400>  40564
ccaaagaaga agcggaaggt c                                                 21


<210>  40565
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' linker

<400>  40565
tctaga                                                                   6


<210>  40566
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' NLS linker

<400>  40566
ggatcc                                                                   6


<210>  40567
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' NLS

<400>  40567
ccaaaaaaga agagaaaggt a                                                 21


<210>  40568
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  tag

<400>  40568
tacccatatg atgtccctga ctacgct                                           27


<210>  40569
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker

<400>  40569
ggatcctaa                                                                9


<210>  40570
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  buffer seq

<400>  40570
gaattcctag agctcgctga tcagcctcga                                        30


<210>  40571
<211>  208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly(A)

<400>  40571
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagagaa tagcaggcat gctgggga                                         208


<210>  40572
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  buffer seq

<400>  40572
ggtaccgt                                                                 8


<210>  40573
<211>  241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  40573
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

c                                                                      241


<210>  40574
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  buffer

<400>  40574
gaaacacc                                                                 8


<210>  40575
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  buffer

<400>  40575
ttttttttgg cggccgc                                                      17


<210>  40576
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' ITR

<400>  40576
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag ctgcctgcag g                                                141


<210>  40577
<211>  2931
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40577
atgcaagaga tcaagagaat caacaagatc agaaggagac tggtcaagga cagcaacaca       60

aagaaggccg gcaagacagg ccccatgaaa accctgctcg tcagagtgat gacccctgac      120

ctgagagagc ggctggaaaa cctgagaaag aagcccgaga acatccctca gcctatcagc      180

aacaccagca gggccaacct gaacaagctg ctgaccgact acaccgagat gaagaaagcc      240

atcctgcacg tgtactggga agagttccag aaagaccccg tgggcctgat gagcagagtt      300

gctcagcccg ctcctaagaa catcgaccag agaaagctga tccccgtgaa ggacggcaac      360

gagagactga cctctagcgg ctttgcctgc agccagtgtt gccagcctct gtacgtgtac      420

aagctggaac aagtgaacga caagggcaag ccccacacca actacttcgg cagatgcaac      480

gtgtccgagc acgagaggct gatcctgctg tctcctcaca agcccgaggc caacgatgag      540

ctggtcacat acagcctggg caagttcgga cagagagccc tggacttcta cagcatccac      600

gtgaccaggg agagcaatca ccctgtgaag cccctggaac agatcggcgg caatagctgt      660

gcctctggac ctgtgggaaa agccctgagc gacgcctgta tgggagccgt ggcatccttc      720

ctgaccaagt accaggacat catcctggaa caccagaaag tgatcaagaa gaacgagaaa      780

agactggcca acctcaagga tatcgccagc gctaacggcc tggcctttcc taagatcacc      840

ctgcctccac agcctcacac caaagagggc atcgaggcct acaacaacgt ggtggcccag      900

atcgtgattt gggtcaacct gaatctgtgg cagaagctga agatcggcag ggacgaagcc      960

aagccactgc agagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     1200

gacctgctga agcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     2400

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     2460

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     2520

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggaggaa gaggcagaac     2580

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     2640

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     2700

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     2760

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     2820

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     2880

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt g              2931


<210>  40578
<211>  2931
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40578
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacagc gcagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     2400

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     2460

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     2520

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggtacaa gaggcagaac     2580

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     2640

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     2700

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     2760

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     2820

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     2880

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt g              2931


<210>  40579
<211>  2934
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40579
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacacgggg ccccatgaaa accctgctcg tcagagtgat gacccctgac      120

ctgagagagc ggctggaaaa cctgagaaag aagcccgaga acatccctca gcctatcagc      180

aacaccagca gggccaacct gaacaagctg ctgaccgact acaccgagat gaagaaagcc      240

atcctgcacg tgtactggga agagttccag aaagaccccg tgggcctgat gagcagagtt      300

gctcagcctg ccagcaagaa gatcgaccag aacaagctga agcccgagat ggacgagaag      360

ggcaatctga ccacagccgg ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac      420

aagctggaac aggtgtccga gaaaggcaag gcctacacca actacttcgg cagatgtaac      480

gtggccgagc acgagaagct gattctgctg gcccagctga aacctgagaa ggactctgat      540

gaggccgtga cctacagcct gggcaagttt ggacagagag ccctggactt ctacagcatc      600

cacgtgacca aagaaagcac acaccccgtg aagcccctgg ctcagatcgc cggcaataga      660

tacgcctctg gacctgtggg caaagccctg tccgatgcct gcatgggaac aatcgccagc      720

ttcctgagca agtaccagga catcatcatc gagcaccaga aggtggtcaa gggcaaccag      780

aagagactgg aaagcctgag ggagctggcc ggcaaagaga acctggaata ccccagcgtg      840

accctgcctc ctcagcctca cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc      900

agagtgagaa tgtgggtcaa cctgaacctg tggcagaagc tgaaactgtc cagggacgac      960

gccaagcctc tgctgagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc     1020

aatgaagtgg attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa     1080

gaggatggca aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg     1140

ccttacctga gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg     1200

ggcgacctgc tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat     1260

gaggcctggg agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa     1320

gaggaaagaa ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc     1380

aaggccagct ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc     1440

gagctgaagc tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc     1500

gagaacagca tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg     1560

cagaaagacg gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc     1620

aagctgcggt tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg     1680

atcaacaaaa agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc     1740

aacctgatta tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac     1800

gatctgctga gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa     1860

accctgtaca acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc     1920

gagagaagag aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac     1980

cggggcgaga atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc     2040

agattcaagg actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa     2100

gagaagcaga ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac     2160

tctaggaagt acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc     2220

agagatctgc tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc     2280

agaggcttcg gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg     2340

gaagattggc tcacagctaa actggcctac gagggactga gcaagaccta cctgtccaaa     2400

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     2460

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     2520

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     2580

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     2640

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     2700

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     2760

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     2820

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     2880

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtg           2934


<210>  40580
<211>  2934
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40580
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctcttccc ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgccca gcaagaccta cctgtccaaa     2400

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     2460

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     2520

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     2580

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     2640

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     2700

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     2760

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     2820

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     2880

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtg           2934


<210>  40581
<211>  2934
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40581
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctaccc ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgccca gcaagaccta cctgtccaaa     2400

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     2460

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     2520

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     2580

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     2640

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     2700

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     2760

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     2820

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     2880

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtg           2934


<210>  40582
<211>  2934
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40582
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctgccc ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgccca gcaagaccta cctgtccaaa     2400

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     2460

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     2520

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     2580

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     2640

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     2700

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     2760

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     2820

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     2880

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtg           2934


<210>  40583
<211>  2934
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40583
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat taagctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgccca gcaagaccta cctgtccaaa     2400

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     2460

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     2520

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     2580

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     2640

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     2700

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     2760

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     2820

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     2880

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtg           2934


<210>  40584
<211>  2937
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40584
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacacgggg ccccatgaaa accctgctcg tcagagtgat gacccctgac      120

ctgagagagc ggctggaaaa cctgagaaag aagcccgaga acatccctca gcctatcagc      180

aacaccagca gggccaacct gaacaagctg ctgaccgact acaccgagat gaagaaagcc      240

atcctgcacg tgtactggga agagttccag aaagaccccg tgggcctgat gagcagagtt      300

gctcagcctg ccagcaagaa gatcgaccag aacaagctga agcccgagat ggacgagaag      360

ggcaatctga ccacagccgg ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac      420

aagctggaac aggtgtccga gaaaggcaag gcctacacca actacttcgg cagatgtaac      480

gtggccgagc acgagaagct gattctgctg gcccagctga aacctgagaa ggactctgat      540

gaggccgtga cctacagcct gggcaagttt ggacagagag ccctggactt ctacagcatc      600

cacgtgacca aagaaagcac acaccccgtg aagcccctgg ctcagatcgc cggcaataga      660

tacgcctctt cccctgtggg caaagccctg tccgatgcct gcatgggaac aatcgccagc      720

ttcctgagca agtaccagga catcatcatc gagcaccaga aggtggtcaa gggcaaccag      780

aagagactgg aaagcctgag ggagctggcc ggcaaagaga acctggaata ccccagcgtg      840

accctgcctc ctcagcctca cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc      900

agagtgagaa tgtgggtcaa cctgaacctg tggcagaagc tgaaactgtc cagggacgac      960

gccaagcctc tgctgagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc     1020

aatgaagtgg attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa     1080

gaggatggca aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg     1140

ccttacctga gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg     1200

ggcgacctgc tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat     1260

gaggcctggg agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa     1320

gaggaaagaa ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc     1380

aaggccagct ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc     1440

gagctgaagc tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc     1500

gagaacagca tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg     1560

cagaaagacg gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc     1620

aagctgcggt tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg     1680

atcaacaaaa agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc     1740

aacctgatta tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac     1800

gatctgctga gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa     1860

accctgtaca acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc     1920

gagagaagag aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac     1980

cggggcgaga atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc     2040

agattcaagg actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa     2100

gagaagcaga ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac     2160

tctaggaagt acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc     2220

agagatctgc tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc     2280

agaggcttcg gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg     2340

gaagattggc tcacagctaa actggcctac gagggactgc ccagcaagac ctacctgtcc     2400

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     2460

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     2520

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     2580

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     2640

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     2700

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     2760

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     2820

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     2880

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtg        2937


<210>  40585
<211>  2934
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40585
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat taagctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctcttccc ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgccca gcaagaccta cctgtccaaa     2400

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     2460

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     2520

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     2580

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     2640

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     2700

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     2760

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     2820

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     2880

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtg           2934


<210>  40586
<211>  2937
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40586
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacacgggg ccccatgaaa accctgctcg tcagagtgat gacccctgac      120

ctgagagagc ggctggaaaa cctgagaaag aagcccgaga acatccctca gcctatcagc      180

aacaccagca gggccaacct gaacaagctg ctgaccgact acaccgagat gaagaaagcc      240

atcctgcacg tgtactggga agagttccag aaagaccccg tgggcctgat gagcagagtt      300

gctcagcctg ccagcaagaa gatcgaccag aacaagctga agcccgagat ggacgagaag      360

ggcaatctga ccacagccgg ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac      420

aagctggaac aggtgtccga gaaaggcaag gcctacacca actacttcgg cagatgtaac      480

gtggccgagc acgagaagct gattctgctg gcccagctga aacctgagaa ggactctgat      540

gaggccgtga cctacagcct gggcaagttt ggacagagag ccctggactt ctacagcatc      600

cacgtgacca aagaaagcac acaccccgtg aagcccctgg ctcagatcgc cggcaataga      660

tacgcctctg gacctgtggg caaagccctg tccggcgcct gcatgggaac aatcgccagc      720

ttcctgagca agtaccagga catcatcatc gagcaccaga aggtggtcaa gggcaaccag      780

aagagactgg aaagcctgag ggagctggcc ggcaaagaga acctggaata ccccagcgtg      840

accctgcctc ctcagcctca cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc      900

agagtgagaa tgtgggtcaa cctgaacctg tggcagaagc tgaaactgtc cagggacgac      960

gccaagcctc tgctgagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc     1020

aatgaagtgg attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa     1080

gaggatggca aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg     1140

ccttacctga gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg     1200

ggcgacctgc tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat     1260

gaggcctggg agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa     1320

gaggaaagaa ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc     1380

aaggccagct ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc     1440

gagctgaagc tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc     1500

gagaacagca tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg     1560

cagaaagacg gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc     1620

aagctgcggt tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg     1680

atcaacaaaa agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc     1740

aacctgatta tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac     1800

gatctgctga gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa     1860

accctgtaca acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc     1920

gagagaagag aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac     1980

cggggcgaga atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc     2040

agattcaagg actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa     2100

gagaagcaga ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac     2160

tctaggaagt acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc     2220

agagatctgc tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc     2280

agaggcttcg gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg     2340

gaagattggc tcacagctaa actggcctac gagggactgc ccagcaagac ctacctgtcc     2400

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     2460

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     2520

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     2580

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     2640

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     2700

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     2760

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     2820

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     2880

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtg        2937


<210>  40587
<211>  2937
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40587
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacacgggg ccccatgaaa accctgctcg tcagagtgat gacccctgac      120

ctgagagagc ggctggaaaa cctgagaaag aagcccgaga acatccctca gcctatcagc      180

aacaccagca gggccaacct gaacaagctg ctgaccgact acaccgagat gaagaaagcc      240

atcctgcacg tgtactggga agagttccag aaagaccccg tgggcctgat gagcagagtt      300

gctcagcctg ccagcaagaa gatcgaccag aacaagctga agcccgagat ggacgagaag      360

ggcaatctga ccacagccgg ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac      420

aagctggaac aggtgtccga gaaaggcaag gcctacacca actacttcgg cagatgtaac      480

gtggccgagc acgagaagct gattctgctg gcccagctga aacctgagaa ggactctgat      540

gaggccgtga cctacagcct gggcaagttt ggacagagag ccctggactt ctacagcatc      600

cacgtgacca aagaaagcac acaccccgtg aagcccctgg ctcagatcgc cggcaataga      660

tacgcctctt cccctgtggg caaagccctg tccggcgcct gcatgggaac aatcgccagc      720

ttcctgagca agtaccagga catcatcatc gagcaccaga aggtggtcaa gggcaaccag      780

aagagactgg aaagcctgag ggagctggcc ggcaaagaga acctggaata ccccagcgtg      840

accctgcctc ctcagcctca cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc      900

agagtgagaa tgtgggtcaa cctgaacctg tggcagaagc tgaaactgtc cagggacgac      960

gccaagcctc tgctgagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc     1020

aatgaagtgg attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa     1080

gaggatggca aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg     1140

ccttacctga gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg     1200

ggcgacctgc tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat     1260

gaggcctggg agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa     1320

gaggaaagaa ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc     1380

aaggccagct ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc     1440

gagctgaagc tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc     1500

gagaacagca tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg     1560

cagaaagacg gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc     1620

aagctgcggt tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg     1680

atcaacaaaa agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc     1740

aacctgatta tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac     1800

gatctgctga gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa     1860

accctgtaca acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc     1920

gagagaagag aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac     1980

cggggcgaga atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc     2040

agattcaagg actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa     2100

gagaagcaga ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac     2160

tctaggaagt acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc     2220

agagatctgc tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc     2280

agaggcttcg gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg     2340

gaagattggc tcacagctaa actggcctac gagggactgc ccagcaagac ctacctgtcc     2400

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     2460

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     2520

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     2580

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     2640

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     2700

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     2760

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     2820

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     2880

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtg        2937


<210>  40588
<211>  2937
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40588
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacacgggg ccccatgaaa accctgctcg tcagagtgat gacccctgac      120

ctgagagagc ggctggaaaa cctgagaaag aagcccgaga acatccctca gcctatcagc      180

aacaccagca gggccaacct gaacaagctg ctgaccgact acaccgagat gaagaaagcc      240

atcctgcacg tgtactggga agagttccag aaagaccccg tgggcctgat gagcagagtt      300

gctcagcctg ccagcaagaa gatcgaccag aacaagctga agcccgagat ggacgagaag      360

ggcaatctga ccacagccgg ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac      420

aagctggaac aggtgtccga gaaaggcaag gcctacacca actacttcgg cagatgtaac      480

gtggccgagc acgagaagct gattaagctg gcccagctga aacctgagaa ggactctgat      540

gaggccgtga cctacagcct gggcaagttt ggacagagag ccctggactt ctacagcatc      600

cacgtgacca aagaaagcac acaccccgtg aagcccctgg ctcagatcgc cggcaataga      660

tacgcctctt cccctgtggg caaagccctg tccgatgcct gcatgggaac aatcgccagc      720

ttcctgagca agtaccagga catcatcatc gagcaccaga aggtggtcaa gggcaaccag      780

aagagactgg aaagcctgag ggagctggcc ggcaaagaga acctggaata ccccagcgtg      840

accctgcctc ctcagcctca cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc      900

agagtgagaa tgtgggtcaa cctgaacctg tggcagaagc tgaaactgtc cagggacgac      960

gccaagcctc tgctgagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc     1020

aatgaagtgg attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa     1080

gaggatggca aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg     1140

ccttacctga gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg     1200

ggcgacctgc tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat     1260

gaggcctggg agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa     1320

gaggaaagaa ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc     1380

aaggccagct ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc     1440

gagctgaagc tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc     1500

gagaacagca tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg     1560

cagaaagacg gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc     1620

aagctgcggt tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg     1680

atcaacaaaa agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc     1740

aacctgatta tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac     1800

gatctgctga gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa     1860

accctgtaca acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc     1920

gagagaagag aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac     1980

cggggcgaga atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc     2040

agattcaagg actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa     2100

gagaagcaga ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac     2160

tctaggaagt acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc     2220

agagatctgc tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc     2280

agaggcttcg gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg     2340

gaagattggc tcacagctaa actggcctac gagggactgc ccagcaagac ctacctgtcc     2400

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     2460

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     2520

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     2580

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     2640

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     2700

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     2760

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     2820

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     2880

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtg        2937


<210>  40589
<211>  825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO promoter

<400>  40589
agatcttccc cacctagcca cctggcaaac tgctccttct ctcaaaggcc caaacatggc       60

ctcccagact gcaaccccca ggcagtcagg ccctgtctcc acaacctcac agccaccctg      120

gacggaatct gcttcttccc acatttgagt cctcctcagc ccctgagctc ctctgggcag      180

ggctgtttct ttccatcttt gtattcccag gggcctgcaa ataaatgttt aatgaacgaa      240

caagagagtg aattccaatt ccatgcaaca aggattgggc tcctgggccc taggctatgt      300

gtctggcacc agaaacggaa gctgcaggtt gcagcccctg ccctcatgga gctcctcctg      360

tcagaggagt gtggggactg gatgactcca gaggtaactt gtgggggaac gaacaggtaa      420

ggggctgtgt gacgagatga gagactggga gaataaacca gaaagtctct agctgtccag      480

aggacatagc acagaggccc atggtcccta tttcaaaccc aggccaccag actgagctgg      540

gaccttggga cagacaagtc atgcagaagt taggggacct tctcctccct tttcctggat      600

cctgagtacc tctcctccct gacctcaggc ttcctcctag tgtcaccttg gcccctctta      660

gaagccaatt aggccctcag tttctgcagc ggggattaat atgattatga acacccccaa      720

tctcccagat gctgattcag ccaggagctt aggaggggga ggtcacttta taagggtctg      780

ggggggtcag aacccagagt catcccctga attctgcaga tatcc                      825


<210>  40590
<211>  805
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO535-CAG promoter

<400>  40590
cctcatggag ctcctcctgt cagaggagtg tggggactgg atgactccag aggtaacttg       60

tgggggaacg aacaggtaag gggctgtgtg acgagatgag agactgggag aataaaccag      120

aaagtctcta gctgtccaga ggacatagca cagaggccca tggtccctat ttcaaaccca      180

ggccaccaga ctgagctggg accttgggac agacaagtca tgcagaagtt aggggacctt      240

ctcctccctt ttcctggatc ctgagtacct ctcctccctg acctcaggct tcctcctagt      300

gtcaccttgg cccctcttag aagccaatta ggccctcagt ttctgcagcg gggattaata      360

tgattatgaa cacccccaat ctcccagatg ctgattcagc caggagctta ggagggggag      420

gtcactttat aagggtctgg gggggtcaga acccagagtc atccagctgg agccctgagt      480

ggctgagctc aggccttcgc agcattcttg ggtgggagca gccacgggtc agccacaacc      540

acgttctgct tcactctccc catctccccc cccctcccca cccccaattt tgtatttatt      600

tattttttaa ttattttgtg cagcgatggg ggcggggggg gggggggggc gcgcgccagg      660

cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa      720

tcagagcggc gcgctccgaa agtttccttt tatggcgagg cggcggcggc ggcggcccta      780

taaaaagcga agcgcgcggc gggcg                                            805


<210>  40591
<211>  1022
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHO-intron promoter

<400>  40591
agatcttccc cacctagcca cctggcaaac tgctccttct ctcaaaggcc caaacatggc       60

ctcccagact gcaaccccca ggcagtcagg ccctgtctcc acaacctcac agccaccctg      120

gacggaatct gcttcttccc acatttgagt cctcctcagc ccctgagctc ctctgggcag      180

ggctgtttct ttccatcttt gtattcccag gggcctgcaa ataaatgttt aatgaacgaa      240

caagagagtg aattccaatt ccatgcaaca aggattgggc tcctgggccc taggctatgt      300

gtctggcacc agaaacggaa gctgcaggtt gcagcccctg ccctcatgga gctcctcctg      360

tcagaggagt gtggggactg gatgactcca gaggtaactt gtgggggaac gaacaggtaa      420

ggggctgtgt gacgagatga gagactggga gaataaacca gaaagtctct agctgtccag      480

aggacatagc acagaggccc atggtcccta tttcaaaccc aggccaccag actgagctgg      540

gaccttggga cagacaagtc atgcagaagt taggggacct tctcctccct tttcctggat      600

cctgagtacc tctcctccct gacctcaggc ttcctcctag tgtcaccttg gcccctctta      660

gaagccaatt aggccctcag tttctgcagc ggggattaat atgattatga acacccccaa      720

tctcccagat gctgattcag ccaggagctt aggaggggga ggtcacttta taagggtctg      780

ggggggtcag aacccagagt catcccctga attctgcaga tatccatcac actgcgagga      840

actgaaaaac cagaaagtta actggtaagt ttagtctttt tgtcttttat ttcaggtccc      900

ggatccggtg gtggtgcaaa tcaaagaact gctcctcagt ggatgttgcc tttacttcta      960

ggcctgtacg gaagtgttac ttctgctcta aaagctgcgg aattgtaccc gcggccgatc     1020

ca                                                                    1022


<210>  40592
<211>  292
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GRK promoter

<400>  40592
gggccccaga agcctggtgg ttgtttgtcc ttctcagggg aaaagtgagg cggccccttg       60

gaggaagggg ccgggcagaa tgatctaatc ggattccaag cagctcaggg gattgtcttt      120

ttctagcacc ttcttgccac tcctaagcgt cctccgtgac cccggctggg atttcgcctg      180

gtgctgtgtc agccccggtc tcccaggggc ttcccagtgg tccccaggaa ccctcgacag      240

ggcccggtct ctctcgtcca gcaagggcag ggacgggcca caggccaagg gc              292


<210>  40593
<211>  510
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GRK-SV40 promoter

<400>  40593
gctagcaaga tccaagctca gatctcgatc gagttgggcc ccagaagcct ggtggttgtt       60

tgtccttctc aggggaaaag tgaggcggcc ccttggagga aggggccggg cagaatgatc      120

taatcggatt ccaagcagct caggggattg tctttttcta gcaccttctt gccactccta      180

agcgtcctcc gtgaccccgg ctgggattta gcctggtgct gtgtcagccc cggtctccca      240

ggggcttccc agtggtcccc aggaaccctc gacagggccc ggtctctctc gtccagcaag      300

ggcagggacg ggccacaggc caagggccct cgatcgagga actgaaaaac cagaaagtta      360

actggtaagt ttagtctttt tgtcttttat ttcaggtccc ggatccggtg gtggtgcaaa      420

tcaaagaact gctcctcagt ggatgttgcc tttacttcta ggcctgtacg gaagtgttac      480

ttctgctcta aaagctgcgg aattgtaccc                                       510


<210>  40594
<211>  560
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GRK-CAG promoter

<400>  40594
gggccccaga agcctggtgg ttgtttgtcc ttctcagggg aaaagtgagg cggccccttg       60

gaggaagggg ccgggcagaa tgatctaatc ggattccaag cagctcaggg gattgtcttt      120

ttctagcacc ttcttgccac tcctaagcgt cctccgtgac cccggctggg atttcgcctg      180

gtgctgtgtc agccccggtc tcccaggggc ttcccagtgg tccccaggaa ccctcgacag      240

ggcccggtct ctctcgtcca gcaagggcag ggacgggcca caggccaagg gcaccacgtt      300

ctgcttcact ctccccatct ccccccccct ccccaccccc aattttgtat ttatttattt      360

tttaattatt ttgtgcagcg atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg      420

cggggcgggg cgaggggcgg ggcggggcga ggcggagagg tgcggcggca gccaatcaga      480

gcggcgcgct ccgaaagttt ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa      540

agcgaagcgc gcggcgggcg                                                  560


<210>  40595
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NGS primer sequence Rho exon-F


<220>
<221>  misc_feature
<222>  (34)..(40)
<223>  n is any nucleotide

<400>  40595
acactctttc cctacacgac gctcttccga tctnnnnnnn gcagccttgg tctctgtcta       60

cg                                                                      62


<210>  40596
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NGS primer sequence Rho exon-R

<400>  40596
gtgactggag ttcagacgtg tgctcttccg atctgcccca gtctctctgc tcatacc          57


<210>  40597
<211>  73
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NGS primer sequence GFP-F


<220>
<221>  misc_feature
<222>  (34)..(49)
<223>  n is any nucleotide

<400>  40597
acactctttc cctacacgac gctcttccga tctnnnnnnn nnnnnnnnng acgtaaacgg       60

ccacaagttc agc                                                          73


<210>  40598
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NGS primer sequence GFP-R

<400>  40598
gtgactggag ttcagacgtg tgctcttccg atctcgttct tctgcttgtc ggccatga         58


<210>  40599
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40599
gtggcccagg caggcagacc caccaggggt ccctgaaggc cagcccttga gaag             54


<210>  40600
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40600
gtcatacaac tttcctgaag ttgtatgacc tctctgagcc ttagtctcct cgtttgtaaa       60

atgagag                                                                 67


<210>  40601
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40601
gtaagagcat agtgcacagg actgctggtg gccaggaggc ccagccctgg atcttcctcc       60

ag                                                                      62


<210>  40602
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40602
gtatgagaca ccacacctgc ccatttttgt ttggtttttt aatgggcag                   49


<210>  40603
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40603
gtacaaatat atatcaaatt catagatatc tattggtacc tcatataagt accatagag        59


<210>  40604
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40604
gttccggagc cccggcgcgg gcgggttctg gggtgtagac gctgctggcc agcccgcccc       60

agccgag                                                                 67


<210>  40605
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40605
gtgtttgacg gcatcccacc gccctacgac aagaaaaagc ggatggtggt tcctgctgcc       60

ctcaag                                                                  66


<210>  40606
<211>  86
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40606
gtcgccaggt agggctgggg gccgagggac cggctcgggg gcggggggga agtgtgcctg       60

accggtctct gtcctcagcg agggag                                            86


<210>  40607
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40607
gtgggtccca gccccgcccg ctgcccggcc gccccgcagg tcccccgtga caccggctcc       60

tcctcag                                                                 67


<210>  40608
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40608
gtaagtgcag aggctggcag agggcagccc atgcccccac ctgccacctc acaagcctct       60

cctcccacag                                                              70


<210>  40609
<211>  476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40609
gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60

cataggaagg ggagaagtaa cagggtacac atattgacca aatcagggta attttgcatt      120

tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat      180

actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg cctctttgca      240

ccattctaaa gaataacagt gataatttct gggttaaggc aatagcaata tttctgcata      300

taaatatttc tgcatataaa ttgtaactga tgtaagaggt ttcatattgc taatagcagc      360

tacaatccag ctaccattct gcttttattt tatggttggg ataaggctgg attattctga      420

gtccaagcta ggcccttttg ctaatcatgt tcatacctct tatcttcctc ccacag          476


<210>  40610
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40610
gtaagtggag actagggggc tggggttgca ccctcccagt ctgactcctc actgccgccg       60

cctcctcag                                                               69


<210>  40611
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40611
gtgagctggc gcccccaggg cggctccggg cccaggcccg tccagggcat aaccccctgt       60

ctcccctag                                                               69


<210>  40612
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40612
gtaggcgcct ggggcgggca ggagggtaca cgggcgtaaa ctgagtctca ccgctttcct       60

ctccctgcag                                                              70


<210>  40613
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40613
gtgagttggg actaggggtt gggtctgggt ccagacccgg cccagccatc acacacctgc       60

cctccctcag                                                              70


<210>  40614
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40614
gtacgatggc acctccggca aagagagcca ggagaggtaa gggtgtgtta gtaaagtggg       60

gggaggggaa agatttaata acttaactaa gtatgtgttt ttttatag                   108


<210>  40615
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40615
gtgagctgcg cgcgcgcggc ggggggcggg cgcccggacc ccgctgaggc tgcgcccctg       60

tccccgcag                                                               69


<210>  40616
<211>  206
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40616
gttcgagctt ttggagtacg tcgtctttag gttgggggga ggggttttat gcgatggagt       60

ttccccacac tgagtgggtg gagactgaag ttaggccagc ttggcacttg atgtaattct      120

ccttggaatt tgcccttttt gagtttggat cttggttcat tctcaagcct cagacagtgg      180

ttcaaagttt ttttcttcca tttcag                                           206


<210>  40617
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40617
gtgtgtgctg ggcagggttg ggggctgggg gccagggcat gccaggctct gattgccacc       60

ccctttttag                                                              70


<210>  40618
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40618
gtaaggcagg ctccctgggg cggcaggtgg gttgcatgga gccaggctga ccctccatgt       60

ccccccag                                                                68


<210>  40619
<211>  299
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40619
gtttgtttcc ttttttaaaa tacattgagt atgcttgcct tttagatata gaaatatctg       60

atgctgtcta cttcactaaa ttttgattac atgatttgac agcaatattg aagagtctaa      120

cagccagcac gcaggttggt aagtactgtg ggaacatcac agattttggc tccatgccct      180

aaagagaaat tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta      240

aaattttcat gatgttttct tttttgctaa aactaaagaa ttattctttt acatttcag       299


<210>  40620
<211>  226
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40620
gtcgctgcga cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc       60

ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc      120

gggctgtaat tagctgagca agaggtaagg gtttaaggga tggttggttg gtggggtatt      180

aatgtttaat tacctggagc acctgcctga aatcactttt tttcag                     226


<210>  40621
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40621
gtaagagtca gagctggcag ggacgtacag tggccacgac tggggtactg agctgcagtt       60

cacctggcag a                                                            71


<210>  40622
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40622
gtgggtaggg tttgggggag agcgtgggct ggggttcagg gacaccctct caccactgcc       60

ctcccacag                                                               69


<210>  40623
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40623
gtaagtatac aattggatgt gctaaattga acaaaatagg ttcttgtgct attttactta       60

ggtttctctt tttttcccca cacatag                                           87


<210>  40624
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40624
aggtaagggt ttaagggatg gttggttggt ggggtattaa tgtttaatta cctggagcac       60

ctgcctgaaa tcactttttt tcag                                              84


<210>  40625
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40625
gtaagggttt aagggatggt tggttggtgg ggtattaatg tttaattacc tgttttacag       60

gcctgaaatc acttggtttt ag                                                82


<210>  40626
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40626
gtgagccagg ccgtgggagg gcgcccccga gactgccacc tgctcaccac ccccctctgc       60

tcgtag                                                                  66


<210>  40627
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40627
gtgagtgggc gccccggcgg ggtgggcagt gggcgggccc gagctgaccg cacccctccc       60

cacag                                                                   65


<210>  40628
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40628
gtgcgtgagc ggggactggc ggggggtgcc cccacgggac cgcgctgaac ccggcccccc       60

acacag                                                                  66


<210>  40629
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40629
gtaggatggc gcctcctgca aaaagagcaa gaggtaaggg tagttttaag ggggtggtgg       60

gcatacatat aaaactaact gcaaataatt tttttatata ttacag                     106


<210>  40630
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40630
gtaggccctg gcctgcaggg actgtgggtg ccccctgtcc agtaccctca ccatgaccct       60

gttgcccag                                                               69


<210>  40631
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40631
gtgagtcagg gtggggctgg ccccctgctt cgtgcccatc cgcgctctga ctctctgccc       60

acctgcag                                                                68


<210>  40632
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40632
gtactacggc ctgggtaggg aatggtgggt gggggcgggg gaccccttac caaggccacc       60

ctctgcag                                                                68


<210>  40633
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40633
gtaagtttag tctttttgtc ttttatttca ggtcccggat ccggtggtgg tgcaaatcaa       60

agaactgctc ctcagtggat gttgccttta cttctag                                97


<210>  40634
<211>  140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40634
gtaagtcact gactgtctat gcctgggaaa gggtgggcag gagatggggc agtgcaggaa       60

aagtggcact atgaaccctg cagccctagg aatgcatcta gacaattgta ctaaccttct      120

tctctttcct ctcctgacag                                                  140


<210>  40635
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40635
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagaggagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  40636
<211>  190
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40636
gtaaatttct agtttttctc cttcattttc ttggttagga cccttttctc tttttatttt       60

tttgagcttt gatctttctt taaactgatc tattttttaa ttgattggtt atggtgtaaa      120

tattacatag ctttaactga taatctgatt actttatttc gtgtgtctat gatgatgatg      180

atagttacag                                                             190


<210>  40637
<211>  271
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40637
gtaagtaccg cctatagagt ctataggccc acccccttgg cttcttatgc atgctatact       60

gtttttggct tggggtctat acacccccgc ttcctcatgt tataggtgat ggtatagctt      120

agcctatagg tgtgggttat tgaccattat tgaccactcc aacggtggag ggcagtgtag      180

tctgagcagt actcgttgct gccgcgcgcg ccaccagaca taatagctga cagactaaca      240

gactgttcct ttccatgggt cttttctgca g                                     271


<210>  40638
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40638
gtaagtaccg cctatagact ctataggcac acccctttgg ctcttatgca tgctgacaga       60

ctaacagact gttcctttcc tgggtctttt ctgcag                                 96


<210>  40639
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40639
gtaagtaccg cctatagact ctataggcac acccctttgg ctcttatgca tgaattaata       60

cgactcacta tagggagaca gactgttcct ttcctgggtc ttttctgcag                 110


<210>  40640
<211>  270
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40640
gtaagtaccg cctatagact ctataggcac acccctttgg ctcttatgca tgctatactg       60

tttttggctt ggggcctata cacccccgct tccttatgct ataggtgatg gtatagctta      120

gcctataggt gtgggttatt gaccattatt gaccactcca acggtggagg gcagtgtagt      180

ctgagcagta ctcgttgctg ccgcgcgcgc caccagacat aatagctgac agactaacag      240

actgttcctt tccatgggtc ttttctgcag                                       270


<210>  40641
<211>  116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40641
gtaagtactt tgctacatcc atactccatc cttcccatcc cttattcctt tgaacctttc       60

agttcgagct ttcccacttc atcgcagctt gactaacagc taccccgctt gagcag          116


<210>  40642
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40642
gtaggttcaa ccactgatgc ctaggcacac cgaaacgact aaccctaatt cttatccttt       60

acttcag                                                                 67


<210>  40643
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  casX intron sequence

<400>  40643
gtaaatataa aatttttaag tgtataatgt gttaaactac tgattctaat tgtttgtgta       60

ttttag                                                                  66


<210>  40644
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' ITR

<400>  40644
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  40645
<211>  584
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enhancer + core promoter

<400>  40645
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      540

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agct                       584


<210>  40646
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enhancer + core promoter

<400>  40646
gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      180

tgggaggtct atataagcag agct                                             204


<210>  40647
<211>  414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enhancer + core promoter

<400>  40647
aagatgcgtc aattaatttg cgtcaatttg cgctcaattt gcgtcaatct tgctgtcatt       60

tgcgtcaatt tgcgtcaata tgcgtcaata tatgcgtcaa ttcgaattcg cactaatgat      120

gactaatggt ggctaatggt gactaatggt gacaatgcgt gactaatggt gataatgagt      180

gcatatggtg actaatggtg actaatggtg gtgatgcggt tttggcagta catcaatggg      240

cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg      300

agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca      360

ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag agct            414


<210>  40648
<211>  314
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enhancer + core promoter

<400>  40648
tgggacagaa aacgagaaac cagggttgtc agcggggccc gcgccggccg ccccttggcc       60

cgcgggatac cccgggcgcc cagtgcccag gccgggcagg cggcactcac gtgatgcggt      120

tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc      180

accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat      240

gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct      300

atataagcag agct                                                        314


<210>  40649
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enhancer + core promoter

<400>  40649
cggaagcgag ggtgtcgctc gcccccgggc ccgggtccgc cccgctccga ggcctgctcg       60

gaagaaagac ctcggtgcgc agttctcgtc gcgctcccac acctggtccg cccagtcgga      120

gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt      180

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      240

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      300

tgggaggtct atataagcag agct                                             324


<210>  40650
<211>  304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enhancer + core promoter

<400>  40650
aggcgggccg ggagcgaggg aggcggcgcc gggggacgcg ccgggctcgg cctggcgacc       60

gttgcccgct cgcgtccatc catccattca ttcgggcggc gtgatgcggt tttggcagta      120

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      180

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      240

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      300

agct                                                                   304


<210>  40651
<211>  364
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enhancer + core promoter

<400>  40651
gccggggtac cgagctgggg ggcgggagct gtcccgggga caggcctggg tgaggctgcc       60

gggacgcagg gcccggctgg ggctacggcc gaggccacac ctggggctgt ctcgggctgt      120

ccaccctggg ggcggtgggc tgccatcccc caatctgtca gtgatgcggt tttggcagta      180

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      240

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      300

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      360

agct                                                                   364


<210>  40652
<211>  274
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enhancer + core promoter

<400>  40652
ccttcccctc cagtgctcct cggagccctt ccctatactt cctccaagct ccaccctcga       60

tcagccctgc gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc      120

acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa      180

tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag      240

gcgtgtacgg tgggaggtct atataagcag agct                                  274


<210>  40653
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enhancer + core promoter

<400>  40653
agaggtggtg gggctgagcc gaggtggggc cgtggccagg gggagggggt gctaggccgg       60

aaggggctgc agccgagggt ggccctgatt ttgtggccgg ccaggagcga aggggtccct      120

ttctgtcccc tgagcaccgt cgcctccttt gtgatgcggt tttggcagta catcaatggg      180

cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg      240

agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca      300

ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag agct            354


<210>  40654
<211>  584
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40654
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      540

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agct                       584


<210>  40655
<211>  400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40655
ggcctccgcg ccgggttttg gcgcctcccg cgggcgcccc cctcctcacg gcgagcgctg       60

ccacgtcaga cgaagggcgc agcgagcgtc ctgatccttc cgcccggacg ctcaggacag      120

cggcccgctg ctcataagac tcggccttag aaccccagta tcagcagaag gacattttag      180

gacgggactt gggtgactct agggcactgg ttttctttcc agagagcgga acaggcgagg      240

aaaagtagtc ccttctcggc gattctgcgg agggatctcc gtggggcggt gaacgccgat      300

gattatataa ggacgcgccg ggtgtggcac agctagttcc gtcgcagccg ggatttgggt      360

cgcggttctt gtttgtggat cgctgtgatc gtcacttggt                            400


<210>  40656
<211>  234
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40656
tggctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg agaagttggg       60

gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa actgggaaag      120

tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt atataagtgc      180

agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac aggt            234


<210>  40657
<211>  335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40657
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catgagaggg tatataatgg aagctcgact tccag                                 335


<210>  40658
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40658
ccaaaatcaa cgggactttc caaaatgtcg taataacccc gccccgttga cgcaaatggg       60

cggtaggcgt gtacggtggg aggtctatat aagcagagct                            100


<210>  40659
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40659
gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag ct               52


<210>  40660
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40660
ggtaggcgtg tacggtggga ggtctatata agcagagct                              39


<210>  40661
<211>  146
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40661
atgacacaaa ccccgcccag cgtcttgtca ttggcgaatt cgaacacgca gatgcagtcg       60

gggcggcgcg gtcccaggtc cacttcgcat attaaggtga cgcgtgtggc ctcgaacacc      120

gagcgaccct gcagcgaccc gcttaa                                           146


<210>  40662
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40662
ttcgcatatt aaggtgacgc gtgtggcctc gaacaccgag cgaccctgca gcgacccgct       60

taa                                                                     63


<210>  40663
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40663
cattttgaca cccccataat atttttccag aattaacagt ataaattgca tctcttgttc       60

aagagttccc tatcactctc tttaatcact actcacagta acctcaactc ctgc            114


<210>  40664
<211>  703
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40664
actagtttca tcaccaccgc cacccccccg cccccccgcc atctgaaagg gttctagggg       60

atttgcaacc tctctcgtgt gtttcttctt tccgagaagc gccgccacac gagaaagctg      120

gccgcgaaag tcgtgctgga atcacttcca acgaaacccc aggcatagat gggaaagggt      180

gaagaacacg ttgccatggc taccgtttcc ccggtcacgg aataaacgct ctctaggatc      240

cggaagtagt tccgccgcga cctctctaaa aggatggatg tgttctctgc ttacattcat      300

tggacgtttt cccttagagg ccaaggccgc ccaggcaaag gggcggtccc acgcgtgagg      360

ggcccgcgga gccatttgat tggagaaaag ctgcaaaccc tgaccaatcg gaaggagcca      420

cgcttcgggc atcggtcacc gcacctggac agctccgatt ggtggacttc cgccccccct      480

cacgaatcct cattgggtgc cgtgggtgcg tggtgcggcg cgattggtgg gttcatgttt      540

cccgtccccc gcccgcgaga agtgggggtg aaaagcggcc cgacctgctt ggggtgtagt      600

gggcggaccg cgcggctgga ggtgtgagga tccgaaccca ggggtggggg gtggaggcgg      660

ctcctgcgat cgaaggggac ttgagactca ccggccgcac gtc                        703


<210>  40665
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40665
gtacttatat aagggggtgg gggcgcgttc gtcctcagtc gcgatcgaac actcgagccg       60

agcagacgtg cctacggacc g                                                 81


<210>  40666
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40666
aggtctatat aagcagagct cgtttagtga accgtcagat cgcctggaga cgtcgagccg       60

agtggttgtg cctccataga a                                                 81


<210>  40667
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40667
aggtctatat aagcagagct cgtttagtga accgtcagtc cgcctggaga cctgcagccg       60

agtggtcgtg cctccataga a                                                 81


<210>  40668
<211>  229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40668
agctgaatgg ggtccgcctc ttttccctgc ctaaacagac aggaactcct gccaattgag       60

ggcgtcaccg ctaaggctcc gccccagcct gggctccaca accaatgaag ggtaatctcg      120

acaaagagca aggggtgggg cgcgggcgcg caggtgcagc agcacacagg ctggtcggga      180

gggcggggcg cgacgtctgc cgtgcggggt cccggcatcg gttgcgcgc                  229


<210>  40669
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40669
ggtaggcgtg tacggtggga ggcctatata agcagagctc gtttagtgaa ccgtcagatc       60

gcctggag                                                                68


<210>  40670
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40670
aggtctatat aagcagagct ctctggctaa ctagagaacc cactgcttaa ctggcttatc       60

gaaat                                                                   65


<210>  40671
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40671
ggtaggcgtg tacggtggga ggtctatata agcagagct                              39


<210>  40672
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40672
ggggctataa aagggggtgg gggcgcgttc gtcctcactc tcttccgcat cgctgtctgc       60

gagggccagc tgttggggtg a                                                 81


<210>  40673
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40673
gggggaggag attaggttaa aggtctttgt attaggaggc tgtaggcata aattggtctg       60

ttcaccagca ccatgcaact ttttcacctc tgcctaatca tctcatg                    107


<210>  40674
<211>  227
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40674
tgtagtctta tgcaatactc ttgtagtctt gcaacatggt aacgatgagt tagcaacatg       60

ccttacaagg agagaaaaag caccgtgcat gccgattggt ggaagtaagg tggtacgatc      120

gtgccttatt aggaaggcaa cagacgggtc tgacatggat tggacgaacc actgaattgc      180

cgcattgcag agatattgta tttaagtgcc tagctcgata cataaac                    227


<210>  40675
<211>  448
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40675
agtgcaagtg ggttttagga ccaggatgag gcggggtggg ggtgcctacc tgacgaccga       60

ccccgaccca ctggacaagc acccaacccc cattccccaa attgcgcatc ccctatcaga      120

gagggggagg ggaaacagga tgcggcgagg cgcgtgcgca ctgccagctt cagcaccgcg      180

gacagtgcct tcgcccccgc ctggcggcgc gcgccaccgc cgcctcagca ctgaaggcgc      240

gctgacgtca ctcgccggtc ccccgcaaac tccccttccc ggccaccttg gtcgcgtccg      300

cgccgccgcc ggcccagccg gaccgcacca cgcgaggcgc gagatagggg ggcacgggcg      360

cgaccatctg cgctgcggcg ccggcgactc agcgctgcct cagtctgcgg tgggcagcgg      420

aggagtcgtg tcgtgcctga gagcgcag                                         448


<210>  40676
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40676
gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc       60

atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga      120

agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc      180

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt      240

tttatttatg cagaggccga ggccgcctcg gcctctgagc tattccagaa gtagtgagga      300

ggcttttttg gaggcctagg cttttgcaaa                                       330


<210>  40677
<211>  511
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40677
ggggttgggg ttgcgccttt tccaaggcag ccctgggttt gcgcagggac gcggctgctc       60

tgggcgtggt tccgggaaac gcagcggcgc cgaccctggg tctcgcacat tcttcacgtc      120

cgttcgcagc gtcacccgga tcttcgccgc tacccttgtg ggccccccgg cgacgcttcc      180

tgctccgccc ctaagtcggg aaggttcctt gcggttcgcg gcgtgccgga cgtgacaaac      240

ggaagccgca cgtctcacta gtaccctcgc agacggacag cgccagggag caatggcagc      300

gcgccgaccg cgatgggctg tggccaatag cggctgctca gcagggcgcg ccgagagcag      360

cggccgggaa ggggcggtgc gggaggcggg gtgtggggcg gtagtgtggg ccctgttcct      420

gcccgcgcgg tgttccgcat tctgcaagcc tccggagcgc acgtcggcag tcggctccct      480

cgttgaccga atcaccgacc tctctcccca g                                     511


<210>  40678
<211>  164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40678
gggcggagtt agggcggagc caatcagcgt gcgccgttcc gaaagttgcc ttttatggct       60

gggcggagaa tgggcggtga acgccgatga ttatataagg acgcgccggg tgtggcacag      120

ctagttccgt cgcagccggg atttgggtcg cggttcttgt ttgt                       164


<210>  40679
<211>  326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40679
gggcggagtt agggcggagc caatcagcgt gcgccgttcc gaaagttgcc ttttatggct       60

gggcggagaa tgggcggtga acgccgatga ttatataagg acgcgccggg tgtggcacag      120

ctagttccgt cgcagccggg atttgggtcg cggttcttgt ttgtggatcc ctgtgatcgt      180

cacttggtaa gtcactgact gtctatgcct gggaaagggt gggcaggaga tggggcagtg      240

caggaaaagt ggcactatga accctgcagc cctaggaatg catctagaca attgtactaa      300

ccttcttctc tttcctctcc tgacag                                           326


<210>  40680
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40680
ccccgcagcc attctagcta gcggtaccaa tagcaaccgg cagctgccct ccgcttttgc       60

tccgcccctt ctgcttgcga tctgtttccg cttccggtcc cgcagttccg gctctgccgt      120

gaagagcttt gcattgtggg aagtctttcc tttctcgttc cccggccatc ttagcggctg      180

ctgttggtga gtgggctcct accgaccgag gtttaggcag cgcggggagc tttgcgggtt      240

gccatttgta actccggatc ctaaaattcc tgtcctgttc tctgtctctt ctaggttggg      300

ggccgtcccg ctcctaaggc aggaa                                            325


<210>  40681
<211>  243
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40681
agccccggaa ccttcgctgt tctcttacct atgaacctta cgaactgtaa agaaaggcgc       60

accggaagtt gtggtaccca agccatactc tcataaatcc agccaggtcg cgctgaaaca      120

gtttccggaa gcacttctcc tagatcgcac cgcctcttcc tcctggaagc tatataatga      180

tatcgcgtca cttccgctct ctcttccaca ggaggcctac acgccgccgc ttgtgctgca      240

gcc                                                                    243


<210>  40682
<211>  493
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40682
ccacgttctg cttcactctc cccatctccc ccccctcccc acccccaatt ttgtatttat       60

ttatttttta attattttgt gcagcgatgg gggcgggggg gggggggggg cgcgcgccag      120

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      180

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      240

ataaaaagcg aagcgcgcgg cgggcgggag cgggatcagc caccgcggtg gcggcctaga      300

gtcgacgagg aactgaaaaa ccagaaagtt aactggtaag tttagtcttt ttgtctttta      360

tttcaggtcc cggatccggt ggtggtgcaa atcaaagaac tgctcctcag tggatgttgc      420

ctttacttct aggcctgtac ggaagtgtta cttctgctct aaaagctgcg gaattgtacc      480

cgcggccgat cca                                                         493


<210>  40683
<211>  565
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40683
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg      120

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga      180

cgtcaatgac ggtaaatggc ccgcctggca ttgtgcccag tacatgacct tatgggactt      240

tcctacttgg cagtacatct acgtattagt catcgctatt accatggtcg aggtgagccc      300

cacgttctgc ttcactctcc ccatctcccc cccctcccca cccccaattt tgtatttatt      360

tattttttaa ttattttgtg cagcgatggg ggcggggggg gggggggggc gcgcgccagg      420

cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa      480

tcagagcggc gcgctccgaa agtttccttt tatggcgagg cggcggcggc ggcggcccta      540

taaaaagcga agcgcgcggc gggcg                                            565


<210>  40684
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protein promoter

<400>  40684
gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      180

tgggaggtct atataagcag agct                                             204


<210>  40685
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40685

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg 
1               5                   10      


<210>  40686
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40686

Met Ala Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Gly Ser 
            20                  25                  30          


Pro Lys Lys Lys Arg Lys Val Ser Arg 
        35                  40      


<210>  40687
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40687

Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg 
1               5                   10      


<210>  40688
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40688

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys 
1               5                   10                  15      


Arg Val Lys Leu Asp Ser Arg 
            20              


<210>  40689
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40689

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys 
1               5                   10                  15      


Arg Val Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys Arg Val Lys Leu 
            20                  25                  30          


Asp Gly Gly Ser Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg 
        35                  40                  45          


<210>  40690
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40690

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys 
1               5                   10                  15      


Arg Val Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys Arg Val Lys Leu 
            20                  25                  30          


Asp Gly Gly Ser Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser 
        35                  40                  45              


Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys 
    50                  55                  60                  


Arg Val Lys Leu Asp Ser Arg 
65                  70      


<210>  40691
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40691

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


Ser Arg 
        


<210>  40692
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40692

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


Gly Gly Ser Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys 
            20                  25                  30          


Lys Lys Lys Ser Arg 
        35          


<210>  40693
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40693

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Arg 
            20      


<210>  40694
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40694

Pro Ala Ala Lys Lys Lys Lys Leu Asp Gly Gly Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Arg 
            20      


<210>  40695
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40695

Pro Ala Ala Lys Lys Lys Lys Leu Asp Ser Arg 
1               5                   10      


<210>  40696
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40696

Pro Ala Ala Lys Lys Lys Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys 
1               5                   10                  15      


Lys Lys Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys Lys Lys Lys Leu 
            20                  25                  30          


Asp Ser Arg 
        35  


<210>  40697
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40697

Pro Ala Ala Lys Lys Lys Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys 
1               5                   10                  15      


Lys Lys Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys Lys Lys Lys Leu 
            20                  25                  30          


Asp Gly Gly Ser Pro Ala Ala Lys Lys Lys Lys Leu Asp Ser Arg 
        35                  40                  45          


<210>  40698
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40698

Pro Ala Lys Arg Ala Arg Arg Gly Tyr Lys Cys Ser Arg 
1               5                   10              


<210>  40699
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40699

Pro Ala Lys Arg Ala Arg Arg Gly Tyr Lys Cys Gly Ser Pro Ala Lys 
1               5                   10                  15      


Arg Ala Arg Arg Gly Tyr Lys Cys Ser Arg 
            20                  25      


<210>  40700
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40700

Pro Arg Arg Lys Arg Glu Glu Ser Arg 
1               5                   


<210>  40701
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40701

Pro Tyr Arg Gly Arg Lys Glu Ser Arg 
1               5                   


<210>  40702
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40702

Pro Leu Arg Lys Arg Pro Arg Arg Ser Arg 
1               5                   10  


<210>  40703
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40703

Pro Leu Arg Lys Arg Pro Arg Arg Gly Ser Pro Leu Arg Lys Arg Pro 
1               5                   10                  15      


Arg Arg Ser Arg 
            20  


<210>  40704
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40704

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Lys Arg Thr Ala Asp 
1               5                   10                  15      


Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg Lys Val Gly Gly Ser 
            20                  25                  30          


<210>  40705
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40705

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Lys Arg Thr Ala Asp 
1               5                   10                  15      


Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro 
            20                  25                  30          


Pro Gly 
        


<210>  40706
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40706

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Lys Arg Thr Ala Asp 
1               5                   10                  15      


Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg Lys Val Gly Ile His 
            20                  25                  30          


Gly Val Pro Ala Ala Pro Gly 
        35                  


<210>  40707
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40707

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Lys Arg Thr Ala Asp 
1               5                   10                  15      


Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg Lys Val Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Ser Pro Gly 
        35                  


<210>  40708
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40708

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Lys Arg Thr Ala Asp 
1               5                   10                  15      


Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg Lys Val Pro Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Ser Pro Gly 
        35                  40  


<210>  40709
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40709

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Lys Arg Thr Ala Asp 
1               5                   10                  15      


Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg Lys Val Ala Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Pro Gly 
        35                  40                  45              


<210>  40710
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40710

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Lys Arg Thr Ala Asp 
1               5                   10                  15      


Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg Lys Val Pro Gly 
            20                  25                  30      


<210>  40711
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40711

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Gly Gly Ser 
            20          


<210>  40712
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40712

Pro Ala Ala Lys Arg Val Lys Leu Asp Pro Pro Pro Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Pro Gly 
            20      


<210>  40713
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40713

Pro Ala Ala Lys Arg Val Lys Leu Asp Pro Gly 
1               5                   10      


<210>  40714
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40714

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Ser 
            20      


<210>  40715
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40715

Pro Ala Ala Lys Arg Val Lys Leu Asp Pro Pro Pro 
1               5                   10          


<210>  40716
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40716

Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Ser Pro Pro Pro 
            20                  


<210>  40717
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40717

Pro Lys Lys Lys Arg Lys Val Pro Pro Pro 
1               5                   10  


<210>  40718
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5' NLS aa sequence

<400>  40718

Pro Lys Lys Lys Arg Lys Val Gly Gly Ser 
1               5                   10  


<210>  40719
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40719

Gly Ser Pro Lys Lys Lys Arg Lys Val 
1               5                   


<210>  40720
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40720

Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Gly Ser 
            20                  25                  30          


Pro Lys Lys Lys Arg Lys Val 
        35                  


<210>  40721
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40721

Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Gly Ser 
            20                  25                  30          


Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Pro Lys Lys Lys Arg Lys 
        35                  40                  45              


Val Gly Gly Ser Pro Lys Lys Lys Arg Lys Val 
    50                  55                  


<210>  40722
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40722

Gly Ser Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   10      


<210>  40723
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40723

Gly Ser Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Ala 
1               5                   10                  15      


Ala Lys Arg Val Lys Leu Asp 
            20              


<210>  40724
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40724

Gly Ser Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Ala 
1               5                   10                  15      


Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys Arg Val 
            20                  25                  30          


Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys Arg Val Lys Leu Asp 
        35                  40                  45          


<210>  40725
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40725

Gly Ser Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Ala 
1               5                   10                  15      


Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys Arg Val 
            20                  25                  30          


Lys Leu Asp Gly Gly Ser Pro Ala Ala Lys Arg Val Lys Leu Asp Gly 
        35                  40                  45              


Gly Ser Pro Ala Ala Lys Arg Val Lys Leu Asp Gly Gly Ser Pro Ala 
    50                  55                  60                  


Ala Lys Arg Val Lys Leu Asp 
65                  70      


<210>  40726
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40726

Gly Ser Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys 
1               5                   10                  15      


Lys Lys 
        


<210>  40727
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40727

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


Gly Gly Ser Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys 
            20                  25                  30          


Lys Lys Lys 
        35  


<210>  40728
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40728

Gly Ser Pro Ala Ala Lys Arg Val Lys Leu Gly Gly Ser Pro Ala Ala 
1               5                   10                  15      


Lys Arg Val Lys Leu Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Gly 
            20                  25                  30          


Gly Ser Pro Lys Lys Lys Arg Lys Val 
        35                  40      


<210>  40729
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40729

Gly Ser Lys Leu Gly Pro Arg Lys Ala Thr Gly Arg Trp Gly Ser 
1               5                   10                  15  


<210>  40730
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40730

Gly Ser Lys Arg Lys Gly Ser Pro Glu Arg Gly Glu Arg Lys Arg His 
1               5                   10                  15      


Trp Gly Ser 
            


<210>  40731
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40731

Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Ser Gly Ser Lys Arg Pro 
1               5                   10                  15      


Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys Leu Glu 
            20                  25                  30      


<210>  40732
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40732

Gly Pro Lys Arg Thr Ala Asp Ser Gln His Ser Thr Pro Pro Lys Thr 
1               5                   10                  15      


Lys Arg Lys Val Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30  


<210>  40733
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40733

Gly Gly Gly Ser Gly Gly Gly Ser Lys Arg Thr Ala Asp Ser Gln His 
1               5                   10                  15      


Ser Thr Pro Pro Lys Thr Lys Arg Lys Val Glu Phe Glu Pro Lys Lys 
            20                  25                  30          


Lys Arg Lys Val 
        35      


<210>  40734
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40734

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Ala Lys Arg Thr Ala Asp Ser Gln His Ser Thr Pro Pro Lys Thr Lys 
            20                  25                  30          


Arg Lys Val Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
        35                  40                  45  


<210>  40735
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40735

Gly Pro Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Lys Arg Thr Ala 
1               5                   10                  15      


Asp Ser Gln His Ser Thr Pro Pro Lys Thr Lys Arg Lys Val Glu Phe 
            20                  25                  30          


Glu Pro Lys Lys Lys Arg Lys Val 
        35                  40  


<210>  40736
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40736

Gly Pro Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala 
1               5                   10                  15      


Ala Lys Ala Pro Ala Ala Lys Arg Val Lys Leu Asp 
            20                  25              


<210>  40737
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40737

Gly Pro Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Pro Ala 
1               5                   10                  15      


Ala Lys Arg Val Lys Leu Asp 
            20              


<210>  40738
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40738

Gly Pro Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Ala Ala Lys 
1               5                   10                  15      


Arg Val Lys Leu Asp 
            20      


<210>  40739
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40739

Gly Pro Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   10      


<210>  40740
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40740

Thr Gly Gly Gly Pro Gly Gly Gly Ala Ala Ala Gly Ser Gly Ser Pro 
1               5                   10                  15      


Lys Lys Lys Arg Lys Val Gly Ser Gly Ser Lys Arg Pro Ala Ala Thr 
            20                  25                  30          


Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys Leu Glu 
        35                  40                  


<210>  40741
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40741

Thr Gly Gly Gly Pro Gly Gly Gly Ala Ala Ala Gly Ser Gly Ser Pro 
1               5                   10                  15      


Lys Lys Lys Arg Lys Val Gly Ser Gly Ser 
            20                  25      


<210>  40742
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40742

Pro Pro Pro Pro Lys Lys Lys Arg Lys Val Pro Pro Pro 
1               5                   10              


<210>  40743
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40743

Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro 
1               5                   10              


<210>  40744
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40744

Pro Pro Pro Pro Lys Lys Lys Arg Lys Val 
1               5                   10  


<210>  40745
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40745

Gly Gly Ser Pro Lys Lys Lys Arg Lys Val 
1               5                   10  


<210>  40746
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40746

Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Gly Gly Ser 
1               5                   10                  15      


Gly Gly Ser 
            


<210>  40747
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40747

Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Pro Lys Lys 
1               5                   10                  15      


Lys Arg Lys Val 
            20  


<210>  40748
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40748

Gly Gly Ser Gly Gly Ser Gly Gly Ser Pro Lys Lys Lys Arg Lys Val 
1               5                   10                  15      


Gly Gly Ser Pro Lys Lys Lys Arg Lys Val 
            20                  25      


<210>  40749
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40749

Pro Pro Pro Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Pro 
1               5                   10                  15      


Ala Ala Lys Arg Val Lys Leu Asp 
            20                  


<210>  40750
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40750

Pro Pro Pro Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   10          


<210>  40751
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3' NLS aa sequence

<400>  40751

Pro Pro Pro Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Pro 
1               5                   10                  15      


Ala Ala Lys Arg Val Lys Leu Asp 
            20                  


<210>  40752
<211>  592
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTRE

<400>  40752
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaagctga cgtcctttcc atggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgcc tg              592


<210>  40753
<211>  593
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTRE

<400>  40753
atcgataatc aacctctgga ttacaaaatt tgtgaaagat tgactggtat tcttaactat       60

gttgctcctt ttacgctatg tggatacgct gctttaatgc ctttgtatca tgctattgct      120

tcccgtatgg ctttcatttt ctcctccttg tataaatcct ggttgctgtc tctttatgag      180

gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc tgacgcaacc      240

cccactggtt ggggcattgc caccacctgt cagctccttt ccgggacttt cgctttcccc      300

ctccctattg ccacggcgga actcatcgcc gcctgccttg cccgctgctg gacaggggct      360

cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga aatcatcgtc ctttccttgg      420

ctgctcgcct gtgttgccac ctggattctg cgcgggacgt ccttctgcta cgtcccttcg      480

gccctcaatc cagcggacct tccttcccgc ggcctgctgc cggctctgcg gcctcttccg      540

cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt gggccgcctc ccc             593


<210>  40754
<211>  247
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTRE

<400>  40754
gataatcaac ctctggatta caaaatttgt gaaagattga ctggtattct taactatgtt       60

gctcctttta cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc tattgcttcc      120

cgtatggctt tcattttctc ctccttgtat aaatcctggt tagttcttgc cacggcggaa      180

ctcatcgccg cctgccttgc ccgctgctgg acaggggctc ggctgttggg cactgacaat      240

tccgtgg                                                                247


<210>  40755
<211>  208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly A signal

<400>  40755
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagagaa tagcaggcat gctgggga                                         208


<210>  40756
<211>  623
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly A signal

<400>  40756
gggtggcatc cctgtgaccc ctccccagtg cctctcctgg ccctggaagt tgccactcca       60

gtgcccacca gccttgtcct aataaaatta agttgcatca ttttgtctga ctaggtgtcc      120

ttctataata ttatggggtg gaggggggtg gtatggagca aggggcaagt tgggaagaca      180

acctgtaggg cctgcggggt ctattgggaa ccaagctgga gtgcagtggc acaatcttgg      240

ctcactgcaa tctccgcctc ctgggttcaa gcgattctcc tgcctcagcc tcccgagttg      300

ttgggattcc aggcatgcat gaccaggctc agctaatttt tgtttttttg gtagagacgg      360

ggtttcacca tattggccag gctggtctcc aactcctaat ctcaggtgat ctacccacct      420

tggcctccca aattgctggg attacaggcg tgaaccactg ctcccttccc tgtccttctg      480

attttaaaat aactatacca gcaggaggac gtccagacac agcataggct acctggccat      540

gcccaaccgg tgggacattt gagttgcttg cttggcactg tcctctcatg cgttgggtcc      600

actcagtaga tgcctgttga att                                              623


<210>  40757
<211>  477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly A signal

<400>  40757
gggtggcatc cctgtgaccc ctccccagtg cctctcctgg ccctggaagt tgccactcca       60

gtgcccacca gccttgtcct aataaaatta agttgcatca ttttgtctga ctaggtgtcc      120

ttctataata ttatggggtg gaggggggtg gtatggagca aggggcaagt tgggaagaca      180

acctgtaggg cctgcggggt ctattgggaa ccaagctgga gtgcagtggc acaatcttgg      240

ctcactgcaa tctccgcctc ctgggttcaa gcgattctcc tgcctcagcc tcccgagttg      300

ttgggattcc aggcatgcat gaccaggctc agctaatttt tgtttttttg gtagagacgg      360

ggtttcacca tattggccag gctggtctcc aactcctaat ctcaggtgat ctacccacct      420

tggcctccca aattgctggg attacaggcg tgaaccactg ctcccttccc tgtcctt         477


<210>  40758
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly A signal

<400>  40758
cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttc                   49


<210>  40759
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly A signal

<400>  40759
aataaaagat ctttattttc attagatctg tgtgttggtt ttttgtgtg                   49


<210>  40760
<211>  122
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly A signal

<400>  40760
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct      120

ta                                                                     122


<210>  40761
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly A signal

<400>  40761
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcact gc                                                82


<210>  40762
<211>  395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly A signal

<400>  40762
gctcgctttc ttgctgtcca atttctatta aaggttcctt tgttccctaa gtccaactac       60

taaactgggg gatattatga agggccttga gcatctggat tctgcctaat aaaaaacatt      120

tattttcatt gcaatgatgt atttaaatta tttctgaata ttttactaaa aagggaatgt      180

gggaggtcag tgcatttaaa acataaagaa atgaagagct agttcaaacc ttgggaaaat      240

acactatatc ttaaactcca tgaaagaagg tgaggctgca aacagctaat gcacattggc      300

aacagcccct gatgcctatg ccttattcat ccctcagaaa aggattcaag tagaggcttg      360

atttggaggt taaagttttg ctatgctgta tttta                                 395


<210>  40763
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly A signal

<400>  40763
aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt ctctca           56


<210>  40764
<211>  181
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly A signal

<400>  40764
tatttgtgaa atttgtgatg ctattgcttt atttgtaacc atctagcttt atttgtgaaa       60

tttgtgatgc tattgcttta tttgtaacca ttataagctg caataaacaa gttaacaaca      120

acaattgcat tcattttatg tttcaggttc agggggagat gtgggaggtt ttttaaagcg      180

g                                                                      181


<210>  40765
<211>  241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA promoter

<400>  40765
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

c                                                                      241


<210>  40766
<211>  215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA promoter

<400>  40766
gaacgctgac gtcatcaacc cgctccaagg aatcgcgggc ccagtgtcac taggcgggaa       60

cacccagcgc gcgtgcgccc tggcaggaag atggctgtga gggacagggg agtggcgccc      120

tgcaatattt gcatgtcgct atgtgttctg ggaaatcacc ataaacgtga aatgtctttg      180

gatttgggaa tcttataagt tctgtatgag accac                                 215


<210>  40767
<211>  244
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA promoter

<400>  40767
ctgcagtatt tagcatgccc cacccatctg caaggcattc tggatagtgt caaaacagcc       60

ggaaatcaag tccgtttatc tcaaacttta gcattttggg aataaatgat atttgctatg      120

ctggttaaat tagattttag ttaaatttcc tgctgaagct ctagtacgat aagtaacttg      180

acctaagtgt aaagttgaga tttccttcag gtttatatag cttgtgcgcc gcctgggtac      240

ctcg                                                                   244


<210>  40768
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA promoter

<400>  40768
gagggcctat ttcccatgat tccttcatat ttgcatatac gatagcttac cgtaacttga       60

aagtatttcg atttcttggc tttatatatc ttgtggaaag gac                        103


<210>  40769
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA promoter

<400>  40769
tttcgatttc ttggctttat atatcttgtg gaaaggac                               38


<210>  40770
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA promoter

<400>  40770
atacgatagc ttaccgtaac ttgaaagtat ttcgatttct tggctttata tatcttgtgg       60

aaaggac                                                                 67


<210>  40771
<211>  79
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA promoter

<400>  40771
gagggcctat ttcccatgat tccttcatat ttgcattttc gatttcttgg ctttatatat       60

cttgtggaaa ggacgaaac                                                    79


<210>  40772
<211>  111
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA promoter

<400>  40772
gagggcctat ttcccatgat tccttcatat ttgcatattt gcatatacga tagcttaccg       60

taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga c               111


<210>  40773
<211>  127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA promoter

<400>  40773
gagggcctat ttcccatgat tccttcatat ttgcatattt gcatatttgc atatttgcat       60

atacgatagc ttaccgtaac ttgaaagtat ttcgatttct tggctttata tatcttgtgg      120

aaaggac                                                                127


<210>  40774
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA promoter

<400>  40774
gagggcctat ttcccatgat tccttcatat ttcccatgat tccttcatat ttgcatatac       60

gatagcttac cgtaacttga aagtatttcg atttcttggc tttatatatc ttgtggaaag      120

gac                                                                    123


<210>  40775
<211>  143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA promoter

<400>  40775
gagggcctat ttcccatgat tccttcatat ttcccatgat tccttcatat ttcccatgat       60

tccttcatat ttgcatatac gatagcttac cgtaacttga aagtatttcg atttcttggc      120

tttatatatc ttgtggaaag gac                                              143


<210>  40776
<211>  131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA promoter

<400>  40776
gagggcctat ttcccatgat tccttcatat ttgcatattt cccatgattc cttcatattt       60

gcatatacga tagcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt      120

gtggaaagga c                                                           131


<210>  40777
<211>  159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA promoter

<400>  40777
gagggcctat ttcccatgat tccttcatat ttgcatattt cccatgattc cttcatattt       60

gcatatttcc catgattcct tcatatttgc atatacgata gcttaccgta acttgaaagt      120

atttcgattt cttggcttta tatatcttgt ggaaaggac                             159


<210>  40778
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA promoter

<400>  40778
gagggcctat ttcccatgat tccttcatat gcaaatatac gatagcttac cgtaacttga       60

aagtatttcg atttcttggc tttatatatc ttgtggaaag gac                        103


<210>  40779
<211>  111
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA promoter

<400>  40779
gagggcctat ttcccatgat tccttcatat gcaaatatgc aaatatacga tagcttaccg       60

taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga c               111


<210>  40780
<211>  127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA promoter

<400>  40780
gagggcctat ttcccatgat tccttcatat gcaaatatgc aaatatgcaa atatgcaaat       60

atacgatagc ttaccgtaac ttgaaagtat ttcgatttct tggctttata tatcttgtgg      120

aaaggac                                                                127


<210>  40781
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA promoter

<400>  40781
gagggcctat gcaaatatga aggaatcatg ggaaatatac gatagcttac cgtaacttga       60

aagtatttcg atttcttggc tttatatatc ttgtggaaag gac                        103


<210>  40782
<211>  131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA promoter

<400>  40782
gagggcctat gcaaatatga aggaatcatg ggaaatatgc aaatatgaag gaatcatggg       60

aaatatacga tagcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt      120

gtggaaagga c                                                           131


<210>  40783
<211>  159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA promoter

<400>  40783
gagggcctat gcaaatatga aggaatcatg ggaaatatgc aaatatgaag gaatcatggg       60

aaatatgcaa atatgaagga atcatgggaa atatacgata gcttaccgta acttgaaagt      120

atttcgattt cttggcttta tatatcttgt ggaaaggac                             159


<210>  40784
<211>  128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA promoter

<400>  40784
gagggcctat ttcccatgat tccttcatat ttgcatatac gtttgactgt aaatacgtga       60

cgtagaatag cttaccgtaa cttgaaagta tttcgatttc ttggctttat atatcttgtg      120

gaaaggac                                                               128


<210>  40785
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' ITR

<400>  40785
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag ctgcctgcag g                                                141


<210>  40786
<211>  4
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3' ITR

<400>  40786
aaag                                                                     4


<210>  40787
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3' ITR

<400>  40787
uuuuuaaa                                                                 8


<210>  40788
<211>  4
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3' ITR

<400>  40788
gaaa                                                                     4


<210>  40789
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracr cRNA linker

<400>  40789
gagaaa                                                                   6


<210>  40790
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplant transit peptide

<400>  40790

Met Ala Ser Met Ile Ser Ser Ser Ala Val Thr Thr Val Ser Arg Ala 
1               5                   10                  15      


Ser Arg Gly Gln Ser Ala Ala Met Ala Pro Phe Gly Gly Leu Lys Ser 
            20                  25                  30          


Met Thr Gly Phe Pro Val Arg Lys Val Asn Thr Asp Ile Thr Ser Ile 
        35                  40                  45              


Thr Ser Asn Gly Gly Arg Val Lys Cys Met Gln Val Trp Pro Pro Ile 
    50                  55                  60                  


Gly Lys Lys Lys Phe Glu Thr Leu Ser Tyr Leu Pro Pro Leu Thr Arg 
65                  70                  75                  80  


Asp Ser Arg Ala 
                


<210>  40791
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplant transit peptide

<400>  40791

Met Ala Ser Met Ile Ser Ser Ser Ala Val Thr Thr Val Ser Arg Ala 
1               5                   10                  15      


Ser Arg Gly Gln Ser Ala Ala Met Ala Pro Phe Gly Gly Leu Lys Ser 
            20                  25                  30          


Met Thr Gly Phe Pro Val Arg Lys Val Asn Thr Asp Ile Thr Ser Ile 
        35                  40                  45              


Thr Ser Asn Gly Gly Arg Val Lys Ser 
    50                  55          


<210>  40792
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplant transit peptide

<400>  40792

Met Ala Ser Ser Met Leu Ser Ser Ala Thr Met Val Ala Ser Pro Ala 
1               5                   10                  15      


Gln Ala Thr Met Val Ala Pro Phe Asn Gly Leu Lys Ser Ser Ala Ala 
            20                  25                  30          


Phe Pro Ala Thr Arg Lys Ala Asn Asn Asp Ile Thr Ser Ile Thr Ser 
        35                  40                  45              


Asn Gly Gly Arg Val Asn Cys Met Gln Val Trp Pro Pro Ile Glu Lys 
    50                  55                  60                  


Lys Lys Phe Glu Thr Leu Ser Tyr Leu Pro Asp Leu Thr Asp Ser Gly 
65                  70                  75                  80  


Gly Arg Val Asn Cys 
                85  


<210>  40793
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplant transit peptide

<400>  40793

Met Ala Gln Val Ser Arg Ile Cys Asn Gly Val Gln Asn Pro Ser Leu 
1               5                   10                  15      


Ile Ser Asn Leu Ser Lys Ser Ser Gln Arg Lys Ser Pro Leu Ser Val 
            20                  25                  30          


Ser Leu Lys Thr Gln Gln His Pro Arg Ala Tyr Pro Ile Ser Ser Ser 
        35                  40                  45              


Trp Gly Leu Lys Lys Ser Gly Met Thr Leu Ile Gly Ser Glu Leu Arg 
    50                  55                  60                  


Pro Leu Lys Val Met Ser Ser Val Ser Thr Ala Cys 
65                  70                  75      


<210>  40794
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplant transit peptide

<400>  40794

Met Ala Gln Val Ser Arg Ile Cys Asn Gly Val Trp Asn Pro Ser Leu 
1               5                   10                  15      


Ile Ser Asn Leu Ser Lys Ser Ser Gln Arg Lys Ser Pro Leu Ser Val 
            20                  25                  30          


Ser Leu Lys Thr Gln Gln His Pro Arg Ala Tyr Pro Ile Ser Ser Ser 
        35                  40                  45              


Trp Gly Leu Lys Lys Ser Gly Met Thr Leu Ile Gly Ser Glu Leu Arg 
    50                  55                  60                  


Pro Leu Lys Val Met Ser Ser Val Ser Thr Ala Cys 
65                  70                  75      


<210>  40795
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplant transit peptide

<400>  40795

Met Ala Gln Ile Asn Asn Met Ala Gln Gly Ile Gln Thr Leu Asn Pro 
1               5                   10                  15      


Asn Ser Asn Phe His Lys Pro Gln Val Pro Lys Ser Ser Ser Phe Leu 
            20                  25                  30          


Val Phe Gly Ser Lys Lys Leu Lys Asn Ser Ala Asn Ser Met Leu Val 
        35                  40                  45              


Leu Lys Lys Asp Ser Ile Phe Met Gln Leu Phe Cys Ser Phe Arg Ile 
    50                  55                  60                  


Ser Ala Ser Val Ala Thr Ala Cys 
65                  70          


<210>  40796
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplant transit peptide

<400>  40796

Met Ala Ala Leu Val Thr Ser Gln Leu Ala Thr Ser Gly Thr Val Leu 
1               5                   10                  15      


Ser Val Thr Asp Arg Phe Arg Arg Pro Gly Phe Gln Gly Leu Arg Pro 
            20                  25                  30          


Arg Asn Pro Ala Asp Ala Ala Leu Gly Met Arg Thr Val Gly Ala Ser 
        35                  40                  45              


Ala Ala Pro Lys Gln Ser Arg Lys Pro His Arg Phe Asp Arg Arg Cys 
    50                  55                  60                  


Leu Ser Met Val Val 
65                  


<210>  40797
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplant transit peptide

<400>  40797

Met Ala Ala Leu Thr Thr Ser Gln Leu Ala Thr Ser Ala Thr Gly Phe 
1               5                   10                  15      


Gly Ile Ala Asp Arg Ser Ala Pro Ser Ser Leu Leu Arg His Gly Phe 
            20                  25                  30          


Gln Gly Leu Lys Pro Arg Ser Pro Ala Gly Gly Asp Ala Thr Ser Leu 
        35                  40                  45              


Ser Val Thr Thr Ser Ala Arg Ala Thr Pro Lys Gln Gln Arg Ser Val 
    50                  55                  60                  


Gln Arg Gly Ser Arg Arg Phe Pro Ser Val Val Val Cys 
65                  70                  75          


<210>  40798
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplant transit peptide

<400>  40798

Met Ala Ser Ser Val Leu Ser Ser Ala Ala Val Ala Thr Arg Ser Asn 
1               5                   10                  15      


Val Ala Gln Ala Asn Met Val Ala Pro Phe Thr Gly Leu Lys Ser Ala 
            20                  25                  30          


Ala Ser Phe Pro Val Ser Arg Lys Gln Asn Leu Asp Ile Thr Ser Ile 
        35                  40                  45              


Ala Ser Asn Gly Gly Arg Val Gln Cys Met Glu Ser Leu Ala Ala Thr 
    50                  55                  60                  


Ser Val Phe Ala Pro Ser Arg Val Ala Val Pro Ala Ala Arg Ala Leu 
65                  70                  75                  80  


Val Arg Ala Gly Thr Val Val Pro Thr Arg Arg Thr Ser Ser Thr Ser 
                85                  90                  95      


Gly Thr Ser Gly Val Lys Cys Ser Ala Ala Val Thr Pro Gln Ala Ser 
            100                 105                 110         


Pro Val Ile Ser Arg Ser Ala Ala Ala Ala 
        115                 120         


<210>  40799
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chloroplant transit peptide

<400>  40799

Met Gly Ala Ala Ala Thr Ser Met Gln Ser Leu Lys Phe Ser Asn Arg 
1               5                   10                  15      


Leu Val Pro Pro Ser Arg Arg Leu Ser Pro Val Pro Asn Asn Val Thr 
            20                  25                  30          


Cys Asn Asn Leu Pro Lys Ser Ala Ala Pro Val Arg Thr Val Lys Cys 
        35                  40                  45              


Cys Ala Ser Ser Trp Asn Ser Thr Ile Asn Gly Ala Ala Ala Thr Thr 
    50                  55                  60                  


Asn Gly Ala Ser Ala Ala Ser Ser 
65                  70          


<210>  40800
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  tdTomato target sequence

<400>  40800
ctgcattcta gttgtggttt                                                   20


<210>  40801
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV primer

<400>  40801
catctacgta ttagtcatcg ctattacca                                         29


<210>  40802
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV primer

<400>  40802
gaaatccccg tgagtcaaac c                                                 21


<210>  40803
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV probe

<400>  40803
tcaatgggcg tggatag                                                      17


<210>  40804
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2 ITR primer

<400>  40804
ggaaccccta gtgatggagt t                                                 21


<210>  40805
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2 ITR primer

<400>  40805
cggcctcagt gagcga                                                       16


<210>  40806
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2 ITR probe

<400>  40806
cactccctct ctgcgcgctc g                                                 21


<210>  40807
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  40807
tatagcatac attatacgaa                                                   20


<210>  40808
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  40808

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40809
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  40809

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40810
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  40810

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40811
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  40811

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Asn Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40812
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  40812

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Tyr Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40813
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  40813

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Trp Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40814
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  40814

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40815
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  40815

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40816
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  40816

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40817
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  40817

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


His Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40818
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  40818

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn His Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40819
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  40819

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Ala 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40820
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  40820

Arg Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Ala Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala 
225                 230                 235                 240 


Ser Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val 
                245                 250                 255     


Val Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly 
            260                 265                 270         


Lys Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His 
        275                 280                 285             


Thr Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg 
    290                 295                 300                 


Met Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp 
305                 310                 315                 320 


Asp Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu 
                325                 330                 335     


Val Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn 
            340                 345                 350         


Val Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp 
        355                 360                 365             


Gln Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu 
    370                 375                 380                 


Ser Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln 
385                 390                 395                 400 


Leu Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp 
                405                 410                 415     


Gly Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu 
            420                 425                 430         


Gly Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp 
        435                 440                 445             


Ala Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser 
    450                 455                 460                 


Phe Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg 
465                 470                 475                 480 


Cys Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro 
                485                 490                 495     


Phe Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser 
            500                 505                 510         


Lys Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys 
        515                 520                 525             


Leu Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg 
    530                 535                 540                 


Phe Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr 
545                 550                 555                 560 


Val Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe 
                565                 570                 575     


Asn Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys 
            580                 585                 590         


Arg Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr 
        595                 600                 605             


Gly Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr 
    610                 615                 620                 


Asn Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr 
625                 630                 635                 640 


Phe Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn 
                645                 650                 655     


Leu Ile Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu 
            660                 665                 670         


Thr Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly 
        675                 680                 685             


Asn Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln 
    690                 695                 700                 


Arg Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly 
705                 710                 715                 720 


Tyr Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met 
                725                 730                 735     


Val Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp 
            740                 745                 750         


Ala Met Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly 
        755                 760                 765             


Lys Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp 
    770                 775                 780                 


Leu Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40821
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  40821

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Gln Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40822
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  40822

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Thr Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40823
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  40823

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Arg Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40824
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  40824

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Tyr Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40825
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  40825

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


His Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40826
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  40826

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Ala Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40827
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  40827

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40828
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40828

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Ala 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40829
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40829

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Val Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40830
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40830

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Gly Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40831
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40831

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu His Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40832
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40832

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Cys Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40833
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40833

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Val Cys Asn Val Lys Lys Leu 
            340                 345                 350         


Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala 
        355                 360                 365             


Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu 
    370                 375                 380                 


Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu 
385                 390                 395                 400 


Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr 
                405                 410                 415     


Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys 
            420                 425                 430         


His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys 
        435                 440                 445             


Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu 
    450                 455                 460                 


Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys 
465                 470                 475                 480 


Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu 
                485                 490                 495     


Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn 
            500                 505                 510         


Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr 
        515                 520                 525             


Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile 
    530                 535                 540                 


Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys 
545                 550                 555                 560 


Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp 
                565                 570                 575     


Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg 
            580                 585                 590         


Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys 
        595                 600                 605             


Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr 
    610                 615                 620                 


Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg 
625                 630                 635                 640 


Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val 
                645                 650                 655     


Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu 
            660                 665                 670         


Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His 
        675                 680                 685             


Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln 
    690                 695                 700                 


Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys 
705                 710                 715                 720 


Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr 
                725                 730                 735     


Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile 
            740                 745                 750         


Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe 
        755                 760                 765             


Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys 
    770                 775                 780                 


Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  40834
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40834

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Gly Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40835
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40835

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Leu Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40836
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40836

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Gln Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40837
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40837

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Ser Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40838
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40838

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Glu Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40839
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40839

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Thr Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40840
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40840

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Asn Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40841
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40841

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Leu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40842
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40842

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Arg Cys Glu Leu Lys 
465                 470                 475                 480 


Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu 
                485                 490                 495     


Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn 
            500                 505                 510         


Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr 
        515                 520                 525             


Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile 
    530                 535                 540                 


Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys 
545                 550                 555                 560 


Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp 
                565                 570                 575     


Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg 
            580                 585                 590         


Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys 
        595                 600                 605             


Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr 
    610                 615                 620                 


Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg 
625                 630                 635                 640 


Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val 
                645                 650                 655     


Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu 
            660                 665                 670         


Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His 
        675                 680                 685             


Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln 
    690                 695                 700                 


Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys 
705                 710                 715                 720 


Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr 
                725                 730                 735     


Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile 
            740                 745                 750         


Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe 
        755                 760                 765             


Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys 
    770                 775                 780                 


Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  40843
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40843

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu 
    370                 375                 380                 


Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu 
385                 390                 395                 400 


Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr 
                405                 410                 415     


Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys 
            420                 425                 430         


His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys 
        435                 440                 445             


Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu 
    450                 455                 460                 


Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys 
465                 470                 475                 480 


Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu 
                485                 490                 495     


Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn 
            500                 505                 510         


Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr 
        515                 520                 525             


Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile 
    530                 535                 540                 


Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys 
545                 550                 555                 560 


Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp 
                565                 570                 575     


Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg 
            580                 585                 590         


Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys 
        595                 600                 605             


Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr 
    610                 615                 620                 


Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg 
625                 630                 635                 640 


Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val 
                645                 650                 655     


Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu 
            660                 665                 670         


Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His 
        675                 680                 685             


Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln 
    690                 695                 700                 


Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys 
705                 710                 715                 720 


Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr 
                725                 730                 735     


Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile 
            740                 745                 750         


Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe 
        755                 760                 765             


Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys 
    770                 775                 780                 


Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  40844
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40844

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Gln Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40845
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40845

Gln Glu Ile Lys Arg Leu Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40846
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40846

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Asp Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40847
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40847

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn 
            500                 505                 510         


Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr 
        515                 520                 525             


Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile 
    530                 535                 540                 


Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys 
545                 550                 555                 560 


Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp 
                565                 570                 575     


Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg 
            580                 585                 590         


Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys 
        595                 600                 605             


Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr 
    610                 615                 620                 


Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg 
625                 630                 635                 640 


Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val 
                645                 650                 655     


Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu 
            660                 665                 670         


Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His 
        675                 680                 685             


Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln 
    690                 695                 700                 


Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys 
705                 710                 715                 720 


Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr 
                725                 730                 735     


Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile 
            740                 745                 750         


Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe 
        755                 760                 765             


Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys 
    770                 775                 780                 


Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  40848
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40848

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Val Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40849
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40849

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Gly Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40850
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40850

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Phe Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40851
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40851

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Tyr Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40852
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40852

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Pro Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40853
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40853

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Thr Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40854
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40854

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Cys Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40855
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40855

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Pro 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40856
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40856

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Gly Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40857
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40857

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40858
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40858

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ile Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40859
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40859

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Lys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40860
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40860

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Gln Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40861
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40861

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Tyr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40862
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40862

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Lys Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40863
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40863

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ala Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40864
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40864

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40865
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40865

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40866
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40866

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Trp Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40867
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40867

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


His Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40868
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40868

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Pro Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40869
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40869

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40870
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40870

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40871
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40871

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Phe Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40872
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40872

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Asn Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40873
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40873

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Pro Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40874
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40874

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Trp Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40875
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40875

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Met Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40876
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40876

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40877
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40877

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Val Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40878
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40878

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Pro Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40879
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40879

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Pro Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40880
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40880

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Met Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40881
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40881

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Arg Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40882
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40882

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Phe Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40883
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40883

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40884
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40884

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Gln Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40885
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40885

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Asn Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40886
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40886

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu His Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40887
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40887

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Val Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40888
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40888

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Gln Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40889
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40889

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Pro Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40890
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40890

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Arg Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40891
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40891

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Trp Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40892
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40892

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Asn Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40893
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40893

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Ser Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40894
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40894

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ser Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40895
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40895

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Arg Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40896
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40896

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Arg Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40897
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40897

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Asp Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40898
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40898

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Gln Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40899
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40899

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Met Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40900
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40900

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Ile Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40901
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40901

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Val Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40902
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40902

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Glu Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40903
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40903

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Met Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40904
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40904

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Gln Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40905
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40905

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Ile Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40906
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40906

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Asn Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40907
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40907

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Gly Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40908
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40908

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Met Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40909
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40909

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Gln Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40910
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40910

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Glu Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40911
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40911

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Ser Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40912
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40912

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Lys Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40913
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40913
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag caccugagga ucacccaggu gcugacggua caggccaccu      120

gaggaucacc caggugguau agugcagcau caaag                                 155


<210>  40914
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40914
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgcaugagga ucacccaugc gcugacggua caggccgcau      120

gaggaucacc caugcgguau agugcagcau caaag                                 155


<210>  40915
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40915
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgccugagga ucacccaggc gcugacggua caggccgccu      120

gaggaucacc caggcgguau agugcagcau caaag                                 155


<210>  40916
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40916
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgccugagca ucagccaggc gcugacggua caggccgccu      120

gagcaucagc caggcgguau agugcagcau caaag                                 155


<210>  40917
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40917
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagca ucagccaugu gcugacggua caggccacau      120

gagcaucagc caugugguau agugcagcau caaag                                 155


<210>  40918
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40918
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagua ucaaccaugu gcugacggua caggccacau      120

gaguaucaac caugugguau agugcagcau caaag                                 155


<210>  40919
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40919
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagaa ucagccaugu gcugacggua caggccacau      120

gagaaucagc caugugguau agugcagcau caaag                                 155


<210>  40920
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40920
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cccuugagga ucacccaugu gcugacggua caggccccuu      120

gaggaucacc caugugguau agugcagcau caaag                                 155


<210>  40921
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40921
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacuugagga ucacccaugu gcugacggua caggccacuu      120

gaggaucacc caugugguau agugcagcau caaag                                 155


<210>  40922
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40922
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag caccugagga ucacccaugu gcugacggua caggccaccu      120

gaggaucacc caugugguau agugcagcau caaag                                 155


<210>  40923
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40923
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagga ucaccuaugu gcugacggua caggccacau      120

gaggaucacc uaugugguau agugcagcau caaag                                 155


<210>  40924
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40924
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacauuagga ucaccaaugu gcugacggua caggccacau      120

uaggaucacc aaugugguau agugcagcau caaag                                 155


<210>  40925
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40925
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacauuagga ucaccgaugu gcugacggua caggccacau      120

uaggaucacc gaugugguau agugcagcau caaag                                 155


<210>  40926
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40926
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacauuagga ucaccuaugu gcugacggua caggccacau      120

uaggaucacc uaugugguau agugcagcau caaag                                 155


<210>  40927
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40927
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagga uuacccaugu gcugacggua caggccacau      120

gaggauuacc caugugguau agugcagcau caaag                                 155


<210>  40928
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40928
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagga uaacccaugu gcugacggua caggccacau      120

gaggauaacc caugugguau agugcagcau caaag                                 155


<210>  40929
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40929
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagga ugacccaugu gcugacggua caggccacau      120

gaggaugacc caugugguau agugcagcau caaag                                 155


<210>  40930
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40930
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagga ccacccaugu gcugacggua caggccacau      120

gaggaccacc caugugguau agugcagcau caaag                                 155


<210>  40931
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40931
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cagaugagga ucacccaugg gcugacggua caggccagau      120

gaggaucacc caugggguau agugcagcau caaag                                 155


<210>  40932
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40932
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugggga ucacccaugu gcugacggua caggccacau      120

ggggaucacc caugugguau agugcagcau caaag                                 155


<210>  40933
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40933
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cacaugagga ucacccaugu gcugacggua caggccacau      120

gaggaucacc caugugguau agugcagcau caaag                                 155


<210>  40934
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40934
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucaccu gaggaucacc caggugagca ucaaag                                 96


<210>  40935
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40935
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucgcau gaggaucacc caugcgagca ucaaag                                 96


<210>  40936
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40936
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucgccu gaggaucacc caggcgagca ucaaag                                 96


<210>  40937
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40937
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucgccu gagcaucagc caggcgagca ucaaag                                 96


<210>  40938
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40938
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gagcaucagc caugugagca ucaaag                                 96


<210>  40939
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40939
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaguaucaac caugugagca ucaaag                                 96


<210>  40940
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40940
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gagaaucagc caugugagca ucaaag                                 96


<210>  40941
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40941
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuu gaggaucacc caugugagca ucaaag                                 96


<210>  40942
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40942
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacuu gaggaucacc caugugagca ucaaag                                 96


<210>  40943
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40943
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucaccu gaggaucacc caugugagca ucaaag                                 96


<210>  40944
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40944
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaucacc uaugugagca ucaaag                                 96


<210>  40945
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40945
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau uaggaucacc aaugugagca ucaaag                                 96


<210>  40946
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40946
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau uaggaucacc gaugugagca ucaaag                                 96


<210>  40947
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40947
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau uaggaucacc uaugugagca ucaaag                                 96


<210>  40948
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40948
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggauuacc caugugagca ucaaag                                 96


<210>  40949
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40949
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggauaacc caugugagca ucaaag                                 96


<210>  40950
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40950
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaugacc caugugagca ucaaag                                 96


<210>  40951
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40951
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaccacc caugugagca ucaaag                                 96


<210>  40952
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40952
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucagau gaggaucacc caugggagca ucaaag                                 96


<210>  40953
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40953
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau ggggaucacc caugugagca ucaaag                                 96


<210>  40954
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40954
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaucacc caugugagca ucagag                                 96


<210>  40955
<211>  145
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40955
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgucaaugac gcugacggua caggccacau gaggaucacc      120

caugugguau agugcagcau cagag                                            145


<210>  40956
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40956
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cucaugagga ucacccauga gcugacggua caggccacau      120

gaggaucacc caugugguau agugcagcau cagag                                 155


<210>  40957
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40957
acuggcgcuu cuaucugauu acucugagcg ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag acauggcagu cguaacgacg cgggucugac gguacaggcc      120

acaugaggau cacccaugug guauagugca gcaucagag                             159


<210>  40958
<211>  145
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  40958
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu auggggccac augaggauca cccauguggu guacagcgca gcgucaauga      120

cgcugacgau agugcagcau caaag                                            145


<210>  40959
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40959

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40960
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40960

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40961
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40961

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  40962
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40962

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  40963
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40963

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  40964
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40964

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  40965
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40965

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40966
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40966

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40967
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40967

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40968
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40968

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40969
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40969

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu 
                325                 330                 335     


Arg Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys 
            340                 345                 350         


Lys Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly 
        355                 360                 365             


Val Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu 
    370                 375                 380                 


Pro Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro 
385                 390                 395                 400 


Lys Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu 
                405                 410                 415     


Lys Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu 
            420                 425                 430         


Arg Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu 
        435                 440                 445             


Glu Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp 
    450                 455                 460                 


Trp Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met 
465                 470                 475                 480 


Asp Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr 
                485                 490                 495     


Gly Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Ser Ile 
            500                 505                 510         


Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile Trp 
        515                 520                 525             


Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn Tyr 
    530                 535                 540                 


Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala Phe 
545                 550                 555                 560 


Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu Ile 
                565                 570                 575     


Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile Ile 
            580                 585                 590         


Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp Asn 
        595                 600                 605             


Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly Arg 
    610                 615                 620                 


Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu Pro 
625                 630                 635                 640 


Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp Ser 
                645                 650                 655     


Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn 
            660                 665                 670         


Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser 
        675                 680                 685             


Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly 
    690                 695                 700                 


Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val 
705                 710                 715                 720 


Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala 
                725                 730                 735     


Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu 
            740                 745                 750         


Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser 
        755                 760                 765             


Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln 
    770                 775                 780                 


Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly 
785                 790                 795                 800 


Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys 
                805                 810                 815     


Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg 
            820                 825                 830         


Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile 
        835                 840                 845             


Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg 
    850                 855                 860                 


Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg 
865                 870                 875                 880 


Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly 
                885                 890                 895     


Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg 
            900                 905                 910         


Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His 
        915                 920                 925             


Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu 
    930                 935                 940                 


Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn 
945                 950                 955                 960 


Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys 
                965                 970                 975     


Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
            980                 985     


<210>  40970
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40970

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Val Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro 
        675                 680                 685             


Thr Asp Ile Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Phe Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Ser Ala Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val 
            740                 745                 750         


Leu Val Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40971
<211>  972
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40971

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser 
    930                 935                 940                 


Tyr Lys Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr 
945                 950                 955                 960 


Lys Arg Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
                965                 970         


<210>  40972
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40972

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40973
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40973

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40974
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40974

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40975
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40975

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  40976
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  40976

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  40977
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX 387 construct

<400>  40977

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu 
    210                 215                 220                 


Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg 
            260                 265                 270         


Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro 
        275                 280                 285             


Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala 
    290                 295                 300                 


Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  40978
<211>  1005
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX 395 construct

<400>  40978

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala Gln 
    210                 215                 220                 


Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg Leu 
            260                 265                 270         


Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro Ser 
        275                 280                 285             


Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala Tyr 
    290                 295                 300                 


Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val Thr Ser Pro Lys  Lys Lys Arg Lys Val  
        995                 1000                 1005 


<210>  40979
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX 485 construct

<400>  40979

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala Gln 
    210                 215                 220                 


Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg Leu 
            260                 265                 270         


Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro Ser 
        275                 280                 285             


Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala Tyr 
    290                 295                 300                 


Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val 
        995     


<210>  40980
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX 486 construct

<400>  40980

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala Gln 
    210                 215                 220                 


Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg Leu 
            260                 265                 270         


Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro Ser 
        275                 280                 285             


Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala Tyr 
    290                 295                 300                 


Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Lys His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val 
        995     


<210>  40981
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX 487 construct

<400>  40981

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala Gln 
    210                 215                 220                 


Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg Leu 
            260                 265                 270         


Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro Ser 
        275                 280                 285             


Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala Tyr 
    290                 295                 300                 


Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val 
        995     


<210>  40982
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX 488 construct

<400>  40982

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala 
    210                 215                 220                 


Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro 
        275                 280                 285             


Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala 
    290                 295                 300                 


Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  40983
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX 489 construct

<400>  40983

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala 
    210                 215                 220                 


Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro 
        275                 280                 285             


Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala 
    290                 295                 300                 


Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  40984
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX 490 construct

<400>  40984

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala 
    210                 215                 220                 


Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro 
        275                 280                 285             


Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala 
    290                 295                 300                 


Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Lys His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  40985
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX 491 construct

<400>  40985

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala 
    210                 215                 220                 


Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro 
        275                 280                 285             


Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala 
    290                 295                 300                 


Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  40986
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX domain sequence

<400>  40986

Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn Ala 
1               5                   10                  15      


Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val Arg 
            20                  25                  30          


Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys Lys 
        35                  40                  45              


Pro Glu Val Met Pro Gln 
    50                  


<210>  40987
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX domain sequence

<400>  40987

Val Ile Ser Asn Asn Ala Ala Asn Asn Leu Arg Met Leu Leu Asp Asp 
1               5                   10                  15      


Tyr Thr Lys Met Lys Glu Ala Ile Leu Gln Val Tyr Trp Gln Glu Phe 
            20                  25                  30          


Lys Asp Asp His Val Gly Leu Met Cys Lys Phe Ala 
        35                  40                  


<210>  40988
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX domain sequence

<400>  40988

Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met 
1               5                   10                  15      


Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys 
            20                  25                  30          


Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly 
        35                  40                  45              


Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu 
    50                  55                  60                  


Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu 
65                  70                  75                  80  


Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
                85                  90      


<210>  40989
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX domain sequence

<400>  40989

Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
1               5                   10                  15      


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
            20                  25                  30          


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
        35                  40                  45              


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
    50                  55                  60                  


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
65                  70                  75                  80  


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
                85                  90                  95      


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
            100                 105                 110         


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
        115                 120                 125             


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe 
    130                 135                 140     


<210>  40990
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX domain sequence

<400>  40990

Pro Val Val Glu Arg Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile 
1               5                   10                  15      


Asn Glu Val Lys Lys Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val 
            20                  25                  30          


Phe Trp Ser Gly Val Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Pro Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser 
    50                  55                  60                  


Leu Glu Asn Pro Lys Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu 
65                  70                  75                  80  


Leu Tyr Leu Glu Lys Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp 
                85                  90                  95      


Glu Ala Trp Glu Arg Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His 
            100                 105                 110         


Ile Glu Arg Glu Glu Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala 
        115                 120                 125             


Val Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg 
    130                 135                 140                 


Leu Lys Glu Met Asp Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu 
145                 150                 155                 160 


Gln Lys Trp Tyr Gly Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala 
                165                 170                 175     


Glu 
    


<210>  40991
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX domain sequence

<400>  40991

Asn Arg Val Val Asp Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His 
1               5                   10                  15      


Ser Ile Gln Tyr Arg Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly 
            20                  25                  30          


Lys Arg Glu Phe Tyr Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile 
        35                  40                  45              


Arg Phe Thr Asp Gly Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly 
    50                  55                  60                  


Leu Leu Tyr Gly Gly Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp 
65                  70                  75                  80  


Pro Asp Asp Glu Gln Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg 
                85                  90                  95      


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
            100                 105                 110         


Leu Ile Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn 
        115                 120                 125             


Lys Lys Ile Gly Arg Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
    130                 135                 140                 


Glu Arg Arg Glu Val Val Asp 
145                 150     


<210>  40992
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX domain sequence

<400>  40992

Pro Ser Asn Ile Lys Pro Val Asn Leu Ile Gly Val Asp Arg Gly Glu 
1               5                   10                  15      


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
            20                  25                  30          


Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro Thr Asp Ile Leu Arg Ile 
        35                  40                  45              


Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala Ile Gln Ala Ala Lys Glu 
    50                  55                  60                  


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Phe Ala Ser Lys 
65                  70                  75                  80  


Ser Arg Asn Leu Ala Asp Asp Met Val Arg Asn Ser Ala Arg Asp Leu 
                85                  90                  95      


Phe Tyr His Ala Val Thr His Asp Ala Val Leu Val Phe Glu Asn Leu 
            100                 105                 110         


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Thr Glu Arg 
        115                 120                 125             


Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
    130                 135                 140                 


Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
145                 150                 155                 160 


Ser Lys Thr Cys 
                


<210>  40993
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX domain sequence

<400>  40993

Ser Asn Cys Gly Phe Thr Ile Thr Thr Ala Asp Tyr Asp Gly Met Leu 
1               5                   10                  15      


Val Arg Leu Lys Lys Thr Ser Asp Gly Trp Ala Thr Thr Leu Asn Asn 
            20                  25                  30          


Lys Glu Leu Lys Ala Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys 
        35                  40                  45              


Arg Gln Thr Val Glu Lys Glu Leu Ser Ala Glu Leu Asp Arg Leu Ser 
    50                  55                  60                  


Glu Glu Ser Gly Asn Asn Asp Ile Ser Lys Trp Thr Lys Gly Arg Arg 
65                  70                  75                  80  


Asp Glu Ala Leu Phe Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val 
                85                  90                  95      


Gln Glu Gln Phe Val Cys Leu Asp Cys Gly His Glu Val His 
            100                 105                 110 


<210>  40994
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX domain sequence

<400>  40994

Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu 
1               5                   10                  15      


Asn Ser Asn Ser Thr Glu Phe Lys Ser Tyr Lys Ser Gly Lys Gln Pro 
            20                  25                  30          


Phe Val Gly Ala Trp Gln Ala Phe Tyr Lys Arg Arg Leu Lys Glu Val 
        35                  40                  45              


Trp Lys Pro Asn Ala 
    50              


<210>  40995
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX domain sequence

<400>  40995

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln 
    50                  55      


<210>  40996
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX domain sequence

<400>  40996

Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu Leu Thr Asp 
1               5                   10                  15      


Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp Glu Glu Phe 
            20                  25                  30          


Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala 
        35                  40                  


<210>  40997
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX domain sequence

<400>  40997

Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys 
1               5                   10                  15      


Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys 
            20                  25                  30          


Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly 
        35                  40                  45              


Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu 
    50                  55                  60                  


Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu 
65                  70                  75                  80  


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
                85                  90  


<210>  40998
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX domain sequence

<400>  40998

Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
1               5                   10                  15      


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
            20                  25                  30          


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
        35                  40                  45              


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
    50                  55                  60                  


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
65                  70                  75                  80  


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
                85                  90                  95      


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
            100                 105                 110         


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
        115                 120                 125             


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe 
    130                 135                 140     


<210>  40999
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX domain sequence

<400>  40999

Pro Leu Val Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val 
1               5                   10                  15      


Cys Asn Val Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val 
            20                  25                  30          


Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro 
        35                  40                  45              


Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg 
    50                  55                  60                  


Tyr Gln Phe Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu 
65                  70                  75                  80  


Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys 
                85                  90                  95      


Val Glu Gly Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser 
            100                 105                 110         


Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys 
        115                 120                 125             


Ala Ser Phe Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe 
    130                 135                 140                 


Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly 
145                 150                 155                 160 


Lys Pro Phe Ala Ile Glu Ala Glu 
                165             


<210>  41000
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX domain sequence

<400>  41000

Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala 
1               5                   10                  15      


Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile 
            20                  25                  30          


Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro 
        35                  40                  45              


Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser 
    50                  55                  60                  


Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn 
65                  70                  75                  80  


Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe 
                85                  90                  95      


Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala 
            100                 105                 110         


Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln 
        115                 120                 125             


Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val 
    130                 135                 140                 


Leu Asp 
145     


<210>  41001
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX domain sequence

<400>  41001

Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu 
1               5                   10                  15      


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
            20                  25                  30          


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
        35                  40                  45              


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Ala Lys Glu 
    50                  55                  60                  


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
65                  70                  75                  80  


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
                85                  90                  95      


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
            100                 105                 110         


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
        115                 120                 125             


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
    130                 135                 140                 


Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
145                 150                 155                 160 


Ser Lys Thr Cys 
                


<210>  41002
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX domain sequence

<400>  41002

Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu 
1               5                   10                  15      


Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly 
            20                  25                  30          


Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys 
        35                  40                  45              


Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser 
    50                  55                  60                  


Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser 
65                  70                  75                  80  


Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val 
                85                  90                  95      


Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His 
            100                 105                 110 


<210>  41003
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX domain sequence

<400>  41003

Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu 
1               5                   10                  15      


Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn 
            20                  25                  30          


Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys 
        35                  40                  45              


Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
    50                  55              


<210>  41004
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX domain sequence

<400>  41004

Pro Leu Val Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val 
1               5                   10                  15      


Cys Asn Val Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val 
            20                  25                  30          


Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro 
        35                  40                  45              


Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg 
    50                  55                  60                  


Tyr Gln Leu Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu 
65                  70                  75                  80  


Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys 
                85                  90                  95      


Val Glu Gly Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser 
            100                 105                 110         


Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys 
        115                 120                 125             


Ala Ser Phe Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe 
    130                 135                 140                 


Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly 
145                 150                 155                 160 


Lys Pro Phe Ala Ile Glu Ala Glu 
                165             


<210>  41005
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX domain sequence

<400>  41005

Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly Glu 
1               5                   10                  15      


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
            20                  25                  30          


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
        35                  40                  45              


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
    50                  55                  60                  


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
65                  70                  75                  80  


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
                85                  90                  95      


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
            100                 105                 110         


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
        115                 120                 125             


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
    130                 135                 140                 


Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
145                 150                 155                 160 


Ser Lys Thr Cys 
                


<210>  41006
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  41006

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  41007
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  41007

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  41008
<211>  972
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  41008

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu 
                965                 970         


<210>  41009
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCasX variant

<400>  41009

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Lys Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Ser 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Ala Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Ala Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Ala Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  41010
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41010
atatttgcat gtcgctatgt gttctgggaa atcaccataa acgtgaaatg tctttggatt       60

tgggaatctt ataagttctg tatgagacca c                                      91


<210>  41011
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41011
atatttagca tgtcgctatg tgttctggga aatcaccata aacgtgaaat gtctttggat       60

ttgggaatct tataagttct gtatgagacc ac                                     92


<210>  41012
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41012
atatttgcat gtctgcaagg cattctggat agtcaccata aacgtgaaat gtctttggat       60

ttgggaatct tataagttct gtatgagacc ac                                     92


<210>  41013
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41013
atatttgcat gtcgctatgt gttctgggaa attgacctaa gtgtaaagtg tctttggatt       60

tgggaatctt ataagttctg tatgagacca c                                      91


<210>  41014
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41014
atatttagca ttctgcaagg cattctggat agtgacctaa gtgtaaagtg tctttggatt       60

tgggaatctt atatattctg tatgagacca c                                      91


<210>  41015
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41015
atatttagca ttctgcaagg cattctggat agtcaccata aacgtgaaat gtctttggat       60

ttgggaatct tataagttct gtatgagacc ac                                     92


<210>  41016
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41016
atatttgcat gtcgctatgt gttctgggaa acttgaccta agtgtaaagt tgagatttcc       60

ttcaggtttt ataagttctg tatgagacca c                                      91


<210>  41017
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41017
atatttgcat gtcgctatgt gttctgggaa atcaccataa acgtgaaatt tgagatttcc       60

ttcaggtttt ataagttctg tatgagacca c                                      91


<210>  41018
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41018
atatttgcat gtcgctatgt gttctgggaa acttgaccta agtgtaaagt tgagatttcc       60

ttcaggttta tatagttctg tatgagacca c                                      91


<210>  41019
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41019
atatttagca tgtcgctatg tgttctggga aacttgacct aagtgtaaag ttgagatttc       60

cttcaggttt atatagttct gtatgagacc ac                                     92


<210>  41020
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41020
atatttgcat gatttcccat gattccttca ttcaccataa acgtgaaatg tctttggatt       60

tgggaatctt ataagttctg tatgagacca c                                      91


<210>  41021
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41021
atatttgcat gtcgctatgt gttctgggaa atcttaccgt aacttgaaag tagtctttgg       60

atttgggaat cttataagtt ctgtatgaga ccac                                   94


<210>  41022
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41022
atatttgcat atttcccatg attccttcat cttaccgtaa cttgaaagta gtctttggat       60

ttgggaatct tatatattct gtatgagacc ac                                     92


<210>  41023
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41023
atatttgcat atttcccatg attccttcat tcaccataaa cgtgaaatgt ctttggattt       60

gggaatctta taagttctgt atgagaccac                                        90


<210>  41024
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41024
atatttgcat gtcgctatgt gttctgggaa actcttaccg taacttgaaa gtatgagatt       60

tccttcaggt tttataagtt ctgtatgaga ccac                                   94


<210>  41025
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41025
atatttgcat gtcgctatgt gttctgggaa actcttaccg taacttgaaa gtatgagatt       60

tccttcaggt ttatatagtt ctgtatgaga ccac                                   94


<210>  41026
<211>  249
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41026
gccacctctt ttgcatattg gcacccacaa tccaccgcgg ctatgaggcc agtataaggc       60

ggtaaaatta cgataagata tgggatttta cgtgatcgaa gacatcaaag taagcgtaag      120

cacgaaagtt gttctgcaac ataccactgt aggaaattat gctaaatatg aaaccgacca      180

taagttatcc taaccaaaag atgatttgat tgaagggctt aaaataggtg tgacagtaac      240

ccttgagtc                                                              249


<210>  41027
<211>  249
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41027
tcccttaccc agggtgcccc gggcgctcat ttgcatgtcc cacccaacag gtaaacctga       60

cagatcggtc gcggccaggt acggcctggc ggtcagagca ccaaacttac gagccttgtg      120

atgagttccg ttacatgaaa ttctcctaaa ggctccaaga tggacaggaa agcgctcgat      180

tcggttaccg taaggaaaac aaatgagaaa ctcccgtgcc ttataagacc tggggacgga      240

cttatttgc                                                              249


<210>  41028
<211>  249
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41028
cccttaccca gggtgccccg ggcgctcatt tgcatgtccc acccaacagg taaacctgac       60

aggtcatcgc ggccaggtac gacctggcgg tcagagcacc aaacatacga gccttgtgat      120

gagttccgtt gcatgaaatt ctcccaaagg ctccaagatg gacaggaaag ggcgcggttc      180

ggtcaccgta agtagaatag gtgaaagact cccgtgcctt ataaggcctg tgggtgactt      240

cttctcaac                                                              249


<210>  41029
<211>  249
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41029
caggctctgc cccgcctccg gggctatttg catacgacca tttccagtaa ttcccagcag       60

ccaccgtagc tatatttggt agaacaacga gcactttctc aactccagtc aataactacg      120

ttagttgcat tacacattgg gctaatataa atagaggtta aatctctagg tcatttaaga      180

gaagtcggcc tatgtgtaca gacatttgtt ccaggggctt taaatagctg gtggtggaac      240

tcaatattc                                                              249


<210>  41030
<211>  400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UbC protein promoter variant

<400>  41030
ggcctccgcg ccgggttttg gcgcctcccg cgggcgcccc cctcctcacg gcgagcgctg       60

ccacgtcaga cgaagggcgc agcgagcgtc ctgatccttc cgcccggacg ctcaggacag      120

cggcccgctg ctcataagac tcggccttag aaccccagta tcagcagaag gacattttag      180

gacgggactt gggtgactct agggcactgg ttttctttcc agagagcgga acaggcgagg      240

aaaagtagtc ccttctcggc gattctgcgg agggatctcc gtggggcggt gaacgccgat      300

gattatataa ggacgcgccg ggtgtggcac agctagttcc gtcgcagccg ggatttgggt      360

cgcggttctt gtttgtggat cgctgtgatc gtcacttggt                            400


<210>  41031
<211>  164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Jet protein promoter variant

<400>  41031
gggcggagtt agggcggagc caatcagcgt gcgccgttcc gaaagttgcc ttttatggct       60

gggcggagaa tgggcggtga acgccgatga ttatataagg acgcgccggg tgtggcacag      120

ctagttccgt cgcagccggg atttgggtcg cggttcttgt ttgt                       164


<210>  41032
<211>  252
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U1a protein promoter variant

<400>  41032
aatggaggcg gtactatgta gatgagaatt caggagcaaa ctgggaaaag caactgcttc       60

caaatatttg tgatttttac agtgtagttt tggaaaaact cttagcctac caattcttct      120

aagtgtttta aaatgtggga gccagtacac atgaagttat agagtgtttt aatgaggctt      180

aaatatttac cgtaactatg aaatgctacg catatcatgc tgttcaggct ccgtggccac      240

gcaactcata ct                                                          252


<210>  41033
<211>  229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MeP426 protein promoter variant

<400>  41033
agctgaatgg ggtccgcctc ttttccctgc ctaaacagac aggaactcct gccaattgag       60

ggcgtcaccg ctaaggctcc gccccagcct gggctccaca accaatgaag ggtaatctcg      120

acaaagagca aggggtgggg cgcgggcgcg caggtgcagc agcacacagg ctggtcggga      180

gggcggggcg cgacgtctgc cgtgcggggt cccggcatcg gttgcgcgc                  229


<210>  41034
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MiniCMV protein promoter variant

<400>  41034
gtaggcgtgt acggtgggag gtctatataa gcagagct                               38


<210>  41035
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SFCp protein promoter variant

<400>  41035
ggatcctact gacgaggggc ttgtccaaac aagcccgggc atgcctaaac atgccctgat       60

gcaatcctga cgtcgtgaag caatgattat gcaatttgag catgtccaga ctagccctga      120

cggatgacgc ttgacgcaat tcctgaggca agtctgagct tgttcaaact tgtcttgaag      180

aaattatgac ggactgacgt atggtgcaat attggggcaa tgcttgacgt tcgcggtagg      240

cgtgtacggt gggaggtcta tataagcaga gctcgtttag tgaaccgtca gatcgcctgg      300

agacgccatc cacgctgttt tgacctccat agaagtcacc gggaccgatc cagc            354


<210>  41036
<211>  197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miniSV40 protein promoter variant

<400>  41036
tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc ccgcccctaa       60

ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt atttatgcag      120

aggccgaggc cgcctcggcc tctgagctat tccagaagta gtgaggaggc ttttttggag      180

gcctaggctt ttgcaaa                                                     197


<210>  41037
<211>  178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pJB42CAT5 protein promoter variant

<400>  41037
ctgacaaatt cagtataaaa gcttggggct ggggccgagc actggggact ttgagggtgg       60

ccaggccagc gtaggaggcc agcgtaggat cctgctggga gcggggaact gagggaagcg      120

acgccgagaa agcaggcgta ccacggaggg agagaaaagc tccggaagcc cagcagcg        178


<210>  41038
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MLP protein promoter variant

<400>  41038
ggggggctat aaaagggggt gggggcgttc gtcctcactc t                           41


<210>  41039
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV core protein promoter variant

<400>  41039
gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      180

tgggaggtct atataagcag agct                                             204


<210>  41040
<211>  234
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EFS protein promoter variant

<400>  41040
tggctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg agaagttggg       60

gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa actgggaaag      120

tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt atataagtgc      180

agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac aggt            234


<210>  41041
<211>  212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miniEF1alpha protein promoter variant

<400>  41041
gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgat       60

ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc      120

gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc      180

tttttcgcaa cgggtttgcc gccagaacac ag                                    212


<210>  41042
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hRPL30 protein promoter variant

<400>  41042
ccccgcagcc attctagcta gcggtaccaa tagcaaccgg cagctgccct ccgcttttgc       60

tccgcccctt ctgcttgcga tctgtttccg cttccggtcc cgcagttccg gctctgccgt      120

gaagagcttt gcattgtggg aagtctttcc tttctcgttc cccggccatc ttagcggctg      180

ctgttggtga gtgggctcct accgaccgag gtttaggcag cgcggggagc tttgcgggtt      240

gccatttgta actccggatc ctaaaattcc tgtcctgttc tctgtctctt ctaggttggg      300

ggccgtcccg ctcctaaggc aggaa                                            325


<210>  41043
<211>  243
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hRPS18 protein promoter variant

<400>  41043
agccccggaa ccttcgctgt tctcttacct atgaacctta cgaactgtaa agaaaggcgc       60

accggaagtt gtggtaccca agccatactc tcataaatcc agccaggtcg cgctgaaaca      120

gtttccggaa gcacttctcc tagatcgcac cgcctcttcc tcctggaagc tatataatga      180

tatcgcgtca cttccgctct ctcttccaca ggaggcctac acgccgccgc ttgtgctgca      240

gcc                                                                    243


<210>  41044
<211>  223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hRPL13a protein promoter variant

<400>  41044
acagcgctga ccgcggaggt ccaaccggaa gaatgtccgg attggacatt cggaagaggg       60

cccgccttcc ctggggaatc tctgcgcacg cgcagaacgc ttcgaccaat gaaaacacag      120

gaagccgtcc gcgcaaccgc gttgcgtcac ttctgccgcc cctgtttcaa gggataagaa      180

accctgcgac aaaacctcct ccttttccaa gcggctgccg aag                        223


<210>  41045
<211>  400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG-depleted UbC promoter

<400>  41045
accaagtgac gatcacagct atccacaaac aagaactgcg acccaaatcc cggctgcgac       60

ggaactagct gtgccacacc cggcgcgtcc ttatataatc atcggcgttc accgccccaa      120

ggagatccct ccgcagaatc gccgagaagg gactactttt cctcgcctgt tccgctctct      180

ggaaagaaaa ccagtgccct agagtcaccc aagtcccgtc ctaaaatgtc cttctgctga      240

tactggggtt ctaaggctga gtcttatgag cagcgggctg ctgtcctgag cgtccaggcg      300

gaaggatcag gaggctcgct gcgcccttcg tctgacgtgg cagcgctcgc cgtgaggagg      360

ggggcgcccg cgggaggcgc caaaacccgg tgcggaggcc                            400


<210>  41046
<211>  400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Strongly CpG-depleted UbC promoter

<400>  41046
accaagtgat gatcacagct atccacaaac aagaactgag acccaaatcc cagctgccac       60

ggaactagct gtgccacacc cggtgtctcc ttatataatc ataggaattc accgccccaa      120

ggagatccct ccgcagaatt gccgagaagg gactactttt cctagcctgt tccactctct      180

ggaaagaaaa ccagtgccct agagtcaccc aagtcccttc ctaaaatgtc cttctgctga      240

tactggggtt ctaaggctga gtcttatgag cagagggctg ctgtcctgag ggtccaggcg      300

gaaggatcag gaggctcact gagcccttcg tctgacgtgg cagatctggc cgtgaggagg      360

ggggaacccg cgggaggcac caaaacccgg tggggaggcc                            400


<210>  41047
<211>  400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG-free UbC promoter

<400>  41047
accaagtgat gatcacagct atccacaaac aagaactgag acccaaatcc cagctgccat       60

ggaactagct gtgccacacc tggtgtctcc ttatataatc ataggaattc actgccccaa      120

ggagatccct ctgcagaatt gctgagaagg gactactttt cctagcctgt tccactctct      180

ggaaagaaaa ccagtgccct agagtcaccc aagtcccttc ctaaaatgtc cttctgctga      240

tactggggtt ctaaggctga gtcttatgag cagagggctg ctgtcctgag ggtccaggtg      300

gaaggatcag gaggctcact gagccctttg tctgatgtgg cagatctggc tgtgaggagg      360

ggggaacctg tgggaggcac caaaacctgg tggggaggcc                            400


<210>  41048
<211>  252
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG-depleted U1a promoter

<400>  41048
aatggaggcg gtactatgta gatgagaatt caggagcaaa ctgggaaaag caactgcttc       60

caaatatttg tgatttttac agtgtagttt tggaaaaact cttagcctac caattcttct      120

aagtgtttta aaatgtggga gccagtacac atgaagttat agagtgtttt aatgaggctt      180

aaatatttac cgtaactatg aaatgctaca catatcatgc tgttcaggct ctgtggccat      240

gcaactcata ct                                                          252


<210>  41049
<211>  252
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG-free U1a promoter

<400>  41049
aatggaggtg gtactatgta gatgagaatt caggagcaaa ctgggaaaag caactgcttc       60

caaatatttg tgatttttac agtgtagttt tggaaaaact cttagcctac caattcttct      120

aagtgtttta aaatgtggga gccagtacac atgaagttat agagtgtttt aatgaggctt      180

aaatatttac tgtaactatg aaatgctaca catatcatgc tgttcaggct ctgtggccat      240

gcaactcata ct                                                          252


<210>  41050
<211>  241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG-depleted U6 promoter

<400>  41050
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatat ttgatgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttctat ttcttggctt tatatatctt gtggaaagga      240

c                                                                      241


<210>  41051
<211>  241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG-free U6 promoter

<400>  41051
gagggcctat ttcccatgat tccttcatat ttgcatatac aatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatat ttgatgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttacca taacttgaaa gtatttctat ttcttggctt tatatatctt gtggaaagga      240

c                                                                      241


<210>  41052
<211>  3006
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG-free cMycNLS-Stx491-cMycNLS

<400>  41052
atggctccag ctgccaagag agtgaagctg gactctagac aagagatcaa gaggatcaac       60

aagattagaa gaaggctggt caaggacagc aacaccaaga aggcaggcaa gacaggcccc      120

atgaagaccc tgcttgtcag agtgatgacc cctgacctga gagagagact ggaaaacctg      180

agaaagaagc ctgagaacat ccctcagcct atctccaaca ccagcagagc caacctgaac      240

aagctgctga cagactacac agagatgaag aaagccatcc tgcatgtgta ctgggaagag      300

ttccagaaag accctgtggg cctgatgagc agagtggccc agcctgccag caagaagatt      360

gaccagaaca aactgaagcc agagatggat gagaagggca acctgaccac agctggcttt      420

gcctgctctc agtgtggcca gcctctgttt gtgtacaagc tggaacaagt gtctgagaaa      480

ggcaaggcct acaccaacta ctttggcaga tgcaatgtgg ctgagcatga gaagctgatc      540

ctgctggccc agctgaagcc tgaaaaggac tctgatgagg ctgtgaccta cagcctgggc      600

aagtttggac agagagccct ggacttctac agcatccatg tgaccaaaga aagcacacac      660

cctgtgaagc ccctggctca gattgctggc aacagatatg cctctggacc tgtgggcaaa      720

gccctgtctg atgcctgcat gggaaccatt gccagctttc tgagcaagta ccaggacatc      780

atcattgagc accagaaagt ggtcaagggg aaccagaaga ggctggaatc tctgagagag      840

ctggctggca aagagaacct ggaatacccc tctgtgaccc tgcctcctca gcctcacacc      900

aaagagggtg ttgatgccta caatgaagtg attgccagag tcaggatgtg ggtcaacctg      960

aatctgtggc agaagctgaa gctgagcagg gatgatgcca agcctctgct gagactgaag     1020

ggcttcccta gcttcccact ggtggaaagg caggctaatg aagtggattg gtgggacatg     1080

gtctgcaatg tgaagaaact gatcaatgag aagaaagagg atggcaaggt tttctggcag     1140

aacctggctg gctacaagag gcaagaagcc ctgaggcctt acctgtcctc tgaggaagat     1200

aggaagaagg ggaagaagtt tgccagatac cagctgggag atctgctgct gcacctggaa     1260

aagaaacatg gggaagattg gggcaaagtg tatgatgagg cctgggagag aattgacaag     1320

aaggtggaag gcctgagcaa gcacattaag ctggaagagg aaagaagatc tgaggatgcc     1380

cagagcaagg ctgccctgac tgattggctg agagccaagg ccagctttgt gattgagggc     1440

ctgaaagagg ctgacaagga tgagttctgt agatgtgaac tgaagctgca aaagtggtat     1500

ggggacctga ggggcaagcc ctttgccatt gaggcagaga acagcatcct ggacatcagt     1560

ggcttcagca agcagtacaa ctgtgccttc atttggcaga aggatggggt taagaagctc     1620

aacctgtacc tgatcatcaa ctacttcaaa ggtggcaagc tgaggttcaa gaagatcaag     1680

ccagaggcct ttgaggccaa caggttctac acagtgatca acaaaaagtc tggggagatt     1740

gtgcccatgg aagtgaactt caactttgat gatcccaacc tcatcatcct gccactggcc     1800

tttggcaaga gacagggcag agaattcatc tggaatgacc tgctgagcct ggaaacaggc     1860

agcctgaaac tggccaatgg cagagtgatt gagaaaaccc tgtacaacag aaggaccaga     1920

caggatgagc ctgcactgtt tgtggccctg acctttgaga gaagggaagt gctggatagc     1980

agcaacatca agcccatgaa cctgattgga gtggacagag gggagaatat ccctgctgtc     2040

attgccctga cagaccctga gggctgtccc ctgagcagat tcaaggactc cctgggcaac     2100

cccacacaca ttctgagaat tggggagagc tacaaagaga agcagagaac catccaggcc     2160

aagaaagaag tggaacagag gagagctgga ggctactcta ggaagtatgc cagcaaagcc     2220

aagaatctgg ctgatgacat ggtcagaaac acagccaggg acctgctgta ctatgctgtg     2280

acccaggatg ccatgctgat ctttgagaat ctgagcagag gatttgggag acaaggcaag     2340

aggaccttca tggctgaaag acagtacacc aggatggaag attggctgac tgccaaactg     2400

gcctatgagg gactgagcaa gacctacctg tccaagacac tggcccagta tacctccaag     2460

acctgcagca attgtggctt caccatcacc tctgcagact atgacagagt gctggaaaag     2520

ctcaagaaaa cagccacagg ctggatgacc accatcaatg ggaaagagct gaaggttgag     2580

ggccagatca cctactacaa cagatacaaa aggcagaatg tggttaagga cctgtctgtg     2640

gaactggaca gactgtctga ggaatctgtg aacaatgaca tcagcagctg gaccaagggc     2700

agatctgggg aagctctgag cctgctgaag aagagattca gccacagacc tgtgcaagag     2760

aagtttgtgt gtctgaactg tggctttgag acacatgctg atgaacaggc tgctctgaac     2820

attgccagaa gctggctgtt cctgagaagc caagagtaca agaagtacca gaccaacaag     2880

accacaggca acactgacaa gagggccttt gtggaaacct ggcagagctt ctacagaaag     2940

aaactcaaag aagtctggaa gcctgctgtg ggcagccctg cagctaaaag ggtcaagctg     3000

gactga                                                                3006


<210>  41053
<211>  208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG-free bGH-polyA sequence

<400>  41053
ctgtgccttc tagttgccag ccatctgttg tttgcccctc cccagtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcacattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagagaa tagcaggcat gctgggga                                         208


<210>  41054
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG-free 5' ITR

<400>  41054
tgctcactca ctcactcact gaggcctgca gagcaaagct ctgcagtctg gggacctttg       60

gtccccaggc ctcagtgagt gagtgagtga gcagagaggg agtggccaac tccatcacta      120

ggggttcct                                                              129


<210>  41055
<211>  131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG-free 3' ITR

<400>  41055
tctgctcact cactcactca ctgaggcctg cagagcaaag ctctgcagtc tggggacctt       60

tggtccccag gcctcagtga gtgagtgagt gagcagagag ggagtggcca actccatcac      120

taggggttcc t                                                           131


<210>  41056
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41056
agtccctcaa gtccttccag                                                   20


<210>  41057
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41057
agcagcagca gcagcagcag                                                   20


<210>  41058
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41058
tcagccgccg ccgcaggcac                                                   20


<210>  41059
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41059
agggtcgcca tggcggtctc                                                   20


<210>  41060
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41060
tcagcttttc cagggtcgcc                                                   20


<210>  41061
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41061
ctatgaaggc ctttaacaaa                                                   20


<210>  41062
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41062
gccgcagccg cccccgccgc                                                   20


<210>  41063
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41063
gccacagccg ggccgggtgg                                                   20


<210>  41064
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41064
tcagccacag ccgggccggg                                                   20


<210>  41065
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41065
cggtcggtgc agcggctcct                                                   20


<210>  41066
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41066
tgccgggcgg gagaccgcca                                                   20


<210>  41067
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41067
gaccctggaa aagctgatga                                                   20


<210>  41068
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41068
gctgctgctg gaaggacttg                                                   20


<210>  41069
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41069
ggcggcggcg gcggcggcgg                                                   20


<210>  41070
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41070
ggcggcggct gaggaagctg                                                   20


<210>  41071
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41071
tgtgcctgcg gcggcggctg                                                   20


<210>  41072
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41072
ggcggcggcg ggggcggctg                                                   20


<210>  41073
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41073
ccgccgcccc cgccgccacc                                                   20


<210>  41074
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41074
tcgaaggcct tcatcagctt ttc                                               23


<210>  41075
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41075
cctggaaaag ctgatgaagg cct                                               23


<210>  41076
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41076
gcggctcctc agccacagcc ggg                                               23


<210>  41077
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41077
gctgaggagc cgctgcaccg acc                                               23


<210>  41078
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41078
tctactgtgt gcacttcatc                                                   20


<210>  41079
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41079
tccactgtgt gcacttcatc                                                   20


<210>  41080
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41080
ctcatctact gtgtgcactt                                                   20


<210>  41081
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41081
ctcatccact gtgtgcactt                                                   20


<210>  41082
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41082
agcacataga ggacgccgtg                                                   20


<210>  41083
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41083
agcacataga ggatgccgtg                                                   20


<210>  41084
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41084
gtgcccttgt gccctgcctc                                                   20


<210>  41085
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41085
gcgcccttgt gccctgcctc                                                   20


<210>  41086
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41086
gcaggtggtg accttgtgga                                                   20


<210>  41087
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41087
taaacaagtc agcagccggt                                                   20


<210>  41088
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41088
ttgaaaagaa aaccttaccg                                                   20


<210>  41089
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41089
ttgaaaagaa aaccttaccg                                                   20


<210>  41090
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41090
tttcaacgaa aagcagcccc                                                   20


<210>  41091
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41091
tttcaatgaa aagcagcccc                                                   20


<210>  41092
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41092
acgaaaagca gcccccaagc                                                   20


<210>  41093
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41093
atgaaaagca gcccccaagc                                                   20


<210>  41094
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41094
tagcttgaac ttccccttta                                                   20


<210>  41095
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41095
tagcttgaat ttccccttta                                                   20


<210>  41096
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41096
aatacaatgt ccagcacaca                                                   20


<210>  41097
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41097
aatacaatgt ccagtacaca                                                   20


<210>  41098
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41098
tggtaatttg tgtttgtgtg                                                   20


<210>  41099
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41099
tggtaatttg tgtttgtgta                                                   20


<210>  41100
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41100
tcccagtgag aaagatcaag                                                   20


<210>  41101
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41101
ccccagtgag aaagatcaag                                                   20


<210>  41102
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41102
cactgggatg aactagcagc                                                   20


<210>  41103
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41103
cactggggtg aactagcagc                                                   20


<210>  41104
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41104
agctagtaac gatgctaacg                                                   20


<210>  41105
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41105
agcgagtaac gatgctaacg                                                   20


<210>  41106
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41106
cgcagctagg ctaaagagtc                                                   20


<210>  41107
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41107
cgcagctagg ttaaagagtc                                                   20


<210>  41108
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41108
ttgattgtgt ttcttatttg                                                   20


<210>  41109
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41109
ttgattgtat ttcttatttg                                                   20


<210>  41110
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41110
catcaaataa gaaacacaat                                                   20


<210>  41111
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41111
catcaaataa gaaatacaat                                                   20


<210>  41112
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41112
aaaatacagt atacctcctc                                                   20


<210>  41113
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41113
aaaatacagt atgcctcctc                                                   20


<210>  41114
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41114
aacacagagg aggtatactg                                                   20


<210>  41115
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41115
aacacagagg aggcatactg                                                   20


<210>  41116
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41116
gattgttaat cataaagtct                                                   20


<210>  41117
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41117
gattgttaat cataaagtcc                                                   20


<210>  41118
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41118
agactttatg attaacaatc                                                   20


<210>  41119
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41119
ggactttatg attaacaatc                                                   20


<210>  41120
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41120
tcattgcact tccatgttgg                                                   20


<210>  41121
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41121
tcgttgcact tccatgttgg                                                   20


<210>  41122
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41122
tttgggatat ttgacctgcg                                                   20


<210>  41123
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41123
tttgggatat ttgacctgca                                                   20


<210>  41124
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41124
gaagagctac aacgcaggtc                                                   20


<210>  41125
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41125
gaagagctac aatgcaggtc                                                   20


<210>  41126
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41126
tgttctctct ttttctttgg                                                   20


<210>  41127
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41127
cgttctctct ttttctttgg                                                   20


<210>  41128
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41128
aatggagaat acgggtaaca                                                   20


<210>  41129
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41129
aatggagaat acaggtaaca                                                   20


<210>  41130
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41130
aagtagtagt tagtaatcaa                                                   20


<210>  41131
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41131
aagtagtagt tagtaaccaa                                                   20


<210>  41132
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41132
cagcaaataa ttttggaaag                                                   20


<210>  41133
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41133
caacaaataa ttttggaaag                                                   20


<210>  41134
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41134
aaaattattt gctgtgaatt                                                   20


<210>  41135
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41135
aaaattattt gttgtgaatt                                                   20


<210>  41136
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41136
aattcacagc aaataatttt                                                   20


<210>  41137
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41137
aattcacaac aaataatttt                                                   20


<210>  41138
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41138
taaacttcta attcacagca                                                   20


<210>  41139
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41139
taaacttcta attcacaaca                                                   20


<210>  41140
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41140
ttctcaagtt agttttagat                                                   20


<210>  41141
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41141
ttctcaagtt ggttttagat                                                   20


<210>  41142
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41142
caagttagtt ttagattaga                                                   20


<210>  41143
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41143
caagttggtt ttagattaga                                                   20


<210>  41144
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41144
gtcctttctg cccaccagca                                                   20


<210>  41145
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41145
gtccttcctg cccaccagca                                                   20


<210>  41146
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41146
tgcccaccag cacatgcttt                                                   20


<210>  41147
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41147
tgcccaccag cacatgcttt                                                   20


<210>  41148
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41148
gcccaccagc acatgctttc                                                   20


<210>  41149
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41149
gcccaccagc acatgctttc                                                   20


<210>  41150
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41150
acttgtagat tgatttaggg                                                   20


<210>  41151
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41151
acttgtagat taatttaggg                                                   20


<210>  41152
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41152
ccctaaatca atctacaagt                                                   20


<210>  41153
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41153
ccctaaatta atctacaagt                                                   20


<210>  41154
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41154
tagtcagtct cgccttacct                                                   20


<210>  41155
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41155
tagtcagtct tgccttacct                                                   20


<210>  41156
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41156
cctgctccgc ctgcaccatg                                                   20


<210>  41157
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41157
cctgctccgc ctgcaccatg                                                   20


<210>  41158
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41158
ctaaaaacaa aaacatccat                                                   20


<210>  41159
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41159
ctagaaacaa aaacatccat                                                   20


<210>  41160
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41160
agggaatcag aggcaatcat                                                   20


<210>  41161
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41161
agggaatcag aggcaatcat                                                   20


<210>  41162
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41162
attgtctgtc cccttacccg                                                   20


<210>  41163
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41163
gttgtctgtc cccttacccg                                                   20


<210>  41164
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41164
ctcacttgct tttctattgt                                                   20


<210>  41165
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41165
ctcacttgct tttctgttgt                                                   20


<210>  41166
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41166
tgctgccaag ggatgctgac                                                   20


<210>  41167
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41167
tgctgccaag ggatgccgac                                                   20


<210>  41168
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41168
agcgttgaag tactgtcccc                                                   20


<210>  41169
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41169
agcgttgaat tactgtcccc                                                   20


<210>  41170
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41170
tctagcgttg aagtactgtc                                                   20


<210>  41171
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41171
tctagcgttg aattactgtc                                                   20


<210>  41172
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41172
tcactgagga tgaaatggca                                                   20


<210>  41173
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41173
tcgctgagga tgaaatggca                                                   20


<210>  41174
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41174
tcctcagtga ggaaggtgat                                                   20


<210>  41175
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41175
tcctcagcga ggaaggtgat                                                   20


<210>  41176
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41176
tcccacagtg gtttgcctat                                                   20


<210>  41177
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41177
tcccaaagtg gtttgcctat                                                   20


<210>  41178
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41178
attgctccca gcattataat                                                   20


<210>  41179
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41179
attgctccca gcattataac                                                   20


<210>  41180
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41180
cttcccccga gtccctttgg                                                   20


<210>  41181
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41181
cttcccctga gtccctttgg                                                   20


<210>  41182
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41182
cccgagtccc tttggctccc                                                   20


<210>  41183
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41183
cctgagtccc tttggctccc                                                   20


<210>  41184
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41184
atcctgtccc caagttcatc                                                   20


<210>  41185
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41185
atcctatccc caagttcatc                                                   20


<210>  41186
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41186
ggtgatgaca atttattaat                                                   20


<210>  41187
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41187
ggtgatggca atttattaat                                                   20


<210>  41188
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41188
cagctatctt ctcatcaata                                                   20


<210>  41189
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41189
cagctaactt ctcatcaata                                                   20


<210>  41190
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41190
tcacagctat cttctcatca                                                   20


<210>  41191
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41191
tcacagctaa cttctcatca                                                   20


<210>  41192
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41192
tctctttgtt ctgttgtaat                                                   20


<210>  41193
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41193
tctgtttgtt ctgttgtaat                                                   20


<210>  41194
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41194
ctttgttctg ttgtaatttt                                                   20


<210>  41195
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41195
gtttgttctg ttgtaatttt                                                   20


<210>  41196
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41196
tatccgccta taccatacaa                                                   20


<210>  41197
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41197
tatccgccta tgccatacaa                                                   20


<210>  41198
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41198
accttcatat ccgcctatac                                                   20


<210>  41199
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41199
accttcatat ccgcctatgc                                                   20


<210>  41200
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41200
tgagcaatgg cgtgagaaac                                                   20


<210>  41201
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41201
ttagcaatgg cgtgagaaac                                                   20


<210>  41202
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41202
cacgccattg ctcaggaaca                                                   20


<210>  41203
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41203
cacgccattg ctaaggaaca                                                   20


<210>  41204
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41204
tctaccgcat caacacacta                                                   20


<210>  41205
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41205
tctaccgcat caatacacta                                                   20


<210>  41206
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41206
agaagcctga taaaatctct                                                   20


<210>  41207
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41207
agaagcctaa taaaatctct                                                   20


<210>  41208
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41208
gtcagcgtca catacatcag                                                   20


<210>  41209
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41209
gtcagcgtca catacattag                                                   20


<210>  41210
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41210
agtcccaaat ctgggtgcta                                                   20


<210>  41211
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41211
agtcccaaat ctgggtgtta                                                   20


<210>  41212
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41212
gtacacacgt gtccttgaca                                                   20


<210>  41213
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41213
atacacacgt gtccttgaca                                                   20


<210>  41214
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41214
gaatgcctca tctggtcaaa                                                   20


<210>  41215
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41215
gaacgcctca tctggtcaaa                                                   20


<210>  41216
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41216
cgctgcgccg tttctgcata                                                   20


<210>  41217
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41217
cgctgtgccg tttctgcata                                                   20


<210>  41218
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41218
accccggcct cggaaacctt                                                   20


<210>  41219
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41219
accccggcct cggaaacctt                                                   20


<210>  41220
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41220
gccagcgcat gtgtcctttc                                                   20


<210>  41221
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41221
gccagcacat gtgtcctttc                                                   20


<210>  41222
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41222
ccttgaaagg acacatgcgc                                                   20


<210>  41223
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41223
ccttgaaagg acacatgtgc                                                   20


<210>  41224
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41224
tcatcggaga gcacaccctg                                                   20


<210>  41225
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41225
tcatcggaga gcacaacctg                                                   20


<210>  41226
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41226
gttgcgttga tttgattttt                                                   20


<210>  41227
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41227
gttgcattga tttgattttt                                                   20


<210>  41228
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41228
gaggttcggt ggacacaggc                                                   20


<210>  41229
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41229
gaggctcggt ggacacaggc                                                   20


<210>  41230
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41230
gtggacacag gcagctgccc                                                   20


<210>  41231
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41231
gtggacacag gcagctgccc                                                   20


<210>  41232
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41232
gggtgctgga gatatcatgg                                                   20


<210>  41233
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41233
gggtgctgga gatgtcatgg                                                   20


<210>  41234
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41234
accaattttc tatttttgga                                                   20


<210>  41235
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41235
atcaattttc tatttttgga                                                   20


<210>  41236
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41236
acctctgaaa ccccgaaatt                                                   20


<210>  41237
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41237
acctctgaaa ccccaaaatt                                                   20


<210>  41238
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41238
caaatttcgg ggtttcagag                                                   20


<210>  41239
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41239
caaattttgg ggtttcagag                                                   20


<210>  41240
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41240
ctatgaaggc ctttaacaaa                                                   20


<210>  41241
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41241
ctgtgaaggc ctttaacaaa                                                   20


<210>  41242
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41242
ggttcgctat gaaggccttt                                                   20


<210>  41243
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41243
ggttcgctgt gaaggccttt                                                   20


<210>  41244
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41244
tagcgaacct gaagtcaagc                                                   20


<210>  41245
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41245
cagcgaacct gaagtcaagc                                                   20


<210>  41246
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41246
ccctgttagc aaaaacgaag                                                   20


<210>  41247
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41247
ctctgttagc aaaaacgaag                                                   20


<210>  41248
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41248
tttttgctaa cagggggaaa                                                   20


<210>  41249
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41249
tttttgctaa cagagggaaa                                                   20


<210>  41250
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41250
cattggatct ctcagcccat                                                   20


<210>  41251
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41251
cattgaatct ctcagcccat                                                   20


<210>  41252
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41252
ggccaaaatc aaagcatctt                                                   20


<210>  41253
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41253
ggccaacatc aaagcatctt                                                   20


<210>  41254
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41254
ctaacaaacc ccccttctct                                                   20


<210>  41255
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41255
ctagcaaacc ccccttctct                                                   20


<210>  41256
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41256
gtgctgttct gaagatccag                                                   20


<210>  41257
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41257
atgctgttct gaagatccag                                                   20


<210>  41258
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41258
gaacagcacg gaaaagtttg                                                   20


<210>  41259
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41259
gaacagcatg gaaaagtttg                                                   20


<210>  41260
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41260
ccgctcagcc ttggatgttc                                                   20


<210>  41261
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41261
tcgctcagcc ttggatgttc                                                   20


<210>  41262
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41262
ctcagccttg gatgttcttt                                                   20


<210>  41263
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41263
ctcagccttg gatgttcttt                                                   20


<210>  41264
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41264
tgcatcagct ttatttgttc                                                   20


<210>  41265
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41265
tgcatcagct ttatttattc                                                   20


<210>  41266
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41266
ggccattttg agggttctga                                                   20


<210>  41267
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41267
ggccattttg aaggttctga                                                   20


<210>  41268
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41268
aaatggccag aattcccgat                                                   20


<210>  41269
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41269
aaatggccag aattcccgat                                                   20


<210>  41270
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41270
actcttatct tgaaaccaat                                                   20


<210>  41271
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41271
actcttatct taaaaccaat                                                   20


<210>  41272
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41272
agataagagt tgaaataatt                                                   20


<210>  41273
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41273
agataagagt tgaaataatt                                                   20


<210>  41274
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41274
tctgtggcag aggggatggc                                                   20


<210>  41275
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41275
tctgtggcag aggggatggc                                                   20


<210>  41276
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41276
gtggcagagg ggatggctgc                                                   20


<210>  41277
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41277
gtggcagagg ggatggctgc                                                   20


<210>  41278
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41278
ctcgtggtga caggtcacag                                                   20


<210>  41279
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41279
cttgtggtga caggtcacag                                                   20


<210>  41280
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41280
cagtttttgc ttgagttgta                                                   20


<210>  41281
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41281
cagtttttgc ttgagttgta                                                   20


<210>  41282
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41282
gaccctaatc ctgcagcccc                                                   20


<210>  41283
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41283
gaccctaatc ctgcaacccc                                                   20


<210>  41284
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41284
catgaagcaa agcaagcctc                                                   20


<210>  41285
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41285
cacgaagcaa agcaagcctc                                                   20


<210>  41286
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41286
tgagaaccta gaccttgctg                                                   20


<210>  41287
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41287
tgagaaccta gaccttgctg                                                   20


<210>  41288
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41288
tggttttgac atggacgcga                                                   20


<210>  41289
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HTT spacer

<400>  41289
tggttttgac atggacacga                                                   20


<210>  41290
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41290
gaggaggacg gcctggccga                                                   20


<210>  41291
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41291
accgctgcgc caaggtgcgg                                                   20


<210>  41292
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41292
atggccttct tcctggcttc                                                   20


<210>  41293
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41293
gccaggccgt cctcctcgga                                                   20


<210>  41294
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41294
gtgctcgggt gcttcggcca                                                   20


<210>  41295
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41295
gcaccaccac gtaggtgcca                                                   20


<210>  41296
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41296
tcctggcttc ctggtgaaga                                                   20


<210>  41297
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41297
tggcttcctg gtgaagatga                                                   20


<210>  41298
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41298
ccaggaagcc aggaagaagg                                                   20


<210>  41299
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41299
tccttgcatg gggccaggat                                                   20


<210>  41300
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41300
cctctcccct ggccctcatg                                                   20


<210>  41301
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41301
tcatgggcac cgtcagctcc                                                   20


<210>  41302
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41302
agcagcagca gcagcagcag                                                   20


<210>  41303
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41303
tcccgcgggc gcccgtgcgc                                                   20


<210>  41304
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41304
ggacgaggac ggcgactacg                                                   20


<210>  41305
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41305
ggccgtcctc ctcggaacgc                                                   20


<210>  41306
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41306
cctggccgaa gcacccgagc                                                   20


<210>  41307
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41307
cgcagcggtg gaaggtggct                                                   20


<210>  41308
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41308
tgctgctgct gctgctgctg ctc                                               23


<210>  41309
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41309
ggaaggtggc tgtggttccg tgc                                               23


<210>  41310
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41310
accttccacc gctgcgccaa ggt                                               23


<210>  41311
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41311
ccgctgcgcc aaggtgcggg tgt                                               23


<210>  41312
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41312
cacgtaggtg ccaggcaacc tcc                                               23


<210>  41313
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41313
gcagtgcgct ctgactgcga gag                                               23


<210>  41314
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41314
cctgcaggcc caggctgccc gcc                                               23


<210>  41315
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41315
ggaagaaggc catggaagac atg                                               23


<210>  41316
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41316
ttcttcctgg cttcctggtg aag                                               23


<210>  41317
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41317
caggagctcc agtgacagcc                                                   20


<210>  41318
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41318
agtgacagcc ccatcccagg                                                   20


<210>  41319
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCSK9 spacer

<400>  41319
ctggagctcc tgggaggcct                                                   20


<210>  41320
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41320
ggcctggagg ctatccagcg                                                   20


<210>  41321
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41321
ggtttactca cgtcatccag                                                   20


<210>  41322
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41322
tgaattgcta tgtgtctggg                                                   20


<210>  41323
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41323
ctgctggatg acgtgagtaa                                                   20


<210>  41324
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41324
ggaaatttga ctttccattc                                                   20


<210>  41325
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41325
atgtcggatg gatgaaaccc                                                   20


<210>  41326
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41326
tccatccgac attgaagttg                                                   20


<210>  41327
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41327
atctcttgta ctacactgaa                                                   20


<210>  41328
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41328
gtgtagtaca agagatagaa                                                   20


<210>  41329
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41329
cacggcaggc atactcatct                                                   20


<210>  41330
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41330
tagatcgaga catgtaagca                                                   20


<210>  41331
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41331
aatttacata ctctgcttag                                                   20


<210>  41332
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41332
aagcagagta tgtaaattgg                                                   20


<210>  41333
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41333
tgaagctgac agcattcggg                                                   20


<210>  41334
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41334
ggaatgcccg ccagcgcgac                                                   20


<210>  41335
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41335
ggtttactca cgtcatccag                                                   20


<210>  41336
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41336
ctctccattc ttcagtaagt                                                   20


<210>  41337
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41337
gacttgtctt tcagcaagga                                                   20


<210>  41338
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41338
cccccactga aaaagatgag                                                   20


<210>  41339
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41339
tagatcgaga catgtaagca                                                   20


<210>  41340
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41340
ccactgtctt tttcatagat                                                   20


<210>  41341
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41341
caaggtcaaa aacttacctc                                                   20


<210>  41342
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41342
ttgctaacct ttttcttttc                                                   20


<210>  41343
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41343
tttcttttca ggtttgaaga                                                   20


<210>  41344
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41344
tttcaggttt gaagatgccg                                                   20


<210>  41345
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41345
ggtttgaaga tgccgcattt                                                   20


<210>  41346
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41346
aacctgaaaa gaaaagaaaa                                                   20


<210>  41347
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41347
tccaatccaa atgcggcatc                                                   20


<210>  41348
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41348
tggtcaaata aacaaagctg                                                   20


<210>  41349
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41349
cattttccag attaggaatc                                                   20


<210>  41350
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41350
ggaatgcccg ccagcgcgac                                                   20


<210>  41351
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41351
tgaagctgac agcattcggg                                                   20


<210>  41352
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41352
caaggtcaaa aacttacctc                                                   20


<210>  41353
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41353
tttcttttca ggtttgaaga                                                   20


<210>  41354
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41354
aggcatagtt ttatacctga                                                   20


<210>  41355
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41355
attctctgct ggatgacgtg                                                   20


<210>  41356
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41356
ggccgagatg tctcgctccg                                                   20


<210>  41357
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41357
atgtttgatg tatctgagca                                                   20


<210>  41358
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41358
gatacatcaa acatggagac                                                   20


<210>  41359
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41359
atgatgctgc ttacatgtct                                                   20


<210>  41360
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41360
cgtcatccag cagagaatgg                                                   20


<210>  41361
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41361
gctggatgac gtgagtaaac                                                   20


<210>  41362
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41362
aggccagaaa gagagagtag                                                   20


<210>  41363
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41363
actgtctttt tcatagatcg                                                   20


<210>  41364
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41364
aggtcaaaaa cttacctcca                                                   20


<210>  41365
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41365
atgatgctgc ttacatgtct                                                   20


<210>  41366
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41366
acttatatta aacgcgtgcc                                                   20


<210>  41367
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41367
cggcccgaat gctgtcagct                                                   20


<210>  41368
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41368
agcgtgagtc tctcctaccc                                                   20


<210>  41369
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41369
ttggagtacc tgaggaatat                                                   20


<210>  41370
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41370
agcagagaat ggaaagtcaa                                                   20


<210>  41371
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41371
atccgacatt gaagttgact                                                   20


<210>  41372
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41372
gacattgaag ttgacttact                                                   20


<210>  41373
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41373
cttgtactac actgaattca                                                   20


<210>  41374
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41374
ttttcagtgg gggtgaattc                                                   20


<210>  41375
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41375
tgggctgtga caaagtcaca                                                   20


<210>  41376
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41376
agacatgtaa gcagcatcat                                                   20


<210>  41377
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41377
tcaaacctga aaagaaaaga                                                   20


<210>  41378
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41378
aaatgcggca tcttcaaacc                                                   20


<210>  41379
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41379
aatccaaatg cggcatcttc                                                   20


<210>  41380
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41380
gagcaggttg ctccacaggt                                                   20


<210>  41381
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41381
taaaacttga tgtgttatct                                                   20


<210>  41382
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41382
aacatcaaca tcttggtcag                                                   20


<210>  41383
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41383
cggcccgaat gctgtcagct                                                   20


<210>  41384
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41384
tgattggctg ggcacgcgtt                                                   20


<210>  41385
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41385
cgctccgtgg ccttagctgt                                                   20


<210>  41386
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41386
aataaacaaa gctggccatc                                                   20


<210>  41387
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41387
tataagattc atatttactt                                                   20


<210>  41388
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41388
gggccgagat gtctcgctcc                                                   20


<210>  41389
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41389
aatgtcggat ggatgaaacc                                                   20


<210>  41390
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41390
gctgtgctcg cgctactctc                                                   20


<210>  41391
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41391
ctggcctgga ggctatccag                                                   20


<210>  41392
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41392
ccattctctg ctggatgacg                                                   20


<210>  41393
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41393
ctgaagaatg gagagagaat                                                   20


<210>  41394
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41394
cctccatgat gctgcttaca                                                   20


<210>  41395
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41395
caatttacat actctgctta                                                   20


<210>  41396
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41396
cactcaaagc ttgttaagat                                                   20


<210>  41397
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41397
acaagctttg agtgcaagag                                                   20


<210>  41398
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41398
tcggcccgaa tgctgtcagc ttc                                               23


<210>  41399
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41399
gccacggagc gagacatctc ggc                                               23


<210>  41400
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41400
ggatagcctc caggccagaa aga                                               23


<210>  41401
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41401
ttctggcctg gaggctatcc agc                                               23


<210>  41402
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41402
cgggagggta ggagagactc acg                                               23


<210>  41403
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41403
aacctgaatc tttggagtac ctg                                               23


<210>  41404
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41404
tgacgtgagt aaacctgaat ctt                                               23


<210>  41405
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41405
tctgctggat gacgtgagta aac                                               23


<210>  41406
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41406
aggtttactc acgtcatcca gca                                               23


<210>  41407
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41407
ctttccattc tctgctggat gac                                               23


<210>  41408
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41408
gaaatttgac tttccattct ctg                                               23


<210>  41409
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41409
cagagaatgg aaagtcaaat ttc                                               23


<210>  41410
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41410
aaatttcctg aattgctatg tgt                                               23


<210>  41411
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41411
cagtaagtca acttcaatgt cgg                                               23


<210>  41412
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41412
ccgacattga agttgactta ctg                                               23


<210>  41413
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41413
tcttcagtaa gtcaacttca atg                                               23


<210>  41414
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41414
gttgacttac tgaagaatgg aga                                               23


<210>  41415
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41415
ccagtccttg ctgaaagaca agt                                               23


<210>  41416
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41416
gtctttctat ctcttgtact aca                                               23


<210>  41417
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41417
tgaattcacc cccactgaaa aag                                               23


<210>  41418
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41418
catactcatc tttttcagtg ggg                                               23


<210>  41419
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41419
caggcatact catctttttc agt                                               23


<210>  41420
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41420
tgtcacagcc caagatagtt aag                                               23


<210>  41421
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41421
tttcaggttt gaagatgccg cat                                               23


<210>  41422
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41422
ttcaggtttg aagatgccgc att                                               23


<210>  41423
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41423
ggtttgaaga tgccgcattt gga                                               23


<210>  41424
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41424
tgaagatgcc gcatttggat tgg                                               23


<210>  41425
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41425
taaattttcc cccaaattct aag                                               23


<210>  41426
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41426
ggaaaattta gaaatataat tga                                               23


<210>  41427
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41427
ctaagaggga gcaaaagtat ctg                                               23


<210>  41428
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41428
cttcagatac ttttgctccc tct                                               23


<210>  41429
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41429
ggccgagatg tctcgctccg                                                   20


<210>  41430
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41430
tcaggtactc caaagattca                                                   20


<210>  41431
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41431
gtgggggtga attcagtgta                                                   20


<210>  41432
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41432
tgaagctgac agcattcggg                                                   20


<210>  41433
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41433
ctgctggatg acgtgagtaa                                                   20


<210>  41434
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41434
tttcctgaca tcatgcttgt                                                   20


<210>  41435
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41435
ggccgagatg tctcgctccg                                                   20


<210>  41436
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41436
gtgtagtaca agagatagaa                                                   20


<210>  41437
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41437
ttctatctct tgtactacac                                                   20


<210>  41438
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41438
cgctggatag cctccaggcc                                                   20


<210>  41439
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41439
ggcctggagg ctatccagcg                                                   20


<210>  41440
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41440
cgatattcct caggtactcc                                                   20


<210>  41441
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41441
cccccactga aaaagatgag                                                   20


<210>  41442
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41442
tgggtaggaa cagcagccta                                                   20


<210>  41443
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41443
aggccagaaa gagagagtag                                                   20


<210>  41444
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41444
tctgctgggc ccataacaca                                                   20


<210>  41445
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41445
tagatcgaga catgtaagca                                                   20


<210>  41446
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41446
tgagagatct ggttgttggt                                                   20


<210>  41447
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41447
tgaagctgac agcattcggg                                                   20


<210>  41448
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41448
tctgctgggc ccataacaca                                                   20


<210>  41449
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41449
ttcttttgtt cctgtcttcc                                                   20


<210>  41450
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41450
gtaatcccag cactttgaga                                                   20


<210>  41451
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41451
tagatcgaga catgtaagca                                                   20


<210>  41452
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41452
atctgtaatg gattttaaat                                                   20


<210>  41453
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41453
ttaccaaact tgtctaattt                                                   20


<210>  41454
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41454
tgtcttcctt tctgtgaagg                                                   20


<210>  41455
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41455
ccttcacaga aaggaagaca                                                   20


<210>  41456
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41456
aatgaataag gcaccagagg                                                   20


<210>  41457
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41457
tcccaacttg gcctcccaaa                                                   20


<210>  41458
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41458
gatgcaaaga gctctcttag                                                   20


<210>  41459
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41459
ccatgttggc cagtctggtc                                                   20


<210>  41460
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41460
cctcaaactc tttgctcctc                                                   20


<210>  41461
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41461
ggcctggagg ctatccagcg                                                   20


<210>  41462
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41462
cgttcctcat ctcccacctc                                                   20


<210>  41463
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41463
tgtgtcttta tttctatgat                                                   20


<210>  41464
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41464
gttatgcccg gacggggcca                                                   20


<210>  41465
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41465
caaaaaaaaa aaaaaaaatt                                                   20


<210>  41466
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41466
ttggctcagg gcctgctttt                                                   20


<210>  41467
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41467
cgcgagcaca gctaaggcca                                                   20


<210>  41468
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41468
actcacgctg gatagcctcc                                                   20


<210>  41469
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41469
actctctctt tctggcctgg                                                   20


<210>  41470
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41470
agggtaggag agactcacgc                                                   20


<210>  41471
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41471
ctcaggtact ccaaagattc                                                   20


<210>  41472
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41472
cgtgagtaaa cctgaatctt                                                   20


<210>  41473
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41473
ttcctgaatt gctatgtgtc                                                   20


<210>  41474
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41474
atactcatct ttttcagtgg                                                   20


<210>  41475
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41475
ttaccccact taactatctt                                                   20


<210>  41476
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41476
ggccacggag cgagacatct                                                   20


<210>  41477
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M spacer

<400>  41477
tataagtgga ggcgtcgcgc                                                   20


<210>  41478
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41478
agcagaaggc aagggctggg                                                   20


<210>  41479
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41479
atgttcatga gtttggagat                                                   20


<210>  41480
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41480
tgagtttgga gataatacag                                                   20


<210>  41481
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41481
tcgccataac tcgctaggcc                                                   20


<210>  41482
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41482
gcacgcacac ggccttcgtc                                                   20


<210>  41483
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41483
gctcgaaatt gatgatgccc                                                   20


<210>  41484
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41484
atgtgactgc tgacaaaga                                                    19


<210>  41485
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41485
gaaggccgtg tgcgtgctga                                                   20


<210>  41486
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41486
gcctgcatgg attccatgtt c                                                 21


<210>  41487
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41487
aaccaggacc tcggcgtggc cta                                               23


<210>  41488
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41488
tgagtttgga gataatacag cag                                               23


<210>  41489
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41489
tatccagaaa acacggtggg cca                                               23


<210>  41490
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41490
aaaacacggt gggccaaagg atg                                               23


<210>  41491
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41491
tgatctcact ctcaggagac cat                                               23


<210>  41492
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41492
tgatctcact ctcaggagac cat                                               23


<210>  41493
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41493
agtcgtttgg cttgtggtgt aat                                               23


<210>  41494
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41494
tgttcatgag tttggagata ata                                               23


<210>  41495
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41495
taaaggactg actgaaggcc tgc                                               23


<210>  41496
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41496
ggggacagtg ttatcacaag                                                   20


<210>  41497
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41497
ccacaccttc actggtccat                                                   20


<210>  41498
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41498
taaaggaaag taatggacca                                                   20


<210>  41499
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41499
ctgtgagggg taaaggtaaa                                                   20


<210>  41500
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41500
ggatagagga ttaaagtgag                                                   20


<210>  41501
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41501
tggtgttgca aagacattac                                                   20


<210>  41502
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41502
tgagtttgga gataatacag                                                   20


<210>  41503
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41503
ctggtccatt actttccttt                                                   20


<210>  41504
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41504
aaattccaac tggttaagga                                                   20


<210>  41505
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41505
ccctggccat tgagaatcca                                                   20


<210>  41506
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41506
caggctggag tgcagtggca                                                   20


<210>  41507
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41507
cctgtgcccc tctctttcct                                                   20


<210>  41508
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41508
cctcagcatg gacctctgaa                                                   20


<210>  41509
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41509
cttctcactg tggctgtacc                                                   20


<210>  41510
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41510
ttattaggca tgttggagac                                                   20


<210>  41511
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41511
gtcataacta atgacatttc                                                   20


<210>  41512
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41512
aatattatga ggttcttaaa                                                   20


<210>  41513
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41513
tggcttcaac acattctttt                                                   20


<210>  41514
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41514
ctttcttttt ctttctctct                                                   20


<210>  41515
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41515
taagaatttg gatcataacc                                                   20


<210>  41516
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41516
ttcttttttt aaactcctga                                                   20


<210>  41517
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41517
gaggactgca acggaaaccc                                                   20


<210>  41518
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41518
ttattaggca tgttggagac                                                   20


<210>  41519
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41519
tatggtatac tacttgtaaa                                                   20


<210>  41520
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41520
tcccagagca ttagtgtgta                                                   20


<210>  41521
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41521
tgacatttcc tgtattagtt                                                   20


<210>  41522
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41522
aggccataaa tacttggata                                                   20


<210>  41523
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41523
atagacacat cggccacacc                                                   20


<210>  41524
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41524
accttccctg agcagcttgc                                                   20


<210>  41525
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41525
tccagaactg aaagctagct                                                   20


<210>  41526
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41526
ttattaggca tgttggagac                                                   20


<210>  41527
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41527
ccacaccttc actggtccat                                                   20


<210>  41528
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41528
taaaggaaag taatggacca                                                   20


<210>  41529
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41529
ctggtccatt actttccttt                                                   20


<210>  41530
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41530
atagacacat cggccacacc                                                   20


<210>  41531
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41531
ggatagagga ttaaagtgag                                                   20


<210>  41532
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41532
gaggactgca acggaaaccc                                                   20


<210>  41533
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41533
caggagacca ttgcatcatt                                                   20


<210>  41534
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41534
tcttcttata aataggctgt                                                   20


<210>  41535
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41535
tatggtatac tacttgtaaa                                                   20


<210>  41536
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41536
tgacatttcc tgtattagtt                                                   20


<210>  41537
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41537
ttaataggtc tccagatttt                                                   20


<210>  41538
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41538
tcctttggcc caccgtgttt                                                   20


<210>  41539
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41539
tgagtttgga gataatacag                                                   20


<210>  41540
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41540
taaaaggata tgcataaaac                                                   20


<210>  41541
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41541
gggataagca acaccttggt                                                   20


<210>  41542
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41542
gttcccttct cactgtggct                                                   20


<210>  41543
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41543
tgcaaaacac caagtagaca                                                   20


<210>  41544
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41544
tgattaaata acataaaaag                                                   20


<210>  41545
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41545
tctctcctag cctctggaac                                                   20


<210>  41546
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41546
cttttcttaa aggaaagtaa                                                   20


<210>  41547
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41547
atgcttcccc acaccttcac                                                   20


<210>  41548
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41548
ggattccatg ttcatgagtt                                                   20


<210>  41549
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41549
gagtttggag ataatacagc                                                   20


<210>  41550
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41550
tatctccaaa ctcatgaaca                                                   20


<210>  41551
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41551
catgaacatg gaatccatgc                                                   20


<210>  41552
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41552
tttttcatta ttaggcatgt                                                   20


<210>  41553
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41553
tattaggcat gttggagact                                                   20


<210>  41554
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41554
tcaggagacc attgcatcat                                                   20


<210>  41555
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41555
gtgtgcggcc aatgatgcaa                                                   20


<210>  41556
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41556
tattatctcc aaactcatga aca                                               23


<210>  41557
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41557
ggccaatgat gcaatggtct cct                                               23


<210>  41558
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41558
atggtctcct gagagtgaga tca                                               23


<210>  41559
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41559
gcacgcacac ggccttcgtc                                                   20


<210>  41560
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41560
gcacgcacac gaccttcgtc                                                   20


<210>  41561
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41561
agaaaacacg gtgggccaaa                                                   20


<210>  41562
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41562
tttggcccac cgtgttttct                                                   20


<210>  41563
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41563
tcaatagaca catcggccac                                                   20


<210>  41564
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41564
ttggccgcac actggtggta                                                   20


<210>  41565
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41565
caattacacc acaagccaaa                                                   20


<210>  41566
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41566
cacaccttca ctggtccatt                                                   20


<210>  41567
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41567
tgcaggcctt cagtcagtcc                                                   20


<210>  41568
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41568
cactttaatc ctctatccag                                                   20


<210>  41569
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41569
gagagtgaga tcacagaatc                                                   20


<210>  41570
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41570
tgaaaaagca gatgacttgg                                                   20


<210>  41571
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 spacer

<400>  41571
atagacacat cggccacacg                                                   20


<210>  41572
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41572
aagtggctgc gtaccacacc                                                   20


<210>  41573
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41573
gacgggtgtg gtacgcagcc act                                               23


<210>  41574
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41574
gacgggtgtg gtacgcagcc cct                                               23


<210>  41575
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41575
tctacgtgcc cttctccaat gcg                                               23


<210>  41576
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41576
ccatggctca gccaggtagt act                                               23


<210>  41577
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41577
agtactgtgg gtactcgaag                                                   20


<210>  41578
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41578
cttctccaat gcgacgggtg                                                   20


<210>  41579
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41579
gctcagccag gtagtactgt                                                   20


<210>  41580
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41580
gtgcccttct ccaatgcgac                                                   20


<210>  41581
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41581
cgtgcccttc tccaatgcga                                                   20


<210>  41582
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41582
tgggtgggag cagccgcggg                                                   20


<210>  41583
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41583
cagcattctt gggtgggagc                                                   20


<210>  41584
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41584
tgggtgggag cagccacggg                                                   20


<210>  41585
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41585
tggctgtggc ccttgtggct                                                   20


<210>  41586
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41586
gtgccattca tggctgtggc                                                   20


<210>  41587
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41587
acgtgccctt ctccaatgcg                                                   20


<210>  41588
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41588
ccaatgcgac gggtgtggta                                                   20


<210>  41589
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41589
agtacccaca gtactacctg                                                   20


<210>  41590
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41590
ccatgctggc cgcctacatg                                                   20


<210>  41591
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41591
gctgatcgtg ctgggcttcc                                                   20


<210>  41592
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41592
ccatcaactt cctcacgctc                                                   20


<210>  41593
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41593
tcacgctcta cgtcaccgtc                                                   20


<210>  41594
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41594
tgtgctggac ggtgacgtag                                                   20


<210>  41595
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41595
tggtcctagg tggcttcacc                                                   20


<210>  41596
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41596
ccagcaccct ctacacctct                                                   20


<210>  41597
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41597
tcttcgggcc cacaggatgc                                                   20


<210>  41598
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41598
ggcccacagg atgcaatttg                                                   20


<210>  41599
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41599
ttgccaccct gggcggtatg                                                   20


<210>  41600
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41600
aaggggctcc gcaccacgcc                                                   20


<210>  41601
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41601
aagtggctcc gcaccacgcc                                                   20


<210>  41602
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41602
tggctgtggc ccttgtggct                                                   20


<210>  41603
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41603
tgggtgggag cagccacggg                                                   20


<210>  41604
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41604
aagtggctcc gcaccacg                                                     18


<210>  41605
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41605
aagtggctcc gcaccacgc                                                    19


<210>  41606
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41606
aaggggctcc gcaccacg                                                     18


<210>  41607
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41607
aaggggctcc gcaccacgc                                                    19


<210>  41608
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41608
aaggggctgc gtaccaca                                                     18


<210>  41609
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41609
aaggggctgc gtaccacac                                                    19


<210>  41610
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41610
aagtggctgc gtaccaca                                                     18


<210>  41611
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho spacer

<400>  41611
aagtggctgc gtaccacac                                                    19


<210>  41612
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41612
ggatatctgt gggacaagag                                                   20


<210>  41613
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41613
ccgattttga ttctcaaaca                                                   20


<210>  41614
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41614
caaacaaatg tgtcacaaag                                                   20


<210>  41615
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41615
gatgtgtata tcacagacaa                                                   20


<210>  41616
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41616
ggaataatgc tgttgttgaa                                                   20


<210>  41617
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41617
tgtcccacag atatccagaa                                                   20


<210>  41618
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41618
gctggtacac ggcagggtca                                                   20


<210>  41619
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41619
cagctggtac acggcagggt                                                   20


<210>  41620
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41620
aaatccagtg acaagtctgt                                                   20


<210>  41621
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41621
aggccacagc actgttgctc                                                   20


<210>  41622
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41622
cagggttctg gatatctgt                                                    19


<210>  41623
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41623
agagtctctc agctggtaca                                                   20


<210>  41624
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41624
tgtgctagac atgaggtcta                                                   20


<210>  41625
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41625
taggcagaca gacttgtcac                                                   20


<210>  41626
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41626
atttgtttga gaatcaaaat                                                   20


<210>  41627
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41627
acacggcagg gtcagggttc                                                   20


<210>  41628
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41628
agagcaacag tgctgtggcc                                                   20


<210>  41629
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41629
aaagtcagat ttgttgctcc                                                   20


<210>  41630
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41630
tggaataatg ctgttgttga                                                   20


<210>  41631
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41631
gacaccttct tccccagccc                                                   20


<210>  41632
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41632
agaagacacc ttcttcccca                                                   20


<210>  41633
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41633
tccccagccc aggtaagggc                                                   20


<210>  41634
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41634
ccagcccagg taagggcagc                                                   20


<210>  41635
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41635
tggtacacgg cagggtcagg gtt                                               23


<210>  41636
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41636
tctcagctgg tacacggcag ggt                                               23


<210>  41637
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41637
agagtctctc agctggtaca cgg                                               23


<210>  41638
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41638
tgaataggca gacagacttg tca                                               23


<210>  41639
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41639
cttactttgt gacacatttg ttt                                               23


<210>  41640
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41640
ctcaaacaaa tgtgtcacaa agt                                               23


<210>  41641
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41641
agttttgtct gtgatataca cat                                               23


<210>  41642
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41642
gggctgggga agaaggtgtc ttc                                               23


<210>  41643
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41643
tgtcccacag atatccagaa                                                   20


<210>  41644
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41644
gctggtacac ggcagggtca                                                   20


<210>  41645
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41645
acaacagcat tattccagaa                                                   20


<210>  41646
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41646
gcaccaaagc tgcccttacc                                                   20


<210>  41647
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41647
ttttagaaag ttcctgtgat                                                   20


<210>  41648
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41648
tgtgatgtca agctggtcga                                                   20


<210>  41649
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41649
cgaccagctt gacatcacag                                                   20


<210>  41650
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41650
aagcttttct cgaccagctt                                                   20


<210>  41651
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41651
aaacctgtca gtgattgggt                                                   20


<210>  41652
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41652
gaacccaatc actgacaggt                                                   20


<210>  41653
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC spacer

<400>  41653
ggaggaggat tcggaaccca                                                   20


<210>  41654
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41654
gacaacagtt tgccgctgcc                                                   20


<210>  41655
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41655
gcaatcctca aaaacagatg                                                   20


<210>  41656
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41656
caatttttcc tgtagaatac                                                   20


<210>  41657
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41657
gtctgacagc tgtttgcaga                                                   20


<210>  41658
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41658
ggcttcccaa tttttcctgt                                                   20


<210>  41659
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41659
ttagaagaat atttcatgag                                                   20


<210>  41660
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41660
tgcatttgca gagtttagtt                                                   20


<210>  41661
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41661
tttttggtat cttacaggaa ctc                                               23


<210>  41662
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41662
tttgccgctg cccaatgcca tcc                                               23


<210>  41663
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41663
agcggcaaac tgttgtcaga aca                                               23


<210>  41664
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41664
ttctacagga aaaattggga agc                                               23


<210>  41665
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41665
ttcaggcttc ccaatttttc ctg                                               23


<210>  41666
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41666
tggtatctta caggaactcc                                                   20


<210>  41667
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41667
gccgctgccc aatgccatcc                                                   20


<210>  41668
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41668
caatttttcc tgtagaatac                                                   20


<210>  41669
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41669
cctcctgcca ccgcagattc                                                   20


<210>  41670
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41670
agctgtcaga cagaaaaaag                                                   20


<210>  41671
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41671
tgatccatat gcttttacct                                                   20


<210>  41672
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41672
tattagatct gtcgccctac                                                   20


<210>  41673
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41673
atgttctgac aacagtttgc                                                   20


<210>  41674
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41674
ccagttgcat tcaatgttct                                                   20


<210>  41675
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41675
tccccagttg cattcaatgt                                                   20


<210>  41676
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41676
ctggcatctg tttttgagga ttg                                               23


<210>  41677
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41677
gtagaatact ggcatctgtt ttt                                               23


<210>  41678
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41678
agaggtaggg cgacagatct aat                                               23


<210>  41679
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41679
atcttacagg aactccagga                                                   20


<210>  41680
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41680
caggaactcc aggatggcat                                                   20


<210>  41681
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41681
tccaggatgg cattgggcag                                                   20


<210>  41682
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41682
ttttattcta gttgaaagaa                                                   20


<210>  41683
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41683
gaattctttc aactagaata                                                   20


<210>  41684
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41684
ttcaactaga ataaaaggaa                                                   20


<210>  41685
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41685
actagaataa aaggaaaaat                                                   20


<210>  41686
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41686
gagtaggagc taaaatattt                                                   20


<210>  41687
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41687
tttttgcaaa aacccaaaat                                                   20


<210>  41688
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41688
tttttccttt ttgcaaaaac                                                   20


<210>  41689
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41689
ttccttcatt taggaagcat                                                   20


<210>  41690
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41690
ttccagttac tctacatctt                                                   20


<210>  41691
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41691
aacacgaatt aggcactccg                                                   20


<210>  41692
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41692
cctctggtgt ccccaggcag                                                   20


<210>  41693
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41693
aattatctgc aaagatttta                                                   20


<210>  41694
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41694
tagcaaactt tacgcacaga                                                   20


<210>  41695
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41695
tattgacttt attagtcaaa                                                   20


<210>  41696
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41696
tgataagtaa aattacaaca                                                   20


<210>  41697
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41697
aagctacctc acatactaat                                                   20


<210>  41698
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41698
gtaaggacaa agtcaattaa                                                   20


<210>  41699
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41699
tatcatgggc caggcgtggt                                                   20


<210>  41700
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41700
gattagggta agttgaggag                                                   20


<210>  41701
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41701
atctgcaata gccaattgcc                                                   20


<210>  41702
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41702
tgtcctttgt agggacatgg                                                   20


<210>  41703
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41703
ggatccaatc cagaatctcc                                                   20


<210>  41704
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41704
tggagttttc agcaagtaag                                                   20


<210>  41705
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41705
aatttatatt ggaaatcttg                                                   20


<210>  41706
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41706
cgagccttgg ttttcagctc                                                   20


<210>  41707
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41707
ttgcagcctg ccctgcattc                                                   20


<210>  41708
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41708
caagtacatt ttaaagatag                                                   20


<210>  41709
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41709
agttgaaaga attcagaatc                                                   20


<210>  41710
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41710
ccagagtaac agtctgagta                                                   20


<210>  41711
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41711
tggagttcct gtaagatacc                                                   20


<210>  41712
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41712
tttttgtttt gcctttttgg                                                   20


<210>  41713
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41713
tacaggaact ccaggatggc                                                   20


<210>  41714
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41714
aaaacactag ctgccagtca                                                   20


<210>  41715
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41715
ttcaaaaaca ctagctgcca                                                   20


<210>  41716
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41716
ttctttcaaa aacactagct                                                   20


<210>  41717
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41717
tctttctttc aaaaacacta                                                   20


<210>  41718
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41718
gactggcagc tagtgttttt                                                   20


<210>  41719
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41719
tcaaacagaa ggtatggata                                                   20


<210>  41720
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41720
aacagaaggt atggataaaa                                                   20


<210>  41721
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41721
ataccttctg tttgatgatc                                                   20


<210>  41722
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41722
ttgatactaa ccttggtttc                                                   20


<210>  41723
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41723
cagaaaccaa ggttagtatc                                                   20


<210>  41724
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41724
gacagaaaaa agaggtaggg                                                   20


<210>  41725
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41725
gtcgccctac ctcttttttc                                                   20


<210>  41726
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41726
ttttttctca taccttctgc                                                   20


<210>  41727
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41727
tcaagcagaa ggtatgagaa                                                   20


<210>  41728
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41728
cataccttct gcttgatgat                                                   20


<210>  41729
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41729
agcagaaggt atgagaaaaa                                                   20


<210>  41730
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41730
atatgctttt acctgcaggc                                                   20


<210>  41731
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41731
acagatctgt caaatcgcct                                                   20


<210>  41732
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41732
gtcaaatcgc ctgcaggtaa                                                   20


<210>  41733
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41733
taaggtaagt ctttgatttg                                                   20


<210>  41734
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41734
aagacttacc ttaagatacc                                                   20


<210>  41735
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41735
caacagatct gtcaaatcgc                                                   20


<210>  41736
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMD spacer

<400>  41736
aatcgcctgc aggtaaaagc                                                   20


<210>  41737
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BCL11A spacer

<400>  41737
tggagcctgt gataaaagca                                                   20


<210>  41738
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BCL11A spacer

<400>  41738
ctaacagttg cttttatcac                                                   20


<210>  41739
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C9Orf72 spacer

<400>  41739
cgtaacctac ggtgtcccgc                                                   20


<210>  41740
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C9Orf72 spacer

<400>  41740
gtaacctacg gtgtcccgct                                                   20


<210>  41741
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41741
tgctattccg gcgcctccac                                                   20


<210>  41742
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41742
ccccctcccc cgactacaca                                                   20


<210>  41743
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41743
tcaaggccga aggcggaaac                                                   20


<210>  41744
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41744
gccttcggcc ttgaggaata                                                   20


<210>  41745
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41745
gccttgagga ataaccgcct                                                   20


<210>  41746
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41746
ctgggtcccg cccccgggcg                                                   20


<210>  41747
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41747
ggccagtggg aggtgctggc                                                   20


<210>  41748
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41748
cgccgcctga ctcgccacgt                                                   20


<210>  41749
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41749
ggcgcctcca ctccgtcccc                                                   20


<210>  41750
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41750
ctacttgtgt cactaacgga                                                   20


<210>  41751
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41751
gcatcaggag gttggtgacc                                                   20


<210>  41752
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41752
ccttcagcat caggaggttg                                                   20


<210>  41753
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41753
ccatggtgtt ggcagcctcc                                                   20


<210>  41754
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41754
tcgagatgaa cacggaggag                                                   20


<210>  41755
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41755
gctccttgtg gttggagaac                                                   20


<210>  41756
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41756
ccaaccacaa ggagctgaag                                                   20


<210>  41757
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41757
tggtgaaggt gatgatcttc                                                   20


<210>  41758
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41758
ccaagaacaa ccagttccag                                                   20


<210>  41759
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41759
aagctcacca gcctcaacgt                                                   20


<210>  41760
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41760
ctcccacctt tgccattcct                                                   20


<210>  41761
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41761
tgcccccgcc aggcccggga                                                   20


<210>  41762
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41762
gtattgctgg tcagcaacct                                                   20


<210>  41763
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41763
tattgaacag gatcttcacg                                                   20


<210>  41764
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41764
ccttcttatt gaacaggatc                                                   20


<210>  41765
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41765
tgaagcggtg caggggtgag                                                   20


<210>  41766
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41766
tggagcccgg cttcttgaag                                                   20


<210>  41767
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41767
ggaagttctt ggagcccggc                                                   20


<210>  41768
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41768
agaagccggg ctccaagaac                                                   20


<210>  41769
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41769
ccaagtccac catctagggg                                                   20


<210>  41770
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41770
ctttaaaaaa ataaaatctc                                                   20


<210>  41771
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41771
agttgaccaa atattctaat                                                   20


<210>  41772
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41772
ttgtggtatt accttgtatg                                                   20


<210>  41773
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41773
ttgtaattaa gtcacaggca                                                   20


<210>  41774
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41774
agagagcagg cggggccgcc                                                   20


<210>  41775
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41775
aattttggac caaagtctca                                                   20


<210>  41776
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTBP1 spacer

<400>  41776
ctgtggacgc tgtagaggca                                                   20


<210>  41777
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG-free 5' ITR

<400>  41777
tgctcactca ctcactcact gaggcctgca gagcaaagct ctgcagtctg gggacctttg       60

gtccccaggc ctcagtgagt gagtgagtga gcagagaggg agtggccaac tccatcacta      120

ggggttcct                                                              129


<210>  41778
<211>  252
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  41778
aatggaggcg gtactatgta gatgagaatt caggagcaaa ctgggaaaag caactgcttc       60

caaatatttg tgatttttac agtgtagttt tggaaaaact cttagcctac caattcttct      120

aagtgtttta aaatgtggga gccagtacac atgaagttat agagtgtttt aatgaggctt      180

aaatatttac cgtaactatg aaatgctacg catatcatgc tgttcaggct ccgtggccac      240

gcaactcata ct                                                          252


<210>  41779
<211>  252
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  41779
aatggaggcg gtactatgta gatgagaatt caggagcaaa ctgggaaaag caactgcttc       60

caaatatttg tgatttttac agtgtagttt tggaaaaact cttagcctac caattcttct      120

aagtgtttta aaatgtggga gccagtacac atgaagttat agagtgtttt aatgaggctt      180

aaatatttac cgtaactatg aaatgctaca catatcatgc tgttcaggct ctgtggccat      240

gcaactcata ct                                                          252


<210>  41780
<211>  252
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  41780
aatggaggtg gtactatgta gatgagaatt caggagcaaa ctgggaaaag caactgcttc       60

caaatatttg tgatttttac agtgtagttt tggaaaaact cttagcctac caattcttct      120

aagtgtttta aaatgtggga gccagtacac atgaagttat agagtgtttt aatgaggctt      180

aaatatttac tgtaactatg aaatgctaca catatcatgc tgttcaggct ctgtggccat      240

gcaactcata ct                                                          252


<210>  41781
<211>  241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  41781
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatat ttgatgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttctat ttcttggctt tatatatctt gtggaaagga      240

c                                                                      241


<210>  41782
<211>  241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  41782
gagggcctat ttcccatgat tccttcatat ttgcatatac aatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatat ttgatgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttacca taacttgaaa gtatttctat ttcttggctt tatatatctt gtggaaagga      240

c                                                                      241


<210>  41783
<211>  400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  41783
accaagtgac gatcacagct atccacaaac aagaactgcg acccaaatcc cggctgcgac       60

ggaactagct gtgccacacc cggcgcgtcc ttatataatc atcggcgttc accgccccaa      120

ggagatccct ccgcagaatc gccgagaagg gactactttt cctcgcctgt tccgctctct      180

ggaaagaaaa ccagtgccct agagtcaccc aagtcccgtc ctaaaatgtc cttctgctga      240

tactggggtt ctaaggctga gtcttatgag cagcgggctg ctgtcctgag cgtccaggcg      300

gaaggatcag gaggctcgct gcgcccttcg tctgacgtgg cagcgctcgc cgtgaggagg      360

ggggcgcccg cgggaggcgc caaaacccgg tgcggaggcc                            400


<210>  41784
<211>  400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  41784
accaagtgat gatcacagct atccacaaac aagaactgag acccaaatcc cagctgccac       60

ggaactagct gtgccacacc cggtgtctcc ttatataatc ataggaattc accgccccaa      120

ggagatccct ccgcagaatt gccgagaagg gactactttt cctagcctgt tccactctct      180

ggaaagaaaa ccagtgccct agagtcaccc aagtcccttc ctaaaatgtc cttctgctga      240

tactggggtt ctaaggctga gtcttatgag cagagggctg ctgtcctgag ggtccaggcg      300

gaaggatcag gaggctcact gagcccttcg tctgacgtgg cagatctggc cgtgaggagg      360

ggggaacccg cgggaggcac caaaacccgg tggggaggcc                            400


<210>  41785
<211>  400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  41785
accaagtgat gatcacagct atccacaaac aagaactgag acccaaatcc cagctgccat       60

ggaactagct gtgccacacc tggtgtctcc ttatataatc ataggaattc actgccccaa      120

ggagatccct ctgcagaatt gctgagaagg gactactttt cctagcctgt tccactctct      180

ggaaagaaaa ccagtgccct agagtcaccc aagtcccttc ctaaaatgtc cttctgctga      240

tactggggtt ctaaggctga gtcttatgag cagagggctg ctgtcctgag ggtccaggtg      300

gaaggatcag gaggctcact gagccctttg tctgatgtgg cagatctggc tgtgaggagg      360

ggggaacctg tgggaggcac caaaacctgg tggggaggcc                            400


<210>  41786
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  41786
ggatcctact gacgaggggc ttgtccaaac aagcccgggc atgcctaaac atgccctgat       60

gcaatcctga cgtcgtgaag caatgattat gcaatttgag catgtccaga ctagccctga      120

cggatgacgc ttgacgcaat tcctgaggca agtctgagct tgttcaaact tgtcttgaag      180

aaattatgac ggactgacgt atggtgcaat attggggcaa tgcttgacgt tcgcggtagg      240

cgtgtacggt gggaggtcta tataagcaga gctcgtttag tgaaccgtca gatcgcctgg      300

agacgccatc cacgctgttt tgacctccat agaagtcacc gggaccgatc cagc            354


<210>  41787
<211>  197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  41787
tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc ccgcccctaa       60

ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt atttatgcag      120

aggccgaggc cgcctcggcc tctgagctat tccagaagta gtgaggaggc ttttttggag      180

gcctaggctt ttgcaaa                                                     197


<210>  41788
<211>  178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  41788
ctgacaaatt cagtataaaa gcttggggct ggggccgagc actggggact ttgagggtgg       60

ccaggccagc gtaggaggcc agcgtaggat cctgctggga gcggggaact gagggaagcg      120

acgccgagaa agcaggcgta ccacggaggg agagaaaagc tccggaagcc cagcagcg        178


<210>  41789
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  41789
ggggggctat aaaagggggt gggggcgttc gtcctcactc t                           41


<210>  41790
<211>  212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  41790
gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgat       60

ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc      120

gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc      180

tttttcgcaa cgggtttgcc gccagaacac ag                                    212


<210>  41791
<211>  223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter variant sequence

<400>  41791
acagcgctga ccgcggaggt ccaaccggaa gaatgtccgg attggacatt cggaagaggg       60

cccgccttcc ctggggaatc tctgcgcacg cgcagaacgc ttcgaccaat gaaaacacag      120

gaagccgtcc gcgcaaccgc gttgcgtcac ttctgccgcc cctgtttcaa gggataagaa      180

accctgcgac aaaacctcct ccttttccaa gcggctgccg aag                        223


<210>  41792
<211>  3006
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  41792
atggctccag ctgccaagag agtgaagctg gactctagac aagagatcaa gaggatcaac       60

aagattagaa gaaggctggt caaggacagc aacaccaaga aggcaggcaa gacaggcccc      120

atgaagaccc tgcttgtcag agtgatgacc cctgacctga gagagagact ggaaaacctg      180

agaaagaagc ctgagaacat ccctcagcct atctccaaca ccagcagagc caacctgaac      240

aagctgctga cagactacac agagatgaag aaagccatcc tgcatgtgta ctgggaagag      300

ttccagaaag accctgtggg cctgatgagc agagtggccc agcctgccag caagaagatt      360

gaccagaaca aactgaagcc agagatggat gagaagggca acctgaccac agctggcttt      420

gcctgctctc agtgtggcca gcctctgttt gtgtacaagc tggaacaagt gtctgagaaa      480

ggcaaggcct acaccaacta ctttggcaga tgcaatgtgg ctgagcatga gaagctgatc      540

ctgctggccc agctgaagcc tgaaaaggac tctgatgagg ctgtgaccta cagcctgggc      600

aagtttggac agagagccct ggacttctac agcatccatg tgaccaaaga aagcacacac      660

cctgtgaagc ccctggctca gattgctggc aacagatatg cctctggacc tgtgggcaaa      720

gccctgtctg atgcctgcat gggaaccatt gccagctttc tgagcaagta ccaggacatc      780

atcattgagc accagaaagt ggtcaagggg aaccagaaga ggctggaatc tctgagagag      840

ctggctggca aagagaacct ggaatacccc tctgtgaccc tgcctcctca gcctcacacc      900

aaagagggtg ttgatgccta caatgaagtg attgccagag tcaggatgtg ggtcaacctg      960

aatctgtggc agaagctgaa gctgagcagg gatgatgcca agcctctgct gagactgaag     1020

ggcttcccta gcttcccact ggtggaaagg caggctaatg aagtggattg gtgggacatg     1080

gtctgcaatg tgaagaaact gatcaatgag aagaaagagg atggcaaggt tttctggcag     1140

aacctggctg gctacaagag gcaagaagcc ctgaggcctt acctgtcctc tgaggaagat     1200

aggaagaagg ggaagaagtt tgccagatac cagctgggag atctgctgct gcacctggaa     1260

aagaaacatg gggaagattg gggcaaagtg tatgatgagg cctgggagag aattgacaag     1320

aaggtggaag gcctgagcaa gcacattaag ctggaagagg aaagaagatc tgaggatgcc     1380

cagagcaagg ctgccctgac tgattggctg agagccaagg ccagctttgt gattgagggc     1440

ctgaaagagg ctgacaagga tgagttctgt agatgtgaac tgaagctgca aaagtggtat     1500

ggggacctga ggggcaagcc ctttgccatt gaggcagaga acagcatcct ggacatcagt     1560

ggcttcagca agcagtacaa ctgtgccttc atttggcaga aggatggggt taagaagctc     1620

aacctgtacc tgatcatcaa ctacttcaaa ggtggcaagc tgaggttcaa gaagatcaag     1680

ccagaggcct ttgaggccaa caggttctac acagtgatca acaaaaagtc tggggagatt     1740

gtgcccatgg aagtgaactt caactttgat gatcccaacc tcatcatcct gccactggcc     1800

tttggcaaga gacagggcag agaattcatc tggaatgacc tgctgagcct ggaaacaggc     1860

agcctgaaac tggccaatgg cagagtgatt gagaaaaccc tgtacaacag aaggaccaga     1920

caggatgagc ctgcactgtt tgtggccctg acctttgaga gaagggaagt gctggatagc     1980

agcaacatca agcccatgaa cctgattgga gtggacagag gggagaatat ccctgctgtc     2040

attgccctga cagaccctga gggctgtccc ctgagcagat tcaaggactc cctgggcaac     2100

cccacacaca ttctgagaat tggggagagc tacaaagaga agcagagaac catccaggcc     2160

aagaaagaag tggaacagag gagagctgga ggctactcta ggaagtatgc cagcaaagcc     2220

aagaatctgg ctgatgacat ggtcagaaac acagccaggg acctgctgta ctatgctgtg     2280

acccaggatg ccatgctgat ctttgagaat ctgagcagag gatttgggag acaaggcaag     2340

aggaccttca tggctgaaag acagtacacc aggatggaag attggctgac tgccaaactg     2400

gcctatgagg gactgagcaa gacctacctg tccaagacac tggcccagta tacctccaag     2460

acctgcagca attgtggctt caccatcacc tctgcagact atgacagagt gctggaaaag     2520

ctcaagaaaa cagccacagg ctggatgacc accatcaatg ggaaagagct gaaggttgag     2580

ggccagatca cctactacaa cagatacaaa aggcagaatg tggttaagga cctgtctgtg     2640

gaactggaca gactgtctga ggaatctgtg aacaatgaca tcagcagctg gaccaagggc     2700

agatctgggg aagctctgag cctgctgaag aagagattca gccacagacc tgtgcaagag     2760

aagtttgtgt gtctgaactg tggctttgag acacatgctg atgaacaggc tgctctgaac     2820

attgccagaa gctggctgtt cctgagaagc caagagtaca agaagtacca gaccaacaag     2880

accacaggca acactgacaa gagggccttt gtggaaacct ggcagagctt ctacagaaag     2940

aaactcaaag aagtctggaa gcctgctgtg ggcagccctg cagctaaaag ggtcaagctg     3000

gactga                                                                3006


<210>  41793
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41793
atatttgcat gtcgctatgt gttctgggaa atcaccataa acgtgaaatg tctttggatt       60

tgggaatctt ataagttctg tatgagacca c                                      91


<210>  41794
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41794
atatttagca tgtcgctatg tgttctggga aatcaccata aacgtgaaat gtctttggat       60

ttgggaatct tataagttct gtatgagacc ac                                     92


<210>  41795
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41795
atatttgcat gtctgcaagg cattctggat agtcaccata aacgtgaaat gtctttggat       60

ttgggaatct tataagttct gtatgagacc ac                                     92


<210>  41796
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41796
atatttgcat gtcgctatgt gttctgggaa attgacctaa gtgtaaagtg tctttggatt       60

tgggaatctt ataagttctg tatgagacca c                                      91


<210>  41797
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41797
atatttagca ttctgcaagg cattctggat agtgacctaa gtgtaaagtg tctttggatt       60

tgggaatctt atatattctg tatgagacca c                                      91


<210>  41798
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41798
atatttagca ttctgcaagg cattctggat agtcaccata aacgtgaaat gtctttggat       60

ttgggaatct tataagttct gtatgagacc ac                                     92


<210>  41799
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41799
atatttgcat gtcgctatgt gttctgggaa acttgaccta agtgtaaagt tgagatttcc       60

ttcaggtttt ataagttctg tatgagacca c                                      91


<210>  41800
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41800
atatttgcat gtcgctatgt gttctgggaa atcaccataa acgtgaaatt tgagatttcc       60

ttcaggtttt ataagttctg tatgagacca c                                      91


<210>  41801
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41801
atatttgcat gtcgctatgt gttctgggaa acttgaccta agtgtaaagt tgagatttcc       60

ttcaggttta tatagttctg tatgagacca c                                      91


<210>  41802
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41802
atatttagca tgtcgctatg tgttctggga aacttgacct aagtgtaaag ttgagatttc       60

cttcaggttt atatagttct gtatgagacc ac                                     92


<210>  41803
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41803
atatttgcat gatttcccat gattccttca ttcaccataa acgtgaaatg tctttggatt       60

tgggaatctt ataagttctg tatgagacca c                                      91


<210>  41804
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41804
atatttgcat gtcgctatgt gttctgggaa atcttaccgt aacttgaaag tagtctttgg       60

atttgggaat cttataagtt ctgtatgaga ccac                                   94


<210>  41805
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41805
atatttgcat atttcccatg attccttcat cttaccgtaa cttgaaagta gtctttggat       60

ttgggaatct tatatattct gtatgagacc ac                                     92


<210>  41806
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41806
atatttgcat atttcccatg attccttcat tcaccataaa cgtgaaatgt ctttggattt       60

gggaatctta taagttctgt atgagaccac                                        90


<210>  41807
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41807
atatttgcat gtcgctatgt gttctgggaa actcttaccg taacttgaaa gtatgagatt       60

tccttcaggt tttataagtt ctgtatgaga ccac                                   94


<210>  41808
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41808
atatttgcat gtcgctatgt gttctgggaa actcttaccg taacttgaaa gtatgagatt       60

tccttcaggt ttatatagtt ctgtatgaga ccac                                   94


<210>  41809
<211>  249
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41809
gccacctctt ttgcatattg gcacccacaa tccaccgcgg ctatgaggcc agtataaggc       60

ggtaaaatta cgataagata tgggatttta cgtgatcgaa gacatcaaag taagcgtaag      120

cacgaaagtt gttctgcaac ataccactgt aggaaattat gctaaatatg aaaccgacca      180

taagttatcc taaccaaaag atgatttgat tgaagggctt aaaataggtg tgacagtaac      240

ccttgagtc                                                              249


<210>  41810
<211>  249
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41810
tcccttaccc agggtgcccc gggcgctcat ttgcatgtcc cacccaacag gtaaacctga       60

cagatcggtc gcggccaggt acggcctggc ggtcagagca ccaaacttac gagccttgtg      120

atgagttccg ttacatgaaa ttctcctaaa ggctccaaga tggacaggaa agcgctcgat      180

tcggttaccg taaggaaaac aaatgagaaa ctcccgtgcc ttataagacc tggggacgga      240

cttatttgc                                                              249


<210>  41811
<211>  249
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41811
cccttaccca gggtgccccg ggcgctcatt tgcatgtccc acccaacagg taaacctgac       60

aggtcatcgc ggccaggtac gacctggcgg tcagagcacc aaacatacga gccttgtgat      120

gagttccgtt gcatgaaatt ctcccaaagg ctccaagatg gacaggaaag ggcgcggttc      180

ggtcaccgta agtagaatag gtgaaagact cccgtgcctt ataaggcctg tgggtgactt      240

cttctcaac                                                              249


<210>  41812
<211>  249
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41812
caggctctgc cccgcctccg gggctatttg catacgacca tttccagtaa ttcccagcag       60

ccaccgtagc tatatttggt agaacaacga gcactttctc aactccagtc aataactacg      120

ttagttgcat tacacattgg gctaatataa atagaggtta aatctctagg tcatttaaga      180

gaagtcggcc tatgtgtaca gacatttgtt ccaggggctt taaatagctg gtggtggaac      240

tcaatattc                                                              249


<210>  41813
<211>  241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41813
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatat ttgatgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttctat ttcttggctt tatatatctt gtggaaagga      240

c                                                                      241


<210>  41814
<211>  241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pol III promoter

<400>  41814
gagggcctat ttcccatgat tccttcatat ttgcatatac aatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatat ttgatgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttacca taacttgaaa gtatttctat ttcttggctt tatatatctt gtggaaagga      240

c                                                                      241


<210>  41815
<211>  131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG-free 3' ITR

<400>  41815
tctgctcact cactcactca ctgaggcctg cagagcaaag ctctgcagtc tggggacctt       60

tggtccccag gcctcagtga gtgagtgagt gagcagagag ggagtggcca actccatcac      120

taggggttcc t                                                           131


<210>  41816
<211>  208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly A signal

<400>  41816
ctgtgccttc tagttgccag ccatctgttg tttgcccctc cccagtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcacattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagagaa tagcaggcat gctgggga                                         208


<210>  41817
<211>  141
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasX scaffold variant

<400>  41817
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcugcacu augggcgcag cgucaaugac gcugacggua caggccagac aauuauuguc      120

ugguauagug cagcaucaaa g                                                141


<210>  41818
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NTSB domain

<400>  41818

Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met 
1               5                   10                  15      


Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys 
            20                  25                  30          


Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly 
        35                  40                  45              


Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu 
    50                  55                  60                  


Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu 
65                  70                  75                  80  


Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
                85                  90      


<210>  41819
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  helical I-II domain

<400>  41819

Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
1               5                   10                  15      


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
            20                  25                  30          


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
        35                  40                  45              


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
    50                  55                  60                  


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
65                  70                  75                  80  


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
                85                  90                  95      


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
            100                 105                 110         


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
        115                 120                 125             


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe 
    130                 135                 140     


<210>  41820
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  helical II domain

<400>  41820

Pro Leu Val Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val 
1               5                   10                  15      


Cys Asn Val Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val 
            20                  25                  30          


Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro 
        35                  40                  45              


Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg 
    50                  55                  60                  


Tyr Gln Leu Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu 
65                  70                  75                  80  


Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys 
                85                  90                  95      


Val Glu Gly Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser 
            100                 105                 110         


Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys 
        115                 120                 125             


Ala Ser Phe Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe 
    130                 135                 140                 


Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly 
145                 150                 155                 160 


Lys Pro Phe Ala Ile Glu Ala Glu 
                165             


<210>  41821
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RuvC-I domain

<400>  41821

Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly Glu 
1               5                   10                  15      


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
            20                  25                  30          


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
        35                  40                  45              


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
    50                  55                  60                  


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
65                  70                  75                  80  


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
                85                  90                  95      


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
            100                 105                 110         


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
        115                 120                 125             


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
    130                 135                 140                 


Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
145                 150                 155                 160 


Ser Lys Thr Cys 
                


<210>  41822
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OBD-I domain

<400>  41822

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln 
    50                  55      


<210>  41823
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OBD-II domain

<400>  41823

Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala 
1               5                   10                  15      


Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile 
            20                  25                  30          


Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro 
        35                  40                  45              


Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser 
    50                  55                  60                  


Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn 
65                  70                  75                  80  


Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe 
                85                  90                  95      


Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala 
            100                 105                 110         


Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln 
        115                 120                 125             


Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val 
    130                 135                 140                 


Leu Asp 
145     


<210>  41824
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  helical I-I domain

<400>  41824

Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu Leu Thr Asp 
1               5                   10                  15      


Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp Glu Glu Phe 
            20                  25                  30          


Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala 
        35                  40                  


<210>  41825
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSL domain

<400>  41825

Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu 
1               5                   10                  15      


Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly 
            20                  25                  30          


Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys 
        35                  40                  45              


Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser 
    50                  55                  60                  


Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser 
65                  70                  75                  80  


Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val 
                85                  90                  95      


Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His 
            100                 105                 110 


<210>  41826
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RuvC-II domain

<400>  41826

Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu 
1               5                   10                  15      


Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn 
            20                  25                  30          


Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys 
        35                  40                  45              


Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
    50                  55              


<210>  41827
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  41827

Ser Arg Arg Arg Lys Ala Asn Pro Thr Lys Leu Ser Glu Asn Ala Lys 
1               5                   10                  15      


Lys Leu Ala Lys Glu Val Glu Asn 
            20                  


<210>  41828
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization signal

<400>  41828

Lys Arg Thr Ala Asp Ser Gln His Ser Thr Pro Pro Lys Thr Lys Arg 
1               5                   10                  15      


Lys Val Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
            20                  25              


<210>  41829
<211>  46
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  triplex


<220>
<221>  misc_feature
<222>  (37)..(39)
<223>  n is a, c, g, or u

<400>  41829
acuggcgcuu uuaucugauu acuuugagag ccaucannna ucaaag                      46


<210>  41830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  41830
uucucggcgc ugcaccacgu                                                   20


<210>  41831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  41831
caagaggaga agcaguuugg                                                   20


<210>  41832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  41832
ggggccugug ccaucucucg                                                   20


<210>  41833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  41833
aggggucuuc gagaagaccc                                                   20


<210>  41834
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  triplex loop sequence

<400>  41834
cuuuaucuca uuacuuuga                                                    19


<210>  41835
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pseudoknot sequence with triplex loop sequence

<400>  41835
aaaacgcuuu aucucauuac uuugacgttt t                                      31


<210>  41836
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  constraint string


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  n is a, c, g, or u

<400>  41836
nnnnnnnnnn nnnnnnnnn                                                    19


<210>  41837
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  41837
agagcgtgat attaccctgt                                                   20


<210>  41838
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  41838
ccctttgacg ttggagtcca                                                   20


<210>  41839
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  41839
tccccgatat gcaccaccgg                                                   20


<210>  41840
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  41840
aagtggctgc gtaccacacc                                                   20


<210>  41841
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  41841
gtacatccac aaacagacga                                                   20


<210>  41842
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  41842
ccgatatgca ccaccgggta                                                   20


<210>  41843
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Stem IIB loop

<400>  41843
ugggcgcagc gucaaugacg cugacgguac a                                      31


<210>  41844
<211>  66
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Stem II loop

<400>  41844
gcacuauggg cgcagcguca augacgcuga cgguacaggc cagacaauua uugucuggua       60

uagugc                                                                  66


<210>  41845
<211>  167
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Stem II-V loop

<400>  41845
caggaagcac uaugggcgca gcgucaauga cgcugacggu acaggccaga caauuauugu       60

cugguauagu gcagcagcag aacaauuugc ugagggcuau ugaggcgcaa cagcaucugu      120

ugcaacucac agucuggggc aucaagcagc uccaggcaag aauccug                    167


<210>  41846
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RBE loop

<400>  41846
gcugacggua caggc                                                        15


<210>  41847
<211>  234
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Full-length RRE loop

<400>  41847
aggagcuuug uuccuugggu ucuugggagc agcaggaagc acuaugggcg cagcgucaau       60

gacgcugacg guacaggcca gacaauuauu gucugguaua gugcagcagc agaacaauuu      120

gcugagggcu auugaggcgc aacagcaucu guugcaacuc acagucuggg gcaucaagca      180

gcuccaggca agaauccugg cuguggaaag auaccuaaag gaucaacagc uccu            234


